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<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B4UMZ7</accession>
    <name>B4UMZ7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0F03261g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWI5/SAE3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAR58021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UMZ7"/>
    <dbReference type="FunCoup" id="B4UMZ7">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UMZ7"/>
    <dbReference type="KEGG" id="cgr:9487987"/>
    <dbReference type="CGD" id="CAL0131156">
        <property type="gene designation" value="CAGL0F03261g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03261g"/>
    <dbReference type="eggNOG" id="ENOG502S9IK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106110_2_0_1"/>
    <dbReference type="InParanoid" id="B4UMZ7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034974">
        <property type="term" value="C:Swi5-Swi2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010772">
        <property type="term" value="P:meiotic DNA recombinase assembly involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010760">
        <property type="entry name" value="DNA-repair_Swi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28529:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN SWI5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07061">
        <property type="entry name" value="Swi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAR58021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="101" mass="11684" checksum="19DC154BAD6A948F" modified="2008-09-23" version="1">MMTDIEGQIRELKAHLVELQLQRKYLDEKFIQLFKSAYQNSVDKEPDMESPVKIIAKHIKSLKTYNELRDVGLKLAQCVADEKNVSIGQIFEEIGISMKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN33</accession>
    <name>B4UN33_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAGL0K00170g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAR58049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UN33"/>
    <dbReference type="KEGG" id="cgr:9488028"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00170g"/>
    <dbReference type="eggNOG" id="ENOG502S67I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004988_0_0_1"/>
    <dbReference type="InParanoid" id="B4UN33"/>
    <dbReference type="OMA" id="CIAACAS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049451">
        <property type="entry name" value="AWP2-like_YTTT_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20646">
        <property type="entry name" value="Hpf1_C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002827152" description="PA14 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="49"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="1113"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1378"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAR58049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1423" mass="144772" checksum="79D21AD3B0BC9C51" modified="2008-09-23" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIN2</accession>
    <name>ASK1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>DASH complex subunit ASK1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Associated with spindles and kinetochores protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Outer kinetochore protein ASK1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ASK1</name>
        <name type="ordered locus">CAGL0M13079g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the DASH complex consisting of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with a stoichiometry of one copy of each subunit per complex. Multiple DASH complexes oligomerize to form a ring that encircles spindle microtubules and organizes the rod-like NDC80 complexes of the outer kinetochore. DASH complex oligomerization strengthens microtubule attachments (By similarity). On cytoplasmic microtubules, DASH complexes appear to form patches instead of rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449912.1">
        <property type="nucleotide sequence ID" value="XM_449912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIN2"/>
    <dbReference type="SMR" id="Q6FIN2"/>
    <dbReference type="STRING" id="284593.Q6FIN2"/>
    <dbReference type="EnsemblFungi" id="CAGL0M13079g-T">
        <property type="protein sequence ID" value="CAGL0M13079g-T-p1"/>
        <property type="gene ID" value="CAGL0M13079g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891202"/>
    <dbReference type="KEGG" id="cgr:2891202"/>
    <dbReference type="CGD" id="CAL0137427">
        <property type="gene designation" value="CAGL0M13079g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13079g"/>
    <dbReference type="eggNOG" id="ENOG502S2V2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090087_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIN2"/>
    <dbReference type="OMA" id="EICERIM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051987">
        <property type="term" value="P:positive regulation of attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990976">
        <property type="term" value="P:protein transport along microtubule to mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000211314" description="DASH complex subunit ASK1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P35734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9P6S5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="204" mass="22429" checksum="076132A9745E2C5E" modified="2004-07-19" version="1">MDRELERLDQEITLELQKIDGNLSHCFDVITKQVIPRVVAYGQVCDAISDSCEWLGTLCKSSGVVDLKRDVLLERTPVRDSDAHGNAHGDTHGNAHGDAHGEANAERSYGDVAGGEEHNSTVQSEVSDSTMGKYREDDTREQGEDDSVQRQKKRKVSLLIQERYGSSSSVMPSPDKRVPQQSLGSSPVKEQVPLPGTVIHFSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIN3</accession>
    <name>Q6FIN3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial distribution and morphology protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0M13057g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIN3"/>
    <dbReference type="FunCoup" id="Q6FIN3">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIN3"/>
    <dbReference type="KEGG" id="cgr:2891201"/>
    <dbReference type="CGD" id="CAL0137359">
        <property type="gene designation" value="CAGL0M13057g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13057g"/>
    <dbReference type="eggNOG" id="KOG3481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101473_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FIN3"/>
    <dbReference type="OMA" id="KKYDDCF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120010">
        <property type="term" value="P:intermembrane phospholipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0137359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="10123" checksum="9AF02AFE7395ABBE" modified="2004-07-19" version="1">MGNVMSQSFAPECTELKKEYDNCFNEWYMEKFLKGKSIENECTKQWYAYTECVNAALVKQGIKPALDEARKEAPFEQGGKLAGADDDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIT2</accession>
    <name>Q6FIT2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cell division control protein 24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0M11968g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIT2"/>
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        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIT2"/>
    <dbReference type="KEGG" id="cgr:2891257"/>
    <dbReference type="CGD" id="CAL0137379">
        <property type="gene designation" value="CAGL0M11968g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11968g"/>
    <dbReference type="eggNOG" id="KOG3519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007879_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIT2"/>
    <dbReference type="OMA" id="NWRGFNL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120171">
        <property type="term" value="C:Cdc24p-Far1p-Gbetagamma complex"/>
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        <property type="term" value="C:cellular bud neck"/>
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        <property type="term" value="P:chemotropism"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:intracellular signal transduction"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:protein localization to cell cortex"/>
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        <property type="term" value="P:regulation of exit from mitosis"/>
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    </dbReference>
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        <property type="term" value="P:septin ring organization"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="PH_Scd1"/>
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    </dbReference>
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    <dbReference type="FunFam" id="1.20.900.10:FF:000050">
        <property type="entry name" value="Guanine nucleotide exchange factor"/>
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    </dbReference>
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        <property type="entry name" value="Calponin-like domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
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        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
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    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DH_2"/>
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    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="4">
        <location>
            <begin position="182"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="3">
        <location>
            <begin position="329"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="526"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0137379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="95314" checksum="3D522E0014272978" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ27</accession>
    <name>Q6FJ27_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0M09691g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2013-02" db="PDB data bank">
            <title>Solution structure of the RRM domain of the hypothetical protein CAGL0M09691g from Candida glabrata.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Hillerich B."/>
                <person name="Ahmed M."/>
                <person name="Bonanno J.B."/>
                <person name="Chamala S."/>
                <person name="Evans B."/>
                <person name="Lafleur J."/>
                <person name="Hammonds J."/>
                <person name="Washington E."/>
                <person name="Stead M."/>
                <person name="Love J."/>
                <person name="Attonito J."/>
                <person name="Patel H.B."/>
                <person name="Seidel R.D."/>
                <person name="Chook Y.M."/>
                <person name="Rout M.P."/>
                <person name="Girvin M.E."/>
                <person name="Almo S.C."/>
            </authorList>
        </citation>
        <scope>STRUCTURE BY NMR OF 171-283</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="method" value="NMR"/>
        <property type="chains" value="A=171-283"/>
    </dbReference>
    <dbReference type="PDBsum" id="2M4M"/>
    <dbReference type="AlphaFoldDB" id="Q6FJ27"/>
    <dbReference type="BMRB" id="Q6FJ27"/>
    <dbReference type="SMR" id="Q6FJ27"/>
    <dbReference type="STRING" id="284593.Q6FJ27"/>
    <dbReference type="DNASU" id="2891331"/>
    <dbReference type="KEGG" id="cgr:2891331"/>
    <dbReference type="CGD" id="CAL0136449">
        <property type="gene designation" value="CAGL0M09691g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09691g"/>
    <dbReference type="eggNOG" id="ENOG502QWFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024892_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ27"/>
    <dbReference type="OMA" id="TIHEHTP"/>
    <dbReference type="EvolutionaryTrace" id="Q6FJ27"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12721">
        <property type="entry name" value="RRM_Nup53p_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="10">
        <location>
            <begin position="174"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="300"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0136449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG62745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="2M4M"/>
        </source>
    </evidence>
    <sequence length="406" mass="44743" checksum="CC473C36C7CCCDE4" modified="2004-07-19" version="1">MFGNSAGFGSVGDNSSGGSGANRDANNRPSWFQETARRTIPNTVLRREVKSSSNSGEDDNGNRGDSTSTGFNTLTFGAKKHMLLGSSNVSTGGNDHMNPLLMDNSEAPPTVSISDWKREEGLFDLRNTRNENTINTIGTPTFISPISREKSEVSLFDSNSQSRSSSASSIGSESETGNAVVVFGYREAITKQILAYFAQFGEILEDLESELGDTETMRTPGYFFQQAPNRRRISREHGRTWTKLTYANHSSYLRALREHGTIYCGAAIGCVPYKHELISELSRDTYNSMNDVKQTNSISTNQLTQHNQSEVPKSNQTFETKPTNETERNQIKTPSAFGSDNKGNGSISSGRTKRRLSIKDGSSLFLSGTDNIFSTLDGQPTKKRMINRDRSLIGKISGWLFGWNDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJD4</accession>
    <name>Q6FJD4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial distribution and morphology protein 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0M07183g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJD4"/>
    <dbReference type="FunCoup" id="Q6FJD4">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJD4"/>
    <dbReference type="KEGG" id="cgr:2891709"/>
    <dbReference type="CGD" id="CAL0136337">
        <property type="gene designation" value="CAGL0M07183g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07183g"/>
    <dbReference type="eggNOG" id="ENOG502QQJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016236_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FJD4"/>
    <dbReference type="OMA" id="DFLCAEN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900208">
        <property type="term" value="P:regulation of cardiolipin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0136337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG62636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="67046" checksum="7D2B31AD954BE13B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJE9</accession>
    <name>Q6FJE9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M06853g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJE9"/>
    <dbReference type="FunCoup" id="Q6FJE9">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJE9"/>
    <dbReference type="KEGG" id="cgr:2891694"/>
    <dbReference type="CGD" id="CAL0136501">
        <property type="gene designation" value="CAGL0M06853g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06853g"/>
    <dbReference type="eggNOG" id="KOG2602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014798_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FJE9"/>
    <dbReference type="OMA" id="KHPVARF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="6">
        <location>
            <begin position="150"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="466" mass="52170" checksum="A61D5F51EEE3DFB7" modified="2004-07-19" version="1">MMSASDDQLQAELQAELQRFQNFQNGLLNRNLNTPVSVTKVITNGTETIKPQTLQTYLDNTILQATTLKQLVKNADFLSAKLVQHGLAQDVYQNFSTNEKVMSPSAENPIPIIDVISQLNILPVKKFVAKTGTNVGNNEGEGYLEFQLRNVFGNGESLRLDMLRGTAKNSSMLASFVKPINPYHVLDLNIYKHSKNLGNICPLDLHFNGGKMSIKSELGNTQKRINQEWFYEGVTRTTKVTSDHASDTLLFQAGTDFKSSIGHTYAIDTRDSVMAPNRGNLFKLNNEVALGKYWKSQFELSKVQSWFKNDFITTTTTLKGGYLGNFHPDKKTLHINDKFMSGGPNDIRSFQSFGVGPKDLQDAIGGDTFLSYGVSIFSKLPIKKFEDSHFRLHWFFNGGKLINHQNKPVIDTLHDLSRQHSTSVGCGIVLRHPVARFELNFSLPLTVSTEDSLRKGFQFGLGMSFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJH3</accession>
    <name>RS6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein eS6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>40S ribosomal protein S6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPS6A</name>
        <name type="ordered locus">CAGL0H05643g</name>
    </gene>
    <gene>
        <name type="primary">RPS6B</name>
        <name type="ordered locus">CAGL0M06303g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">Phosphorylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447041.1">
        <property type="nucleotide sequence ID" value="XM_447041.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449621.1">
        <property type="nucleotide sequence ID" value="XM_449621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJH3"/>
    <dbReference type="SMR" id="Q6FJH3"/>
    <dbReference type="FunCoup" id="Q6FJH3">
        <property type="interactions" value="1223"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJH3"/>
    <dbReference type="EnsemblFungi" id="CAGL0H05643g-T">
        <property type="protein sequence ID" value="CAGL0H05643g-T-p1"/>
        <property type="gene ID" value="CAGL0H05643g"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0M06303g-T">
        <property type="protein sequence ID" value="CAGL0M06303g-T-p1"/>
        <property type="gene ID" value="CAGL0M06303g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888475"/>
    <dbReference type="GeneID" id="2891669"/>
    <dbReference type="KEGG" id="cgr:2888475"/>
    <dbReference type="KEGG" id="cgr:2891669"/>
    <dbReference type="CGD" id="CAL0130120">
        <property type="gene designation" value="CAGL0H05643g"/>
    </dbReference>
    <dbReference type="CGD" id="CAL0136781">
        <property type="gene designation" value="CAGL0M06303g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H05643g"/>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M06303g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05643g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06303g"/>
    <dbReference type="eggNOG" id="KOG1646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046346_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJH3"/>
    <dbReference type="OMA" id="KPRYKAP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2650:FF:000001">
        <property type="entry name" value="40S ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000137334" description="Small ribosomal subunit protein eS6">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="2">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="236" mass="26937" checksum="157E8AF04E9E710D" modified="2004-07-19" version="1">MKLNIAYPVNGTQKTVEVDDEHRVRVFYDKRIGQEIEGEAVGDEFKGYTFKITGGNDKQGFPMKQGVLLPTRVKLLLAKGHSCYRPRRSGERKRKSVRGAIVGPDLAVLSLVIVKKGEQELEGVTDATVPKRLGPKRANHIRKFFGLTKEDDVRDFVIRREVTKGEKTYTKAPKIQRLVTPQRLQRKRYQRNLKVRNAQAQREAAAEYAQLLAKRLAERKAEKAETRKRRASSLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJK1</accession>
    <name>Q6FJK1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="4">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0M05687g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:60877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="4"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJK1"/>
    <dbReference type="FunCoup" id="Q6FJK1">
        <property type="interactions" value="113"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJK1"/>
    <dbReference type="KEGG" id="cgr:2891641"/>
    <dbReference type="CGD" id="CAL0136967">
        <property type="gene designation" value="CAGL0M05687g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05687g"/>
    <dbReference type="eggNOG" id="KOG3084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase_dom"/>
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        <property type="entry name" value="NAD-CAPPED RNA HYDROLASE NUDT12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42904">
        <property type="entry name" value="NUDIX HYDROLASE, NUDC SUBFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nudix"/>
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        <property type="entry name" value="NUDIX"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="208"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023679"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0136967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG62569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="370" mass="41787" checksum="F51105973CA7BE34" modified="2004-07-19" version="1">MSTFFGDVGLNRVSFLREDTEFIKLAFTSSEAKFIVFVNGEAFYDISSDGKPQLHIETSTSLKGIITTLSPLLETKDLRVDVSGVSITFLGLDDRIDGFSYKGKYKGAPYFGLEFKVDDKTLLTPKDIEFTTSLQRMDRESLFMIDNHSATLYSHAKMYLDWLNKYKFCPGCGSVIYPVHGGTKLQCSSAPEVNCNVRNARVNNVCFPRSDPVIIIAMANEDYSKICLARSFRKHGNFVMYSTIAGFMEPGESIENACAREIWEETGVHCDVDNVKIISSQPWPYPANLMIGCLGIVKFNNKDEIIDLGNDPELMDAQWFDTNEVRAAMDSYKTGWLVPFKDEINFPGETAIAHHLIRHVCKQHQRLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK96</accession>
    <name>Q6FK96_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAGL0L13332g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="284593.Q6FK96"/>
    <dbReference type="KEGG" id="cgr:2890576"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L13332g"/>
    <dbReference type="eggNOG" id="ENOG502QPQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_293552_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK96"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049451">
        <property type="entry name" value="AWP2-like_YTTT_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20646">
        <property type="entry name" value="Hpf1_C"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273309" description="PA14 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="78"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="899"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="901"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1035" mass="111886" checksum="461364C53CC7F1C5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKB5</accession>
    <name>Q6FKB5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L12892g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449329.1">
        <property type="nucleotide sequence ID" value="XM_449329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKB5"/>
    <dbReference type="STRING" id="284593.Q6FKB5"/>
    <dbReference type="KEGG" id="cgr:2890579"/>
    <dbReference type="CGD" id="CAL0135542">
        <property type="gene designation" value="CAGL0L12892g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12892g"/>
    <dbReference type="eggNOG" id="ENOG502RZQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050573_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKB5"/>
    <dbReference type="OMA" id="WYGMLIT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="329" mass="37961" checksum="83E2B3A0628C3656" modified="2004-07-19" version="1">MIGRPGNWFFVVPWIAFIPWYGMLITMLVCWAAQGHPIYWFMHTEQFPVYISDIGATNLRPLFISCAGWQGLGYVITVACEFFQRSGHWPGFLRSSSNKDYSKVEYHETILSKKYFMPPYYTRHERNLIFAAVILGGLGEVALLMCTIFSTALYHHVHLSMVGVFVVLMFFSVCCQTAQYFMMGRRYALFHPLSSENPDAIHALKWYQLAGYKYNKFIISASMKVVWLALAVVWAICFAAISDNSKSACFEWLLAFWFGVLFMIISWDFYMGGRYMYSKYFHQIEAIHGYYKYDSEISSSKESSFASTISEAKLEDSADADEININNQV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKD1</accession>
    <name>NACB_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Nascent polypeptide-associated complex subunit beta</fullName>
            <shortName>NAC-beta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Beta-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">EGD1</name>
        <name type="ordered locus">CAGL0L12540g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Predominantly cytoplasmic, may also transiently localize to the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449313.1">
        <property type="nucleotide sequence ID" value="XM_449313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKD1"/>
    <dbReference type="SMR" id="Q6FKD1"/>
    <dbReference type="FunCoup" id="Q6FKD1">
        <property type="interactions" value="1262"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKD1"/>
    <dbReference type="EnsemblFungi" id="CAGL0L12540g-T">
        <property type="protein sequence ID" value="CAGL0L12540g-T-p1"/>
        <property type="gene ID" value="CAGL0L12540g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890599"/>
    <dbReference type="KEGG" id="cgr:2890599"/>
    <dbReference type="CGD" id="CAL0135912">
        <property type="gene designation" value="CAGL0L12540g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L12540g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12540g"/>
    <dbReference type="eggNOG" id="KOG2240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098726_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FKD1"/>
    <dbReference type="OMA" id="RMQQSVR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006613">
        <property type="term" value="P:cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000001">
        <property type="entry name" value="Transcription factor BTF3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000273505" description="Nascent polypeptide-associated complex subunit beta">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="156" mass="16787" checksum="2B87A51B81946FF3" modified="2004-07-19" version="1">MPIDQEKLAKLQKMSAGNKVGGTRRKQAKKTGSGSAGNKDDTKLHNQLAKLHAVTIDNVAEANFFKDDGKVLHFNKVGVQVAPQHNTSVFYGMAQEKNLQELFPGIISQLGGEAIQALSQLAAQMEKAQANENAGEAKDEAIPELVEGQSFDAEVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKE7</accession>
    <name>ARP6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Actin-like protein ARP6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ARP6</name>
        <name type="ordered locus">CAGL0L12166g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449297.1">
        <property type="nucleotide sequence ID" value="XM_449297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKE7"/>
    <dbReference type="SMR" id="Q6FKE7"/>
    <dbReference type="FunCoup" id="Q6FKE7">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKE7"/>
    <dbReference type="EnsemblFungi" id="CAGL0L12166g-T">
        <property type="protein sequence ID" value="CAGL0L12166g-T-p1"/>
        <property type="gene ID" value="CAGL0L12166g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890687"/>
    <dbReference type="KEGG" id="cgr:2890687"/>
    <dbReference type="CGD" id="CAL0135506">
        <property type="gene designation" value="CAGL0L12166g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12166g"/>
    <dbReference type="eggNOG" id="KOG0680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FKE7"/>
    <dbReference type="OMA" id="FFEEYEC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000040">
        <property type="entry name" value="Actin-like protein ARP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000089113" description="Actin-like protein ARP6">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="421" mass="48032" checksum="2865EBE5502BB8A0" modified="2004-07-19" version="1">MTADQAIVIDNGSYQVKFGLASEVRPRVALNALAKDKYGVTHLSNQVQNIKDISSVVFRRPHELGQLTSWELESCIWDYCLYNPDEFGIDWQSLENRHVVLSETCMTLPELSKNTDQVLFEEYEVDSLYKAPTAAYIPFYTTNENIKTISGKSDHGELDIEEKIEAGKEYNDFSLVIDSGFNCTWVIPIVKGVPYYKAVKKLDVGGRFLNGLLKETISFRHYNVMDESILVNNIKEQCLYVDPVSYFEAFKAKGKNKIDFVLPDFQTSFQGYVRDPKTALPDNAQILTLTDERFSVPEAFFHPEISQSLKPGIIETVLESIYMLPELLRPLMASNIVCMGGNFNLPGFTDRLVSELQRQLPTDWVCRAKISSGDKSLTGWTAMAKFAHTDAYKKARVTKEDYFEHGLDWTTKERFGYQNWV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKK3</accession>
    <name>YTM1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">YTM1</name>
        <name type="ordered locus">CAGL0L10890g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449241.1">
        <property type="nucleotide sequence ID" value="XM_449241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKK3"/>
    <dbReference type="SMR" id="Q6FKK3"/>
    <dbReference type="FunCoup" id="Q6FKK3">
        <property type="interactions" value="1008"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKK3"/>
    <dbReference type="EnsemblFungi" id="CAGL0L10890g-T">
        <property type="protein sequence ID" value="CAGL0L10890g-T-p1"/>
        <property type="gene ID" value="CAGL0L10890g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891016"/>
    <dbReference type="KEGG" id="cgr:2891016"/>
    <dbReference type="CGD" id="CAL0135158">
        <property type="gene designation" value="CAGL0L10890g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10890g"/>
    <dbReference type="eggNOG" id="KOG0313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_0_1"/>
    <dbReference type="InParanoid" id="Q6FKK3"/>
    <dbReference type="OMA" id="DHKYVEF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110136">
        <property type="term" value="P:protein-RNA complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000706">
        <property type="entry name" value="Ribosome biogenesis protein YTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000369582" description="Ribosome biogenesis protein YTM1">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="203"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="324"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="370"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="421"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ubiquitin-like (UBL) domain" evidence="2">
        <location>
            <begin position="8"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sufficient for interaction with ERB1 and association with 66S pre-ribosomes" evidence="1">
        <location>
            <begin position="99"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="457" mass="50850" checksum="9FEDE0B16A34CECC" modified="2004-07-19" version="1">MSTDTSQVKVKFFTREKDESLHVDDVPMYAPISLKRYGLSEIVNHLLESETPIPFDFLIDGELLRTSLQEYLTKKGLSSETTLTVEYTRAVLPPSFLANFNNDDWVSALDVSDDFRHIYSGSYDGVVRTWNMSGKVEKQYSGHTGAVKAVKYISNTRIVSAGNDRSLRLWKTKNDDGSVSNNTGDENDEENIEDGKTLAILEGHKAPVVSLDVASNSRILSASYDNTVALWSTIYKEMTAIDHLEEIQNPNNKISTAAKKRRKLTLKDGTIRRRAPLSLLESHTGPVEQVIFDHGDNTVGYSVSQDHTIKTWDLVTARCIDTKTTSYPLLSIAQMPTLNLLACGSSVRHITLHDPRVSSSAKITQKQLVGHKNFVVGLDTCSENEYLLCSASHDGTVKVWDVRSTSPMYTITRQDPTVEKGVNDKVFAVKWAKSIGIISGGQDKKIQINKGDNIFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKP9</accession>
    <name>Q6FKP9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0L09735g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKP9"/>
    <dbReference type="FunCoup" id="Q6FKP9">
        <property type="interactions" value="578"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891078"/>
    <dbReference type="CGD" id="CAL0135262">
        <property type="gene designation" value="CAGL0L09735g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09735g"/>
    <dbReference type="eggNOG" id="KOG1803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001666_8_2_1"/>
    <dbReference type="InParanoid" id="Q6FKP9"/>
    <dbReference type="OMA" id="WALNDIR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033203">
        <property type="term" value="C:DNA helicase A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043601">
        <property type="term" value="C:nuclear replisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004483">
        <property type="entry name" value="SMUBP-2/Hcs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048761">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00376">
        <property type="entry name" value="IGHMBP2 family helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21138">
        <property type="entry name" value="SMUBP-2_HCS1_1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="200"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0135262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG62165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="695" mass="78391" checksum="DC4995FE4CD0E420" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKS1</accession>
    <name>RPN11_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>26S proteasome regulatory subunit RPN11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPN11</name>
        <name type="ordered locus">CAGL0L09152g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449173.1">
        <property type="nucleotide sequence ID" value="XM_449173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKS1"/>
    <dbReference type="SMR" id="Q6FKS1"/>
    <dbReference type="FunCoup" id="Q6FKS1">
        <property type="interactions" value="1415"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKS1"/>
    <dbReference type="MEROPS" id="M67.001"/>
    <dbReference type="EnsemblFungi" id="CAGL0L09152g-T">
        <property type="protein sequence ID" value="CAGL0L09152g-T-p1"/>
        <property type="gene ID" value="CAGL0L09152g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891118"/>
    <dbReference type="KEGG" id="cgr:2891118"/>
    <dbReference type="CGD" id="CAL0135776">
        <property type="gene designation" value="CAGL0L09152g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L09152g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09152g"/>
    <dbReference type="eggNOG" id="KOG1555">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052991_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FKS1"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902906">
        <property type="term" value="P:proteasome storage granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000213958" description="26S proteasome regulatory subunit RPN11">
        <location>
            <begin position="1"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="JAMM motif" evidence="2">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="306" mass="34424" checksum="A46C785BD840B19B" modified="2004-07-19" version="1">MERLQRLMMNTKVGAADANKDDTKETVYISSIALLKMLKHGRAGVPMEVMGLMLGEFVDEYTVNVVDVFAMPQSGTGVSVEAVDDVFQARMMDMLKQTGRDQMVVGWYHSHPGFGCWLSSVDVNTQKSFEQLNNRAVAVVVDPIQSVKGKVVIDAFRLIDTGALINNQEPRQTTSNSGLMNKANIQALIHGLNRHYYSLNIDYHKTPAETKMLLNLHKEQWQSGLKMQDYQEKETENLEATKRMVAVAQQYSKRIEEEKELSEEELKTRYVGKQDPKKHLAKTAENTLEENTVSVLTAGVNSIAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKT0</accession>
    <name>Q6FKT0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sphingolipid long chain base-responsive protein LSP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LSP1</name>
        <name evidence="3 4" type="ordered locus">CAGL0L08932g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449164.1">
        <property type="nucleotide sequence ID" value="XM_449164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKT0"/>
    <dbReference type="FunCoup" id="Q6FKT0">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKT0"/>
    <dbReference type="GeneID" id="2891095"/>
    <dbReference type="KEGG" id="cgr:2891095"/>
    <dbReference type="CGD" id="CAL0134994">
        <property type="gene designation" value="LSP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08932g"/>
    <dbReference type="eggNOG" id="ENOG502QQ1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046464_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FKT0"/>
    <dbReference type="OMA" id="WGYDNDD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF3">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN LSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0134994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35056" checksum="CE476A5E1F99760B" modified="2004-07-19" version="1">MHRTYSLRSSRAPTAAQMQSPPPPPSSTKSRFFGKGGIASTFRKSTAGNFGPELSRKLSQLVKTEKNVLRALEVVSNERRAAARQLSLWGSENDDDVSDVTDKLGVLIFELGELQDQFIDKYDQYRVTMKSIRNIEASVQPSRDRKEKITDEIAHLKYKDPSSTKIPVLEQELVRAEAESLVAEAQLSNITREKLKAAFNYQFDSIRELAEKFALIAGYGKALLELLDDSPVTPGETRPAYDGYDASRQIIMDAEGALEAWTLDVAAVKPTLSFHQTVDDVYEEEDGEEVQEGEEGQQWEEEQQEEHHEGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKU6</accession>
    <name>Q6FKU6_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0L08536g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449148.1">
        <property type="nucleotide sequence ID" value="XM_449148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKU6"/>
    <dbReference type="KEGG" id="cgr:2890623"/>
    <dbReference type="CGD" id="CAL0136164">
        <property type="gene designation" value="CAGL0L08536g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08536g"/>
    <dbReference type="HOGENOM" id="CLU_2704572_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKU6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0136164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="73" mass="8489" checksum="10A2336E022EFF28" modified="2004-07-19" version="1">MKIPYRYLRFLKHTPIRGGTQLDLIEMSTVELLVFTMLSRVVNISIVRFSKNWSNRVRTGFTSLAAPIARIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL50</accession>
    <name>Q6FL50_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0L06182g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL50"/>
    <dbReference type="FunCoup" id="Q6FL50">
        <property type="interactions" value="899"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL50"/>
    <dbReference type="KEGG" id="cgr:2890752"/>
    <dbReference type="CGD" id="CAL0135734">
        <property type="gene designation" value="CAGL0L06182g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06182g"/>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021713_3_3_1"/>
    <dbReference type="InParanoid" id="Q6FL50"/>
    <dbReference type="OMA" id="NQIKWCR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000705">
        <property type="term" value="P:achiasmate meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071475">
        <property type="term" value="P:cellular hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044818">
        <property type="term" value="P:mitotic G2/M transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905477">
        <property type="term" value="P:positive regulation of protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061586">
        <property type="term" value="P:positive regulation of transcription by transcription factor localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="381"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0135734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="495" mass="56614" checksum="6946CD20B143E891" modified="2004-07-19" version="1">MAQDNFDFKFSQCFGDKADIVVTEADIITAVEFDHTGDFLATGDRGGRVVLFERGNDTKHCEYKFLTEFQSHDAEFDYLKSLEIEEKINQIKWLKPTNKSHFLLSTNDKTIKLWKVYEKNIKLVSSNNLSENSRRRSGAGLSSNNSLMLQSLKLPQLSQHDKIIAAAPKRIYGNAHTYHINSISPNSDQETFISADDLRVNLWNLDIPDQSFNVVDIKPANMEELTEVITSAEFHPQQCNLFMYSSSKGTIKLCDMRQNALCDNKSKIFEEYLDPMNHNFFTEITSSISDIKFSPNGRYIASRDYLTVKIWDINMDTKPIKTINIHDQLKERLSDTYENDAIFDKFEVCFSGDSSSVMTGSYNNNFMIYPNVVTSYDDAMQDSAKGTESQVKNNERPFDTQKSKNSITRRNDSNNSGLRDQAINNEHTDEIVLQADKSAFRNKRFASMNSSAAIKNKEWDDDIDFKKSILHFSWHPKENSIAIAATNNLFIFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL97</accession>
    <name>Q6FL97_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L05126g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL97"/>
    <dbReference type="FunCoup" id="Q6FL97">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL97"/>
    <dbReference type="KEGG" id="cgr:2890722"/>
    <dbReference type="CGD" id="CAL0135816">
        <property type="gene designation" value="CAGL0L05126g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05126g"/>
    <dbReference type="eggNOG" id="KOG2909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017554_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FL97"/>
    <dbReference type="OMA" id="VMIWIHV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="391" mass="44227" checksum="963F131BE1DC48BC" modified="2004-07-19" version="1">MATALYTANDFFLVSLPGNAKPASGQADVDTWLKNNLLGGRTFVSDFKIPEFKIGSLDNLLVESEDLSKIDNQVGSSVSKIVEILSGMNEASTNDYKTIPINNMPIPEYLEHFEWQTRKFKLDKSIKELMSNLSDEASQLDLDVRATYTNYTNAKSNLAAAERKKTGDLSVRSLHDIVKSDDFILDSEYLTTVLIAVPKNLKADFEKTYETLSKNVVPGSAGIIAKDDDYILYNVHLFKRNAQEFTTAAREKKFIPREFNYSEELIDQLKREHDSAASLEQSLRIQLVRLAKTAFVDVFVIWFHIKALRVYVESVLRYGLPPHFIIKIIAVPPKNVTKCKQELVDAFGFLGGNAFARDKKGKISKDDTSLHQYANLVDADYEPFVFYHIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLC2</accession>
    <name>Q6FLC2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0L04532g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLC2"/>
    <dbReference type="FunCoup" id="Q6FLC2">
        <property type="interactions" value="1354"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLC2"/>
    <dbReference type="KEGG" id="cgr:2890642"/>
    <dbReference type="CGD" id="CAL0135140">
        <property type="gene designation" value="CAGL0L04532g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04532g"/>
    <dbReference type="eggNOG" id="KOG1148">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_1"/>
    <dbReference type="InParanoid" id="Q6FLC2"/>
    <dbReference type="OMA" id="TWCIYPM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000007">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2420:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000015">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000183">
        <property type="entry name" value="Glutaminyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042559">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="15">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="14">
        <location>
            <begin position="159"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="242"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="13">
        <location>
            <begin position="559"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="672"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0135140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG61942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="795" mass="91325" checksum="4082A3213F0B104D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLD6</accession>
    <name>Q6FLD6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0L04224g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLD6"/>
    <dbReference type="FunCoup" id="Q6FLD6">
        <property type="interactions" value="793"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLD6"/>
    <dbReference type="KEGG" id="cgr:2890772"/>
    <dbReference type="CGD" id="CAL0136114">
        <property type="gene designation" value="CAGL0L04224g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04224g"/>
    <dbReference type="eggNOG" id="KOG3203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FLD6"/>
    <dbReference type="OMA" id="HKPIYTP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000007">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="167" mass="18876" checksum="1A6F08DEF3EAA7F0" modified="2004-07-19" version="1">MSQKVGHTGLAFARLWHHVDLAKDKRTLGRVASSIAVTLIGKHKPVYHPSQDCGDYVVVTNCQKVRITGKKFEQKTYWSHSTKPGNLKLTTMKTMAENKGYGELLKKAVSGMLPKNRLRKVRLARLKVFDGAEHPYGDNFTAYALKQPKVQKLIESRQERTQVSQEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-10-25" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLF3</accession>
    <name>DBP2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP2</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP2</name>
        <name type="ordered locus">CAGL0L03846</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with polysomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448941.1">
        <property type="nucleotide sequence ID" value="XM_448941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLF3"/>
    <dbReference type="SMR" id="Q6FLF3"/>
    <dbReference type="FunCoup" id="Q6FLF3">
        <property type="interactions" value="1323"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLF3"/>
    <dbReference type="EnsemblFungi" id="CAGL0L03846g-T">
        <property type="protein sequence ID" value="CAGL0L03846g-T-p1"/>
        <property type="gene ID" value="CAGL0L03846g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890547"/>
    <dbReference type="KEGG" id="cgr:2890547"/>
    <dbReference type="CGD" id="CAL0135480">
        <property type="gene designation" value="CAGL0L03846g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L03846g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03846g"/>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_9_1"/>
    <dbReference type="InParanoid" id="Q6FLF3"/>
    <dbReference type="OMA" id="STMPKFE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000054995" description="ATP-dependent RNA helicase DBP2">
        <location>
            <begin position="1"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="141"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="331"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA-binding RGG-box" evidence="1">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="264"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="501"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="544" mass="60705" checksum="E179371910213518" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLK3</accession>
    <name>Q6FLK3_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L02761g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLK3"/>
    <dbReference type="FunCoup" id="Q6FLK3">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLK3"/>
    <dbReference type="KEGG" id="cgr:2890864"/>
    <dbReference type="CGD" id="CAL0135808">
        <property type="gene designation" value="CAGL0L02761g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02761g"/>
    <dbReference type="eggNOG" id="KOG0286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_34_1"/>
    <dbReference type="InParanoid" id="Q6FLK3"/>
    <dbReference type="OMA" id="PLDSQWV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120171">
        <property type="term" value="C:Cdc24p-Far1p-Gbetagamma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031680">
        <property type="term" value="C:G-protein beta/gamma-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005937">
        <property type="term" value="C:mating projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031682">
        <property type="term" value="F:G-protein gamma-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043577">
        <property type="term" value="P:chemotropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061951">
        <property type="term" value="P:establishment of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903260">
        <property type="term" value="P:protein localization to mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="378"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="25"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="419" mass="45704" checksum="489DAB7993E8AF35" modified="2004-07-19" version="1">MNTIGTGNIISQYLNTSNNSSDELKVVVQEQIEKARNETKDLQNQIEKVKARKQDTNLLEMTASVPAITPGAINLKPVGILKGHTNKIADFRWSRDSKLILSASQDGFMIVWDSLTGLKRSAIPLDSQWVLTCALSPSGALAASAGLNNNCTIYRMPRGSAVQQNVTSIFKGHTGYISGVEFVSESRVVTSSGDMTCALWDIPKAKRVREYSDHLGDVLAISIPVTNLSKNNMFASCGSDGYTFIWDVRSPSAVQQFSIGSCDSNCLKFFPDGNSVAVGNDDGTISLFDLRADCTIALYSINDRGSPLQKENVFLNSNEYQSSSSSPKSPISLATNYFEDRGVISLDFSGSGRLMYSCYINLGCQVWDVLKGEVVYSLEGHGNRLAGVKCSPDGMAICTGSWDQTLKLWTPQYEKTKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLL4</accession>
    <name>Q6FLL4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAGL0L02519g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLL4"/>
    <dbReference type="KEGG" id="cgr:2890855"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_27_4_1"/>
    <dbReference type="InParanoid" id="Q6FLL4"/>
    <dbReference type="OMA" id="RIPYPML"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="40"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="529" mass="58000" checksum="A4416CD6F5C84FD6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLN5</accession>
    <name>Q6FLN5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0L02057g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLN5"/>
    <dbReference type="FunCoup" id="Q6FLN5">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLN5"/>
    <dbReference type="KEGG" id="cgr:2890681"/>
    <dbReference type="CGD" id="CAL0136138">
        <property type="gene designation" value="CAGL0L02057g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02057g"/>
    <dbReference type="eggNOG" id="KOG2593">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035744_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FLN5"/>
    <dbReference type="OMA" id="DAIKWKV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001113">
        <property type="term" value="P:transcription open complex formation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000459">
        <property type="entry name" value="TFA1p TFIIE large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0136138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="466" mass="53312" checksum="2EC92DF7BE5E1318" modified="2004-07-19" version="1">MDVPIDEIVKNLLKFVVRGFYGGSYVLVLDAIIYHSVLVEEDLKQLLSINKTELGPLIARLRSDRLVSTHKQREYPPNSKSVERCYYYIKYPHAVDSIKWKVHQLVQRMKEDLDKNSEPNGYMCPICLTKYTQLEAIQLLNYERTEFLCSLCDEPLIEDDSGKKNKEKQDKLNRLMDQIQPIIDYLKKIDDSRIEENTFELALARLIPPQNQLNAAYTFNPKKGSTMFKPGETTLDANSIMGNSLGNDSSRRAGANSQATLHVNITTANDEIVQRQLQERQAEEKRKQNAVPEWHQQSTIGKTALGRLDSDEEFDPQTTQQALQSTMGGGSDVVDEESTYGYNNNLTANQREEKENERTLNEYYAALARKQAKAKKEEEEEEEEEMEDVNDDNVDGNDDDEDGFEDVVTGNNGTTQNQSEDSEDNEDIAAFEDEFEDVMDESDEKKISNGEDKNKDDDMDIEFEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLP1</accession>
    <name>Q6FLP1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">UGP1</name>
        <name evidence="10 11" type="ordered locus">CAGL0L01925g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448853.1">
        <property type="nucleotide sequence ID" value="XM_448853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLP1"/>
    <dbReference type="FunCoup" id="Q6FLP1">
        <property type="interactions" value="982"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLP1"/>
    <dbReference type="GeneID" id="2890675"/>
    <dbReference type="KEGG" id="cgr:2890675"/>
    <dbReference type="CGD" id="CAL0135786">
        <property type="gene designation" value="UGP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01925g"/>
    <dbReference type="eggNOG" id="KOG2638">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023632_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FLP1"/>
    <dbReference type="OMA" id="KEYCFLS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
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        <property type="term" value="P:glycogen biosynthetic process"/>
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        <property type="term" value="P:trehalose biosynthetic process"/>
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    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
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    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
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    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
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    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
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        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
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        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="391"/>
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        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0135786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="502" mass="55985" checksum="3E7F19DF44500A4E" modified="2004-07-19" version="1">MSTAKKHTKTHSTYAFESNTNSVAASQMRNALNKLADSIGSEHGDDARTRFENELDSFFTLFRRYLVEKSSSNTLEWDKIKSPNPEEVVRYDTINSQAENVSSLSKLAVLKLNGGLGTSMGCVGPKSVIEVREGNSFLDLSVRQIEHLNRQYDSDVPLLLMNSFNTDKDTEHLIKKYSANRIRIRSFNQSRFPRVYKDSMLPVPETYNDPKDAWYPPGHGDLFESLHASGELDALIAQGREILFVSNGDNLGATVDLKILNHMIETGAEYIMELTDKTRADVKGGTLISYDGQVRLLEVAQVPKEHIDEFKNIRKFTNFNTNNLWINLKAVKRLVESSALEMEIIPNQKTITRGGQEINVLQLETACGAAIRHFSGAHGVVVPRSRFLPVKTCSDLLLVKSDLFYLQHGALKLDPSRFGPNPLIKLGSHFKKVSDFSARIPHIPKLVELDHLTITGNVFLGKGVTLRGTVIIVCSDGQKIDIPNGSVLENVVITGNLQILEH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2025-06-18" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLP2</accession>
    <name>RGT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Glucose transport transcription regulator RGT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Restores glucose transport protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RGT1</name>
        <name type="ordered locus">CAGL0L01903g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose. In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator. In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EDS1/RGT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448852.1">
        <property type="nucleotide sequence ID" value="XM_448852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLP2"/>
    <dbReference type="SMR" id="Q6FLP2"/>
    <dbReference type="FunCoup" id="Q6FLP2">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLP2"/>
    <dbReference type="EnsemblFungi" id="CAGL0L01903g-T">
        <property type="protein sequence ID" value="CAGL0L01903g-T-p1"/>
        <property type="gene ID" value="CAGL0L01903g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890674"/>
    <dbReference type="KEGG" id="cgr:2890674"/>
    <dbReference type="CGD" id="CAL0135076">
        <property type="gene designation" value="RGT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01903g"/>
    <dbReference type="eggNOG" id="ENOG502QRVJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006525_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLP2"/>
    <dbReference type="OMA" id="WFRNSLE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000408013" description="Glucose transport transcription regulator RGT1">
        <location>
            <begin position="1"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="49"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="412"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="489"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="789"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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    </feature>
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    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1287" mass="143425" checksum="AA6CDBD5E6AFDA3A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM76</accession>
    <name>Q6FM76_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rho-type GTPase-activating protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0K10318g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM76"/>
    <dbReference type="FunCoup" id="Q6FM76">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM76"/>
    <dbReference type="KEGG" id="cgr:2890118"/>
    <dbReference type="CGD" id="CAL0134369">
        <property type="gene designation" value="CAGL0K10318g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10318g"/>
    <dbReference type="eggNOG" id="KOG1453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003874_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FM76"/>
    <dbReference type="OMA" id="RYAKTKR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF121">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="74"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="698"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="232"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="415"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="494"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="917" mass="104011" checksum="9C643B6BBA9AF3FB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMD3</accession>
    <name>Q6FMD3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transferrin receptor-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0K08976g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMD3"/>
    <dbReference type="FunCoup" id="Q6FMD3">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMD3"/>
    <dbReference type="KEGG" id="cgr:2890293"/>
    <dbReference type="CGD" id="CAL0134329">
        <property type="gene designation" value="CAGL0K08976g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08976g"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005688_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FMD3"/>
    <dbReference type="OMA" id="RIIDPIY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00538">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF72">
        <property type="entry name" value="ZINC METALLOPROTEASE TRE2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="423"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="3">
        <location>
            <begin position="658"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0134329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG61574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="89764" checksum="89F7A0337067392B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMH3</accession>
    <name>Q6FMH3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0K08052g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMH3"/>
    <dbReference type="FunCoup" id="Q6FMH3">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMH3"/>
    <dbReference type="KEGG" id="cgr:2890339"/>
    <dbReference type="CGD" id="CAL0134127">
        <property type="gene designation" value="CAGL0K08052g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08052g"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071677_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMH3"/>
    <dbReference type="OMA" id="QEINICC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045471">
        <property type="term" value="P:response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0134127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="305" mass="35072" checksum="AAAD2DCDB94EB9F4" modified="2004-07-19" version="1">MVSKVCAICLEDICGKSSTSYLKPCGHEYHSDCIRKWHGHAEDLKCPMCRIDAEELVVKLYGCAEKIIDLQKGFAVNQVVNHVINTEPDLIDELAEALDNNLHISELRTDTQVEPEAPPSRPRLLQCGICGDQDDLVLEHYCEECQTLYHGSCLRVLAIETGERTDWCVCVDCRKELISRNDRLVIQNSQLASRDDGSLMYDTNNTMVFEGQLREKNSVRAEQIYRDCYLESLKKTKTNIQKHVRKCLDTYYHSGKIDHMEYTRINKTVSRKLYTLSNYTYSQELNYDHLAKQHIETELGTPLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMM2</accession>
    <name>Q6FMM2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Tyrosyl-DNA phosphodiesterase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0K06875g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMM2"/>
    <dbReference type="FunCoup" id="Q6FMM2">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMM2"/>
    <dbReference type="KEGG" id="cgr:2890410"/>
    <dbReference type="CGD" id="CAL0133853">
        <property type="gene designation" value="CAGL0K06875g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06875g"/>
    <dbReference type="eggNOG" id="KOG2031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010413_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FMM2"/>
    <dbReference type="OMA" id="AHSKFYM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09194">
        <property type="entry name" value="PLDc_yTdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09196">
        <property type="entry name" value="PLDc_yTdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0133853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG61483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="63486" checksum="32B91B6679C6C210" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMS8</accession>
    <name>Q6FMS8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0K05533g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMS8"/>
    <dbReference type="FunCoup" id="Q6FMS8">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMS8"/>
    <dbReference type="KEGG" id="cgr:2890490"/>
    <dbReference type="CGD" id="CAL0133885">
        <property type="gene designation" value="CAGL0K05533g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05533g"/>
    <dbReference type="eggNOG" id="KOG2837">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030065_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FMS8"/>
    <dbReference type="OMA" id="NHEDERD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0133885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="241" mass="28220" checksum="1F61C40A3C4C0672" modified="2004-07-19" version="1">MSEDFNSAKFLNKQLKARGLQKLRFYCQVCNKQCRDQNGFKSHVKSPSHLKNISTVTQDDILEFTKLFEENFLNTLKTNHGEKKIAVNKLYNEIIKDRDHIHMNATSFKSLTGFIKYLSKEGKIKVYDDNIGDMPEDQVDLTQLNISFIDNSDTNLRRKEKLQEIEAEELTESKLEEYLRTKRQLREQEEEESDVQDTDLGSNTDIQRDNLTNLKIQLKKTKIKQNKVKKPLNKNKNNVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMX7</accession>
    <name>Q6FMX7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDENN FLCN/SMCR8-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K04411g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMX7"/>
    <dbReference type="FunCoup" id="Q6FMX7">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMX7"/>
    <dbReference type="KEGG" id="cgr:2889996"/>
    <dbReference type="CGD" id="CAL0134229">
        <property type="gene designation" value="CAGL0K04411g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04411g"/>
    <dbReference type="eggNOG" id="KOG3715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035854_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FMX7"/>
    <dbReference type="OMA" id="THFCDKH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990877">
        <property type="term" value="C:FNIP-folliculin RagC/D GAP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="1">
        <location>
            <begin position="71"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="283" mass="31676" checksum="030B1059FF287CEF" modified="2004-07-19" version="1">MILISLGHFCDIHGPTIIIVTQEGEIGNSGNELLLPDYPTESYCESCMVKIPDCDGSDENGADVDTEAEVSTTDTISENTLLPASNVPRSIRSKLGEKSFVSSQYSAIRYQLLTSMIRKAFSEETMIYDGSPSVFYDESKGLNLVMGFKLHDPNARGNERRYCLILTIESVDETNAMGLIAAHWHFIVGGFSMMINAIKEKHAQNNDGLESNHDLQKNFTQDIGNYLRANKGKCARNLSELTNDKFTFLRIHKWNTYMIDTLCSKLQRADQSSVIKERSKHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMZ9</accession>
    <name>Q6FMZ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic recombination protein REC114</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K03905g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61356.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMZ9"/>
    <dbReference type="FunCoup" id="Q6FMZ9">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMZ9"/>
    <dbReference type="KEGG" id="cgr:2890145"/>
    <dbReference type="CGD" id="CAL0134759">
        <property type="gene designation" value="CAGL0K03905g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03905g"/>
    <dbReference type="eggNOG" id="ENOG502S70J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_891636_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMZ9"/>
    <dbReference type="OMA" id="NANHNIV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61356.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="41384" checksum="A92D031F408FEF32" modified="2008-09-23" version="2">MNGYKECLRLSVMRYSKYQGQISAPHGFASAFAPLDLTLWSHITGTSECPMFLVLLVTSDSKACRLKILSMQIEHEDILIKDNTIVSFVQFSAQSPVISCKYLTQVDKFQYLNRFQIEFNSNEYMVAYGILTQIGFKIKKARRVNSEENEVQDKLATSQQSQMLIFSQRENIIPSPNYKNINNLNYPSGDPPRHRQDLCSTHKNVDTTLLNSLPLVHIGDNLRNSTSSSDKTPPIKKGGNQEIVNANHNIVKLSDKIHPYIIPNESAQLIIPEIKFGNISDIIDSENNAPLNKQFLTTVNTEEICNTNTTDVTKHTKPVITKRLLKRKLRDKLFMIWVRRIEKYFINIEKKSKHKSSRKHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN54</accession>
    <name>Q6FN54_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K02651g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448340.1">
        <property type="nucleotide sequence ID" value="XM_448340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN54"/>
    <dbReference type="FunCoup" id="Q6FN54">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN54"/>
    <dbReference type="KEGG" id="cgr:2890267"/>
    <dbReference type="CGD" id="CAL0134257">
        <property type="gene designation" value="CAGL0K02651g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02651g"/>
    <dbReference type="eggNOG" id="ENOG502QUGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020549_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN54"/>
    <dbReference type="OMA" id="RNPGIVN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140299">
        <property type="term" value="F:molecular sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006821">
        <property type="term" value="P:chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001225">
        <property type="term" value="P:regulation of chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="69940" checksum="44DFC991861D705C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNB1</accession>
    <name>NPC2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
            <shortName>PG/PI-TP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NPC2</name>
        <name type="ordered locus">CAGL0K01353g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448283.1">
        <property type="nucleotide sequence ID" value="XM_448283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNB1"/>
    <dbReference type="SMR" id="Q6FNB1"/>
    <dbReference type="FunCoup" id="Q6FNB1">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNB1"/>
    <dbReference type="EnsemblFungi" id="CAGL0K01353g-T">
        <property type="protein sequence ID" value="CAGL0K01353g-T-p1"/>
        <property type="gene ID" value="CAGL0K01353g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890053"/>
    <dbReference type="KEGG" id="cgr:2890053"/>
    <dbReference type="CGD" id="CAL0134291">
        <property type="gene designation" value="CAGL0K01353g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01353g"/>
    <dbReference type="eggNOG" id="KOG4680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097982_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FNB1"/>
    <dbReference type="OMA" id="HQTYDLC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000019877" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000019878" description="Phosphatidylglycerol/phosphatidylinositol transfer protein">
        <location>
            <begin position="44"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="185" mass="20113" checksum="7E1E6975A188D240" modified="2004-07-19" version="1" precursor="true">MQVKSLISSVALWGCAFTVANPIIGWGIGDVDKKAPMPPGFGETKPIPGDSPLKMCDIAEGQLLEITKLDLVPNPPKRGSKLVIKASGEIFETIEEGAYVDVEVRLGYIKLLTQTYDLCEILEDNDVDGLTCPIKKGKYDNLSKDVDIPQEVPPGKYLVTARAYTNDDDLITCITGEVYFPPPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNI8</accession>
    <name>Q6FNI8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0J11352g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNI8"/>
    <dbReference type="FunCoup" id="Q6FNI8">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNI8"/>
    <dbReference type="MEROPS" id="C19.088"/>
    <dbReference type="KEGG" id="cgr:2889496"/>
    <dbReference type="CGD" id="CAL0133702">
        <property type="gene designation" value="CAGL0J11352g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11352g"/>
    <dbReference type="eggNOG" id="KOG1870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016013_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FNI8"/>
    <dbReference type="OMA" id="WCTYDDE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000146">
        <property type="entry name" value="Ubiquitin-specific protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="385"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="727"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0133702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="771" mass="87634" checksum="6FAC7E0997D93FB1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNL0</accession>
    <name>Q6FNL0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxyacyl-thioester dehydratase type 2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0J10868g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNL0"/>
    <dbReference type="FunCoup" id="Q6FNL0">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNL0"/>
    <dbReference type="KEGG" id="cgr:2889513"/>
    <dbReference type="CGD" id="CAL0133760">
        <property type="gene designation" value="CAGL0J10868g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10868g"/>
    <dbReference type="eggNOG" id="ENOG502S5QU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028690_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FNL0"/>
    <dbReference type="OMA" id="MWAGSQF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026223">
        <property type="entry name" value="Htd2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02096">
        <property type="entry name" value="HTDHYDRTASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0133760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32735" checksum="CEAEC24FD8EE9701" modified="2004-07-19" version="1">MSWKSLHWLHKDIISFEKNQAFNNLFKNAVRTNIKMTENIQLADNLLYFNPVDSDLDPDGYFSYQSPSSLISTLQRYRLRRWTNGEITNNKPLVPGKEYSCHERIKFIKPIGDSCFVSLQRTIRDSNDVTAITEDRTLQYTNRIGDRFSALEEMAQETKQYEAVAGINISDLDIVKYCQMTNNPHRIHWDRDYCRTQEGIKDILVPGPLITQIMARLLCPNSASLITRIKYKTVSPIYPFTPLRAIKVSPTALWLADESKLYAKMEIKESHRDIMPDQHLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNP7</accession>
    <name>Q6FNP7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J10054g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNP7"/>
    <dbReference type="FunCoup" id="Q6FNP7">
        <property type="interactions" value="784"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNP7"/>
    <dbReference type="KEGG" id="cgr:2889407"/>
    <dbReference type="CGD" id="CAL0133630">
        <property type="gene designation" value="CAGL0J10054g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10054g"/>
    <dbReference type="eggNOG" id="KOG0681">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008246_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FNP7"/>
    <dbReference type="OMA" id="YPFTEHV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="418"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0133630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="754" mass="87833" checksum="D728D2E5ADA7623D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNS6</accession>
    <name>Q6FNS6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J09394g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448118.1">
        <property type="nucleotide sequence ID" value="XM_448118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNS6"/>
    <dbReference type="SMR" id="Q6FNS6"/>
    <dbReference type="FunCoup" id="Q6FNS6">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNS6"/>
    <dbReference type="KEGG" id="cgr:2889930"/>
    <dbReference type="CGD" id="CAL0129853">
        <property type="gene designation" value="CAGL0J09394g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09394g"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_3_1"/>
    <dbReference type="InParanoid" id="Q6FNS6"/>
    <dbReference type="OMA" id="IGTGTRW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004032">
        <property type="term" value="F:aldose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051268">
        <property type="term" value="F:alpha-keto amide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051269">
        <property type="term" value="F:alpha-ketoester reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042180">
        <property type="term" value="P:ketone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0129853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="311" mass="35710" checksum="560B24A3E4BDB1D7" modified="2004-07-19" version="1">MVKQEFFKLNNGHEMPGVAIVGTGTKWHKVNETDENFSQTLVDQLKYALSLPGVVHLDAAEFYMTYREVGRALAETSKPRDEIFITDKYWTLSKVTENPIVGLETGLKRLGLEYVDLYLLHSPFISKETNGFSLEEAWGMMEELYHSGKAKNIGVSNFAKEDLERVLKVCKVKPQVNQIEFNAFLQNQTPGIYNFCKQNDIQLAAYSPLGPLQKKPADGNSQPFYSYINKLAQHYNKTPGQVLLRWVTKRGVVAVTTSEKKERIKQAQEIFEFDLKDDEVTEITKLGLDHEPLRLYWHDQYNKYNSESQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNT9</accession>
    <name>Q6FNT9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0J09108g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNT9"/>
    <dbReference type="FunCoup" id="Q6FNT9">
        <property type="interactions" value="1361"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNT9"/>
    <dbReference type="KEGG" id="cgr:2889943"/>
    <dbReference type="CGD" id="CAL0133622">
        <property type="gene designation" value="CAGL0J09108g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09108g"/>
    <dbReference type="eggNOG" id="KOG2042">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003224_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FNT9"/>
    <dbReference type="OMA" id="SNAFMTN"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071361">
        <property type="term" value="P:cellular response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16657">
        <property type="entry name" value="RING-Ubox_UBE4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="11">
        <location>
            <begin position="872"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0133622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="947" mass="109299" checksum="6E056E57431104F0" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNV3</accession>
    <name>Q6FNV3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="7">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0J08800g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine and inosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNV3"/>
    <dbReference type="FunCoup" id="Q6FNV3">
        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNV3"/>
    <dbReference type="KEGG" id="cgr:2889677"/>
    <dbReference type="CGD" id="CAL0133266">
        <property type="gene designation" value="CAGL0J08800g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08800g"/>
    <dbReference type="eggNOG" id="KOG3984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FNV3"/>
    <dbReference type="OMA" id="EGVYAQF"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047724">
        <property type="term" value="F:inosine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070635">
        <property type="term" value="F:nicotinamide riboside hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046115">
        <property type="term" value="P:guanosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006148">
        <property type="term" value="P:inosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019358">
        <property type="term" value="P:nicotinate nucleotide salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000004">
        <property type="entry name" value="Purine nucleoside phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006054">
        <property type="entry name" value="PRK08202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="METHYLTHIOADENOSINE/PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904:SF9">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="9">
        <location>
            <begin position="39"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="99"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0133266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="315" mass="35030" checksum="4E2B421F0A2E3EBE" modified="2004-07-19" version="1">MNTNWDLGEERVKIEKASEYLSERFQERFQNEKFEPRALIICGSGLSGIPDKLNKDKLEPLVIPYELIPGFKRSTVPGHSGNLVFGIMNDYPVVLMSGRLHGYEGNTMQETVFPIRVLHHFSKGGIKTLIVTNAAGGINSEFKPGDIMCIYDHINFPGLAGLHPLKGPNFDDIGPRFLALSDAYSHDLRKLLFQTHNELKMDRPLHEGTYFFASGPTFETRAESRMIRILGGDSVGMSTVPEVIVARHCGWDVLALSLITNVAVIDHPPSGKIDTPVPMDYGKASHAEVLENGRIASKDVETLISTFVGKLHYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP37</accession>
    <name>Q6FP37_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">37S ribosomal protein MRP51, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0J06930g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP37"/>
    <dbReference type="FunCoup" id="Q6FP37">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP37"/>
    <dbReference type="KEGG" id="cgr:2889625"/>
    <dbReference type="CGD" id="CAL0132786">
        <property type="gene designation" value="CAGL0J06930g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06930g"/>
    <dbReference type="eggNOG" id="ENOG502R4KN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063080_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP37"/>
    <dbReference type="OMA" id="KNAPGKH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018156">
        <property type="entry name" value="MRPL51_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38572" checksum="BC5091CF010E8328" modified="2004-07-19" version="1">MSLSNMLRASRLAQVYKSSKPLSTGLKIAPTHQVIETKPALLKFHEWGLKSAIPSKVKTQYLMYKELDTLERLTDFEPRGGANWNRIRVQEFGLSPRYNANTKNPLFNKEHYDFSSLNEVFTKFFFEKQQHGSMKYGSLSESRKLFIKNVRQEFKEWLVAKYPEAILNQSFTKPDNMLTYGKEFLQSYNNRSSSKLNSPDTMIGTGGLTYALKGRLRNSPNGVIQKHIVPGRFVAPTNDNKIAAIGGFVANAASSVISAQPQKWVSNRDKIYPFEVSNLSVNNGQITLDAKGTMLNKPEQKRLRRNHYPKPLYGNRYSTGERKSDVAESLKAILEFNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP69</accession>
    <name>Q6FP69_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SKO1</name>
        <name evidence="7 8" type="ordered locus">CAGL0J06182g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447975.1">
        <property type="nucleotide sequence ID" value="XM_447975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP69"/>
    <dbReference type="FunCoup" id="Q6FP69">
        <property type="interactions" value="858"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP69"/>
    <dbReference type="GeneID" id="2889579"/>
    <dbReference type="KEGG" id="cgr:2889579"/>
    <dbReference type="CGD" id="CAL0132822">
        <property type="gene designation" value="SKO1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06182g"/>
    <dbReference type="eggNOG" id="KOG1414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027901_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP69"/>
    <dbReference type="OMA" id="HNAQTES"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="391"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="100"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="219"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="319"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00338"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0132822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="513" mass="53783" checksum="1E4434093F758F43" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP77</accession>
    <name>Q6FP77_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J06006g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG60918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP77"/>
    <dbReference type="KEGG" id="cgr:2889776"/>
    <dbReference type="CGD" id="CAL0132766">
        <property type="gene designation" value="CAGL0J06006g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06006g"/>
    <dbReference type="eggNOG" id="KOG1760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130032_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP77"/>
    <dbReference type="OMA" id="KFGRAIN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0132766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="129" mass="15302" checksum="E71CF60A7268C39D" modified="2004-07-19" version="1">MELLPEGKKNNIEVTFADQQKINEFSKLIMRKDALEAELKKERQEKEYLEDVSLEIELIDEDEEVQYKMGEVFVFLKQSKVVEQLEKDTEIIDEKISQLESKQDDLEDRIKELKTSLYAKFGDNINLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP92</accession>
    <name>Q6FP92_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">INN1</name>
        <name evidence="3 4" type="ordered locus">CAGL0J05676g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447952.1">
        <property type="nucleotide sequence ID" value="XM_447952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP92"/>
    <dbReference type="FunCoup" id="Q6FP92">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP92"/>
    <dbReference type="GeneID" id="2889801"/>
    <dbReference type="KEGG" id="cgr:2889801"/>
    <dbReference type="CGD" id="CAL0133094">
        <property type="gene designation" value="INN1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05676g"/>
    <dbReference type="eggNOG" id="ENOG502QSUF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_673016_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP92"/>
    <dbReference type="OMA" id="TRFHFAN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044697">
        <property type="term" value="C:HICS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990344">
        <property type="term" value="P:secondary cell septum biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="424" mass="48102" checksum="FC9DB80283A36772" modified="2004-07-19" version="1">MSEEVWDGNQGTLSVYVSKAKDLPNLDKLDKQDVLLRLRIAHMTRESDTIIRAGQTPIFKYYEKFEITPELRPLMYVEIYSDRRKKAPILIGRCEVDLLNGIRADPKEGYCTWYELKKPNNDFAGTVFIELTFKPTYPTFRRDGESYNSRNQDKSMAARPIPPLPDDMSQFENEPESFRPNHYNSHFSSSSSSRTQSRFGGSESDYLHASAVRQVTPAIVDDNHHRVAQRFATSDNYGNENGPANFMSSVGTSSTVTTQDSSTTTITNNSDTKFHFANLRKLKEKINIFKNPNNSEEPETKNSNVDIEALQKAIGINNDAQSDDVSSTESFHERYQASRDISKSSSRGHNDALFKYSGGQNNEPPLPPLPKSPSRSPTRDRSPHRTPHSHHYHQHQEMVSPKLPPLPTSRNNSTSPTRRRPPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPB7</accession>
    <name>Q6FPB7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0J05082g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPB7"/>
    <dbReference type="FunCoup" id="Q6FPB7">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPB7"/>
    <dbReference type="KEGG" id="cgr:2889498"/>
    <dbReference type="CGD" id="CAL0133416">
        <property type="gene designation" value="CAGL0J05082g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05082g"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010228_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FPB7"/>
    <dbReference type="OMA" id="MICYFIV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="634"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="154"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0133416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="653" mass="73843" checksum="A7BB98C6B78808B1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPH7</accession>
    <name>Q6FPH7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sporulation-specific protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0J03740g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPH7"/>
    <dbReference type="FunCoup" id="Q6FPH7">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPH7"/>
    <dbReference type="KEGG" id="cgr:2889687"/>
    <dbReference type="CGD" id="CAL0133602">
        <property type="gene designation" value="CAGL0J03740g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03740g"/>
    <dbReference type="eggNOG" id="ENOG502RYS8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_715927_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPH7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0133602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41845" checksum="C35D610F350B5BB9" modified="2004-07-19" version="1">MDLSNHWARNFSGKLHNIHNGPTLSSIFGLDANYKQDVNISNVHVAEVKPFSIRRLAKTLILGSPIESVALNKDNTGKIKKRGAIVLSSYGSCADLKRPKINSADKICRSRTDDNLQKALLGLIQDMSSEDAIELCRNVSLFQKCNKFGNSSILSLGSDTKDITDIVFDNIPANIGLESIVYQLQGGPIAKIQAVPHESNVDQLKKLHVKFTTSKAASDFMKLGTRNMFKVNGVYLRPKWVQFCETKTDKWYQDLIKQNTSKNVCRCIILKRYPTKNNMRYIQSTKQPPLENIDVNAIRRDFENYGNILDITPVISRKLCISIVYYDIFSAMKAMMSYEDNTSFLHENYYGKWAIWYGKDISDRPVIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPJ0</accession>
    <name>Q6FPJ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone deacetylase</fullName>
            <ecNumber evidence="10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HDA1</name>
        <name evidence="14 15" type="ordered locus">CAGL0J03454g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="10"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447854.1">
        <property type="nucleotide sequence ID" value="XM_447854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPJ0"/>
    <dbReference type="FunCoup" id="Q6FPJ0">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPJ0"/>
    <dbReference type="ESTHER" id="canga-q6fpj0">
        <property type="family name" value="Arb2_domain"/>
    </dbReference>
    <dbReference type="GeneID" id="2889695"/>
    <dbReference type="KEGG" id="cgr:2889695"/>
    <dbReference type="CGD" id="CAL0133390">
        <property type="gene designation" value="HDA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03454g"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FPJ0"/>
    <dbReference type="OMA" id="CFVSPAC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990342">
        <property type="term" value="C:heterochromatin island"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070824">
        <property type="term" value="C:SHREC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140720">
        <property type="term" value="C:subtelomeric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902794">
        <property type="term" value="P:siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11600">
        <property type="entry name" value="HDAC_Clr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="12">
        <location>
            <begin position="70"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="13">
        <location>
            <begin position="443"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
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                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
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                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
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                <person name="Fabre E."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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</entry>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        </subcellularLocation>
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    </feature>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPY3"/>
    <dbReference type="FunCoup" id="Q6FPY3">
        <property type="interactions" value="522"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPY3"/>
    <dbReference type="KEGG" id="cgr:2889350"/>
    <dbReference type="CGD" id="CAL0130095">
        <property type="gene designation" value="CAGL0I10835g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I10835g"/>
    <dbReference type="eggNOG" id="KOG0072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_9_3_1"/>
    <dbReference type="InParanoid" id="Q6FPY3"/>
    <dbReference type="OMA" id="VRWSKDQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000510">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="127"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0130095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20537" checksum="038E5DA9705678EB" modified="2004-07-19" version="1">MGNFFSSMFDRLWGINKELRILILGLDGAGKTTILYRLQIGEVVTTKPTIGFNVETLTYKNLKLNVWDLGGQTSIRPYWRCYYADTAAVIFVVDSTDKDRMSTASKELHLMLQEEELQDAALLVFANKQDQPGALTASEVSKELNLVELKDRSWSIVASSAIKGEGITEGLDWLIDVIKDEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQA2</accession>
    <name>Q6FQA2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0I07887g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447592.1">
        <property type="nucleotide sequence ID" value="XM_447592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQA2"/>
    <dbReference type="KEGG" id="cgr:2889232"/>
    <dbReference type="CGD" id="CAL0132064">
        <property type="gene designation" value="CAGL0I07887g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07887g"/>
    <dbReference type="HOGENOM" id="CLU_723600_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQA2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="382" mass="43505" checksum="760DE041143C24CE" modified="2004-07-19" version="1">MGITIKTVNGDQVNEIKFDDCSYALKVFPLLTVLKYKIKDLYKEADVVCYYDGQSKLIQNERELSFPDGSTLIITFKRQVATNYVSTDDLDAQEYEIVSEKEDNAQKSVNVPVVVLDAIRKQVDKMDTFLKKVASEQHVNEEKYCKMELPKLIDAEEANDVCDPKEKALEISHCFEVYKRYKTLYYETKGQQINFSFEDYLDYILKNTDHQPIKVCSQAFVHLSQDYDTVTIDLVTTPGEFPTNHQLSVSTSNSNLFTINLSGFFPNTGGTKKFRYFPVTEDIKSKPLSVAISDKTTGRITMKGKSEGNSLPKLIRLSTVVDKIESSIDLDSIQEQTSKLYDEILKYETANKETSIISEDESAIKTESANWEEYDFLSDSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQA8</accession>
    <name>Q6FQA8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HAL9</name>
        <name evidence="8 9" type="ordered locus">CAGL0I07755g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
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        <source>
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</entry>
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    <accession>Q6FQG7</accession>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
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                <person name="Fabre E."/>
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                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
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                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447303.1">
        <property type="nucleotide sequence ID" value="XM_447303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR41"/>
    <dbReference type="FunCoup" id="Q6FR41">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR41"/>
    <dbReference type="GeneID" id="2889331"/>
    <dbReference type="KEGG" id="cgr:2889331"/>
    <dbReference type="CGD" id="CAL0132470">
        <property type="gene designation" value="GRE3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01122g"/>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR41"/>
    <dbReference type="OMA" id="VHWPSEG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032866">
        <property type="term" value="F:D-xylose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019568">
        <property type="term" value="P:arabinose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019388">
        <property type="term" value="P:galactose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0132470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="326" mass="37199" checksum="4819449F712D6110" modified="2004-07-19" version="1">MSSVVTLNNGLKMPLVGLGCWKIPNDVCAQQVYDAIKIGYRLFDGAEDYGNEKEVGQGIRKAIDEGVVKREDVFVVSKLWNSFHHPDHVKMALKRTLSDMGLDYLDLFYIHFPIAFKYVPFEEKYPPGFYTGKEDEKNGHITEAHVPIIDTYRALEQCVEEGLIKSIGISNFSGSLVQDLLRQCKIKPVALQVEHHPYLTQEHLVEYCKDNGIQVVAYSSFGPQSYIELNHPLAKNTPNLFHHDTIKQIANNHNVATSQVLLRWATQRGIAIIPKSSKKERLQDNLMIDEKLTLTHKELEAISKLNKNLRLNDPWDWLDGKFPIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR77</accession>
    <name>Q6FR77_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A diphosphatase SCS3</fullName>
            <ecNumber evidence="8">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">FIT family protein SCS3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SCS3</name>
        <name evidence="8" type="synonym">FIT2B</name>
        <name evidence="10 11" type="ordered locus">CAGL0I00330g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447267.1">
        <property type="nucleotide sequence ID" value="XM_447267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR77"/>
    <dbReference type="FunCoup" id="Q6FR77">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR77"/>
    <dbReference type="GeneID" id="2889313"/>
    <dbReference type="KEGG" id="cgr:2889313"/>
    <dbReference type="CGD" id="CAL0129861">
        <property type="gene designation" value="CAGL0I00330g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00330g"/>
    <dbReference type="eggNOG" id="KOG3750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048143_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FR77"/>
    <dbReference type="OMA" id="FIIWDNP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03231">
        <property type="entry name" value="SCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046400">
        <property type="entry name" value="SCS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0129861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="371" mass="43155" checksum="4D5CB3AF60A1AADE" modified="2004-07-19" version="1">MQTESVYRWVLLGICPTILILGNIIYMAYLDGPIAVNKDGFVNRILVKRGWFWTTVIGWLCILRYDAKRQWKSSLKRYLILTLWWYVFTQGILWFDIPPIMDLIFKYSGGSCNFDIYDSDGNVNLKFQDSWRRRIKSWRMIYDKVKDYQKNGKNPLAVDSKLMDFVTGSIEKAIEHYSYHIKSNIMIKEISRLLSDLNITYSTEQINDFIKNFISNTTVGNSSGANSTLDNSFACRLNGGYWQGGHDPSGHIFLLTLMILFLVGESKQFIVGAVMRVVDTRKYVMDKIKKICNEPMANASVYERRVRKLMRCLSFSASYILWENPVILLLLLLAIWVWNFVITVIVFHTLTEQLSGLFFAYVVGALLYYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRP6</accession>
    <name>Q6FRP6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0H06941g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRP6"/>
    <dbReference type="FunCoup" id="Q6FRP6">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRP6"/>
    <dbReference type="KEGG" id="cgr:2888629"/>
    <dbReference type="CGD" id="CAL0130054">
        <property type="gene designation" value="CAGL0H06941g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06941g"/>
    <dbReference type="eggNOG" id="KOG2319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007625_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FRP6"/>
    <dbReference type="OMA" id="DVCIAKK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036010">
        <property type="term" value="P:protein localization to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14369">
        <property type="entry name" value="CUE_VPS9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041545">
        <property type="entry name" value="DUF5601"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041804">
        <property type="entry name" value="Vps9_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18151">
        <property type="entry name" value="DUF5601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="179"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="411"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0130054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="52726" checksum="D2CE84001355D588" modified="2004-07-19" version="1">MESSHIREPKGQASDRDMNSNKTSQASEELQSNFKPELNEQLESHNQVVNALQSPEHEEEDVNETYYNFQLFLDQIQDARCAPLIKYTRSFLRNFVTQRAIWSATEQDKLIKDFKTFIYSKYKDFKPFSDLNKTELRNAEEGMEKLLTGKLYHHLFSPLLAERAKAAGIEADKEHLDDIEKDKMFIKKVAEFKFIEPTNLDISFQNVKRVKKFTSFASIELNKMNNFKAPRDKMVCILNASKILFGLMKHSEETGADCFVPLLIYTLLSGKIENLVSNINFIERFRYSSLFRGEEAYYLSSLQAASNFILKLDKKSLTIENEKDFDTKYEQNIENVKQDQLQKEKLLKETKQEESSNMLDDVSNMVMNKLNEFFIQDEPQKEKKKEVHHKANSKNEDGEVASMIKQLEAKEHQETVETLTSMFPDLDVEIIEDVCIAKKHRIGPCVDVLLTLSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-12" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRT2</accession>
    <name>CCR4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4</fullName>
            <ecNumber>3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Carbon catabolite repressor protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Cytoplasmic deadenylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Glucose-repressible alcohol dehydrogenase transcriptional effector</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CCR4</name>
        <name type="ordered locus">CAGL0H06149g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447062.1">
        <property type="nucleotide sequence ID" value="XM_447062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRT2"/>
    <dbReference type="SMR" id="Q6FRT2"/>
    <dbReference type="FunCoup" id="Q6FRT2">
        <property type="interactions" value="508"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRT2"/>
    <dbReference type="EnsemblFungi" id="CAGL0H06149g-T">
        <property type="protein sequence ID" value="CAGL0H06149g-T-p1"/>
        <property type="gene ID" value="CAGL0H06149g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888713"/>
    <dbReference type="KEGG" id="cgr:2888713"/>
    <dbReference type="CGD" id="CAL0131866">
        <property type="gene designation" value="CAGL0H06149g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06149g"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016428_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FRT2"/>
    <dbReference type="OMA" id="LWHAIDF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000037">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000598">
        <property type="entry name" value="Glucose-repressible alcohol dehydrogenase transcriptional effector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF100">
        <property type="entry name" value="POLY(A)-SPECIFIC RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0433">Leucine-rich repeat</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000290608" description="CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4">
        <location>
            <begin position="1"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 2">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 3">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="LRR 4">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O95551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P31384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="873" mass="98578" checksum="796DB965C95E673D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRX2</accession>
    <name>Q6FRX2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H05203g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRX2"/>
    <dbReference type="FunCoup" id="Q6FRX2">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRX2"/>
    <dbReference type="KEGG" id="cgr:2888892"/>
    <dbReference type="CGD" id="CAL0132034">
        <property type="gene designation" value="CAGL0H05203g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05203g"/>
    <dbReference type="eggNOG" id="ENOG502QSRB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_598506_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRX2"/>
    <dbReference type="OMA" id="PRIECQL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053060">
        <property type="entry name" value="Cytokinesis_Signaling_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419">
        <property type="entry name" value="ARRESTIN FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36419:SF1">
        <property type="entry name" value="RHO1 GEF LOCALIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="54422" checksum="DD5CD7FA75B75A8E" modified="2004-07-19" version="1">MTVPIISLMPSYNSMIRGCPGISDTLPRIECQLRVRSNNGSEFRIAKIEVILKSVETVFPQSHVSYSFTPIGKSKSKPRKNESISYHYKKSFYLANDEKCKAAKNKNTQRISKPLIGVDFPLTISLPADINDTNFNSRFGTCVTYLECNLLYYDLEKVGPSFDSVPPELKNFITTVNVERYTNLPLKKLFPAIEKNFYSPDKKLKAKVYVENPCITTDDLLKIKLKVMPNQHSSSTAPEYENSVLFKKKLKVKSVTFQTKEIFQCHSETYESKEYVLDTETKNYNEIITMNGFETANDIHICTKDVLFKEFENTMLEPELLYKLPKQPEGNMTNRNVPTKLLQNKVDAIPFRYHCSISTNGKYYSIGHAIDIKIKIGSGKDFEFSIPITISQWLKSHTKYIQQAIIQEREIASHAKRFYSGYGGLQKHSNGMIEYPTLPPIIYDSREHNNSKNFHIFQLTSGNGKSQLKKLPIID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS98</accession>
    <name>CUE1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Coupling of ubiquitin conjugation to ER degradation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CUE1</name>
        <name type="ordered locus">CAGL0H02321g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with UBC7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CUE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446896.1">
        <property type="nucleotide sequence ID" value="XM_446896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS98"/>
    <dbReference type="SMR" id="Q6FS98"/>
    <dbReference type="FunCoup" id="Q6FS98">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS98"/>
    <dbReference type="EnsemblFungi" id="CAGL0H02321g-T">
        <property type="protein sequence ID" value="CAGL0H02321g-T-p1"/>
        <property type="gene ID" value="CAGL0H02321g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888868"/>
    <dbReference type="KEGG" id="cgr:2888868"/>
    <dbReference type="CGD" id="CAL0131762">
        <property type="gene designation" value="CAGL0H02321g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H02321g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02321g"/>
    <dbReference type="eggNOG" id="ENOG502S35Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115919_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS98"/>
    <dbReference type="OMA" id="TVNRFME"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990389">
        <property type="term" value="C:CUE1-UBC7 ubiquitin-conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000837">
        <property type="term" value="C:Doa10p ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097027">
        <property type="term" value="F:ubiquitin-protein transferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097051">
        <property type="term" value="P:establishment of protein localization to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041158">
        <property type="entry name" value="Cue1_U7BR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18499">
        <property type="entry name" value="Cue1_U7BR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000280671" description="Coupling of ubiquitin conjugation to ER degradation protein 1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="70"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="203" mass="22968" checksum="94A3637A32224A3F" modified="2004-07-19" version="1">MEHSAAVVVATLILGIFVVKWFAAPKEHPSAQRLPNTQLPSSSNNQQRTAGSSNGRGSQRRVSSTSRRNITPEMIETVRNVIPALHPEQIRYDLESTGSVEQTMERYFNGESFPFPPGYTPARESSANGQHNNIDEPSDIRKRSNIRPDNLLSKFNVDMSVDMSDMSIKELEIDERKKLLVWEARKNMEKRLETDTELASLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSH2</accession>
    <name>Q6FSH2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein ILM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H00550g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSH2"/>
    <dbReference type="FunCoup" id="Q6FSH2">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888707"/>
    <dbReference type="CGD" id="CAL0130599">
        <property type="gene designation" value="CAGL0H00550g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00550g"/>
    <dbReference type="eggNOG" id="ENOG502RZTE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117796_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FSH2"/>
    <dbReference type="OMA" id="EVWLNFI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018815">
        <property type="entry name" value="Incr_loss_mito_DNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029:SF1">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10311">
        <property type="entry name" value="Ilm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="19129" checksum="ABF08A8D9E1B033D" modified="2004-07-19" version="1">MGILSAQNLILLRSALLLTIAFFCIKNVNSILQNSFFLVLSQAMELPALSMSQYSGQLGMFSMLFFFAALNDLVPLMEDNKTYFRSIVPVRLTVFFIIGAIAYLWTENLYFHNNAVFIYCFIEIWINFLLLNAVREERNEEFKREHRFMNDDLIEEPAPFEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSH9</accession>
    <name>Q6FSH9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0H00396g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSH9"/>
    <dbReference type="FunCoup" id="Q6FSH9">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSH9"/>
    <dbReference type="KEGG" id="cgr:2888779"/>
    <dbReference type="CGD" id="CAL0131836">
        <property type="gene designation" value="CAGL0H00396g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00396g"/>
    <dbReference type="eggNOG" id="ENOG502QPVP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015609_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSH9"/>
    <dbReference type="OMA" id="MQIGLHQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001278">
        <property type="term" value="P:positive regulation of L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000003">
        <property type="entry name" value="C6 transcription factor (Leu3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="57"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="694"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="755"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="694"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
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            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="780"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0131836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="940" mass="106329" checksum="7EA2079F5CE5004F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSI8</accession>
    <name>Q6FSI8_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAGL0H00110g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSI8"/>
    <dbReference type="STRING" id="284593.Q6FSI8"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00110g"/>
    <dbReference type="HOGENOM" id="CLU_756489_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSI8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049451">
        <property type="entry name" value="AWP2-like_YTTT_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20646">
        <property type="entry name" value="Hpf1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="366" mass="38479" checksum="22E9D9B6F4E42036" modified="2004-07-19" version="1">MVTRSQLLYLNVTTSNDIGQTVTNTVTVMSYDQVGDGVYTSAPGYSQAPVTTTTVSADTATATVVISHFPSIGVDGVTRTGTTTLSTVSVGGETGYTTSVDRGNGSIETDVISHITTTDSNGNPTTITTTITNAQSASNSKANVGSDYTTTVVSDGHTLTEIVSHSTGTDEHGHTIVSTVTETLGVQSHGNTVSSTVPVSTVSGAGSNASGAAGVGGIVNSQKPQSQNVADQGSGNEKPTQASAQPVVVALALALALALGQFTNRQAVMYHLDPHLFRVQRVLCLQSVVFIVAKHHTLYLPKPNNKDKDKHHHHVNSLPRLFYHLLVPLLTTSAVDSAARKQHLSYRVRVLRLELLLPVLYSPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSK0</accession>
    <name>Q6FSK0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycogen debranching enzyme</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
            <ecNumber evidence="6">3.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glycogen debrancher</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">GDB1</name>
        <name evidence="21 22" type="ordered locus">CAGL0G09977g</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2016" name="Nat. Commun." volume="7" first="11229" last="11229">
            <title>Crystal structure of glycogen debranching enzyme and insights into its catalysis and disease-causing mutations.</title>
            <authorList>
                <person name="Zhai L."/>
                <person name="Feng L."/>
                <person name="Xia L."/>
                <person name="Yin H."/>
                <person name="Xiang S."/>
            </authorList>
            <dbReference type="PubMed" id="27088557"/>
            <dbReference type="DOI" id="10.1038/ncomms11229"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS)</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <reference evidence="26 27 28" key="3">
        <citation type="journal article" date="2021" name="Acta Crystallogr. F Struct. Biol. Commun." volume="77" first="420" last="426">
            <title>Crystal structures of glycogen-debranching enzyme mutants in complex with oligosaccharides.</title>
            <authorList>
                <person name="Shen M."/>
                <person name="Gong X."/>
                <person name="Xiang S."/>
            </authorList>
            <dbReference type="PubMed" id="34726181"/>
            <dbReference type="DOI" id="10.1107/s2053230x21010918"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS)</scope>
    </reference>
    <reference evidence="29" key="4">
        <citation type="submission" date="2021-04" db="PDB data bank">
            <title>Crystal Structure of the Candida Glabrata Glycogen Debranching Enzyme (W958A).</title>
            <authorList>
                <person name="Shen M."/>
                <person name="Xiang S."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of (1-&gt;6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.</text>
            <dbReference type="EC" id="3.2.1.33"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycogen debranching enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EC" id="3.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446794.1">
        <property type="nucleotide sequence ID" value="XM_446794.1"/>
    </dbReference>
    <dbReference type="PDB" id="5D06">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A/B=1-1528"/>
    </dbReference>
    <dbReference type="PDB" id="5D0F">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="A/B=1-1528"/>
    </dbReference>
    <dbReference type="PDB" id="7EIM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A/B=1-1528"/>
    </dbReference>
    <dbReference type="PDB" id="7EJP">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A/B=1-1528"/>
    </dbReference>
    <dbReference type="PDB" id="7EJT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.20 A"/>
        <property type="chains" value="A/B=1-1528"/>
    </dbReference>
    <dbReference type="PDB" id="7EKU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A/B=1-1528"/>
    </dbReference>
    <dbReference type="PDB" id="7EKW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.10 A"/>
        <property type="chains" value="A/B=1-1528"/>
    </dbReference>
    <dbReference type="PDB" id="7EKX">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="A/B=1-1528"/>
    </dbReference>
    <dbReference type="PDBsum" id="5D06"/>
    <dbReference type="PDBsum" id="5D0F"/>
    <dbReference type="SMR" id="Q6FSK0"/>
    <dbReference type="FunCoup" id="Q6FSK0">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSK0"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="CAZy" id="GH133">
        <property type="family name" value="Glycoside Hydrolase Family 133"/>
    </dbReference>
    <dbReference type="GeneID" id="2888155"/>
    <dbReference type="KEGG" id="cgr:2888155"/>
    <dbReference type="CGD" id="CAL0129165">
        <property type="gene designation" value="GDB1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09977g"/>
    <dbReference type="eggNOG" id="KOG3625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001517_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FSK0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11327">
        <property type="entry name" value="AmyAc_Glg_debranch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000070">
        <property type="entry name" value="GDB1p Glycogen debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000039">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000242">
        <property type="entry name" value="Glycogen debranching enzyme Gdb1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029436">
        <property type="entry name" value="AGL_euk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006421">
        <property type="entry name" value="Glycogen_debranch_met"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01531">
        <property type="entry name" value="glyc_debranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14699">
        <property type="entry name" value="hGDE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="24 25 26" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Eukaryotic glycogen debranching enzyme N-terminal" evidence="18">
        <location>
            <begin position="49"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="19">
        <location>
            <begin position="139"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="20">
        <location>
            <begin position="727"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="17">
        <location>
            <begin position="1038"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0129165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG59721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="24">
        <source>
            <dbReference type="PDB" id="5D06"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="25">
        <source>
            <dbReference type="PDB" id="5D0F"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="26">
        <source>
            <dbReference type="PDB" id="7EIM"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="27">
        <source>
            <dbReference type="PDB" id="7EJP"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="28">
        <source>
            <dbReference type="PDB" id="7EJT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="29">
        <source>
            <dbReference type="PDB" id="7EKU"/>
        </source>
    </evidence>
    <sequence length="1528" mass="174266" checksum="54069E4A89E9433D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-02-28" modified="2025-06-18" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSQ7</accession>
    <name>QDR2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multidrug transporter QDR2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Clotrimazole exporter QDR2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Drug:H(+) antiporter QDR2</fullName>
            <shortName evidence="7">DHA QDR2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">QDR2</name>
        <name type="ordered locus">CAGL0G08624g</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="Antimicrob. Agents Chemother." volume="57" first="3159" last="3167">
            <title>Candida glabrata drug:H+ antiporter CgQdr2 confers imidazole drug resistance, being activated by transcription factor CgPdr1.</title>
            <authorList>
                <person name="Costa C."/>
                <person name="Pires C."/>
                <person name="Cabrito T.R."/>
                <person name="Renaudin A."/>
                <person name="Ohno M."/>
                <person name="Chibana H."/>
                <person name="Sa-Correia I."/>
                <person name="Teixeira M.C."/>
            </authorList>
            <dbReference type="PubMed" id="23629708"/>
            <dbReference type="DOI" id="10.1128/AAC.00811-12"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="526" last="526">
            <title>Clotrimazole drug resistance in Candida glabrata clinical isolates correlates with increased expression of the drug:H(+) antiporters CgAqr1, CgTpo1_1, CgTpo3, and CgQdr2.</title>
            <authorList>
                <person name="Costa C."/>
                <person name="Ribeiro J."/>
                <person name="Miranda I.M."/>
                <person name="Silva-Dias A."/>
                <person name="Cavalheiro M."/>
                <person name="Costa-de-Oliveira S."/>
                <person name="Rodrigues A.G."/>
                <person name="Teixeira M.C."/>
            </authorList>
            <dbReference type="PubMed" id="27148215"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.00526"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Multidrug resistance transporter involved in resistance to the antifungal drugs miconazole, tioconazole, clotrimazole, and ketoconazole; as well as to quinidine (PubMed:23629708, PubMed:27148215). Decreases the intracellular accumulation of clotrimazole in and plays a role in the extrusion of this antifungal from preloaded cells (PubMed:23629708, PubMed:27148215).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is up-regulated by clotrimazole and quinidine (PubMed:23629708). Expression is regulated by the pleiotropic drug resistance transcription factor PDR1 (PubMed:23629708).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to intracellular accumulation of clotrimazole (PubMed:23629708).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446737.1">
        <property type="nucleotide sequence ID" value="XM_446737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSQ7"/>
    <dbReference type="FunCoup" id="Q6FSQ7">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSQ7"/>
    <dbReference type="TCDB" id="2.A.1.2.115">
        <property type="family name" value="the major facilitator superfamily (mfs)"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q6FSQ7">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0G08624g-T">
        <property type="protein sequence ID" value="CAGL0G08624g-T-p1"/>
        <property type="gene ID" value="CAGL0G08624g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888131"/>
    <dbReference type="KEGG" id="cgr:2888131"/>
    <dbReference type="CGD" id="CAL0130703">
        <property type="gene designation" value="QDR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08624g"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_4_1"/>
    <dbReference type="InParanoid" id="Q6FSQ7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000443413" description="Multidrug transporter QDR2">
        <location>
            <begin position="1"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23629708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="27148215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="23629708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="27148215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="583" mass="64364" checksum="F51C5A8B0197D6C4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSS4</accession>
    <name>ERFB_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Palmitoyltransferase ERF2</fullName>
            <ecNumber evidence="2">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>DHHC cysteine-rich domain-containing protein ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Ras protein acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ERF2</name>
        <name type="ordered locus">CAGL0G08217g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with ERF4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Autopalmitoylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="2"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446720.1">
        <property type="nucleotide sequence ID" value="XM_446720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSS4"/>
    <dbReference type="SMR" id="Q6FSS4"/>
    <dbReference type="FunCoup" id="Q6FSS4">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSS4"/>
    <dbReference type="EnsemblFungi" id="CAGL0G08217g-T">
        <property type="protein sequence ID" value="CAGL0G08217g-T-p1"/>
        <property type="gene ID" value="CAGL0G08217g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888209"/>
    <dbReference type="KEGG" id="cgr:2888209"/>
    <dbReference type="CGD" id="CAL0130306">
        <property type="gene designation" value="CAGL0G08217g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08217g"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047581_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSS4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000212940" description="Palmitoyltransferase ERF2">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="4">
        <location>
            <begin position="84"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="4">
        <location>
            <begin position="112"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="4">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="4">
        <location>
            <begin position="263"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="5">
        <location>
            <begin position="158"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q06551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q8VDZ4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9UIJ5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="326" mass="37644" checksum="6352F4C324610E04" modified="2004-07-19" version="1">MKGNPSTHEVIGTMSTRRFYRWLITIDGDTEINYRNYEELPSRSNYIFFFGGRLRAVKTARPFSLVVLFLILSPMVLFSVFEAHRLWHTRYGYKALVVLFYYAWAWSLLSFTKTATSDPGVLPRNIHMHKDTPQEYFNNVTLPYGAGGSAGNASVTLKYCHTCKIWRPPRASHCSVCECCVLTHDHHCIWVNNCVGQRNYRYFLAFLLSSTLACALLIANCALHLHRALHEGIRVSHRPLPVAVLLCVYAAVLCVYPVILLGYHVAMSGTQQTTREYLRSIGFRNPVMHRIRRRRDNPYAEHGFLRNMLDLMAEPRGPRSCNYRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT65</accession>
    <name>Q6FT65_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS15 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0G05027g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT65"/>
    <dbReference type="FunCoup" id="Q6FT65">
        <property type="interactions" value="1047"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT65"/>
    <dbReference type="KEGG" id="cgr:2887982"/>
    <dbReference type="CGD" id="CAL0130665">
        <property type="gene designation" value="CAGL0G05027g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05027g"/>
    <dbReference type="eggNOG" id="KOG0400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090139_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FT65"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0130665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="151" mass="17061" checksum="5594AFD07342ADF7" modified="2004-07-19" version="1">MGRMHSSGKGISSSAIPYSRNAPAWFKTSTESVIEQIIKYARKGLTPSQIGVLLRDAHGVTQARVITGNKIMRILKSNGLAPEIPEDLYYLIKKAVSVRKHLERNRKDKDAKFRLILIESRIHRLARYYRTVAVLPPNWKYESATASALVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT69</accession>
    <name>Q6FT69_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G04939g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT69"/>
    <dbReference type="FunCoup" id="Q6FT69">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT69"/>
    <dbReference type="KEGG" id="cgr:2888289"/>
    <dbReference type="CGD" id="CAL0137671">
        <property type="gene designation" value="CAGL0G04939g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04939g"/>
    <dbReference type="eggNOG" id="ENOG502QU21">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477498_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT69"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="589" mass="69284" checksum="EA794399880C1075" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTM1</accession>
    <name>Q6FTM1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G01408g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446423.1">
        <property type="nucleotide sequence ID" value="XM_446423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTM1"/>
    <dbReference type="KEGG" id="cgr:2888187"/>
    <dbReference type="CGD" id="CAL0130420">
        <property type="gene designation" value="CAGL0G01408g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01408g"/>
    <dbReference type="HOGENOM" id="CLU_1895922_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTM1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="134" mass="15683" checksum="9337DE5E2A5D9CC2" modified="2004-07-19" version="1">MKWFKQAKLKFKIKKKSKRVSKELVQIPASFNTRQALVNADDQYSHKVFMDSKQYILSKYLTLFTVLFCALAICVTLVCAPRIIRIYYSNKVTYTKWALLLSLISPQQQQLPLLSGTFSLGTIFSLYKWLVWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTN1</accession>
    <name>Q6FTN1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ORM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0G01188g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTN1"/>
    <dbReference type="STRING" id="284593.Q6FTN1"/>
    <dbReference type="KEGG" id="cgr:2888162"/>
    <dbReference type="CGD" id="CAL0130771">
        <property type="gene designation" value="CAGL0G01188g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01188g"/>
    <dbReference type="eggNOG" id="KOG3319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072117_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FTN1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090156">
        <property type="term" value="P:intracellular sphingolipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090155">
        <property type="term" value="P:negative regulation of sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0130771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24887" checksum="88AEB1F4A814FB83" modified="2004-07-19" version="1">MSVPPLTKTISQSSFAESLRDLSSDEDLINKRIGSPNRDHRRRRSSSILSHVEPETFEDENDQHILTNMNATWMDQPGAWIIHVVIILLLAGMYKVMPGMSTKNAWSLTNTTYVIGSYVMFHWIKGTPFEFNGGAYDNLTMWEQIDGETLFTPTRKYLISVPIVLFLIVTHYSRGSHFFSKDFIWNCCVTFFGAILPKLPITHRLRLSIPGFTPAQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU13</accession>
    <name>Q6FU13_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAGL0F07183g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU13"/>
    <dbReference type="FunCoup" id="Q6FU13">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU13"/>
    <dbReference type="eggNOG" id="KOG1234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_9_0_1"/>
    <dbReference type="InParanoid" id="Q6FU13"/>
    <dbReference type="OMA" id="PEYYVPR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="5">
        <location>
            <begin position="68"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="414" mass="47262" checksum="9B8AA7ACEE33DF2F" modified="2004-07-19" version="1">MNAAAEGLSQVSKGQSPNWKSLILSESNIDRITKKFSQMRGAALKIGQMMSFQDEKILPRELYEILSRVQNSANYMPRRQLEKVMTKELGDNWEAKFKSFDKIPIAAASIGQVHNGELLDGTKIVVKVQYPGVKDSIDSDLNNLLLLLTASRLLPKGLFLDKTVANARTELKWECDYIREAKALQRFELLLKDDPVFVVPHVYEEFTTENVLTMSRMEGTEIMNLKNESNSQEIRNFISENIMRLCLEEIAVFEFMQTDPNWANFLYNAKTNKIELLDFGASRPFPSDFIKKYRKLLTYATQENRAGAYEMSKELGYLTGLESQSMKDAHVDSVMTLGEPFRGSVEDVFDFANQTVSDRIRGNIGLMVNERLCPPPEETYSLHRKFSGIFLLCARMEASVHCAKLFSKYFALKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUA3</accession>
    <name>Q6FUA3_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0F05049g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUA3"/>
    <dbReference type="FunCoup" id="Q6FUA3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUA3"/>
    <dbReference type="KEGG" id="cgr:2887894"/>
    <dbReference type="CGD" id="CAL0131046">
        <property type="gene designation" value="CAGL0F05049g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05049g"/>
    <dbReference type="eggNOG" id="ENOG502RBZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062868_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUA3"/>
    <dbReference type="OMA" id="PQDQHDI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000214">
        <property type="term" value="P:regulation of L-proline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF12">
        <property type="entry name" value="MOZ PROTEIN REPRESENTS A CHROMATIN-ASSOCIATED ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0131046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="293" mass="33608" checksum="56A0E8D491F921AB" modified="2004-07-19" version="1">MRSALRESTKHIRTWRYTPRPKVIRAYHSTPLLQINSTQYLKEKVSNKLTNDETPLDFINKLPEQLISQGNGLSPTDAAHQVNTLEYYKRLKYEGGFNSEQSNAIIALLLEIIDDEFYKTYNTKFLRDMELNKQSHLFNSAETELKYAIQNSRDTQLNSQHLQMMILQRDLAILHDEINELIINLLNKDSKMDFNNQKLENTLLLKEVNLHLSGSTNKIITKLMGEVKSDIENLRWQTTRSGLVAILLLVLMVMGAVSLTKNKASEEKKEAPTRTVYDQSLSVASEEPPQAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUE6</accession>
    <name>Q6FUE6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TEC2</name>
        <name evidence="9 10" type="ordered locus">CAGL0F04081g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446148.1">
        <property type="nucleotide sequence ID" value="XM_446148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUE6"/>
    <dbReference type="STRING" id="284593.Q6FUE6"/>
    <dbReference type="KEGG" id="cgr:2887858"/>
    <dbReference type="CGD" id="CAL0129400">
        <property type="gene designation" value="TEC2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04081g"/>
    <dbReference type="eggNOG" id="KOG3841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444094_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUE6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="116"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="116"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0129400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="615" mass="68449" checksum="6100861B2FBCA956" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUG8</accession>
    <name>Q6FUG8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit</fullName>
            <ecNumber evidence="4">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0F03597g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="4"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUG8"/>
    <dbReference type="FunCoup" id="Q6FUG8">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUG8"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887616"/>
    <dbReference type="CGD" id="CAL0130936">
        <property type="gene designation" value="CAGL0F03597g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03597g"/>
    <dbReference type="eggNOG" id="KOG1111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_19_0_1"/>
    <dbReference type="InParanoid" id="Q6FUG8"/>
    <dbReference type="OMA" id="SHFWMSG"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="12">
        <location>
            <begin position="42"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="11">
        <location>
            <begin position="194"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0130936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="454" mass="51642" checksum="AFA75E9B87DE85D2" modified="2004-07-19" version="1">MGYNIAMVCDFFYPQLGGVEFHIYHLAQNLLRLGHSVVIITHAYKDRAGIRYLTNGLKVYHVPFFVLYRETTFPTIFSTFPVVRNILIREQIQIVHSHGSVSTFAHETILHANSMGLKTLFTDHSLYGFDSMGSILVNKLLTFHLTCIDRVICVSNTCKENMVMRTDIEPDRVYVIPNAVVSKDFRPRSPQEERLKSNDRITIVVISRLFPNKGADLLVRIIPIICQEHSDVDFIVAGDGPKFIEVQQMIEKYRLESRVTLLGSVPHEKVRDVMCKGDIYLHASLTEAFGTVLVEAASCGLLIVTTMVGGIPEVLPEHMTVFAENTSVSSLIDATMKGIQLIKNKSVDTKQIARDVSVMYDWMDVAKRTVSVYQGIFEDSSPTDKDWVKMVHRYYKRDGSWAHLLYVLCCIVSYLMVNILDFCYPREDIDLAIKWPRPQLNDDDGHVEITKKGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-02-08" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUM2</accession>
    <name>YFH7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent kinase YFH7</fullName>
            <ecNumber>2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">YFH7</name>
        <name type="ordered locus">CAGL0F02343g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent kinase that could be involved in endoplasmic reticulum membrane assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YFH7 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446072.1">
        <property type="nucleotide sequence ID" value="XM_446072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUM2"/>
    <dbReference type="SMR" id="Q6FUM2"/>
    <dbReference type="FunCoup" id="Q6FUM2">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUM2"/>
    <dbReference type="EnsemblFungi" id="CAGL0F02343g-T">
        <property type="protein sequence ID" value="CAGL0F02343g-T-p1"/>
        <property type="gene ID" value="CAGL0F02343g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887809"/>
    <dbReference type="KEGG" id="cgr:2887809"/>
    <dbReference type="CGD" id="CAL0131310">
        <property type="gene designation" value="CAGL0F02343g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02343g"/>
    <dbReference type="eggNOG" id="KOG2702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067202_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FUM2"/>
    <dbReference type="OMA" id="LYDQENW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000404213" description="ATP-dependent kinase YFH7">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="31"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="345" mass="39283" checksum="41707713EF8FD923" modified="2004-07-19" version="1">MVDVNRLKEEVIASYREICKENYRLLVFIVGPPGSGKSTIAEKLKDAINTSYLDYLKEIDRKTLRCENYNHINIDQFVQGIEGETISSALEDERHENFDSVENVDFICKKKRLKDGSYTITGRGGQLNAIKVRQPTSQEKNLEGNTTIAEVLPMDGFHLSRECLDHFSDPQWAHLRRGSSLTFDSNNFLKLCEIMAKTSRIFPSIGYDGDDFTAFDAISSSFDCSVPSVEVPGFDHSLKDPQPSQHTISFKSRIVIFEGLYLLYNKENWSKIYNIVSNSNAKLFYKILACEDQIESRVAKRHLKAGLVASIEDGKDKFRKNDLLNARDVEKNSISSEDIRLIRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUN4</accession>
    <name>Q6FUN4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0F02013g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUN4"/>
    <dbReference type="FunCoup" id="Q6FUN4">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUN4"/>
    <dbReference type="KEGG" id="cgr:2887910"/>
    <dbReference type="CGD" id="CAL0129527">
        <property type="gene designation" value="CAGL0F02013g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02013g"/>
    <dbReference type="eggNOG" id="ENOG502S4J9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091402_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUN4"/>
    <dbReference type="OMA" id="WRFVITG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="242" mass="26428" checksum="8AFD5A3F52D4FB20" modified="2004-07-19" version="1">MPQSKDDPPNVPSGWKAVFDDEYQTWFYVYLATKRSQWEEPEGTTWNKISKPPMPPPSYKSKEEYARGSVSPPHSARRAQPAPPPQTTYRSQPPAPVSPQPYYSPQVPQQQPMPMYPPQQPMPMPMYAPQQPVYGGAPMPQPVYQQAPVAQQKSSSGVGKKAFFGSLAGAGVGVLGAEAISHAFDHHHDQDTTVVENNYYDNGPGGYDNGYGGGGGYDNGYDQGYNDGFDDGNYDGGDGGDW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUS3</accession>
    <name>SIL1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Nucleotide exchange factor SIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SIL1</name>
        <name type="ordered locus">CAGL0F01089g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with KAR2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SIL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446021.1">
        <property type="nucleotide sequence ID" value="XM_446021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUS3"/>
    <dbReference type="SMR" id="Q6FUS3"/>
    <dbReference type="FunCoup" id="Q6FUS3">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUS3"/>
    <dbReference type="EnsemblFungi" id="CAGL0F01089g-T">
        <property type="protein sequence ID" value="CAGL0F01089g-T-p1"/>
        <property type="gene ID" value="CAGL0F01089g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887649"/>
    <dbReference type="KEGG" id="cgr:2887649"/>
    <dbReference type="CGD" id="CAL0129362">
        <property type="gene designation" value="CAGL0F01089g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01089g"/>
    <dbReference type="eggNOG" id="KOG2160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818876_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUS3"/>
    <dbReference type="OMA" id="EHLEDSH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031884">
        <property type="entry name" value="Sil1_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16782">
        <property type="entry name" value="SIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000223361" description="Nucleotide exchange factor SIL1">
        <location>
            <begin position="22"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Prevents secretion from ER" evidence="2">
        <location>
            <begin position="336"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="339" mass="38225" checksum="45FB1C2135123780" modified="2004-07-19" version="1" precursor="true">MVAKVWSRVILIFIATVMVFASSQQGDANKVNTASPPGANGIAYASVVAGGSNHVSAAGSVTGDGVQLPNAEVDIDWLEEHLEDSHDYEKGYDLVEQHFNKLLVGNNADASFKVRELASRLILGTLRNNPPVKRLIWDQHPLFVSQVFDLYIGNALKQGSGNPLKYPLLKRYLSILLELIPFNRDFRFEEDYKDILDKLYTESDVPSDIKIKVLELITLDYSNIKGASGWIDRITNVLTDSEMGLDELHKRTFFNAMHALKSEDPKLKLPTNFLNWLAQETKERAHNLKLAQAQADDNDLKVRDLEQEEFDQRLVDSRHSVFGNPMAARMKDPYIVDEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-03" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUV3</accession>
    <name>DOHH_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="1">DOHH</shortName>
            <ecNumber evidence="1">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">LIA1</name>
        <name type="ordered locus">CAGL0F00407g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="1"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445991.1">
        <property type="nucleotide sequence ID" value="XM_445991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUV3"/>
    <dbReference type="SMR" id="Q6FUV3"/>
    <dbReference type="FunCoup" id="Q6FUV3">
        <property type="interactions" value="972"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUV3"/>
    <dbReference type="EnsemblFungi" id="CAGL0F00407g-T">
        <property type="protein sequence ID" value="CAGL0F00407g-T-p1"/>
        <property type="gene ID" value="CAGL0F00407g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887799"/>
    <dbReference type="KEGG" id="cgr:2887799"/>
    <dbReference type="CGD" id="CAL0129185">
        <property type="gene designation" value="CAGL0F00407g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_F00407g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00407g"/>
    <dbReference type="eggNOG" id="KOG0567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053974_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUV3"/>
    <dbReference type="OMA" id="LQEPCSI"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000099">
        <property type="entry name" value="Deoxyhypusine hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0503">Monooxygenase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000283659" description="Deoxyhypusine hydroxylase">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT-like PBS-type 1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT-like PBS-type 2">
        <location>
            <begin position="203"/>
            <end position="229"/>
        </location>
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                <person name="Fischer G."/>
                <person name="Durrens P."/>
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                <person name="Lafontaine I."/>
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                <person name="Talla E."/>
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                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
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                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
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                <person name="Ozier-Kalogeropoulos O."/>
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            <title>Structural basis for promiscuity and specificity during Candida glabrata invasion of host epithelia.</title>
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        <citation type="journal article" date="2020" name="J. Biol. Chem." volume="295" first="12512" last="12524">
            <title>Functional reprogramming of &lt;i&gt;Candida glabrata&lt;/i&gt; epithelial adhesins: the role of conserved and variable structural motifs in ligand binding.</title>
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                <person name="Reithofer V."/>
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    <accession>Q6FUY2</accession>
    <name>Q6FUY2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0E06270g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUY2"/>
    <dbReference type="FunCoup" id="Q6FUY2">
        <property type="interactions" value="711"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUY2"/>
    <dbReference type="KEGG" id="cgr:2887349"/>
    <dbReference type="CGD" id="CAL0128584">
        <property type="gene designation" value="CAGL0E06270g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06270g"/>
    <dbReference type="eggNOG" id="KOG3214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105983_0_3_1"/>
    <dbReference type="InParanoid" id="Q6FUY2"/>
    <dbReference type="OMA" id="HEKSITC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0128584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="147" mass="16320" checksum="7CEBF615DE899F36" modified="2004-07-19" version="1">MGKRKKSSRGPVKRVVQKLDTSFNCLFCNHEKSVSCTLDKKNCIGHLSCKICGQSFQTRINSLSQPVDVYSDWFDAVEEVNSGRGSDSEHDNDDENSDSDYESDSDEAAAPQDSDEQEVDSDEDERIGASKRGRGALVDSDEEEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUZ1</accession>
    <name>Q6FUZ1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0E06072g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445953.1">
        <property type="nucleotide sequence ID" value="XM_445953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUZ1"/>
    <dbReference type="FunCoup" id="Q6FUZ1">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887394"/>
    <dbReference type="CGD" id="CAL0128670">
        <property type="gene designation" value="CAGL0E06072g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06072g"/>
    <dbReference type="HOGENOM" id="CLU_1517678_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUZ1"/>
    <dbReference type="OMA" id="YRNNICK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="177" mass="19652" checksum="A8ED7217B683ED7C" modified="2004-07-19" version="1">MQSLDNEYRVRGFVSPSSTPPGTGMMNSRTVSSSSSVSSDSSNPSSAMMLNFYKGSVEDPASILYRNNICKSFEDDLFFCPRSLLSPQEQKKCQEIDSLFTYQQHASSPLLPATLHELSNVPMSPTSSPTAFNTNPMMNFNNMTNKRTASTVHRPMSPRSAKFNPYKSQSFNPSDIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV08</accession>
    <name>Q6FV08_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0E05698g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV08"/>
    <dbReference type="FunCoup" id="Q6FV08">
        <property type="interactions" value="353"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV08"/>
    <dbReference type="KEGG" id="cgr:2887533"/>
    <dbReference type="CGD" id="CAL0128818">
        <property type="gene designation" value="CAGL0E05698g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05698g"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030667_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FV08"/>
    <dbReference type="OMA" id="FLWSHLI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017119">
        <property type="entry name" value="Efm1/Rkm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF147">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037136">
        <property type="entry name" value="Ribosomal_Lys-mtfrase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="23"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="599" mass="69223" checksum="65FE5B4F40BE8822" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV30</accession>
    <name>Q6FV30_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0E05192g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445914.1">
        <property type="nucleotide sequence ID" value="XM_445914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV30"/>
    <dbReference type="FunCoup" id="Q6FV30">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV30"/>
    <dbReference type="KEGG" id="cgr:2887290"/>
    <dbReference type="CGD" id="CAL0129098">
        <property type="gene designation" value="CAGL0E05192g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05192g"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FV30"/>
    <dbReference type="OMA" id="HIMDSVE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="345" mass="39858" checksum="600E30745328B4AF" modified="2004-07-19" version="1">MVASNLVKQVRFGGSGLKISPIIIGCMSYGSKKWADWVLEDKEKIFGILKHAYDRGLRTYDTADVYSNGYSERLLKEFFEKYQIKRETVVIMTKVFFGVDEDLNLQPGVKIDEQEDLVLTNQRGLSRKHILEGVKNSTERLGTYIDVLQIHRLDKETPMKEIMKALNDVVEAGYARYIGSSSMLATEFAELQFIAEKHNWFQFVSLQSLYNLLIREDEREIIPFAKRHNIALIPWSPNARGLLTRPLNKTTDRIKSDPTFKYLELDKLTEDQKEIINRVEEVAKKHNTSMAIISNSWVLSKGCNPIVGLNSIDRVDEAIASIDFELPEEDIKYLEEPYLPKKFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVZ5</accession>
    <name>Q6FVZ5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein ICE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0D04202g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVZ5"/>
    <dbReference type="FunCoup" id="Q6FVZ5">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVZ5"/>
    <dbReference type="KEGG" id="cgr:2887154"/>
    <dbReference type="CGD" id="CAL0128407">
        <property type="gene designation" value="CAGL0D04202g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D04202g"/>
    <dbReference type="eggNOG" id="ENOG502QRTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027878_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FVZ5"/>
    <dbReference type="OMA" id="CIYEISP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160031">
        <property type="term" value="P:endoplasmic reticulum membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="57607" checksum="4C475EC142A88EB4" modified="2004-07-19" version="1">MGLITEGVQRSIRISSAALYLVLTLVSIPISFKIGGLQCGLSFTVTLFNLYLISTTLSVLARRSCNRGYVFATSILYYSQHLVIAPLLFLFLSGFSNEEFNRFLSPVGSYQELDPDGSFLDLLKHRILMATTAENSKNWTLYYYYFKFIVQPWQWLLSYSTPFFTLLEGFFTILAIQAIGETNKWLSYEMNSNTWIITSLLVSGGVITGSLYYLYRIYVTPIWKLTIQSASLLGFVLSIVFCLGLYGIISRKGSVIESSLFFAYIVRCIYEISPKLATRATEEILDLVKDVWQTHQRNLLNRDNLLAYYHNVVLKNAEMVWESFILPRSRSLNAMEKIRFWLDVTPVWKFFKNFTVSVPSSIVELVSVTYKMASESLSPAVIVNLCFRILIFYSATRIIPALQRSSYKEQRQSRRILKLLYWYSPCVLIAMYTHLILQYSGELKRELCLWGCTSNWFGSKDQPRIVTDSWSFWNWCNIFWTVLVYANELIGTQAPNELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW82</accession>
    <name>Q6FW82_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Meiosis-specific serine/threonine-protein kinase MEK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0D02244g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW82"/>
    <dbReference type="FunCoup" id="Q6FW82">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW82"/>
    <dbReference type="KEGG" id="cgr:2887012"/>
    <dbReference type="CGD" id="CAL0128119">
        <property type="gene designation" value="CAGL0D02244g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02244g"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="Q6FW82"/>
    <dbReference type="OMA" id="EDQYTIT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22670">
        <property type="entry name" value="FHA_MEK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001021">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="47"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="153"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0128119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54949" checksum="5FE0B439B5932062" modified="2004-07-19" version="1">MDSYLEVIGDFKPGEVLLSGQWGHRVVGHNLAGTPRPRVYIELHNPIKIGRSPKENCMCISNPAISAIHCMVWMILFDETSIPMYYLRDCSLNGTYINGTKLLKENVAILNDGDLIELCENGGKFLKFSCQPSTPSLPKKITINYTENVDNWNISNIVVGNGTFGYVLIAYMGIGAHSGKSSQKITPKCYAVKIVKMKLSKLDKEAKILMQLNHPNIIKVFKTHTDKSNNLYIFQELIPGGDLFSYLAKGDCLMPISQTEALVFVYQILHALKYLHTKGIVHRDLKLDNILLCTPEPFTKIVLADFGIARTVTTMKSRMFTVVGTPEYCAPEVGFKANRKAYHSFFRAATLEQQGYDSKCDLWSLGVITHIMLTGISPFYGDGTEQSIVENAKAGILNFNVSQWSTIDIMAQNFVSKLLEVNVDKRLDCEQCFNHLWISKHQKSLKEIYEKKVLLRFSEKNQMGQPKTELETKYLIEEKINHKGIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWB1</accession>
    <name>Q6FWB1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytosine deaminase</fullName>
            <ecNumber evidence="14">3.5.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FCY1</name>
        <name evidence="18 19" type="ordered locus">CAGL0D01562g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cytosine + H2O + H(+) = uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from cytosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.1" evidence="14"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445483.1">
        <property type="nucleotide sequence ID" value="XM_445483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWB1"/>
    <dbReference type="FunCoup" id="Q6FWB1">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWB1"/>
    <dbReference type="GeneID" id="2887136"/>
    <dbReference type="KEGG" id="cgr:2887136"/>
    <dbReference type="CGD" id="CAL0127965">
        <property type="gene designation" value="FCY1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01562g"/>
    <dbReference type="eggNOG" id="KOG1018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_7_2_1"/>
    <dbReference type="InParanoid" id="Q6FWB1"/>
    <dbReference type="OMA" id="MCTGACL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046087">
        <property type="term" value="P:cytidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019858">
        <property type="term" value="P:cytosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000016">
        <property type="entry name" value="Cytosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF190">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="17">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00084039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0127965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG58394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="155" mass="17046" checksum="3C4963CF6D799067" modified="2004-07-19" version="1">MSNAAQWDALGMKIAYEEAAKGFEEGGVPIGGCLINNKDGTVLGRGHNMRFQKGSPTLHGEISTLENCGRLEGKVYKDTTLYTTLSPCDMCTGAILLYGIPRCVIGESDNFKSPGEEYLKSRGVEVVQMNDEPCKAIMKKFIDTRPQDWFEDIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWC2</accession>
    <name>Q6FWC2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphotyrosine protein phosphatase I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0D01320g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWC2"/>
    <dbReference type="FunCoup" id="Q6FWC2">
        <property type="interactions" value="626"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWC2"/>
    <dbReference type="KEGG" id="cgr:2887199"/>
    <dbReference type="CGD" id="CAL0128149">
        <property type="gene designation" value="CAGL0D01320g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01320g"/>
    <dbReference type="eggNOG" id="KOG3217">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FWC2"/>
    <dbReference type="OMA" id="VCHGNIC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000105">
        <property type="entry name" value="Low molecular weight phosphotyrosine protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="9">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0128149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="160" mass="18441" checksum="91DA9C7D1DBFEF8A" modified="2004-07-19" version="1">MTTDKKLSVAFVCLGNICRSPMAEAVFKHTVKENNLESRFEKIDSFGTAGYHVGESPDSRSSSTCRSHGVPVNHRAQQIRAHHFNEFDYIICMDESNYKSLERIKPKGSRAQIFLFGNWNTDSKFKKIVDDPYYGGKEGFEYNFQQVTYFSNEFLKQELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWE9</accession>
    <name>Q6FWE9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0D00726g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445445.1">
        <property type="nucleotide sequence ID" value="XM_445445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWE9"/>
    <dbReference type="KEGG" id="cgr:2887193"/>
    <dbReference type="CGD" id="CAL0128115">
        <property type="gene designation" value="CAGL0D00726g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00726g"/>
    <dbReference type="eggNOG" id="ENOG502S5RW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1326217_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWE9"/>
    <dbReference type="OMA" id="THEDHIV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="207" mass="24060" checksum="BF41ABB1A853229F" modified="2004-07-19" version="1">MIQGSIKNKLTHVKSLGTVPIKHTIPSRHDSRNKEIVGRVVKQLEFDKYNVQYSRESLKRCLYPSKDILVPIDADRKVEVRNKVLIGQGRHLLNLQWNIAMLRLFKRTPDNLNGFDFNYSEKSSILAELRQRDITRLYVQYLRDHDLKGIARIEIPADRVSSRLQKRQDLQAFLGIMGYISLLNSEPTLINFINRSIIIKIINPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWI5</accession>
    <name>Q6FWI5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0C05401g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445409.1">
        <property type="nucleotide sequence ID" value="XM_445409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWI5"/>
    <dbReference type="KEGG" id="cgr:2886931"/>
    <dbReference type="CGD" id="CAL0127646">
        <property type="gene designation" value="CAGL0C05401g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05401g"/>
    <dbReference type="HOGENOM" id="CLU_2483136_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWI5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0127646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="87" mass="10280" checksum="0050C25C0ED0CC08" modified="2004-07-19" version="1">MLSKLLLTAVNIQLITDGSQIHYFHLRAIEEYVPKIRWKTIMPFTGGFQYDLAVSLFSKTTIRPLFLRLFMLRKIIYQENIDNLFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWI8</accession>
    <name>Q6FWI8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RTG1</name>
        <name evidence="7 8" type="ordered locus">CAGL0C05335g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445406.1">
        <property type="nucleotide sequence ID" value="XM_445406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWI8"/>
    <dbReference type="FunCoup" id="Q6FWI8">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWI8"/>
    <dbReference type="GeneID" id="2886841"/>
    <dbReference type="KEGG" id="cgr:2886841"/>
    <dbReference type="CGD" id="CAL0127494">
        <property type="gene designation" value="RTG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05335g"/>
    <dbReference type="eggNOG" id="ENOG502S1F7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115506_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWI8"/>
    <dbReference type="OMA" id="QNQVDTQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071400">
        <property type="term" value="P:cellular response to oleic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="10"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0127494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="199" mass="21150" checksum="EEE33A01AC0681BE" modified="2004-07-19" version="1">MSTPISQSVPSSSGQMKAARKRNDNMTDKIQELLRLIPAEFFQESYGSGNESGANGETPGPASGAPKLKGTGTKDGRPNKGQILTQAVEYISHLQNQVDTYNREEIELMVKVTELAKETGTIVNDINLENTSAEIALANIGVGPLAAASAGDETQDQNSESKPNSSVSSSVADEENSRGTPKKAQMSKFEYGGYAEYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWN3</accession>
    <name>Q6FWN3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Hexaprenyl pyrophosphate synthase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0C04257g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWN3"/>
    <dbReference type="FunCoup" id="Q6FWN3">
        <property type="interactions" value="597"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWN3"/>
    <dbReference type="KEGG" id="cgr:2886824"/>
    <dbReference type="CGD" id="CAL0127464">
        <property type="gene designation" value="CAGL0C04257g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04257g"/>
    <dbReference type="eggNOG" id="KOG0776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FWN3"/>
    <dbReference type="OMA" id="AFDYYLH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032478">
        <property type="term" value="C:heterotetrameric polyprenyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097269">
        <property type="term" value="F:all-trans-decaprenyl-diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000010">
        <property type="term" value="F:heptaprenyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0127464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52120" checksum="1E9CF259C426BC48" modified="2004-07-19" version="1">MFASTTRCVTLKCRTVRYKSSFAVALETASKLVSPRLLWNNPISLVSNEMNTLAKNIMALIGSGHPTLNRVTSYYFETEGKKVRPLLVLLLSRALSEIPLKERDNIPIDTTDVPEDPMYSKLSSNSSLFDVPVKSISPLHILHGIKPLNPLTKGPEPITQPEFDQERGILPKQRRLAEIVEMIHTASLLHDDVIDYSDTRRGRPSGNVAFSNKMAVLAGDFLLGRATVAISRLKNPEVVELMSNSIANLVEGEFMQLKNMAVEDQPLVGSKNDKILPPPSKKLELKEHDYRVATPEATGSFSHEEVINIAFEYYLHKTYLKTAALISKSSRAAAILSGARDPVIEECYSFGRNIGICFQLVDDLLDFSVSAKDLGKPAGADLKLGIATAPVLFAWKEDPSLGPLIKRNFSEPGDVEKTVKSVQDHDGVGKTMEFAKEYRNKALQNLKNALPESDCRSALEFLTNSIVTRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX07</accession>
    <name>Q6FX07_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0C01441g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX07"/>
    <dbReference type="FunCoup" id="Q6FX07">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX07"/>
    <dbReference type="KEGG" id="cgr:2886933"/>
    <dbReference type="CGD" id="CAL0127184">
        <property type="gene designation" value="CAGL0C01441g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C01441g"/>
    <dbReference type="eggNOG" id="KOG0974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002615_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FX07"/>
    <dbReference type="OMA" id="GGAHRQW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002130">
        <property type="term" value="P:wobble position ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="175"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0127184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1005" mass="113784" checksum="0C314400037BD709" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXC6</accession>
    <name>SWF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Palmitoyltransferase SWF1</fullName>
            <ecNumber>2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SWF1</name>
        <name type="ordered locus">CAGL0B01991g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445056.1">
        <property type="nucleotide sequence ID" value="XM_445056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXC6"/>
    <dbReference type="SMR" id="Q6FXC6"/>
    <dbReference type="FunCoup" id="Q6FXC6">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXC6"/>
    <dbReference type="EnsemblFungi" id="CAGL0B01991g-T">
        <property type="protein sequence ID" value="CAGL0B01991g-T-p1"/>
        <property type="gene ID" value="CAGL0B01991g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886685"/>
    <dbReference type="KEGG" id="cgr:2886685"/>
    <dbReference type="CGD" id="CAL0127124">
        <property type="gene designation" value="CAGL0B01991g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01991g"/>
    <dbReference type="eggNOG" id="KOG1312">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042181_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FXC6"/>
    <dbReference type="OMA" id="STNAYDH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF489">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000212987" description="Palmitoyltransferase SWF1">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="108"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="240"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="3">
        <location>
            <begin position="134"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="330" mass="38744" checksum="852965A498FB24E2" modified="2004-07-19" version="1">MLLFLVFILVVSQVVLLLLSPQFRDKFIFRWYYDEVYKPMILDNSRYRIKFYVVPVFYLSVYSYMVYIFYSRTFAIISPMLTSIETYVVIPLMLILPLFFGSMSMIIKPDSSNAHQIGSEKRYPYDNLLYFPQHECRTCKQVKPARSKHCTVCNSCIYLADHHCVWINNCVGMGNYMYFYSFLCSNLLLLSYSFIRLIFIQFNKSAYNTTPTGEKSLLILSILCGSFTVILAVYCYFVFELVNSGMTTNEKDKWQMVHDYINTGDLVRDPEGKYFIKYQNGGNNYEFYSTDSYDGTQYTIVDYFTVKSPAEITNIYDKGNFINNLREFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXM6</accession>
    <name>Q6FXM6_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAGL0B04565g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXM6"/>
    <dbReference type="FunCoup" id="Q6FXM6">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="CAZy" id="GT15">
        <property type="family name" value="Glycosyltransferase Family 15"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886615"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FXM6"/>
    <dbReference type="OMA" id="GYRHNPF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="401" mass="47250" checksum="1F3BD61381130B7F" modified="2004-07-19" version="1">MSKLRIPPGKEPLVKRIGIALVLFLSTFFLYSTVSGGEFFHSGKPVKGASTAITGNTGYKYTYADEDGHYPESKKVRATFVTLVRNKDLWELLPTIKNVEDRFNRHFHYDWVFLNDEPFTQEFITTTTAMTSGKTKYGLIPREHWSYPEWIDQEKARLTREEMKKQKIIYGFSEPYRHMCRFESGFFYRQKVLDEYEYYWRVEPGTKLHCDVNYDVFKFMKDNGKKYGFTVSLLEYEATIKTLWQTTVEFIKKFPQHLAKNSMLDFISDDQGESYNLCHFWSNFEIASLDLWRGEAYSAYFDYLDHAGGFFYERWGDAPVHSIGAALFLDRDEIHHFGDLGYYHPPFHACPIDENIRLSNRCDCHPNKDFTWVPYSCALKYYNVNKLTKPLGWQEHVGMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY52</accession>
    <name>Q6FY52_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Decapping nuclease</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0A02860g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY52"/>
    <dbReference type="FunCoup" id="Q6FY52">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY52"/>
    <dbReference type="KEGG" id="cgr:2886287"/>
    <dbReference type="CGD" id="CAL0126611">
        <property type="gene designation" value="CAGL0A02860g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02860g"/>
    <dbReference type="eggNOG" id="ENOG502RWNP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_696510_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY52"/>
    <dbReference type="OMA" id="CIRSICK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF25">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="112"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0126611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG57783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="402" mass="46237" checksum="FAFB4BB7B41E9B71" modified="2004-07-19" version="1">MEEVVNQLEALSLSNDKRRVKGQRKGKKKKHGNSRARDDHTVVIRGNKQRLKTSHHKNMPQFYDSAKTLGIFHDHKLYEMNRMDLFPQLKDPIAHIAKSTPAEKTQLVRPFLGISLYENHDKYSPMTAKELDTTEACSTYLDQYENSHGQKYGEDRDFVIVTARHHMIDLAILPFSRQFTNVNLLCAYTPGNLLEISQDPADNTNDKVGVNTDNPILKKICFSGFALEDILTESANDEERNPTFLIVENEIANTRLLMRCEIDAYNPITSHYTELKCYAKYNFGNPNHRRKLLKSWIQTGVIPTTDIVIGVRDTESGCLQDVRCYNRNLLYNKLISKSLPRCDSELNYDPAISVVWYRSLINTLTTTIASLLDKFGRDEPQLFSIKVDNNCNIRIEHRQNPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY56</accession>
    <name>Q6FY56_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0A02772g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY56"/>
    <dbReference type="FunCoup" id="Q6FY56">
        <property type="interactions" value="933"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY56"/>
    <dbReference type="KEGG" id="cgr:2886487"/>
    <dbReference type="CGD" id="CAL0126817">
        <property type="gene designation" value="CAGL0A02772g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02772g"/>
    <dbReference type="eggNOG" id="KOG0282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022571_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY56"/>
    <dbReference type="OMA" id="VQVYDHH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000389">
        <property type="term" value="P:mRNA 3'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000348">
        <property type="term" value="P:mRNA branch site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0126817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG57779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="441" mass="50377" checksum="D2EE37A537AB9D8C" modified="2004-07-19" version="1">MDLLAHYSDSSDELSDQEVVAKPVAEESFDKNGKRKFKFSKAELKRRRKQRKGDGPWGSWDVEVDQKTVQDIDDGGAHDLFDSDHDQETANGPTKLLNEKSTFYGRKERDYQGRSYLHPPADVDVDFKRTQFKCYLPKKVIYRYKGHHNGTTSLRLLPGTGHLILSGGNDNTVKLWDFYHDRKCLRDFVGHSKPIKTLDFTSDSSQFLSGSYDQQVKIWDTETGKVTKRLNTYSTPNSAEFRPTSGNEFVVGLSSSKIKHYDTRVSEKDGLVQVYDHHLSSILAIKYFPDGSKFISSSEDKTLRIWNNQVNIPIKQISDTTQHSMPYIGIHPEHNYFSTQSMDSVIYSYSMKPKYKMHPNKKFKGHNSAGYGIGLTFSPDGRFLCSGDARGQLFLWDWNTNRKLCDLKLPTKSPITQVSWHPKETSKVICSGPDGRIFVLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2025-06-18" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q876N3</accession>
    <accession>Q6FWI6</accession>
    <name>SSB1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Ribosome-associated molecular chaperone SSB</fullName>
            <ecNumber>3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Heat shock protein SSB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Hsp70 chaperone Ssb</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SSB1</name>
        <name type="ordered locus">CAGL0C05379g</name>
    </gene>
    <gene>
        <name type="primary">SSB2</name>
        <name type="ordered locus">CAGL0K04741g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2002-01" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Lachke S.A."/>
                <person name="Srikantha T."/>
                <person name="Soll D.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation-prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP-bound state is characterized by a fast exchange rate of substrate (low affinity state), while in the ADP-bound state exchange is much slower (high affinity state). During the Hsp70 cycle, the chaperone switches between the ATP-bound state (open conformation) and the ADP-bound state (closed conformation) by major conformational rearrangements involving mainly the lid domain. Ssb cooperates with a specific Hsp40/Hsp70 co-chaperone termed the ribosome-associated complex (RAC), which stimulates the ATPase activity of the ribosome-associated pool of Ssbs and switches it to the high affinity substrate binding state. Hsp110 chaperone SSE1 and FES1 act as nucleotide exchange factors that cause substrate release.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds to ribosomes. Binds close to the ribosomal tunnel exit via contacts with both ribosomal proteins and rRNA. Directly interacts with nascent polypeptides. This interaction is dependent on the ribosome-associated complex (RAC). Interacts with SSE1. Interacts with FES1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Associated with translating ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family. Ssb-type Hsp70 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10"/>
    <dbReference type="EMBL" id="AY077689">
        <property type="protein sequence ID" value="AAL86913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445408.1">
        <property type="nucleotide sequence ID" value="XM_445408.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448432.1">
        <property type="nucleotide sequence ID" value="XM_448432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q876N3"/>
    <dbReference type="SMR" id="Q876N3"/>
    <dbReference type="FunCoup" id="Q876N3">
        <property type="interactions" value="2007"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q876N3"/>
    <dbReference type="EnsemblFungi" id="CAGL0C05379g-T">
        <property type="protein sequence ID" value="CAGL0C05379g-T-p1"/>
        <property type="gene ID" value="CAGL0C05379g"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0K04741g-T">
        <property type="protein sequence ID" value="CAGL0K04741g-T-p1"/>
        <property type="gene ID" value="CAGL0K04741g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886843"/>
    <dbReference type="GeneID" id="2890011"/>
    <dbReference type="KEGG" id="cgr:2886843"/>
    <dbReference type="KEGG" id="cgr:2890011"/>
    <dbReference type="CGD" id="CAL0127488">
        <property type="gene designation" value="SSB1"/>
    </dbReference>
    <dbReference type="CGD" id="CAL0133897">
        <property type="gene designation" value="SSB2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_C05379g"/>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K04741g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05379g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04741g"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_0_1_1"/>
    <dbReference type="InParanoid" id="Q876N3"/>
    <dbReference type="OMA" id="NIPPMQA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24093">
        <property type="entry name" value="ASKHA_NBD_HSP70_Ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000014">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000004">
        <property type="entry name" value="Heat shock protein SSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000078367" description="Ribosome-associated molecular chaperone SSB">
        <location>
            <begin position="1"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Nucleotide binding domain (NBD)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Inter-domain linker" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding domain (SBD)" evidence="1">
        <location>
            <begin position="403"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lid domain (SBDalpha)" evidence="1">
        <location>
            <begin position="516"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear export signal" evidence="2">
        <location>
            <begin position="574"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="271"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="G0SCU5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P11484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="613" mass="66396" checksum="16A361603AC31929" modified="2007-01-23" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>B4UMW9</accession>
    <name>B4UMW9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0A01193g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAR57993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002999509.1">
        <property type="nucleotide sequence ID" value="XM_002999463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UMW9"/>
    <dbReference type="STRING" id="284593.B4UMW9"/>
    <dbReference type="KEGG" id="cgr:9487957"/>
    <dbReference type="CGD" id="CAL0126533">
        <property type="gene designation" value="CAGL0A01193g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01193g"/>
    <dbReference type="HOGENOM" id="CLU_2263413_0_0_1"/>
    <dbReference type="InParanoid" id="B4UMW9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0126533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAR57993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="103" mass="11812" checksum="4DC13DC0922BF962" modified="2008-09-23" version="1">MRVTKVRSPVKVYEESRETRQRVLSSVKARLELHDDKENITQNITQNITKSSTLNSATHNCTTANGSPKTTTRRTSLPLRPLDTSRHKGYLHDLRRDTVRALQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2025-06-18" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>P50860</accession>
    <name>ERG3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Delta(7)-sterol 5(6)-desaturase</fullName>
            <ecNumber>1.14.19.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>C-5 sterol desaturase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Ergosterol Delta(5,6) desaturase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Sterol-C5-desaturase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ERG3</name>
        <name type="ordered locus">CAGL0F01793g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Antimicrob. Agents Chemother." volume="39" first="2708" last="2717">
            <title>Deletion of the Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility.</title>
            <authorList>
                <person name="Geber A."/>
                <person name="Hitchcock C.A."/>
                <person name="Swartz J.E."/>
                <person name="Pullen F.S."/>
                <person name="Marsden K.E."/>
                <person name="Kwon-Chung K.J."/>
                <person name="Bennett J.E."/>
            </authorList>
            <dbReference type="PubMed" id="8593007"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>2001-L5</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a Delta(7)-sterol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a Delta(5),Delta(7)-sterol + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:54320"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:138130"/>
            <dbReference type="ChEBI" id="CHEBI:138131"/>
            <dbReference type="EC" id="1.14.19.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The histidine box domains may contain the active site and/or be involved in metal ion binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sterol desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.20"/>
    <dbReference type="EMBL" id="L40390">
        <property type="protein sequence ID" value="AAB02330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446050.1">
        <property type="nucleotide sequence ID" value="XM_446050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P50860"/>
    <dbReference type="FunCoup" id="P50860">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="284593.P50860"/>
    <dbReference type="EnsemblFungi" id="CAGL0F01793g-T">
        <property type="protein sequence ID" value="CAGL0F01793g-T-p1"/>
        <property type="gene ID" value="CAGL0F01793g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887958"/>
    <dbReference type="KEGG" id="cgr:2887958"/>
    <dbReference type="CGD" id="CAL0129591">
        <property type="gene designation" value="ERG3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_F01793g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01793g"/>
    <dbReference type="eggNOG" id="KOG0872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047036_3_0_1"/>
    <dbReference type="InParanoid" id="P50860"/>
    <dbReference type="OMA" id="GPGLWYN"/>
    <dbReference type="UniPathway" id="UPA00768">
        <property type="reaction ID" value="UER00762"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000248">
        <property type="term" value="F:C-5 sterol desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050046">
        <property type="term" value="F:delta7-sterol 5(6)-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0752">Steroid biosynthesis</keyword>
    <keyword id="KW-0753">Steroid metabolism</keyword>
    <keyword id="KW-0756">Sterol biosynthesis</keyword>
    <keyword id="KW-1207">Sterol metabolism</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000117022" description="Delta(7)-sterol 5(6)-desaturase">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="3">
        <location>
            <begin position="188"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine box-1">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine box-2">
        <location>
            <begin position="214"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine box-3">
        <location>
            <begin position="289"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P32353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="364" mass="42735" checksum="91010FD86BC137F0" modified="1996-10-01" version="1">MDLVLETLDHYIFDDVYAKIAPVELQRGIDDSLVNALSLNKIVSNSTLLHETLSITNSLKRVNKDVYGLTPFLFDFTEKTYASLLPRNNLIREFFSLWAVVTVFGLLLYLITASLSYVFVFDRTIFNHPKYLKNQMYLEIKLAVSAIPTMSLLTVPWFMLELNGYSKLYYDVDWEHHGLRKLLIEYATFIFFTDCGIYLAHRWLHWPRVYKALHKPHHKWLVCTPFASHAFHPVDGYFQSLSYHIYPMILPLHKISYLILFTFVNFWSVMIHDGQHMSNNPVVNGTACHTVHHLYFNYNYGQFTTLWDRLGGSYRRPEDSLFDPKLKMDKKVLEKQARETAAYIQEVEGDDTDRVYNTDKKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIX5</accession>
    <name>Q6FIX5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">6-phosphogluconolactonase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M10956g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in regulation of tRNA subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIX5"/>
    <dbReference type="FunCoup" id="Q6FIX5">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIX5"/>
    <dbReference type="KEGG" id="cgr:2891386"/>
    <dbReference type="CGD" id="CAL0136431">
        <property type="gene designation" value="CAGL0M10956g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M10956g"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FIX5"/>
    <dbReference type="OMA" id="KLAWCLP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000017">
        <property type="entry name" value="6-phosphogluconolactonase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="8">
        <location>
            <begin position="79"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="323" mass="35781" checksum="D9B13E1CBE1377C6" modified="2004-07-19" version="1">MTTTVPKVFAFHEFAGVAEAVADHVVHAQESALAEKPKERKHSLTNLSGTVESLEMSRATSVKSVSSTRENSSGKKNGAPKKERRFKIALSGGSLIQVLHEGLLKRTDVKWGKWDIYFADERLVPFSSQESNYGQAKRKILDQIDTEKYGTPNVFHIDESLIDDPQECADNYEKILIKGFAGRDSVKLPMFDLFLLGCAPDGHIASLFPNFQENLREKLAWVVPVENAPSGPSNRISLTIPVICHSHRVTFVVEGATKAPVIKTIMERPEKGLPSSIVNEGAAGRVSWFVDDDALTDVFVTKKKYKFHDAEGLGTENNNDNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ37</accession>
    <name>Q6FJ37_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein mesA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M09493g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ37"/>
    <dbReference type="FunCoup" id="Q6FJ37">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891321"/>
    <dbReference type="CGD" id="CAL0136387">
        <property type="gene designation" value="CAGL0M09493g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09493g"/>
    <dbReference type="eggNOG" id="ENOG502QXS0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020648_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ37"/>
    <dbReference type="OMA" id="GYRFWDH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="82404" checksum="3AFFBBE1825DF69E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ51</accession>
    <name>Q6FJ51_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M09185g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ51"/>
    <dbReference type="FunCoup" id="Q6FJ51">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ51"/>
    <dbReference type="KEGG" id="cgr:2891307"/>
    <dbReference type="CGD" id="CAL0137489">
        <property type="gene designation" value="CAGL0M09185g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09185g"/>
    <dbReference type="eggNOG" id="KOG3060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065213_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ51"/>
    <dbReference type="OMA" id="LMEMLFY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045050">
        <property type="term" value="P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="293" mass="34249" checksum="9C30F1D29E880E34" modified="2004-07-19" version="1">MRDLRREKLLTVMTTRAYTRFEPQELVQLYNELLMRMGKLERSSEPNDVSLLEMYFYVCCYLGKDQEMSLVFQRLRDRFGESSPRVAVMKATMMEVEGNDSSAAKQYLEGRLKELEYDADSVSYVMLSKKLLALKMRDLKKNPQQQLKETLALIEKFPLDPELQWVCSELYYSLKDLDKAIYCIEEVLVAMPFNYVAFARLSELLYYKYVREFQDKPAKRRDTAALQQALDNALRSVELSELFLKGWSLVATISKELDKPQLLQLSKKKLQEISEVSNSNDARIAKKFLQKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJF9</accession>
    <name>Q6FJF9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M06611g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJF9"/>
    <dbReference type="FunCoup" id="Q6FJF9">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJF9"/>
    <dbReference type="KEGG" id="cgr:2891683"/>
    <dbReference type="CGD" id="CAL0136791">
        <property type="gene designation" value="CAGL0M06611g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06611g"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009020_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FJF9"/>
    <dbReference type="OMA" id="FAFTGHQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF224">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="6"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="485" mass="53634" checksum="96F68E79386D6F67" modified="2004-07-19" version="1">MIDNPTATVGSSITNLVKTIVGAGLFAIPFAFKNDGVAVGLLLIFLAAVTSSFGLILLAKCSKTLINPRNSSFFTICMLTYPSLAPLFDLAMVVQCFGVGLSYLVLVGDFFPDLFGGERKYWILLSAILVVPLCCLKKLDNLKYSSIVGVIALLYLSLLIGFRYLTDVAFAPEISFERGEISWFKVYDYKGLLSTFSIIIFAYVGAMNIFTIVNELQDNSMTNVRKVVDSSILISTILFLFVGLFGYLTFGSLTMGNILLNYDSDSLAIGIGKFCLAMMLILTFPLLFHPLRTAINNIVVWFIIKFEKSSLTPEISARDSEASNYVTAETHTSRPINLIINDDEVNDCEELNEDLLDSNNVIYQEHGHEEEPPKGGLNGVEHDVPFPETRFYIITALLLVSMYAMALNVKSFALVLSLVGATGSTSISFILPGLFGYKLIGTDALAIGHTMTKEDRLYRRLSLLLIYFGFAVMFLSLYVTLKYQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJM4</accession>
    <name>Q6FJM4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease III</fullName>
            <ecNumber evidence="2">3.1.26.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M05159g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="2"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJM4"/>
    <dbReference type="FunCoup" id="Q6FJM4">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJM4"/>
    <dbReference type="KEGG" id="cgr:2891582"/>
    <dbReference type="CGD" id="CAL0136809">
        <property type="gene designation" value="CAGL0M05159g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05159g"/>
    <dbReference type="eggNOG" id="KOG1817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026251_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJM4"/>
    <dbReference type="OMA" id="MIIYNKF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034963">
        <property type="term" value="P:box C/D sno(s)RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000001">
        <property type="entry name" value="Ribonuclease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040540">
        <property type="entry name" value="RNase_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18497">
        <property type="entry name" value="RNase_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="182"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="420"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="449" mass="50841" checksum="68C2170535F28E3F" modified="2004-07-19" version="1">MGKIGKVGKASKKKSRLTSELVDLYEKNSTEQVGTYQYSNAIQIEHAVHKLVEAYQRILKLSPNIVQYYETLNSLSDPEKVPPQLISLFTRYPLKLAAEIKTLHDLNKSTLLDDISGYEAKFDASNREPVLGDLELSDLQDLEDDDIGRLDLDLSVAKSSESSECITSKEKSSKWPPEMPEIKDHVIRARVFMHKSLVNDKVYLNESDIIKSNNERLEFLGDSILNTVMTMIIYNKFPSLNEGNLTELRKKLVKNETLREWSELYELPKQLKSNLSPDVDLSTSKTSADIFEAYIGGLMEDDPKTNLVKIRKWLKKLAKPKIEEAMKTSIQLEPTNNLDMNAKRKLYSLIGYAALKLHYHTVQRPTNENPVTIVQCRTGDGTILGVGKARNIKLAGVKAAEDVLRKEDVIEKYAKLRASIPREQSVSKNEQPRTTNKEQGEKDICELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJT2</accession>
    <name>Q6FJT2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein YPT11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0M03817g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJT2"/>
    <dbReference type="KEGG" id="cgr:2891522"/>
    <dbReference type="CGD" id="CAL0137147">
        <property type="gene designation" value="CAGL0M03817g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03817g"/>
    <dbReference type="eggNOG" id="KOG0087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030444_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJT2"/>
    <dbReference type="OMA" id="WHQVVER"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090167">
        <property type="term" value="P:Golgi distribution to daughter cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="401"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0137147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="53634" checksum="47A62B2DE9CFE5F9" modified="2004-07-19" version="1">MADGRRKRYSLNVVVSPSPSERRFSGMDFTEASGTSPWNSPFGGGSTESFHFDKSNRNSRHSFYRTLSSSNSLSGGSVYRNSSVGLGLSSSAYMNDVMCSRESLSMSAIESNAANIKVLFIGDAGVGKTAMILNYCRELPTRAQWEHIIGLSPTPNRAGSSNRSGRNQMVRRSLTARAYERKSDIMQDQRKRYSSTDYDDYKENDFMAQRDFKIVKDVESESSSLNYDPEELIVDTKTTIGVDIKTNIINIDNRIFNCILWDTAGQERYRNAIMPSLYKKSNAIILSYDITDKCSFKNSYEHWLVEAMGHFAARDYEKARFYFIGNKTDLYKQREVTHEDVIAAIEEIESRYGLVIAGNFEVTCKNFDSLNEAMNNITVDLVNNGCYEEKAEQELEGTAVLEEDEEMKESTTLNEQYDDEVVSTSNDEDSGEDSDGSLEPVIRKRTTAKTRIIDISKPKNQPNILDTSHKMSCCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJX5</accession>
    <name>Q6FJX5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M02805g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJX5"/>
    <dbReference type="FunCoup" id="Q6FJX5">
        <property type="interactions" value="484"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJX5"/>
    <dbReference type="KEGG" id="cgr:2891477"/>
    <dbReference type="CGD" id="CAL0136275">
        <property type="gene designation" value="CAGL0M02805g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02805g"/>
    <dbReference type="eggNOG" id="KOG1963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_348179_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJX5"/>
    <dbReference type="OMA" id="KWHIDSV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="288"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="872" mass="97776" checksum="262998A831C1E6B9" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJY0</accession>
    <name>Q6FJY0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M02695g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJY0"/>
    <dbReference type="FunCoup" id="Q6FJY0">
        <property type="interactions" value="1390"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJY0"/>
    <dbReference type="KEGG" id="cgr:2891472"/>
    <dbReference type="CGD" id="CAL0136787">
        <property type="gene designation" value="CAGL0M02695g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02695g"/>
    <dbReference type="eggNOG" id="KOG0875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056222_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FJY0"/>
    <dbReference type="OMA" id="CQIASAH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="6">
        <location>
            <begin position="236"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="297" mass="33705" checksum="A9D8552A573FEFE2" modified="2004-07-19" version="1">MVFIQNLKTSAYHSRFQTPFRRRREGKTDYYQRKRLVAQHKAKYNSPKYRLVVRFTNKDIICQIVSSTITGDIVLAAAYSHELPRYGITHGLTNWAAAYATGLLIARRALQKLGLDETYKGVEEVEGEYELTEAVEDGPRPFKVYLDIGLQRTTTGARVFGALKGASDGGLYVPHSENRFPGWDFEAEELDAELLRSYIFGGHVSQYMEELADDDEERFSELFKGYLADDIDADSIEDIYASAHEAIRADPSFKPTEKKFTKEQYAAESKKYKAKKLTKEERDARVAAKIAALAGQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK07</accession>
    <name>PET20_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein PET20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PET20</name>
        <name type="ordered locus">CAGL0M02101g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory growth, stability of the mitochondrial genome and for proper assembly or maintenance of mitochondrial proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449437.1">
        <property type="nucleotide sequence ID" value="XM_449437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK07"/>
    <dbReference type="FunCoup" id="Q6FK07">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK07"/>
    <dbReference type="EnsemblFungi" id="CAGL0M02101g-T">
        <property type="protein sequence ID" value="CAGL0M02101g-T-p1"/>
        <property type="gene ID" value="CAGL0M02101g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891763"/>
    <dbReference type="KEGG" id="cgr:2891763"/>
    <dbReference type="CGD" id="CAL0136269">
        <property type="gene designation" value="CAGL0M02101g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02101g"/>
    <dbReference type="eggNOG" id="ENOG502S1JN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074423_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK07"/>
    <dbReference type="OMA" id="DPLPWIS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014804">
        <property type="entry name" value="Pet20-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08692">
        <property type="entry name" value="Pet20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000240389" description="Protein PET20, mitochondrial">
        <location>
            <begin position="45"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="267" mass="29928" checksum="75F49848619E7FB6" modified="2004-07-19" version="1" precursor="true">MSVSLVLCTWGGAARTARVYRVVKQAMIRTMFVRLRSAGQVRYQSSFSFPSSQSLLQKGQLGKKKRSVRKLGLGISDKKQYNSGVTSAAQEAGGAVRDLKSEKAQTKKKVYDYSTLPRVEQISDTKLKNMSTEVLYSGYRPLFFDVEPKNSQEGKTLYEFAMKLEEFQEAMSPWVSSATGSEMYAEWDNVPGDVIKDLKPFTPPVVNSRKLNGATGENANDFDEQGNFQKKAFFDKVQSILNRNGKGGRKRPGVTVLKHLKKLKEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK45</accession>
    <name>Q6FK45_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">STE12</name>
        <name evidence="7 8" type="ordered locus">CAGL0M01254g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449399.1">
        <property type="nucleotide sequence ID" value="XM_449399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK45"/>
    <dbReference type="STRING" id="284593.Q6FK45"/>
    <dbReference type="GeneID" id="2891169"/>
    <dbReference type="KEGG" id="cgr:2891169"/>
    <dbReference type="CGD" id="CAL0137181">
        <property type="gene designation" value="STE12"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01254g"/>
    <dbReference type="eggNOG" id="ENOG502QTVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_456329_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK45"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000220">
        <property type="term" value="P:regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="529"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0137181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="598" mass="67690" checksum="34432C2A8338B6D6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK79</accession>
    <name>Q6FK79_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA element modulatory factor 1 TATA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M00462g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK79"/>
    <dbReference type="FunCoup" id="Q6FK79">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK79"/>
    <dbReference type="KEGG" id="cgr:2891588"/>
    <dbReference type="CGD" id="CAL0137245">
        <property type="gene designation" value="CAGL0M00462g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00462g"/>
    <dbReference type="eggNOG" id="KOG4673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018551_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK79"/>
    <dbReference type="OMA" id="NSHTWET"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="491"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="464"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="103"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="502"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0137245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="611" mass="70386" checksum="28B991D71BAE5DD2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKC6</accession>
    <name>SSN3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber>2.7.11.22</ecNumber>
            <ecNumber>2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Cyclin-dependent kinase 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SSN3</name>
        <name type="synonym">CDK8</name>
        <name type="ordered locus">CAGL0L12650g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22"/>
    <dbReference type="EC" id="2.7.11.23"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449318.1">
        <property type="nucleotide sequence ID" value="XM_449318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKC6"/>
    <dbReference type="SMR" id="Q6FKC6"/>
    <dbReference type="FunCoup" id="Q6FKC6">
        <property type="interactions" value="1237"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKC6"/>
    <dbReference type="EnsemblFungi" id="CAGL0L12650g-T">
        <property type="protein sequence ID" value="CAGL0L12650g-T-p1"/>
        <property type="gene ID" value="CAGL0L12650g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890604"/>
    <dbReference type="KEGG" id="cgr:2890604"/>
    <dbReference type="CGD" id="CAL0135266">
        <property type="gene designation" value="CAGL0L12650g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12650g"/>
    <dbReference type="eggNOG" id="KOG0666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_6_1"/>
    <dbReference type="InParanoid" id="Q6FKC6"/>
    <dbReference type="OMA" id="IYMVSEF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990508">
        <property type="term" value="C:CKM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060258">
        <property type="term" value="P:negative regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000774">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000312939" description="Serine/threonine-protein kinase SSN3">
        <location>
            <begin position="1"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="74"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="567" mass="63532" checksum="4CED3A8B663AC2EF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKM5</accession>
    <name>Q6FKM5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CYT1</name>
        <name evidence="20 21" type="ordered locus">CAGL0L10406g</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449219.1">
        <property type="nucleotide sequence ID" value="XM_449219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKM5"/>
    <dbReference type="FunCoup" id="Q6FKM5">
        <property type="interactions" value="751"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKM5"/>
    <dbReference type="GeneID" id="2891070"/>
    <dbReference type="KEGG" id="cgr:2891070"/>
    <dbReference type="CGD" id="CAL0136002">
        <property type="gene designation" value="CYT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10406g"/>
    <dbReference type="eggNOG" id="KOG3052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040334_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FKM5"/>
    <dbReference type="OMA" id="WVKKFKW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="19">
        <location>
            <begin position="78"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0136002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG62193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="299" mass="33140" checksum="AF7F7A82EC007495" modified="2004-07-19" version="1">MFSTINRRFATRSFSMARELPKTSKLLVGGATLTAITTSALLYADSLTAEAMTAAEHGLHAPSYAWSHNGPLQTFDHASIRRGYQVYREVCAACHSLDRVAWRTMVGVSHTNEEVREMAAEFEYDDEPDEQGNPKKRIGKLSDYIPGPYPNEQAARAANQGALPPDLSLIVKARHGAADYIFALLTGYPDDPPAGVQLPPGTNYNPYFPGGAISMARVLFDDLVEYEDGTPATTSQMAKDVTTFLNWCAEPEHDERKKAGLKALLLLSSLYLLSVWVKKFKWAAIKNRKFVFNPPKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKM7</accession>
    <name>Q6FKM7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L10362g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449217.1">
        <property type="nucleotide sequence ID" value="XM_449217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKM7"/>
    <dbReference type="FunCoup" id="Q6FKM7">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891068"/>
    <dbReference type="CGD" id="CAL0135704">
        <property type="gene designation" value="CAGL0L10362g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10362g"/>
    <dbReference type="eggNOG" id="ENOG502RYV2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058084_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKM7"/>
    <dbReference type="OMA" id="INWNKDT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="252" mass="29893" checksum="A4879552D81C627F" modified="2004-07-19" version="1">MTSLDDTIISRQNLMLLDNVTNYNKPALDYFHQDFDYSTMDISLSWSLLLKMRKHKVLRLPSCSNEDDLDYNIYLERLHHCLWRRWSMKLFKLEDIRLDPLAINWNKDTDVTVLYGPDLSVPEANNRTEPKKKSKPTLKSCLAHSADDDEEAEYYNDFSSKYDYSSSVNSSTSSIFEKTYSKDEDELPQKKSLRFDDAVFKRVIDHSGNYHEIYTIINDKREQWRREQKRMYSRHKNSHSIDFGNAPPMYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKZ0</accession>
    <name>Q6FKZ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Temperature shock-inducible protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIR6</name>
        <name evidence="3 4" type="ordered locus">CAGL0L07502g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449104.1">
        <property type="nucleotide sequence ID" value="XM_449104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKZ0"/>
    <dbReference type="STRING" id="284593.Q6FKZ0"/>
    <dbReference type="KEGG" id="cgr:2890992"/>
    <dbReference type="CGD" id="CAL0136056">
        <property type="gene designation" value="TIR6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07502g"/>
    <dbReference type="eggNOG" id="ENOG502RZ9R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071083_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKZ0"/>
    <dbReference type="OMA" id="LYSEVNM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000992">
        <property type="entry name" value="SRP1_TIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00660">
        <property type="entry name" value="SRP1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00724">
        <property type="entry name" value="SRP1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273435" description="Temperature shock-inducible protein 1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0136056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="22416" checksum="1DA50903F63EF480" modified="2004-07-19" version="1">MSKFAVLIAAIAATLVNAQNAVEVAEIQVLVNDINSNLAQYLSLETNPDSGFQIPDNLLSLYRNVATYTDDSFSTLLSGVNFDEITSTIVGLPWYSSRLLPALESASSAAAGSGDAAAAPASANASSVSAAVTSLSSAINSTSSASASATGAVVTSANLTSVSANSTRSGSRSATRSASATGGVAGGNRTNGSTNGTKTSSTKSKNGVAKVEAGLAGALLAGAAAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL00</accession>
    <name>Q6FL00_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Binder of USO1 and GRH1 protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L07282g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL00"/>
    <dbReference type="FunCoup" id="Q6FL00">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890982"/>
    <dbReference type="CGD" id="CAL0135540">
        <property type="gene designation" value="CAGL0L07282g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07282g"/>
    <dbReference type="eggNOG" id="ENOG502S1CR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076662_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL00"/>
    <dbReference type="OMA" id="NWNVDMT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0135540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38871" checksum="EC4CC2E197B247FB" modified="2004-07-19" version="1">MSDTEEDKRAKQLEEARKRVEELKNKKNKKKNKKKKNKDKEGDDKAAAVEANDSANEITEATETADSTEALEVPDSKEATPAEEVKQTEDEEIETKDDDLQEESVVADTKEESIPTEEAKVVDEAQKTIEDVEELTREVETKLQGDINEKKAAEEEYTDKKEEPKAQDGLDDMFGNDDNSNDFISTINKEKEADEISELKKEIEKLIAENKTLKFANIDHETVIEELQEENAKYKEMLELTQNDLQQVKNELLQTQVKLNEVSQNNNKPVNASPTLQFAKFNSNSETSNYAPSNSTGQTPKLNTYGIAQTQTVDRAMLQKWRNWNIDMTTWRSIGSGPIVEF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL44</accession>
    <name>ARX1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Probable metalloprotease ARX1</fullName>
            <ecNumber>3.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Associated with ribosomal export complex protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ARX1</name>
        <name type="ordered locus">CAGL0L06314g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24 family.</text>
    </comment>
    <dbReference type="EC" id="3.-.-.-"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449050.1">
        <property type="nucleotide sequence ID" value="XM_449050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL44"/>
    <dbReference type="SMR" id="Q6FL44"/>
    <dbReference type="FunCoup" id="Q6FL44">
        <property type="interactions" value="435"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL44"/>
    <dbReference type="EnsemblFungi" id="CAGL0L06314g-T">
        <property type="protein sequence ID" value="CAGL0L06314g-T-p1"/>
        <property type="gene ID" value="CAGL0L06314g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890758"/>
    <dbReference type="KEGG" id="cgr:2890758"/>
    <dbReference type="CGD" id="CAL0135380">
        <property type="gene designation" value="CAGL0L06314g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L06314g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06314g"/>
    <dbReference type="eggNOG" id="KOG2776">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477525_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL44"/>
    <dbReference type="OMA" id="KPSWVHS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF102">
        <property type="entry name" value="METALLOPROTEASE ARX1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000148994" description="Probable metalloprotease ARX1">
        <location>
            <begin position="1"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="588" mass="64730" checksum="A91E7B8CAF9F74BC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLA2</accession>
    <name>Q6FLA2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L05016g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLA2"/>
    <dbReference type="FunCoup" id="Q6FLA2">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLA2"/>
    <dbReference type="KEGG" id="cgr:2890717"/>
    <dbReference type="CGD" id="CAL0135206">
        <property type="gene designation" value="CAGL0L05016g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05016g"/>
    <dbReference type="eggNOG" id="ENOG502QT8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010065_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLA2"/>
    <dbReference type="OMA" id="GDIREVW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0135206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="804" mass="93167" checksum="CDEC581BD003BD80" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLF5</accession>
    <name>Q6FLF5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L03806g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLF5"/>
    <dbReference type="FunCoup" id="Q6FLF5">
        <property type="interactions" value="935"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLF5"/>
    <dbReference type="KEGG" id="cgr:2890544"/>
    <dbReference type="CGD" id="CAL0135596">
        <property type="gene designation" value="CAGL0L03806g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03806g"/>
    <dbReference type="eggNOG" id="KOG4208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025741_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FLF5"/>
    <dbReference type="OMA" id="HGFHEKE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="125"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="255" mass="29300" checksum="5B5C88DED982F18A" modified="2004-07-19" version="1">MGLSAMLCIGIYILWRIVIVCRYHPISGFRKGLEYQREITMAKSTDKKKVVAKEAEVQEDAIRLESGSDLSSESGESELEVSESESEDEIEGMETEQSGHHIKKLDTSKKQKATKKDDKDSDISGIIYVGRLPKGFHERELSKYFSQFGDLKEVRLARNKKTGNSRHYGFVQFVNTDDSRVAYDTMNNYLLMGHLLQVRLLPKGSKIEKLYKYKQRAFMSPPKAKKSAKELKKLAEEKHKERMEKLSKAGIDYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLK8</accession>
    <name>Q6FLK8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dipeptidyl aminopeptidase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0L02651g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9B family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLK8"/>
    <dbReference type="FunCoup" id="Q6FLK8">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLK8"/>
    <dbReference type="ESTHER" id="canga-q6flk8">
        <property type="family name" value="DPP4N_Peptidase_S9"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.005"/>
    <dbReference type="KEGG" id="cgr:2890858"/>
    <dbReference type="CGD" id="CAL0136168">
        <property type="gene designation" value="CAGL0L02651g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02651g"/>
    <dbReference type="eggNOG" id="KOG2100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006105_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FLK8"/>
    <dbReference type="OMA" id="NYDMHIF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF160">
        <property type="entry name" value="DIPEPTIDYL AMINOPEPTIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="10">
        <location>
            <begin position="240"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="9">
        <location>
            <begin position="699"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0136168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="909" mass="105256" checksum="8DBFCE4247F440A3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLM4</accession>
    <name>Q6FLM4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VPS1</name>
        <name evidence="9 10" type="ordered locus">CAGL0L02299g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448870.1">
        <property type="nucleotide sequence ID" value="XM_448870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLM4"/>
    <dbReference type="FunCoup" id="Q6FLM4">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLM4"/>
    <dbReference type="GeneID" id="2890900"/>
    <dbReference type="KEGG" id="cgr:2890900"/>
    <dbReference type="CGD" id="CAL0136106">
        <property type="gene designation" value="VPS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02299g"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008964_5_2_1"/>
    <dbReference type="InParanoid" id="Q6FLM4"/>
    <dbReference type="OMA" id="IQRRKEC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060988">
        <property type="term" value="P:lipid tube assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000473">
        <property type="entry name" value="Vacuolar sorting-associated 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF220">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="8">
        <location>
            <begin position="26"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="7">
        <location>
            <begin position="614"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="700" mass="78349" checksum="5811F07518FACD94" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLQ9</accession>
    <name>Q6FLQ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-processing factor 39</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L01441g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PRP39 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG61805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="284593.Q6FLQ9"/>
    <dbReference type="KEGG" id="cgr:2890874"/>
    <dbReference type="CGD" id="CAL0135948">
        <property type="gene designation" value="CAGL0L01441g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01441g"/>
    <dbReference type="eggNOG" id="KOG1258">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007434_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FLQ9"/>
    <dbReference type="OMA" id="SLELWCD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204">
        <property type="entry name" value="PRE-MRNA PROCESSING PROTEIN PRP39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17204:SF5">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="70871" checksum="A5E2135EBE9EB123" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLS0</accession>
    <name>Q6FLS0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fumarate reductase</fullName>
            <ecNumber evidence="6">1.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">FRDS1</name>
        <name evidence="8 9" type="ordered locus">CAGL0L01177g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Irreversibly catalyzes the reduction of fumarate to succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="6">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="6"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLS0"/>
    <dbReference type="FunCoup" id="Q6FLS0">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLS0"/>
    <dbReference type="KEGG" id="cgr:2890915"/>
    <dbReference type="CGD" id="CAL0135866">
        <property type="gene designation" value="FRDS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01177g"/>
    <dbReference type="eggNOG" id="KOG2404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_5_1"/>
    <dbReference type="InParanoid" id="Q6FLS0"/>
    <dbReference type="OMA" id="MAWAHGA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000007">
        <property type="entry name" value="NADH-dependent fumarate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF7">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="7">
        <location>
            <begin position="4"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0135866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="465" mass="49578" checksum="CF77042D711897E6" modified="2004-07-19" version="1">MATVIVGTGLAGLTCANQLLELGKSPVILLDKTGTIGGNSTKASSGINGAHTRTQEAQNIQDNPELFYQDTVKSSKGRGVTDLMDKLANDSHLAIQWLQEEFGLSLDLLAQLGGHSVARTHRSSGKLPPGFEIVSTLSKRLKEIAEKEPEKCKIILNANVVDVNINNEKAITGVIYKDGEGKEIQLDANNVVFCSGGFGFSKDMLKKYAPETVDLPTTNGPQTTGDGQRILEKIGADMIDMDQIQVHPTGFIDPEDPSAGSKFLAAEALRGLGGILLNPSTGKRFVNELSTRDAVTNAIQTHCPKEKNTALLVMGEGIYEKCKVNLDFYMFKKLVNKITIAELVKKYEVPVDAKEVASEINSYNVSSSDSFGRTLVIQNFGENVTQDTTVFVGEVTPVVHFTMGGAKINTSSEVVGKDGQVVANGLYAAGEVSGGVHGANRLGGSSLLECVVFGRTAAKTIASKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLY1</accession>
    <name>Q6FLY1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K12584g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLY1"/>
    <dbReference type="FunCoup" id="Q6FLY1">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="ESTHER" id="canga-q6fly1">
        <property type="family name" value="Duf_726"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890418"/>
    <dbReference type="CGD" id="CAL0134861">
        <property type="gene designation" value="CAGL0K12584g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12584g"/>
    <dbReference type="eggNOG" id="KOG2385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001695_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FLY1"/>
    <dbReference type="OMA" id="KEVGWEV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035650">
        <property type="term" value="F:AP-1 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035652">
        <property type="term" value="P:clathrin-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="985"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1059"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="482"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="985"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61726.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1112" mass="122372" checksum="E4B29052C997CE78" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMA1</accession>
    <name>Q6FMA1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small ribosomal subunit protein uS4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0K09768g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG61606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene designation" value="CAGL0K09768g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09768g"/>
    <dbReference type="eggNOG" id="ENOG502QTS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026386_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMA1"/>
    <dbReference type="OMA" id="GDMFQVE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000025">
        <property type="entry name" value="30S ribosomal subunit S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
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        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
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        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="11">
        <location>
            <begin position="103"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071419"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0133891"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG61606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="484" mass="56113" checksum="80CCFA7C2A59DACA" modified="2004-07-19" version="1">MPRKAVLLNSLTRGRVRTSFNKYNLFNLYKKGNIDFRSKSLYQQKWSAKQETRAYHGEHITESRWQTMFSPKLDSVAQLDASLRGGVTKETPFLMQTFATLEKRLDFAVFRAMFASSVRQARQFILHGNVYVNGVKIKHPGYTLKPGDTFNVKPEKVLQALGSKKPSFEEALKVDKKQVVLWNKYVKEAKTNPQKAWSDKVAKFESMLDTNEKKHEFLKRLKKEDTNLQNEEYKILKALTPKDILAEIISIHLKKAKDDTTPVPIEEFKTLAKYDEAILPTIHKIYETYLFSKTILLDKLKGKNKEEIKEFASSLISPKDDAKKDLIASSKTSLREGKNQLSDFVKKYSQSVINHFKNKQTDGSIANSSFDPKWAENLKYHPRLDLEAIKEDEVKAREAINLPWQSKHLYGRKDSNKPYFTPWKPRPFLAPFAILPHHLEISFKTCHAVYLRDPVARPGHSEVISPFDIPVHERAYMYYIRRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMA7</accession>
    <name>Q6FMA7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial import receptor subunit TOM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0K09592g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMA7"/>
    <dbReference type="FunCoup" id="Q6FMA7">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMA7"/>
    <dbReference type="KEGG" id="cgr:2890239"/>
    <dbReference type="CGD" id="CAL0134901">
        <property type="gene designation" value="CAGL0K09592g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09592g"/>
    <dbReference type="eggNOG" id="KOG4111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094333_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FMA7"/>
    <dbReference type="OMA" id="QGAQHML"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0134901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG61600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15793" checksum="29FC4A2FF8D5A33F" modified="2004-07-19" version="1">MVELTEIKEDTVQDPPVTPAGLGDVAVKGARVEDEEDDSDFEDDFDENETLLDRVKALKDIIPPQHKNRICAVFSTSCSIIKSAFTRGSGLAWTLTTSALLLGVPLSLSILAEQQLIEMEKTFDLQKDANDILAQGDEKNTVATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMB4</accession>
    <name>Q6FMB4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0K09438g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMB4"/>
    <dbReference type="FunCoup" id="Q6FMB4">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMB4"/>
    <dbReference type="KEGG" id="cgr:2890232"/>
    <dbReference type="CGD" id="CAL0134341">
        <property type="gene designation" value="CAGL0K09438g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09438g"/>
    <dbReference type="eggNOG" id="KOG1968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019060_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMB4"/>
    <dbReference type="OMA" id="RDINFIP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF11">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN ELG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="343"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0134341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="775" mass="89457" checksum="89E901BABBEF3D6E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FME6</accession>
    <name>Q6FME6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET28</name>
        <name evidence="9 10" type="ordered locus">CAGL0K08668g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448598.1">
        <property type="nucleotide sequence ID" value="XM_448598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FME6"/>
    <dbReference type="FunCoup" id="Q6FME6">
        <property type="interactions" value="3621"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FME6"/>
    <dbReference type="GeneID" id="2890279"/>
    <dbReference type="KEGG" id="cgr:2890279"/>
    <dbReference type="CGD" id="CAL0134269">
        <property type="gene designation" value="MET28"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08668g"/>
    <dbReference type="eggNOG" id="ENOG502S9W2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098757_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FME6"/>
    <dbReference type="OMA" id="NKENEFW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089713">
        <property type="term" value="C:Cbf1-Met4-Met28 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031335">
        <property type="term" value="P:regulation of sulfur amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF45">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR OF SULFUR METABOLISM MET28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="89"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="220" mass="24644" checksum="BDE97173E56644F1" modified="2004-07-19" version="1">MGLENTELPSSVLGVSERIRSMIMENSELGSRLVSLLLVNSGNAAEIIESINKGGASNVRSKSKHKSNEVKPVVAGAQSDRDYTYKNTTEDARVSGDDDEDAVVTTSSQWDNRAITTTGGHSSANSEDEVEDNESLLLKALEKRRKNSEASARFRIRKKQRRMENLEKLAQLNSHIDDLNKKIDGLLQENRHWKSKLEEINEQKSKQLLEQIKKKNGILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMK9</accession>
    <name>Q6FMK9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0K07161g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448535.1">
        <property type="nucleotide sequence ID" value="XM_448535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMK9"/>
    <dbReference type="STRING" id="284593.Q6FMK9"/>
    <dbReference type="KEGG" id="cgr:2890394"/>
    <dbReference type="CGD" id="CAL0134865">
        <property type="gene designation" value="CAGL0K07161g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07161g"/>
    <dbReference type="eggNOG" id="KOG1764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021740_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FMK9"/>
    <dbReference type="OMA" id="YTCSPDD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="117"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="194"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="262"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0134865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="320" mass="36478" checksum="EB736BAE06FF5737" modified="2004-07-19" version="1">MPGVQNTEGVIEEQRAALESCRHFLRGKSSYDILPVSYRMIVLESGLPVKRALNVLIQNKVLSAPIWDSKRSRFAGILTLMDFIGLVQYFFSNPDQFDTMDKLRLKDLKEIEYSIGMHAPLENCTIHPERSLFEACELMLQSQTRKIALLDKEDFTERELVVGMLTQYRILKFLVLNYKDVHFMHRSINSLQLGTRKNIKSCKMETPLIDTIQLMTTHEVSSVPILDENGVLLNAYEASDILGLVKGGIYNDLSLCVGEALMRRGDDYEGIYTCTGEDKLATIFDIIRKSRVHTFYLVDENGRLIGILTLGDLLRYIIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FML2</accession>
    <name>Q6FML2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0K07095g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FML2"/>
    <dbReference type="FunCoup" id="Q6FML2">
        <property type="interactions" value="834"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FML2"/>
    <dbReference type="KEGG" id="cgr:2890391"/>
    <dbReference type="CGD" id="CAL0134113">
        <property type="gene designation" value="CAGL0K07095g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07095g"/>
    <dbReference type="eggNOG" id="KOG1523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034396_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FML2"/>
    <dbReference type="OMA" id="YVWEPSP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000682">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="371" mass="40844" checksum="12B8DF943DDA60F4" modified="2004-07-19" version="1">MSDNSVLKVFKLVKAPIYSHCFSADRSVLAISCEANCLIYRVGGPTPQLVATLANHDKLVTAVDISPHGRIVTCSQDRNAYVWEPLSDGSYKPTLVLLRINRAATSVSWAPSGYKFAVGSSARIIAVCYYEHENNWWVSKHIKKPIKSTINCLSWHTNGVLLAAGGTDGYMRVFSGFIKGLDSKESVAGSPWGDKFPFGSLVKEWYQGSYIHDVKWRSSQEQIAFVTHDAKLNIVDSQNGYEFTDSPDGLPFKALVWINDNEILCGGYSCHPVLFSKSSQGWKFSKNIDKIGAKTPTPQVGGEDEDENPTFGMSALKKFKELDLKGKVSVEVQESAHENTITELAPFAESNGQVTEVSSCGLDGKIVIYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMN6</accession>
    <name>Q6FMN6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial fusion and transport protein UGO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0K06545g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMN6"/>
    <dbReference type="FunCoup" id="Q6FMN6">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMN6"/>
    <dbReference type="KEGG" id="cgr:2890440"/>
    <dbReference type="CGD" id="CAL0134539">
        <property type="gene designation" value="CAGL0K06545g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06545g"/>
    <dbReference type="eggNOG" id="ENOG502RQI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029376_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMN6"/>
    <dbReference type="OMA" id="ELWRGWR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990627">
        <property type="term" value="P:mitochondrial inner membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990626">
        <property type="term" value="P:mitochondrial outer membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0134539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="58463" checksum="DF06616EB200E8EC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMR3</accession>
    <name>Q6FMR3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable metalloreductase AIM14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NOX1</name>
        <name evidence="19 20" type="ordered locus">CAGL0K05863g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Probable cell surface metalloreductase. May be involved in iron or copper homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ferric reductase (FRE) family. AIM14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448481.1">
        <property type="nucleotide sequence ID" value="XM_448481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMR3"/>
    <dbReference type="FunCoup" id="Q6FMR3">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMR3"/>
    <dbReference type="KEGG" id="cgr:2890474"/>
    <dbReference type="CGD" id="CAL0133993">
        <property type="gene designation" value="NOX1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05863g"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036508_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMR3"/>
    <dbReference type="OMA" id="GRMAYCL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044068">
        <property type="term" value="P:symbiont-mediated perturbation of host cellular process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF198">
        <property type="entry name" value="METALLOREDUCTASE AIM14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00463">
        <property type="entry name" value="AIM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="16">
        <location>
            <begin position="107"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding 8" evidence="17">
        <location>
            <begin position="270"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric reductase NAD binding" evidence="18">
        <location>
            <begin position="369"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0133993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG61442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="532" mass="60733" checksum="BA9A4B3D83465C53" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMS9</accession>
    <name>Q6FMS9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0K05511g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMS9"/>
    <dbReference type="STRING" id="284593.Q6FMS9"/>
    <dbReference type="KEGG" id="cgr:2890489"/>
    <dbReference type="CGD" id="CAL0133821">
        <property type="gene designation" value="CAGL0K05511g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05511g"/>
    <dbReference type="eggNOG" id="KOG0458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374747_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMS9"/>
    <dbReference type="OMA" id="NTEIANH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="289"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0133821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG61426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="727" mass="82668" checksum="4338046E08BA398F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMX1</accession>
    <name>SPT4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Transcription elongation factor SPT4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Chromatin elongation factor SPT4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SPT4</name>
        <name type="ordered locus">CAGL0K04543g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
        <text evidence="1">Centromere and heterochromatin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448423.1">
        <property type="nucleotide sequence ID" value="XM_448423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMX1"/>
    <dbReference type="SMR" id="Q6FMX1"/>
    <dbReference type="FunCoup" id="Q6FMX1">
        <property type="interactions" value="484"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMX1"/>
    <dbReference type="EnsemblFungi" id="CAGL0K04543g-T">
        <property type="protein sequence ID" value="CAGL0K04543g-T-p1"/>
        <property type="gene ID" value="CAGL0K04543g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890002"/>
    <dbReference type="KEGG" id="cgr:2890002"/>
    <dbReference type="CGD" id="CAL0134725">
        <property type="gene designation" value="CAGL0K04543g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K04543g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04543g"/>
    <dbReference type="eggNOG" id="KOG3490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138052_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FMX1"/>
    <dbReference type="OMA" id="FDGMIAV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001208">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase I"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001209">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase I"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000232">
        <property type="term" value="P:regulation of rRNA processing"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090262">
        <property type="term" value="P:regulation of transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000003">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000238548" description="Transcription elongation factor SPT4">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="102" mass="11084" checksum="C47FDA88759467DB" modified="2004-07-19" version="1">MSSERACMLCGIVQTTNEFGRVGCPNCQGIFEEAGVSTMECTSPSFEGLVGMCKPTKSWVAKWLSVDANIPGMYAVKVDGRLPPEVVELLPHYKPRDGSQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMY9</accession>
    <name>Q6FMY9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ORM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0K04147g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMY9"/>
    <dbReference type="FunCoup" id="Q6FMY9">
        <property type="interactions" value="484"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMY9"/>
    <dbReference type="KEGG" id="cgr:2890045"/>
    <dbReference type="CGD" id="CAL0133973">
        <property type="gene designation" value="CAGL0K04147g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04147g"/>
    <dbReference type="eggNOG" id="KOG3319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072117_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FMY9"/>
    <dbReference type="OMA" id="STHYTHF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090156">
        <property type="term" value="P:intracellular sphingolipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090155">
        <property type="term" value="P:negative regulation of sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0133973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24533" checksum="9A441662BA657584" modified="2004-07-19" version="1">MSDYKPFPAYQGNSNVSAQGSRLRSSSQVSTGASDPVKDHRRKRSSSIISHVEQETFEDDVDQQLLPNMNASWVNQRGAWIIHIVVIVLLKMFYNILPGITAEWSWTLTNMTYIIGFYIMFHLVKGTPFEFNGGAFDNLTMWEQIDHETLFTPSRKFLLAVPIALFLVSTHYAHYDLNLFLWNLAVTIFVGVVPKLAWAHRLRISIPGVMRAQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMZ1</accession>
    <name>Q6FMZ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K04103g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMZ1"/>
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        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMZ1"/>
    <dbReference type="KEGG" id="cgr:2890043"/>
    <dbReference type="CGD" id="CAL0133777">
        <property type="gene designation" value="CAGL0K04103g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04103g"/>
    <dbReference type="eggNOG" id="KOG3146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074922_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FMZ1"/>
    <dbReference type="OMA" id="VYATLIW"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF59">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="55"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0133777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="234" mass="27045" checksum="7F2F8046229B679A" modified="2004-07-19" version="1">MNATTHRNIIPFDDTYILYDPDDVLSFLSAYFSLLPILILTFYLSWFIITRELESCIIALGQLCNEIMNNIVKNIIKQDRPYWVGDSFQENSIRSGYGMPSAHSQFMGFTLSYFTLSLLVAPLSTNRKRSRFEAVSLFLILVVLSACVTFSRVYLHYHSVEQVLVGFTLGLFNGSAYLLVVRVIRSLGLWNWLLSWPIARILYMKDNFNLAPVTLKQEYESFWKTISSKSQKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNM1</accession>
    <name>Q6FNM1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI19</fullName>
            <ecNumber evidence="7">2.4.1.198</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0J10604g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57265"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.198"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the phosphatidylinositol N-acetylglucosaminyltransferase (GPI-GlcNAc transferase) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GPI19 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="7"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNM1"/>
    <dbReference type="FunCoup" id="Q6FNM1">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNM1"/>
    <dbReference type="KEGG" id="cgr:2889611"/>
    <dbReference type="CGD" id="CAL0133180">
        <property type="gene designation" value="CAGL0J10604g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10604g"/>
    <dbReference type="eggNOG" id="KOG2257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081616_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FNM1"/>
    <dbReference type="OMA" id="RYWIICI"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016542">
        <property type="entry name" value="PIG-P_GPI19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008765">
        <property type="entry name" value="PIG-P_GPI19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="9">
        <location>
            <begin position="5"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR008765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0133180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="147" mass="17454" checksum="F7EF2BB1AE2355C6" modified="2004-07-19" version="1">MNYRREYYWFSQYVLVTFTLFFAIFWTLLPKVNENDDWVYGFIPASFVRSIGEIIPQRGWIIYFECFLLMGMLCTYIGLQFFNEDILTPPIDDLRTITDSNANIIVTDANDDFIRNYAFKESSGIVDLPIMDVCNILYKENYMGEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNR5</accession>
    <name>Q6FNR5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0J09658g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNR5"/>
    <dbReference type="FunCoup" id="Q6FNR5">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNR5"/>
    <dbReference type="KEGG" id="cgr:2889717"/>
    <dbReference type="CGD" id="CAL0133020">
        <property type="gene designation" value="CAGL0J09658g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09658g"/>
    <dbReference type="eggNOG" id="KOG2399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004979_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FNR5"/>
    <dbReference type="OMA" id="GWVRMTL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="654"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="693"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="726"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="40"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="581"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0133020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="748" mass="84215" checksum="55A76B56E8FEE5DC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNS4</accession>
    <name>Q6FNS4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0J09460g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448120.1">
        <property type="nucleotide sequence ID" value="XM_448120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNS4"/>
    <dbReference type="FunCoup" id="Q6FNS4">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNS4"/>
    <dbReference type="KEGG" id="cgr:2889933"/>
    <dbReference type="CGD" id="CAL0132784">
        <property type="gene designation" value="CAGL0J09460g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09460g"/>
    <dbReference type="eggNOG" id="KOG4400">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049076_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FNS4"/>
    <dbReference type="OMA" id="NNQDRHQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043633">
        <property type="term" value="P:polyadenylation-dependent RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016713">
        <property type="entry name" value="Air1/2_Saccharomycetales"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049024">
        <property type="entry name" value="AIR2-like_ZnK4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21759">
        <property type="entry name" value="AIR2-like_ZnK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018162">
        <property type="entry name" value="PolyA_pol_Air1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0132784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="344" mass="40195" checksum="99E6E270886760D6" modified="2004-07-19" version="1">MTSLSEVETMDTLPFVKDTTPMSNDDIKVVAPSIEQVGNDPNELRFLRGEGRYFGLDDSEGIKEPEPKCRNCSQRGHFKRDCPHVICTFCGSMDDHYSQHCPKAIKCANCNKVGHYRSQCPNKWKRVFCTLCNSKLHDRDRCPSLWRSYLLREELTGKGNKKKLDLDTDAIYCYNCGGNGHFGDDCNQRRSSRVPKDDGSAFAGNNLRDELRTKYYKKLDQERGKKGRKNNSKVKGNHKRFDDNNNFNYDDYEYDDSIYDEWDNSQLDRKYSGSTKKKNTNKKQKKNNNSHRDPLEFPRSKRNDFNDNSKRGNFSRNDDKAKAKNMRWNNSKKNRKSYRSTERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNW4</accession>
    <name>Q6FNW4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0J08569g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNW4"/>
    <dbReference type="FunCoup" id="Q6FNW4">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNW4"/>
    <dbReference type="KEGG" id="cgr:2889713"/>
    <dbReference type="CGD" id="CAL0133558">
        <property type="gene designation" value="CAGL0J08569g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08569g"/>
    <dbReference type="eggNOG" id="KOG2603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052855_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FNW4"/>
    <dbReference type="OMA" id="VLFGMYS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273380" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3" evidence="10">
        <location>
            <begin position="23"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0133558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39120" checksum="530FC7872EF61CFC" modified="2004-07-19" version="1">MQMFNFSRLVALLLVLVNVSLALSPKQFNKERLKYKDSIIDLNDRNWGRLLANPKESYLVTVFTATGRQYGCTMCTELAEHYETVVRSWFADHPDGISKNDGSKSLFFAKVDAVDQNVPELFQKFNVEQVPRIIIYEPGKGDPQYKFLDIQLSGENVVETLIAGIKESTDVQDFEIHEEINWSSVTITGVATFATVLLVKKQSTLALKIFTSRYVWGFGTIFFIIAMLGGHMFNRIRNTPEAGMDKLKNVIYILPGQISGQYAIETQIVGLLYAVLCALIVALVMVVPNVSKKLSGPENAKETAQVIVTILTAVFIYMFFAAFTKVFEVKYTGYPYTLLKLFNFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPC4</accession>
    <name>Q6FPC4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase DOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0J04928g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPC4"/>
    <dbReference type="FunCoup" id="Q6FPC4">
        <property type="interactions" value="1296"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPC4"/>
    <dbReference type="KEGG" id="cgr:2889562"/>
    <dbReference type="CGD" id="CAL0133484">
        <property type="gene designation" value="CAGL0J04928g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04928g"/>
    <dbReference type="eggNOG" id="KOG0948">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FPC4"/>
    <dbReference type="OMA" id="IMLKNYN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004532">
        <property type="term" value="F:RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000292">
        <property type="term" value="P:RNA fragment catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140746">
        <property type="term" value="P:siRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000002">
        <property type="entry name" value="superkiller viralicidic activity 2-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="Prismane protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="150"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="385"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0133484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1065" mass="120790" checksum="B4D3553A9B02774E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPP8</accession>
    <name>Q6FPP8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0J02090g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPP8"/>
    <dbReference type="FunCoup" id="Q6FPP8">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPP8"/>
    <dbReference type="KEGG" id="cgr:2889787"/>
    <dbReference type="CGD" id="CAL0132938">
        <property type="gene designation" value="CAGL0J02090g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02090g"/>
    <dbReference type="eggNOG" id="KOG3385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086133_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FPP8"/>
    <dbReference type="OMA" id="FFWVWIT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000089">
        <property type="entry name" value="Golgi vesicular membrane trafficking protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="49"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0132938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="139" mass="16251" checksum="76D49FFC12BB31C4" modified="2004-07-19" version="1">MSSEYAESTLYQRDPSRTQLFGAADPTLIDDRTSPYDKGKLDYSQSTLAHLESQSEEQMGVMTEKIRALKSLSMRMGDEIRGSNKTLDQLDDTFQRTTVKLKQTFNNMMDMAKRSRISIKTWLLLFFFIFLLFFYVWIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPU4</accession>
    <name>Q6FPU4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0J00869g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPU4"/>
    <dbReference type="FunCoup" id="Q6FPU4">
        <property type="interactions" value="762"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPU4"/>
    <dbReference type="KEGG" id="cgr:2889871"/>
    <dbReference type="CGD" id="CAL0133410">
        <property type="gene designation" value="CAGL0J00869g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J00869g"/>
    <dbReference type="eggNOG" id="KOG3297">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073901_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FPU4"/>
    <dbReference type="OMA" id="LGPTLWW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004519">
        <property type="entry name" value="RNAP_E/RPC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00448">
        <property type="entry name" value="rpoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="9">
        <location>
            <begin position="83"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0133410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="216" mass="24938" checksum="C8101131D23E83E0" modified="2004-07-19" version="1">MFILTKLKDLVRIPPDQFHRDAVSAITHELNVKYSNKVVPHVGLSVSVYDLLEVDEGQLRPGDGASYINVTFRCVVFKPFAGEILTGWIKRCDGEGIQVSMMGLFDDIFIPKKMLFEGSYYSPEDGAWVWPMDEETKLYLDVNEMIRFRVEEEVFVDVKPPSPKELELERERELQLQEQQEHQQHQQQESKLEKPPAYALLGSCQTDGMGLVSWWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQF5</accession>
    <name>Q6FQF5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PEA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I06666g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQF5"/>
    <dbReference type="FunCoup" id="Q6FQF5">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQF5"/>
    <dbReference type="KEGG" id="cgr:2889081"/>
    <dbReference type="CGD" id="CAL0132096">
        <property type="gene designation" value="CAGL0I06666g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06666g"/>
    <dbReference type="eggNOG" id="ENOG502QTTD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054089_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQF5"/>
    <dbReference type="OMA" id="IMRNEFK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000133">
        <property type="term" value="C:polarisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007121">
        <property type="term" value="P:bipolar cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000753">
        <property type="term" value="P:cell morphogenesis involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071468">
        <property type="term" value="P:cellular response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="51542" checksum="C4BB358A6BD2E221" modified="2004-07-19" version="1">MYDMDLLRRANPVLFSPERYDEYPLGYDDLMQYLSTKDITSQSDPQHNRPYTYIDSLDFLLYSQDEDEIDIDLDKKLACEYALYYAQSKKRQNKHKRMSLLGSRKYLDDLLYGGANHSRDWYEAVITMLENLSITELDPDTVGKLERLVKTNKSGVNVSMLSHNMNGFQKPEFPRSRKQSGSGLDLMRDNNGSHSEVFSGHTLNESDDTMEEESQGIIQDLISYLISNSIKRGINVKPTNLNNPVEFLKGAIDEILDAKTDSLDNKPQDRSSNIDTLETSVTPVNFHEADTNELKTALNDLQLAHSFLTKQFETSRLEQSQTINRLTKTNRELQDKLLKYHAKISKLEEKLKVTEDAKTQLEDAAHKINMKENLLLSSPIMAPELFSPSTPTSGLNSSPSNNNSHSITVMRNEFKRMILETQDKYEKELAEEREKRLKLEKEFEELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQJ7</accession>
    <name>Q6FQJ7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">6-phosphofructokinase</fullName>
            <ecNumber evidence="4 15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">CAGL0I05698g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="4 15"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQJ7"/>
    <dbReference type="STRING" id="284593.Q6FQJ7"/>
    <dbReference type="KEGG" id="cgr:2889342"/>
    <dbReference type="eggNOG" id="KOG2440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011053_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQJ7"/>
    <dbReference type="OMA" id="CIATRES"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="197"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="16">
        <location>
            <begin position="584"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG60434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="957" mass="105268" checksum="D8063D838A39D772" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQU9</accession>
    <name>Q6FQU9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0I03388g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQU9"/>
    <dbReference type="FunCoup" id="Q6FQU9">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQU9"/>
    <dbReference type="KEGG" id="cgr:2889174"/>
    <dbReference type="CGD" id="CAL0132224">
        <property type="gene designation" value="CAGL0I03388g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03388g"/>
    <dbReference type="eggNOG" id="KOG2151">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033275_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FQU9"/>
    <dbReference type="OMA" id="IFYMKPR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000749">
        <property type="term" value="P:response to pheromone triggering conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="4">
        <location>
            <begin position="55"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0132224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="191" mass="22430" checksum="C393B0CAC0D8DA80" modified="2004-07-19" version="1">MSKFGLQKLVPLIRADEEKDGKVYDHSMTIGTDLSSMLHSLGIPRDSKHHRVLDTFQSPWAETSRSEVEPKYYIPESFKNIPDVLQSKTTPPTFDDVQTDQQRVALFQDETLFYLFYKHPGTVIQELTYLELRKRNWRYHKGLKAWLTKDPMMEPVVAADGLSERGSYVFFDPQRWEKCQRDFPLFYSAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR98</accession>
    <name>Q6FR98_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0H10318g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR98"/>
    <dbReference type="FunCoup" id="Q6FR98">
        <property type="interactions" value="1167"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR98"/>
    <dbReference type="KEGG" id="cgr:2888435"/>
    <dbReference type="CGD" id="CAL0131720">
        <property type="gene designation" value="CAGL0H10318g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10318g"/>
    <dbReference type="eggNOG" id="KOG0659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q6FR98"/>
    <dbReference type="OMA" id="CLESEYF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140836">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat S5 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905866">
        <property type="term" value="P:positive regulation of Atg1/ULK1 kinase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000554">
        <property type="entry name" value="CMGC/CDK/CDK7 protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="6"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0131720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG60179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="307" mass="35179" checksum="3EF47DD970A8E821" modified="2004-07-19" version="1">MERAEYTKEKKVGEGTYAVVYVGTKQSTGRRIAVKEIKTSEFKDGLDMSAIREVKYLQEMQHVNVIELVDIFMSYGNLNLVLEYLPTDLEVVIKDKSILFTPADIKSWMLMSVRGVHHCHRNFILHRDLKPNNLLIAPDGQIKVADFGLARAVPSPHEVLTSNVVTRWYRAPELLFGAKHYTSAIDVWSLGVIFAELMLRIPYLPGQNDLEQMEVTFRALGTPTDKDWPEVSSFNSYNKLQMYPPPSRDELRKRFIAATENALNFMNGMMCLNPAKRWSTAQCLESEYFKELPRPSDPATIDITRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRI5</accession>
    <name>Q6FRI5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">10 kDa heat shock protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HSP10</name>
        <name evidence="5 6" type="ordered locus">CAGL0H08283g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447159.1">
        <property type="nucleotide sequence ID" value="XM_447159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRI5"/>
    <dbReference type="SMR" id="Q6FRI5"/>
    <dbReference type="FunCoup" id="Q6FRI5">
        <property type="interactions" value="850"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRI5"/>
    <dbReference type="GeneID" id="2888573"/>
    <dbReference type="KEGG" id="cgr:2888573"/>
    <dbReference type="CGD" id="CAL0130579">
        <property type="gene designation" value="HSP10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08283g"/>
    <dbReference type="eggNOG" id="KOG1641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRI5"/>
    <dbReference type="OMA" id="EDFLIMR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0130579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11404" checksum="B17B0263AB64FC09" modified="2004-07-19" version="1">MSTLLKSAKSIVPLMDRVLVQRIKAEAKTASGLFLPEKNVEKLNQAKVVAVGPGFTDANGNKVTPQVSVGDQVLIPQFGGSTLKLANDEEVILFRDSEILAKIKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRP5</accession>
    <name>Q6FRP5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Asparagine synthase (glutamine-hydrolyzing)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0H06963g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447099.1">
        <property type="nucleotide sequence ID" value="XM_447099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRP5"/>
    <dbReference type="FunCoup" id="Q6FRP5">
        <property type="interactions" value="753"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRP5"/>
    <dbReference type="KEGG" id="cgr:2888447"/>
    <dbReference type="CGD" id="CAL0129996">
        <property type="gene designation" value="CAGL0H06963g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06963g"/>
    <dbReference type="eggNOG" id="KOG0573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012368_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FRP5"/>
    <dbReference type="OMA" id="HAKICIL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03766">
        <property type="entry name" value="Gn_AT_II_novel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="5">
        <location>
            <begin position="72"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="252"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="4">
        <location>
            <begin position="412"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0129996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="58580" checksum="FA38611952A4FD59" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRS5</accession>
    <name>Q6FRS5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease III homolog</fullName>
            <ecNumber evidence="8">3.2.2.-</ecNumber>
            <ecNumber evidence="8">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="8">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NTG1</name>
        <name evidence="10 11" type="ordered locus">CAGL0H06303g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="8"/>
    <dbReference type="EC" id="4.2.99.18" evidence="8"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447069.1">
        <property type="nucleotide sequence ID" value="XM_447069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRS5"/>
    <dbReference type="FunCoup" id="Q6FRS5">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRS5"/>
    <dbReference type="GeneID" id="2888786"/>
    <dbReference type="KEGG" id="cgr:2888786"/>
    <dbReference type="CGD" id="CAL0131730">
        <property type="gene designation" value="CAGL0H06303g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06303g"/>
    <dbReference type="eggNOG" id="KOG1921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_4_3_1"/>
    <dbReference type="InParanoid" id="Q6FRS5"/>
    <dbReference type="OMA" id="KLFKWVD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090297">
        <property type="term" value="P:positive regulation of mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="9">
        <location>
            <begin position="179"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for N-glycosylase activity" evidence="8">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0131730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="468" mass="53989" checksum="08ACF1507BC5C38E" modified="2004-07-19" version="1">MLRSTSRFRPRSTLGVIQWHTMAVLRKRKSSAKEIAVKNENSEVTKSKYFKERVKVKKEREVDISHDRDYVDINWVKSLDSENYFKWIVSRNGNVPNRWSQPFDDTIFTDLDEESFKLLPKNFPEIYKKMRWMRSFIRAPVDLIGGSSIPMTVGEICGIKKSEILPRNYRLQVLVGVMLSAQTKDEVTAMGMYNIMKYCIEELKDAQGITLDALLRIDEQVLDELIHSVGFHKRKANFIKRTAAILNEKYDQDVPDNVTDILGLPGVGPKMGYLTLQKAWGKIEGICVDVHVDRLCKMWKWVDPDKCKTPNDTRKQLQKWLPPRLWTEINGLLVGFGQVIGKSRGANFNIFRVNIDESKQRQLTEKTFTTLSNLNESIRSNITSYSKWMGFLMKLDLKKLENDMKEELDVSIVEGEQNSIELKKEPHSSIDNKLDVGVKLEESCAINVDTSLKSEILIKKEPDTSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRU0</accession>
    <name>Q6FRU0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0H05929g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRU0"/>
    <dbReference type="FunCoup" id="Q6FRU0">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRU0"/>
    <dbReference type="KEGG" id="cgr:2888667"/>
    <dbReference type="CGD" id="CAL0130506">
        <property type="gene designation" value="CAGL0H05929g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05929g"/>
    <dbReference type="eggNOG" id="KOG1862">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019270_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRU0"/>
    <dbReference type="OMA" id="RQEFLRW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="248"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="804"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0130506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="955" mass="106881" checksum="8A20AEA193FE1230" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRU3</accession>
    <name>Q6FRU3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0H05863g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRU3"/>
    <dbReference type="FunCoup" id="Q6FRU3">
        <property type="interactions" value="904"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRU3"/>
    <dbReference type="KEGG" id="cgr:2888622"/>
    <dbReference type="CGD" id="CAL0130295">
        <property type="gene designation" value="CAGL0H05863g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05863g"/>
    <dbReference type="eggNOG" id="KOG3949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040685_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRU3"/>
    <dbReference type="OMA" id="QGMLKVH"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="430"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="441"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0130295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="466" mass="51730" checksum="A0861BF80DA8325B" modified="2004-07-19" version="1">MSFRKRGEVLAGGRLPNRAPLVPGRTPGGTPSTPGDAGVNRLSGRMEQLNLRGGVRANISGRPLADGRTAASGPNKEPISAFGVNHPGIRPSPASSQPATSTGCFDLDKVLGHMGLPLGTSLLIEERNFTEFNSVLVKLMCSQGIIHNRVEDNKEKNGNTHLIILSASQSLGKELPGVYKGSKKDIKKSKISEEQKKLSVQNLNEEKSTPSRYKDLKIAWKYKFVDEQRGVKNAEAGDSLSSEYPNYNHQFDITSRLLPAPTSNELTFINPTEPVASIINKLDRTIQQHSNKLIRIVIPSLLHPATYPPRMFLSSEVLLLMHGLRGILKKYSSRCVLMGTISTDIIDSFLLAQLENFFDSVLNLEPFGQDMMQFLERIYKTQPGKIQQGLLHIMKLPVFSERGEMHVMKSELAFKNGRKKFEIEEWGIPVDDVEDDKPEKQNNPNETDMSNTIAAPKKSTKVSLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRX9</accession>
    <name>Q6FRX9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">leucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0H05049g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="3"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRX9"/>
    <dbReference type="FunCoup" id="Q6FRX9">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRX9"/>
    <dbReference type="KEGG" id="cgr:2888800"/>
    <dbReference type="CGD" id="CAL0131750">
        <property type="gene designation" value="CAGL0H05049g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05049g"/>
    <dbReference type="eggNOG" id="KOG0435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRX9"/>
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    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial matrix"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
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        <property type="term" value="F:pre-mRNA intronic binding"/>
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        <property type="term" value="P:Group I intron splicing"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mitochondrial translation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mRNA processing"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000002">
        <property type="entry name" value="Leucine--tRNA ligase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Leucine--tRNA ligase"/>
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    </dbReference>
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        <property type="entry name" value="probable leucine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
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    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740:SF2">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="71"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Leucyl-tRNA synthetase editing" evidence="14">
        <location>
            <begin position="258"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="456"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0131750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG59948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="907" mass="103940" checksum="CC06C7BB3A896926" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS46</accession>
    <name>Q6FS46_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0H03553g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference evidence="16 17 18" key="2">
        <citation type="journal article" date="2016" name="EMBO J." volume="35" first="2139" last="2151">
            <title>Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator.</title>
            <authorList>
                <person name="Ye Q."/>
                <person name="Ur S.N."/>
                <person name="Su T.Y."/>
                <person name="Corbett K.D."/>
            </authorList>
            <dbReference type="PubMed" id="27491543"/>
            <dbReference type="DOI" id="10.15252/embj.201694082"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 1-403</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="4XH0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.99 A"/>
        <property type="chains" value="A=1-403"/>
    </dbReference>
    <dbReference type="PDB" id="4XHG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="A=1-403"/>
    </dbReference>
    <dbReference type="PDB" id="4XHH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.91 A"/>
        <property type="chains" value="A=1-403"/>
    </dbReference>
    <dbReference type="PDBsum" id="4XH0"/>
    <dbReference type="PDBsum" id="4XHG"/>
    <dbReference type="PDBsum" id="4XHH"/>
    <dbReference type="AlphaFoldDB" id="Q6FS46"/>
    <dbReference type="SMR" id="Q6FS46"/>
    <dbReference type="FunCoup" id="Q6FS46">
        <property type="interactions" value="1199"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS46"/>
    <dbReference type="KEGG" id="cgr:2888610"/>
    <dbReference type="CGD" id="CAL0130244">
        <property type="gene designation" value="CAGL0H03553g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03553g"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_2_7_1"/>
    <dbReference type="InParanoid" id="Q6FS46"/>
    <dbReference type="OMA" id="ESRVYKY"/>
    <dbReference type="EvolutionaryTrace" id="Q6FS46"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000370">
        <property type="term" value="P:positive regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000785">
        <property type="term" value="P:regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001159">
        <property type="term" value="P:regulation of protein localization by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106214">
        <property type="term" value="P:regulation of vesicle fusion with Golgi apparatus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000635">
        <property type="entry name" value="Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16 17 18" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="427"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0130244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="4XH0"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="4XHG"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="4XHH"/>
        </source>
    </evidence>
    <sequence length="495" mass="57174" checksum="0ECCBAF963238F77" modified="2004-07-19" version="1">MDLRVGRKFRIGRKIGSGSFGDIYHGTNLISGEEVAIKLESIRSRHPQLDYESRVYKYLSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCISVETLCAGLPLEFSEYMNYCRNLKFDERPDYLYLARLFKDLSIKLEYHNDHLFDWTMLRYTKAMVEKQKDVLMLDTSSTANANKESGNNNNESNTTSNTKDSKNDSFNKVKLLAMKKFASHFHYCKNDDKHYPTPEEIKQQTVQNNNAAASLPPELLSAIDKGMENLKQQQNQQQQQSQQVQMQPLASAELNQDQLPPQGPEPLLQRQRKETQGQFVPTQEPVNRATHYPPNVQTNNMPQVQQQNISPQNPKPSGDNIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSH1</accession>
    <name>Q6FSH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0H00572g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSH1"/>
    <dbReference type="FunCoup" id="Q6FSH1">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888682"/>
    <dbReference type="CGD" id="CAL0131958">
        <property type="gene designation" value="CAGL0H00572g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00572g"/>
    <dbReference type="eggNOG" id="KOG4561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034597_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FSH1"/>
    <dbReference type="OMA" id="MPVYYSH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="71"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0131958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="282" mass="32507" checksum="40EB0FDEBD240999" modified="2004-07-19" version="1">MSSLNDTVAAGYYEPLFGLSWYPDRLDNLWLAHLHEIVYAFIFYQVCQYTIAPKINRYFFGKHYSDITDKKLKLDFDVHTVSMIQAVISIAILLPVLALPFDLNIATYVNPWCSMVSALSCGYFVWDLALCLRHFSIYGFEFLFHAVGSLVVMLAILTPFCQPWVGKYLLFEASTPFVNMNWYTIQLNHKHKSSSGPVIPNWLNMINGLLLLLTFFGVRIVWGWSCNLLLLRQFWRARYELPYLAGAVVLSLNITMSLLNVLWFSKMLKIAKKMASPSKKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSH4</accession>
    <name>Q6FSH4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP synthase subunit beta</fullName>
            <ecNumber evidence="15">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ATP2</name>
        <name evidence="17 18" type="ordered locus">CAGL0H00506g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="15"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446820.1">
        <property type="nucleotide sequence ID" value="XM_446820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSH4"/>
    <dbReference type="SMR" id="Q6FSH4"/>
    <dbReference type="FunCoup" id="Q6FSH4">
        <property type="interactions" value="1363"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSH4"/>
    <dbReference type="GeneID" id="2888587"/>
    <dbReference type="KEGG" id="cgr:2888587"/>
    <dbReference type="CGD" id="CAL0131710">
        <property type="gene designation" value="ATP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00506g"/>
    <dbReference type="eggNOG" id="KOG1350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FSH4"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 15" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="178"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0131710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG59751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="507" mass="54209" checksum="1D6699BF58EA2E68" modified="2004-07-19" version="1">MVLPRLYAAPSSRAALQAARMASKFNSPVRFASTAALASGKVSAVIGAIVDVQFEESNLPAILNALEIKTPQGKLVLEVAQHLGENTVRTIAMDGTEGLVRGEKVVDTGAPISVPVGRETLGRIINVIGEPIDERGPINSKLRKPIHADPPSFAEQSTAAEVLETGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGFSVFTGVGERTREGNDLYREMKETGVINLEGDSKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGLLQERITTTKKGSVTSVQAVYVPADDLTDPAPATTFAHLDATTVLSRSISELGIYPAVDPLDSKSRLLDAAVVGEEHYNVATKVQETLQTYKSLQDIIAILGMDELSEQDKLTVERARKIQRFLSQPFAVAEVFTGIEGKLVRLKDTISSFKAVLEGKYDDLPENAFYMVGGIEDVVAKAEKLAAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSN4</accession>
    <name>Q6FSN4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">AP-3 complex subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0G09174g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 3 (AP-3) is a heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSN4"/>
    <dbReference type="FunCoup" id="Q6FSN4">
        <property type="interactions" value="674"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSN4"/>
    <dbReference type="KEGG" id="cgr:2888045"/>
    <dbReference type="CGD" id="CAL0137649">
        <property type="gene designation" value="CAGL0G09174g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09174g"/>
    <dbReference type="eggNOG" id="KOG1059">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001908_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FSN4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000251">
        <property type="entry name" value="AP-3 complex subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017105">
        <property type="entry name" value="AP3_complex_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781:SF12">
        <property type="entry name" value="AP-3 COMPLEX SUBUNIT DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22781">
        <property type="entry name" value="DELTA ADAPTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037092">
        <property type="entry name" value="AP3_complex_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="11">
        <location>
            <begin position="46"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="882"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="893"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0137649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="920" mass="104243" checksum="E89F0F1F0E2215A2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSX4</accession>
    <name>Q6FSX4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="7">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">APT1</name>
        <name evidence="13 14" type="ordered locus">CAGL0G07106g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="7"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446670.1">
        <property type="nucleotide sequence ID" value="XM_446670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSX4"/>
    <dbReference type="FunCoup" id="Q6FSX4">
        <property type="interactions" value="596"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSX4"/>
    <dbReference type="GeneID" id="2888030"/>
    <dbReference type="KEGG" id="cgr:2888030"/>
    <dbReference type="CGD" id="CAL0130544">
        <property type="gene designation" value="APT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07106g"/>
    <dbReference type="eggNOG" id="KOG1712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FSX4"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000004">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="12">
        <location>
            <begin position="36"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0130544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="190" mass="20981" checksum="28B15B3E18451464" modified="2004-07-19" version="1">MSIESYAKDLKAALHQYPNFPSEGILFEDFLPIFREPQLFQKLVDAFKMHLEETFTEKKVDYIVGLESRGFLFGPSLALAMGIGFVPVRKAGKLPGECVKAVYEKEYGSDEFEMQKHAIPAGANVVIVDDIIATGGSAGAAEELIKKIGANVLEYDFVMELDFLKGRDKLNAPVFTLLSSQKEALQKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSZ9</accession>
    <name>Q6FSZ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PHO23</name>
        <name evidence="14 15" type="ordered locus">CAGL0G06556g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446645.1">
        <property type="nucleotide sequence ID" value="XM_446645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSZ9"/>
    <dbReference type="FunCoup" id="Q6FSZ9">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSZ9"/>
    <dbReference type="GeneID" id="2888221"/>
    <dbReference type="KEGG" id="cgr:2888221"/>
    <dbReference type="CGD" id="CAL0129277">
        <property type="gene designation" value="PHO23"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06556g"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031900_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FSZ9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016479">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase I"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000219">
        <property type="term" value="P:positive regulation of invasive growth in response to glucose limitation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000016">
        <property type="entry name" value="Inhibitor of growth protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="264"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="145"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0129277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG59572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="316" mass="35697" checksum="29E2D61D077C7154" modified="2004-07-19" version="1">MSSPANLFPGLNDIVDVLEELPLEISRYFTLLHEIDAKCVLAGPALDDKIKGFLENDPTEKQDEIAQKDKLQSLVSINQFLEELMPSFEEKMHVSSIMLESLQRLTSRMELAYEVAIKNEEIPYSLRLGVDNHPAMHLHHELMQKVDHKANSKSSQAQKSESRREAMAANRRTDPQQHQSTNNNNNSANEKSNSVPAHSDNANTNNRKRANNDKNSANGNGHSNNDNKKRKRKVTTTTTPLGSHPKSSGNIRSPRPKTNEYGEPLYCYCNQVAYGEMVGCDGEDCELEWFHLPCIGFETIPKGKWYCEDCKKKLAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT37</accession>
    <name>TIM22_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TIM22</name>
        <name type="ordered locus">CAGL0G05654g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the TIM22 complex, whose core is composed of TIM22 and TIM54, associated with the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446607.1">
        <property type="nucleotide sequence ID" value="XM_446607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT37"/>
    <dbReference type="SMR" id="Q6FT37"/>
    <dbReference type="FunCoup" id="Q6FT37">
        <property type="interactions" value="702"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT37"/>
    <dbReference type="EnsemblFungi" id="CAGL0G05654g-T">
        <property type="protein sequence ID" value="CAGL0G05654g-T-p1"/>
        <property type="gene ID" value="CAGL0G05654g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888408"/>
    <dbReference type="KEGG" id="cgr:2888408"/>
    <dbReference type="CGD" id="CAL0130616">
        <property type="gene designation" value="CAGL0G05654g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_G05654g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05654g"/>
    <dbReference type="eggNOG" id="KOG3225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091077_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FT37"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000228088" description="Mitochondrial import inner membrane translocase subunit TIM22">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="42"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="A0A1D8PI78"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q12328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="193" mass="20242" checksum="71FA91A98E6401BD" modified="2004-07-19" version="1">MVYRGFGLEYLSPPEKKAFGELSPDEQGERGAEMVVGFMSSCPGKSVISGATGFALGGVLGLFMASMAYDTPLHTPVPGGMSGAVQQMADLPLRQQVKLQFADMGKRAYSSAKNFGYIGMIYAGVECAVESLRAKNDIYNGITAGCITGGGLAYKSGPQAALVGCAGFAAFSAAIDMYMKSEDGRPPENDFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTG0</accession>
    <name>Q6FTG0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G02783g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHQ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTG0"/>
    <dbReference type="FunCoup" id="Q6FTG0">
        <property type="interactions" value="835"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTG0"/>
    <dbReference type="KEGG" id="cgr:2888335"/>
    <dbReference type="CGD" id="CAL0130342">
        <property type="gene designation" value="CAGL0G02783g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02783g"/>
    <dbReference type="eggNOG" id="KOG3247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030217_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTG0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039742">
        <property type="entry name" value="Shq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048696">
        <property type="entry name" value="SHQ1-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007009">
        <property type="entry name" value="Shq1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12967:SF0">
        <property type="entry name" value="PROTEIN SHQ1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04925">
        <property type="entry name" value="SHQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21413">
        <property type="entry name" value="SHQ1-like_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0130342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="490" mass="57164" checksum="B4A20684FD9981FB" modified="2004-07-19" version="1">MITPKFEVSQDDDFVYVNIKITNIRFNSGGLEVVVDKTMLFFYLSPYYLRLRFPNEVLDDDDHPTEAQYRSKDECIFIKLPKAVKGQYFDDLDIPTKLLARQGDIIGADMVEKSTEIKKGPLIQEIDSTTNTEKNVENITQMGEQFDWEIKQNVSSEPTLSLNKYGFDAQYNGLIGVSIPNGNDINELNDPENTTENDRIKERLSKENLKFDPDYYVSEYMVSKYGSEEDLEVNGIKKLLGFTPRIVKDFLGWYKSIEDKESFYPVEFTEFEQNQMVNNIPKKEYLVNEIDHIKKLYLTIVNVVFAYIYDSIENEDASNSESAWNIGKLTPQIAFLDQKLQLEEVEGVSIIKVLIYTGFRRALSYPLHRNYDLCNKAWEYTYYILRGGKKLVLRALLKVHEIFRFHDAYYVYNKILLDDLVSWFINNGNENVLRGLTMEFKKELDTISKETIDFDCLVELDQETGEPVWENMTIKEMEILAEAEYQSTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTH1</accession>
    <name>Q6FTH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G02541g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446473.1">
        <property type="nucleotide sequence ID" value="XM_446473.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FTH1">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTH1"/>
    <dbReference type="KEGG" id="cgr:2888019"/>
    <dbReference type="CGD" id="CAL0137677">
        <property type="gene designation" value="CAGL0G02541g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02541g"/>
    <dbReference type="eggNOG" id="ENOG502QQKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006407_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTH1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1295" mass="148573" checksum="DDF7D32A53B421C0" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUC1</accession>
    <name>Q6FUC1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yippee domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0F04631g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUC1"/>
    <dbReference type="FunCoup" id="Q6FUC1">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUC1"/>
    <dbReference type="KEGG" id="cgr:2887590"/>
    <dbReference type="CGD" id="CAL0129308">
        <property type="gene designation" value="CAGL0F04631g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04631g"/>
    <dbReference type="eggNOG" id="KOG3399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043857_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FUC1"/>
    <dbReference type="OMA" id="ALMCKAP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="4">
        <location>
            <begin position="74"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0129308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="171" mass="19561" checksum="D17632167DAE88A5" modified="2004-07-19" version="1">MGLRYTSYIESPLASDLNKSFKGSRNSQTDLYQYNEYGTIGNSLYSGPILLRQRRRTLSGSSDSSSSSQEKIFVTYGCRRCRTHLSSSSHVISKDYRGKTGTAYLMDEVLNVLEGNVETRPMLTGDYVVCDILCHWCKNVVGWKYLQSERKDQRYKEGKFILEVKTICKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUH1</accession>
    <name>Q6FUH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mRNA export factor MEX67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0F03531g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the export of mRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NXF family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUH1"/>
    <dbReference type="FunCoup" id="Q6FUH1">
        <property type="interactions" value="576"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUH1"/>
    <dbReference type="KEGG" id="cgr:2887899"/>
    <dbReference type="CGD" id="CAL0129517">
        <property type="gene designation" value="CAGL0F03531g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03531g"/>
    <dbReference type="eggNOG" id="KOG3763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024991_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FUH1"/>
    <dbReference type="OMA" id="KLEWAPW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042272">
        <property type="term" value="C:nuclear RNA export factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14342">
        <property type="entry name" value="UBA_TAP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000296">
        <property type="entry name" value="mRNA export factor MEX67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040736">
        <property type="entry name" value="Mex67_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057125">
        <property type="entry name" value="NXF1/2/3/5-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030217">
        <property type="entry name" value="NXF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005637">
        <property type="entry name" value="TAP_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10662:SF22">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24048">
        <property type="entry name" value="LRR_NXF1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22602">
        <property type="entry name" value="NXF_NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18444">
        <property type="entry name" value="RRM_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03943">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00804">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51281">
        <property type="entry name" value="TAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="12">
        <location>
            <begin position="277"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="TAP-C" evidence="13">
        <location>
            <begin position="537"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0129517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG59047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="590" mass="66405" checksum="BB4277133F19239D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUJ3</accession>
    <name>Q6FUJ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0F03025g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUJ3"/>
    <dbReference type="FunCoup" id="Q6FUJ3">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUJ3"/>
    <dbReference type="KEGG" id="cgr:2887689"/>
    <dbReference type="CGD" id="CAL0129353">
        <property type="gene designation" value="CAGL0F03025g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03025g"/>
    <dbReference type="eggNOG" id="ENOG502QQTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005663_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUJ3"/>
    <dbReference type="OMA" id="IWAEAST"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="928" mass="104809" checksum="07DB2B53B7D81A96" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUL3</accession>
    <name>Q6FUL3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HPT1</name>
        <name evidence="4 5" type="ordered locus">CAGL0F02563g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446081.1">
        <property type="nucleotide sequence ID" value="XM_446081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUL3"/>
    <dbReference type="FunCoup" id="Q6FUL3">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUL3"/>
    <dbReference type="GeneID" id="2887671"/>
    <dbReference type="KEGG" id="cgr:2887671"/>
    <dbReference type="CGD" id="CAL0131144">
        <property type="gene designation" value="HPT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02563g"/>
    <dbReference type="eggNOG" id="ENOG502QRN9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092544_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUL3"/>
    <dbReference type="OMA" id="IMKTGNY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF1">
        <property type="entry name" value="HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0131144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="215" mass="24572" checksum="66A46BC96613FE62" modified="2004-07-19" version="1">MSDEDKQYISYNNVHQLCQIGAERIKNFKPDLIIAIGGGGFIPARILRTFLKEPGVPTIRIFAIILSLYEDLHTAGSEVEQVGVKVNRTQWIDYEQCKLDLVGKNVLIVDEVDDTRTTLHYALHELEKDAADQAKAKGIDLEKNPEQKTNFGIFVLHDKLKPKKADLPAELLNDPNRYFAARQVPDKWYAYPWESKDIVFHTKMAVQQGNDIFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUM8</accession>
    <name>Q6FUM8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PHM1</name>
        <name evidence="9 10" type="ordered locus">CAGL0F02145g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUM8"/>
    <dbReference type="FunCoup" id="Q6FUM8">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUM8"/>
    <dbReference type="KEGG" id="cgr:2887813"/>
    <dbReference type="CGD" id="CAL0129424">
        <property type="gene designation" value="PHM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02145g"/>
    <dbReference type="eggNOG" id="KOG1161">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009308_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FUM8"/>
    <dbReference type="OMA" id="SFKFWVH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="551"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0129424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="816" mass="94928" checksum="8EF727CB1A11DFCA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUN7</accession>
    <name>Q6FUN7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="11">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IRC15</name>
        <name evidence="14 15" type="ordered locus">CAGL0F01947g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="9 11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="11"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUN7"/>
    <dbReference type="FunCoup" id="Q6FUN7">
        <property type="interactions" value="1197"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUN7"/>
    <dbReference type="KEGG" id="cgr:2887935"/>
    <dbReference type="CGD" id="CAL0129418">
        <property type="gene designation" value="IRC15"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01947g"/>
    <dbReference type="eggNOG" id="KOG1335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FUN7"/>
    <dbReference type="OMA" id="CAQLGMK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042743">
        <property type="term" value="P:hydrogen peroxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006550">
        <property type="term" value="P:L-isoleucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 9 11" id="KW-0274">FAD</keyword>
    <keyword evidence="2 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="13">
        <location>
            <begin position="24"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="12">
        <location>
            <begin position="374"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="472"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="207"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="346"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="61"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0129418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="493" mass="53134" checksum="0BA971EDF9C60D98" modified="2004-07-19" version="1">MFRAVSRRGFSSSSYLAAIKKQHDLVIIGGGPGGYVAAIKAAQLGLDTACIEKRGSLGGTCLNVGCIPSKALLNNSHLYHQIKSDTKNRGIDVKGDVEINVEQFQKAKDTVVKQLTGGVEMLFKKYKVNYYKGVGSFESENSVKVTPVEGIKGTVEDETIIEAKNIIIATGSEVTPFPGIKIDEERIVSSTGALSLKEVPKRLAVIGGGIIGLEMGSVYSRLGSKVTVLEFQPKIGASMDGEVAATSQKFLKKQGFNFKLSTKVVSAERNGDVVDIVVEDTKSGKTENIQADVLLVAVGRRPYIEGLGAEKLGLEVDKRGRLVIDEQFSTKHPHIKVIGDVTFGPMLAHKAEEEGIAAVEYIKKGHGHVNYGNIPSVMYTHPEVAWVGKTEEQLTEEGIKYKVGKFPFIANSRAKTNMETEGFVKILIDAETERMLGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANLAAFDKPINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUY0</accession>
    <name>Q6FUY0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">37S ribosomal protein S22, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0E06314g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUY0"/>
    <dbReference type="FunCoup" id="Q6FUY0">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUY0"/>
    <dbReference type="KEGG" id="cgr:2887346"/>
    <dbReference type="CGD" id="CAL0128840">
        <property type="gene designation" value="CAGL0E06314g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06314g"/>
    <dbReference type="eggNOG" id="KOG2539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024759_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUY0"/>
    <dbReference type="OMA" id="HRKCPLQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180026">
        <property type="term" value="P:mitochondrial small ribosomal subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016522">
        <property type="entry name" value="RSM22_mit_bud"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007797">
        <property type="entry name" value="RSM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0128840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="73274" checksum="0B27D67591DABFC6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV21</accession>
    <name>Q6FV21_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="15">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="15">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">ALA1</name>
        <name evidence="17 18" type="ordered locus">CAGL0E05390g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 15">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="15"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445923.1">
        <property type="nucleotide sequence ID" value="XM_445923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV21"/>
    <dbReference type="FunCoup" id="Q6FV21">
        <property type="interactions" value="1054"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV21"/>
    <dbReference type="GeneID" id="2887324"/>
    <dbReference type="KEGG" id="cgr:2887324"/>
    <dbReference type="CGD" id="CAL0128942">
        <property type="gene designation" value="ALA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05390g"/>
    <dbReference type="eggNOG" id="KOG0188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FV21"/>
    <dbReference type="OMA" id="NKKDNFW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.40:FF:000003">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="16">
        <location>
            <begin position="9"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="600"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="719"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="723"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0128942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG58842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="956" mass="107028" checksum="322616C0C3573140" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV88</accession>
    <name>Q6FV88_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glycerol uptake/efflux facilitator protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FPS2</name>
        <name evidence="9 10" type="ordered locus">CAGL0E03894g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445856.1">
        <property type="nucleotide sequence ID" value="XM_445856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV88"/>
    <dbReference type="STRING" id="284593.Q6FV88"/>
    <dbReference type="GeneID" id="2887272"/>
    <dbReference type="KEGG" id="cgr:2887272"/>
    <dbReference type="CGD" id="CAL0128564">
        <property type="gene designation" value="FPS2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E03894g"/>
    <dbReference type="eggNOG" id="KOG0224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027014_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FV88"/>
    <dbReference type="OMA" id="CAINMAR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015793">
        <property type="term" value="P:glycerol transmembrane transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF9">
        <property type="entry name" value="AQUAPORIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="548"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0128564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="68102" checksum="7802FD5EEAC480E8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVB3</accession>
    <name>Q6FVB3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein phosphatase type 2A regulatory subunit RTS3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0E03267g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVB3"/>
    <dbReference type="STRING" id="284593.Q6FVB3"/>
    <dbReference type="KEGG" id="cgr:2887275"/>
    <dbReference type="CGD" id="CAL0128764">
        <property type="gene designation" value="CAGL0E03267g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E03267g"/>
    <dbReference type="eggNOG" id="ENOG502SBUT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1703982_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVB3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17646" checksum="2EED43B5CD5B92C3" modified="2004-07-19" version="1">MQDVPVKARRLSREQIINEMEKEQDAIVVKLLKEIETLKLENTRLRQRLAMFAEDAQNNNHSTQAARRRAGSVTSTTYSNSAILTDDEEDEDHNGHRRDSFLRVPVSPTHSRQASMSSSASSSSNRRPSLVVKEQRQLELLEFRKRNASLSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVC5</accession>
    <name>Q6FVC5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0E02981g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVC5"/>
    <dbReference type="FunCoup" id="Q6FVC5">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVC5"/>
    <dbReference type="KEGG" id="cgr:2887339"/>
    <dbReference type="CGD" id="CAL0128846">
        <property type="gene designation" value="CAGL0E02981g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02981g"/>
    <dbReference type="eggNOG" id="KOG2895">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018994_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FVC5"/>
    <dbReference type="OMA" id="YIDYYGK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106158">
        <property type="term" value="F:glycero-3-phosphocholine acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036151">
        <property type="term" value="P:phosphatidylcholine acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090640">
        <property type="term" value="P:phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0128846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG58738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="386" mass="45953" checksum="9AD7CA1DEB9EE9A6" modified="2004-07-19" version="1">MATEEKDELRSELSLGNLVELLDPIASKIHYTQFPTIQNYDYKKTWQRAKDKLNGDHKRLIKKHRERLVEQIKKWDGPLNRLFFHKTSTLEKLFYPFTLFNIFFIGFIMGRFPQYFHVYYTVLFCILIPIRFYTYYKTNNHYFLADLCYFVNILCLAYIWVFPRNQTLFLSCFALTFGSLSFAVITWRNSLVIHSIDKTTSCFIHIIPPCSIFVIYRAISPEYRAERFPGAVILDPRNSISLKTNIINTSLYYLIWQVLYHYFITLRKSSKIQAGQRETSFHYLTTHQYKDFWAVKLPTPWPIVIYTLSQYLYQLSTMLLCNIWIKYDEIWSQFFLLAIFLCAAHNGATYYIDYYGKSLENEVTKLKVEVEELQEELDMAQSGSDI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVD8</accession>
    <name>DNLI4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>DNA ligase 4</fullName>
            <ecNumber evidence="2">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>DNA ligase IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Polydeoxyribonucleotide synthase [ATP] 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">LIG4</name>
        <name type="ordered locus">CAGL0E02695g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVD8"/>
    <dbReference type="SMR" id="Q6FVD8"/>
    <dbReference type="FunCoup" id="Q6FVD8">
        <property type="interactions" value="613"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVD8"/>
    <dbReference type="EnsemblFungi" id="CAGL0E02695g-T">
        <property type="protein sequence ID" value="CAGL0E02695g-T-p1"/>
        <property type="gene ID" value="CAGL0E02695g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887446"/>
    <dbReference type="CGD" id="CAL0129066">
        <property type="gene designation" value="LIG4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_E02695g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02695g"/>
    <dbReference type="eggNOG" id="KOG0966">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004844_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FVD8"/>
    <dbReference type="OMA" id="EGIMIKH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097680">
        <property type="term" value="P:double-strand break repair via classical nonhomologous end joining"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07903">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07968">
        <property type="entry name" value="OBF_DNA_ligase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044125">
        <property type="entry name" value="Adenylation_DNA_ligase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF1">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000278378" description="DNA ligase 4">
        <location>
            <begin position="1"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT 1" evidence="4">
        <location>
            <begin position="688"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT 2" evidence="4">
        <location>
            <begin position="845"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="5">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P49917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q08387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="946" mass="109554" checksum="F6AC2CD321B55EEA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVK9</accession>
    <name>Q6FVK9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0E01089g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVK9"/>
    <dbReference type="FunCoup" id="Q6FVK9">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVK9"/>
    <dbReference type="KEGG" id="cgr:2887307"/>
    <dbReference type="CGD" id="CAL0129128">
        <property type="gene designation" value="CAGL0E01089g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01089g"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_8_6_1"/>
    <dbReference type="InParanoid" id="Q6FVK9"/>
    <dbReference type="OMA" id="FIRFYYG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF46">
        <property type="entry name" value="SPS-SENSOR COMPONENT SSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="622"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="755"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="283"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="853" mass="96590" checksum="4A5B7544F54ABA2A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVN1</accession>
    <name>Q6FVN1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TRX3</name>
        <name evidence="3 4" type="ordered locus">CAGL0E00583g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445713.1">
        <property type="nucleotide sequence ID" value="XM_445713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVN1"/>
    <dbReference type="FunCoup" id="Q6FVN1">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVN1"/>
    <dbReference type="GeneID" id="2887475"/>
    <dbReference type="KEGG" id="cgr:2887475"/>
    <dbReference type="CGD" id="CAL0128878">
        <property type="gene designation" value="TRX3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00583g"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_5_1"/>
    <dbReference type="InParanoid" id="Q6FVN1"/>
    <dbReference type="OMA" id="WCIPSVF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="18"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="141" mass="15942" checksum="E49AB46B4BD6481A" modified="2004-07-19" version="1">MLLFRTARCQVPTLGRFATHPRIAPSIAMRFQSSGGYASIKQVKTLEEVQKLMKDSNLSVIDFYATWCGPCKAMVPFLSKFVDQYKDVKFYKVDVDESPDVAEYYGVSAMPTFVFTKDDDILHKIRGANPKGLAKAIEEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVN7</accession>
    <name>Q6FVN7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">General negative regulator of transcription subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0E00451g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="1319"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVN7"/>
    <dbReference type="KEGG" id="cgr:2887526"/>
    <dbReference type="CGD" id="CAL0128634">
        <property type="gene designation" value="CAGL0E00451g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00451g"/>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000286_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FVN7"/>
    <dbReference type="OMA" id="VECHYQL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010607">
        <property type="term" value="P:negative regulation of cytoplasmic mRNA processing body assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:regulation of cell cycle"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000749">
        <property type="term" value="P:response to pheromone triggering conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032195">
        <property type="entry name" value="CNOT1_HEAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16419">
        <property type="entry name" value="CNOT1_HEAT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat 1" evidence="12">
        <location>
            <begin position="170"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="11">
        <location>
            <begin position="417"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="10">
        <location>
            <begin position="598"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="9">
        <location>
            <begin position="793"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="8">
        <location>
            <begin position="1091"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="13">
        <location>
            <begin position="1375"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="7">
        <location>
            <begin position="1695"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0128634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2090" mass="239098" checksum="0B8ADA0BCD306C43" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVR0</accession>
    <name>Q6FVR0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Aconitate hydratase, mitochondrial</fullName>
            <shortName evidence="14">Aconitase</shortName>
            <ecNumber evidence="14">4.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ACO1</name>
        <name evidence="17 18" type="ordered locus">CAGL0D06424g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.-" evidence="14"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445684.1">
        <property type="nucleotide sequence ID" value="XM_445684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVR0"/>
    <dbReference type="FunCoup" id="Q6FVR0">
        <property type="interactions" value="1003"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVR0"/>
    <dbReference type="GeneID" id="2887143"/>
    <dbReference type="KEGG" id="cgr:2887143"/>
    <dbReference type="CGD" id="CAL0127945">
        <property type="gene designation" value="ACO1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D06424g"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FVR0"/>
    <dbReference type="OMA" id="KKQGMLG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01578">
        <property type="entry name" value="AcnA_Mitochon_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01584">
        <property type="entry name" value="AcnA_Mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000004">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF3">
        <property type="entry name" value="ACONITATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="15">
        <location>
            <begin position="63"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="16">
        <location>
            <begin position="579"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0127945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG58595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="777" mass="85482" checksum="73CB6363F44F1C61" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVT5</accession>
    <name>Q6FVT5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0D05742g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVT5"/>
    <dbReference type="FunCoup" id="Q6FVT5">
        <property type="interactions" value="1175"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVT5"/>
    <dbReference type="KEGG" id="cgr:2887013"/>
    <dbReference type="CGD" id="CAL0128141">
        <property type="gene designation" value="CAGL0D05742g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05742g"/>
    <dbReference type="eggNOG" id="KOG2291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031381_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FVT5"/>
    <dbReference type="OMA" id="RYEYARE"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005143976" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="21"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0128141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="484" mass="54874" checksum="DED04F43BE988D02" modified="2004-07-19" version="1">MKAFAINWAFLFLFLGQVFGQAQEQKPYSGEASEKLAQEKPEWENLEYQRYLDLSGTGLAEEIRIVAKNVGDKPATDYHMLLPRNVIDNLSVFTATADNSSFVSFRALSATLKQLNNTAIGYGFLGLPRSVEPGETINLRLIYKFNDCGTPKPKKIGLGEDQFLVYETDRLPLSQYPTKMSILKITGSTDMSELDIGSVPEEYQGTFDDNVMTFGPFEDINALNVENKIKLRYLHNLALNEVIYLKRDIWVSHWASTIQFVEYNEYHNKGAELKNGFSRLEVMKNVQAANSPTVRGIIENHLPEQATEHYFVDKVGQVSTSQVLNNLFYLKPRFPIFGGWFYNYTIGWTNELSDFLRVSDMDSEEFILAVPLLNGPKDTAYDEVEYSVYLPEGATVIDTKSPLPVVQTTTSFESSYFDLKNGHTKVTLKFRNLVSELADGKILITYKLTNANFYGKFLNISLYGFIALMAIFLLNSINLRVSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVV2</accession>
    <name>Q6FVV2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0D05346g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVV2"/>
    <dbReference type="FunCoup" id="Q6FVV2">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVV2"/>
    <dbReference type="KEGG" id="cgr:2887145"/>
    <dbReference type="CGD" id="CAL0128167">
        <property type="gene designation" value="CAGL0D05346g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05346g"/>
    <dbReference type="eggNOG" id="KOG3487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085828_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVV2"/>
    <dbReference type="OMA" id="RYMNQFI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19297" checksum="C8E7058372289A52" modified="2004-07-19" version="1">MPQYFAIIGDHDRPLYEAEFTQGPQGFVQEIKELNPFILHASLDIVEDLQWQQNAGTGVAGGAGNSFLRSRNNANTDNCYLGKVDHFYGLVVTAYLTYGGKKFVMLHGSSVPGGNKTTTTTIDDSMVRSFYQEVHELYIKTIMNPFYQEGDELRSPLFDTRVKALAKKYLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVZ9</accession>
    <name>Q6FVZ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 24" type="primary">NCP1</name>
        <name evidence="24 25" type="ordered locus">CAGL0D04114g</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445595.1">
        <property type="nucleotide sequence ID" value="XM_445595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVZ9"/>
    <dbReference type="SMR" id="Q6FVZ9"/>
    <dbReference type="FunCoup" id="Q6FVZ9">
        <property type="interactions" value="886"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVZ9"/>
    <dbReference type="GeneID" id="2887077"/>
    <dbReference type="KEGG" id="cgr:2887077"/>
    <dbReference type="CGD" id="CAL0128329">
        <property type="gene designation" value="NCP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D04114g"/>
    <dbReference type="eggNOG" id="KOG1158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_3_1"/>
    <dbReference type="InParanoid" id="Q6FVZ9"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000036">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
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    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
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    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
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    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
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    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="61"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="268"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="67"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="441"/>
            <end position="444"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="459"/>
            <end position="461"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="478"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
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        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="606"/>
            <end position="607"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="613"/>
            <end position="617"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="687"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="CGD" id="CAL0128329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="CAG58506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="687" mass="76731" checksum="F3E4229B44424802" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW15</accession>
    <name>Q6FW15_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0D03762g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW15"/>
    <dbReference type="FunCoup" id="Q6FW15">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW15"/>
    <dbReference type="KEGG" id="cgr:2887076"/>
    <dbReference type="CGD" id="CAL0128509">
        <property type="gene designation" value="CAGL0D03762g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03762g"/>
    <dbReference type="eggNOG" id="ENOG502SSPG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045871_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW15"/>
    <dbReference type="OMA" id="HHISHAN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0128509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="312" mass="34618" checksum="3644E0BF46E3A4B6" modified="2004-07-19" version="1">MDNTKPATGRKSLPKMNSIWIDEDQEEKLYNIQAQVMLNDDNSNDDLQNIMFLNSKTPLLNNKKNIELPPLDENQGKTGKTPKNAKVNQKTKGNSQEARISTMKLLKLFGSRKETKPLTISTPFDFQHISHANGFSSAAEAREVERHELKRETLQTPRASIDLTQVALQSPVRLSTKPNYHHSSSSRSSSKFSESPSGSSGIMSNFTVDTSVDEVSVELLTTENKDDDSVYLNDLKNYNFPSIISQSLDNMQSNSSKENSTSKLTSEDPSPTDIAPSIGKKQRISVDDILRFYSGNSNSRSSTQASIPIKGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-23" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW61</accession>
    <name>RIX1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RIX1</name>
        <name type="ordered locus">CAGL0D02706g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445533.1">
        <property type="nucleotide sequence ID" value="XM_445533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW61"/>
    <dbReference type="SMR" id="Q6FW61"/>
    <dbReference type="FunCoup" id="Q6FW61">
        <property type="interactions" value="352"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW61"/>
    <dbReference type="EnsemblFungi" id="CAGL0D02706g-T">
        <property type="protein sequence ID" value="CAGL0D02706g-T-p1"/>
        <property type="gene ID" value="CAGL0D02706g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887183"/>
    <dbReference type="KEGG" id="cgr:2887183"/>
    <dbReference type="CGD" id="CAL0128053">
        <property type="gene designation" value="RIX1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02706g"/>
    <dbReference type="eggNOG" id="ENOG502R65X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020084_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW61"/>
    <dbReference type="OMA" id="WCGINLI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000308916" description="Pre-rRNA-processing protein RIX1">
        <location>
            <begin position="1"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="767" mass="87354" checksum="93062B59B8B3C9E5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWB4</accession>
    <name>Q6FWB4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0D01496g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWB4"/>
    <dbReference type="FunCoup" id="Q6FWB4">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWB4"/>
    <dbReference type="KEGG" id="cgr:2887116"/>
    <dbReference type="CGD" id="CAL0128131">
        <property type="gene designation" value="CAGL0D01496g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01496g"/>
    <dbReference type="eggNOG" id="KOG1119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069054_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FWB4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43011:SF1">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="2">
        <location>
            <begin position="92"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="226" mass="24819" checksum="245862CF3B8463EA" modified="2004-07-19" version="1">MRDSVTLDKTAVKMIGIRSVTVSRISVRGYARVVSMPKVIPMAKAMAKPMAKPMMNTMQNTRWYGIKVEASEGEVPLVEPYKVLNKQEDKGLKIAERAAKRLNEIYKESQEVLRVLVESGGCHGFQYNMKLVPESTLSLEETGNSESKTQEEVVDEFAEGADSSSKDVIYIVSEEGGKVAIDETSLGILNNTTLNYTTELIGSTFKITDGNLKSSCGCGSSFDIEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWD3</accession>
    <name>SC242_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein transport protein SEC24-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SEC242</name>
        <name type="ordered locus">CAGL0D01078g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445461.1">
        <property type="nucleotide sequence ID" value="XM_445461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWD3"/>
    <dbReference type="SMR" id="Q6FWD3"/>
    <dbReference type="FunCoup" id="Q6FWD3">
        <property type="interactions" value="875"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWD3"/>
    <dbReference type="EnsemblFungi" id="CAGL0D01078g-T">
        <property type="protein sequence ID" value="CAGL0D01078g-T-p1"/>
        <property type="gene ID" value="CAGL0D01078g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886987"/>
    <dbReference type="CGD" id="CAL0128245">
        <property type="gene designation" value="CAGL0D01078g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_D01078g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01078g"/>
    <dbReference type="eggNOG" id="KOG1985">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FWD3"/>
    <dbReference type="OMA" id="AVECSKQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000049">
        <property type="entry name" value="Vesicle coat component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000081">
        <property type="entry name" value="Vesicle coat component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000295483" description="Protein transport protein SEC24-2">
        <location>
            <begin position="1"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Zinc finger-like">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="906" mass="101317" checksum="9F7F30DAD60C1909" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWH0</accession>
    <name>Q6FWH0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Calnexin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0D00242g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWH0"/>
    <dbReference type="FunCoup" id="Q6FWH0">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWH0"/>
    <dbReference type="KEGG" id="cgr:2887148"/>
    <dbReference type="CGD" id="CAL0128113">
        <property type="gene designation" value="CAGL0D00242g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00242g"/>
    <dbReference type="eggNOG" id="KOG0675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_723599_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWH0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005144036" description="Calnexin-like protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0128113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="44078" checksum="AB257D14E80E93D0" modified="2004-07-19" version="1">MKSIGLLGLFFTAAHVHGRHLPINSTNISGFWEDFETYKTNEDLKEVWHSSEAVDEHGRKLFPASWKLFHNPDYVESNRKGLLVKSPGKYAMIGRNIEKPVNLSDSELLVIQYEVKSTKDPHCEGAFIKLFHNMYLESLTNYDRKAGVKYDLLFGPDFCLPDTNMVRFEWRNRKDKEEKKLIFSPKSKLNDGQHKNHLYTMILDLGNKILEIRIDGKVVLATSLNDSQHFKDTKYMSTTDTHEDSSEFNFSIDGLTFDIWGTLSGIVFKNVYIGNSIEEAEIIGNNTYLPNALKENDLILKKLKVKNDGKVPNAKSPYDDNIYSQNLFDILFDKLVGLLEGLSIKHMITVLLVLIPYMLYYLARNHEMKKRIRTEDIVEINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWU1</accession>
    <name>Q6FWU1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0C02893g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWU1"/>
    <dbReference type="FunCoup" id="Q6FWU1">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWU1"/>
    <dbReference type="KEGG" id="cgr:2886891"/>
    <dbReference type="CGD" id="CAL0127458">
        <property type="gene designation" value="CAGL0C02893g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02893g"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_82_2_1"/>
    <dbReference type="InParanoid" id="Q6FWU1"/>
    <dbReference type="OMA" id="EYAKKCT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF137">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="215"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="495"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="499"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0127458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="649" mass="73097" checksum="76AB1FE1E7B28C2F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWX3</accession>
    <name>Q6FWX3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SAH1</name>
        <name evidence="14 15" type="ordered locus">CAGL0C02189g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445271.1">
        <property type="nucleotide sequence ID" value="XM_445271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWX3"/>
    <dbReference type="FunCoup" id="Q6FWX3">
        <property type="interactions" value="1066"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWX3"/>
    <dbReference type="GeneID" id="2886930"/>
    <dbReference type="KEGG" id="cgr:2886930"/>
    <dbReference type="CGD" id="CAL0127182">
        <property type="gene designation" value="SAH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02189g"/>
    <dbReference type="eggNOG" id="KOG1370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FWX3"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0127182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="449" mass="49192" checksum="8C93D8B0B0888E26" modified="2004-07-19" version="1">MSAPAQNYKIADISLAAFGRKEIELAENEMPGLMAIRKAYAEAQPLKGARIAGCLHMTIQTAVLIETLVALGAEVTWTSCNIYSTQDHAAAAIAASGVPVFAWKGETEEEYMWCIEQQLFAFKDNKKLNLILDDGGDLTSFVHEKYPEMLTDCFGLSEETTTGVHHLYRMMREGKLKVPAINVNDAVTKSKFDNLYGCRESLVDGIKRATDVMLAGKVAVVAGFGDVGKGCAASLRGMGARVLVTEIDPINALQAAMEGYEVTTMEDAASVGQVFVTTTGCRDIIKGEHFEKMPEDAIVCNIGHFDIEIDVAWLKENAKECINIKPQVDRYLLSSGRHVILLANGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKSDDKAFRTKFVEFEKTGPFEVGVHVLPKILDEAVAKFHLEKLGVKLTTLSDVQSEYLGIPQQGPFKADHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWX6</accession>
    <name>Q6FWX6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0C02123g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWX6"/>
    <dbReference type="FunCoup" id="Q6FWX6">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWX6"/>
    <dbReference type="KEGG" id="cgr:2886889"/>
    <dbReference type="CGD" id="CAL0127216">
        <property type="gene designation" value="CAGL0C02123g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02123g"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037236_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FWX6"/>
    <dbReference type="OMA" id="AAYWERK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000116">
        <property type="entry name" value="Erj5p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273667" description="J domain-containing protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="12">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0127216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG58174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="297" mass="34389" checksum="631E8C958AA2F9C0" modified="2004-07-19" version="1">MVGISRQLVVLVCLLAVAYCFTAEEVEIFQLQKEIAKKYGDFYKFLKLPNGKSSTEKQINKNLRKLARKYHPDKNPKHKKLYARLNLATKILTNHSSRKTYDYYLKNGFPDYDFSKGGFFFQRAQPKTWFIIGFVLLVATAFHYIILKLQYNSNRRRIARFIQSCKEQDTTDGLGEKSLFFKQHEDDPGKELVLRFGDVFVIEEDGSESLISEDTIEEPKLTDALLFKFLNAVKNRTVGKLFKSTTKKLHEETTEKIDVAEDNSNDDKKPKAEMKIKPGQKKMTLPNGKVIYSRKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX30</accession>
    <name>Q6FX30_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0C00737g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX30"/>
    <dbReference type="FunCoup" id="Q6FX30">
        <property type="interactions" value="1163"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX30"/>
    <dbReference type="KEGG" id="cgr:2886797"/>
    <dbReference type="CGD" id="CAL0127366">
        <property type="gene designation" value="CAGL0C00737g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00737g"/>
    <dbReference type="eggNOG" id="KOG0319">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009276_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX30"/>
    <dbReference type="OMA" id="PYVQRHF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="386"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="491"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="533"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="575"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="617"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="6">
        <location>
            <begin position="670"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0127366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="816" mass="90582" checksum="17EAD709F1188A01" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX43</accession>
    <name>Q6FX43_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0C00451g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445201.1">
        <property type="nucleotide sequence ID" value="XM_445201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX43"/>
    <dbReference type="FunCoup" id="Q6FX43">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX43"/>
    <dbReference type="KEGG" id="cgr:2886725"/>
    <dbReference type="CGD" id="CAL0127576">
        <property type="gene designation" value="CAGL0C00451g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00451g"/>
    <dbReference type="eggNOG" id="ENOG502S03S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101036_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FX43"/>
    <dbReference type="OMA" id="TMQEDHE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008757">
        <property type="entry name" value="UCP008757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0127576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="177" mass="20122" checksum="75677D20B4C46ED5" modified="2004-07-19" version="1">MKLDGTLLTKLEKGKLSLEEIDKLEKKCFLSKFDSEDAYELGQFVRREVAETFPNKAVAINISLVNDHVLYHTVVGVASNDNDYWISRKKKTALRFGHSSYYMRIAKGDKTPQEKFFVDPKDYAFHGGAVPIFLENSDYPIAILTVSGLKQHEDHLFAVTSIIEYANKSREATLNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX69</accession>
    <name>Q6FX69_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0B00352g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX69"/>
    <dbReference type="FunCoup" id="Q6FX69">
        <property type="interactions" value="1221"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX69"/>
    <dbReference type="KEGG" id="cgr:2886586"/>
    <dbReference type="CGD" id="CAL0127796">
        <property type="gene designation" value="CAGL0B00352g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B00352g"/>
    <dbReference type="eggNOG" id="KOG2874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040185_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FX69"/>
    <dbReference type="OMA" id="TPDIDKW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="122"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="280"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="280"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0127796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG57885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="337" mass="39421" checksum="2DF026FE51AA76B8" modified="2004-07-19" version="1">MVSTYNKDKPWDTEDIDKWKIEEFKPEDNKSGQPFAEESSFMTLFPKYREAYLKSIWNDVTRALDKHHIGCTLDLVEGSMTVKTTRKTFDPAIILKARDLIKLLARSVPFPQAVKILQDDIACDVIKIGNTVANKDRFVKRRQRLVGPNGNTLKALELLTKCYILVQGNTVSAMGPYKGLKEIRRVVLDCMKNVHPIYHIKELMIKRELAKRPELANEDWSRFLPMFKKRNVARKKPSKVKAEKKVYTPFPPAQLPRKVDLQIESGEYFLSKKEKEIKKLHEQREKQAEKQILKDEERRKDYIAPKEDEYKSSHKSTKKRTSNEDKGDKDSKKRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXD1</accession>
    <name>Q6FXD1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 9">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0B01881g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 9"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXD1"/>
    <dbReference type="FunCoup" id="Q6FXD1">
        <property type="interactions" value="1288"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXD1"/>
    <dbReference type="KEGG" id="cgr:2886536"/>
    <dbReference type="CGD" id="CAL0127664">
        <property type="gene designation" value="CAGL0B01881g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01881g"/>
    <dbReference type="eggNOG" id="KOG1253">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FXD1"/>
    <dbReference type="OMA" id="MKCCHEM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140691">
        <property type="term" value="F:RNA folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160103">
        <property type="term" value="F:tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0127664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG57951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="553" mass="62476" checksum="374E13F79CF9BC36" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXW5</accession>
    <name>Q6FXW5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0A01067g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXW5"/>
    <dbReference type="FunCoup" id="Q6FXW5">
        <property type="interactions" value="679"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXW5"/>
    <dbReference type="KEGG" id="cgr:2886416"/>
    <dbReference type="CGD" id="CAL0126831">
        <property type="gene designation" value="CAGL0A01067g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01067g"/>
    <dbReference type="eggNOG" id="KOG1230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008722_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXW5"/>
    <dbReference type="OMA" id="PSPRVGC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="553"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0126831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG57708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="641" mass="74046" checksum="A0D33F33CC3CBA70" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY35</accession>
    <name>SVF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ceramide-binding protein SVF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Survival factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SVF1</name>
        <name type="ordered locus">CAGL0A02365g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ceramide-binding protein that may transfer ceramides from the endoplasmic reticulum membrane to the cis-Golgi network membrane, and is thereby required for the biosynthesis of complex sphingolipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Localizes to the interface between the cis-Golgi network and endoplasmic reticulum exit sites.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SVF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444867.1">
        <property type="nucleotide sequence ID" value="XM_444867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY35"/>
    <dbReference type="FunCoup" id="Q6FY35">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY35"/>
    <dbReference type="EnsemblFungi" id="CAGL0A02365g-T">
        <property type="protein sequence ID" value="CAGL0A02365g-T-p1"/>
        <property type="gene ID" value="CAGL0A02365g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886358"/>
    <dbReference type="KEGG" id="cgr:2886358"/>
    <dbReference type="CGD" id="CAL0126699">
        <property type="gene designation" value="CAGL0A02365g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02365g"/>
    <dbReference type="eggNOG" id="ENOG502QQY3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030205_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FY35"/>
    <dbReference type="OMA" id="AFWPRCV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033106">
        <property type="term" value="C:cis-Golgi network membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097001">
        <property type="term" value="F:ceramide binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051385">
        <property type="entry name" value="Ceramide-binding_SVF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033394">
        <property type="entry name" value="Svf1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013931">
        <property type="entry name" value="Svf1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107:SF1">
        <property type="entry name" value="CERAMIDE-BINDING PROTEIN SVF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47107">
        <property type="entry name" value="SVF1-LIKE PROTEIN YDR222W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08622">
        <property type="entry name" value="Svf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17187">
        <property type="entry name" value="Svf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000072328" description="Ceramide-binding protein SVF1">
        <location>
            <begin position="1"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Peripherally associates with membranes" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="203"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q05515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="443" mass="50546" checksum="E9B19264251732A1" modified="2004-07-19" version="1">MLKWIQGGLSAVTGIAEPEYGKEYIHTVTERVEGKQPYRETTREDFFWKSPDHTNVETVTFYFSNLATGVVGFAQIIHSNIIGLHTAAQFTFRIFDSKNPEKLNLWTSTKLENFRIEDANFYADDLSVELNADNTQYRLISKVNEQSIVDLTVTRLTPGAKLGDDPSTYYGDNVEQPWGSMRHVFWPRNTCVGEIKVKIPKETAEKTAEEQAQEKEQQEEQEQEGEDEAVEETIEYEERTLKFGEDDPSYCMFVMAFQGMKPHHAAKAWNFMFFHSKENTMVLMEFTTPKSYSNTKVSIGIITNDKEILAVTHDNSALHLNQEIDSVGWNVPKQIRVELKGHKSSAKDEDVEADNDEHKIKAVVEGPLENMVERIDVMGEVPNFVKNIVSGVAGTKPYIYQFGDAENFHFQLDDGEKKNGLAWVEVTFISESEVVTEESYNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY47</accession>
    <name>Q6FY47_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0A02970g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY47"/>
    <dbReference type="SMR" id="Q6FY47"/>
    <dbReference type="FunCoup" id="Q6FY47">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY47"/>
    <dbReference type="KEGG" id="cgr:2886417"/>
    <dbReference type="CGD" id="CAL0126965">
        <property type="gene designation" value="CAGL0A02970g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02970g"/>
    <dbReference type="eggNOG" id="KOG1901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064798_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FY47"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019220">
        <property type="term" value="P:regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="1">
        <location>
            <begin position="158"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0126965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG57788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="309" mass="35547" checksum="CA202FDFD20D177F" modified="2004-07-19" version="1">MKLIAAETPQKKFAMRTIEDSLKELEGLLHGGRVLRLPDLDHRYTIMSYENYEQRSADVPRQQICDTSRQRDNAYKVVPVTHTTHSADINSDFITNYKLSTPTQGLTTNVRTNPTVDVLTESKPNYQYYNKPTKLKASVKRKKSLAIVPAWVNVPEFSRFFVIKSISLDHIKKSFYNSIWSSTHFGNRKLSQAYKELKAGAKIFLFFSVNASGRFCGVAEMSSDLQDCLDTSLWDDSSKYGAAFRVRWVLVKDLKNAHLKRFLIPENEMKPITKSRDTQEIPFYIGQAVLQLFKSDNTNIKCFLDQDYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY50</accession>
    <name>Q6FY50_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0A02904g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY50"/>
    <dbReference type="SMR" id="Q6FY50"/>
    <dbReference type="FunCoup" id="Q6FY50">
        <property type="interactions" value="633"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY50"/>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886418"/>
    <dbReference type="CGD" id="CAL0126909">
        <property type="gene designation" value="CAGL0A02904g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02904g"/>
    <dbReference type="eggNOG" id="KOG2806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FY50"/>
    <dbReference type="OMA" id="FYYCSGG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035885">
        <property type="term" value="F:exochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="56"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0126909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG57785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="501" mass="58204" checksum="9C2E833A9B8F8631" modified="2004-07-19" version="1">MHIGHRKRLGTFIVILITSLILQMSLHYKIFQKLKRRSQSDDYRMPESDVLSNTSYIAGLYYSNWSPYEPRLHFPHDIDFEKVSHIYYAFLLIDPETGNLTSSDEWSDTQLNLAKQCREYMFKRFTGDELKAVTNIRAPPGCIGELNYLRYIYSKIKKRNVKLIMSVGGWSNRESFPIMVRDELKFKNFINSCIETMVYYGFDGIDLDWEFPEDDSYEPDAYLRMARELKLQLQKLEANILGDHSNKTFQLSMATPAFKDKLSILPIHKLDKYIDLWNLMTYDYYGEWSERTGLHANLYNEKGKLLHLHRHDEDAGLSGDAAINYMVNRCKIDPRKVILGMAAYGRGFTNVDMKSTNPHNPYGLKFSGVGGASEGEPGMWLYNQLPIPGSNEKYDYRHVGAYCYDDRTHTLVGYDNPTSVIEKANYIMSNSLGGAFWWESCGDTHKNPKRSLLNTYIRVIRNVKNNKETIYSTTKLHDYYLENYDTNGFLTGFIKDIIQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FYA9</accession>
    <name>Q6FYA9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0A03190g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FYA9"/>
    <dbReference type="FunCoup" id="Q6FYA9">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FYA9"/>
    <dbReference type="KEGG" id="cgr:2886350"/>
    <dbReference type="CGD" id="CAL0126829">
        <property type="gene designation" value="CAGL0A03190g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A03190g"/>
    <dbReference type="eggNOG" id="ENOG502S64F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101503_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FYA9"/>
    <dbReference type="OMA" id="YELENEW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0126829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG57799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="241" mass="27657" checksum="DD06B13B863EC33E" modified="2004-07-19" version="1">MDISVPESQVYADITGFIEQQQRELTNINEYLDDSDAVPVEVQELVELGYRNKLRSKTRTTSTDLLVKNVYELENEWKLRTMTEMMDIIGDIPKHSIGSELRESIEDPAGHSHNAAIDDLIEDILKLPQLQLADTAHEDDDNAQLLREYRNLKNDVIDKCNEIVASRQELRDMDINLEPVRSLLKAIPHSSEGDIRQYFIDYQGQLESVVKELSLVVEEAYKQSENDPIMRGKLADIINNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B4UMX1</accession>
    <name>B4UMX1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mediator of RNA polymerase II transcription subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PGD1</name>
        <name evidence="2 3" type="ordered locus">CAGL0A01325g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAR57995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002999511.1">
        <property type="nucleotide sequence ID" value="XM_002999465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UMX1"/>
    <dbReference type="STRING" id="284593.B4UMX1"/>
    <dbReference type="GeneID" id="9487959"/>
    <dbReference type="KEGG" id="cgr:9487959"/>
    <dbReference type="CGD" id="CAL0126649">
        <property type="gene designation" value="PGD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01325g"/>
    <dbReference type="eggNOG" id="ENOG502S3GT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049224_0_0_1"/>
    <dbReference type="InParanoid" id="B4UMX1"/>
    <dbReference type="OMA" id="ENEMSMN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020998">
        <property type="entry name" value="Med3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11593">
        <property type="entry name" value="Med3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0126649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAR57995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="51681" checksum="0CF8AF5968C49595" modified="2008-09-23" version="1">MATKQEEQANLSDVLTPSMSLTELEMKFADETDGKAKDVVQARIKKAEDGILPLRLQFNDFTQIMSSLDEERYANVSKQEKFQMIRSKVLGLTERLQELSNDFEELQPLFATVGEYSKTYKNKNFQVLENLASYNHRGKAGASISNSTPTPAAATPTTAPTPGAGTKKAAKTAPTPTATATIGTPSNNAPTPATTATTPGTQAKKPRKPRQTKKQQQAAAAAAAVAQAQAQAQAQAQNQNQNNMQNKNISNPGMNSNMGTPVMGNPNMKQMQSPIPANAMNNMNVPHNGAMRPSVPNGNMGNPSMGNLNMNAPNMGNPNMNNPNMNNPNAMMSPMAGQGQLNQMFPMQNHNQNGHFMGQQSPGPNIGQMQFPPNNGNMNGMPGTSDMNLGMNPSMNMNMGMNMNQITPANILSMNTKGKDDQMQNIGMDQNQNQNQNQNQNQSMNMNMNNDSNNPKSAYDLVDFNSLDLSSLNMDFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-06-07" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>P61833</accession>
    <accession>Q8NJS5</accession>
    <name>H3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HHT1</name>
        <name type="ordered locus">CAGL0C04114g</name>
    </gene>
    <gene>
        <name type="primary">HHT2</name>
        <name type="ordered locus">CAGL0H09856g</name>
    </gene>
    <gene>
        <name type="primary">HHT3</name>
        <name type="ordered locus">CAGL0M06655g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Proc. Natl. Acad. Sci. U.S.A." volume="99" first="9272" last="9277">
            <title>Gene order evolution and paleopolyploidy in hemiascomycete yeasts.</title>
            <authorList>
                <person name="Wong S."/>
                <person name="Butler G."/>
                <person name="Wolfe K.H."/>
            </authorList>
            <dbReference type="PubMed" id="12093907"/>
            <dbReference type="DOI" id="10.1073/pnas.142101099"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text>The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by IPL1 to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation by GCN5 and is required for transcriptional activation through TBP recruitment to the promoters.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Mono-, di- and trimethylated by the COMPASS complex to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. Methylated by SET2 to form H3K36me. H3K36me represses gene expression. Methylated by DOT1 to form H3K79me. H3K79me is required for association of SIR proteins with telomeric regions and for telomeric silencing. The COMPASS-mediated formation of H3K4me2/3 and the DOT1-mediated formation of H3K79me require H2BK123ub1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5 is promoted by H3S10ph. H3K14ac can also be formed by ESA1. H3K56ac formation occurs predominantly in newly synthesized H3 molecules during G1, S and G2/M of the cell cycle and may be involved in DNA repair.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3S10ph = phosphorylated Ser-11; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-37; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37; H3K56ac = acetylated Lys-57; H3K64ac = acetylated Lys-65; H3K79me1/2/3 = mono-, di- and trimethylated Lys-80.</text>
    </comment>
    <dbReference type="EMBL" id="AF520060">
        <property type="protein sequence ID" value="AAM74211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF520061">
        <property type="protein sequence ID" value="AAM74217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445354.1">
        <property type="nucleotide sequence ID" value="XM_445354.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447226.1">
        <property type="nucleotide sequence ID" value="XM_447226.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449637.1">
        <property type="nucleotide sequence ID" value="XM_449637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P61833"/>
    <dbReference type="SMR" id="P61833"/>
    <dbReference type="FunCoup" id="P61833">
        <property type="interactions" value="1074"/>
    </dbReference>
    <dbReference type="STRING" id="284593.P61833"/>
    <dbReference type="EnsemblFungi" id="CAGL0C04114g-T">
        <property type="protein sequence ID" value="CAGL0C04114g-T-p1"/>
        <property type="gene ID" value="CAGL0C04114g"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0H09856g-T">
        <property type="protein sequence ID" value="CAGL0H09856g-T-p1"/>
        <property type="gene ID" value="CAGL0H09856g"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0M06655g-T">
        <property type="protein sequence ID" value="CAGL0M06655g-T-p1"/>
        <property type="gene ID" value="CAGL0M06655g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886846"/>
    <dbReference type="GeneID" id="2891685"/>
    <dbReference type="KEGG" id="cgr:2886846"/>
    <dbReference type="KEGG" id="cgr:2888834"/>
    <dbReference type="KEGG" id="cgr:2891685"/>
    <dbReference type="CGD" id="CAL0127444">
        <property type="gene designation" value="HHT1"/>
    </dbReference>
    <dbReference type="CGD" id="CAL0136971">
        <property type="gene designation" value="HHT2"/>
    </dbReference>
    <dbReference type="CGD" id="CAL0130591">
        <property type="gene designation" value="HHT3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_C04114g"/>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H09856g"/>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M06655g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04114g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09856g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06655g"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078295_4_0_1"/>
    <dbReference type="InParanoid" id="P61833"/>
    <dbReference type="OMA" id="HIFAEMA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000010">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0544">Nucleosome core</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000221358" description="Histone H3">
        <location>
            <begin position="2"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6,N6-trimethyllysine; alternate" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6,N6-trimethyllysine; alternate" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6,N6-trimethyllysine; alternate" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6,N6-trimethyllysine; alternate" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6,N6-dimethyllysine; alternate" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-methyllysine; alternate" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAM74217." evidence="3" ref="1">
        <original>K</original>
        <variation>N</variation>
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="136" mass="15356" checksum="A6115FEB480AC67A" modified="2007-01-23" version="2">MARTKQTARKSTGGKAPRKQLASKAARKSAPSTGGVKKPHRYKPGTVALREIRRFQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAIGALQESVEAYLVSLFEDTNLAAIHAKRVTIQKKDIKLARRLRGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIL0</accession>
    <name>Q6FIL0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="5">Glu-AdT subunit A</shortName>
            <ecNumber evidence="5">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HER2</name>
        <name evidence="7 8" type="ordered locus">CAGL0M13585g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="5"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449934.1">
        <property type="nucleotide sequence ID" value="XM_449934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIL0"/>
    <dbReference type="FunCoup" id="Q6FIL0">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIL0"/>
    <dbReference type="GeneID" id="2891225"/>
    <dbReference type="KEGG" id="cgr:2891225"/>
    <dbReference type="CGD" id="CAL0136335">
        <property type="gene designation" value="CAGL0M13585g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13585g"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_7_6_1"/>
    <dbReference type="InParanoid" id="Q6FIL0"/>
    <dbReference type="OMA" id="QPASYCG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="467" mass="51862" checksum="26FDD2FB5E810696" modified="2004-07-19" version="1">MSISRLRALPELQKQYNIFTHIDVEGVKNSYKSLKDGILSGLLCGIKDNIVTKDMPTTCGSEILRGYQSPYDATVVKLLKQEGSIVLGKTNLDEFGMGSRGIHSCFGPTFNPLYPAADKVIMGGSSSGSAAAVVSEAVDFSLGTDTGGSVRLPATYGSIYGFKPSYGRISRYGVIAYAQSLDTVGILTKNISTLRKVYHVLDKYDDKDPTSLENSYRDQILGIHERNTIKERKKYRIGIAKEFSQDSIPETIMEALLAFVKKLLDLGHDVVPISIPSIKNALPIYYTLSPAEAVSNLSRFDGIRYGYRDQESDMSDNVMFAPTRKQFGREVKNRILLGNYNLCSESFKNNYIRAQKLRVQLIDEMDSVFRYPNVLLNNKETTKSETNVDFLISLTTPSLPKKLEDFSVSDLDTPTKEYINDVFTMPMSLAGLPTLSIPIIPGQPIGVQLVGQYGFDEMVLDFAEMIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIP6</accession>
    <name>Q6FIP6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M12771g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIP6"/>
    <dbReference type="FunCoup" id="Q6FIP6">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIP6"/>
    <dbReference type="KEGG" id="cgr:2891449"/>
    <dbReference type="CGD" id="CAL0136577">
        <property type="gene designation" value="CAGL0M12771g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M12771g"/>
    <dbReference type="eggNOG" id="KOG4652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033649_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIP6"/>
    <dbReference type="OMA" id="MRLMFNE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000800">
        <property type="term" value="C:lateral element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010846">
        <property type="term" value="P:activation of reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016573">
        <property type="entry name" value="Hop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010751">
        <property type="entry name" value="HOP1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="6">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="592" mass="68398" checksum="668CF16418138703" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIP9</accession>
    <name>Q6FIP9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PHM4</name>
        <name evidence="7 8" type="ordered locus">CAGL0M12705g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIP9"/>
    <dbReference type="FunCoup" id="Q6FIP9">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIP9"/>
    <dbReference type="KEGG" id="cgr:2891446"/>
    <dbReference type="CGD" id="CAL0137315">
        <property type="gene designation" value="PHM4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M12705g"/>
    <dbReference type="eggNOG" id="KOG4580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141247_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FIP9"/>
    <dbReference type="OMA" id="MAIMIYA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="6">
        <location>
            <begin position="24"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0137315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="127" mass="14077" checksum="39F303DC83E2741F" modified="2004-07-19" version="1">MSSAPLLQKTPGKKIALPTRVEPKVFFANERTFLSWLNFTVMLGGLGVGLLNFGDKVGKISAALFTLIAMGSMIYALVTYHWRAAAIRRRGSGPYDDRLGPTLLCFFLLFAVVTNFILRTKYENTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIW8</accession>
    <name>Q6FIW8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M11176g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIW8"/>
    <dbReference type="FunCoup" id="Q6FIW8">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="ESTHER" id="canga-q6fiw8">
        <property type="family name" value="FSH1"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891395"/>
    <dbReference type="CGD" id="CAL0136895">
        <property type="gene designation" value="CAGL0M11176g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11176g"/>
    <dbReference type="eggNOG" id="KOG2551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051938_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FIW8"/>
    <dbReference type="OMA" id="CYSGFIA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0136895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="219" mass="24517" checksum="C7A58CBE6A972EA2" modified="2004-07-19" version="1">MAKKVLMLHGLAQSGEYFASKTKGFAAELEKLDYELYYPTAPNSFPPADLPNGLLDEIDDKVSSQSGVIAWLQNKETGDGYYIPETTINYLHNYIIENGPFDGIVGFSQGAGLAGYLVTDFNGLLNLTEEEQPPLKFLMAFSGFRFRGEEHQKQYKNPISIKTLHVHGELDTVTEPEKVQALYDSCDSSSRTFLTHKGGHFIPNSRGFLKKVVEWLNEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ36</accession>
    <name>MED19_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ROX3</name>
        <name type="synonym">MED19</name>
        <name type="ordered locus">CAGL0M09515g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449758.1">
        <property type="nucleotide sequence ID" value="XM_449758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ36"/>
    <dbReference type="SMR" id="Q6FJ36"/>
    <dbReference type="FunCoup" id="Q6FJ36">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ36"/>
    <dbReference type="EnsemblFungi" id="CAGL0M09515g-T">
        <property type="protein sequence ID" value="CAGL0M09515g-T-p1"/>
        <property type="gene ID" value="CAGL0M09515g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891322"/>
    <dbReference type="KEGG" id="cgr:2891322"/>
    <dbReference type="CGD" id="CAL0136373">
        <property type="gene designation" value="CAGL0M09515g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M09515g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09515g"/>
    <dbReference type="eggNOG" id="ENOG502QXG3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117719_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ36"/>
    <dbReference type="OMA" id="SYPTEFQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001113">
        <property type="term" value="P:transcription open complex formation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28270:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000304776" description="Mediator of RNA polymerase II transcription subunit 19">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="201" mass="23358" checksum="55C70B7CD62EF5BC" modified="2004-07-19" version="1">MEMEEFAPSYYYYVEPEMGYQPQQPNPMEDLITVYHLDDISRQVARTNEDGTKAVKLRKSYKNQITDLSGKFSSIPNRENRKGGEIAHILFQNNPDMMNQVHRSPDMTDEQWREALMNVDASLFQAPNMDWEVCQSVLSQFDRSYPTEFQNDPNFHVDDLAFDLDGTGKSNAKKRKNRSNGSSMATPNSEMQDDVKRRRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ64</accession>
    <name>Q6FJ64_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal lysine N-methyltransferase 4</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0M08844g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ64"/>
    <dbReference type="FunCoup" id="Q6FJ64">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ64"/>
    <dbReference type="KEGG" id="cgr:2891291"/>
    <dbReference type="CGD" id="CAL0136607">
        <property type="gene designation" value="CAGL0M08844g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08844g"/>
    <dbReference type="eggNOG" id="KOG1338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017135_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ64"/>
    <dbReference type="OMA" id="RESAEDM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1410.10:FF:000007">
        <property type="entry name" value="Ribosomal lysine N-methyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0136607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="510" mass="58967" checksum="8A1A48896D625DC1" modified="2004-07-19" version="1">MADNYTETTTEYVSWLTNNGVKISPKLKVEDNRYKDEGRCVVTTTDIQKDELLFEIPRNVLLNCETSQLVKDIPAVLTELETFSGSEPLSWEPLILCLFYEMYILKDKSRWWPYFEVLPTLEDMNVLVLWSDEDLAALEPSYVLSCIGKEQVENMYQLLKRFIEASDHEQLKSNLNKFSWDSFIRIGSLIMSYSFDVGKEIHNEGKEGESMNENDNMTNGDEDEDEDEEDLEVEMIKSMVPLADTLNADTKKCNANLLHSKQTLRMIAIRDIPSGEQVYNTYGELSNSELLRRYGYVEWDGSYYDCGEISKSAIHKSLLQLFPTSTETLERLDAVIDENEKVLDLFDDDTIVEDTYIFESDGEIPFKFLFYIQLMALLLQNSRIEKMGPIALNKCMAPTIDKTSKILQEQKVTRKALDVLNDSLDTRMKQYEQKITDSGEDSLEPPSHEASTKEKRMRMVKMILLSEYKSLRKCSEVIREEFGPLSDSDVLSEIKQSKEEKRPKKRAKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ83</accession>
    <name>Q6FJ83_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">CAGL0M08404g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="2"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ83"/>
    <dbReference type="FunCoup" id="Q6FJ83">
        <property type="interactions" value="874"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ83"/>
    <dbReference type="KEGG" id="cgr:2891270"/>
    <dbReference type="eggNOG" id="KOG0616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="InParanoid" id="Q6FJ83"/>
    <dbReference type="OMA" id="KHTVVKL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010607">
        <property type="term" value="P:negative regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF73">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="152"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="407"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="15"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG62687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="462" mass="53754" checksum="A8FD95EE67D21653" modified="2004-07-19" version="1">MQILGENFKEVEIMDSEYDRRKLEEESAGPPGDEPMGQENHEQLENHIDKATESQMSKELVVEDDQYDQGSHNIDYEARNKEEHNNGTNRTDGGHTQGTEQSNEQQTESNHEQQQQQRLQQTEQHQQHQMETVKKPLIYGANTSGKYTLSDFQILRTLGTGSFGRVHLIRSNHNGRFYALKALKKHTVVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQHVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKEIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGILIYEMLAGYTPFYDANTMKTYEHILNSELKFPSFFHPDVQDLLSKLITRDLSKRLGNLQNGSEDVKNHPWFSEVVWEKLLARYIETPYEPPIQQGQGDTSQFDRYPEEEINYGVQGEDPYADLFREF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ85</accession>
    <name>KKQ8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Probable serine/threonine-protein kinase KKQ8</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">KKQ8</name>
        <name type="ordered locus">CAGL0M08360g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NPR/HAL subfamily. HAL5 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449709.1">
        <property type="nucleotide sequence ID" value="XM_449709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ85"/>
    <dbReference type="SMR" id="Q6FJ85"/>
    <dbReference type="FunCoup" id="Q6FJ85">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ85"/>
    <dbReference type="EnsemblFungi" id="CAGL0M08360g-T">
        <property type="protein sequence ID" value="CAGL0M08360g-T-p1"/>
        <property type="gene ID" value="CAGL0M08360g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891268"/>
    <dbReference type="KEGG" id="cgr:2891268"/>
    <dbReference type="CGD" id="CAL0136865">
        <property type="gene designation" value="CAGL0M08360g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08360g"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016904_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ85"/>
    <dbReference type="OMA" id="EFYVFEE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF43">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE HAL5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000333585" description="Probable serine/threonine-protein kinase KKQ8">
        <location>
            <begin position="1"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="449"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="419"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="455"/>
            <end position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="766" mass="85781" checksum="C7A827898C85833E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJA4</accession>
    <name>Q6FJA4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0M07898g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TOG/XMAP215 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJA4"/>
    <dbReference type="FunCoup" id="Q6FJA4">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJA4"/>
    <dbReference type="KEGG" id="cgr:2891741"/>
    <dbReference type="CGD" id="CAL0136751">
        <property type="gene designation" value="CAGL0M07898g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07898g"/>
    <dbReference type="eggNOG" id="KOG1820">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008401_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FJA4"/>
    <dbReference type="OMA" id="ACLNTIM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099606">
        <property type="term" value="P:microtubule plus-end directed mitotic chromosome migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140273">
        <property type="term" value="P:repair of mitotic kinetochore microtubule attachment defect"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048492">
        <property type="entry name" value="Stu2_CTS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21042">
        <property type="entry name" value="Stu2_CTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="304"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="492"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="667"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0136751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="825" mass="93193" checksum="AFEE1C2CB264A1A5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJI9</accession>
    <name>FMP46_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Putative redox protein FMP46, mitochondrial</fullName>
            <ecNumber>1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FMP46</name>
        <name type="ordered locus">CAGL0M05951g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449605.1">
        <property type="nucleotide sequence ID" value="XM_449605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJI9"/>
    <dbReference type="SMR" id="Q6FJI9"/>
    <dbReference type="FunCoup" id="Q6FJI9">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0M05951g-T">
        <property type="protein sequence ID" value="CAGL0M05951g-T-p1"/>
        <property type="gene ID" value="CAGL0M05951g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891653"/>
    <dbReference type="KEGG" id="cgr:2891653"/>
    <dbReference type="CGD" id="CAL0137471">
        <property type="gene designation" value="CAGL0M05951g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M05951g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05951g"/>
    <dbReference type="eggNOG" id="ENOG502S4SU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1939538_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJI9"/>
    <dbReference type="OMA" id="LWVDWEK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051051">
        <property type="term" value="P:negative regulation of transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000292447" description="Putative redox protein FMP46, mitochondrial">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="129" mass="15128" checksum="3C5428081C028B33" modified="2004-07-19" version="1" precursor="true">MSMFRTLQRQPRTISLFTHDLENSRPCLSILEYLKSHTTNRFDLELSTKFPTLDQVHYMNAINPMILRAQIPHLTKIMKLKSYDPLFGSQLSDCVTKGFWNKEAPLWVDWEKKALGTDLQSIKELLEKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJJ9</accession>
    <name>ALG2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="1">2.4.1.132</ecNumber>
            <ecNumber evidence="1">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Asparagine-linked glycosylation protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ALG2</name>
        <name type="ordered locus">CAGL0M05731g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="1"/>
    <dbReference type="EC" id="2.4.1.257" evidence="1"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449595.1">
        <property type="nucleotide sequence ID" value="XM_449595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJJ9"/>
    <dbReference type="FunCoup" id="Q6FJJ9">
        <property type="interactions" value="761"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJJ9"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q6FJJ9">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0M05731g-T">
        <property type="protein sequence ID" value="CAGL0M05731g-T-p1"/>
        <property type="gene ID" value="CAGL0M05731g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891643"/>
    <dbReference type="KEGG" id="cgr:2891643"/>
    <dbReference type="CGD" id="CAL0137195">
        <property type="gene designation" value="ALG2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05731g"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030619_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FJJ9"/>
    <dbReference type="OMA" id="AMYMKCP"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033164">
        <property type="term" value="F:initiation-specific glycolipid 1,6-alpha-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000080264" description="Alpha-1,3/1,6-mannosyltransferase ALG2">
        <location>
            <begin position="1"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P43636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="458" mass="52255" checksum="C6AC3B19E3ACDEC0" modified="2004-07-19" version="1">MVPAKKLKIAFVHPDLGIGGAERLVVDAALGLQEAGHEVIIYTSHCDKTHCFEEVKNGTLKVEVFGDFLPTDLGKRFFIVFANLRQLYLTAKVVLSGRSKDKDVFIIDQLSTCVPFFKLANNKVLFYCHFPDQLLAIRTNWIKSLYRIPFDLLEQFTMYCSDEVVVNSNFTKSMYKKTFKYLQKNPNVIYPCVDTDTETLINDRDMQIGNLLVGKCPNFYLSINRYERKKNIELAIQAFAKASVENTNLVVCGGYDPRIHENVQYLQELTCLCKELDLSYTVNHYSDFIEDSYSVNEIEKLFGAKVIFLTSISSSLKEFLIQNMQLLLYTPSYEHFGIVPLEAMKYGKPVLAVNNGGPVETVVSYQKEDNEKSTTGWLRSADADEWASALIESKEVLNQNPELFKNNGPKRVIELFSRKAMTQEFETNIKLALRHTSNISIIYVVSIIFAVLLKVFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJM2</accession>
    <name>Q6FJM2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M05203g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62548.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJM2"/>
    <dbReference type="FunCoup" id="Q6FJM2">
        <property type="interactions" value="696"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJM2"/>
    <dbReference type="KEGG" id="cgr:2891584"/>
    <dbReference type="CGD" id="CAL0137419">
        <property type="gene designation" value="CAGL0M05203g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05203g"/>
    <dbReference type="eggNOG" id="KOG2434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010579_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FJM2"/>
    <dbReference type="OMA" id="FKHFYAA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62548.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="70793" checksum="B6853487CABC7396" modified="2008-09-23" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJM7</accession>
    <name>Q6FJM7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 14">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0M05049g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for normal synthesis of the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 14"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJM7"/>
    <dbReference type="FunCoup" id="Q6FJM7">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJM7"/>
    <dbReference type="CAZy" id="GH76">
        <property type="family name" value="Glycoside Hydrolase Family 76"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891577"/>
    <dbReference type="CGD" id="CAL0136343">
        <property type="gene designation" value="CAGL0M05049g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05049g"/>
    <dbReference type="eggNOG" id="ENOG502QWHG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FJM7"/>
    <dbReference type="OMA" id="GMFQPPY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF21">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DFG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273423" description="Mannan endo-1,6-alpha-mannosidase" evidence="16">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0136343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG62543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="453" mass="49457" checksum="68F7332FB8BED65B" modified="2004-07-19" version="1">MKLLFSLQLWVLIGTLFPDAGAINLQDNKDSICAATALIQGGMLDYYEGTRYGGTVGMFQPPYYWWQAGVAFGGMLENWFLCQNDTYKDLLMNALVAQTGPNYDYIPANQTTVEGNDDQGVWGLTILDAVERNFSAPIDGKPGWLAMSQGIFNTMYARWDMQSCNGGLRWQIFTWNSGYNYKNTISNACLFQIAARLGRYTGNTTYLDVAERVFDWLVGVGYIVLSEKGNVYDGAKVEDNCTDITAIEWTYNHGVVLGGLAYMYNATNGSSVWQSRLTSVLGGATAYFFQDDIMYESACQPYKTCNNDQRCFKSIFSRMLGFTSVLAPFTSDTIDPLLKASAMAAAGSCDGGTDGHTCGLDWQLKTNDGYYGLGEQMSALEVIQQLLIHERPAPYRADNGGTSVGDAAAGLNSTTTNVLKNNLKITGGDRAGAAIVTTIVLGIIIGGAAWMMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJP8</accession>
    <name>Q6FJP8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0M04565g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJP8"/>
    <dbReference type="SMR" id="Q6FJP8"/>
    <dbReference type="FunCoup" id="Q6FJP8">
        <property type="interactions" value="237"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJP8"/>
    <dbReference type="CAZy" id="GH81">
        <property type="family name" value="Glycoside Hydrolase Family 81"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891555"/>
    <dbReference type="CGD" id="CAL0137433">
        <property type="gene designation" value="CAGL0M04565g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04565g"/>
    <dbReference type="eggNOG" id="KOG2254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005482_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FJP8"/>
    <dbReference type="OMA" id="YIQMIHA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000006">
        <property type="entry name" value="Endo-1,3-beta-glucanase Engl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1170">
        <property type="entry name" value="glycoside hydrolase family 81 endo-[beta] glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040451">
        <property type="entry name" value="GH81_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03639">
        <property type="entry name" value="Glyco_hydro_81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 N-terminal" evidence="10">
        <location>
            <begin position="94"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="11">
        <location>
            <begin position="415"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0137433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG62522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="770" mass="86565" checksum="3F64C89FE86747F3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJR8</accession>
    <name>Q6FJR8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M04125g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449526.1">
        <property type="nucleotide sequence ID" value="XM_449526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJR8"/>
    <dbReference type="FunCoup" id="Q6FJR8">
        <property type="interactions" value="666"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJR8"/>
    <dbReference type="ESTHER" id="canga-q6fjr8">
        <property type="family name" value="ABHD13-BEM46"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.A35"/>
    <dbReference type="KEGG" id="cgr:2891535"/>
    <dbReference type="CGD" id="CAL0137287">
        <property type="gene designation" value="CAGL0M04125g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04125g"/>
    <dbReference type="eggNOG" id="KOG4391">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FJR8"/>
    <dbReference type="OMA" id="QYWTSED"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="89"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="290" mass="33164" checksum="B3B52FDDE9AA7FB0" modified="2004-07-19" version="1">MLYRTFKMIFGGVLALGTISVTAVYLVQNKLVYPSWAQGAREYVDTPASKNIPYKEVTLTTKDGIELQAWDIRNEETKSKSTVLILCPNAGNIGYFIPIIDIFYSQFGLNVFIYSYRGYGYSKGTPSEEGLKIDADRVMSYLATDDFHKTKKLILYGRSLGGANAIYIASKFSQLCDAVILENTFLSIRKVIPYIFPWISRFAFMCHEVWNSEEDMPHCNSEIPYLFLSGLEDEIVPPEHMKDLYDICPSGSKQIYEFPFGTHNTTIIQDGYWEIVRKFLEDNKFIEPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJT0</accession>
    <name>Q6FJT0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S ribosomal protein L25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0M03861g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJT0"/>
    <dbReference type="FunCoup" id="Q6FJT0">
        <property type="interactions" value="881"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJT0"/>
    <dbReference type="KEGG" id="cgr:2891621"/>
    <dbReference type="CGD" id="CAL0137289">
        <property type="gene designation" value="CAGL0M03861g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03861g"/>
    <dbReference type="eggNOG" id="KOG1751">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJT0"/>
    <dbReference type="OMA" id="RLDHHKV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="9">
        <location>
            <begin position="3"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0137289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="142" mass="15704" checksum="620BF9BFB30AA807" modified="2004-07-19" version="1">MAPSAKASAAKKAVVKGTNGKKALKTRTSATFRLPKTLKLARSPKYASKSVPHYNRLDSYKVIEHPITSETAMKKVEDGNILVFQVSLKANKHQIKKAVKELYEVDVMKVNTLITAKGNKKAFVRLTADYDALDIANRIGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJX0</accession>
    <name>Q6FJX0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin domain-containing protein DSK2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0M02937g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJX0"/>
    <dbReference type="FunCoup" id="Q6FJX0">
        <property type="interactions" value="740"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJX0"/>
    <dbReference type="KEGG" id="cgr:2891482"/>
    <dbReference type="CGD" id="CAL0137101">
        <property type="gene designation" value="CAGL0M02937g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02937g"/>
    <dbReference type="eggNOG" id="KOG0010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024293_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJX0"/>
    <dbReference type="OMA" id="PGMDMFG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="327"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0137101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="39845" checksum="25AF840E93EECF43" modified="2004-07-19" version="1">MSITIHIKSGQNKWDVSIDPSQTILNLKEEIAKVSEIPSGNQRLIYSGKILKDDQTVESYNIKDDHAIHMVKSGGNASTSNAPTNANESSNSSTTAVPSNIASGQTGGFNPLADLTGARYAGYANLPSADMFGPDGGINNAPDQDEMLRMMENPIFQSQMNEMLSNPEMLDFMIQSNPQLQAMGPQARQMLQSPFFRQMLTNPAMIRQSMQFARMMNGQGGMPGADATDASAFPAPGGDDTETTTGSTENTSTNNRTNSNANANPNAAANPFAALMDPASNPFAAMMGNMNNQQGGAGVQQPAFDPTLLASLLGGQLPAPAQEDNRPPEERYEQQLRQLNDMGFFDFDRNVAALRRSGGSVQGALDALLNGDV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK56</accession>
    <name>ATG23_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATG23</name>
        <name type="ordered locus">CAGL0M00968g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for cytoplasm to vacuole transport (Cvt) vesicle formation and efficient autophagy. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9. Also plays a role in regulation of filamentous growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449388.1">
        <property type="nucleotide sequence ID" value="XM_449388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK56"/>
    <dbReference type="SMR" id="Q6FK56"/>
    <dbReference type="FunCoup" id="Q6FK56">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK56"/>
    <dbReference type="EnsemblFungi" id="CAGL0M00968g-T">
        <property type="protein sequence ID" value="CAGL0M00968g-T-p1"/>
        <property type="gene ID" value="CAGL0M00968g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891157"/>
    <dbReference type="KEGG" id="cgr:2891157"/>
    <dbReference type="CGD" id="CAL0137259">
        <property type="gene designation" value="CAGL0M00968g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00968g"/>
    <dbReference type="eggNOG" id="ENOG502RZQ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051067_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK56"/>
    <dbReference type="OMA" id="DLCRIND"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000064724" description="Autophagy-related protein 23">
        <location>
            <begin position="1"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="32"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="183"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="274"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="440" mass="50457" checksum="B6728C7C6E5A9381" modified="2004-07-19" version="1">MLNDILVEVAEKTQLLESLIIPHERALTESDYSDQLENIRAEISATLNSLSNLNDLLISHDGPLRTEISSLMASKSKLKKINMKELTLLNEQETLETLRNDSSNLESSRPGFTTQQQQSITIASSYRHELQKYLDLVDVEKTSLNTNKLADNSKISKEDVENSDFNFNLKRYEKQQSILHSALTVNEIEIKKLETLLKEFRKDNNFIRDELKLINSNLKSHEDLISDELKQIDESRYAIMQSIGYSGRNEQQSSILDSIVKLSIKKPDIRTLIQERIEEYSNLLNFIDMKLNGLDQMLQEYKSRKSEWAEKSILWSQCLALISELEVTVRDQLSSAHTVGSEISPDQIKAQIKKFLTKLNKLLDESDLEDVVYSLVRNEVNSLNVALDEMNQMPQIKNDISDRESIHNPSFKLISKSPPKTGFSSENVSYKLNNTNIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK99</accession>
    <name>Q6FK99_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0L13244g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK99"/>
    <dbReference type="FunCoup" id="Q6FK99">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK99"/>
    <dbReference type="KEGG" id="cgr:2890595"/>
    <dbReference type="CGD" id="CAL0135608">
        <property type="gene designation" value="CAGL0L13244g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L13244g"/>
    <dbReference type="eggNOG" id="ENOG502QR1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050572_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK99"/>
    <dbReference type="OMA" id="VMAYYTF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06903">
        <property type="entry name" value="lectin_EMP46_EMP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016710">
        <property type="entry name" value="Emp46/Emp47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035661">
        <property type="entry name" value="EMP46/EMP47_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018136">
        <property type="entry name" value="L-type_lectin_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273433" description="L-type lectin-like domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="29"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018136-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0135608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="447" mass="50771" checksum="C7E915BFD2507B2F" modified="2004-07-19" version="1">MKFGSILTGLLASSAVYAHGTDSHGSKTDKEKLDLEYSLPELVKLNDKLPAHWRTSDATKLEAGRFILTPTKNSKGSLWLKKSFNLETSFTIEWTFRDVGFEGDSKAAMAFWFVTGSSEQEIDETLKDKSMVNGPSKFDGLMLHLDTNEVHGPSIRAQLNDKITAFTPEIVHEKSFGSCLLAYQDSAVPTTARLTYDKDNKSMLKLQIDNRVCFQTFKVKLPQGLYRFGVTAVNDNNAESFEILKMHAYNGVVEDSLIPNSNPMPQPKFVTKQIDKDTGKEKIVEQDIFDTKKGNSISTLDLYKKLDSVEGRLLANDISVLDKKLDELIGLEKEATDFILQMVGLLDIIVKKRSEVFNQSDENKEQADAIEKEKFKDFLSLNDKLESLYEEQIRIREATQKANSSKQDVDTLLWKISLWIFPLIVIMLIMTYYTFKIRQEIIKTKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKE8</accession>
    <name>Q6FKE8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bud site selection protein RAX2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0L12144g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKE8"/>
    <dbReference type="FunCoup" id="Q6FKE8">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKE8"/>
    <dbReference type="KEGG" id="cgr:2890686"/>
    <dbReference type="CGD" id="CAL0135456">
        <property type="gene designation" value="CAGL0L12144g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12144g"/>
    <dbReference type="eggNOG" id="ENOG502QQZD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005863_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKE8"/>
    <dbReference type="OMA" id="NMYTPGC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005621">
        <property type="term" value="C:cellular bud scar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902929">
        <property type="term" value="C:plasma membrane of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007120">
        <property type="term" value="P:axial cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007121">
        <property type="term" value="P:bipolar cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024982">
        <property type="entry name" value="Rax2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048266">
        <property type="entry name" value="Rax2-like_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048265">
        <property type="entry name" value="Rax2-like_third"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31778:SF2">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN RAX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12768">
        <property type="entry name" value="Rax2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20842">
        <property type="entry name" value="Rax2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20843">
        <property type="entry name" value="Rax2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like second" evidence="3">
        <location>
            <begin position="208"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like third" evidence="4">
        <location>
            <begin position="386"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Rax2-like C-terminal" evidence="2">
        <location>
            <begin position="851"/>
            <end position="1051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0135456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1156" mass="127568" checksum="2AAF1D346302B20E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKL4</accession>
    <name>Q6FKL4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G1/S-specific cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0L10648g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDC28 protein kinase to form MPF.</text>
    </comment>
    <comment type="function">
        <text evidence="6">G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKL4"/>
    <dbReference type="FunCoup" id="Q6FKL4">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKL4"/>
    <dbReference type="KEGG" id="cgr:2891041"/>
    <dbReference type="CGD" id="CAL0135974">
        <property type="gene designation" value="CAGL0L10648g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10648g"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_536434_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKL4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000080">
        <property type="entry name" value="G1/S-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014399">
        <property type="entry name" value="Cyclin_CLN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21615">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21615:SF2">
        <property type="entry name" value="CYCLIN N-TERMINAL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001770">
        <property type="entry name" value="Cyclin_CLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 6 7" id="KW-0195">Cyclin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="9">
        <location>
            <begin position="75"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="434"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0135974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="476" mass="54587" checksum="B0BB0A8FF338ED8F" modified="2004-07-19" version="1">MSNSNCGLKVTAKQTYYPIELSNAELLTHYETIQEYHNDISENVLRTAAKFKPDTKMIDMQPQMNPNETRSTMVNFLFELSVLTRVTNGIFFHSVRLYDRYCSKRVILRDQANLVAGTCLWLAAKTWGGCSHVINNVTVPTGGRFYGPNPRARVPRLSELVHYCGGSEVFDESMFMQMERHILDTLNWDVYEMSINDYVLNVDENCLIQYELYEAQLKYSREMKMKHNSGASKSTIDMTEDDEEYNELRMKIELINLKKFLIDLSCWNYKFLKAEMHELCQSIFDTINRFTSQDQGPLLSIPSLNPETSEELINVFVETIVNLPDSIFRVYKDQTGVFEFVVKVREYNDEMQRKYQAPSIMDLSKRLAINTQYVDIESGVPSPAYSTDTLTPMRHSSAQSDNSVFSVNHLGNSSPLTPHMHSFTNFKNDSAHCSSTSLSSIPNDNRANAGMNNYSIASTNKPTHMDYDNKENQLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKT8</accession>
    <name>Q6FKT8_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L08756g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKT8"/>
    <dbReference type="FunCoup" id="Q6FKT8">
        <property type="interactions" value="1108"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKT8"/>
    <dbReference type="KEGG" id="cgr:2890633"/>
    <dbReference type="CGD" id="CAL0135914">
        <property type="gene designation" value="CAGL0L08756g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08756g"/>
    <dbReference type="eggNOG" id="KOG1248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003753_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKT8"/>
    <dbReference type="OMA" id="PDQMKHR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="24"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="365"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1033"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1169"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1205"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1219" mass="137058" checksum="7C3EAA456B581DC3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKY4</accession>
    <name>Q6FKY4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GLO1</name>
        <name evidence="11 12" type="ordered locus">CAGL0L07656g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449110.1">
        <property type="nucleotide sequence ID" value="XM_449110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKY4"/>
    <dbReference type="SMR" id="Q6FKY4"/>
    <dbReference type="FunCoup" id="Q6FKY4">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKY4"/>
    <dbReference type="GeneID" id="2890999"/>
    <dbReference type="KEGG" id="cgr:2890999"/>
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        <property type="gene designation" value="GLO1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07656g"/>
    <dbReference type="eggNOG" id="KOG2944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FKY4"/>
    <dbReference type="OMA" id="MGDAWGH"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Lactoylglutathione lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="175"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0135970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG62080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="319" mass="36396" checksum="9F68CF9B7E880FB4" modified="2004-07-19" version="1">MSYPHKIAAAHDDPTLMFNHTCLRIKDPAKSIPFYQKHFGMELLNKLDFPEMKFSLFFLSFPKDNVAKNSEGKNDVFSTSGILELTHNWGSENDADFKICNGNEEPHRGFGHICFSYADINAACSKLEAEGVSFKKRLTDGRMKDIAFALDPDGYWIELIRYDRENSPKKDVGSRFNHTMVRVKDPKASLEFYQNVLGMKLLRTSEHEAAKFTLYFLGYKVSSEDNEFSHEGVLELTHNWGTENEADFKYHNGNDKPQGYGHICVSCKDPAKLCNEIEQTYGDKIQWAPKFNQGKLKNIAFLKDPDGYSIEVVPHGLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKZ4</accession>
    <name>Q6FKZ4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0L07414g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the SMC5-SMC6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NSE4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKZ4"/>
    <dbReference type="FunCoup" id="Q6FKZ4">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKZ4"/>
    <dbReference type="KEGG" id="cgr:2890988"/>
    <dbReference type="CGD" id="CAL0135952">
        <property type="gene designation" value="CAGL0L07414g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07414g"/>
    <dbReference type="eggNOG" id="KOG2866">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041037_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FKZ4"/>
    <dbReference type="OMA" id="NIXENRN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014854">
        <property type="entry name" value="Nse4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08743">
        <property type="entry name" value="Nse4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosome element 4 C-terminal" evidence="9">
        <location>
            <begin position="264"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0135952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="359" mass="40970" checksum="EC590E256C9EF3DC" modified="2004-07-19" version="1">MESEHEVQQLYRDIQNEITVLKTRLSKGGDVAVAQDVYKRAEALFPKVSSLKNNRLFAQDARVVADLSELTQICIRNLDFDDEFSLVSLDDVVQYSKAYMLRDYLQLSGVEVKTEKTFDLSADSDGTGGGTVEGGNDAGGETSDAAPQRPEHISEMLQINKKRKVLRQYDQYTHFTQFNWYRMGTLFNKVSKLPPTTDHLLGPFGFERKKRVLKERAARDGLAEKSTAENLSKETLTSGQEITTPEQVQRCFKILKRKNGMNSINLFQFVLDPNSYSKSVENLFYTSFLLKENKLQMTEGNDGMPEIAIYKHSKDRTNDNNDGQRGRGDHQNHIIFQLDMPTWQKLVAKLGIKEPFLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL04</accession>
    <name>Q6FL04_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0L07194g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449090.1">
        <property type="nucleotide sequence ID" value="XM_449090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL04"/>
    <dbReference type="KEGG" id="cgr:2890835"/>
    <dbReference type="CGD" id="CAL0136202">
        <property type="gene designation" value="CAGL0L07194g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07194g"/>
    <dbReference type="HOGENOM" id="CLU_1686332_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL04"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0136202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="156" mass="18013" checksum="65F67893A87E86A3" modified="2004-07-19" version="1">MASLGDGQLNSISVIYENASVYNSTDYLFQLKRVQLITLALAENPECSSPGSSYQFCQSCLHVRKHFVCTWNTMSDMKRLSSRERIEYFLENLIFLRIAMSIINRKLLSMSQLDAIKSTLGLDLNLTILLYYLNDRGLLVCLVKQIFYSYNYVCIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL16</accession>
    <name>Q6FL16_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L06930g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449078.1">
        <property type="nucleotide sequence ID" value="XM_449078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL16"/>
    <dbReference type="FunCoup" id="Q6FL16">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890823"/>
    <dbReference type="CGD" id="CAL0136100">
        <property type="gene designation" value="CAGL0L06930g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06930g"/>
    <dbReference type="eggNOG" id="KOG4488">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165034_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FL16"/>
    <dbReference type="OMA" id="NRDADIM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0136100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="65" mass="7470" checksum="46405E3C2AAE498A" modified="2004-07-19" version="1">MARGNQRELARQKNLKKQQEAAKHQKKGDAKKRMESDAEILRQKQAAADARKEAERLEKLKAGKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL71</accession>
    <name>AIM23_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM23</name>
        <name type="ordered locus">CAGL0L05698g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449023.1">
        <property type="nucleotide sequence ID" value="XM_449023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL71"/>
    <dbReference type="SMR" id="Q6FL71"/>
    <dbReference type="FunCoup" id="Q6FL71">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0L05698g-T">
        <property type="protein sequence ID" value="CAGL0L05698g-T-p1"/>
        <property type="gene ID" value="CAGL0L05698g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890802"/>
    <dbReference type="KEGG" id="cgr:2890802"/>
    <dbReference type="CGD" id="CAL0135710">
        <property type="gene designation" value="CAGL0L05698g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05698g"/>
    <dbReference type="eggNOG" id="ENOG502RY27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057910_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL71"/>
    <dbReference type="OMA" id="KVSWQIS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029427">
        <property type="entry name" value="AIM23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14877">
        <property type="entry name" value="mIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000399532" description="Altered inheritance of mitochondria protein 23, mitochondrial">
        <location>
            <begin position="42"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="336" mass="38875" checksum="F9B7E23D5563F800" modified="2004-07-19" version="1" precursor="true">MIRSILCCRPVRQFHSSFLSLNSASPALNAGIAIDAWLKRGTAKSNIKNRKKYDHHHNGENRRRKKPMAVRWSSGTERAKEAANHMLSKVFETNSKGNIRFFNQISGKVEDSNIREFAKGIDLSQHGINIVNIINTETEQLPFVKLVDTKTALKKYSDYLAEKKEEELKSMGLLPRKFFENSKTNEDNLKHIKISWSIKEDDLAKQKAHDITSMLKKGNKVNLYIADKEDLGGSKWMENFENVEEEKPPSKKRLRPSEIERRESIIEQLKLLVSDISTDPIIEGRANGKMIIRLTPKVNKDDSIDKRSLKELKKQQRIEKLNKKLQRKKERELQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLB7</accession>
    <name>Q6FLB7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lysophospholipid acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0L04642g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLB7"/>
    <dbReference type="FunCoup" id="Q6FLB7">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLB7"/>
    <dbReference type="KEGG" id="cgr:2890647"/>
    <dbReference type="CGD" id="CAL0135358">
        <property type="gene designation" value="CAGL0L04642g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04642g"/>
    <dbReference type="eggNOG" id="KOG2704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011340_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FLB7"/>
    <dbReference type="OMA" id="WHGTRPG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071618">
        <property type="term" value="F:lysophosphatidylethanolamine acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036151">
        <property type="term" value="P:phosphatidylcholine acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090640">
        <property type="term" value="P:phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0135358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="72277" checksum="95B00CC234B27609" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLG3</accession>
    <name>Q6FLG3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GSH1</name>
        <name evidence="12 13" type="ordered locus">CAGL0L03630g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448931.1">
        <property type="nucleotide sequence ID" value="XM_448931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLG3"/>
    <dbReference type="SMR" id="Q6FLG3"/>
    <dbReference type="FunCoup" id="Q6FLG3">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLG3"/>
    <dbReference type="GeneID" id="2890742"/>
    <dbReference type="KEGG" id="cgr:2890742"/>
    <dbReference type="CGD" id="CAL0135962">
        <property type="gene designation" value="GSH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03630g"/>
    <dbReference type="eggNOG" id="KOG3754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010467_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLG3"/>
    <dbReference type="OMA" id="IAHMFIR"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071585">
        <property type="term" value="P:detoxification of cadmium ion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000006">
        <property type="entry name" value="Glutamate--cysteine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.710">
        <property type="entry name" value="Glutamate cysteine ligase subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0135962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="678" mass="78873" checksum="EEC2652DA32B5077" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLQ0</accession>
    <name>Q6FLQ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4484 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0L01705g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLQ0"/>
    <dbReference type="FunCoup" id="Q6FLQ0">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890885"/>
    <dbReference type="CGD" id="CAL0135016">
        <property type="gene designation" value="CAGL0L01705g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01705g"/>
    <dbReference type="eggNOG" id="KOG4704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019791_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FLQ0"/>
    <dbReference type="OMA" id="AISPCKE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018626">
        <property type="entry name" value="LCHN/Anr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053056">
        <property type="entry name" value="Lipid_Metab_Assoc_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153:SF1">
        <property type="entry name" value="DUF4484 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28153">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09804">
        <property type="entry name" value="DENND11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0135016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="52532" checksum="B0765355787243CD" modified="2004-07-19" version="1">MASHMLTNVFLCQFDMSRGNTLVWSARDNDPLLKGIEFKALPSGIHEVSDDVIRFCIEYEQTQYYGICCYLQNAFEVLDNEGQVDRSKVKMYSLGVIVDPSQISDDLRGFNYEVTNQYIPELQSLLKDWSTNQGSNSNSYEQLSTYYHKKISGSLNYEVDYQTSMLNHLPYWLNKLGPLIFPLFKSCLLRERILVISAPGNSFEYTNSLLYCLATISRNSKLNMGNTGSKGSYIPTLFTVGTYDIEDLEKHGQEGFLAVTSDEILLYKEELFDKALILPSDSLIHEGLELQDNKGHPVKATIHESRIFNKLLETYCDQDITKRDLERFSRNTETMSWLQYILDSMLFLATAGHITARYNETREIIQKSLSREEGEPDEHYDARGIVQFFNSRSDELLDYIQRTIEDSNNILPATITIDLDMDYFSKQDYEFLRMFAKKWLDKDIMFKTNILGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLU3</accession>
    <name>Q6FLU3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L00627g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448801.1">
        <property type="nucleotide sequence ID" value="XM_448801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLU3"/>
    <dbReference type="STRING" id="284593.Q6FLU3"/>
    <dbReference type="KEGG" id="cgr:2890567"/>
    <dbReference type="CGD" id="CAL0135152">
        <property type="gene designation" value="CAGL0L00627g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L00627g"/>
    <dbReference type="eggNOG" id="ENOG502QV98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015198_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLU3"/>
    <dbReference type="OMA" id="GHRMESI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF471">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="95140" checksum="85B861AEAF1B7952" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLY2</accession>
    <name>Q6FLY2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RIM15</name>
        <name evidence="15 16" type="ordered locus">CAGL0K12562g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448762.1">
        <property type="nucleotide sequence ID" value="XM_448762.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FLY2">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLY2"/>
    <dbReference type="GeneID" id="2890417"/>
    <dbReference type="KEGG" id="cgr:2890417"/>
    <dbReference type="CGD" id="CAL0134481">
        <property type="gene designation" value="RIM15"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12562g"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000709_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FLY2"/>
    <dbReference type="OMA" id="HNRRFVG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903452">
        <property type="term" value="P:positive regulation of G1 to G0 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001008">
        <property type="entry name" value="Serine/threonine-protein kinase cek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="782"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1210"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1543"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="610"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="943"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1022"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1289"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1420"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="624"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="672"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="944"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1038"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1307"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1420"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1457"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1469"/>
            <end position="1480"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1488"/>
            <end position="1497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0134481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG61725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1682" mass="189448" checksum="9A987E799AAC3CFC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM26</accession>
    <name>Q6FM26_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0K11550g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM26"/>
    <dbReference type="FunCoup" id="Q6FM26">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM26"/>
    <dbReference type="KEGG" id="cgr:2890521"/>
    <dbReference type="CGD" id="CAL0134381">
        <property type="gene designation" value="CAGL0K11550g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11550g"/>
    <dbReference type="eggNOG" id="KOG0586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032736_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM26"/>
    <dbReference type="OMA" id="PCDMIMS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031138">
        <property type="term" value="P:negative regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016240">
        <property type="entry name" value="Ser/Thr_kin_YKL116c_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000609">
        <property type="entry name" value="Ser/Thr_PK_YKL116c_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="217"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0134381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="538" mass="60629" checksum="E2179BA3123BB329" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM36</accession>
    <name>Q6FM36_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0K11341g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the assembly of the cytochrome c oxidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COX20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM36"/>
    <dbReference type="FunCoup" id="Q6FM36">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890067"/>
    <dbReference type="CGD" id="CAL0134093">
        <property type="gene designation" value="CAGL0K11341g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11341g"/>
    <dbReference type="eggNOG" id="ENOG502S3BD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125578_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM36"/>
    <dbReference type="OMA" id="IVGWEQC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043069">
        <property type="term" value="P:negative regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007871">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="148"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0134093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="185" mass="21128" checksum="4AB19B782255EEF8" modified="2004-07-19" version="1">MWNPFKKSEEKPQVAEDLPTNYTPGQKILLEDTRPKFQSDISKGDVAASKEQASLRAAWESISWNDFTLEKLTSIPCFRDAGMVGFSSMFVTGSVILLYHKNINKAMNWAVGGLMLGSIVGWEQCRMKRKRSFQVAQMAMETVAKKEKPMKHKVEHDPKLLDQWEGRSGLKPNGPSDSKPWYKFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMK0</accession>
    <name>Q6FMK0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate/oxoglutarate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0K07436g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMK0"/>
    <dbReference type="FunCoup" id="Q6FMK0">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMK0"/>
    <dbReference type="KEGG" id="cgr:2890376"/>
    <dbReference type="CGD" id="CAL0134511">
        <property type="gene designation" value="CAGL0K07436g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07436g"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052717_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMK0"/>
    <dbReference type="OMA" id="VMGPCTY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180056">
        <property type="term" value="F:citrate:2-oxoglutarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000053">
        <property type="entry name" value="Mitochondrial DNA replication protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000085">
        <property type="entry name" value="Tricarboxylate carrier, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053017">
        <property type="entry name" value="Mito_Cit/Oxoglu_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982">
        <property type="entry name" value="CITRATE/OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46982:SF1">
        <property type="entry name" value="CITRATE_OXOGLUTARATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="12"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="206"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33587" checksum="1A5859ADDBA74C47" modified="2004-07-19" version="1">MAQTIEKKPVSFSNILLGAGLNLSEVTTLGQPLEVVKTTMAAHREFNFLQATKHVWSRGGIFGFYQGLIPWAWIEASTKGAVLLFVSAEAEYRFKVLGLNNFGAGIMGGITGGVTQAYLTMGFCTCMKTVEITRQKAANVPGVIPQSSWQVFKSIYKKEGIRGINKGVNAVAIRQMTNWGSRFGLSRLVEDGIRKLTGKTGKDDKLTALEKIMASAIGGGLSAWNQPIEVIRVEMQSKKEDPNRPKNLTVGKTFKYIYQSNGLKGLYRGVTPRVGLGIWQTVFMVGFGDMAREFVAKLTGEKPAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMM8</accession>
    <name>Q6FMM8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YAP1-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">YBP1</name>
        <name evidence="1 2" type="ordered locus">CAGL0K06743g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448516.1">
        <property type="nucleotide sequence ID" value="XM_448516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMM8"/>
    <dbReference type="FunCoup" id="Q6FMM8">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMM8"/>
    <dbReference type="GeneID" id="2890404"/>
    <dbReference type="KEGG" id="cgr:2890404"/>
    <dbReference type="CGD" id="CAL0134527">
        <property type="gene designation" value="YBP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06743g"/>
    <dbReference type="eggNOG" id="ENOG502QWJN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024514_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMM8"/>
    <dbReference type="OMA" id="TYEIGWD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040347">
        <property type="entry name" value="YBP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020:SF1">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0134527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="75429" checksum="7E5DB30EDBC7AF13" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN29</accession>
    <name>Q6FN29_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K03223g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
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                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="eggNOG" id="KOG0937">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="MHD"/>
    </dbReference>
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        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
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    </dbReference>
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        <property type="entry name" value="SNARE-like"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="597"/>
        </location>
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        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0133875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="598" mass="69620" checksum="D4EAD53A4D80CA9A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN98</accession>
    <name>Q6FN98_CANGA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K01639g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="cgr:2890022"/>
    <dbReference type="CGD" id="CAL0134031">
        <property type="gene designation" value="CAGL0K01639g"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_649055_0_0_1"/>
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        <property type="component" value="Chromosome K"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="403" mass="45724" checksum="C36C0206E4430470" modified="2004-07-19" version="1">MLINTVSVIAQRNNTSATSKFHIAYKNMLSRFSGIATRNPLRASSLILKGLPNRNAKIVQLLSLTSVTRSTQSLPALRSSNQLLTIPPCQPRTLNKVLKRGFYTTSKKSIKFIFSKGDKDNHNKMKYYSIPTPVVILSTIGGFVLLFTILPFLFTFGFPFLIGMIVFFQFRRWKTHQLYKKMAEVLQDSQINMKNNQLMSLKYRLIEQGLPMLTNFSNKTTKQLSSRGETLINQLQQRIKESFANNDNNIANVFVPQGHKLSEYELLLPHHTFKSYTKKLPHDQDIGLLSLSLYMRRRQHRNIKVAMPIPVELNLGNKVANVYFVYKGDTARGLLNTQILLEAAKAGVDLQEIKSSTQFLISIVPLDSWLPTQYIIADAGSLGSFNEDPSSSSREFVINNKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNM2</accession>
    <name>Q6FNM2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PSP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J10582g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNM2"/>
    <dbReference type="KEGG" id="cgr:2889610"/>
    <dbReference type="CGD" id="CAL0133400">
        <property type="gene designation" value="CAGL0J10582g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10582g"/>
    <dbReference type="eggNOG" id="ENOG502QWA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032585_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNM2"/>
    <dbReference type="OMA" id="FKLFWEL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="52083" checksum="CBCD6DA881DA8779" modified="2004-07-19" version="1">MSKKLSLEEFLGDGILGESVWNEDEINLDAINNTTNLDILKTKSTEHGNARTPHFGPGMNGPGGPGGSSGSMQSPSMGGRVHAPPTNVNPNADYVVTGPPYIIKFSNLPPRFSEFDIKDLFQAKSTQYVKFKLFWELNKNPSIDTMKNGTVFEKNFKKNWKVAFVELFTARDMDKILKFWSTPLKELYNILLTPGEFPDFKEYIAKATLITDPNDDPAKPHLEKELELQKEEKLKEKKTSPVPTTNKPSYSQILEKSLNSPSPAATPLSGGSSVINQSGHTMQHGDNLSKYSKHETNDSDDELSKNFEDKVNFDDNQSSSNDNNDGSQAGSYNGNYNNYKRGSSRGSYNRGGRGNFNGRGGNRGGYNSRGNFNNRGGYHNRDGANKDQQRTNSYGNRQDRKDNYSKNDDERSNSNKSDNDSLSGLFKPASDFLRGSDDRNSSRGDRGRGGRGSHRGGRFSTRGQGTNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNM3</accession>
    <name>Q6FNM3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Monopolin complex subunit LRS4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J10560g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNM3"/>
    <dbReference type="FunCoup" id="Q6FNM3">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNM3"/>
    <dbReference type="KEGG" id="cgr:2889609"/>
    <dbReference type="CGD" id="CAL0132858">
        <property type="gene designation" value="CAGL0J10560g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10560g"/>
    <dbReference type="eggNOG" id="ENOG502S5I1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080754_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNM3"/>
    <dbReference type="OMA" id="YESVIEC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018479">
        <property type="entry name" value="Lrs4/Mde4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10422">
        <property type="entry name" value="LRS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34217" checksum="3D179BEDB1FD140A" modified="2004-07-19" version="1">MALQVVADYYRCVLENERIYYEYQLNRRETVKNSRSEDEFSGSERTNALKTDEQLQLQRQVNKLTVDLQSMAHENERLREFQKTQKQILESKIQQLKKTVDSFKNERNSSSSSHVRTPPRQTRSGAYTQGKDTDLSRRGGFHLLSPIVGNVNPGKEKAGGLKETLKVGRNTIFDKNSSLLDDDDDDDDDEINGTSVKERSRVTGRKLRSSSSLKDSKNNHIEEEEAMEFTTDNSDEVGLMEGLKLRDGSAKANLQLPSGSLSPDEDTQSSNEETTNTRKKRRRLTRRRIQTMNSDNSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNV0</accession>
    <name>Q6FNV0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J08866g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNV0"/>
    <dbReference type="FunCoup" id="Q6FNV0">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNV0"/>
    <dbReference type="KEGG" id="cgr:2889680"/>
    <dbReference type="CGD" id="CAL0133102">
        <property type="gene designation" value="CAGL0J08866g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08866g"/>
    <dbReference type="eggNOG" id="ENOG502S4WG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107237_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNV0"/>
    <dbReference type="OMA" id="NARNWDN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25940" checksum="3A933E084C5763BC" modified="2004-07-19" version="1">MSDLNTVYEHIRRAEQKCRSGDLSDALDLYVSALEGLDLKSPNFDLQGLDDTIIEAVKLLRDDIQLRIKELQICVIESSKDEKDSKNNKASMALVQSSAGNNNNLAASKYWDSTRNITDITSSTFIDPYTSSMLSKLQNSMVDLIKEAKNQKTDVNDLVSTALFQIDQFKKEMLIYEQRRTREYQIKVEHLNKDVKKLSSQNSKLKERWDSLVESARQRKNRQQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNW3</accession>
    <name>Q6FNW3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Tricalbin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0J08591g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
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                <person name="Jauniaux N."/>
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                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
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                <person name="Nicaud J.M."/>
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                <person name="Ozier-Kalogeropoulos O."/>
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    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="12">
        <location>
            <begin position="57"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="685"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0132894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG60995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="788" mass="89322" checksum="3152C992322B6A6E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP44</accession>
    <name>Q6FP44_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J06776g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP44"/>
    <dbReference type="FunCoup" id="Q6FP44">
        <property type="interactions" value="1134"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP44"/>
    <dbReference type="KEGG" id="cgr:2889554"/>
    <dbReference type="CGD" id="CAL0129863">
        <property type="gene designation" value="CAGL0J06776g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06776g"/>
    <dbReference type="eggNOG" id="KOG1993">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003886_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP44"/>
    <dbReference type="OMA" id="SFHYVFH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF7">
        <property type="entry name" value="IMPORTIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0129863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1027" mass="118672" checksum="15FA4B33EE7C27E2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP82</accession>
    <name>Q6FP82_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0J05896g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP82"/>
    <dbReference type="FunCoup" id="Q6FP82">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889771"/>
    <dbReference type="CGD" id="CAL0133250">
        <property type="gene designation" value="CAGL0J05896g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05896g"/>
    <dbReference type="HOGENOM" id="CLU_1421249_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP82"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10333">
        <property type="entry name" value="Pga1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274128" evidence="2">
        <location>
            <begin position="20"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="191" mass="21681" checksum="2C90ABA9958F66ED" modified="2004-07-19" version="1">MLLYYTVLPVLWLCAIVSANTETLRIRIPRQFKTSELTRQVHDSYSILKNLEDTAIVSGNINSTSPFHVIEVRSNWSGTTLDVRVSWTAADGYSINDLGYLLITKEHEVVTPWSNETFEGLHEKLYVYFKVVPDSYPLLEDGQVFNVAINIKETFLGLTSDLYVMIAYLIVLASISRLVVVHGWKLLSPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP88</accession>
    <name>Q6FP88_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0J05764g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP88"/>
    <dbReference type="FunCoup" id="Q6FP88">
        <property type="interactions" value="870"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP88"/>
    <dbReference type="KEGG" id="cgr:2889805"/>
    <dbReference type="CGD" id="CAL0133468">
        <property type="gene designation" value="CAGL0J05764g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05764g"/>
    <dbReference type="eggNOG" id="KOG1781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FP88"/>
    <dbReference type="OMA" id="PFVQQEE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0133468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="117" mass="13035" checksum="CA6F8883B4F29337" modified="2004-07-19" version="1">MSEQNTQQAEQNNNNRGQQKKKFEAPKREAIVDLGKYKDSKVSVKLMGGRIVTGILKGYDQLMNLVLEETEETLKPEVETGATQQVTRQLGLTVIRGTILISLSPLDGSEVLYIQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPA1</accession>
    <name>Q6FPA1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS13m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0J05478g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPA1"/>
    <dbReference type="FunCoup" id="Q6FPA1">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPA1"/>
    <dbReference type="KEGG" id="cgr:2889482"/>
    <dbReference type="CGD" id="CAL0133188">
        <property type="gene designation" value="CAGL0J05478g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05478g"/>
    <dbReference type="eggNOG" id="KOG3311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_2_3_1"/>
    <dbReference type="InParanoid" id="Q6FPA1"/>
    <dbReference type="OMA" id="MNVKRLM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000001">
        <property type="entry name" value="30S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000004">
        <property type="entry name" value="Small subunit ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0133188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="126" mass="14149" checksum="269EDA067B6B7BF3" modified="2004-07-19" version="1">MVVHILGKAFKGKEVIRIALASKFYGVGKSTAERLCSKLGFYPWMRMHQLSEPQILNITSELSNMTIEGDARAIVRENIALKKKIGSYEGMRHALGLPVRGQRTRNNAKTARKINRIGVRAFHTAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2025-06-18" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPB2</accession>
    <name>GPI7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>GPI ethanolamine phosphate transferase 2</fullName>
            <ecNumber>2.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Glycosylphosphatidylinositol-anchor biosynthesis protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">LAS21</name>
        <name type="synonym">GPI7</name>
        <name type="ordered locus">CAGL0J05236g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text>Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447932.1">
        <property type="nucleotide sequence ID" value="XM_447932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPB2"/>
    <dbReference type="SMR" id="Q6FPB2"/>
    <dbReference type="FunCoup" id="Q6FPB2">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPB2"/>
    <dbReference type="GlyCosmos" id="Q6FPB2">
        <property type="glycosylation" value="6 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0J05236g-T">
        <property type="protein sequence ID" value="CAGL0J05236g-T-p1"/>
        <property type="gene ID" value="CAGL0J05236g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889505"/>
    <dbReference type="KEGG" id="cgr:2889505"/>
    <dbReference type="CGD" id="CAL0132810">
        <property type="gene designation" value="LAS21"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05236g"/>
    <dbReference type="eggNOG" id="KOG2125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004770_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPB2"/>
    <dbReference type="OMA" id="SWNQTGQ"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000246194" description="GPI ethanolamine phosphate transferase 2">
        <location>
            <begin position="1"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="578"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="842" mass="95770" checksum="7072063051B0DFC2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPE1</accession>
    <name>Q6FPE1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0J04532g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447903.1">
        <property type="nucleotide sequence ID" value="XM_447903.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FPE1">
        <property type="interactions" value="1014"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPE1"/>
    <dbReference type="KEGG" id="cgr:2889641"/>
    <dbReference type="CGD" id="CAL0133624">
        <property type="gene designation" value="CAGL0J04532g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04532g"/>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FPE1"/>
    <dbReference type="OMA" id="KVEYEMK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23827">
        <property type="entry name" value="RWD_YLR419W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="6">
        <location>
            <begin position="422"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="604"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="838"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0133624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1420" mass="161989" checksum="18338986723B4759" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPH1</accession>
    <name>Q6FPH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0J03872g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPH1"/>
    <dbReference type="FunCoup" id="Q6FPH1">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPH1"/>
    <dbReference type="KEGG" id="cgr:2889660"/>
    <dbReference type="CGD" id="CAL0133368">
        <property type="gene designation" value="CAGL0J03872g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03872g"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002888_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FPH1"/>
    <dbReference type="OMA" id="PPLRRMH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="44"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="438"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="586"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="586"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0133368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="661" mass="74755" checksum="CCA17EAC686472D3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPI2</accession>
    <name>Q6FPI2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor BUD31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J03630g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPI2"/>
    <dbReference type="FunCoup" id="Q6FPI2">
        <property type="interactions" value="997"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPI2"/>
    <dbReference type="KEGG" id="cgr:2889682"/>
    <dbReference type="CGD" id="CAL0132976">
        <property type="gene designation" value="CAGL0J03630g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03630g"/>
    <dbReference type="eggNOG" id="KOG3404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087132_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FPI2"/>
    <dbReference type="OMA" id="FGTSCIC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0132976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17334" checksum="DE46DC15AA23179C" modified="2004-07-19" version="1">MKVKGYERVEPVLAEFERRLKEIGKDKSKSLGKGQGKEDLWRIVQIHSERSRYVYTMYYKRRAISRELYEWLLKKKVADRRLIAKWRKRGYEKLCCLQCVQQSETNHGSTCICRVPRLQLEAEAEKKGVPVSFKECVNCGCHGCASTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ38</accession>
    <name>Q6FQ38_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Target of rapamycin complex 2 subunit BIT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I09416g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ38"/>
    <dbReference type="FunCoup" id="Q6FQ38">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ38"/>
    <dbReference type="KEGG" id="cgr:2888929"/>
    <dbReference type="CGD" id="CAL0129638">
        <property type="gene designation" value="CAGL0I09416g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09416g"/>
    <dbReference type="eggNOG" id="ENOG502RZ40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037144_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ38"/>
    <dbReference type="OMA" id="WSQVGFQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="64042" checksum="F7E5091DBAF71128" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ64</accession>
    <name>Q6FQ64_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0I08811g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447630.1">
        <property type="nucleotide sequence ID" value="XM_447630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ64"/>
    <dbReference type="KEGG" id="cgr:2889000"/>
    <dbReference type="CGD" id="CAL0129446">
        <property type="gene designation" value="CAGL0I08811g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08811g"/>
    <dbReference type="HOGENOM" id="CLU_723791_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ64"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0129446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="354" mass="41273" checksum="088628B11C897145" modified="2004-07-19" version="1">MSKGNLSFIIRVLLERQAGTVNGLKLVRRRVVVMVCSSLLLLIRRIKNSGGMSKIDIRNWCLNTIAVLFATNASPYIKPILDNKKYDKLIDRITLIFSIMISRTVPEKLVSFSVANVIINGIRNFISAKKPDATASSLLNHAATSMLITLIYLLDDKKSRLYKSIIFNDKNLFYDFAIIFSTISIHSFYMDVMNKLGSKKIDKDFLLELYERRKTYRKYKANYSEISNNSKVIVDKFREKYEITFKRQRTKLEKILNSRLFQNFISTSQWCIFKVLLMHIFRKESGRFRFNGTTKKFVATFISLLTLDFGKVMSVNTWILKLLTYYISIKYYHWWQVTEEINKVVLSIASALIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQC1</accession>
    <name>Q6FQC1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0I07469g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQC1"/>
    <dbReference type="FunCoup" id="Q6FQC1">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQC1"/>
    <dbReference type="KEGG" id="cgr:2888972"/>
    <dbReference type="CGD" id="CAL0132106">
        <property type="gene designation" value="CAGL0I07469g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07469g"/>
    <dbReference type="eggNOG" id="KOG2278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052998_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FQC1"/>
    <dbReference type="OMA" id="RHGASQM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.970:FF:000002">
        <property type="entry name" value="Tpt1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0132106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="230" mass="26364" checksum="C5BB7BB6DE095A41" modified="2004-07-19" version="1">MSSKRDIQISKALSYLLRHGAVKENLPFDVNGYIEVERVLNHQRLKSHKCTLEDLHRVVDTNDKKRFNIKLSDDGQTELICAVQGHSIDRIKPDEEVLEVIDTAEKLPKNIIHGTSVRNAIQILKSGSIKRMNRNHIHLSIGITEKDKEVISGMRKSSRVHIYILSEPKILEHLKLYRSMNSVILTPDDINKSLFLLVKIRAASGSDESKDERELINLLDENGIKHEYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQG5</accession>
    <name>Q6FQG5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0I06402g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQG5"/>
    <dbReference type="FunCoup" id="Q6FQG5">
        <property type="interactions" value="1055"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQG5"/>
    <dbReference type="KEGG" id="cgr:2889161"/>
    <dbReference type="CGD" id="CAL0132222">
        <property type="gene designation" value="CAGL0I06402g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06402g"/>
    <dbReference type="eggNOG" id="KOG0739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_1"/>
    <dbReference type="InParanoid" id="Q6FQG5"/>
    <dbReference type="OMA" id="IEWTNEF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990621">
        <property type="term" value="C:ESCRT IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090148">
        <property type="term" value="P:membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036258">
        <property type="term" value="P:multivesicular body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02678">
        <property type="entry name" value="MIT_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19521">
        <property type="entry name" value="RecA-like_VPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000015">
        <property type="entry name" value="vacuolar protein sorting-associated protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000014">
        <property type="entry name" value="Vacuolar protein-sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045253">
        <property type="entry name" value="VPS4_MIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vps4_C"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="11">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="161"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0132222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="432" mass="47826" checksum="94E25D3A82CD32D1" modified="2004-07-19" version="1">MSTGDFLSKGIDLVQKAIEYDTATQYEEAYTAYYNGLDYLMLALKYEKNPKSKELIRAKFTEYLQRAEQLKQHLDEEQEAKKKESTSVGAGSGSGSGSGKDDEDTEDGKKLRGALSGAILSEKPNVKWEDVAGLEGAKEALKEAVILPVKFPHLFKGNRKPTSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWMGESEKLVKQLFTMARENKPSIIFIDEVDALTGQRGEGESEASRRIKTELLVQMNGVGNDSHGVLVLGATNIPWQLDSAIRRRFERRIYIPLPDVAARTKMFEINVGETPCSLTKEDYRNLGQMTDGYSGSDIAVAVKDALMEPIRKIQGATHFRDISDDPDHRKLTPCSPGDEGAIEMSWTDIEADELEEPVLTIKDFLKAIKNTRPTVNEEDLKKQEDFTKDFGQEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQK8</accession>
    <name>Q6FQK8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein MPE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0I05456g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQK8"/>
    <dbReference type="FunCoup" id="Q6FQK8">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQK8"/>
    <dbReference type="KEGG" id="cgr:2889268"/>
    <dbReference type="CGD" id="CAL0132460">
        <property type="gene designation" value="CAGL0I05456g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05456g"/>
    <dbReference type="eggNOG" id="KOG0314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019105_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQK8"/>
    <dbReference type="OMA" id="NVPDHEP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0132460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="50835" checksum="430125C524FB9C60" modified="2004-07-19" version="1">MSSTIFYRFRSQKDSSRVLFDGTGLTVFDLKREIILDNKLGDGTDFQLRVYNPDTDEEYEDDAQVIPRSTTVVVRRSPAAKTFSIHSRNKGGLAATMGNATRYITGRPRVFQQQAGGSIQPQQQQRAGSEAAAVSGMTEEERIASMFATQENQWEQAQQEMSTATPVMSKPITSGANAENDGPPPPGYMCYRCGSRNHWINNCPTNTDPNFEGKRIRRTTGIPKTFLKSVEVNPETMTPQEMAEKKIMVTDEGKFVVQVADKQSWEDYQRKIKNRLIDSDAAIYQPGHFSDLPEELKCNLTGGLLKQPVRTTACCDKLVSKKIMEDTLLDSDFVCPLCDKEDVLLDSLVEDEEIQKKVNEFLKDHEDQNENSKRKADGQTDNGEAKKAKVDENEINSETLNSSAVNSPEKKNESPQKPLPMPIPPVPFGMPAFPMPFMPFMPPQQNSNQNSSNQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2025-06-18" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQL6</accession>
    <name>KAPR_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>cAMP-dependent protein kinase regulatory subunit</fullName>
            <shortName>PKA regulatory subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PKAR</name>
        <name type="ordered locus">CAGL0I05236g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQL6"/>
    <dbReference type="SMR" id="Q6FQL6"/>
    <dbReference type="FunCoup" id="Q6FQL6">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQL6"/>
    <dbReference type="EnsemblFungi" id="CAGL0I05236g-T">
        <property type="protein sequence ID" value="CAGL0I05236g-T-p1"/>
        <property type="gene ID" value="CAGL0I05236g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889197"/>
    <dbReference type="CGD" id="CAL0132356">
        <property type="gene designation" value="BCY1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05236g"/>
    <dbReference type="eggNOG" id="KOG1113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018310_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FQL6"/>
    <dbReference type="OMA" id="WSPPHHP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010603">
        <property type="term" value="P:regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000118">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0114">cAMP</keyword>
    <keyword id="KW-0116">cAMP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000205405" description="cAMP-dependent protein kinase regulatory subunit">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dimerization and phosphorylation" evidence="2">
        <location>
            <begin position="27"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site">
        <location>
            <begin position="170"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <begin position="288"/>
            <end position="404"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="404" mass="44964" checksum="83A09309536B9D14" modified="2004-07-19" version="1">MVSEECRSGLAAFQTAVNENSPDDFFQYGANYFNKKLEEQRKLSRRSAVSGFKSPFASSDPHAKESDNGLFKNSFGSGPFGGNDDPKSNSNSNDSGNGMRSQGQGPTDRNSPEALGNAPIPNNFNALRRTSVSGETLQPDHFDDWQPEHYKEKSEEQLKRLEKSIGKNFLFNKLDSDSKKLVINCLEEKRVSKGTEIIKQGDEGDYFYVVETGTVEFFVNNEKVNTSGAGSSFGELALMYNSPRAATVVAQTDCTLWALDRLTFRKILLGSSFKKRLMYDDLLKNMEVLKSLSTYDRAKLADALDTKIYNAGDVIIREGDRGENFYLIEYGACDVTKEKEGLVTQLKDHDYFGEVALLNDLPRQATVTATKRTKVATLGKSGFQRLLGPAVEVLKLNDPTRKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQX6</accession>
    <name>Q6FQX6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0I02706g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQX6"/>
    <dbReference type="FunCoup" id="Q6FQX6">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQX6"/>
    <dbReference type="KEGG" id="cgr:2889022"/>
    <dbReference type="CGD" id="CAL0130328">
        <property type="gene designation" value="CAGL0I02706g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02706g"/>
    <dbReference type="eggNOG" id="ENOG502S7S3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FQX6"/>
    <dbReference type="OMA" id="FHPAEPQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000010">
        <property type="entry name" value="Large subunit ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="9">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0130328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="89" mass="9878" checksum="32142AC48D54B48D" modified="2004-07-19" version="1">MAYYKVTLVRSLIGTPEATRNIVKAIGLGKRGSVVYRKVSPSMAGSLAKIKELISVDVTKSRLTKQQQRELRKTNPGFTVEKQEDGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR18</accession>
    <name>Q6FR18_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0I01672g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR18"/>
    <dbReference type="FunCoup" id="Q6FR18">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR18"/>
    <dbReference type="KEGG" id="cgr:2889325"/>
    <dbReference type="CGD" id="CAL0130169">
        <property type="gene designation" value="CAGL0I01672g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01672g"/>
    <dbReference type="eggNOG" id="KOG0941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002173_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FR18"/>
    <dbReference type="OMA" id="MYYLFGA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="509"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0130169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="858" mass="99885" checksum="29A0A72660CCFFD0" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRA6</accession>
    <name>Q6FRA6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="7">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARO3</name>
        <name evidence="9 10" type="ordered locus">CAGL0H10142g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="7"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447238.1">
        <property type="nucleotide sequence ID" value="XM_447238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRA6"/>
    <dbReference type="SMR" id="Q6FRA6"/>
    <dbReference type="FunCoup" id="Q6FRA6">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRA6"/>
    <dbReference type="GeneID" id="2888486"/>
    <dbReference type="KEGG" id="cgr:2888486"/>
    <dbReference type="CGD" id="CAL0131756">
        <property type="gene designation" value="ARO3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10142g"/>
    <dbReference type="eggNOG" id="ENOG502QPSU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FRA6"/>
    <dbReference type="OMA" id="DINTGLR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="8">
        <location>
            <begin position="48"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0131756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="372" mass="41217" checksum="DB180D7FB80323BE" modified="2004-07-19" version="1">MFIKNDYRGDRTRLEDWRIKGYDPLTPPDLLQHEYPISEKGAANILKARDSVCDILNGKDDRMVIVIGPCSIHDPKAAYEYADKLAVIAEKLSDDLLIIMRAYLEKPRTTVGWKGLINDPDIDNSFQINKGLRISREMFTKLIEKLPIAGEMLDTISPQFLSDCFSLGAIGARTTESQLHRELASGLSFPIGFKNGTDGGLQVAIDAMRAASHEHYFLSVTKPGVTAIVGTEGNSDTFIILRGGKHGTNYDAENVKSTKEQLRKAKLIDEADSTRRIMIDCSHGNSNKDYRNQPKVAQEIYNQLSAGENGLCGVMIESNLVEGRQDVPPEGGREGLKYGCSITDACIGWDTTESVLELLAEGVRNRRKHLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRE4</accession>
    <name>Q6FRE4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Suppressor of disruption of TFIIS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SDT1</name>
        <name evidence="1 2" type="ordered locus">CAGL0H09218g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447200.1">
        <property type="nucleotide sequence ID" value="XM_447200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRE4"/>
    <dbReference type="FunCoup" id="Q6FRE4">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRE4"/>
    <dbReference type="GeneID" id="2888742"/>
    <dbReference type="KEGG" id="cgr:2888742"/>
    <dbReference type="CGD" id="CAL0131888">
        <property type="gene designation" value="SDT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09218g"/>
    <dbReference type="eggNOG" id="KOG3109">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059493_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRE4"/>
    <dbReference type="OMA" id="RHHTIDP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010237">
        <property type="entry name" value="Pyr-5-nucltdase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052791">
        <property type="entry name" value="SSM1_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01993">
        <property type="entry name" value="Pyr-5-nucltdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47438:SF1">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01132">
        <property type="entry name" value="C1.5.3:_5'-Nucleotidase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0131888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31803" checksum="079B384BAE19D768" modified="2004-07-19" version="1">MTIATDACNEHRLKVYREIKANEEHLNSLDHDGSKVTFVVDQEIPEPDENLRVFYFDIDNCLYPSSTRIHDLMQIAIVNYFEKQLGLDKVHAEELNRTYYKQYGLAIRGLTLHNGIDPMDYNTLVDDALPLQHILKPNLKLRETLIRLRECGKIDKLWLFTNAYKNHALRCVRLLGIADLFDGITYCDYNHAESLICKPDPAAFEKAKRESGLGDFKNAYYVDDSGSNIKTGLSLGIPKCAHLVEDKVLDVLGKTPEGSIVIKDITDLDKAFPELFQIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRL6</accession>
    <name>Q6FRL6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase MER3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAGL0H07601g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRL6"/>
    <dbReference type="FunCoup" id="Q6FRL6">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRL6"/>
    <dbReference type="KEGG" id="cgr:2888441"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FRL6"/>
    <dbReference type="OMA" id="VYGYQSH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="138"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="352"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="969"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1089" mass="124150" checksum="7BEC89A545A023BC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRP9</accession>
    <name>Q6FRP9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ARG81</name>
        <name evidence="8 9" type="ordered locus">CAGL0H06875g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447095.1">
        <property type="nucleotide sequence ID" value="XM_447095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRP9"/>
    <dbReference type="FunCoup" id="Q6FRP9">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRP9"/>
    <dbReference type="GeneID" id="2888437"/>
    <dbReference type="KEGG" id="cgr:2888437"/>
    <dbReference type="CGD" id="CAL0131844">
        <property type="gene designation" value="ARG81"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06875g"/>
    <dbReference type="eggNOG" id="ENOG502QQBG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009030_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FRP9"/>
    <dbReference type="OMA" id="ARQIMFE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0131844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="702" mass="81378" checksum="439A6677B382BAB0" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRT8</accession>
    <name>Q6FRT8_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H05973g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447056.1">
        <property type="nucleotide sequence ID" value="XM_447056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRT8"/>
    <dbReference type="FunCoup" id="Q6FRT8">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888901"/>
    <dbReference type="CGD" id="CAL0131552">
        <property type="gene designation" value="CAGL0H05973g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05973g"/>
    <dbReference type="eggNOG" id="ENOG502S12S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125620_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRT8"/>
    <dbReference type="OMA" id="EYMIERC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0131552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="165" mass="19512" checksum="35BD8C997B16026F" modified="2004-07-19" version="1">MQVVQLTEEFTRLNGVKDQAITKPVSLDDNTGEVVVRTSTGKSKIRKGQTEEEYRHQLKLYFEDERGPQVTEIGWLDEYIVDQDKIFSEESLFHDLSIKHNRQTVSGICHKLYYQRDYENCVSLAQKLRDLFEPYNTKNKIHRELEELDYMISKCNERLGSKEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRV1</accession>
    <name>Q6FRV1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0H05687g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRV1"/>
    <dbReference type="FunCoup" id="Q6FRV1">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRV1"/>
    <dbReference type="KEGG" id="cgr:2888906"/>
    <dbReference type="CGD" id="CAL0131852">
        <property type="gene designation" value="CAGL0H05687g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05687g"/>
    <dbReference type="eggNOG" id="ENOG502QT02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030057_6_2_1"/>
    <dbReference type="InParanoid" id="Q6FRV1"/>
    <dbReference type="OMA" id="AWHAVIM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0131852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="51989" checksum="8EC976CD352B5DB8" modified="2004-07-19" version="1">MRRLMKQLVRDFEPFMFVMVMASGISSNLLYDFAFPSHWMRVCSYIMFGIACAIFIVLQIYVFVHAYYSIKKDSFKVYFKRYYAGVTYGPFWGAYPMGLATIINYISFLANNEAAGTGNAKRLIVLAYALWWYDQLISLLTAWGVSFLIWQKYDFDKNDISPHVTPNQKSAAETLKSVLLLGVIPLVVASSSLGGFTMSPIFIKYFGRHIQLLNIFVCALSLFHALIFVFFIITIYIWSLYVNKIPPMGQVFSMFLILGPLGQGSYSFLLIGENVEKYTHLYYRPGHPYYNELLVEIIPWCFKIIFLLLVLALVSLGYFFTFLCFISILSYSKTKDATGPKVKRIYTFHKGWLGMTFPMGTMSLANKEIYVIYNNYVPVKTFRYIGAIYGGVCICWTIICLTLTLLQSIIKPVYFRYSKWKETEENTSTEKSLESSNDIQESCQDDFTRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS16</accession>
    <name>Q6FS16_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0H04213g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FS16">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS16"/>
    <dbReference type="KEGG" id="cgr:2888818"/>
    <dbReference type="CGD" id="CAL0131896">
        <property type="gene designation" value="CAGL0H04213g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04213g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003977_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FS16"/>
    <dbReference type="OMA" id="MAHQCLV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002058">
        <property type="entry name" value="YML081W-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1281"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="154"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="459"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="681"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="681"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0131896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1321" mass="147684" checksum="B765ED41559787E3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS48</accession>
    <name>RPB9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>DNA-directed RNA polymerase II subunit RPB9</fullName>
            <shortName>RNA polymerase II subunit B9</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>DNA-directed RNA polymerase II subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPB9</name>
        <name type="ordered locus">CAGL0H03509g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Involved in the regulation of transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446946.1">
        <property type="nucleotide sequence ID" value="XM_446946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS48"/>
    <dbReference type="SMR" id="Q6FS48"/>
    <dbReference type="FunCoup" id="Q6FS48">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS48"/>
    <dbReference type="EnsemblFungi" id="CAGL0H03509g-T">
        <property type="protein sequence ID" value="CAGL0H03509g-T-p1"/>
        <property type="gene ID" value="CAGL0H03509g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888695"/>
    <dbReference type="KEGG" id="cgr:2888695"/>
    <dbReference type="CGD" id="CAL0131596">
        <property type="gene designation" value="CAGL0H03509g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H03509g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03509g"/>
    <dbReference type="eggNOG" id="KOG2691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FS48"/>
    <dbReference type="OMA" id="DTSMVLF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000121471" description="DNA-directed RNA polymerase II subunit RPB9">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TFIIS-type" evidence="4">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P32529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="122" mass="14286" checksum="E70D9968949D2897" modified="2004-07-19" version="1">MTTFRFCRDCNNMLYPREDKENNRLLFECRTCSYIEEAGSPLVYRHELITNIGETAGVVQDIGSDPTLPRSDRECPKCHSRENVFFQSQQRRKDTSMVLFFVCLACSHIFTSDQKNKRTQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS97</accession>
    <name>Q6FS97_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0H02343g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS97"/>
    <dbReference type="FunCoup" id="Q6FS97">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS97"/>
    <dbReference type="KEGG" id="cgr:2888655"/>
    <dbReference type="CGD" id="CAL0130442">
        <property type="gene designation" value="CAGL0H02343g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02343g"/>
    <dbReference type="eggNOG" id="ENOG502RZ9X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106811_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS97"/>
    <dbReference type="OMA" id="THITNNH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016479">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000219">
        <property type="term" value="P:positive regulation of invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286:SF6">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30L-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="8">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0130442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="178" mass="20174" checksum="EB3A3CE713D146CA" modified="2004-07-19" version="1">MARANNSNSESETKTRNNNQGNAGSSNASNTTSAGSNSQSSRSNAKQRLTAAQQQYIRDLINEHITNNDPTLEEKPHPLDFEQYSEEFIRAYKDHFGLNVPDQMTLQGYLLGSELGKRTISYKRNVSSVPGHRITKTEAASKIKKHFNSLSIKETECIPNFIYKVRNQKKKFKMEFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSU3</accession>
    <name>Q6FSU3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0G07799g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSU3"/>
    <dbReference type="FunCoup" id="Q6FSU3">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSU3"/>
    <dbReference type="MEROPS" id="S54.007"/>
    <dbReference type="KEGG" id="cgr:2888378"/>
    <dbReference type="CGD" id="CAL0129855">
        <property type="gene designation" value="CAGL0G07799g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07799g"/>
    <dbReference type="eggNOG" id="KOG2980">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034022_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FSU3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010821">
        <property type="term" value="P:regulation of mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000012">
        <property type="entry name" value="Rhomboid family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="8">
        <location>
            <begin position="178"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0129855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="341" mass="38247" checksum="5BE8555170BE91AB" modified="2004-07-19" version="1">MFLSVGLRSNPVKLSFFRFSSIKCSKPLGSALTIRSLSNKCISSSPIHSQLSNIISKRNFSNGKFSLRGSWESIFKDNGSDRYTRLNRFQQFQRNSGNSNSLGVITAFGVGAMAVIYFISPYLFNIVPPFTYFKHNPKDLVYAILGTNLLVFGMWRIPQCWRFLQKYMLLQKDHMASKWAIVGSAFSHQEFWHLGMNMLALWSFGTSLASILGTANFFSLYMNSAIAGSLFSLWYPRIAKLMMIGPSLGASGALFGVFGSFAYLFPQAKILLFVFPIPGGAWVAFLGSVAWNLAGCVLRWGSFDYAAHLGGSLMGIAYGWYISTLMKKRRERRIKSVSKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT77</accession>
    <name>Q6FT77_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G04763g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT77"/>
    <dbReference type="FunCoup" id="Q6FT77">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT77"/>
    <dbReference type="KEGG" id="cgr:2888302"/>
    <dbReference type="CGD" id="CAL0130067">
        <property type="gene designation" value="CAGL0G04763g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04763g"/>
    <dbReference type="eggNOG" id="KOG3589">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_676139_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT77"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="33"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0130067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="407" mass="46355" checksum="F4C2EC46BDFDA920" modified="2004-07-19" version="1">MSQFPTLYDILLQPGNRNVENRKDDGPFNIETFHRFLLKAHCEENLEFFQYCNTYICTKTRKEAISLDMANSKSETDLATTESHQHRLLKMWNNRIYLKYIALNSPRECNFPQEIREVFEKCYEEQQLPSDESVLIAMQHILQLLMDAYRQFIKFVNNSNDPLEELISEKSEAIITNFGEGDSTASTISKENEEDELKKTSALNWFDSNIPSTLESTTSHWGISSGHFPESNYLMTPKVNLSANDILLSSTTKLAPSVSPLISREISDIMNKNKSSVKRASTDQSLQTNTDPVSPKRRSLETDKRKSVSPILISPNNKSHSNKYSKSNGSSHVNRSIKASTSPLSHRVVLPNDRKIQRPISPPMTNLPHEHHSSTIVGKGKQLFNKLSMVGRKKNYSSHIPQQHSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTA6</accession>
    <name>Q6FTA6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G04037g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446538.1">
        <property type="nucleotide sequence ID" value="XM_446538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTA6"/>
    <dbReference type="FunCoup" id="Q6FTA6">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTA6"/>
    <dbReference type="KEGG" id="cgr:2888315"/>
    <dbReference type="CGD" id="CAL0130354">
        <property type="gene designation" value="CAGL0G04037g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04037g"/>
    <dbReference type="eggNOG" id="KOG2208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020231_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTA6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="K Homology" evidence="1">
        <location>
            <begin position="153"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="1">
        <location>
            <begin position="450"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="778" mass="89591" checksum="D6A857893D1C19C1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTA9</accession>
    <name>Q6FTA9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0G03971g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTA9"/>
    <dbReference type="FunCoup" id="Q6FTA9">
        <property type="interactions" value="398"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTA9"/>
    <dbReference type="MEROPS" id="M24.A10"/>
    <dbReference type="KEGG" id="cgr:2888252"/>
    <dbReference type="CGD" id="CAL0130632">
        <property type="gene designation" value="CAGL0G03971g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03971g"/>
    <dbReference type="eggNOG" id="KOG2413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011781_2_6_1"/>
    <dbReference type="InParanoid" id="Q6FTA9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071281">
        <property type="term" value="P:cellular response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.350.10:FF:000015">
        <property type="entry name" value="Xaa-Pro aminopeptidase app-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="14">
        <location>
            <begin position="119"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="13">
        <location>
            <begin position="468"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="15">
        <location>
            <begin position="693"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0130632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG59462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="755" mass="85099" checksum="AE8B5D70A158891B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTG6</accession>
    <name>FYV10_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein FYV10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FYV10</name>
        <name type="ordered locus">CAGL0G02651g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FYV10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446478.1">
        <property type="nucleotide sequence ID" value="XM_446478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTG6"/>
    <dbReference type="SMR" id="Q6FTG6"/>
    <dbReference type="FunCoup" id="Q6FTG6">
        <property type="interactions" value="964"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTG6"/>
    <dbReference type="EnsemblFungi" id="CAGL0G02651g-T">
        <property type="protein sequence ID" value="CAGL0G02651g-T-p1"/>
        <property type="gene ID" value="CAGL0G02651g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888366"/>
    <dbReference type="KEGG" id="cgr:2888366"/>
    <dbReference type="CGD" id="CAL0130701">
        <property type="gene designation" value="CAGL0G02651g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02651g"/>
    <dbReference type="eggNOG" id="KOG0396">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027445_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FTG6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000292455" description="Protein FYV10">
        <location>
            <begin position="1"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="175"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="3">
        <location>
            <begin position="406"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="488" mass="56784" checksum="A565205A01AB20B3" modified="2004-07-19" version="1">MAETTSLINEPDVDFHLKLNQHSFNIPYEQLQRNSRYLNRLIEKEIDELNSHYERLNIALGSGNIEGDKKALQELKDIIRSVEIFEKRLQKRVNEEVPILKRLEVRINFFKELENAKQQVADITPLMEWYLKFTNILIGDYLTRHTTSNSSPELGLPGVTFLEQEGIQDLLDTDILLTGNRISTALVDNHDLRPLLDWINDSKSYLKKNGSRLEFEARFQQYIELLKASEYEEAIKCFQDYLLKFVNTNFNELTHASGLLLSINYCKEIMKAKASERSAILTKDDGNPLENEIRAYKYFFHKKPKIVEQQHVKPVDLSYMNLSQNTDFEKYMLLLDDKRWGLLNELFLKDYYSLYGISQNDPLLIYLSLGISTLKTRECLHHRRVAKSSSPLVDKKVEEEVLQNSCPVCDKTFAPIAESLPFAHHTQSQLFDDPIMLPNGNIYEAKRLKRLAKYLVDIKAIELGETEVIDPIDKQIYNEADFITMYPT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTI0</accession>
    <name>TVP38_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TVP38</name>
        <name type="ordered locus">CAGL0G02343g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Golgi apparatus membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446464.1">
        <property type="nucleotide sequence ID" value="XM_446464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTI0"/>
    <dbReference type="SMR" id="Q6FTI0"/>
    <dbReference type="FunCoup" id="Q6FTI0">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTI0"/>
    <dbReference type="EnsemblFungi" id="CAGL0G02343g-T">
        <property type="protein sequence ID" value="CAGL0G02343g-T-p1"/>
        <property type="gene ID" value="CAGL0G02343g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888032"/>
    <dbReference type="KEGG" id="cgr:2888032"/>
    <dbReference type="CGD" id="CAL0137539">
        <property type="gene designation" value="CAGL0G02343g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02343g"/>
    <dbReference type="eggNOG" id="KOG3140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041954_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FTI0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000343066" description="Golgi apparatus membrane protein TVP38">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="170"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="VTT domain" evidence="1">
        <location>
            <begin position="149"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P36164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="323" mass="36739" checksum="C7E5C308D858B9C5" modified="2004-07-19" version="1">MPTDNADLGQEDIDVFDNGRESFDRLNKPVLDGIGIEGNDDDDDDYLTLYNMTPRERLMYTFRRSMYKALDHFNSLPKWQRLLIILFGALVIVLGILMLIFHNKILDKVLETSKDLNERSSTNFILLVLLFFVGFPPMIGYSFLSTSTGLIYGVSFHGWFVLALGSVTGSVASFYVFKNLLHSRAEKLVHMNKRFEAFASILQEDNSYLMLALLRLCPFPYSLTNGAIAGIYGISVKNFTIANIITTPKLLIYLFIGARIKNMAEDHSTSSRIFDLVSILITLIIFTLTAWLLYFKTKQRYAQLKNQAVAQNSSANREVDFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTQ4</accession>
    <name>Q6FTQ4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating</fullName>
            <ecNumber evidence="13">1.1.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">C-3 Sterol dehydrogenase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">C-4 decarboxylase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Sterol-4-alpha-carboxylate 3-dehydrogenase erg26, decarboxylating</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ERG26</name>
        <name evidence="21 22" type="ordered locus">CAGL0G00594g</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>4beta-methylzymosterol-4alpha-carboxylate + NADP(+) = 3-dehydro-4-methylzymosterol + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:33447"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:50593"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:64925"/>
            <dbReference type="EC" id="1.1.1.170"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33448"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.170" evidence="13"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446390.1">
        <property type="nucleotide sequence ID" value="XM_446390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTQ4"/>
    <dbReference type="FunCoup" id="Q6FTQ4">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTQ4"/>
    <dbReference type="GeneID" id="2888099"/>
    <dbReference type="KEGG" id="cgr:2888099"/>
    <dbReference type="CGD" id="CAL0130719">
        <property type="gene designation" value="ERG26"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00594g"/>
    <dbReference type="eggNOG" id="KOG1430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_8_1"/>
    <dbReference type="InParanoid" id="Q6FTQ4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102175">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09813">
        <property type="entry name" value="3b-HSD-NSDHL-like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000346">
        <property type="entry name" value="C-3 sterol dehydrogenase/C-4 decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="20">
        <location>
            <begin position="9"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0130719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG59317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="349" mass="38420" checksum="BC40B32BA6FCDE60" modified="2004-07-19" version="1">MSEIKSVLLIGGAGFLGLHLIQQFYDVSPRPDIHIFDIRPLPEKISKQFTFDVNDIKFHKGDLTSSEDIKKAILASKCNVVVHSASPVHGGAAEVYHKVNVTGTRNIIDTSKKCGVKALVYTSSAGVIFNGQDIHNADETWPIPEVPMDAYNETKAIAEDMVLKANDPDNDFLTIALRPAGIFGPGDRQLVPGLRTVAKLGQSKFQIGDNNNLFDWTYAGNVADSHVLAAKKLLDPSTAAKVSGETFFITNDTPAYFWALARTVWKADGHVDKRVIVLKRPLAIVAGYLSEWVSKLVGKEPGLTPFRVKIVCAYRYHNIAKAKELLGYYPKVDIEEGIKKTLAWMDEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU35</accession>
    <name>Q6FU35_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0F06699g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446259.1">
        <property type="nucleotide sequence ID" value="XM_446259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU35"/>
    <dbReference type="KEGG" id="cgr:2887654"/>
    <dbReference type="CGD" id="CAL0130976">
        <property type="gene designation" value="CAGL0F06699g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06699g"/>
    <dbReference type="HOGENOM" id="CLU_1408566_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU35"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0130976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="193" mass="22638" checksum="1E5AA5596ADDCC29" modified="2004-07-19" version="1">MGRINHKPLINGKRHEFKRKLNDKVEDFVRKSQKTITTRMNKVEKKINDVGESENSLLSSVSLTLKTISKSSPIRNGPNPLSYCMSCPTKCREHRQPFKTPYRAHQEPKVQYVRSTTQRSRFTAKKFTKSYRSDPLPRLKLRPYNHPWDSPLSKRDKSIQLNPYCSERARPITFDIKPPKFTRMPYGKATKFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU78</accession>
    <name>RUVB1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>RuvB-like helicase 1</fullName>
            <ecNumber>3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RVB1</name>
        <name type="ordered locus">CAGL0F05643g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446216.1">
        <property type="nucleotide sequence ID" value="XM_446216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU78"/>
    <dbReference type="SMR" id="Q6FU78"/>
    <dbReference type="FunCoup" id="Q6FU78">
        <property type="interactions" value="1737"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU78"/>
    <dbReference type="EnsemblFungi" id="CAGL0F05643g-T">
        <property type="protein sequence ID" value="CAGL0F05643g-T-p1"/>
        <property type="gene ID" value="CAGL0F05643g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887725"/>
    <dbReference type="KEGG" id="cgr:2887725"/>
    <dbReference type="CGD" id="CAL0129272">
        <property type="gene designation" value="CAGL0F05643g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_F05643g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05643g"/>
    <dbReference type="eggNOG" id="KOG1942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FU78"/>
    <dbReference type="OMA" id="RTLPYNK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000165651" description="RuvB-like helicase 1">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="73"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="457" mass="49849" checksum="02EDEC8023A5A3AB" modified="2004-07-19" version="1">MVQITEVNESKAGTANRTAAHTHIKGLGLDDTGAARQVEGGFVGQVEAREACGVIVDLIKAKKMSGRAILLAGGPSTGKTALALAISQELGPKVPFCPLVGSELYSVEVKKTETLMENFRRAIGLRIKETKEVYEGEVTELTPEDAENPLGGYGKTISHVIVGLKSAKGTKTLRLDPTIYDSIQKEKVSIGDVIYIEANTGAVKRVGRSDAYATEFDLEAEEYVPLPKGEVHKKKEIVQDVTLHDLDIANARPQGGQDVISMMGQLMKPKKTEITEKLRFEVNKVVAKYVDQGVAELIPGVLFIDEANMLDIEIFTYLNKALESDIAPIVVLASNRGMTTVRGTEDVISPHGIPADLIDRLLIVRTLPYNKDEIRLIIERRSAVENLALEDGALDILADMATHTSLRYALQLLSPAGILSSTAGRQKITIDDINEAKMLFIDAKRSTKILENSDRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU79</accession>
    <name>Q6FU79_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0F05621g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU79"/>
    <dbReference type="FunCoup" id="Q6FU79">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU79"/>
    <dbReference type="KEGG" id="cgr:2887775"/>
    <dbReference type="CGD" id="CAL0129434">
        <property type="gene designation" value="CAGL0F05621g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05621g"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021544_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FU79"/>
    <dbReference type="OMA" id="QLHGSIN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099115">
        <property type="term" value="C:chromosome, subtelomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005721">
        <property type="term" value="C:pericentric heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140765">
        <property type="term" value="F:histone H3K56 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140861">
        <property type="term" value="P:DNA repair-dependent chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009299">
        <property type="term" value="P:mRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046459">
        <property type="term" value="P:short-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="7">
        <location>
            <begin position="69"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="364" mass="40458" checksum="0BD37BAE4E7788B2" modified="2004-07-19" version="1">MVAISKDTKMLLTPPSSTKKPVVESNVGKVTPRRLFARGKSGRKPRLKSRPAPFTIFSIDDYLSGITSEKHSSDGAAEFLRYAFQYSKKIVAVVGAGISVAAGIPDFRSSEGLFETLKGDSVASGKELFDFNRVYSSDEMSKKFHSMIVDLHSLSQKSEPTKFHLLLDHLASQQRLVRLYTQNIDGLDTRLENLKTTVPLDKPIPTTIQLHGSVDYMECNLCAKIDCFNPEAFENEGEIIPLCPQCKEFDEVRKVAGIRSKGLGKLRPRVVLYNEVHPEGDLIGQVSNKDLKQKIDFLLIAGTSLKIPGVLQMCKKFIEKVVKNKGIVIYFNKEMPTQSLLKSLGHIDLIVLGDCQNISDLLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUN8</accession>
    <name>Q6FUN8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fcf2 pre-rRNA processing C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0F01925g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUN8"/>
    <dbReference type="FunCoup" id="Q6FUN8">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUN8"/>
    <dbReference type="KEGG" id="cgr:2887846"/>
    <dbReference type="CGD" id="CAL0129990">
        <property type="gene designation" value="CAGL0F01925g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01925g"/>
    <dbReference type="eggNOG" id="KOG3100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075129_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FUN8"/>
    <dbReference type="OMA" id="DDTNKYF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="98"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0129990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG58980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="218" mass="26061" checksum="BDE00CD4E5FFC4BC" modified="2004-07-19" version="1">MDEIDALFEQLKEVSSKENGTSKTKVDELNEDKVIFDDEDSKEKEFLRIEKELRRLPKLETGFDSLAQTKKGEVKKHEMGLTEEERRKREKMIKDAQKKKTSEEWFTLPKPDDKAKREIQRDLLLIKHRAALDPKRHYKKDRWKVPDRFSVGTIVEDKTEFYSSRLTNKQRKSTMLETLMTDDTTNKYFKRKYSQIQEQKMSGKKGHYKKMKAARHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUQ7</accession>
    <name>Q6FUQ7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLG1</name>
        <name evidence="9 10" type="ordered locus">CAGL0F01507g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446037.1">
        <property type="nucleotide sequence ID" value="XM_446037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUQ7"/>
    <dbReference type="FunCoup" id="Q6FUQ7">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUQ7"/>
    <dbReference type="GeneID" id="2887711"/>
    <dbReference type="KEGG" id="cgr:2887711"/>
    <dbReference type="CGD" id="CAL0131148">
        <property type="gene designation" value="SLG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01507g"/>
    <dbReference type="eggNOG" id="KOG4157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024893_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FUQ7"/>
    <dbReference type="OMA" id="HINMKRE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273531" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="19"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="375"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="113"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0131148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="423" mass="44983" checksum="17C6E538742DDAFE" modified="2004-07-19" version="1">MMMLLILAVLAAVTRAQSDYTYMNCYVSLPSDFSSDNTYAYQTSSYCYSRCQQKGAAYFALFNHNQCFCGNTSPSSQTSSSCNTYCFGYAQEMCGGNSAYSVFQIGNGNPSQSSSNTNSNSNTNTNTNTNTNSNSNSNSNSNTNTNTNTNTNTNSNTNTNTNTNSNSNSNTNTRPTSTLSSSRLVALGTGLSIEPSSSVEPTTQATTIASSTVNNGVTSIVYSTSLKTISGSVIYRTSTIVQSAAPTDAGNSTSSDDDSSGKNNSGKHKKKANVGAIVGGVVGGVVGACVVAVAALLILRHINLKREQERMEKEYQEAIKPVEYPENNELFPSPYSSNRDPSSGSFDEELRNKAMYPPATGTDPYENNDLMAMPDRKPSTNNHLAVANPFDDSRRISNGSLVPGSPPLGNNNVLTVVNPDETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUS1</accession>
    <name>Q6FUS1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0F01133g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUS1"/>
    <dbReference type="FunCoup" id="Q6FUS1">
        <property type="interactions" value="751"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUS1"/>
    <dbReference type="KEGG" id="cgr:2887963"/>
    <dbReference type="CGD" id="CAL0129181">
        <property type="gene designation" value="CAGL0F01133g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01133g"/>
    <dbReference type="eggNOG" id="KOG1149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_1"/>
    <dbReference type="InParanoid" id="Q6FUS1"/>
    <dbReference type="OMA" id="HGATNVM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="An anticodon-binding domain of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="12">
        <location>
            <begin position="47"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class I anticodon-binding" evidence="13">
        <location>
            <begin position="407"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0129181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="532" mass="61024" checksum="79FDE63E441535CC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV14</accession>
    <name>Q6FV14_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0E05566g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV14"/>
    <dbReference type="FunCoup" id="Q6FV14">
        <property type="interactions" value="1223"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV14"/>
    <dbReference type="KEGG" id="cgr:2887552"/>
    <dbReference type="CGD" id="CAL0128752">
        <property type="gene designation" value="CAGL0E05566g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05566g"/>
    <dbReference type="eggNOG" id="KOG2588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067895_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FV14"/>
    <dbReference type="OMA" id="YRININM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11395">
        <property type="entry name" value="bHLHzip_SREBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF3">
        <property type="entry name" value="SERINE-RICH PROTEIN TYE7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="124"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="242" mass="27461" checksum="6833288341799FFA" modified="2004-07-19" version="1">MATKIEQHDLDNWVNTTNEKYPFSTSESSTSLATSGSPWFEPLENIISSNSSSSVTSPSDSNNFLLTENGYDNIFAFNENDKDFQLKTEDDDDQLVSFEAAMESMPATCKKQKKKAPRKRLTQNQKEAHNKIEKRYRININSKLAKLQQIIPWVASEQSTFEVADGNKRATSKTEEGDDAFANFPSTTPKLNKSMILEKAVDYILYLQNNEKLFEMEVHRLKSELGAVKKENQELKQLATGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV44</accession>
    <name>Q6FV44_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAGL0E04884g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FV44">
        <property type="interactions" value="943"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV44"/>
    <dbReference type="KEGG" id="cgr:2887341"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006588_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FV44"/>
    <dbReference type="OMA" id="KIRCTLM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF28">
        <property type="entry name" value="REGULATORY PROTEIN ADR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="807"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="880"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="359"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1358"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1358"/>
            <end position="1367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1489" mass="169776" checksum="0ECF183B78F7E41F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV80</accession>
    <name>Q6FV80_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0E04070g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV80"/>
    <dbReference type="FunCoup" id="Q6FV80">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV80"/>
    <dbReference type="KEGG" id="cgr:2887321"/>
    <dbReference type="CGD" id="CAL0129044">
        <property type="gene designation" value="CAGL0E04070g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04070g"/>
    <dbReference type="eggNOG" id="KOG1337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030667_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FV80"/>
    <dbReference type="OMA" id="WGIRQFI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017119">
        <property type="entry name" value="Efm1/Rkm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF147">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037136">
        <property type="entry name" value="Ribosomal_Lys-mtfrase-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="585" mass="67944" checksum="0FB7F3AEA63DE29C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVN2</accession>
    <name>Q6FVN2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional repressor Tup1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TUP11</name>
        <name evidence="10 11" type="ordered locus">CAGL0E00561g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVN2"/>
    <dbReference type="FunCoup" id="Q6FVN2">
        <property type="interactions" value="2200"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVN2"/>
    <dbReference type="KEGG" id="cgr:2887491"/>
    <dbReference type="CGD" id="CAL0128588">
        <property type="gene designation" value="TUP11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00561g"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_23_1"/>
    <dbReference type="InParanoid" id="Q6FVN2"/>
    <dbReference type="OMA" id="CNLMWSR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036033">
        <property type="term" value="F:mediator complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000879">
        <property type="term" value="P:negative regulation of dipeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042304">
        <property type="term" value="P:regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000111">
        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="558"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="593"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="634"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="684"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="738"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="67"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0128588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="836" mass="91613" checksum="3D7DB965DA132C20" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVW9</accession>
    <name>Q6FVW9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0D04928g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVW9"/>
    <dbReference type="STRING" id="284593.Q6FVW9"/>
    <dbReference type="KEGG" id="cgr:2886996"/>
    <dbReference type="CGD" id="CAL0128423">
        <property type="gene designation" value="CAGL0D04928g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D04928g"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_1"/>
    <dbReference type="InParanoid" id="Q6FVW9"/>
    <dbReference type="OMA" id="RANYNAY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="21"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0128423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="452" mass="49892" checksum="4C9378E73F8550E9" modified="2004-07-19" version="1">MLARRGVQYVWDSGIAVSSTAFLVVASALVFFMVPGIGFLYSGLARRKSALSLLWVTLMASLVGMLQWYFWGYSLALSRTATNNKFIGNLDSFGFRNVYGLNAVWTENLEVAYASFQMMFLCVTLSLVAGSTAGRGRFFPHMVYLFLFATLVYCPIVYWIWAPGGWANKWGVLDWAGGGPVEIVSAISGFVYSYFLGCRNERFLVNFRAHNVSYVTLGTTVLWFGWLLFNAASALSPNLRSVYAFLNTNISAVTGGMTWCILDYRLEKKWSTVGLCSGIICGLVAATPSSGCITLYGSLIQGIVAGICCNFATKIKHFFQVDDAMDLLAEHGVAGMIGLLFNGFFAADWVIGMDGHTTHGGGWITQNYKQMYKQIAYIGAVTGYCAAVSALLCFIIDKIPGLQLRVSADGEEKGTDDDQIGEFAYDFVEIRREFDIWGKEEDEDENEQSTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW97</accession>
    <name>Q6FW97_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0D01914g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW97"/>
    <dbReference type="FunCoup" id="Q6FW97">
        <property type="interactions" value="828"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW97"/>
    <dbReference type="KEGG" id="cgr:2887099"/>
    <dbReference type="CGD" id="CAL0128525">
        <property type="gene designation" value="CAGL0D01914g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01914g"/>
    <dbReference type="eggNOG" id="KOG0812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044998_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FW97"/>
    <dbReference type="OMA" id="EHNHNVV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090083">
        <property type="term" value="P:regulation of inclusion body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="244"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0128525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="335" mass="37868" checksum="4694EC838FD219F8" modified="2004-07-19" version="1">MNIKNRTFEFQQSVATYKKRVKKNDATSNGKPQAGVSEFQKKASAIAREISSSAQLLSKLALLAKRKPMLNDNPVEIAELSFLIKRKIYAIEQSLIDLSKLQKVQRNGGNSSAGSTTDVTTQHSKNVVNLLNTKMRNISGGFKDVLEERQRMEMANRDRWEKINSTSNSTSRAMSNTQDSENKNLNDNAMVNEVATYNHSNPFMSSSLIDEESHANANKGSELALPQSDSQMLLMMEEGQMANNVYLQERNRAVETIESTIQEVGNLFQQLASMVQEQGEVIQRIDANVDEVDLNITGAQRELLKYFDRVKSNRWLVAKIFFIVFVFFLVWVLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWA8</accession>
    <name>Q6FWA8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor BRR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0D01628g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWA8"/>
    <dbReference type="FunCoup" id="Q6FWA8">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWA8"/>
    <dbReference type="KEGG" id="cgr:2887070"/>
    <dbReference type="CGD" id="CAL0128541">
        <property type="gene designation" value="CAGL0D01628g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01628g"/>
    <dbReference type="eggNOG" id="ENOG502S02X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_748374_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWA8"/>
    <dbReference type="OMA" id="NEPSHSI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023251">
        <property type="entry name" value="Brr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02039">
        <property type="entry name" value="SPLICEFRBRR1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="41811" checksum="405EA25ADB0D1B5C" modified="2004-07-19" version="1">MAGRNRNSKDQNKEALSSAIDPVFGQAKAFNINDPEVNPLVKSYLSEVRNEALHTNAISHQIGQVSKNTFDANIYDDEDDSTSIPSDTKVKSDQITEYLYSIENWYKWFENISDIIWHGCYVFEGYDDESISHLTQLLRFYLQKKIDENRASSFDRHLVNIFRDQLKCSDPDPVNGTLEIDEDWAENLLKTMRNSKIKDLNTVKYCIRTDYKRAPHGLKPWAKYVTSNQPTHTAFINMIDSSNLWTLVMYMTQIWLKEIYTFGKNLERKKMLSQWLLYILLHIPTRLTAEQMSNIRSLAKQAREILNRRVNSNIFGTTNIVIPDELHEHNCPPCPPNLDIASLILAVVTRKYGQHDILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWC3</accession>
    <name>Q6FWC3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TKL1</name>
        <name evidence="17 18" type="ordered locus">CAGL0D01298g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445471.1">
        <property type="nucleotide sequence ID" value="XM_445471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWC3"/>
    <dbReference type="SMR" id="Q6FWC3"/>
    <dbReference type="FunCoup" id="Q6FWC3">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWC3"/>
    <dbReference type="GeneID" id="2887198"/>
    <dbReference type="KEGG" id="cgr:2887198"/>
    <dbReference type="CGD" id="CAL0128375">
        <property type="gene designation" value="TKL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01298g"/>
    <dbReference type="eggNOG" id="KOG0523">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWC3"/>
    <dbReference type="OMA" id="ADYMRGS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="355"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0128375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG58382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="679" mass="73750" checksum="BA8A6757FD648AD7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWJ4</accession>
    <name>Q6FWJ4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0C05203g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <location evidence="8">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWJ4"/>
    <dbReference type="FunCoup" id="Q6FWJ4">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWJ4"/>
    <dbReference type="KEGG" id="cgr:2886781"/>
    <dbReference type="CGD" id="CAL0127172">
        <property type="gene designation" value="CAGL0C05203g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05203g"/>
    <dbReference type="eggNOG" id="KOG0938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_5_2_1"/>
    <dbReference type="InParanoid" id="Q6FWJ4"/>
    <dbReference type="OMA" id="VWKIPRI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="202"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0127172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="475" mass="53861" checksum="453BD3CEC9DA7AFF" modified="2004-07-19" version="1">MISAVLVFSSRGELIVSKFFKNNLKRSISDIFRIQVINNLDVRSPILTLGSTTFQHIRSNVHGDDLWLVSVTRSNINCGAVWEFLYKFDHMLELYGLNNEEFLKEEFMVCYELLDVMLGENGTPMDTDPATVIKKMSVKPSKETIENFAISVQNKNSTLPKIPKFLRRTSSFLNQESSNNSSGAFNMAGELPWRPKGISHKKNEIFLYVNEKISILVSKEGSILKSYVDGTIDLVTHLSGTPVCQFGLNDSLSVKNDDYGDSFDYIKNKKAIPKAAAGSVLLEDCKFHQCVSLEKFDKDRIIKFVPPDGSMELMKYHVRSNINLPFKVSPIVTYSSSGTAVEYRITLKSLFPSKLTAKNVTMKIPVPPETLDCKIDVSNGSCKFAPEEKAMLWTFNKYNGLTENTLSAVTITSKDAPRLNIQQWQKPPISLDFEIMMFSNSGLVVRYFTIKESERYKTVKWIRYVSKSGSYEIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWK9</accession>
    <name>Q6FWK9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAGL0C04873g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWK9"/>
    <dbReference type="FunCoup" id="Q6FWK9">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886832"/>
    <dbReference type="eggNOG" id="ENOG502RCP9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065389_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FWK9"/>
    <dbReference type="OMA" id="WGHLKGA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052999">
        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180">
        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="213"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="291" mass="32927" checksum="CD7CD324E4DC0A49" modified="2004-07-19" version="1">MKSVLNAQRLIQLSQFHPKLQNIWYLVAAVTFSVCNHPQELPKLYHYALALSNENADIHRITLAGKCNDMVDNCMRRPDLRESIINEGFQQPSILHSTITRKFRESILKSGPLAGLPKAINGLHSLKEYTPLSLLPSVSREIDPWHASVNNCRPYMSNEESKTGTGRVEEDFEDREVAMQRGLKHWNSIYNKVSQRIINNMNSSYPDLWYYTLVHVYGPLLSNDEVLSAQETSFIVIAALVPQDVNPQLKGHLRGALNIGCDREAIEAARSLAILVAKWCGVTWHADIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWR3</accession>
    <name>Q6FWR3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COX3 mRNA-specific translational activator PET494</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0C03553g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWR3"/>
    <dbReference type="FunCoup" id="Q6FWR3">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWR3"/>
    <dbReference type="KEGG" id="cgr:2886730"/>
    <dbReference type="CGD" id="CAL0127246">
        <property type="gene designation" value="CAGL0C03553g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03553g"/>
    <dbReference type="eggNOG" id="ENOG502S01Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042193_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWR3"/>
    <dbReference type="OMA" id="ILINDSM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="52256" checksum="B82F6CD28920694A" modified="2004-07-19" version="1">MKKYNICKFWTRFYSSPQFFNARVRAGGLLNESQPRGNLWSFFRTPGNITFVTTNIVTFVGIVTYDTFVSANEERIFEERLAVARLSVEKSGREGIILEDTVPMLPQRRPSGEEYMDKQAQDKELAKLDDQIEILRKELEERKKLDLQLRQMEANIKEEAVDSPLQTYTASEVTLRDKGKVKNLVSQRVKMSLFQMVYSFYSYKSALLSQNKDIEPEMDEFYHFWSEKYGQVNCDMEKVKEFKLPDWQKYPNLMKKFCYQLYDREIRRLSDFEHIYYSADSRELKQLLRLWLYDNWYLLKPTLRSDEVLQRRDGRFFKDLVRDSRGDHALFSKYMSIVTQDNPRSVLFFQQDKFNLPSISLATYVSLLETSERTHHNLTTVRLIQLLKTNCYLDKNQHVRILLAPPDGLQTPQMAKSRRICYRYLSKDRRLTALLDTISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX12</accession>
    <name>Q6FX12_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0C01331g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG58138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="gene designation" value="CAGL0C01331g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C01331g"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome C"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0127520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="374" mass="41937" checksum="AD22DDD42F7929A1" modified="2004-07-19" version="1">MSFSFGFTSESFSDDELNDDIVNVQQSQSDAQNSLAINPLDDPRLVSPEVIQPEVLDFSSVVRSLKDVRLTFETLSLFDGQIQLYRRELFDVKHQLMSESNVEQTTTNENGDPILEILLGDTAEDVRKNVYEGGLKSWECSIDIIELLNNHGKDFSTEQIFDMGCGTALPSTFVFGKYLQSKLDSGLNLILADYNKSVLELVTLPNLIITWAKTVLTEDEWISLQRSSDENVAIVGDELLLTTILLQAFMDDLSARKIKINLISGSWGRVFSNLVRHHVTPTRPLLVFSSETIYQPENLPVVAETLLDLYQGDNRTSTKALVAAKDIYFGVGGSVIEFESYLRKRLTESNLPITFDTFKVNSNLKRSIVALQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX61</accession>
    <name>Q6FX61_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Laminarase-resistance protein LRE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0B00528g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX61"/>
    <dbReference type="FunCoup" id="Q6FX61">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886613"/>
    <dbReference type="CGD" id="CAL0127086">
        <property type="gene designation" value="CAGL0B00528g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B00528g"/>
    <dbReference type="eggNOG" id="ENOG502RXFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026385_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX61"/>
    <dbReference type="OMA" id="NINAQSM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG57893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="74318" checksum="C3A34D08F1FA73F7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXJ1</accession>
    <name>Q6FXJ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0B03509g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXJ1"/>
    <dbReference type="FunCoup" id="Q6FXJ1">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXJ1"/>
    <dbReference type="KEGG" id="cgr:2886619"/>
    <dbReference type="CGD" id="CAL0127922">
        <property type="gene designation" value="CAGL0B03509g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03509g"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006421_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FXJ1"/>
    <dbReference type="OMA" id="FKARDTV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007231">
        <property type="term" value="P:osmosensory signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040020">
        <property type="term" value="P:regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000731">
        <property type="entry name" value="Serine/threonine-protein kinase RCK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="150"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="17"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0127922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG58024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="597" mass="68004" checksum="D3A23DBFF3904E64" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXR6</accession>
    <name>Q6FXR6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0A04719g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXR6"/>
    <dbReference type="FunCoup" id="Q6FXR6">
        <property type="interactions" value="1264"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXR6"/>
    <dbReference type="MEROPS" id="T01.A13"/>
    <dbReference type="KEGG" id="cgr:2886405"/>
    <dbReference type="CGD" id="CAL0126857">
        <property type="gene designation" value="CAGL0A04719g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04719g"/>
    <dbReference type="eggNOG" id="KOG0185">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072435_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FXR6"/>
    <dbReference type="OMA" id="QPIMRRY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0126857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG57866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="265" mass="29797" checksum="93A2F7DFF4260565" modified="2004-07-19" version="1">MNHDPFSWGRPSEQTYGQYDHSIAQASIPKMNTQDPIVTGTSVISMKYNNGVVIAADNLAAYGSLLRFNGVERLIPVGENTIVGVSGDVSDMQHIEYLLDEMKIENNYDNSSPDDEEALQPSYVFEYLAAVMYQRRSKMDPLWNAVIVAGIEKDGSPFLRYVNLLGVTYSSPTLATGFGAHLAIPLLRRVIDKETDIEKTDLALAEQTIRESMKVLFYRDARSSKKYSLAIIDKDKGLMFKQNQEVENMSWKFAKDIKGYGTQKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXZ0</accession>
    <name>RL30_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein eL30</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPL30</name>
        <name type="ordered locus">CAGL0A01540g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444832.1">
        <property type="nucleotide sequence ID" value="XM_444832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXZ0"/>
    <dbReference type="SMR" id="Q6FXZ0"/>
    <dbReference type="FunCoup" id="Q6FXZ0">
        <property type="interactions" value="1347"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXZ0"/>
    <dbReference type="EnsemblFungi" id="CAGL0A01540g-T">
        <property type="protein sequence ID" value="CAGL0A01540g-T-p1"/>
        <property type="gene ID" value="CAGL0A01540g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886362"/>
    <dbReference type="KEGG" id="cgr:2886362"/>
    <dbReference type="CGD" id="CAL0126731">
        <property type="gene designation" value="CAGL0A01540g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_A01540g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01540g"/>
    <dbReference type="eggNOG" id="KOG2988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130502_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FXZ0"/>
    <dbReference type="OMA" id="YFQGGNN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048025">
        <property type="term" value="P:negative regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000146137" description="Large ribosomal subunit protein eL30">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="105" mass="11369" checksum="9330955080C7502A" modified="2004-07-19" version="1">MAPIKTQESINQKLALVVKSGKFTLGYKSTIKSLRQGKSKLIIIAANTPVLRKSELEYYAMLSKTKVYYFQGGNNELGTAVGKLFRVGVVSVLDAGDSDILTALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FYA8</accession>
    <name>Q6FYA8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ammonia transport outward protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0A03212g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FYA8"/>
    <dbReference type="FunCoup" id="Q6FYA8">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FYA8"/>
    <dbReference type="KEGG" id="cgr:2886332"/>
    <dbReference type="CGD" id="CAL0126709">
        <property type="gene designation" value="CAGL0A03212g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A03212g"/>
    <dbReference type="eggNOG" id="ENOG502QSVX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FYA8"/>
    <dbReference type="OMA" id="CINTDQF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF3">
        <property type="entry name" value="AMMONIA TRANSPORT OUTWARD PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0126709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG57800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29609" checksum="7F87FBC20B7DB1A5" modified="2004-07-19" version="1">MSSSSSQIDIEKAPVTMEKAVSLPGVTVSESRSQPIQEIYADSEFVTLGGYTYRRTQLLTALGIDEHREQHTPVVKKLANPVPLGLASFSICCLVLSLINANVRGVTSNQFVISMYMLFGGAIELFAGLLCFVIGDTFSMTVFSSFGGFWLSYGLDFVPSMAAISEYDKDPNMLNNVIGFYLAAWCVFTFLMLMCCLKSAWGLFLLLFFLDFTFLMLCIGNFINDNNCKMAGGYFGILASVCGFYMLYCCVSSKENSYVPLRAIMMPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN47</accession>
    <name>B4UN47_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0L04836g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAR58063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002999590.1">
        <property type="nucleotide sequence ID" value="XM_002999544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN47"/>
    <dbReference type="KEGG" id="cgr:9488041"/>
    <dbReference type="CGD" id="CAL0135946">
        <property type="gene designation" value="CAGL0L04836g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04836g"/>
    <dbReference type="HOGENOM" id="CLU_2867455_0_0_1"/>
    <dbReference type="InParanoid" id="B4UN47"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0135946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR58063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="64" mass="6695" checksum="A9D8DC24C96EEC27" modified="2008-09-23" version="1">MGIEGSQGSGQRKELACPANASLPGSSLLTIPSTLGPYHKPVLHGMGTEVSHCKALRFFRSEVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1999-07-15" modified="2025-06-18" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>O74234</accession>
    <accession>Q6FY92</accession>
    <name>NMT_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber>2.3.1.97</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Myristoyl-CoA:protein N-myristoyltransferase</fullName>
            <shortName>NMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Peptide N-myristoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NMT1</name>
        <name type="ordered locus">CAGL0A04059g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1998-06" db="EMBL/GenBank/DDBJ databases">
            <title>Isolation of the gene encoding the myristoyl-CoA:protein N-myristoyltransferase from the pathogenic yeast, Candida glabrata.</title>
            <authorList>
                <person name="Hosking S.L."/>
                <person name="Massey S.E."/>
                <person name="Egerton M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NMT family.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="frameshift">
            <sequence resource="EMBL-CDS" id="AAC26048" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.3.1.97"/>
    <dbReference type="EMBL" id="AF073886">
        <property type="protein sequence ID" value="AAC26048.1"/>
        <property type="status" value="ALT_FRAME"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444943.1">
        <property type="nucleotide sequence ID" value="XM_444943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O74234"/>
    <dbReference type="SMR" id="O74234"/>
    <dbReference type="FunCoup" id="O74234">
        <property type="interactions" value="993"/>
    </dbReference>
    <dbReference type="STRING" id="284593.O74234"/>
    <dbReference type="EnsemblFungi" id="CAGL0A04059g-T">
        <property type="protein sequence ID" value="CAGL0A04059g-T-p1"/>
        <property type="gene ID" value="CAGL0A04059g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886412"/>
    <dbReference type="KEGG" id="cgr:2886412"/>
    <dbReference type="CGD" id="CAL0126631">
        <property type="gene designation" value="NMT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_A04059g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04059g"/>
    <dbReference type="eggNOG" id="KOG2779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022882_2_0_1"/>
    <dbReference type="InParanoid" id="O74234"/>
    <dbReference type="OMA" id="GWKRDWH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000064237" description="Glycylpeptide N-tetradecanoyltransferase">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; via carboxylate" evidence="1">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="175"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC26048." evidence="3" ref="1">
        <original>Y</original>
        <variation>F</variation>
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P14743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="451" mass="52659" checksum="514364B1FE3A2CC9" modified="2004-08-31" version="2">MSEKKIEELLKLLSMNNGDMSKLTANQRKEMKEYKFWKTQPVTKFDEEVKEEGPIHEEKTPADIPDEPLPLLPDFEWCAIDVDDEKQLEDVFVLLNENYVEDRDASFRFNYTREFFNWALKSPGWTPDWHIGVRVKASKKLIAFISAIPVRLRVRAKVIDSVEINFLCVHKQLRSKRLTPVLIKEITRRVNKRNIWHALYTAGVVLPAPVSTCRYAHRPLNWDKLYEVQFTDLPPNATKAEMVAKYTLPKATKTAGLRELRLEDVDQALALFNRYQSRFDIVQEFTKEEFIHWFINDKNVVEQDKRVVFSYVVESEGKVTDFFSFYSLPFTILNNSRYKDLGIGYLYYYASDADFKFEDRFDKEGTSLLKQRLSTLVQDACIIAAQNKMDVFNALSSQDNTLFLEDLKFGPGDGFLNFYLFNYRTFPITGGLTEDQHFDTEHRSNVGVVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIL7</accession>
    <name>Q6FIL7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M13431g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIL7"/>
    <dbReference type="FunCoup" id="Q6FIL7">
        <property type="interactions" value="1310"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIL7"/>
    <dbReference type="KEGG" id="cgr:2891218"/>
    <dbReference type="CGD" id="CAL0137011">
        <property type="gene designation" value="CAGL0M13431g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13431g"/>
    <dbReference type="eggNOG" id="ENOG502QQIZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050414_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FIL7"/>
    <dbReference type="OMA" id="VIYVSFE"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0137011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="307" mass="34477" checksum="EC42541418C08138" modified="2004-07-19" version="1">MASSTHNPSVLLKRILSLTEPAPLLLVSDTLAQSSYFLVQEVIHNVQEYQKSKNSGVIVFVAFETVNKPRYTDIFIDASKVGFTKLPEAISSFLPTPQTPVNTSCRNVIVIDSLNHVPRAQLTKFIGSIATPHATILATLHRDMHDSPYEHGLDNYPSAIELLHFMATTSLDVTPASTISDDDELNQQLSKLQIPRGLNNTTFKVSLTYKRKSGRELTYDFKVDYNTHQYYQIMDKKDVDENALETPEMLQGLTTFNLSTSAKQKAAKDQVELPFLEAQSLTAGGAIVYEYEKDDDYDEEDPYEDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJF0</accession>
    <name>Q6FJF0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CRZ1</name>
        <name evidence="14 15" type="ordered locus">CAGL0M06831g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449644.1">
        <property type="nucleotide sequence ID" value="XM_449644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJF0"/>
    <dbReference type="SMR" id="Q6FJF0"/>
    <dbReference type="FunCoup" id="Q6FJF0">
        <property type="interactions" value="856"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJF0"/>
    <dbReference type="GeneID" id="2891693"/>
    <dbReference type="KEGG" id="cgr:2891693"/>
    <dbReference type="CGD" id="CAL0137005">
        <property type="gene designation" value="CRZ1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06831g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030450_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJF0"/>
    <dbReference type="OMA" id="CILPLYE"/>
    <dbReference type="PHI-base" id="PHI:2561"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000181">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000239">
        <property type="entry name" value="C2H2 type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002218">
        <property type="entry name" value="Transcriptional regulator CRZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="577"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="426"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0137005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG62620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="645" mass="72065" checksum="81B773C707D0EC46" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJI1</accession>
    <name>Q6FJI1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translocation protein SEC66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M06127g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJI1"/>
    <dbReference type="FunCoup" id="Q6FJI1">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJI1"/>
    <dbReference type="KEGG" id="cgr:2891661"/>
    <dbReference type="CGD" id="CAL0137495">
        <property type="gene designation" value="CAGL0M06127g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06127g"/>
    <dbReference type="eggNOG" id="KOG4699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066294_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FJI1"/>
    <dbReference type="OMA" id="DYWQRYQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071256">
        <property type="term" value="C:translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26538" checksum="A930418009362F1F" modified="2004-07-19" version="1">MDQEFFNATDFNGTNGTQFENNGTRFDNGTHGNGTFFEEPQVEMKAVSFYTPLLYVSLLVISLFIFASQYRKNKIKKISELPSIFDESDAKDLYMDLLKLQKSGDKKIHEKVLKAGLLNRCAEAIRRSLKLKEMAPQVEILYKNGSIGDDYWQRYQTEVKLVDVEFKECIQESERLQPGWVPTFVPLAREICLNQALSRRYNAIATRREVCIEEWGLKLDKDGKLISSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJL8</accession>
    <name>Q6FJL8_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M05291g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJL8"/>
    <dbReference type="FunCoup" id="Q6FJL8">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJL8"/>
    <dbReference type="KEGG" id="cgr:2891623"/>
    <dbReference type="CGD" id="CAL0136801">
        <property type="gene designation" value="CAGL0M05291g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05291g"/>
    <dbReference type="eggNOG" id="KOG0264">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020445_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FJL8"/>
    <dbReference type="OMA" id="MPQNPDV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="5">
        <location>
            <begin position="234"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="332"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="419" mass="47199" checksum="0A0F75E92734ED49" modified="2004-07-19" version="1">MDADNIEDIEEQPVSTIPEDVQTRYIHWKKNTKLLYDYLNTNSTKWPSLTCQFFPDLDTSSDQHRLLLSSFTSSQLPEDESVYISKISTLKHLNWSSLNNFDMDEMEFKPDPSVKLPPKNLTTEVSIRFPNGDCNRSRYLPQNPDLIAAASSDGSVYIFNKTKHGNSVLRSKSSDDFQARLFSGSHDAQNLDNFNEAVSLSWNKHKEGILGVSYSQGQCNIWDVKKFSRSNILISQPELTVTFDSNGCNDLDWMPMHDSMFIACGESNKLGLFDMRLNGEKEVNSISNYKHEDGINTCKFNPGNSLLVASADTCGRINLWDIRKLDQEPISTMQHGSSISTIEWNPNIGVVFASAGQEDGLVKLWDASVGKEIFVHGGHMLGVNDISWDMHDPWLMASVSNDNTIQIWRPAKNIVSKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJN2</accession>
    <name>Q6FJN2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M04939g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJN2"/>
    <dbReference type="FunCoup" id="Q6FJN2">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJN2"/>
    <dbReference type="KEGG" id="cgr:2891572"/>
    <dbReference type="CGD" id="CAL0137373">
        <property type="gene designation" value="CAGL0M04939g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04939g"/>
    <dbReference type="eggNOG" id="KOG1946">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046065_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FJN2"/>
    <dbReference type="OMA" id="TMFALNK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.245.10:FF:000004">
        <property type="entry name" value="Upstream activation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DEK-C" evidence="7">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="6">
        <location>
            <begin position="134"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="233" mass="26903" checksum="A1031BBFE7C7BBE5" modified="2004-07-19" version="1">MDQNIDLNNYVSMLDAIISVSDPDKVSPKKIRKALEQLFSVSLENKKKEVNELIVARFQILQADPHILVSNEEFQNLKMIRGNYDALLSSKSMEKKHKLTESSKKTRIQVKKKKSKKSSKDGEKKVANPNSNAINSMKLRLSDDLYKFLGERELPRTQVVKQVWDYIKEHNLQSPEDRREIICDDRMRPIFGDKMTMFALNKILSKHLTKIEPKSEEADNSRLSVKLEDGTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJZ4</accession>
    <name>Q6FJZ4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peroxisomal long-chain fatty acid import protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PXA1</name>
        <name evidence="12 13" type="ordered locus">CAGL0M02387g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449450.1">
        <property type="nucleotide sequence ID" value="XM_449450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJZ4"/>
    <dbReference type="FunCoup" id="Q6FJZ4">
        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJZ4"/>
    <dbReference type="GeneID" id="2891458"/>
    <dbReference type="KEGG" id="cgr:2891458"/>
    <dbReference type="CGD" id="CAL0136605">
        <property type="gene designation" value="PXA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02387g"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FJZ4"/>
    <dbReference type="OMA" id="IHDMYLD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015916">
        <property type="term" value="P:fatty-acyl-CoA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042758">
        <property type="term" value="P:long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="201"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="582"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="822"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0136605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG62426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="97925" checksum="DE0246221116E724" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKD6</accession>
    <name>TRM44_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber>2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TRM44</name>
        <name type="ordered locus">CAGL0L12408g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM44 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449308.1">
        <property type="nucleotide sequence ID" value="XM_449308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKD6"/>
    <dbReference type="FunCoup" id="Q6FKD6">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKD6"/>
    <dbReference type="EnsemblFungi" id="CAGL0L12408g-T">
        <property type="protein sequence ID" value="CAGL0L12408g-T-p1"/>
        <property type="gene ID" value="CAGL0L12408g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890698"/>
    <dbReference type="KEGG" id="cgr:2890698"/>
    <dbReference type="CGD" id="CAL0135228">
        <property type="gene designation" value="CAGL0L12408g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12408g"/>
    <dbReference type="eggNOG" id="KOG3790">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018580_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FKD6"/>
    <dbReference type="OMA" id="IREPNIN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000249903" description="tRNA (uracil-O(2)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="564" mass="64342" checksum="EC39E4AF4C619FD9" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL24</accession>
    <name>Q6FL24_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">eRF1/Pelota-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0L06754g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL24"/>
    <dbReference type="FunCoup" id="Q6FL24">
        <property type="interactions" value="1434"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL24"/>
    <dbReference type="KEGG" id="cgr:2890815"/>
    <dbReference type="CGD" id="CAL0135242">
        <property type="gene designation" value="CAGL0L06754g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06754g"/>
    <dbReference type="eggNOG" id="KOG0688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035759_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FL24"/>
    <dbReference type="OMA" id="GPGTEKM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="5">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0135242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="438" mass="49258" checksum="9EBAD4CBEE5B7AF9" modified="2004-07-19" version="1">MDTDAEKNIEIWKVKKLVRSLEQARGNGTSMISLVIPPKGQIPLVQKMLTEEYGTASNIKSRVNRLSVLSAITSTQQKLKLYNSLPPNGLVLYCGDIITEDGKEKKVTFDIEPYKPINTSLYLCDNKFHTEVLSELLEADDKFGFIVMDGQGALFGLLQGNTRSVLHKFTVDLPKKHGRGGQSAVRFARLREEKRHNYVRKVAEVAVQNFITNDKVNVKGLILAGSADFKTDLAKSELFDQRLAAKVVQIVDISYGGENGFNQAIELSADALANVKFVQEKKLLDEYFDEISQDTGKFCYGIDDTLKALDLGAVEKLIVFENLETIRYTFKDSEDNEVIRFAEPKAKDKSYAVDKATGQEMEVVTEQPLIEWLAENYKNFGAALEFITDKSQEGSQFVTGFGGIGALLRYKVNFEQLVDESEDEYYDDDEVESDYDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL89</accession>
    <name>Q6FL89_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0L05302g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL89"/>
    <dbReference type="FunCoup" id="Q6FL89">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL89"/>
    <dbReference type="KEGG" id="cgr:2890784"/>
    <dbReference type="CGD" id="CAL0135774">
        <property type="gene designation" value="CAGL0L05302g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05302g"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014402_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FL89"/>
    <dbReference type="OMA" id="HEIQINT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990143">
        <property type="term" value="C:CoA-synthesizing protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="270"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0135774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG61975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="544" mass="60359" checksum="3EF6B512B3445E25" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL98</accession>
    <name>Q6FL98_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAGL0L05104g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL98"/>
    <dbReference type="FunCoup" id="Q6FL98">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL98"/>
    <dbReference type="KEGG" id="cgr:2890721"/>
    <dbReference type="eggNOG" id="KOG0240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_32_0_1"/>
    <dbReference type="InParanoid" id="Q6FL98"/>
    <dbReference type="OMA" id="DMNVEHE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="6">
        <location>
            <begin position="29"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="586"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="423"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="524"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="126"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="675" mass="75955" checksum="3F3B5126763B274A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLG5</accession>
    <name>Q6FLG5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SIT4-associating protein SAP190</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0L03586g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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    </reference>
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        <text evidence="1">Belongs to the SAPS family.</text>
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        <property type="term" value="F:protein phosphatase binding"/>
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        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:tRNA wobble uridine modification"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="SAPS"/>
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        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
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    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLY8</accession>
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        <recommendedName>
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        </recommendedName>
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        <name type="common">Yeast</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        <property type="term" value="F:mating-type alpha-factor pheromone receptor activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="GPCRSTE2"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="62"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0134079"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG61719.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="47293" checksum="C962156FD72E5CF0" modified="2004-07-19" version="1">MEMGYDPRMYNPRNEYLNFTSVYDVNDTIRFSTLDAIVKGLLRIAIVHGVRLGAIFMTLIIMFISSNTWKKPIFIINMVSLMLVMIHSALSFHYLLSNYSSISYILTGFPQLITSNNKRIQDAASIVQVLLVAAIEASLVFQIHVMFTIENIKLIREIVLSISIAMGLATVATYLAAAIKLIRGLHDEVMPQTHLIFNLSIILLASSINFMTFILVIKLFFAIRSRRYLGLRQFDAFHILLIMFCQSLLIPSVLYIIVYAVDSRSNQDYLIPIANLFVVLSLPLSSIWANTSNNSSRSPKYWKNSQTNKSNGSFVSSISVNSDSQNPLYKKIVRFTSKGDTTRSIVSDSTLAEVGKYSMQDVSNSNFECRDLDFEKVKHTCENFGRISETYSELSTLDTTALNETRLFWKQQSQCDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLZ0</accession>
    <name>EPL1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Enhancer of polycomb-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EPL1</name>
        <name type="ordered locus">CAGL0K12386g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448754.1">
        <property type="nucleotide sequence ID" value="XM_448754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLZ0"/>
    <dbReference type="SMR" id="Q6FLZ0"/>
    <dbReference type="FunCoup" id="Q6FLZ0">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLZ0"/>
    <dbReference type="EnsemblFungi" id="CAGL0K12386g-T">
        <property type="protein sequence ID" value="CAGL0K12386g-T-p1"/>
        <property type="gene ID" value="CAGL0K12386g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889983"/>
    <dbReference type="KEGG" id="cgr:2889983"/>
    <dbReference type="CGD" id="CAL0134065">
        <property type="gene designation" value="CAGL0K12386g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12386g"/>
    <dbReference type="eggNOG" id="KOG2261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010580_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLZ0"/>
    <dbReference type="OMA" id="MLGTKSY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032777">
        <property type="term" value="C:piccolo histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000214158" description="Enhancer of polycomb-like protein 1">
        <location>
            <begin position="1"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="821" mass="94601" checksum="E62688EF63CA7619" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM14</accession>
    <name>Q6FM14_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0K11836g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM14"/>
    <dbReference type="FunCoup" id="Q6FM14">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM14"/>
    <dbReference type="KEGG" id="cgr:2890534"/>
    <dbReference type="CGD" id="CAL0134967">
        <property type="gene designation" value="CAGL0K11836g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11836g"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042821_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM14"/>
    <dbReference type="OMA" id="WNSEGSE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="188"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="522" mass="57330" checksum="EBB30DE02BAF331F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM21</accession>
    <name>Q6FM21_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0K11660g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM21"/>
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        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM21"/>
    <dbReference type="KEGG" id="cgr:2890526"/>
    <dbReference type="CGD" id="CAL0134227">
        <property type="gene designation" value="CAGL0K11660g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11660g"/>
    <dbReference type="eggNOG" id="ENOG502S2CK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104695_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FM21"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP9" evidence="2">
        <location>
            <begin position="3"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0134227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="187" mass="20619" checksum="9DB8F1BA3C748C64" modified="2004-07-19" version="1">MSVKPIDTFIENSVKLFEANPSGSSITISYHGGAKADPVVFRTHNPHLSTTYKYQTKMNKEVSRVLNALGPRGVSMNPISKIAKRRNYLDVVKKAKQMNNSKISKKQAKLIRKAQTNPIVNTIGIGKLIANEDIKEVKTESTSGGAGNKKTKQKKNKNNKDSTPVVNTSANAQSKGKNKKNKNKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMH0</accession>
    <name>Q6FMH0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0K08118g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMH0"/>
    <dbReference type="KEGG" id="cgr:2890342"/>
    <dbReference type="CGD" id="CAL0134083">
        <property type="gene designation" value="CAGL0K08118g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08118g"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007739_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FMH0"/>
    <dbReference type="OMA" id="QLWQDPE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="314"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0134083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1055" mass="122611" checksum="7861E501A2F3EEB2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMH2</accession>
    <name>Q6FMH2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-mRNA-splicing factor RDS3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K08074g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMH2"/>
    <dbReference type="FunCoup" id="Q6FMH2">
        <property type="interactions" value="993"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMH2"/>
    <dbReference type="KEGG" id="cgr:2890340"/>
    <dbReference type="CGD" id="CAL0133901">
        <property type="gene designation" value="CAGL0K08074g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08074g"/>
    <dbReference type="eggNOG" id="KOG1705">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110369_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FMH2"/>
    <dbReference type="OMA" id="AYYCWEC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11935" checksum="07E637E5FEB989E5" modified="2004-07-19" version="1">MSRHQSDLMMCMNPAGINTGILCEKCDGRCPSCDSYVRPRSRVTVCDQCSFGKQATQCILCGSTNGKVPAYYCWECCKLGKNRKGCPRIINIGSNKMDRYFGTKKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMK6</accession>
    <name>Q6FMK6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein GIS4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K07271g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMK6"/>
    <dbReference type="FunCoup" id="Q6FMK6">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890399"/>
    <dbReference type="CGD" id="CAL0134497">
        <property type="gene designation" value="CAGL0K07271g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07271g"/>
    <dbReference type="eggNOG" id="ENOG502QVAT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016359_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMK6"/>
    <dbReference type="OMA" id="NHENHYL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="87425" checksum="00FBF17D79D21A55" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMS1</accession>
    <name>Q6FMS1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0K05687g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448473.1">
        <property type="nucleotide sequence ID" value="XM_448473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMS1"/>
    <dbReference type="STRING" id="284593.Q6FMS1"/>
    <dbReference type="KEGG" id="cgr:2890466"/>
    <dbReference type="CGD" id="CAL0134121">
        <property type="gene designation" value="CAGL0K05687g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05687g"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FMS1"/>
    <dbReference type="OMA" id="YNPRWPW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="41"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="388" mass="43436" checksum="08A8587AFC7B06BF" modified="2004-07-19" version="1">MGVSVKGAPNLDYFTPEQPILGKFIKYKEDEDGSSERDPPKLFKPLKIRALEIPNRIGVSPMCTYSTNNYMPTDFHLMHYGSLATRGPGIIIVECSAVSEGTAVTVNDMGIWNKEQASEHFSKIVKFAHSQNVIVGCQLGQFMRKVVQNVDEDNKAHNVEVGKEAHDLSTEEIKTIVEQWGTAAKLAVEVAKYDFIEIQAGKGHITNEFFSRLTNKRKDEYGGSFENRIRILLEIIDNVRKNIPEDTPLFIRLKACDNLDHPDAWSTDETIKLSFELAKHGVDVLDIAGRGLRIGPKSEKENKIIFLQQLKEAHKGKTNLLIASSGVISTADYASELLDKEAQDIILVGRPFLKNPNLVSFWADDVNITVTNAVQYSWGFYPTKSHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMS7</accession>
    <name>Q6FMS7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bud site selection protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K05555g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMS7"/>
    <dbReference type="FunCoup" id="Q6FMS7">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMS7"/>
    <dbReference type="KEGG" id="cgr:2890491"/>
    <dbReference type="CGD" id="CAL0134195">
        <property type="gene designation" value="CAGL0K05555g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05555g"/>
    <dbReference type="eggNOG" id="ENOG502S51X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077704_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMS7"/>
    <dbReference type="OMA" id="IRSKDRW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013268">
        <property type="entry name" value="UTP16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08297">
        <property type="entry name" value="U3_snoRNA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="26500" checksum="56295FA0F5E255E0" modified="2004-07-19" version="1">MTVSTRSKEHIKFDDNDETAHTETETQESVKSLRSKSVDVSDSDSDSDDDAPEEEGLGNAKDEVEDQIKKQEQAAILEKQRIREKRKKENERLKEQQLEKKMRTEEMQKQIAELEKLQSQTVESDEEELQELPEDLLAKINNVDPTAGQTIPKHINFNDIDTQDFVPEVKEQIKKRKKNALKQLCKTTMNKGVVKVSVLSSNLSKSAPKKEGNVTNLRNKWLKRRSLNRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN53</accession>
    <name>STE20_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein kinase STE20</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">STE20</name>
        <name type="ordered locus">CAGL0K02673g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Yeast" volume="21" first="557" last="568">
            <title>Candida glabrata Ste20 is involved in maintaining cell wall integrity and adaptation to hypertonic stress, and is required for wild-type levels of virulence.</title>
            <authorList>
                <person name="Calcagno A.-M."/>
                <person name="Bignell E."/>
                <person name="Rogers T.R."/>
                <person name="Canedo M."/>
                <person name="Muehlschlegel F.A."/>
                <person name="Haynes K."/>
            </authorList>
            <dbReference type="PubMed" id="15164359"/>
            <dbReference type="DOI" id="10.1002/yea.1125"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity). Involved in cell wall integrity, hypertonic stress adaptation and virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448341.1">
        <property type="nucleotide sequence ID" value="XM_448341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN53"/>
    <dbReference type="SMR" id="Q6FN53"/>
    <dbReference type="FunCoup" id="Q6FN53">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN53"/>
    <dbReference type="EnsemblFungi" id="CAGL0K02673g-T">
        <property type="protein sequence ID" value="CAGL0K02673g-T-p1"/>
        <property type="gene ID" value="CAGL0K02673g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890268"/>
    <dbReference type="KEGG" id="cgr:2890268"/>
    <dbReference type="CGD" id="CAL0134517">
        <property type="gene designation" value="STE20"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02673g"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_26_3_1"/>
    <dbReference type="InParanoid" id="Q6FN53"/>
    <dbReference type="OMA" id="YNAKHVH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044025">
        <property type="term" value="F:histone H2BS14 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007121">
        <property type="term" value="P:bipolar cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000910">
        <property type="term" value="P:negative regulation of sterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035376">
        <property type="term" value="P:sterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000007">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
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    </dbReference>
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        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PAK3-like"/>
    </dbReference>
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        <property type="entry name" value="PAK_BD"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0589">Pheromone response</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000237628" description="Serine/threonine-protein kinase STE20">
        <location>
            <begin position="1"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="620"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="894"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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            <end position="598"/>
        </location>
    </feature>
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        <location>
            <begin position="895"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="626"/>
            <end position="634"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="649"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00057"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="15164359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="915" mass="100411" checksum="4CC3CBE4C4CCC0EA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNC5</accession>
    <name>Q6FNC5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">37S ribosomal protein MRP13, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K01023g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="gene designation" value="CAGL0K01023g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01023g"/>
    <dbReference type="eggNOG" id="ENOG502RYVU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_894829_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNC5"/>
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    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="mS44"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MRP13_sacc"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="37446" checksum="980294D727084112" modified="2004-07-19" version="1">MLKNCSRFYSAVAKSNKQLLDEFYQYHTTRMNLRPLIYRPKNATLLRSMDLKDPETNKPIQPREPMKPLKKQVLNNYVQEIPQGSKELMDFLQKWFKVSNRKRELFAFLEGSHLQVMLAASLFRIGHYSHVLGLLHSYQSKVVGTGNTKAYDQDRFFNTVLMCSLLRNDLKDLKDAEIGLKKLKVNWGKVTEKNDTLGLTQPLLEAYANQQGISKEDLVLKGRETISNINLPSIGDESRFSRLVTFITENKYTYFLARTIQKFSESCPSEIETFINEYKNALTTLKKDDEYDWSVQNMTEVNKIPEETKQERETQEETQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNF2</accession>
    <name>Q6FNF2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K00407g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNF2"/>
    <dbReference type="FunCoup" id="Q6FNF2">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNF2"/>
    <dbReference type="KEGG" id="cgr:2890188"/>
    <dbReference type="CGD" id="CAL0134027">
        <property type="gene designation" value="CAGL0K00407g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00407g"/>
    <dbReference type="eggNOG" id="KOG3188">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060791_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNF2"/>
    <dbReference type="OMA" id="KDMDPRW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045050">
        <property type="term" value="P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="269" mass="30392" checksum="2DEEB32CD3785180" modified="2004-07-19" version="1">MWFDWVWTAVTISGSHVVDELTLDTRLKYWVLLPISVVMVLAGILRHYVMSLLNPSVKGTARVKLTENQYVLKAQVLLGNNSSLSDEAFEVRREYMAQLLSSGKYIAQTNAKPGEVVNPFSDPNISDAMMNMAKGNMAQFIPQTVLMWWVNHFFAGFVLMKLPFPLTIRFKEMLQSGVMTSDLDVRWVSSISWYFISVLGLNPVYNLILAEPEEDQLGMMQQQQPDQMMGGPGAPQPEAVMKGLANDLTIAQHESCFDNIESRILKMYS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNM7</accession>
    <name>SSN2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SSN2</name>
        <name type="synonym">MED13</name>
        <name type="ordered locus">CAGL0J10472g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448167.1">
        <property type="nucleotide sequence ID" value="XM_448167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNM7"/>
    <dbReference type="SMR" id="Q6FNM7"/>
    <dbReference type="FunCoup" id="Q6FNM7">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNM7"/>
    <dbReference type="EnsemblFungi" id="CAGL0J10472g-T">
        <property type="protein sequence ID" value="CAGL0J10472g-T-p1"/>
        <property type="gene ID" value="CAGL0J10472g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889605"/>
    <dbReference type="KEGG" id="cgr:2889605"/>
    <dbReference type="CGD" id="CAL0132930">
        <property type="gene designation" value="CAGL0J10472g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10472g"/>
    <dbReference type="eggNOG" id="KOG3600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_242296_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNM7"/>
    <dbReference type="OMA" id="FSRELWC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990508">
        <property type="term" value="C:CKM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000314247" description="Mediator of RNA polymerase II transcription subunit 13">
        <location>
            <begin position="1"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1345" mass="151209" checksum="E99C8B215112B0AE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNN7</accession>
    <name>IMP4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
            <shortName>U3 snoRNP protein IMP4</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">IMP4</name>
        <name type="ordered locus">CAGL0J10252g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the U3 small nucleolar ribonucleoprotein. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of a heterotrimeric complex containing IMP3, IMP4 and MPP10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448157.1">
        <property type="nucleotide sequence ID" value="XM_448157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNN7"/>
    <dbReference type="SMR" id="Q6FNN7"/>
    <dbReference type="FunCoup" id="Q6FNN7">
        <property type="interactions" value="982"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNN7"/>
    <dbReference type="EnsemblFungi" id="CAGL0J10252g-T">
        <property type="protein sequence ID" value="CAGL0J10252g-T-p1"/>
        <property type="gene ID" value="CAGL0J10252g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889416"/>
    <dbReference type="KEGG" id="cgr:2889416"/>
    <dbReference type="CGD" id="CAL0133444">
        <property type="gene designation" value="CAGL0J10252g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J10252g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10252g"/>
    <dbReference type="eggNOG" id="KOG2781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040063_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FNN7"/>
    <dbReference type="OMA" id="IGTMSEQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140691">
        <property type="term" value="F:RNA folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000120241" description="U3 small nucleolar ribonucleoprotein protein IMP4">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="84"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00034"/>
        </source>
    </evidence>
    <sequence length="288" mass="33143" checksum="4401FD3548C343B0" modified="2004-07-19" version="1">MLRRQARERREYLYRKAQELQETQLQQKRQIIKQALAQGKPLPKELAEDEQLQKDFRYDQSMADNEDEAGVDDEYSASSGIVEARVIVTTSRDPSSRLAQFAKEIKLLFPNAVRLNRGNYVMADLVSACKKSGTTDLIVLHEHRGVPTSLTVSHFPYGPTAFFSLHNVVLRHDILNRGNQSEVNPHLIFDNFTTPLGNRVVTILKNLFPPGPKKDSSRVITFANRGDFISVRQHVYVRTKDGVEMAEVGPRFEMRLFELRLGTLENKDADVEWQLRRFVRTANRKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNS3</accession>
    <name>Q6FNS3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RecQ mediated genome instability protein 1 OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J09482g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNS3"/>
    <dbReference type="FunCoup" id="Q6FNS3">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNS3"/>
    <dbReference type="KEGG" id="cgr:2889934"/>
    <dbReference type="CGD" id="CAL0133438">
        <property type="gene designation" value="CAGL0J09482g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09482g"/>
    <dbReference type="eggNOG" id="KOG3683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100701_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNS3"/>
    <dbReference type="OMA" id="CEYLEAK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="1">
        <location>
            <begin position="57"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="233" mass="26265" checksum="BC162835E77A9A57" modified="2004-07-19" version="1">MSLSDILPNDITTITSLGSFKATPGTRENTIYQALCNVPWLDGLGRAQIIETKMLAVDRDLLFQIMMVENISKSKVTQIDDMKTTIDPRNQRVDRLHNSNPNGPSKKYKVINEVNIEEDDGNGSTESNGVIGGEKVMYKLTLQSRSGQIFYAINLKPISWPLAVLGSKIVIKKGTKFSRGMFLLAEDNAIFVGGMVKKWNEDKDLKILEYLETKANKENERLQALKDSRKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP90</accession>
    <name>Q6FP90_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Processing of GAS1 and ALP protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J05720g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP90"/>
    <dbReference type="FunCoup" id="Q6FP90">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP90"/>
    <dbReference type="KEGG" id="cgr:2889803"/>
    <dbReference type="CGD" id="CAL0132982">
        <property type="gene designation" value="CAGL0J05720g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05720g"/>
    <dbReference type="eggNOG" id="ENOG502S88B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150165_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP90"/>
    <dbReference type="OMA" id="FGWGNKT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199:SF1">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022909">
        <property type="entry name" value="UCP022909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="16391" checksum="C0B788645496F371" modified="2004-07-19" version="1">MERISKIFENSIDNILSIEPRKALRIVIIVGAYMLFRNLVTRDQNRRQLARQVRQEEERKKEEREKTLLERPEDFEVETIAKSSTTEYGWGKKTRQRVKRQQEVLERAVDDLKRHEQLKLSGTGYDSDEEIEELLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPU9</accession>
    <name>Q6FPU9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP192</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J00759g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUP186/NUP192/NUP205 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FPU9">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPU9"/>
    <dbReference type="KEGG" id="cgr:2889866"/>
    <dbReference type="CGD" id="CAL0133694">
        <property type="gene designation" value="CAGL0J00759g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J00759g"/>
    <dbReference type="eggNOG" id="KOG1835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002778_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPU9"/>
    <dbReference type="OMA" id="AYGFIEW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046822">
        <property type="term" value="P:regulation of nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021827">
        <property type="entry name" value="Nup186/Nup192/Nup205"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31344:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11894">
        <property type="entry name" value="Nup192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0133694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1710" mass="195272" checksum="49155177F90EFC73" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ02</accession>
    <name>Q6FQ02_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0I10406g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ02"/>
    <dbReference type="FunCoup" id="Q6FQ02">
        <property type="interactions" value="987"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ02"/>
    <dbReference type="MEROPS" id="T01.973"/>
    <dbReference type="KEGG" id="cgr:2889241"/>
    <dbReference type="CGD" id="CAL0130249">
        <property type="gene designation" value="CAGL0I10406g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I10406g"/>
    <dbReference type="eggNOG" id="KOG0178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_3_1"/>
    <dbReference type="InParanoid" id="Q6FQ02"/>
    <dbReference type="OMA" id="YVLNDNM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080129">
        <property type="term" value="P:proteasome core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000009">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0130249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="257" mass="28755" checksum="0E4D792F77447AA1" modified="2004-07-19" version="1">MGSRRYDSRTTIFSPEGRLYQVEYALESISHAGTAIGIMTSEGIVLAAERKVTSTLLEQDTSTEKLYKLNDRTTVAVAGLTADAEILINTARIHAQNYLKTYNEEIPVEMLVRKLSDIKQGYTQYGGLRPYGVSFIYAGYDDRYGYQLYTSNPSGNYTGWKAISVGANTSAAQTLLQMDYKDEMTLDDAVELALKTLSKTTDSSSLTYDRLEFATLKKKGETEEFEQKIFKPAEIKQLLIKTGISKKSDEDEDVEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ16</accession>
    <name>Q6FQ16_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0I09900g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ16"/>
    <dbReference type="FunCoup" id="Q6FQ16">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ16"/>
    <dbReference type="KEGG" id="cgr:2889276"/>
    <dbReference type="CGD" id="CAL0129627">
        <property type="gene designation" value="CAGL0I09900g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09900g"/>
    <dbReference type="eggNOG" id="KOG0131">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_21_2_1"/>
    <dbReference type="InParanoid" id="Q6FQ16"/>
    <dbReference type="OMA" id="IVWELMI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000895">
        <property type="entry name" value="Hsh49p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="106"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0129627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="211" mass="24185" checksum="0A900A5236B4364D" modified="2004-07-19" version="1">MSDPEATIYVGNIDTKVTKELLYELFTQVGQVKKVKYPKDKISQEYQGFAFIEFFSTADADYVLNVMNNNVKLYQKVLKIRRSNQAVQKDDANKKHELDASLLPVAKVFVKDIADTVEVRHLTQLFSKFGPLAKTPEVFTVSNGEVRCAFIYFKFYDNADLAIQTLNGQFIMNKKASLEYAFKENGRKNLRYGTEADRILNKEARKNGILK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQJ5</accession>
    <name>MED9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CSE2</name>
        <name type="synonym">MED9</name>
        <name type="ordered locus">CAGL0I05742g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447499.1">
        <property type="nucleotide sequence ID" value="XM_447499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQJ5"/>
    <dbReference type="SMR" id="Q6FQJ5"/>
    <dbReference type="FunCoup" id="Q6FQJ5">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQJ5"/>
    <dbReference type="EnsemblFungi" id="CAGL0I05742g-T">
        <property type="protein sequence ID" value="CAGL0I05742g-T-p1"/>
        <property type="gene ID" value="CAGL0I05742g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889346"/>
    <dbReference type="KEGG" id="cgr:2889346"/>
    <dbReference type="CGD" id="CAL0130035">
        <property type="gene designation" value="CAGL0I05742g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05742g"/>
    <dbReference type="eggNOG" id="ENOG502S8AG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143643_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQJ5"/>
    <dbReference type="OMA" id="PHIFYAL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21431">
        <property type="entry name" value="Med9-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000304153" description="Mediator of RNA polymerase II transcription subunit 9">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="152" mass="17522" checksum="AA0F1BB6ACC49181" modified="2004-07-19" version="1">MTAPRLISKYRIQIHRISENMVLNNDGLKEISTLLVSASDREPEVKLEKTKDNSSSDITTPPAEFIPSIFFSLHKIRKDPNNVSSQLETSTGFIRHRIKRCKALLQENEEVRNLLANSIEEWENIIADKEQQLRVKAKVLRDLDARIEKITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQJ9</accession>
    <name>Q6FQJ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridine kinase</fullName>
            <ecNumber evidence="6">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0I05654g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 6">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 6">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="6"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQJ9"/>
    <dbReference type="FunCoup" id="Q6FQJ9">
        <property type="interactions" value="877"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQJ9"/>
    <dbReference type="KEGG" id="cgr:2889340"/>
    <dbReference type="CGD" id="CAL0132758">
        <property type="gene designation" value="CAGL0I05654g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05654g"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FQJ9"/>
    <dbReference type="OMA" id="EPQLHCE"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="266"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0132758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="476" mass="53600" checksum="FB34144C5875A40E" modified="2004-07-19" version="1">MHDMTGNSTEARRSSVHLNDQHKYIPPWTTPYIIGVGGTSGSGKTSVANKIVSSINVPWTVLISLDNFYKPLNEAERERAFNNEYDFDEPNAIDLDLAYDCILSLKEGKKTSIPVYSFTHHNRDPHKQIPIYGASVIVLEGIYALYDQRLLDLMDLKVYVDADLDICLARRLSRDIVARGRDLQGCLLQWERYVKPDAVKYVKPTMAKADAIIPSMSDNTVAVKLLIKHIESKLELKSEEHMTELVKLGQSGTGPLSDYKNLEVLPQTNQIKAIHTILLDRNVDRDEFSFQFDRIATLLLANTLNDIPVQKPETIITPDGFSVPGQRRCCFDEVTAISTIRSGDCFMKAVKKAFPAMAIGKLLIQSDSLTGEPQLHCEFIPEDISKYRKILIMDSQIISGAAMIMAVQVLLDHKVDIENIHILVYMATELGIRRIINAFGNRIKITAGIVVERNEIKNKKASWALTRFVDNKYFGC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-10-10" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQN3</accession>
    <name>SNQ2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC multidrug transporter SNQ2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SNQ2</name>
        <name type="ordered locus">CAGL0I04862g</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2001" name="Antimicrob. Agents Chemother." volume="45" first="1174" last="1183">
            <title>Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata.</title>
            <authorList>
                <person name="Sanglard D."/>
                <person name="Ischer F."/>
                <person name="Bille J."/>
            </authorList>
            <dbReference type="PubMed" id="11257032"/>
            <dbReference type="DOI" id="10.1128/AAC.45.4.1174-1183.2001"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="Antimicrob. Agents Chemother." volume="49" first="668" last="679">
            <title>Mechanisms of azole resistance in clinical isolates of Candida glabrata collected during a hospital survey of antifungal resistance.</title>
            <authorList>
                <person name="Sanguinetti M."/>
                <person name="Posteraro B."/>
                <person name="Fiori B."/>
                <person name="Ranno S."/>
                <person name="Torelli R."/>
                <person name="Fadda G."/>
            </authorList>
            <dbReference type="PubMed" id="15673750"/>
            <dbReference type="DOI" id="10.1128/AAC.49.2.668-679.2005"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2008" name="Mol. Microbiol." volume="68" first="186" last="201">
            <title>The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata.</title>
            <authorList>
                <person name="Torelli R."/>
                <person name="Posteraro B."/>
                <person name="Ferrari S."/>
                <person name="La Sorda M."/>
                <person name="Fadda G."/>
                <person name="Sanglard D."/>
                <person name="Sanguinetti M."/>
            </authorList>
            <dbReference type="PubMed" id="18312269"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2008.06143.x"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2014" name="Biofouling" volume="30" first="447" last="457">
            <title>Effects of fluconazole on Candida glabrata biofilms and its relationship with ABC transporter gene expression.</title>
            <authorList>
                <person name="Fonseca E."/>
                <person name="Silva S."/>
                <person name="Rodrigues C.F."/>
                <person name="Alves C.T."/>
                <person name="Azeredo J."/>
                <person name="Henriques M."/>
            </authorList>
            <dbReference type="PubMed" id="24645630"/>
            <dbReference type="DOI" id="10.1080/08927014.2014.886108"/>
        </citation>
        <scope>INDUCTION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2015" name="J. Med. Microbiol." volume="64" first="44" last="52">
            <title>Resistance reversal induced by a combination of fluconazole and tacrolimus (FK506) in Candida glabrata.</title>
            <authorList>
                <person name="Li H."/>
                <person name="Chen Z."/>
                <person name="Zhang C."/>
                <person name="Gao Y."/>
                <person name="Zhang X."/>
                <person name="Sun S."/>
            </authorList>
            <dbReference type="PubMed" id="25355935"/>
            <dbReference type="DOI" id="10.1099/jmm.0.081760-0"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2018" name="Mycoses" volume="61" first="430" last="440">
            <title>CgPDR1 gain-of-function mutations lead to azole-resistance and increased adhesion in clinical Candida glabrata strains.</title>
            <authorList>
                <person name="Ni Q."/>
                <person name="Wang C."/>
                <person name="Tian Y."/>
                <person name="Dong D."/>
                <person name="Jiang C."/>
                <person name="Mao E."/>
                <person name="Peng Y."/>
            </authorList>
            <dbReference type="PubMed" id="29464833"/>
            <dbReference type="DOI" id="10.1111/myc.12756"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">ABC multidrug transporter involved in the response to azoles such as fluconazole, itraconazole, ketoconazole and voriconazole and contributes to the development of PDR1-dependent azole resistance (PubMed:15673750, PubMed:18312269). Plays a role in biofilm tolerance to fluconazole (PubMed:24645630). Also confers resistance to 4-nitroquinoline-N-oxide (4-NQO) (PubMed:18312269).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5 6 7 8 9">Expression is increased in clinical azole-resistant isolates, displaying amounts of transcript increasing from 3.3- to 44.3-fold (PubMed:15673750, PubMed:18312269, PubMed:29464833). Expression is controlled by the pleiotropic drug resistance transcription factor PDR1 (PubMed:18312269, PubMed:29464833). Expression is increased during biofilm growth (PubMed:24645630). The expression levels are significantly down-regulated after exposure to the combination of fluconazole and tacrolimus (FK506) (PubMed:25355935).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="6">Leads to increased susceptibility to fluconazole (PubMed:18312269). Also leads to increased susceptibility to 4-nitroquinoline-N-oxide (4-NQO) (PubMed:18312269).</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447461.1">
        <property type="nucleotide sequence ID" value="XM_447461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQN3"/>
    <dbReference type="SMR" id="Q6FQN3"/>
    <dbReference type="FunCoup" id="Q6FQN3">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQN3"/>
    <dbReference type="GlyCosmos" id="Q6FQN3">
        <property type="glycosylation" value="7 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0I04862g-T">
        <property type="protein sequence ID" value="CAGL0I04862g-T-p1"/>
        <property type="gene ID" value="CAGL0I04862g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889250"/>
    <dbReference type="KEGG" id="cgr:2889250"/>
    <dbReference type="CGD" id="CAL0132132">
        <property type="gene designation" value="SNQ2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I04862g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04862g"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="Q6FQN3"/>
    <dbReference type="OMA" id="FAHRCCG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008559">
        <property type="term" value="F:ABC-type xenobiotic transporter activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001460">
        <property type="entry name" value="ATP-binding cassette transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005285">
        <property type="entry name" value="Drug-R_PDR/CDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00956">
        <property type="entry name" value="3a01205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000445244" description="ABC multidrug transporter SNQ2">
        <location>
            <begin position="1"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="635"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="773"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1193"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1314"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="2">
        <location>
            <begin position="157"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="2">
        <location>
            <begin position="857"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="893"/>
            <end position="900"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="878"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="1311"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="1428"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="15673750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="18312269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="7">
        <source>
            <dbReference type="PubMed" id="24645630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="25355935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="9">
        <source>
            <dbReference type="PubMed" id="29464833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="10">
        <source>
            <dbReference type="PubMed" id="11257032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="11"/>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1507" mass="170187" checksum="AA7D82B795C4A786" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR05</accession>
    <name>Q6FR05_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">OYE2</name>
        <name evidence="6 7" type="ordered locus">CAGL0I02024g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447339.1">
        <property type="nucleotide sequence ID" value="XM_447339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR05"/>
    <dbReference type="STRING" id="284593.Q6FR05"/>
    <dbReference type="GeneID" id="2888949"/>
    <dbReference type="KEGG" id="cgr:2888949"/>
    <dbReference type="CGD" id="CAL0132410">
        <property type="gene designation" value="OYE2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02024g"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR05"/>
    <dbReference type="OMA" id="GKGPVGY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="17"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0132410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="400" mass="45217" checksum="CDBB06BE83E617F1" modified="2004-07-19" version="1">MPFSKDFEPVAFKDTNMFKPMKVGNTTILHRAALPPLTRMRAHHPGHIPNREWAVEYYKQRSQRPGTMLVTEGVFPSAQSGGYDNAPGIWSEEQMVEWRKIFNAVHDNKSFAWVQLWVLGRQGFPDSLARDGLRYDSASDGIYMSAEQEELAKKSNNPQHGITKDEIKQYIKDYVQGAKNAIAAGADGIEIHSANSYLLNQFIDPKSNKRTDEYGGSIENRARFTLEVVDAIVDAIGPERTAIRLSPYGTYGDMSGGAEPLIVAQYAYIIGELERRAKEGKRLAYLHLVEPRVLDPFAPEGEDVYNEGTTDFAYSIWKGPIMRAGNYAIHPEVAMEVLKDDRTIVGYGRYFIANPDLVDRLEKGLPLNKYDRSTFYAMSAEGYIDYPTYEEAIKMGWDKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR11</accession>
    <name>MTC6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Maintenance of telomere capping protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MTC6</name>
        <name type="ordered locus">CAGL0I01892g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MTC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447333.1">
        <property type="nucleotide sequence ID" value="XM_447333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR11"/>
    <dbReference type="FunCoup" id="Q6FR11">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR11"/>
    <dbReference type="GlyCosmos" id="Q6FR11">
        <property type="glycosylation" value="17 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0I01892g-T">
        <property type="protein sequence ID" value="CAGL0I01892g-T-p1"/>
        <property type="gene ID" value="CAGL0I01892g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889110"/>
    <dbReference type="KEGG" id="cgr:2889110"/>
    <dbReference type="CGD" id="CAL0132194">
        <property type="gene designation" value="CAGL0I01892g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I01892g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01892g"/>
    <dbReference type="eggNOG" id="ENOG502QVFP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033723_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR11"/>
    <dbReference type="OMA" id="WGTIDPQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071464">
        <property type="term" value="P:cellular response to hydrostatic pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051008">
        <property type="entry name" value="Telomere_Capping_Maintenance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057530">
        <property type="entry name" value="TIM-barrel_MTC6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518:SF2">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518">
        <property type="entry name" value="MAINTENANCE OF TELOMOERE CAPPING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25506">
        <property type="entry name" value="TIM-barrel_MTC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000407775" description="Maintenance of telomere capping protein 6">
        <location>
            <begin position="19"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="19"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="517"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="548" mass="62477" checksum="30D2BC7640494C4C" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR35</accession>
    <name>UBA4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Adenylyltransferase and sulfurtransferase UBA4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ubiquitin-like protein activator 4</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="2">Adenylyltransferase UBA4</fullName>
                <ecNumber evidence="2">2.7.7.-</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="2">Sulfurtransferase UBA4</fullName>
                <ecNumber evidence="2">2.8.1.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="2" type="primary">UBA4</name>
        <name type="ordered locus">CAGL0I01254g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards URM1. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="2"/>
    <dbReference type="EC" id="2.8.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447309.1">
        <property type="nucleotide sequence ID" value="XM_447309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR35"/>
    <dbReference type="SMR" id="Q6FR35"/>
    <dbReference type="FunCoup" id="Q6FR35">
        <property type="interactions" value="907"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR35"/>
    <dbReference type="EnsemblFungi" id="CAGL0I01254g-T">
        <property type="protein sequence ID" value="CAGL0I01254g-T-p1"/>
        <property type="gene ID" value="CAGL0I01254g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889117"/>
    <dbReference type="KEGG" id="cgr:2889117"/>
    <dbReference type="CGD" id="CAL0130400">
        <property type="gene designation" value="CAGL0I01254g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I01254g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01254g"/>
    <dbReference type="eggNOG" id="KOG2017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FR35"/>
    <dbReference type="OMA" id="IPDVGMD"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070566">
        <property type="term" value="F:adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000220">
        <property type="term" value="P:regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000014">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03049">
        <property type="entry name" value="MOCS3_Uba4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028885">
        <property type="entry name" value="MOCS3/Uba4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000369224" description="Adenylyltransferase and sulfurtransferase UBA4">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="332"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate; for adenylyltransferase activity" evidence="2">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate; for sulfurtransferase activity" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03049"/>
        </source>
    </evidence>
    <sequence length="433" mass="47669" checksum="7EE22729C3006573" modified="2004-07-19" version="1">MTDQDLLAQIELLKKENAQLKEKLKSQDDEQLSLEEYSRYGRQMIVEGTGGVVGQLRLKKAKVLVVGAGGLGSPSLPYLVGAGVGTIGIVDNDIVDTSNLHRQTIHNTAKVGMLKCESAKQVLKDLNPHVNINTYPVRLGPENAFSIFADYDIVMDCTDTPLTRYLISDVAVNLGKTVVSASGLGTEGQLTILNFNNIGPCYRCFYPVSPNPYAVSSCQEGGVIGPCIGLVGTMMAVETLKIIMGVYNNENFEPFLLSYSGFPIQSLRRFKMRGRQSKCQTCGDAPVITKEAIESGIIDYNIFCGSRNYNVCAEGERLTAKEFDENYGPEFSGNNKVLLDVRPSHHFDISHFNNAVNIPLKELRDMDGDISTLQSRIPNINKNSEVVVLCRYGNDSQLATRMLKDEFGITNVKDVAGGFFKYIDDVDQSIPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRA5</accession>
    <name>Q6FRA5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein MUM2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0H10164g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRA5"/>
    <dbReference type="FunCoup" id="Q6FRA5">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRA5"/>
    <dbReference type="KEGG" id="cgr:2888722"/>
    <dbReference type="CGD" id="CAL0132012">
        <property type="gene designation" value="CAGL0H10164g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10164g"/>
    <dbReference type="eggNOG" id="ENOG502S20W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_563824_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRA5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="313"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="53360" checksum="D091D886834FEBC1" modified="2004-07-19" version="1">MSYFYNFNQGDGFANNTSMGTQDQSAFQNQNQNQVQNQSQGKAHTQFGSGQTYIASSMLNGMSGSSYSGNYEKNVNSPQDASAYANYFQPLQNAFNSSPGFQTVTQNNLATDYSYSHANSNGNNQIASSGSTDTTTTDTTAYNVSTNNDRFPKMTSDLTHMTSQQSRYPNTTSDKGVDDQLFTSRYNSMGTLTSTSTISSIPAKQDNASYLGQVNYNGIPSNRNYTASSTTHSAMLGNSFTSDAVTGYYYPTNRETNKQGLINSTKLPSRYSGSDNGQVYNNATTFDATQSSQPSNCSATVNPKEPKESSGEIDTLKYDIQVKDAQLQSLQRELTRLKSAISVAVDNTKDISSKTADKEEHITTKEIDVPNSLDIIFRKLSSALQKREKELDETKTNLESVLAAMALNPSNSSTKFGRYDPENLAHKTVVRLETLTKENQEMARMLSFGRAKEKHIALELLKKENKDLKTQIIQLKEKLGKDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRB5</accession>
    <name>Q6FRB5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAGL0H09944g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRB5"/>
    <dbReference type="FunCoup" id="Q6FRB5">
        <property type="interactions" value="670"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRB5"/>
    <dbReference type="KEGG" id="cgr:2888730"/>
    <dbReference type="eggNOG" id="KOG1197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FRB5"/>
    <dbReference type="OMA" id="VDMSYSR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="17"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="333" mass="36758" checksum="26DBF2497D43FE0F" modified="2004-07-19" version="1">MFIPTTQKVVLIDGKSDDYDVIKYQDFAVPSIGSTDVLVKNKYAGVNFIEAYFRKGYYPCELPYVLGREASGEVVQVGSEVKDFKIGDKVAYLGGSTFAQYTKKSTENHIMNLGQSCPDEDLKLYGSSLVQCLTAISFIDEAYKVMEGDYILVYAASGGVGSILCQLISQRKAHVIAVASSAEKLAMAKENGAEFLINYAEDDILEKVMQYTNGKGVHAAFDSIGKDTFETDLAALRRKGTLVSFGNASGMVPPFAINKLSPKNLKLLRPQVYGYLGTRSEWDHYCSIFKHFVQSKSLKVDISGIYPLSEYAEVAKLLERRQTTGKVTLEIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRD1</accession>
    <name>Q6FRD1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0H09526g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRD1"/>
    <dbReference type="FunCoup" id="Q6FRD1">
        <property type="interactions" value="825"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRD1"/>
    <dbReference type="KEGG" id="cgr:2888753"/>
    <dbReference type="CGD" id="CAL0130170">
        <property type="gene designation" value="CAGL0H09526g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09526g"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_2_3_1"/>
    <dbReference type="InParanoid" id="Q6FRD1"/>
    <dbReference type="OMA" id="MKEVDQV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="181"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="482"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="667"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1098"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1124"/>
            <end position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0130170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG60146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1135" mass="128960" checksum="8F9036973ED7862B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRH0</accession>
    <name>Q6FRH0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phenylalanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0H08602g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRH0"/>
    <dbReference type="FunCoup" id="Q6FRH0">
        <property type="interactions" value="804"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRH0"/>
    <dbReference type="KEGG" id="cgr:2888734"/>
    <dbReference type="CGD" id="CAL0131614">
        <property type="gene designation" value="CAGL0H08602g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08602g"/>
    <dbReference type="eggNOG" id="KOG2783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022696_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FRH0"/>
    <dbReference type="OMA" id="PISHYPQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070156">
        <property type="term" value="P:mitochondrial phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000053">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00469">
        <property type="entry name" value="pheS_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="156"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="16">
        <location>
            <begin position="382"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0131614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG60107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="479" mass="55795" checksum="FB760A7EFE6EF2BF" modified="2004-07-19" version="1">MGSNIVVRLTPLRVVRNAIHKHIRLYSSIRQTVEINGKTYDTDEEMTNITPSIIDLTDRSLHLKPNHPIGILRKLIEGKLNDGKKAYTAYDEFKPVVSVFENFDSLGFPKDHPGRSKSDTYYINKDTLLRTHTSAHELECFKNIPKYNNDGFLITADVYRRDEIDKTHYPAFHQMEGARVWNRSIKSDGTYDISESAPHIKKLKTDIRELEDILRNEKTNMIVEDNTAREVNPKQEYMTDLEVDLVSQHLKRSIEIVVSEVFHKKIESMKALKGANDPSIPKELKVRWITAYFPWTAPSWEIEVWWEGDWLELCGCGLVQQQVLINSGNKPDSTIAWAFGLGLDRIAMLLFEIPDIRLLWTKDERFHNQFKEGKITTFTSYSKYPGSYRDIAFWLPEKLKNEVQLQENDLMEIVRNIAGDLVESVKLIDDFTHPKSKKRSLCYRINYQSMDRNLTNAEVNKLQSKVEEELIRLFQVELR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRJ6</accession>
    <name>RT106_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Histone chaperone RTT106</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RTT106</name>
        <name type="ordered locus">CAGL0H08041g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with histones H3 and H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RTT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447148.1">
        <property type="nucleotide sequence ID" value="XM_447148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRJ6"/>
    <dbReference type="SMR" id="Q6FRJ6"/>
    <dbReference type="FunCoup" id="Q6FRJ6">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRJ6"/>
    <dbReference type="EnsemblFungi" id="CAGL0H08041g-T">
        <property type="protein sequence ID" value="CAGL0H08041g-T-p1"/>
        <property type="gene ID" value="CAGL0H08041g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888512"/>
    <dbReference type="KEGG" id="cgr:2888512"/>
    <dbReference type="CGD" id="CAL0131910">
        <property type="gene designation" value="RTT106"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H08041g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08041g"/>
    <dbReference type="eggNOG" id="ENOG502R9PE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040939_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FRJ6"/>
    <dbReference type="OMA" id="TRLTFNV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13303">
        <property type="entry name" value="PH1-like_Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11604">
        <property type="entry name" value="RTT106_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.70">
        <property type="entry name" value="RTT106-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040993">
        <property type="entry name" value="Rtt106_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044891">
        <property type="entry name" value="Rtt106_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040770">
        <property type="entry name" value="Rtt106_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18469">
        <property type="entry name" value="PH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18215">
        <property type="entry name" value="Rtt106_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000320488" description="Histone chaperone RTT106">
        <location>
            <begin position="1"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="453" mass="51392" checksum="0E4A9C93A4E18BBE" modified="2004-07-19" version="1">MSSFDFLNELPKELQNKIRNITRALPSSLEVFQELYNYGLSHSDNIEKKRKVTSNGVIDEQNIIFSLKNVSVLSPIRKKLDLVLHLSSIDHKPQLSLVKNGVSEFSISNLKDNVKMGTFLPVPEKPNLLYLFVQLKKVNDKDQDPILLTMNKENVLTEFKSMGLIGQEVDDFNKCTEYIRKQAILTGFKIANPFNPSVEQPVPSFHVECHRGTKEGTLYFLPEIIIFGFKKPILVFESSNIESISYSSITRLTFNVTLIKKVDDGYGTKFEFSMIDQTEYSKIDDYVKLKQVKDESMSEELKAKTANKNKQQNNTSDQPSALQEATKQMETEGNINEIPFDSEDDEEADGNFEDNSDLSDGSEVEEEDNEEENEEDEEADGGDYAEEDFEEDEIIQEQANPAVNQLISKTTPINKNSSNAGLFDFPIETPSFDIPIELEDNEDDEEGSGVEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRN0</accession>
    <name>Q6FRN0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA repair protein RAD34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0H07293g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FRN0">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRN0"/>
    <dbReference type="KEGG" id="cgr:2888568"/>
    <dbReference type="CGD" id="CAL0132048">
        <property type="gene designation" value="CAGL0H07293g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07293g"/>
    <dbReference type="eggNOG" id="KOG2179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028212_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRN0"/>
    <dbReference type="OMA" id="QWKFLGR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="413"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="470"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="10">
        <location>
            <begin position="548"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0132048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="668" mass="79141" checksum="90249117289987EB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRN3</accession>
    <name>Q6FRN3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0H07227g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRN3"/>
    <dbReference type="FunCoup" id="Q6FRN3">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRN3"/>
    <dbReference type="KEGG" id="cgr:2888524"/>
    <dbReference type="CGD" id="CAL0131806">
        <property type="gene designation" value="CAGL0H07227g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07227g"/>
    <dbReference type="eggNOG" id="KOG4300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665906_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRN3"/>
    <dbReference type="OMA" id="TWGCRWN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000371">
        <property type="entry name" value="Methyltransferase OMS1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="12">
        <location>
            <begin position="228"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0131806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG60044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="452" mass="52473" checksum="DB770C80A8FEC633" modified="2004-07-19" version="1">MLLMRCVAQTRNRFPVVRPILQVHYSARYKSDANSNTKTYIPQPTAKVRRPKTKEEIAKEKHEKALQSPYRLVRWAAIASSEKFNKSMTKYMVGIYAIFLIYGVYFSKKLFQKEKELEKLEGKAKTSGINEYESLRIKELRGKLRRRDELKLEQYQQMIDKGITDFDGITLENNDQNRLNESIVPAHDTTEFYDHKAEEYDKAINSEERAILMGRKRKWLMKHCEGDVLEVACGTGRNIKYLDIERVNSLIFLDSSENMLEIANKKFRDRFPTYKKVAFVKGRAEDLLDLAGDDPDKKEQKKFDTIIEAFGLCSHEDPVKALKNFQELLKPGGRIVLLEHGRGSVGLINKILDKRAKRRLETWGCRWNLDIGEILDDSGLDVVEEYTSHLGTTWCVVAKKKSDVRKKKEISFIEKYFRSGLREKIQHMNEENNRTTSNVNSNNAEIPSNTSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRR4</accession>
    <name>ATG32_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATG32</name>
        <name type="ordered locus">CAGL0H06545g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitophagy-specific receptor that recruits the autophagic machinery to mitochondria and regulates selective degradation of mitochondria. Mitophagy contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Recruits ATG11 to the surface of mitochondria. Also promotes autophagy-dependent peroxisome degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Is recruited to the preautophagosomal structure during mitophagy and imported into the vacuole along with mitochondria during starvation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATG32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447080.1">
        <property type="nucleotide sequence ID" value="XM_447080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRR4"/>
    <dbReference type="SMR" id="Q6FRR4"/>
    <dbReference type="FunCoup" id="Q6FRR4">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRR4"/>
    <dbReference type="EnsemblFungi" id="CAGL0H06545g-T">
        <property type="protein sequence ID" value="CAGL0H06545g-T-p1"/>
        <property type="gene ID" value="CAGL0H06545g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888646"/>
    <dbReference type="KEGG" id="cgr:2888646"/>
    <dbReference type="CGD" id="CAL0130627">
        <property type="gene designation" value="CAGL0H06545g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06545g"/>
    <dbReference type="eggNOG" id="ENOG502QY5V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039418_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRR4"/>
    <dbReference type="OMA" id="IPICQPG"/>
    <dbReference type="PHI-base" id="PHI:6582"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19929">
        <property type="entry name" value="psREC_Atg32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000399757" description="Autophagy-related protein 32">
        <location>
            <begin position="1"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="492" mass="55053" checksum="84D7D162CAFB2C98" modified="2004-07-19" version="1">MLRFQRGTVKESSSAKLASTSRNGPESSILDPHHSVMELLQRQMEGSEVPSESGVLGESWQQIRESDVGDGGDSNFDQQSNTSAILSSSSEASEDEDLDIQQQLLGGQQEYKNFHMTAEEQLQEQAQGQGFGRPSLLKGTQSRLSEQDSNRSGSVRTIVDKGSCSSSLDEHELNSIFTSDSMSLTKSTGSSSTSFVMPKLSLTYKPSQAKKLLVVGRLSKRFHQDIPREYRQYFHISQSSDPSEFQNYIGIVIVFQELKEFVAMLNRIVQYTDKKPIIPICQPGQRIRVKNILKSFLKNDAITLWYPPVTIANEKSMEKLFKHTVKLVNKLENEEDVLSLSTSDKSLSDETSGYRKNNRRKKHGGKPSTNYSKWITWGISLTIGVSIGYYATYMITTTLLYGKAESHHANEAKGFSITNGNSGSSSISHSTEYYESTISQKGLLRNTIVFIKRTIHNLNGKVGTFFASITQVIKQTPVREDNQFYTLGYMLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2025-06-18" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRV2</accession>
    <name>GSHR_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Glutathione reductase</fullName>
            <shortName>GR</shortName>
            <shortName>GRase</shortName>
            <ecNumber>1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">GLR1</name>
        <name type="ordered locus">CAGL0H05665g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="3">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447042.1">
        <property type="nucleotide sequence ID" value="XM_447042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRV2"/>
    <dbReference type="SMR" id="Q6FRV2"/>
    <dbReference type="FunCoup" id="Q6FRV2">
        <property type="interactions" value="1160"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRV2"/>
    <dbReference type="EnsemblFungi" id="CAGL0H05665g-T">
        <property type="protein sequence ID" value="CAGL0H05665g-T-p1"/>
        <property type="gene ID" value="CAGL0H05665g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888553"/>
    <dbReference type="KEGG" id="cgr:2888553"/>
    <dbReference type="CGD" id="CAL0131774">
        <property type="gene designation" value="GLR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H05665g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05665g"/>
    <dbReference type="eggNOG" id="KOG0405">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FRV2"/>
    <dbReference type="OMA" id="MSKHYDY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000671">
        <property type="entry name" value="Thioredoxin reductase 2, tandem duplicate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000067966" description="Glutathione reductase">
        <location>
            <begin position="1"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>glutathione</name>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="54"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P06715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P41921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="476" mass="52499" checksum="BA4793D0F077D14D" modified="2004-07-19" version="1">MIVKRLFRTMAPVAKHFDYLVIGGGSGGVASSRRAASYGAKTLLIEGKALGGTCVNVGCVPKKVMWYASDLATRLTHAHEYGLAQNVPLSKESITFNWPEFKKKRDAYIHRLNGIYENNLKKEGVEVVFGWAKFNKDGNVEVTKHDNTTEVYSADRILVATGGKPVYPEKVPGFELGTDSDGFFRLEEQPKKVVVVGAGYIGIELAGVFHGLGSDSHLVIRGKTVLRKFDEIIQNTVTDYYVEEGINVHKETNVDKVEKDEKTGKLSVHLTNGQVLEDVDELIWTMGRRSLLGIGLENVGVKLNDKEQIITDEYQNTNVPNIYSLGDVSGRVELTPVAIAAGRKLSNRLFGPEQYRNDKLDYTNVPSVVFSHPEAGSIGLTEDEAIKQYGKDNIKVYTSKFTAMYYAMLEHKSPTRYKIICEGPNEKVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAEELVTMR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2025-06-18" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRY2</accession>
    <name>MPG12_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mannose-1-phosphate guanyltransferase 2</fullName>
            <ecNumber>2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>ATP-mannose-1-phosphate guanylyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>GDP-mannose pyrophosphorylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MPG1</name>
        <name type="ordered locus">CAGL0H04983g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRY2"/>
    <dbReference type="SMR" id="Q6FRY2"/>
    <dbReference type="STRING" id="284593.Q6FRY2"/>
    <dbReference type="EnsemblFungi" id="CAGL0H04983g-T">
        <property type="protein sequence ID" value="CAGL0H04983g-T-p1"/>
        <property type="gene ID" value="CAGL0H04983g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888449"/>
    <dbReference type="CGD" id="CAL0129988">
        <property type="gene designation" value="PSA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H04983g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04983g"/>
    <dbReference type="eggNOG" id="KOG1322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRY2"/>
    <dbReference type="OMA" id="GRPFLEW"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000248401" description="Mannose-1-phosphate guanyltransferase 2">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="361" mass="39611" checksum="FCF021E334A6872B" modified="2004-07-19" version="1">MKGLILVGGYGTRLRPLTLSVPKPLVEFCNRPMILHQIEALAEAGVTDIVLAVNYRPEVMVDTLKKYEKEYGVNITFSVETEPLGTAGPLKLAEKILKKDNSPFFVLNSDVICEYPFKELAEFHKSHGGKGTIVATKVDEPSKYGVIVHDLGTPNLIDRFVEKPKEFVGNRINAGLYILNPEVIDLIEMKPTSIETETFPKLVNEKSLYTFDLEGFWMDVGQPKDFLAGTGLYLQSLSRRHPEKLSTGSNIVSNAIIDPTAKISPDAKIGPDVVIGPNCVIGSGVRIVRSVLLKNCVVKENSLIKDTIVGWDSTIGRWCRLEGCAVLGHDVAVKDEVYVNGAKVLPHKSISANVPSEAIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS73</accession>
    <name>Q6FS73_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">U3 small nucleolar RNA-associated protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0H02937g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS73"/>
    <dbReference type="FunCoup" id="Q6FS73">
        <property type="interactions" value="1153"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS73"/>
    <dbReference type="KEGG" id="cgr:2888885"/>
    <dbReference type="CGD" id="CAL0130575">
        <property type="gene designation" value="CAGL0H02937g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02937g"/>
    <dbReference type="eggNOG" id="KOG2055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011055_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FS73"/>
    <dbReference type="OMA" id="DLNRATY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000292">
        <property type="term" value="P:RNA fragment catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000660">
        <property type="entry name" value="U3 snoRNP protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="580"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0130575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="67692" checksum="7B3880D9ED9FDA97" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS89</accession>
    <name>Q6FS89_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0H02519g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446905.1">
        <property type="nucleotide sequence ID" value="XM_446905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS89"/>
    <dbReference type="FunCoup" id="Q6FS89">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS89"/>
    <dbReference type="KEGG" id="cgr:2888657"/>
    <dbReference type="CGD" id="CAL0131504">
        <property type="gene designation" value="CAGL0H02519g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02519g"/>
    <dbReference type="eggNOG" id="KOG4510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032828_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FS89"/>
    <dbReference type="OMA" id="WYSMMYI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="81"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="6">
        <location>
            <begin position="220"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0131504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="384" mass="42486" checksum="9D03A7447654855E" modified="2004-07-19" version="1">MADASKTIVKESDFEINDGNDASSAGSATEAGMVARLNQEYLKPNVGLIFLIVSQLFNSLMVVSTKVLELDREGLEPDEPSIQPLQILLVRMIITYIGTLIYMKINSSSIEYVPFGNPAVRPWLIMRGAMGFFGVFGMYFSLMYLTISDAVLITFLAPSVTIILAWIILRESFSKAEGIGSFVSLAGVVLIVRPTFLFGNPTTSDGDIDETTDPHKRLIATLVALWGVVGISSVWIIIRYIGKRAHAIINVSYFSLITGLIALFGILFVPSVHFQTPRTLKQWLLFANLGICGFCHQLLLTIGIQKERAGRGTLMSYTNLIYAVFWDVLLFGHWPSFWSICGMILITGSTLYIVKMKANDAKPQAVNNNSIQTEFDLEDLSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSE2</accession>
    <name>Q6FSE2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent helicase HRQ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0H01243g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAG59785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSE2"/>
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        <property type="gene designation" value="CAGL0H01243g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01243g"/>
    <dbReference type="eggNOG" id="KOG4150">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000809_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FSE2"/>
    <dbReference type="OMA" id="GAVHLHQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042275">
        <property type="term" value="P:error-free postreplication DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032202">
        <property type="term" value="P:telomere assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17923">
        <property type="entry name" value="DEXHc_Hrq1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18797">
        <property type="entry name" value="SF2_C_Hrq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001137">
        <property type="entry name" value="DEAD/DEAH box helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055227">
        <property type="entry name" value="HRQ1_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018973">
        <property type="entry name" value="MZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09369">
        <property type="entry name" value="MZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22982">
        <property type="entry name" value="WHD_HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="304"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="527"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1094" mass="125899" checksum="BC75B6398394131E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSI3</accession>
    <name>Q6FSI3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0H00308g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSI3"/>
    <dbReference type="FunCoup" id="Q6FSI3">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSI3"/>
    <dbReference type="KEGG" id="cgr:2888471"/>
    <dbReference type="CGD" id="CAL0131570">
        <property type="gene designation" value="CAGL0H00308g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00308g"/>
    <dbReference type="eggNOG" id="ENOG502QWCQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051401_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSI3"/>
    <dbReference type="OMA" id="WEQPHRL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990468">
        <property type="term" value="C:NuA3b histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05840">
        <property type="entry name" value="PWWP_ScIOC4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035503">
        <property type="entry name" value="IOC4-like_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="320" mass="37104" checksum="57CC0BB7D04F0309" modified="2004-07-19" version="1">MTTSNNLKTGDLVLCKVGSFPPWPAVVFPQRLLRKDVIKKKRNNCIAVCFLNDPTYYWEQPHKLKRLEKNIITEYLSKEHKSQSQADLVEAYSQADQFGDLRSFVVERFSSEDRIEDLEKDEELYGKLKSGEDPHITDPDTNSRKRKSSSKDDGKVSSSKKIKASKDITSMAKSSDNQLIIDNSVDKEKKKSNKLDRSRREEISLLLRRRIQRNLIQRDTPPTDVELQESHKLLSKIKENLDDQPPFFDLDTLRKSKLHKLLKVIVNNSDLKEFHDICKSILLHWSDIIATLKAEKLNHLKQAYQSETTDRDDPSLKEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSJ6</accession>
    <name>Q6FSJ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0G10065g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSJ6"/>
    <dbReference type="FunCoup" id="Q6FSJ6">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSJ6"/>
    <dbReference type="KEGG" id="cgr:2888159"/>
    <dbReference type="CGD" id="CAL0129660">
        <property type="gene designation" value="CAGL0G10065g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G10065g"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_9_2_1"/>
    <dbReference type="InParanoid" id="Q6FSJ6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032038">
        <property type="term" value="F:myosin II heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000178">
        <property type="entry name" value="Calmodulin-2 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="15"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0129660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="159" mass="18210" checksum="ED6D2299909147CE" modified="2004-07-19" version="1">MENSNSLHFDRLTQRQINKLKDAFQLIDEDGDGNIGRSDMVKMLASLGQKVTTDDVGKMFKELRDENDAYISFPEFLALMSESICEFPQEDELKECFGIISQNKDLDLPTDKLIKLLEEAGFKNPEEEFKRILATFSANQQLDGSRNFKSNQFIDSLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSK7</accession>
    <name>Q6FSK7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0G09823g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSK7"/>
    <dbReference type="FunCoup" id="Q6FSK7">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSK7"/>
    <dbReference type="KEGG" id="cgr:2888292"/>
    <dbReference type="CGD" id="CAL0130640">
        <property type="gene designation" value="CAGL0G09823g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09823g"/>
    <dbReference type="eggNOG" id="KOG0366">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FSK7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170069">
        <property type="term" value="C:geranylgeranyltransferase-III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="12">
        <location>
            <begin position="4"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0130640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="320" mass="36332" checksum="DBB99606B15B44CA" modified="2004-07-19" version="1">MVELLKQKHIEYIESLDKRKEDYEYWLSEHLRLNGVYWGLTALCILDSKKSFDKDEVVKFVLSCWDARTGGFAPFPRHDAHLLTTLSGLQILVTYDSLDILTSEQKDKCYEFIVSNQLPDGSFQGDRFGEVDSRFVYTALSSLSILGRLSEEIVEPAVQFIVRCYNFDGGFCMSPGAESHAAQAFCCLGALAIVGRLNVFTDSQIEEIGWWLCERQIPEGGLNGRPSKLPDVCYSWWVLSSLAIIGKLDWIDYDKLREFILDSQDQIKGGISDRPDNEVDVYHTLFGLAGLSLMGFDSLIEINPVYCMPQTVVNKIKNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSL7</accession>
    <name>Q6FSL7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G09603g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446777.1">
        <property type="nucleotide sequence ID" value="XM_446777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSL7"/>
    <dbReference type="KEGG" id="cgr:2888272"/>
    <dbReference type="CGD" id="CAL0129176">
        <property type="gene designation" value="CAGL0G09603g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09603g"/>
    <dbReference type="HOGENOM" id="CLU_1937882_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSL7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="130" mass="14568" checksum="47142C1FB266CAF4" modified="2004-07-19" version="1">MLCGERHEYNTSIFDSLRELVSNGLNFLLDESLVEETLLQQQDDLGTLIIPPMDDGPDNLFFVGLIWFIIGLLCALVLATITIILVSRSSSDQSVRNKACEDLEALDLDSSDDDELIEQEKLVYELMQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSS6</accession>
    <name>Q6FSS6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0G08173g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSS6"/>
    <dbReference type="FunCoup" id="Q6FSS6">
        <property type="interactions" value="1238"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSS6"/>
    <dbReference type="KEGG" id="cgr:2888200"/>
    <dbReference type="CGD" id="CAL0130829">
        <property type="gene designation" value="CAGL0G08173g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08173g"/>
    <dbReference type="eggNOG" id="KOG0004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FSS6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002109">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000008">
        <property type="entry name" value="Ubiquitin-40S ribosomal protein S27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0130829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="152" mass="17135" checksum="DC05030C2C86B389" modified="2004-07-19" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGGKKRKKKVYTTPKKIKHKHKKVKLAVLSYYKVDGEGTVTKLRKECSNPTCGAGVFLADHKTRLYCGKCHSVYKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FST1</accession>
    <name>Q6FST1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0G08063g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FST1"/>
    <dbReference type="FunCoup" id="Q6FST1">
        <property type="interactions" value="1003"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FST1"/>
    <dbReference type="KEGG" id="cgr:2888239"/>
    <dbReference type="CGD" id="CAL0130528">
        <property type="gene designation" value="CAGL0G08063g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08063g"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_2_1"/>
    <dbReference type="InParanoid" id="Q6FST1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031371">
        <property type="term" value="C:ubiquitin conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010994">
        <property type="term" value="P:free ubiquitin chain polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044395">
        <property type="term" value="P:protein targeting to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000020">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0130528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="149" mass="16973" checksum="9B19FFAC32D5E643" modified="2004-07-19" version="1">MASLPKRIIKETERLVSDPVPGITAEPHEDNLRYFDVTIEGPSQSPYEKGIFKLELYLPEDYPMEAPKVRFLTKIYHPNIDRLGRICLDVLKTNWSPALQIRTVLLSIQALLASPNPNDPLANDVAEDWIKDEAKAKQTAKEWTAQYAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSU1</accession>
    <name>PESC_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pescadillo homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleolar protein 7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NOP7</name>
        <name type="ordered locus">CAGL0G07843g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pescadillo family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446703.1">
        <property type="nucleotide sequence ID" value="XM_446703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSU1"/>
    <dbReference type="SMR" id="Q6FSU1"/>
    <dbReference type="FunCoup" id="Q6FSU1">
        <property type="interactions" value="1467"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSU1"/>
    <dbReference type="EnsemblFungi" id="CAGL0G07843g-T">
        <property type="protein sequence ID" value="CAGL0G07843g-T-p1"/>
        <property type="gene ID" value="CAGL0G07843g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888380"/>
    <dbReference type="KEGG" id="cgr:2888380"/>
    <dbReference type="CGD" id="CAL0137773">
        <property type="gene designation" value="CAGL0G07843g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_G07843g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07843g"/>
    <dbReference type="eggNOG" id="KOG2481">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019619_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FSU1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000067">
        <property type="entry name" value="Pescadillo homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000370485" description="Pescadillo homolog">
        <location>
            <begin position="1"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="345"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="515"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="557"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="598" mass="68491" checksum="A56D1B30F2E2C7A0" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT29</accession>
    <name>Q6FT29_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0G05830g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT29"/>
    <dbReference type="STRING" id="284593.Q6FT29"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888165"/>
    <dbReference type="CGD" id="CAL0137643">
        <property type="gene designation" value="CAGL0G05830g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05830g"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_337700_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT29"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22265">
        <property type="entry name" value="UDM1_RNF168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="600"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="704"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="794"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0137643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="843" mass="93324" checksum="C86C4747728B859F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-15" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT39</accession>
    <name>DTD_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName>DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DTD1</name>
        <name type="ordered locus">CAGL0G05610g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446605.1">
        <property type="nucleotide sequence ID" value="XM_446605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT39"/>
    <dbReference type="SMR" id="Q6FT39"/>
    <dbReference type="FunCoup" id="Q6FT39">
        <property type="interactions" value="1672"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT39"/>
    <dbReference type="EnsemblFungi" id="CAGL0G05610g-T">
        <property type="protein sequence ID" value="CAGL0G05610g-T-p1"/>
        <property type="gene ID" value="CAGL0G05610g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888282"/>
    <dbReference type="KEGG" id="cgr:2888282"/>
    <dbReference type="CGD" id="CAL0130653">
        <property type="gene designation" value="CAGL0G05610g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05610g"/>
    <dbReference type="eggNOG" id="KOG3323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_0_4_1"/>
    <dbReference type="InParanoid" id="Q6FT39"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097358">
        <property type="term" value="F:D-leucyl-tRNA(Leu) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900832">
        <property type="term" value="P:D-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900829">
        <property type="term" value="P:D-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000164630" description="D-aminoacyl-tRNA deacylase">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q8IIS0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="149" mass="16590" checksum="909859E0BF2DED8D" modified="2004-07-19" version="1">MRIVIQKVSQAMVKVDNEIVSQIAKGYMLLVGISTEDTIADAQKLSNKVLNLRLFETGDQFWKHSIQDVQGEILSVSQFTLMARTKKGNKPDFHKAQKGEHAQELYNQFLDLLKTTLGADKVKDGQFGAMMSCSLTNEGPVTIILDSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT58</accession>
    <name>Q6FT58_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G05203g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT58"/>
    <dbReference type="FunCoup" id="Q6FT58">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT58"/>
    <dbReference type="KEGG" id="cgr:2888160"/>
    <dbReference type="CGD" id="CAL0137631">
        <property type="gene designation" value="CAGL0G05203g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05203g"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047845_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FT58"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000084">
        <property type="entry name" value="Tyrosine phospatase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF14">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE OCA6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="217" mass="25200" checksum="46359084116CD462" modified="2004-07-19" version="1">MSLITPLQFSTVQPNLYRGSYPRELNIPFLRSLRLKYVVSLTPHSLAEDPVMSRFCTEDGIEMIHILCQDEKKSKDKTKPKVKRKKKTVPIEYTVVEECARFLVDKQHYPCYMHCTNGELITSLVVACLRKLSYWSTVSILNEFLAYNSSINIHERNFIENFSSEIQIENVDLRNKVPWMAIQVVKKRDKKDIDDGKHDDSPSPMPKPLPKLTFHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTE8</accession>
    <name>Q6FTE8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWF19-like protein DRN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0G03069g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTE8"/>
    <dbReference type="FunCoup" id="Q6FTE8">
        <property type="interactions" value="1207"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTE8"/>
    <dbReference type="KEGG" id="cgr:2888363"/>
    <dbReference type="CGD" id="CAL0137593">
        <property type="gene designation" value="CAGL0G03069g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03069g"/>
    <dbReference type="eggNOG" id="KOG2476">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019955_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTE8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="241"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="394"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0137593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55682" checksum="DCDBEB89F0C09ADE" modified="2004-07-19" version="1">MKIMVANPGLENTKEALDKIQIANEKNGPFETVFLLGQNKEDTSYDLKDTNTILVTNQLKNGRTTRKSSVIILHGFGIMKLASGLVVGYITLSKNSLQQEKKSILEYFKASKEFIDVLVTNIGSKAVASHLQYKANGNSIIDEVMKHCKPQYHLTYDGDRGYHDMKPFCWGETSSDSQITRYYNLPSYSPITKSKWIVAFSIEPGKDFNEINDYKNELGTNPYLLKPALKRDRSGIEQNAHTKKTKIDSTTCHFCFSNPNVEDQMIVAIAKHSYLTLAKGPLTVPKGDMSFSGHALITPINHVAKIDKSLDNELSKEIELFESRVAKMNYKLFDCSTVVFEIQSDKAIHFHKQVIPVPKYLITKFERALDRQVHINSERGNCKLEFEKFDGLDNEEYRKIVGRKDTNYLQFTIYETDTSKATIYISSFDITERLDLQYGRRTLAFVLNLPKRVQWNSPICQQSKEQELKEAQLYQKSFKNFDFTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTF0</accession>
    <name>Q6FTF0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nop domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0G03025g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTF0"/>
    <dbReference type="FunCoup" id="Q6FTF0">
        <property type="interactions" value="1291"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTF0"/>
    <dbReference type="KEGG" id="cgr:2888350"/>
    <dbReference type="CGD" id="CAL0130612">
        <property type="gene designation" value="CAGL0G03025g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03025g"/>
    <dbReference type="eggNOG" id="KOG2574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026337_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FTF0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="236"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0130612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="479" mass="54159" checksum="34365F6FFBFEE18D" modified="2004-07-19" version="1">MSDIESEADLLADLDNDFEDNEISDGGDELEDKSIEDLDVTEAYDFKNQHYEANDEDQIIVDNSAKTLKDLVKYLGAKSNVDHKGLQTEIVNLETIKHLIAISSNEPEIIKTLNEIQQYCKVISEKCYFELTEIYEDKFSELKSILRLPHQYAQCISLLEQGLELEQVVLRFEELCSTSRELIMVLNMSLRADYKGNYKLTDTNKKSLHKLTSIIFEAHDIIRFVSVEIANRIGEIAPNLCALLGTNTASLLVSHTGGLLQLSKIPSCNIANIGKKNTKDHNILNFSNPGGYIFQNELVQNQPIENHKQMMRMLSSKVSLAARVDAGLKTGDKNNKLGKQWRVEIEEKIKKIRAPPNISDVKALPIPEDKPKKKRAGRKFRKYKEQFKLSGTRQLQNRMVFGKQEATIYDTFGDEVGLGMTSQRKNGLAISTTGSSFGVKKPQYIQKKLKDSKRSTQEYIDALADRIDEHANLIKPNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTI4</accession>
    <name>Q6FTI4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0G02255g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTI4"/>
    <dbReference type="FunCoup" id="Q6FTI4">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTI4"/>
    <dbReference type="KEGG" id="cgr:2888110"/>
    <dbReference type="CGD" id="CAL0137561">
        <property type="gene designation" value="CAGL0G02255g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02255g"/>
    <dbReference type="eggNOG" id="KOG0458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FTI4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="159"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0137561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="594" mass="67043" checksum="1660E11BC89E72DB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTN3</accession>
    <name>Q6FTN3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin-95</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Karyopherin-95</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0G01144g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTN3"/>
    <dbReference type="FunCoup" id="Q6FTN3">
        <property type="interactions" value="1568"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTN3"/>
    <dbReference type="KEGG" id="cgr:2888385"/>
    <dbReference type="CGD" id="CAL0137695">
        <property type="gene designation" value="CAGL0G01144g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01144g"/>
    <dbReference type="eggNOG" id="KOG1241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008296_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTN3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097718">
        <property type="term" value="F:disordered domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061676">
        <property type="term" value="F:importin-alpha family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
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        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
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        <property type="term" value="P:protein targeting to membrane"/>
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        <property type="term" value="P:regulation of nucleocytoplasmic transport"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:regulation of protein desumoylation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
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    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
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    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="12">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="412"/>
            <end position="450"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00079884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0137695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="861" mass="95059" checksum="74B9E54D783513C5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTQ0</accession>
    <name>Q6FTQ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RFA1</name>
        <name evidence="15 16" type="ordered locus">CAGL0G00726g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446394.1">
        <property type="nucleotide sequence ID" value="XM_446394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTQ0"/>
    <dbReference type="FunCoup" id="Q6FTQ0">
        <property type="interactions" value="1259"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTQ0"/>
    <dbReference type="GeneID" id="2888281"/>
    <dbReference type="KEGG" id="cgr:2888281"/>
    <dbReference type="CGD" id="CAL0130644">
        <property type="gene designation" value="RFA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00726g"/>
    <dbReference type="eggNOG" id="KOG0851">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012393_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FTQ0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030491">
        <property type="term" value="P:heteroduplex formation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="203"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="311"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="472"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0130644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG59321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="627" mass="70574" checksum="3B0C25221BA2CFBF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTU1</accession>
    <name>Q6FTU1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signaling mucin MSB2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0F08833g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTU1"/>
    <dbReference type="STRING" id="284593.Q6FTU1"/>
    <dbReference type="KEGG" id="cgr:2887570"/>
    <dbReference type="CGD" id="CAL0131402">
        <property type="gene designation" value="CAGL0F08833g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08833g"/>
    <dbReference type="eggNOG" id="ENOG502QW7T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_313078_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTU1"/>
    <dbReference type="OMA" id="SGRNQMI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000282">
        <property type="term" value="P:cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012181163" description="Signaling mucin MSB2" evidence="3">
        <location>
            <begin position="16"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0131402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="936" mass="98344" checksum="31DFD10A90004A18" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTV4</accession>
    <name>Q6FTV4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EFB1</name>
        <name evidence="8 9" type="ordered locus">CAGL0F08547g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446340.1">
        <property type="nucleotide sequence ID" value="XM_446340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTV4"/>
    <dbReference type="FunCoup" id="Q6FTV4">
        <property type="interactions" value="823"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTV4"/>
    <dbReference type="GeneID" id="2887849"/>
    <dbReference type="KEGG" id="cgr:2887849"/>
    <dbReference type="CGD" id="CAL0129370">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08547g"/>
    <dbReference type="eggNOG" id="KOG1668">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050172_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FTV4"/>
    <dbReference type="OMA" id="YRWYKHI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032232">
        <property type="term" value="P:negative regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="7">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="121"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22917" checksum="968F19B8C07E87AC" modified="2004-07-19" version="1">MAFTDFSKIDTVKELNTVLGEKSYVEGTSATQADVEAYKAFRTAYPNFSRWFNHIAAKADEFDSFPAASGASAAAEEEDDDDVDLFGSDDEVDEEAEKLKAQRLEEYNKRKAAKGPKPAAKSIVTLDVKPWDDETDLEEMLANTKAVQMDGLNWGAHQFIPIGFGIKKLQINCVVEDAKVSLDDLQQAIEDDEDHVQSTDIAAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTV6</accession>
    <name>Q6FTV6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0F08503g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTV6"/>
    <dbReference type="FunCoup" id="Q6FTV6">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTV6"/>
    <dbReference type="KEGG" id="cgr:2887571"/>
    <dbReference type="CGD" id="CAL0131396">
        <property type="gene designation" value="CAGL0F08503g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08503g"/>
    <dbReference type="eggNOG" id="KOG2698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049768_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FTV6"/>
    <dbReference type="OMA" id="CEHMCMS"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="13">
        <location>
            <begin position="64"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0131396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG59262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="245" mass="27627" checksum="18406A2716FF5AD5" modified="2004-07-19" version="1">MQQALNHRLSSMERTGTPLNTRPASPYTSIPTVASDGLSWPSKGARTRAHETEEEEKQRTGRIADAVKVILEELGEDVTREGLLDTPQRYAKAMLFFTKGYQTNIMDDVINNAVFEEDHDEMVIVRDIEIYSLCEHHLVPFFGKVHIGYIPNKKVIGLSKLARLAEMYARRLQVQERLTKQIAMALSEILKPLGVAVVIEASHMCMVSRGVQKTGSSTMTSCMMGCFRSHKTREEFLTLLGRRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTW8</accession>
    <name>Q6FTW8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0F08217g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTW8"/>
    <dbReference type="FunCoup" id="Q6FTW8">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTW8"/>
    <dbReference type="KEGG" id="cgr:2887802"/>
    <dbReference type="CGD" id="CAL0131176">
        <property type="gene designation" value="CAGL0F08217g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08217g"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018630_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTW8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="139"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="276"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="440"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="542"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0131176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="678" mass="76413" checksum="A241B115FE5085B2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTZ2</accession>
    <name>Q6FTZ2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LNS2/PITP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0F07689g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTZ2"/>
    <dbReference type="FunCoup" id="Q6FTZ2">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTZ2"/>
    <dbReference type="KEGG" id="cgr:2887912"/>
    <dbReference type="CGD" id="CAL0129579">
        <property type="gene designation" value="CAGL0F07689g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07689g"/>
    <dbReference type="eggNOG" id="KOG2116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002546_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FTZ2"/>
    <dbReference type="OMA" id="QDYSMKL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006651">
        <property type="term" value="P:diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006276">
        <property type="term" value="P:plasmid maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="366"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="606"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="660"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="772"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="789"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="803"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0129579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="819" mass="90385" checksum="DCEDEAFEA714452D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU47</accession>
    <name>Q6FU47_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0F06435g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU47"/>
    <dbReference type="FunCoup" id="Q6FU47">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU47"/>
    <dbReference type="KEGG" id="cgr:2887773"/>
    <dbReference type="CGD" id="CAL0130990">
        <property type="gene designation" value="CAGL0F06435g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06435g"/>
    <dbReference type="eggNOG" id="ENOG502SC4F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083361_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FU47"/>
    <dbReference type="OMA" id="VYYFVYK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="8"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0130990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="126" mass="14795" checksum="EABD32340FE90257" modified="2004-07-19" version="1">MSNLTERVRDNLLHFHLWTEVEEVPKQLNWKDDRIINILVGRPPHKLSNDDDEEQEGDCKRAKKEYILPVEMSMYKEGYLTLELLDKIFDDLCAASTQRLLLGIVNDDGTVLYYFAHKGIYKPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUI3</accession>
    <name>Q6FUI3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">IRE1</name>
        <name evidence="23 24" type="ordered locus">CAGL0F03245g</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446111.1">
        <property type="nucleotide sequence ID" value="XM_446111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUI3"/>
    <dbReference type="FunCoup" id="Q6FUI3">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUI3"/>
    <dbReference type="GeneID" id="2887705"/>
    <dbReference type="KEGG" id="cgr:2887705"/>
    <dbReference type="CGD" id="CAL0131040">
        <property type="gene designation" value="IRE1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03245g"/>
    <dbReference type="eggNOG" id="KOG1027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004875_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FUI3"/>
    <dbReference type="OMA" id="IRYYCSE"/>
    <dbReference type="PHI-base" id="PHI:2691"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990332">
        <property type="term" value="C:Ire1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd10422">
        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000077">
        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000572">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.180:FF:000002">
        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.180">
        <property type="entry name" value="KEN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045133">
        <property type="entry name" value="IRE1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010513">
        <property type="entry name" value="KEN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038357">
        <property type="entry name" value="KEN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954">
        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13954:SF6">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06479">
        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51392">
        <property type="entry name" value="KEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="601"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="KEN" evidence="22">
        <location>
            <begin position="906"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="561"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="569"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="CGD" id="CAL0131040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="CAG59035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1036" mass="119369" checksum="83938B4C8EE5657F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUR1</accession>
    <name>Q6FUR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AUS1</name>
        <name evidence="12 13" type="ordered locus">CAGL0F01419g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446033.1">
        <property type="nucleotide sequence ID" value="XM_446033.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q6FUR1"/>
    <dbReference type="FunCoup" id="Q6FUR1">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUR1"/>
    <dbReference type="TCDB" id="3.A.1.205.13">
        <property type="family name" value="the atp-binding cassette (abc) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="2887947"/>
    <dbReference type="KEGG" id="cgr:2887947"/>
    <dbReference type="CGD" id="CAL0129966">
        <property type="gene designation" value="AUS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01419g"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_35_0_1"/>
    <dbReference type="InParanoid" id="Q6FUR1"/>
    <dbReference type="OMA" id="QAIFCTI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034041">
        <property type="term" value="F:ABC-type sterol transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035376">
        <property type="term" value="P:sterol import"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001618">
        <property type="entry name" value="ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1084"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1154"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1199"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1227"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1349"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="34"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="755"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0129966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1398" mass="157977" checksum="FA784CE6A4D5D3D3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUT1</accession>
    <name>Q6FUT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0F00913g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUT1"/>
    <dbReference type="STRING" id="284593.Q6FUT1"/>
    <dbReference type="KEGG" id="cgr:2887905"/>
    <dbReference type="CGD" id="CAL0131334">
        <property type="gene designation" value="CAGL0F00913g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00913g"/>
    <dbReference type="eggNOG" id="KOG1152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004134_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FUT1"/>
    <dbReference type="OMA" id="KFANEIH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060917">
        <property type="term" value="P:regulation of (1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="946"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0131334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1206" mass="136484" checksum="CE13F1DC8F4EB0B9" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV06</accession>
    <name>Q6FV06_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0E05742g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV06"/>
    <dbReference type="FunCoup" id="Q6FV06">
        <property type="interactions" value="990"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV06"/>
    <dbReference type="KEGG" id="cgr:2887535"/>
    <dbReference type="CGD" id="CAL0129138">
        <property type="gene designation" value="CAGL0E05742g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05742g"/>
    <dbReference type="eggNOG" id="KOG2376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013808_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FV06"/>
    <dbReference type="OMA" id="ELACNER"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="552"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="584"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="633"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0129138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="647" mass="74385" checksum="B99EE9570BA647CE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV41</accession>
    <name>Q6FV41_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0E04950g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV41"/>
    <dbReference type="FunCoup" id="Q6FV41">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="ESTHER" id="canga-q6fv41">
        <property type="family name" value="Duf_676"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887344"/>
    <dbReference type="CGD" id="CAL0129118">
        <property type="gene designation" value="CAGL0E04950g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04950g"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007367_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FV41"/>
    <dbReference type="OMA" id="TIARRWH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="3">
        <location>
            <begin position="189"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0129118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="673" mass="76843" checksum="119A298BD94AAC91" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV43</accession>
    <name>Q6FV43_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0E04906g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV43"/>
    <dbReference type="FunCoup" id="Q6FV43">
        <property type="interactions" value="1436"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV43"/>
    <dbReference type="KEGG" id="cgr:2887342"/>
    <dbReference type="CGD" id="CAL0129132">
        <property type="gene designation" value="CAGL0E04906g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04906g"/>
    <dbReference type="eggNOG" id="KOG2936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049046_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FV43"/>
    <dbReference type="OMA" id="GDCEVNQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0129132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="361" mass="40066" checksum="168A7F1BF69A99D5" modified="2004-07-19" version="1">MVVHNPNNWHWVDKNCLGWAREYFQEKLVGLAAQEGDCQLSVTSVKTVDGDCEVSQRKGKVISLFDLKIVLAYDGELAGDKFEGTVSVPEVAFDSDPEDYQFVVTIFQETSKLNERVKPLIRERLVPQLRSAFQQFGPDLLTTHSSDIQVGADQVSSTFTRANQEASVPVAGASQAKAPASAQSTAKSSTQVQKPVEKATSGASASKPGTTSRVVNTSSMHLEPSFNVPAAELQRTFLDRMRLQQFSRSELRMLHSGSGSGAGGETLGEGDEYELFGGNVRTRVVSVGDSSIKLQWRLSDWTPEWFSELSIEFHESQEYHETKLKITWDKIPVGQEDRVRQNFEEYYVRAIKLTFGFGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVE0</accession>
    <name>Q6FVE0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cerevisin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0E02651g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVE0"/>
    <dbReference type="STRING" id="284593.Q6FVE0"/>
    <dbReference type="KEGG" id="cgr:2887465"/>
    <dbReference type="CGD" id="CAL0129096">
        <property type="gene designation" value="CAGL0E02651g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02651g"/>
    <dbReference type="eggNOG" id="KOG1153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_4_1"/>
    <dbReference type="InParanoid" id="Q6FVE0"/>
    <dbReference type="OMA" id="PKRGKWR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274889" description="Cerevisin" evidence="7">
        <location>
            <begin position="22"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="77"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="208"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0129096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53445" checksum="16BCDF74747FC133" modified="2004-07-19" version="1">MFSFYLITSVYYFWIFTSVDAATIPVDLSHRESASHDYTLINRLLNLWRGKGIEYNFNTGSKIYFDSAKNDMIIPNRYIVLFKDFVTDKEIQSHLSAIEEINSSSIFLQDSDFGKATQYNDISTRGIGLQHEFSIGRSMTGYIGYFTETTAKFIANSPLVELVEHDSIVRINNYKMQEHVPWGLGRISQREKLPILGKRFYHYDDRGGKDTVTFVIDTGIYVDHEDFEGRASWGKTIVENDNDYDLNGHGTHCAGTIASKHYGIAKQAEVIAVKVLRSDGSGSMSDVIRGVEYTVEAYNDLKKTKSNLKGAAGNMSLGAWKSYALNRAMDAAAAAGISFAVAAGNESDDACNSSPASAWSPITVGGSTLSDDVAFFSNYGRCVDIFAPGVNIMSTYIGSKNATESLSGTSMSSPHVAGVLAYYLSLQPDHKSQFYHEHSAISPKILKKKVLNYATNGTLSYLPAETVNLLVYNGGGKNLSKFWGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVH8</accession>
    <name>Q6FVH8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">YPS5</name>
        <name evidence="14 15" type="ordered locus">CAGL0E01771g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445766.1">
        <property type="nucleotide sequence ID" value="XM_445766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVH8"/>
    <dbReference type="STRING" id="284593.Q6FVH8"/>
    <dbReference type="MEROPS" id="A01.030"/>
    <dbReference type="GeneID" id="2887371"/>
    <dbReference type="KEGG" id="cgr:2887371"/>
    <dbReference type="CGD" id="CAL0128662">
        <property type="gene designation" value="YPS5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01771g"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="InParanoid" id="Q6FVH8"/>
    <dbReference type="OMA" id="KRWAILP"/>
    <dbReference type="PHI-base" id="PHI:7929"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05470">
        <property type="entry name" value="pepsin_retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012949221" description="Peptidase A1 domain-containing protein" evidence="12">
        <location>
            <begin position="16"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="13">
        <location>
            <begin position="51"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0128662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="519" mass="57250" checksum="41E53E1039B3F4B2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVK2</accession>
    <name>Q6FVK2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CTH2</name>
        <name evidence="8 9" type="ordered locus">CAGL0E01243g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVK2"/>
    <dbReference type="FunCoup" id="Q6FVK2">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVK2"/>
    <dbReference type="KEGG" id="cgr:2887557"/>
    <dbReference type="CGD" id="CAL0128622">
        <property type="gene designation" value="CTH2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01243g"/>
    <dbReference type="eggNOG" id="KOG1677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_604096_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVK2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000001">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000018">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="377"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0128622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="453" mass="51965" checksum="03C62DED28CA3D65" modified="2004-07-19" version="1">MSDIYTEFSESVFSERHGQHQYLKMAHANMYGNGGASEVQNVEIQPEADDYEARIKEIEEYYLKTLLNEEPSKRNSGYVGASGIKSVPSLELDDQANPSSSSSDVSIQDISTSPGMMYSKFNTHLVGNSPAVYGAAANNALFNNLNSLNESQYIYGKSINNESLYFRQQQQLQQQQQQQQQQQQLLQQQQLQQQLQLQQQQPTFLDSNVQTNYANQEFVNSQANVTPLNYTNIFNNEISAKPAKTHKINPFLQDKQVSRKSNLEVDIKHHYQANALPLTSENLQKMQDLSIDDMPIESINRKKFHIQKTTVDPTKQINSEPKVKEHQQQQQQQQINKGLYKTELCETFTTKGFCKYGNKCQFAHGLQELKLKKTSNNFRTKPCINWDKLGYCPYGKRCCFKHGDDRDIQIYKKAGTYTANPDGSDASERKLTEVQIKQKNLHANIKKLQKMTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVN8</accession>
    <name>Q6FVN8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cell division control protein 50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0E00429g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVN8"/>
    <dbReference type="FunCoup" id="Q6FVN8">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVN8"/>
    <dbReference type="KEGG" id="cgr:2887525"/>
    <dbReference type="CGD" id="CAL0128732">
        <property type="gene designation" value="CAGL0E00429g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00429g"/>
    <dbReference type="eggNOG" id="KOG2952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025025_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FVN8"/>
    <dbReference type="OMA" id="TWNNDQP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990530">
        <property type="term" value="C:Cdc50p-Drs2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015247">
        <property type="term" value="F:aminophospholipid flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0128732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44619" checksum="A0AFD99FEE09D9D7" modified="2004-07-19" version="1">MWFFKKAAEPEDSLMGTEHKSNKPPNTAFRQQRLKSWQPILSPQSVLPLLIFYACIFTPIGVGLILSAKGVQDLTIDYSHCSTKANTGDFTDIPKKYVHHNFKHKVASKARWKLENEDDESKCILEFEIPDDIKDSVYIYYKLTNFYQNHRRYVESFDYKQLLGKALSKDELTTACRPLRAEGDKIVYPCGMIANSMFNDTFDQQLKAVGDSNSDYELTNKKISWSIDRKRFKKTTYNASQIIPPPNWRERFPDGYTEDNIPNIHEWEEFQVWMRTAALPKFYKLALKNETAPLPKGTYSMAIGLHYPISYFGGSKSFVLTTNSVIGGRNMSLGVVYLIVSCLSGLLALIFIIKLFFQPRAMGDHAFLKFDEETDSRDNNDLALREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW04</accession>
    <name>Q6FW04_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0D04004g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445590.1">
        <property type="nucleotide sequence ID" value="XM_445590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW04"/>
    <dbReference type="FunCoup" id="Q6FW04">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW04"/>
    <dbReference type="KEGG" id="cgr:2887219"/>
    <dbReference type="CGD" id="CAL0128357">
        <property type="gene designation" value="CAGL0D04004g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D04004g"/>
    <dbReference type="eggNOG" id="KOG4558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058669_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FW04"/>
    <dbReference type="OMA" id="IHQMAPW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="294" mass="33470" checksum="7EF43D5E5B722520" modified="2004-07-19" version="1">MAPNSHMAPWVPMFTQSCKNAKQAFIPFQFATVAESVDGIPLPKCRTVVFRDFLFDERKTNVLTFNTDLRSNKVEESFPNGNGTCLFEACFYFHETWEQYRFTGECFLVSRKQQAIVSNETLLRYGIVDPTTFKRSESNSSVSSCSSSDEGSLPAMVDSLKLDDSKYDNHHDDGEEDIHNTDDGKVPLPTDEEWQQEIMRQWDTLSRATKSVYKKPAPGEPITEEMKKKIDKIERGVDGSKADYGLDNFAIVCLCIDKVDYLNLKGGKGGARWIFERVIDETGFETWEEQEVCP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW12</accession>
    <name>MED6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MED6</name>
        <name type="ordered locus">CAGL0D03828g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445582.1">
        <property type="nucleotide sequence ID" value="XM_445582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW12"/>
    <dbReference type="SMR" id="Q6FW12"/>
    <dbReference type="FunCoup" id="Q6FW12">
        <property type="interactions" value="899"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW12"/>
    <dbReference type="EnsemblFungi" id="CAGL0D03828g-T">
        <property type="protein sequence ID" value="CAGL0D03828g-T-p1"/>
        <property type="gene ID" value="CAGL0D03828g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887259"/>
    <dbReference type="KEGG" id="cgr:2887259"/>
    <dbReference type="CGD" id="CAL0128473">
        <property type="gene designation" value="CAGL0D03828g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03828g"/>
    <dbReference type="eggNOG" id="KOG3169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077754_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW12"/>
    <dbReference type="OMA" id="MQRQFSQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016612">
        <property type="entry name" value="Mediator_Med6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013286">
        <property type="entry name" value="MED6_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000303054" description="Mediator of RNA polymerase II transcription subunit 6">
        <location>
            <begin position="1"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="302" mass="33218" checksum="2CA20D10625EEDE3" modified="2004-07-19" version="1">MDTPLDELQWKSPEWIQAFGLRTDNVLDYFAESPFFDKTANNHVIKMQRQFSQLPNNGAAAGSMNPETMRDAHSEDMGQEQEFSYVDPIRRAILEKYVVHAFLERELMKVRGIEYVLANVREPDFWVIKKQRRTSPTAIEPLQTYYIVGANVYQSPTVFKIVQSRLLACSSHLSATLAELNNLVEFKPSQGVQYKNILDMPVTTRKTGNTANVGSVPGTISASLNMPMVNTGRLNSAGAATIGTSGVPNSAGMTGANTMATGQTGATSRFENGSSRSSTDAISTDTLDKLLITSMKSTPEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW49</accession>
    <name>Q6FW49_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0D02970g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW49"/>
    <dbReference type="FunCoup" id="Q6FW49">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW49"/>
    <dbReference type="KEGG" id="cgr:2887210"/>
    <dbReference type="CGD" id="CAL0128531">
        <property type="gene designation" value="CAGL0D02970g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02970g"/>
    <dbReference type="eggNOG" id="KOG1882">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022457_1_3_1"/>
    <dbReference type="InParanoid" id="Q6FW49"/>
    <dbReference type="OMA" id="KIPTANW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051237">
        <property type="term" value="P:maintenance of RNA location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22681">
        <property type="entry name" value="FHA_PML1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="117"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="210" mass="24234" checksum="5AE057AF9755E9D9" modified="2004-07-19" version="1">MRQSRYDATGSRAGRGISKPGYRYNNRKREWKDRREVKRTKPSKGPLLPNFESSGLLELDSNNKNGIALKYVEPKDAISPLDYFKGSTDKTKYKCLLYKESTGKVIDEFELEAKNSYLIGRKDEEEEENNIADILIPEETCSQQHCVIQFRRTENDSIKAYIIDLESSNGTVLNGNTIPQARYIELKNGDTIQFTADSRDRKYYLVYAYT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW50</accession>
    <name>BIP_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum chaperone BiP</fullName>
            <ecNumber evidence="2">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Immunoglobulin heavy chain-binding protein homolog</fullName>
            <shortName evidence="7">BiP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">KAR2</name>
        <name type="ordered locus">CAGL0D02948g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains. In the ADP-bound and nucleotide-free (apo) states, the two domains have little interaction. In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates. J domain-containing co-chaperones stimulate the ATPase activity and are required for efficient substrate recognition.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 5">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="2"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445544.1">
        <property type="nucleotide sequence ID" value="XM_445544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW50"/>
    <dbReference type="SMR" id="Q6FW50"/>
    <dbReference type="FunCoup" id="Q6FW50">
        <property type="interactions" value="1509"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW50"/>
    <dbReference type="EnsemblFungi" id="CAGL0D02948g-T">
        <property type="protein sequence ID" value="CAGL0D02948g-T-p1"/>
        <property type="gene ID" value="CAGL0D02948g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887030"/>
    <dbReference type="KEGG" id="cgr:2887030"/>
    <dbReference type="CGD" id="CAL0128341">
        <property type="gene designation" value="KAR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_D02948g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02948g"/>
    <dbReference type="eggNOG" id="KOG0100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_7_0_1"/>
    <dbReference type="InParanoid" id="Q6FW50"/>
    <dbReference type="OMA" id="VQRDIKH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034099">
        <property type="term" value="C:luminal surveillance complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070972">
        <property type="term" value="P:protein localization to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000013580" description="Endoplasmic reticulum chaperone BiP">
        <location>
            <begin position="29"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Nucleotide-binding (NBD)" evidence="2">
        <location>
            <begin position="132"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate-binding (SBD)" evidence="2">
        <location>
            <begin position="406"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="637"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Prevents secretion from ER" evidence="1">
        <location>
            <begin position="664"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="44"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="299"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="370"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P11021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P16474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="667" mass="73330" checksum="ADC5674C6F87268B" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW56</accession>
    <name>GRC3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
            <ecNumber>2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">GRC3</name>
        <name type="ordered locus">CAGL0D02816g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445538.1">
        <property type="nucleotide sequence ID" value="XM_445538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW56"/>
    <dbReference type="SMR" id="Q6FW56"/>
    <dbReference type="FunCoup" id="Q6FW56">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW56"/>
    <dbReference type="EnsemblFungi" id="CAGL0D02816g-T">
        <property type="protein sequence ID" value="CAGL0D02816g-T-p1"/>
        <property type="gene ID" value="CAGL0D02816g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887173"/>
    <dbReference type="KEGG" id="cgr:2887173"/>
    <dbReference type="CGD" id="CAL0128421">
        <property type="gene designation" value="CAGL0D02816g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02816g"/>
    <dbReference type="eggNOG" id="KOG2750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010345_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FW56"/>
    <dbReference type="OMA" id="EHVWKVR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030874">
        <property type="term" value="C:nucleolar chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002306">
        <property type="entry name" value="Grc3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000087590" description="Polynucleotide 5'-hydroxyl-kinase GRC3">
        <location>
            <begin position="1"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="247"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="630" mass="71688" checksum="E896A8BD82CDC013" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWD6</accession>
    <name>Q6FWD6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor MBP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0D01012g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to MCB elements (Mlu I cell cycle box) found in the promoter of most DNA synthesis genes. Transcriptional activation by MBF has an important role in the transition from G1 to S phase. It may have a dual role in that it behaves as an activator of transcription at the G1-S boundary and as a repressor during other stages of the cell cycle.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWD6"/>
    <dbReference type="FunCoup" id="Q6FWD6">
        <property type="interactions" value="909"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWD6"/>
    <dbReference type="KEGG" id="cgr:2887188"/>
    <dbReference type="CGD" id="CAL0128471">
        <property type="gene designation" value="CAGL0D01012g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01012g"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009666_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FWD6"/>
    <dbReference type="OMA" id="IHHAAIM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000004">
        <property type="entry name" value="Transcription factor MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF15">
        <property type="entry name" value="TRANSCRIPTION FACTOR MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="9">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="501"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="683"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0128471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="802" mass="89624" checksum="95CFE95F083B692E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWH4</accession>
    <name>Q6FWH4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Aquaporin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">AQY1</name>
        <name evidence="14 15" type="ordered locus">CAGL0D00154g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445420.1">
        <property type="nucleotide sequence ID" value="XM_445420.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FWH4">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWH4"/>
    <dbReference type="GeneID" id="2887187"/>
    <dbReference type="KEGG" id="cgr:2887187"/>
    <dbReference type="CGD" id="CAL0128279">
        <property type="gene designation" value="AQY1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00154g"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020019_1_4_1"/>
    <dbReference type="InParanoid" id="Q6FWH4"/>
    <dbReference type="OMA" id="IKLWSFW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000014">
        <property type="entry name" value="Aquaporin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0128279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31290" checksum="0E5237E535B3E940" modified="2004-07-19" version="1">METEHQADKNAELGYDSGSTVAPPNKYSTLRSRFNLGPDTMRNHVIAFFGELVGTFMFLWCAYVIANIANHDVLLDVYPDGSHPGQLIMIALGFGFSVMFSIWCFAGVSGGALNPAVSLSLALSRTITPMRCIVMWVAQMLGGMAAGGAASGMTPGPVLYANTLGNGCSRTRGLFLEMFGTTILCLTVLMTAVEKGESNFMCALPIGISLFIGHLALTGYTGTGVNPARSFGAALAARSFPVYHWIYWIGPLLGAILAWFVWQVLQWLDYSSYVTREKEAAAKTKVMVEP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2025-06-18" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWJ7</accession>
    <name>GPD2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Glycerol-3-phosphate dehydrogenase [NAD(+)] 2</fullName>
            <ecNumber>1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">GPD2</name>
        <name type="ordered locus">CAGL0C05137g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445397.1">
        <property type="nucleotide sequence ID" value="XM_445397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWJ7"/>
    <dbReference type="SMR" id="Q6FWJ7"/>
    <dbReference type="FunCoup" id="Q6FWJ7">
        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWJ7"/>
    <dbReference type="EnsemblFungi" id="CAGL0C05137g-T">
        <property type="protein sequence ID" value="CAGL0C05137g-T-p1"/>
        <property type="gene ID" value="CAGL0C05137g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886789"/>
    <dbReference type="KEGG" id="cgr:2886789"/>
    <dbReference type="CGD" id="CAL0127442">
        <property type="gene designation" value="GPD2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_C05137g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05137g"/>
    <dbReference type="eggNOG" id="KOG2711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_2_4_1"/>
    <dbReference type="InParanoid" id="Q6FWJ7"/>
    <dbReference type="OMA" id="YDTPPMD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000294">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000138087" description="Glycerol-3-phosphate dehydrogenase [NAD(+)] 2">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="69"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="422" mass="47005" checksum="4BDF81C8757F3EB9" modified="2004-07-19" version="1">MFVRLARIPRITRHYRLGLFSTQPKPKPNEYLYYRNKHKSKMEAPIKRSSSAVSLVELEREPFKVTVIGSGNWGTTIAKVVAENTKANPQVFQERVDMWVFDENIDGTMLTEIINTKHQNVKYLPNIDLPENLVANPDLLKSVEGADILVFNIPHQFLPKIVDQLRGHVEPHVRAISCLKGFEVGKKGVQLLSTYITEELGIECGALSGANLAPEVAKEHWSETTVAYHIPKDYQGDGMDVDHKVLKLLFHRPYFHVSVIDDVAGISIAGALKNVVALGCGFVEGLGWGNNAAAAIQRVGLGEIIKFGQMFFPESRVETYYQESAGVADLITTCSGGRNVRVATHMAKTGKSAEDSEKELLNGQSAQGVITCKEVHEWLSTCEMIEEFPLFEAVYKIVYEDVPMHKLPEMIEELDDIVVAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWP4</accession>
    <name>Q6FWP4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-1,3-mannosyltransferase MNT3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0C04004g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445350.1">
        <property type="nucleotide sequence ID" value="XM_445350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWP4"/>
    <dbReference type="FunCoup" id="Q6FWP4">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="CAZy" id="GT71">
        <property type="family name" value="Glycosyltransferase Family 71"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886835"/>
    <dbReference type="CGD" id="CAL0127244">
        <property type="gene designation" value="CAGL0C04004g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04004g"/>
    <dbReference type="eggNOG" id="ENOG502RZ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015387_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FWP4"/>
    <dbReference type="OMA" id="GDKEWFW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0127244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="73070" checksum="378531C4D09566A1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWQ3</accession>
    <name>URM1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">URM1</name>
        <name type="ordered locus">CAGL0C03784g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the URM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445341.1">
        <property type="nucleotide sequence ID" value="XM_445341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWQ3"/>
    <dbReference type="SMR" id="Q6FWQ3"/>
    <dbReference type="FunCoup" id="Q6FWQ3">
        <property type="interactions" value="951"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWQ3"/>
    <dbReference type="EnsemblFungi" id="CAGL0C03784g-T">
        <property type="protein sequence ID" value="CAGL0C03784g-T-p1"/>
        <property type="gene ID" value="CAGL0C03784g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886829"/>
    <dbReference type="KEGG" id="cgr:2886829"/>
    <dbReference type="CGD" id="CAL0127536">
        <property type="gene designation" value="CAGL0C03784g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_C03784g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03784g"/>
    <dbReference type="eggNOG" id="KOG4146">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148208_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWQ3"/>
    <dbReference type="OMA" id="IHFMAEK"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007114">
        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000367878" description="Ubiquitin-related modifier 1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="modified residue" description="1-thioglycine" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03048"/>
        </source>
    </evidence>
    <sequence length="98" mass="11125" checksum="FB591E7DA6F7A209" modified="2004-07-19" version="1">MVKVRVEFLGGLDVIVNKQRVYDLDVPSQVENVGDLIDYIIENLITNKKDVEVFIENDSIRPGIITLINDTDWELENEKEYVIEDGDVISFTSTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWV3</accession>
    <name>Q6FWV3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0C02629g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWV3"/>
    <dbReference type="FunCoup" id="Q6FWV3">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWV3"/>
    <dbReference type="KEGG" id="cgr:2886920"/>
    <dbReference type="CGD" id="CAL0127400">
        <property type="gene designation" value="CAGL0C02629g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02629g"/>
    <dbReference type="eggNOG" id="KOG4739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051887_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWV3"/>
    <dbReference type="OMA" id="NTQMATH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0127400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="350" mass="40061" checksum="988B7DA08AD2D3E4" modified="2004-07-19" version="1">MPENQFSQPFVHYGVCHRRHSVEDPLWLTSCAHLLCQAHLTPTKVCGVCGTRDISCLRLTNDKPLPNEVDAYFQPISGLVENMYNVCQFQYVGLLDQCNYYQKISITLKEKCNRQQQLLYKAKQELDNIPRLKRRIDELESLLKEGNYGIKKSKDNWTHTKRSLPQTVDLTIENTDQEEDQNFIQKLKNNTGLRKITPKVAPNNISAESSSHKMSITPGIFAMAESTQLISNQTTTSSVNNNQLKFKTNIHRSPSSNIMTKDSQPSNQIMPQVLNKLTMLKRNNTVSTSNLEKSNTQMATHRSYLGTYNHPNSTMLLNRRRANSQQQPKSSKQSNFEMLRRVPSSNKNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX18</accession>
    <name>Q6FX18_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">UPC2A</name>
        <name evidence="3 4" type="ordered locus">CAGL0C01199g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2022" name="Nat. Chem. Biol." volume="18" first="1253" last="1262">
            <title>Structural basis for activation of fungal sterol receptor Upc2 and azole resistance.</title>
            <authorList>
                <person name="Tan L."/>
                <person name="Chen L."/>
                <person name="Yang H."/>
                <person name="Jin B."/>
                <person name="Kim G."/>
                <person name="Im Y.J."/>
            </authorList>
            <dbReference type="PubMed" id="36229681"/>
            <dbReference type="DOI" id="10.1038/s41589-022-01117-0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 24-47</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="7VPR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.59 A"/>
        <property type="chains" value="A/B/C/D=621-922"/>
    </dbReference>
    <dbReference type="PDB" id="7VPT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A=24-47"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX18"/>
    <dbReference type="SMR" id="Q6FX18"/>
    <dbReference type="FunCoup" id="Q6FX18">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX18"/>
    <dbReference type="KEGG" id="cgr:2886777"/>
    <dbReference type="CGD" id="CAL0127396">
        <property type="gene designation" value="UPC2A"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C01199g"/>
    <dbReference type="eggNOG" id="ENOG502QRM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011669_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX18"/>
    <dbReference type="OMA" id="FHVKGAV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070452">
        <property type="term" value="P:positive regulation of ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900436">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000911">
        <property type="term" value="P:positive regulation of sterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="792"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7VPR"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7VPT"/>
        </source>
    </evidence>
    <sequence length="922" mass="100164" checksum="B05CC2C474A4467C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXA7</accession>
    <name>Q6FXA7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RPD3</name>
        <name evidence="16 17" type="ordered locus">CAGL0B01441g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445032.1">
        <property type="nucleotide sequence ID" value="XM_445032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXA7"/>
    <dbReference type="SMR" id="Q6FXA7"/>
    <dbReference type="FunCoup" id="Q6FXA7">
        <property type="interactions" value="1136"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXA7"/>
    <dbReference type="GeneID" id="2886521"/>
    <dbReference type="KEGG" id="cgr:2886521"/>
    <dbReference type="CGD" id="CAL0127744">
        <property type="gene designation" value="RPD3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01441g"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
    <dbReference type="InParanoid" id="Q6FXA7"/>
    <dbReference type="OMA" id="GKIMEWY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070211">
        <property type="term" value="C:Snt2C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045128">
        <property type="term" value="P:negative regulation of reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016479">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034503">
        <property type="term" value="P:protein localization to nucleolar rDNA repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070550">
        <property type="term" value="P:rDNA chromatin condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="15">
        <location>
            <begin position="38"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="388"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0127744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG57932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="433" mass="49082" checksum="089606CCB82119AF" modified="2004-07-19" version="1">MVYESKPFDPITVKPNDKKRVAYFYDADVGNYAYGAGHPMKPHRIRMTHSLIMNYGLYKKMEIYRAKPATKQEMCQFHTDEYIDFLSRVTPDNLEMFKKESVKFNVGDDCPVFDGLYEYCSISGGGSMEGAARLNRGKCDVAINYAGGLHHAKKSEASGFCYLNDIVLGIIELLRYHPRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKYGEFFPGTGELRDIGVGKGKYYAVNVPLRDGIDDATYRSVFEPVIGKIMEWYQPSAVVLQCGGDSLSGDRLGCFNLSMEGHANCVNYVKSFGIPMMVVGGGGYTMRNVARTWCFETGLLNNVVLDQELPYNEYYEYYGPDYKLDVRPSNMYNVNTPEYLDKILLGIFQNLENTKYAPSVQLNNVPNDPEDKGDEEEDTNEAKDTKGGSQYARDNMVQNDTEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXJ6</accession>
    <name>Q6FXJ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Telomere-associated protein Rif1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RIF1</name>
        <name evidence="3 4" type="ordered locus">CAGL0B03399g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445119.1">
        <property type="nucleotide sequence ID" value="XM_445119.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FXJ6">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXJ6"/>
    <dbReference type="GeneID" id="2886720"/>
    <dbReference type="KEGG" id="cgr:2886720"/>
    <dbReference type="CGD" id="CAL0127026">
        <property type="gene designation" value="RIF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03399g"/>
    <dbReference type="eggNOG" id="ENOG502QPT7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002800_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXJ6"/>
    <dbReference type="OMA" id="MKLEYYT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044011">
        <property type="term" value="P:single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd14267">
        <property type="entry name" value="Rif1_CTD_C-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022031">
        <property type="entry name" value="Rif1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12231">
        <property type="entry name" value="Rif1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere-associated protein Rif1 N-terminal" evidence="2">
        <location>
            <begin position="310"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1664" mass="190209" checksum="9B6EFED4C8A635B6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXX6</accession>
    <name>Q6FXX6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin structure-remodeling complex subunit SFH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0A00825g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and required for cell cycle progression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXX6"/>
    <dbReference type="STRING" id="284593.Q6FXX6"/>
    <dbReference type="KEGG" id="cgr:2886471"/>
    <dbReference type="CGD" id="CAL0126561">
        <property type="gene designation" value="CAGL0A00825g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A00825g"/>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014421_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FXX6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017393">
        <property type="entry name" value="Sfh1/SNF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038126">
        <property type="entry name" value="SWI_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0126561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG57697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="364" mass="42118" checksum="41AD61936D8CA731" modified="2004-07-19" version="1">MVKAVERRLVPQGVVTNFYNRVKEDGTIVQSLQRGGGSRRSRAVNYSEVDAFEDFEESDDERQGSNNRSASTEAVVDDKLPENVVLPDLEDIITGESDPSLNVLKFRKVRDTFFGGRIAIRYKLELDQNEVRSSSLAVPIIVPITLKLEDTADGISITDSLLWNINDTSVTPEQFSLVYCRDLGILGNNYIQQQIATLIRDQIENYRTLSGHLLQANENMRSYPDFHVHLNIACNLNSRYYEDNFQWNINDESLTPEKFATIVVKDLGLTRDFLPSISQVLHEQLLQIKKEWIKGEFNHELIHPDENNRMVRIEANQGELDRAWSPRVEVLSMDEIQKREVERERQLRRMKRDSDRLGRRGRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="154" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY00</accession>
    <name>Q6FY00_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="2 7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0A01177g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="2 7"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY00"/>
    <dbReference type="FunCoup" id="Q6FY00">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY00"/>
    <dbReference type="KEGG" id="cgr:2886477"/>
    <dbReference type="CGD" id="CAL0126527">
        <property type="gene designation" value="CAGL0A01177g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01177g"/>
    <dbReference type="eggNOG" id="KOG0169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002738_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FY00"/>
    <dbReference type="OMA" id="HWQREMS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="C2_PLC_like"/>
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        <property type="entry name" value="EFh_ScPlc1p_like"/>
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        <property type="entry name" value="PH_PLC_fungal"/>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="C2_domain_sf"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="Plc1_PH"/>
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    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
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        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
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        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
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        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
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    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PLCYc"/>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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        <property type="entry name" value="PH domain-like"/>
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    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF_HAND_2"/>
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        <property type="entry name" value="PIPLC_X_DOMAIN"/>
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    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="270"/>
            <end position="305"/>
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    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="582"/>
            <end position="698"/>
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        <location>
            <begin position="1"/>
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        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0126527"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG57713.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="850" mass="97566" checksum="9C3C81CA999CDF2D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY88</accession>
    <name>Q6FY88_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxisomal membrane protein PEX13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Peroxin-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PEX13</name>
        <name evidence="17 18" type="ordered locus">CAGL0A04147g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domain) with PEX14 (via SH3-binding motif); forming the PEX13-PEX14 docking complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxin-13 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG57840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444947.1">
        <property type="nucleotide sequence ID" value="XM_444947.1"/>
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        <property type="interactions" value="201"/>
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        <property type="gene designation" value="PEX13"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04147g"/>
    <dbReference type="eggNOG" id="KOG3875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034386_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FY88"/>
    <dbReference type="OMA" id="EGWFPKK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006625">
        <property type="term" value="P:protein targeting to peroxisome"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd11771">
        <property type="entry name" value="SH3_Pex13p_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peroxisomal membrane protein (Pex13)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007223">
        <property type="entry name" value="Peroxin-13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04088">
        <property type="entry name" value="Peroxin-13_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SH3" evidence="16">
        <location>
            <begin position="314"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0126755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG57840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="391" mass="42811" checksum="C509ADE8368E9B46" modified="2004-07-19" version="1">MTYTETRPKPWETNGGTTAAVDRAFDIENEANNSLMSTRDTTTQESHEQGTREGSEPPEVVPRPPGLTNTMNGGVGTGMYNSGGYGYDSGIYGGGMYGNNGGMFGSMYSGAMNRYGGMYGGGYGNYGSFYNNGYNYGGAYGDMGGNGLEQIGESTRATFQLIESLIGAVTGFAQMLESTYMATHNSFFTMISVAEQFNYLKEVLGSAFGIFAIMKFLKRLLYFVTNGRLGSAPKRIQGGGNSGNSRLLEEFSRFGLNNDKAPARKITLKPLLFFLSAVFGFPYLLNKFIQKLQEVQQRNSIAMGKDGDGTIDPSKLEFARALYDFTPENPQIEITLKKGDLVAIISKADPLGRSSDWWKVRNRAGQNGYAPYNYLEIIKRVKKQESKTPPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-10" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q96UP2</accession>
    <name>NEP1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase NEP1</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">18S rRNA (pseudouridine-N1)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NEP1</name>
        <name type="synonym">EMG1</name>
        <name type="ordered locus">CAGL0B01232g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Curr. Genet." volume="40" first="326" last="338">
            <title>Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis.</title>
            <authorList>
                <person name="Eschrich D."/>
                <person name="Buchhaupt M."/>
                <person name="Koetter P."/>
                <person name="Entian K.-D."/>
            </authorList>
            <dbReference type="PubMed" id="11935223"/>
            <dbReference type="DOI" id="10.1007/s00294-001-0269-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Genome Biol." volume="4" first="R10.1" last="R10.9">
            <title>Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata.</title>
            <authorList>
                <person name="Wong S."/>
                <person name="Fares M.A."/>
                <person name="Zimmermann W."/>
                <person name="Butler G."/>
                <person name="Wolfe K.H."/>
            </authorList>
            <dbReference type="PubMed" id="12620120"/>
            <dbReference type="DOI" id="10.1186/gb-2003-4-2-r10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates the pseudouridine corresponding to position 1189 (Psi1189) in S.cerevisiae 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a pseudouridine in rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46696"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:13933"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="AY034788">
        <property type="protein sequence ID" value="AAK61538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY181247">
        <property type="protein sequence ID" value="AAO25590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445023.1">
        <property type="nucleotide sequence ID" value="XM_445023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q96UP2"/>
    <dbReference type="SMR" id="Q96UP2"/>
    <dbReference type="FunCoup" id="Q96UP2">
        <property type="interactions" value="1032"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q96UP2"/>
    <dbReference type="EnsemblFungi" id="CAGL0B01232g-T">
        <property type="protein sequence ID" value="CAGL0B01232g-T-p1"/>
        <property type="gene ID" value="CAGL0B01232g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886681"/>
    <dbReference type="KEGG" id="cgr:2886681"/>
    <dbReference type="CGD" id="CAL0127832">
        <property type="gene designation" value="EMG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01232g"/>
    <dbReference type="eggNOG" id="KOG3073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055846_1_1_1"/>
    <dbReference type="InParanoid" id="Q96UP2"/>
    <dbReference type="OMA" id="VHNTFEL"/>
    <dbReference type="BRENDA" id="2.1.1.260">
        <property type="organism ID" value="1113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000158611" description="Ribosomal RNA small subunit methyltransferase NEP1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes Arg-67" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q06287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="229" mass="25596" checksum="E4BED261436D0314" modified="2001-12-01" version="1">MVEDSKARIGGPNNSSVTKKQEPRLYVVLCEASLETYTSNDHRTSLLNCDDHQGILRKMGRDIAEARPDITHQCLLTLLDSPINKAGLLQVYILTKKNVLIEVNPSVRIPRTFKRFSGLMVQLLHKLSIRSMESSNTHLLRVVKNPVTKYLPADCRKVTLSFDAEVMRPQEYLGDKQSVCVFVGAMARGHDSFADEYVDDKIAISNYPLSASVACSKFCHGAEDAWAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN64</accession>
    <name>B4UN64_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein SSS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0M11104g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAR58080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN64"/>
    <dbReference type="FunCoup" id="B4UN64">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UN64"/>
    <dbReference type="KEGG" id="cgr:9488063"/>
    <dbReference type="CGD" id="CAL0136407">
        <property type="gene designation" value="CAGL0M11104g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11104g"/>
    <dbReference type="eggNOG" id="KOG3498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167752_2_0_1"/>
    <dbReference type="InParanoid" id="B4UN64"/>
    <dbReference type="OMA" id="KPDQKEY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071261">
        <property type="term" value="C:Ssh1 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0136407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAR58080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="72" mass="8036" checksum="EA0D84E601801987" modified="2008-09-23" version="1">MAKNEKGENKEQILDAPMEFVKEGSQFLSKCKKPDLKEYTKIVKAVGIGFVAVGVIGYAIKLIHIPIRYVIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1992-05-01" modified="2025-06-18" version="162" xmlns="https://uniprot.org/uniprot">
    <accession>P25400</accession>
    <name>CYC_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Cytochrome c</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CYC1</name>
        <name type="ordered locus">CAGL0I01408g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1991" name="Curr. Genet." volume="20" first="195" last="198">
            <title>Contrasting mutation rates in mitochondrial and nuclear genes of yeasts versus mammals.</title>
            <authorList>
                <person name="Clark-Walker G.D."/>
            </authorList>
            <dbReference type="PubMed" id="1657417"/>
            <dbReference type="DOI" id="10.1007/BF00326232"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text>Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text>Loosely associated with the inner membrane.</text>
    </comment>
    <comment type="PTM">
        <text>Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="online information" name="Protein Spotlight">
        <link uri="https://www.proteinspotlight.org/back_issues/076"/>
        <text>Life shuttle - Issue 76 of November 2006</text>
    </comment>
    <dbReference type="EMBL" id="X58249">
        <property type="protein sequence ID" value="CAA41203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="S16761">
        <property type="entry name" value="S16761"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447316.1">
        <property type="nucleotide sequence ID" value="XM_447316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P25400"/>
    <dbReference type="SMR" id="P25400"/>
    <dbReference type="FunCoup" id="P25400">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="STRING" id="284593.P25400"/>
    <dbReference type="EnsemblFungi" id="CAGL0I01408g-T">
        <property type="protein sequence ID" value="CAGL0I01408g-T-p1"/>
        <property type="gene ID" value="CAGL0I01408g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888955"/>
    <dbReference type="KEGG" id="cgr:2888955"/>
    <dbReference type="CGD" id="CAL0132740">
        <property type="gene designation" value="CYC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I01408g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01408g"/>
    <dbReference type="eggNOG" id="KOG3453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060944_3_0_1"/>
    <dbReference type="InParanoid" id="P25400"/>
    <dbReference type="OMA" id="KARCAQC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0679">Respiratory chain</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000108319" description="Cytochrome c">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="2">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="2">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="modified residue" description="N6,N6,N6-trimethyllysine" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="104" mass="11546" checksum="35DE0EACABFE39C1" modified="1992-05-01" version="1">MSEKKGATLFKTRCLQCHTVEKGGPNKVGPNLHGIFGRKSGQAAGYSYTDANIKKNVTWDEDNMSDYLTNPKKYIPGTKMAFGGLKKEKDRKDLIAYLKKATSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIJ6</accession>
    <name>EIF3C_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="1">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 93 kDa subunit homolog</fullName>
            <shortName evidence="1">eIF3 p93</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Translation initiation factor eIF3, p93 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NIP1</name>
        <name type="ordered locus">CAGL0M13893g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449948.1">
        <property type="nucleotide sequence ID" value="XM_449948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIJ6"/>
    <dbReference type="SMR" id="Q6FIJ6"/>
    <dbReference type="FunCoup" id="Q6FIJ6">
        <property type="interactions" value="1275"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIJ6"/>
    <dbReference type="EnsemblFungi" id="CAGL0M13893g-T">
        <property type="protein sequence ID" value="CAGL0M13893g-T-p1"/>
        <property type="gene ID" value="CAGL0M13893g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891610"/>
    <dbReference type="KEGG" id="cgr:2891610"/>
    <dbReference type="CGD" id="CAL0137483">
        <property type="gene designation" value="CAGL0M13893g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13893g"/>
    <dbReference type="eggNOG" id="KOG1076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004304_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FIJ6"/>
    <dbReference type="OMA" id="FRCGLIK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000364279" description="Eukaryotic translation initiation factor 3 subunit C">
        <location>
            <begin position="1"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="605"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="810" mass="92915" checksum="6F84E9CFBF1C2F03" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIK7</accession>
    <name>Q6FIK7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carboxypeptidase</fullName>
            <ecNumber evidence="11">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0M13651g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="11"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIK7"/>
    <dbReference type="FunCoup" id="Q6FIK7">
        <property type="interactions" value="921"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIK7"/>
    <dbReference type="ESTHER" id="canga-q6fik7">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="MEROPS" id="S10.001"/>
    <dbReference type="KEGG" id="cgr:2891228"/>
    <dbReference type="CGD" id="CAL0137301">
        <property type="gene designation" value="CAGL0M13651g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13651g"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_10_4_1"/>
    <dbReference type="InParanoid" id="Q6FIK7"/>
    <dbReference type="OMA" id="GDWMKPF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046938">
        <property type="term" value="P:phytochelatin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006529159" description="Carboxypeptidase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0137301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG62917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="508" mass="57212" checksum="2154CE459780AEAE" modified="2004-07-19" version="1">MKLAYLAGVAAVLSQVDAFSLSGAQDYFYNKSPVQNTLKNIFPAHLDDISFGTRRRSGIKKKKNWDAVVKMEGLEGHQLRVNKIVNPKKLGVDPHVKQLTGYLDNELEDKHFFFWFFESRNDPKNDPVILWLNGGPGCSSLTGLFFELGPSSIDGQKLKPVKNPFSWNSNASVIFLDQPVNVGFSYAGSNSNGGVSNTVAAGKDVYAFLQLFFKQFPQYADGQDFHIAGESYAGHYIPVFASEILAHPQKERHFNLTSVLIGNGLTDPLTQYRYYKPMACGEGSGADPVLSPEECSAMEDSLDRCLSLIDACYQSESVWACVPASIYCNNAQLAPYQRTGRNVYDVRKDCEGGSLCYPELQNIDDYLNMDYVREAVGAEVDHYESCNFDINRNFLFNGDWMKPYHKQVIEILEKGLPVLIYAGDKDFICNWMGNRAWTDELQWKYSSGFAQEPVRNWTASITGEVAGEVKSYENLTFLRLFDGGHMVPYDQPESSLSMLNEWIHKFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ13</accession>
    <name>Q6FJ13_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0M09999g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q6FJ13"/>
    <dbReference type="FunCoup" id="Q6FJ13">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ13"/>
    <dbReference type="KEGG" id="cgr:2891345"/>
    <dbReference type="CGD" id="CAL0137241">
        <property type="gene designation" value="CAGL0M09999g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09999g"/>
    <dbReference type="eggNOG" id="KOG1826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000439_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ13"/>
    <dbReference type="OMA" id="CPANDID"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05392">
        <property type="entry name" value="RasGAP_Neurofibromin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF142">
        <property type="entry name" value="NEUROFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="1746"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="940"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="940"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="961"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1062"/>
            <end position="1073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0137241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="3124" mass="355883" checksum="782988F37865A13E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ46</accession>
    <name>EAF6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EAF6</name>
        <name type="ordered locus">CAGL0M09295g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449748.1">
        <property type="nucleotide sequence ID" value="XM_449748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ46"/>
    <dbReference type="SMR" id="Q6FJ46"/>
    <dbReference type="FunCoup" id="Q6FJ46">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ46"/>
    <dbReference type="EnsemblFungi" id="CAGL0M09295g-T">
        <property type="protein sequence ID" value="CAGL0M09295g-T-p1"/>
        <property type="gene ID" value="CAGL0M09295g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891312"/>
    <dbReference type="KEGG" id="cgr:2891312"/>
    <dbReference type="CGD" id="CAL0136263">
        <property type="gene designation" value="CAGL0M09295g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M09295g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09295g"/>
    <dbReference type="eggNOG" id="KOG3856">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093901_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FJ46"/>
    <dbReference type="OMA" id="FVKQQEG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990468">
        <property type="term" value="C:NuA3b histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000086895" description="Chromatin modification-related protein EAF6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="91" mass="10551" checksum="790F0A9E2E6FA20E" modified="2004-07-19" version="1">MSDEYQSVKQELKALLADRKELEDKLDKLQQEIYDKESEYFDVDGGSKSYHNILRGFDGMSRTQSNNSNMTNNDRIFSLSSASYVKQVQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ57</accession>
    <name>Q6FJ57_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinate/fumarate mitochondrial transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0M09020g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
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                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
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                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="cgr:2891299"/>
    <dbReference type="CGD" id="CAL0136871">
        <property type="gene designation" value="CAGL0M09020g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09020g"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_0_1"/>
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    <dbReference type="OMA" id="KDWYKGG"/>
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        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
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        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
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        <location>
            <begin position="239"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0136871"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG62713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="37223" checksum="862B8438DD86FD46" modified="2004-07-19" version="1">MSSSKKKSSNPVVNLVAGGTAGLFEALCCHPLDTIKVRMQIYKRQAAPAAAAVASMAGGAGGAATATVGGGDATAAIKPPGFIRTGRNIYAQEGFLALYKGLGAVVIGIIPKMAIRFSSYEFYRTLLADKQTGVVSTSNTFIAGVGAGVTEAVLVVNPMEVVKIRLQAQHLNPNHDLAKPKYTNAVQAGYTIIKEEGISALYRGVSLTAARQATNQGANFTVYSKLREFLQEYHGTETLPSWETSCIGLISGAIGPFSNAPLDTIKTRLQKDKSTSFKGESGWKRIAHIGTQLLKEEGFRALYKGITPRVMRVAPGQAVTFTVYEFVRRHLENLGVFSKPTPKPKKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ90</accession>
    <name>Q6FJ90_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc-regulated transporter 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M08250g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAG62680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ90"/>
    <dbReference type="FunCoup" id="Q6FJ90">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ90"/>
    <dbReference type="KEGG" id="cgr:2891263"/>
    <dbReference type="CGD" id="CAL0136997">
        <property type="gene designation" value="CAGL0M08250g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08250g"/>
    <dbReference type="eggNOG" id="KOG2474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023518_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ90"/>
    <dbReference type="OMA" id="GTTCLKW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="63729" checksum="C905F7AC4EE937C3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJI6</accession>
    <name>Q6FJI6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Prephenate dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="9">PRDH</shortName>
            <ecNumber evidence="9">1.3.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0M06017g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21640"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:36242"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8 9">Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the prephenate/arogenate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.13" evidence="9"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJI6"/>
    <dbReference type="FunCoup" id="Q6FJI6">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJI6"/>
    <dbReference type="KEGG" id="cgr:2891656"/>
    <dbReference type="CGD" id="CAL0136567">
        <property type="gene designation" value="CAGL0M06017g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06017g"/>
    <dbReference type="eggNOG" id="KOG2380">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031403_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FJI6"/>
    <dbReference type="OMA" id="WRVNACD"/>
    <dbReference type="UniPathway" id="UPA00122">
        <property type="reaction ID" value="UER00962"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000002">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3660.10:FF:000004">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000339">
        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3660.10">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
        <property type="entry name" value="PDH_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0521">NADP</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0827">Tyrosine biosynthesis</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="10">
        <location>
            <begin position="10"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0136567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG62584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="446" mass="50765" checksum="B4605C2F711EAE5C" modified="2004-07-19" version="1">MMEEQWQANKVIGIIGLGDMGLLYATKFSSAGWKVVACDREELFDSLSERKRQNAWKFDIVKNGHYVSRISDYIIYSVEAENIDKLVKLYGPSTKVGAIVGGQTSCKTPEIKAFEKYLPEDVEIITLHSLHGPKVNTEGQPLVLINHRSKTDESMKFIESLVSCLKSKQVYLTYEEHDRITADTQAVTHAAFLSMGRAWAKLKVYPWTLGVNKWYGGLENVKVNISLRIYSNKWHVYAGLALTNPMAHKQILQYATSATELFTLFLDKKKDELTERLNKAKEFVFGNHTGLLLLDDTIFEKYSLSKDSASSDSKESTSLPNSHLSLLAIVDSWHQLGINPYDHMICSTPLFRIFLGVSEFLFLSPDLLEKTIDAAIDDHSFRRDDLEFVVAAREWSSIVTFGNFDLYKRQFEDVQKFFEPMLPEANQIGNEMIKTILMHSQDSKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJJ2</accession>
    <name>Q6FJJ2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein LAS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M05885g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJJ2"/>
    <dbReference type="FunCoup" id="Q6FJJ2">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJJ2"/>
    <dbReference type="KEGG" id="cgr:2891650"/>
    <dbReference type="CGD" id="CAL0136653">
        <property type="gene designation" value="CAGL0M05885g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05885g"/>
    <dbReference type="eggNOG" id="KOG2425">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043823_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJJ2"/>
    <dbReference type="OMA" id="HWGTHER"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="57496" checksum="B6D47FDDD323AE15" modified="2004-07-19" version="1">MSHGRVVPWKDEKELDELKQWFYSVSDGNDLRLKAISRVKSYKLKGSQYLPHVIDSTAQLTSAILADEKHGGSDDLFDKMNIRMTYTMAMIRFVNGVLDPSQQTQFAIPLHTIARNVGLPSWFVDLRHWGTHERDLPNIDMLRMAAKDALQWLWKNYWDNDELDDSLNEDDALDEETIRQQEYLDRLRLKIELWKNNNTELRDNCNIWLEEKNSIISSDNFVVDDGGKTNSSKADQLVKFIDETITEVKYLWKVIRDKNLFMRTFLKFYDDLFLSLLVRKLPGFDLELIKWMFSAYTVLYQDGNLELKQDLYAIRSRFSKWIVLEKELLSPLVSLLNIRSRISELSELFNPDMTFMQFKLLSLLVKKLEEDIGNHNWRRKKRRKDNNDTTAKLNDTQRQWNQLVADYLKSHVMLEEEKQFSMYGAKAKAVVKKAKEASVHNNELSDDLQKLKQRLLNLKSKESVKPPSIETFNWDSHDDWQPKPFGIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJV4</accession>
    <name>EAF5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Chromatin modification-related protein EAF5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EAF5</name>
        <name type="ordered locus">CAGL0M03289g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449490.1">
        <property type="nucleotide sequence ID" value="XM_449490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJV4"/>
    <dbReference type="SMR" id="Q6FJV4"/>
    <dbReference type="FunCoup" id="Q6FJV4">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJV4"/>
    <dbReference type="EnsemblFungi" id="CAGL0M03289g-T">
        <property type="protein sequence ID" value="CAGL0M03289g-T-p1"/>
        <property type="gene ID" value="CAGL0M03289g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891498"/>
    <dbReference type="KEGG" id="cgr:2891498"/>
    <dbReference type="CGD" id="CAL0136813">
        <property type="gene designation" value="CAGL0M03289g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M03289g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03289g"/>
    <dbReference type="HOGENOM" id="CLU_1337349_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJV4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990453">
        <property type="term" value="C:nucleosome disassembly/reassembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026226">
        <property type="entry name" value="EAF5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02067">
        <property type="entry name" value="PROTEINEAF5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000086890" description="Chromatin modification-related protein EAF5">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="205" mass="23848" checksum="4FEDA591D0EB9AAF" modified="2004-07-19" version="1">MNEEIQTLLIYQICDSLRFQANMEDISVDDVMDVMQENIMVECLLDGVIMDKADVQKIVIQYVTDGELGEEAIGDKMESMYSNSRKKLLKEIDDLDNTISTNRKKDKLLNLYRDTVLNRLQNKKTVLDKLYHGMKEDSSVIRNRIYLERIKNETPNSIAELQLMLQRSIADCIMSEPIGSEKYNIAKEIQINLEDTIRFMKRALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJW6</accession>
    <name>Q6FJW6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0M03025g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJW6"/>
    <dbReference type="FunCoup" id="Q6FJW6">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJW6"/>
    <dbReference type="KEGG" id="cgr:2891486"/>
    <dbReference type="CGD" id="CAL0137047">
        <property type="gene designation" value="CAGL0M03025g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03025g"/>
    <dbReference type="eggNOG" id="ENOG502QTKQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004300_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FJW6"/>
    <dbReference type="OMA" id="FLAKCMI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000876">
        <property type="term" value="P:positive regulation of glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15485">
        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="124"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="951"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="684"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="959"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0137047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1254" mass="140737" checksum="537C5C0D1019937D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK57</accession>
    <name>Q6FK57_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-rRNA-processing protein TSR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0M00946g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK57"/>
    <dbReference type="FunCoup" id="Q6FK57">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK57"/>
    <dbReference type="KEGG" id="cgr:2891156"/>
    <dbReference type="CGD" id="CAL0136663">
        <property type="gene designation" value="CAGL0M00946g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00946g"/>
    <dbReference type="eggNOG" id="KOG4032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074896_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FK57"/>
    <dbReference type="OMA" id="QSNWGGP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0136663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24103" checksum="9276E838AB6B5FA3" modified="2004-07-19" version="1">MEFDETVYVEAPQGQGNLMFSDEKQQARFELGCSMMVYKWDALDIAVDNQWGGPESAEKRDWITGIIVDLFKNEKIVDAALLEETLLYAMVDEFDTNVEDDSALPIATGIIQVYKDCAAQNYQIVEQLYLEWQSKEKNKPQRVIKVTGDDESSSDEDDEDEEYMNGATGEDTHMHYEEIDVDMENDKSRSEPIVDDDGFELVQKKGKRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK90</accession>
    <name>Q6FK90_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0M00220g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK90"/>
    <dbReference type="FunCoup" id="Q6FK90">
        <property type="interactions" value="577"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK90"/>
    <dbReference type="CAZy" id="GT39">
        <property type="family name" value="Glycosyltransferase Family 39"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891148"/>
    <dbReference type="CGD" id="CAL0137091">
        <property type="gene designation" value="CAGL0M00220g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00220g"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK90"/>
    <dbReference type="OMA" id="NCHLNAP"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097586">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900101">
        <property type="term" value="P:regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="595"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="717"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="337"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="403"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="468"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0137091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG62330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="765" mass="88002" checksum="EF9F61A1AED8BC66" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKA4</accession>
    <name>Q6FKA4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAGL0L13134g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKA4"/>
    <dbReference type="FunCoup" id="Q6FKA4">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890590"/>
    <dbReference type="eggNOG" id="KOG1032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015638_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKA4"/>
    <dbReference type="OMA" id="RWNDATS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="9">
        <location>
            <begin position="402"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="582"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="725" mass="80855" checksum="855D38BA74B55D93" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKG4</accession>
    <name>PABP_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Polyadenylate-binding protein, cytoplasmic and nuclear</fullName>
            <shortName>PABP</shortName>
            <shortName>Poly(A)-binding protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Polyadenylate tail-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PAB1</name>
        <name type="ordered locus">CAGL0L11792g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449280.1">
        <property type="nucleotide sequence ID" value="XM_449280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKG4"/>
    <dbReference type="SMR" id="Q6FKG4"/>
    <dbReference type="FunCoup" id="Q6FKG4">
        <property type="interactions" value="1550"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKG4"/>
    <dbReference type="EnsemblFungi" id="CAGL0L11792g-T">
        <property type="protein sequence ID" value="CAGL0L11792g-T-p1"/>
        <property type="gene ID" value="CAGL0L11792g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890944"/>
    <dbReference type="KEGG" id="cgr:2890944"/>
    <dbReference type="CGD" id="CAL0135516">
        <property type="gene designation" value="CAGL0L11792g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L11792g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11792g"/>
    <dbReference type="eggNOG" id="KOG0123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_22_4_1"/>
    <dbReference type="InParanoid" id="Q6FKG4"/>
    <dbReference type="OMA" id="NATYSMA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008428">
        <property type="term" value="F:ribonuclease inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060211">
        <property type="term" value="P:regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000211">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000648">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000295385" description="Polyadenylate-binding protein, cytoplasmic and nuclear">
        <location>
            <begin position="1"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 1" evidence="2">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 2" evidence="2">
        <location>
            <begin position="123"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 3" evidence="2">
        <location>
            <begin position="216"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 4" evidence="2">
        <location>
            <begin position="319"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="3">
        <location>
            <begin position="487"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="566"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="579" mass="64667" checksum="81BB5C4C7D35F798" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKS7</accession>
    <name>Q6FKS7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pseudouridine synthase I TruA alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L08998g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKS7"/>
    <dbReference type="FunCoup" id="Q6FKS7">
        <property type="interactions" value="752"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKS7"/>
    <dbReference type="KEGG" id="cgr:2891098"/>
    <dbReference type="CGD" id="CAL0135330">
        <property type="gene designation" value="CAGL0L08998g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08998g"/>
    <dbReference type="eggNOG" id="KOG2554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FKS7"/>
    <dbReference type="OMA" id="DCKFPEM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02569">
        <property type="entry name" value="PseudoU_synth_ScPus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000020">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000012">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041707">
        <property type="entry name" value="Pus3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="6">
        <location>
            <begin position="233"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="438" mass="51017" checksum="8D54C288E13D9A4A" modified="2004-07-19" version="1">MWSFIKKFIDHPPPSTTKVQKDIVEKFSRNSSYESWNKEDLIQRILELEKVSKVKKREHPDEVIDLKKDKKAKKQKTFDFSKYNTRFIALRFAYLGWNYNGLAIQKDPTPLPTIEGTIIEALNKCKLVPSITPQEFEFSRCGRTDKGVSAMNQVISLRVRSNLTDEEQKDPRNDHKEIQYVAILNQLLPDDIRISAVCLRPPNSFDARFSCEYRHYKYLFHKDGLDLDRMQKAAKLYEGEHDFRNFCKLDGSKQITNYNRTMISANIKHVYNDFYCFDLIGSAFLWHQVRCMTAILFLVGQGLEEPTLIEKMLDVTSMPQKPMYEMASDIPLLLYDCKFPAMEWQEANLNDYKSVKYGKAVSALALDYHLKATVVEIFKNTLPTSDIEFSGKTRINLGDGKGKVVTDYEKMLDRQVMATVEEVNSKYLERKKRNPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKZ6</accession>
    <name>Q6FKZ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L07370g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKZ6"/>
    <dbReference type="FunCoup" id="Q6FKZ6">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKZ6"/>
    <dbReference type="KEGG" id="cgr:2890986"/>
    <dbReference type="CGD" id="CAL0135630">
        <property type="gene designation" value="CAGL0L07370g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07370g"/>
    <dbReference type="eggNOG" id="KOG2388">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025603_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FKZ6"/>
    <dbReference type="OMA" id="YFQVDNP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="472" mass="52988" checksum="33A7E05CEB8EE74C" modified="2004-07-19" version="1">MGVCEQYKTAGQDQLFEHFESLEKNEQQTLLDNLEKVANRVSPEKLVSDCKKAIQLAEENSKAGSHIQPLPSSSYESIIDNREAETRYFNKGVESLERSEVGVILLAGGQGTRLGSSAPKGCYDIGLPSGKSLFQIQAERIYRLQKLVGKNCKIPWYIMTSEPTRNATEQFFKENNYFGLNHGDITFFNQGTLPAFDLKGEKLLLGSPTSLVQSPDGNGGLYRAIKENNLVDDFNKRGIKHLYMYCVDNVLSLAADPTFIGYAIEHKFELATKAVRKRDAHESVGLIATKDKRPCVIEYSEISKELAEATDNQGLLKLRAANIVNHYYSVNLLERELDNWCDNMSYHIAKKKIPIYNNKTGEFEKPETPNGIKLEQFIFDVFPTIPMEKFGCLEVQRSKEFSPLKNGPGSANDNPETSRTAYLKLGTSWLRSAGAVIDDNILVEVSSATTYKGENLSQFKGYKFDKNNSYVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL66</accession>
    <name>Q6FL66_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0L05830g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449028.1">
        <property type="nucleotide sequence ID" value="XM_449028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL66"/>
    <dbReference type="KEGG" id="cgr:2890808"/>
    <dbReference type="CGD" id="CAL0135390">
        <property type="gene designation" value="CAGL0L05830g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05830g"/>
    <dbReference type="HOGENOM" id="CLU_1277476_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL66"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0135390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="216" mass="25359" checksum="F3E0770E08BB5ADB" modified="2004-07-19" version="1">MAHSRTFTEQLHHLRCLNDEILKTTDDINESLVESEITHIESKSVGESITTATTTTFTMKQNSEIVHYLLPFLNSLIKSFYSFYEHINDVEQLDFQFSQFRKSMTFSPVCKFSHNTTQTKDLVGTEVVNKNEWYEYHNGNMTKLFEILDTILILQTQLLNAYNNKHNSLKTNYQLDILYSIFIDPKSYGLKESDHVKSLRLEMFNVLLELFKSEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL69</accession>
    <name>Q6FL69_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial RNA-splicing protein MRS3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0L05742g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL69"/>
    <dbReference type="STRING" id="284593.Q6FL69"/>
    <dbReference type="KEGG" id="cgr:2890804"/>
    <dbReference type="CGD" id="CAL0135616">
        <property type="gene designation" value="CAGL0L05742g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05742g"/>
    <dbReference type="eggNOG" id="KOG0760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FL69"/>
    <dbReference type="OMA" id="CVRTVTH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="119"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="208"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0135616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33486" checksum="30850F82144F43F3" modified="2004-07-19" version="1">MESSDVIDYEALPDHAPLAHQLMAGAFAGIAEHSVIFPLDALKTRLQAMHAISTTGGQPIPSTMLRQLSSISAQEGSMVLWKGVQSVLLGAGPAHAVYFATYEMVKSFLIDEATSTSKYHFFKTAFSGATATIAADALMNPFDVIKQRIQLNTNISVWDTAKRIYSKEGFQAFYSSYPTTLAINIPFAAFNFGIYDTATRYFNPSGVYNPFIHCLCGGISGAACAGLTTPLDCIKTALQVRGSEKVSMEVFKQADTFKKATRAIYQVYGWRGFWSGVKPRILANMPATAISWTAYEFAKHFLFHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLE9</accession>
    <name>Q6FLE9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0L03938g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448945.1">
        <property type="nucleotide sequence ID" value="XM_448945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLE9"/>
    <dbReference type="FunCoup" id="Q6FLE9">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLE9"/>
    <dbReference type="ESTHER" id="canga-q6fle9">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890548"/>
    <dbReference type="CGD" id="CAL0136036">
        <property type="gene designation" value="CAGL0L03938g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03938g"/>
    <dbReference type="eggNOG" id="ENOG502QQW9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028296_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLE9"/>
    <dbReference type="OMA" id="ISRYCYW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000322">
        <property type="entry name" value="Integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019431">
        <property type="entry name" value="DUF2417"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052370">
        <property type="entry name" value="Meta-cleavage_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139">
        <property type="entry name" value="SI:DKEY-122A22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139:SF52">
        <property type="entry name" value="SI:DKEY-122A22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10329">
        <property type="entry name" value="DUF2417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="355"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0136036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="637" mass="73945" checksum="D107B616C63CB755" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLF8</accession>
    <name>RPIA_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Ribose-5-phosphate isomerase</fullName>
            <ecNumber>5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RKI1</name>
        <name type="ordered locus">CAGL0L03740g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448936.1">
        <property type="nucleotide sequence ID" value="XM_448936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLF8"/>
    <dbReference type="SMR" id="Q6FLF8"/>
    <dbReference type="FunCoup" id="Q6FLF8">
        <property type="interactions" value="985"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLF8"/>
    <dbReference type="EnsemblFungi" id="CAGL0L03740g-T">
        <property type="protein sequence ID" value="CAGL0L03740g-T-p1"/>
        <property type="gene ID" value="CAGL0L03740g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890542"/>
    <dbReference type="KEGG" id="cgr:2890542"/>
    <dbReference type="CGD" id="CAL0135496">
        <property type="gene designation" value="RKI1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03740g"/>
    <dbReference type="eggNOG" id="KOG3075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056590_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLF8"/>
    <dbReference type="OMA" id="ACHVQEK"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000014">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000053">
        <property type="entry name" value="Ribose-5-phosphate isomerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001924">
        <property type="entry name" value="PRK00702.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000339885" description="Ribose-5-phosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="260" mass="28519" checksum="D61966268ECD9216" modified="2004-07-19" version="1">MSYTPLPNINDFPTLGNPLEDAKRAAAYRAVDENLNFDEHRIIGVGSGSTVVYVAERIGQYLKDEKYHDKVSKFICIPTGYQSRNLIQDNGLILGSIEQHPHVDIAFDGADEVDHNLQLIKGGGACLFQEKLVSTSAKIFIVVADSRKKSDTNLGINWKRGVPIEIVPSAWSRVQHDLTSILHANSAPVRQGGSAKAGPVVTDNMNFLIDADFGEIQDPKALHEQIKMLVGVVETGLFIDNAHRAYFGKPDGSVEVIDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLG0</accession>
    <name>Q6FLG0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ECM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L03696g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLG0"/>
    <dbReference type="FunCoup" id="Q6FLG0">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLG0"/>
    <dbReference type="KEGG" id="cgr:2890537"/>
    <dbReference type="CGD" id="CAL0136030">
        <property type="gene designation" value="CAGL0L03696g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03696g"/>
    <dbReference type="eggNOG" id="ENOG502QU6H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021924_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLG0"/>
    <dbReference type="OMA" id="TAQFIDT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040254">
        <property type="entry name" value="Ecm3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274:SF3">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="67544" checksum="584464185821D211" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLJ9</accession>
    <name>Q6FLJ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23 24" type="ordered locus">CAGL0L02849g</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 26">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLJ9"/>
    <dbReference type="FunCoup" id="Q6FLJ9">
        <property type="interactions" value="1000"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLJ9"/>
    <dbReference type="KEGG" id="cgr:2890870"/>
    <dbReference type="CGD" id="CAL0135910">
        <property type="gene designation" value="CAGL0L02849g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02849g"/>
    <dbReference type="eggNOG" id="KOG0215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FLJ9"/>
    <dbReference type="OMA" id="LAYCSWC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
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            <begin position="44"/>
            <end position="419"/>
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            <begin position="190"/>
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            <begin position="445"/>
            <end position="508"/>
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            <begin position="543"/>
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            <begin position="672"/>
            <end position="1040"/>
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    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
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            <begin position="1042"/>
            <end position="1127"/>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU363031"/>
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            <dbReference type="Pfam" id="PF04560"/>
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        <source>
            <dbReference type="EMBL" id="CAG61865.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1133" mass="127450" checksum="69A484E10EDF8CEB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLL1</accession>
    <name>Q6FLL1_CANGA</name>
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        <recommendedName>
            <fullName evidence="11">Myb-like DNA-binding protein BAS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0L02585g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene designation" value="CAGL0L02585g"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02585g"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_021117_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLL1"/>
    <dbReference type="OMA" id="IHQHIHN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:snRNA-activating protein complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="Myb-like_DNA-bd"/>
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        <property type="entry name" value="Myb_dom"/>
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    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
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        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
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    </dbReference>
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        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="32"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="109"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="109"/>
            <end position="159"/>
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    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="162"/>
            <end position="212"/>
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    </feature>
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        <location>
            <begin position="170"/>
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    </feature>
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            <begin position="302"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="622"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="752"/>
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            <begin position="310"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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            <begin position="539"/>
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    </feature>
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            <begin position="569"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="86783" checksum="18C5E0460E0F692E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM09</accession>
    <name>Q6FM09_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0K11968g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM09"/>
    <dbReference type="FunCoup" id="Q6FM09">
        <property type="interactions" value="760"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM09"/>
    <dbReference type="KEGG" id="cgr:2889963"/>
    <dbReference type="CGD" id="CAL0134611">
        <property type="gene designation" value="CAGL0K11968g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11968g"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_22_0_1"/>
    <dbReference type="InParanoid" id="Q6FM09"/>
    <dbReference type="OMA" id="CIWNGYA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000080">
        <property type="entry name" value="3-hydroxyisobutyryl-CoA hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF3">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="4">
        <location>
            <begin position="44"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0134611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG61698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="495" mass="55714" checksum="1A92E80F0D45A023" modified="2004-07-19" version="1">MLRAPAAGFPRLIQKTSYRAFSSTLAKMSESETPVLFSVQETARIVTLNRPKKLNALNEEMCSSIFNTLTEYSKSDAANLILIKSNNSPRSLCAGGDVASVAQSNLDKNFESSINCFKSEYSLNFQLATYQKPVVVFMDGITMGGGVGLSIHTPFRIATENTKWAMPETDIGFFPDVGTTFALPRLITLANKNAQMALYLCLTGDVISGEDAYLLGLASHYIPHSNLEKLQTRLGELRPALDIKFFSDEFFDSVNLAIEEFTTPLPTNHKFKFSKDQLEVIEKCFDISSGESINAIFSKLEAFEGTPEMMQFARDTKKKLESKSMTSMQVGIRLMQENSRDDIESALKRDLTTAVNMCVNDSGIAEFSAATKHKLLDKQKVPYPWKQRTELTPQQVTSLIAPKPSLPVSLIRNNSNVTWSQYPHSLKYQLPRDYEIEQQVEKLIKRGPIKKNDVVKYFTDFNPQTKAKLGVEQYCDLLFDWKLSFDHASGLRWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM10</accession>
    <name>Q6FM10_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K11946g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448734.1">
        <property type="nucleotide sequence ID" value="XM_448734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM10"/>
    <dbReference type="STRING" id="284593.Q6FM10"/>
    <dbReference type="KEGG" id="cgr:2889962"/>
    <dbReference type="CGD" id="CAL0134755">
        <property type="gene designation" value="CAGL0K11946g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11946g"/>
    <dbReference type="HOGENOM" id="CLU_2209703_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM10"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="107" mass="11384" checksum="D5E4190C6F01EC4A" modified="2004-07-19" version="1">MGMGGMPNTGMNMMSQMQTGVQLGGTMPGTMQGRRRGGGSCNDCICCIELCGSCLTAWFAPSPMEVRQSATNNPIPNDRIAEANKPVPPPAYEPVLDNRTTVNHTHS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM46</accession>
    <name>COPB_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Beta-coat protein</fullName>
            <shortName evidence="1">Beta-COP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SEC26</name>
        <name type="ordered locus">CAGL0K11088g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPI-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448698.1">
        <property type="nucleotide sequence ID" value="XM_448698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM46"/>
    <dbReference type="SMR" id="Q6FM46"/>
    <dbReference type="FunCoup" id="Q6FM46">
        <property type="interactions" value="1368"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM46"/>
    <dbReference type="EnsemblFungi" id="CAGL0K11088g-T">
        <property type="protein sequence ID" value="CAGL0K11088g-T-p1"/>
        <property type="gene ID" value="CAGL0K11088g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890086"/>
    <dbReference type="KEGG" id="cgr:2890086"/>
    <dbReference type="CGD" id="CAL0134965">
        <property type="gene designation" value="CAGL0K11088g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11088g"/>
    <dbReference type="eggNOG" id="KOG1058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006949_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM46"/>
    <dbReference type="OMA" id="IYKNFDW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000430">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000408946" description="Coatomer subunit beta">
        <location>
            <begin position="1"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 1" evidence="2">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 2" evidence="2">
        <location>
            <begin position="133"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 3" evidence="2">
        <location>
            <begin position="317"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 4" evidence="2">
        <location>
            <begin position="397"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 5" evidence="2">
        <location>
            <begin position="481"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P41810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61661.1"/>
        </source>
    </evidence>
    <sequence length="972" mass="108446" checksum="1D98B14F165B1B79" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM65</accession>
    <name>Q6FM65_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="9">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0K10626g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="9"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM65"/>
    <dbReference type="FunCoup" id="Q6FM65">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM65"/>
    <dbReference type="CAZy" id="GT3">
        <property type="family name" value="Glycosyltransferase Family 3"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890101"/>
    <dbReference type="CGD" id="CAL0134357">
        <property type="gene designation" value="CAGL0K10626g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10626g"/>
    <dbReference type="eggNOG" id="KOG3742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015910_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FM65"/>
    <dbReference type="OMA" id="RDVRNHI"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000014">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0134357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="696" mass="79516" checksum="D44ED04556EF7C6B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM88</accession>
    <name>Q6FM88_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PDC2</name>
        <name evidence="4 5" type="ordered locus">CAGL0K10054g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
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                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
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                <person name="Weissenbach J."/>
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            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="project" value="CGD"/>
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        <property type="term" value="P:positive regulation of glycolytic fermentation to ethanol"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0000315"/>
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    </dbReference>
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        <property type="term" value="P:regulation of thiamine biosynthetic process"/>
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    </dbReference>
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        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN PDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DDE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="3">
        <location>
            <begin position="63"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0134375"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG61619.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="794" mass="91733" checksum="E48A12F40937C152" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM96</accession>
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        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
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    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="cgr:2890204"/>
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        <property type="gene designation" value="CAGL0K09878g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09878g"/>
    <dbReference type="eggNOG" id="ENOG502QT5E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022324_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM96"/>
    <dbReference type="OMA" id="IYIRCCK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="APP1"/>
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        <property type="entry name" value="APP1_cat"/>
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        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
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    </dbReference>
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    </dbReference>
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            <end position="382"/>
        </location>
    </feature>
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        <location>
            <begin position="448"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0134559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="630" mass="71764" checksum="68BCEB8FDC96FBF2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMC7</accession>
    <name>Q6FMC7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K09108g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMC7"/>
    <dbReference type="FunCoup" id="Q6FMC7">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMC7"/>
    <dbReference type="KEGG" id="cgr:2890248"/>
    <dbReference type="CGD" id="CAL0134899">
        <property type="gene designation" value="CAGL0K09108g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09108g"/>
    <dbReference type="eggNOG" id="ENOG502R07C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_416912_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMC7"/>
    <dbReference type="OMA" id="RETIWIN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="7">
        <location>
            <begin position="286"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="658" mass="77252" checksum="0730ECB34DD11A81" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FML9</accession>
    <name>SLX1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Structure-specific endonuclease subunit SLX1</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SLX1</name>
        <name type="ordered locus">CAGL0K06941g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLX1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448525.1">
        <property type="nucleotide sequence ID" value="XM_448525.1"/>
    </dbReference>
    <dbReference type="PDB" id="4XLG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.78 A"/>
        <property type="chains" value="A=1-312"/>
    </dbReference>
    <dbReference type="PDB" id="4XM5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.34 A"/>
        <property type="chains" value="A=1-312"/>
    </dbReference>
    <dbReference type="PDBsum" id="4XLG"/>
    <dbReference type="PDBsum" id="4XM5"/>
    <dbReference type="AlphaFoldDB" id="Q6FML9"/>
    <dbReference type="SMR" id="Q6FML9"/>
    <dbReference type="FunCoup" id="Q6FML9">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FML9"/>
    <dbReference type="EnsemblFungi" id="CAGL0K06941g-T">
        <property type="protein sequence ID" value="CAGL0K06941g-T-p1"/>
        <property type="gene ID" value="CAGL0K06941g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890413"/>
    <dbReference type="KEGG" id="cgr:2890413"/>
    <dbReference type="CGD" id="CAL0134685">
        <property type="gene designation" value="CAGL0K06941g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06941g"/>
    <dbReference type="eggNOG" id="KOG3005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030739_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FML9"/>
    <dbReference type="OMA" id="HNRGCDF"/>
    <dbReference type="EvolutionaryTrace" id="Q6FML9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="DisProt" id="DP04036"/>
    <dbReference type="FunFam" id="3.40.1440.10:FF:000006">
        <property type="entry name" value="Structure-specific endonuclease subunit SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000383780" description="Structure-specific endonuclease subunit SLX1">
        <location>
            <begin position="1"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="SLX1-type" evidence="1">
        <location>
            <begin position="219"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="25"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="33"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="59"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="121"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="129"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="135"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="160"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="220"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="234"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="239"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="253"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="271"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="280"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="2">
        <source>
            <dbReference type="PDB" id="4XLG"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="4XM5"/>
        </source>
    </evidence>
    <sequence length="312" mass="36433" checksum="5485DFD46860AD40" modified="2004-07-19" version="1">MEEFQQIPDFYGCYLLQSISKRQSFYIGSTPNPVRRLRQHNGSLSRGGAYRTKRDGTRPWEMVAIVYGFPSRIAALQFEHAWQHGYQTRYIKSQDRVVKTRKGGRSIHHKLAMITSLLKNEYFRYMDLTLHFFNQKVEEIWKNDKFNVSQTQESIDNNYTVSLSQDALTEINNDTIDDIMDVNEKNMELVQNLYSTTLAEKTKTLLLYKEKIDTGINTCQFCNKIIKHNLSGNISENLFAFCRDTSCTFVSHLACAYRYFMSNTELPKEDTIIPQSPKCPKCYTLLKWCDVIYYSIKLNKDNTTADDKKKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMP7</accession>
    <name>Q6FMP7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">HECT-type E3 ubiquitin transferase TOM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0K06303g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FMP7">
        <property type="interactions" value="1183"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMP7"/>
    <dbReference type="KEGG" id="cgr:2890462"/>
    <dbReference type="CGD" id="CAL0134355">
        <property type="gene designation" value="CAGL0K06303g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06303g"/>
    <dbReference type="eggNOG" id="KOG0939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000215_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FMP7"/>
    <dbReference type="OMA" id="DCHFSRE"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006997">
        <property type="term" value="P:nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="2911"/>
            <end position="3247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="925"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1875"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1942"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2025"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2251"/>
            <end position="2300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2404"/>
            <end position="2424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1876"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1904"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1958"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2031"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="2251"/>
            <end position="2263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2407"/>
            <end position="2424"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12">
        <location>
            <position position="3214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0134355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG61458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="3247" mass="371491" checksum="7CC236ABF8C2813E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN25</accession>
    <name>Q6FN25_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0K03333g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN25"/>
    <dbReference type="FunCoup" id="Q6FN25">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890170"/>
    <dbReference type="CGD" id="CAL0134637">
        <property type="gene designation" value="CAGL0K03333g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03333g"/>
    <dbReference type="eggNOG" id="ENOG502QTM3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014851_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FN25"/>
    <dbReference type="OMA" id="QDMQYWA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="9">
        <location>
            <begin position="485"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="533"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0134637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="602" mass="70350" checksum="F42657DC9D9DB97F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN37</accession>
    <name>Q6FN37_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0K03047g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN37"/>
    <dbReference type="FunCoup" id="Q6FN37">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN37"/>
    <dbReference type="KEGG" id="cgr:2890219"/>
    <dbReference type="CGD" id="CAL0134509">
        <property type="gene designation" value="CAGL0K03047g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03047g"/>
    <dbReference type="eggNOG" id="KOG0381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082854_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FN37"/>
    <dbReference type="OMA" id="PHSANEV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090139">
        <property type="term" value="P:mitochondrial chromosome packaging"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22012">
        <property type="entry name" value="HMG-box_ABF2_IXR1-like_rpt2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="55"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="128"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="55"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="128"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0134509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="201" mass="23087" checksum="F23DA10C58DBFA5D" modified="2004-07-19" version="1">MLALNLIRGVSRSAGVRFLQTSPIVWSKTAEGAKGKDKDAKSGVSRKDLIKQFGPKRPAAAFILYTVQERANATAENPGLSTKEISAVLGEKWRQLSEYEKEPYFQKTQQALEEYKTKKQEFEAMLPPKKPLSPFLLFSNEVREEIKSQNPSLSFGDLASLIGRRWKSLGEYEKKKYYDRYAENKSSWEQEVQRKLQNFKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN68</accession>
    <name>EAF3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EAF3</name>
        <name type="ordered locus">CAGL0K02321g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MRG family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448326.1">
        <property type="nucleotide sequence ID" value="XM_448326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN68"/>
    <dbReference type="SMR" id="Q6FN68"/>
    <dbReference type="FunCoup" id="Q6FN68">
        <property type="interactions" value="758"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN68"/>
    <dbReference type="EnsemblFungi" id="CAGL0K02321g-T">
        <property type="protein sequence ID" value="CAGL0K02321g-T-p1"/>
        <property type="gene ID" value="CAGL0K02321g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890303"/>
    <dbReference type="KEGG" id="cgr:2890303"/>
    <dbReference type="CGD" id="CAL0134779">
        <property type="gene designation" value="CAGL0K02321g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02321g"/>
    <dbReference type="eggNOG" id="KOG3001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039566_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FN68"/>
    <dbReference type="OMA" id="HKFFDIE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990453">
        <property type="term" value="C:nucleosome disassembly/reassembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140003">
        <property type="term" value="F:histone H3K36me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060195">
        <property type="term" value="P:negative regulation of antisense RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043487">
        <property type="term" value="P:regulation of RNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000088775" description="Chromatin modification-related protein EAF3">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor-knot" evidence="2">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="MRG" evidence="3">
        <location>
            <begin position="163"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="355" mass="40740" checksum="9166E03C6A955626" modified="2004-07-19" version="1">MFEVGGKCLAYHGPLLYEAKILRRWNPKLEKVEYSVPLKSGEEDGLPESMNREEFYYYIHYQGWKSSWDEWVSVDRIMELTEANIELKKQLVMEAKKASLAQQQKTKNGGSAKRGGGGAHSESNHGGRRSGSGDRRDSNAEERGIVPSEGPFRTSSVMSYNFSRNKLRIHIPMILESMLVDDWEIVTKEKKISNLPNPFPVETILDRFYKDVATRTTSPVELSLVEEYVYGLKQYFNEAIGNLLLYKLERLQYEQVFYPTPEQQQAMTPVERSLSGRRPGQLYGVLHLLRLISILPEMLSNCVGMDTQAINVILRHTEKLLLWLVDRIEDLLPHKVHKSYYTNTSSQYEGVALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FND1</accession>
    <name>Q6FND1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent kinase TDA10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0K00891g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GLYK kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FND1"/>
    <dbReference type="FunCoup" id="Q6FND1">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FND1"/>
    <dbReference type="KEGG" id="cgr:2890147"/>
    <dbReference type="CGD" id="CAL0134831">
        <property type="gene designation" value="CAGL0K00891g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00891g"/>
    <dbReference type="eggNOG" id="KOG2878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056986_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FND1"/>
    <dbReference type="OMA" id="FAGPQHF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001691">
        <property type="entry name" value="Probable ATP-dependent kinase TDA10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0134831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34511" checksum="1E03100AA754BB52" modified="2004-07-19" version="1">MADKLNSLEHCMKFVDEYVPAWFETGKRDPLFIFISGPQGSGKSYVGKRIYEHLKDYYKDQKSVAYASMDDFYLTHEAQQKLNKEYPNNKLLQGRGLPGTHDMALLYKCINAILQRHGNDNDSIDGDHLQDSSKLVLPKYDKSAFNGEGDRSTVTVSEKIPVDIFILEGWFLGFEPILQNFESEETVKGDMVDVNSKLFIYSDLLWDNPEIKSLGIVFAADQLENVYDWRLQQEKELIAKTGNGMNDEELKKFVDRYMPCYDLYYNHLIHTESLGSVATLTLGLDKERKVFSFKTRYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FND7</accession>
    <name>Q6FND7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger ZPR1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAGL0K00759g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448257.2">
        <property type="nucleotide sequence ID" value="XM_448257.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FND7"/>
    <dbReference type="FunCoup" id="Q6FND7">
        <property type="interactions" value="1086"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FND7"/>
    <dbReference type="KEGG" id="cgr:2890192"/>
    <dbReference type="eggNOG" id="KOG2703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024138_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FND7"/>
    <dbReference type="OMA" id="FREVVIM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="43"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="284"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="449"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="479" mass="54225" checksum="9EB0D5E00C6A5A46" modified="2004-07-19" version="1">MSEDKLFKPVGEAANEVQEENDNGVSLTGASDAMGHPVQEIESLCMNCEKNGVTRLLLTSIPYFREVVLMSFECPHCGFKNSEIQPASQIQEKGSKYQLKVESKEDFNRQVVKSETATCKFVELDVEIPAKRGQLTTVEGLLSEMIEDIEQDQEMRKSIDENLYNQIAEFIKKVRSYINCEPGTLPLTFILDDPSGNSWIEYKPGEPQHKWSHVQYVRSDEQNVVVGILTEDQYEQRRRAKLEELSNKGRNPSESVKVGSANAEFLSDATDIENFNNEVQTFRASCPSCTQECETHMKPVNIPHFKEVIIMSTTCEHCGYKSNEVKTGGSIPEKGRKITLLCDDPADLSRDILKSETCSLHIPELHLDIQEGTLGGRFTTLEGLLKQVYEELESRVFTQTSDSMDEATKQRWVDFFAKLKEALDGKVHFTVIMEDPLAGSYIQNVYAPDPDPNMKIEDYERTQQQNEDLGLNDMKTDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP11</accession>
    <name>Q6FP11_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0J07502g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448033.1">
        <property type="nucleotide sequence ID" value="XM_448033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP11"/>
    <dbReference type="STRING" id="284593.Q6FP11"/>
    <dbReference type="KEGG" id="cgr:2889596"/>
    <dbReference type="CGD" id="CAL0133230">
        <property type="gene designation" value="CAGL0J07502g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07502g"/>
    <dbReference type="eggNOG" id="KOG3378">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035143_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FP11"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01040">
        <property type="entry name" value="Mb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044399">
        <property type="entry name" value="Mb-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF6">
        <property type="entry name" value="ABL201WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="2">
        <location>
            <begin position="131"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="432" mass="49042" checksum="F89ADD2E43DEAF49" modified="2004-07-19" version="1">MMSSETSISFMKENSSNMSDSEKNKVLEDIIGESQSLVKGSSKKSTTSSSLMDPRMLKLELHLTEREIELIRDSWFIMLNDDLSPQTMAAFYGKLRQNKKISLTANLITNEKFNVMNQQYEENRKRLIKDKSIPYQISNTSTIEGSLFCAQFYENLIAMDQNVERMFPSIRHQAVSFSGVLNTAVDNLENIHVLDSYLRGIGKRHSRILGIKPAYFETMGKAFIRTFQDRFGIFFTIELEDIWSRLYSYLANGMIAFGVDPVLPQSIKSTRANSLDTLRTTSSGDASLRNSSFSKAQESDTSDFKTYMAQFNCDIVEEDDLDFPIPEILTTETSINENDNDVDDVKDMIKNFGFNMNKAEMTHKDSIQVKKTPLDSVNPKSSASSSKDNMSTASSISEKTRKKAVLQNKMKKKISAPIETPYKMSKRDCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP89</accession>
    <name>Q6FP89_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0J05742g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP89"/>
    <dbReference type="FunCoup" id="Q6FP89">
        <property type="interactions" value="750"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP89"/>
    <dbReference type="KEGG" id="cgr:2889804"/>
    <dbReference type="CGD" id="CAL0133288">
        <property type="gene designation" value="CAGL0J05742g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05742g"/>
    <dbReference type="eggNOG" id="KOG3206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067577_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FP89"/>
    <dbReference type="OMA" id="WCGIEFD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="4">
        <location>
            <begin position="187"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0133288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="253" mass="28989" checksum="0AA1E23D225271AE" modified="2004-07-19" version="1">MTSDKKIPVTVRLFNGQEPTKMYSDSITVSELREQIYAFSGVDPQDMKLYVAFNRTPMGRASSDERQWDLEVTKETNGDQRILEGHSSCYIIVQDTNKDSLIYQLMKQDEQDEGPLFEYSQKDYENRDNTVLRWKQQEQLGRFDSEYNANMAKDLEQQELKASQLQLGERCTVKGVSERRGWLRYVGPVEGLTGLWCGVEFDKAEGKNNGVFKEHTYFGPVSDNHGGFVRPQQVETGTQYAPFETSGSDSDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPA0</accession>
    <name>Q6FPA0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0J05500g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPA0"/>
    <dbReference type="SMR" id="Q6FPA0"/>
    <dbReference type="FunCoup" id="Q6FPA0">
        <property type="interactions" value="790"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPA0"/>
    <dbReference type="KEGG" id="cgr:2889483"/>
    <dbReference type="CGD" id="CAL0129479">
        <property type="gene designation" value="CAGL0J05500g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05500g"/>
    <dbReference type="eggNOG" id="KOG1978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FPA0"/>
    <dbReference type="OMA" id="SFNNVQY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032139">
        <property type="term" value="F:dinucleotide insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000404">
        <property type="term" value="F:heteroduplex DNA loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="215"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="710"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="421"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="542"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0129479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="907" mass="102996" checksum="762EA57336130EAF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPD7</accession>
    <name>Q6FPD7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0J04620g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPD7"/>
    <dbReference type="FunCoup" id="Q6FPD7">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPD7"/>
    <dbReference type="KEGG" id="cgr:2889448"/>
    <dbReference type="CGD" id="CAL0129781">
        <property type="gene designation" value="CAGL0J04620g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04620g"/>
    <dbReference type="eggNOG" id="KOG3037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115505_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPD7"/>
    <dbReference type="OMA" id="IPGETMW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="7">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="151" mass="17247" checksum="9871476983C6B9C0" modified="2004-07-19" version="1">MSEVVVRAGICEFDESSKLCDPLPVQGSIKMAPHEEGIELGFWSFEWSPVEKTAKPMEPISLILIPGETKCVRLSSKNGRVFSLVFSSDQKYFFWLQEKNAGSLKLDQFSENDLKFLEKLDSILKGPEEEEEEEAEDLTEKLKHEDVEMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPI9</accession>
    <name>Q6FPI9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Notchless protein homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome biogenesis factor RSA4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0J03476g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPI9"/>
    <dbReference type="FunCoup" id="Q6FPI9">
        <property type="interactions" value="830"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPI9"/>
    <dbReference type="KEGG" id="cgr:2889696"/>
    <dbReference type="CGD" id="CAL0133264">
        <property type="gene designation" value="CAGL0J03476g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03476g"/>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_16_1"/>
    <dbReference type="InParanoid" id="Q6FPI9"/>
    <dbReference type="OMA" id="AWEPYHR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110136">
        <property type="term" value="P:protein-RNA complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="10">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="184"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="227"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="400"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="442"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="484"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0133264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="517" mass="56970" checksum="91E2DEA27D856B35" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPM4</accession>
    <name>Q6FPM4_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">IRC5</name>
        <name evidence="12 13" type="ordered locus">CAGL0J02662g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447820.1">
        <property type="nucleotide sequence ID" value="XM_447820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPM4"/>
    <dbReference type="FunCoup" id="Q6FPM4">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPM4"/>
    <dbReference type="GeneID" id="2889751"/>
    <dbReference type="KEGG" id="cgr:2889751"/>
    <dbReference type="CGD" id="CAL0133166">
        <property type="gene designation" value="IRC5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02662g"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_17_3_1"/>
    <dbReference type="InParanoid" id="Q6FPM4"/>
    <dbReference type="OMA" id="WNICRID"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="231"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="599"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0133166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="844" mass="97392" checksum="D22CF16E20758548" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2022-08-03" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPN0</accession>
    <name>AWP1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adhesin AWP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">AWP1</name>
        <name evidence="9" type="ordered locus">CAGL0J02508g</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="journal article" date="2011" name="Mycopathologia" volume="172" first="415" last="427">
            <title>Identification and differential gene expression of adhesin-like wall proteins in Candida glabrata biofilms.</title>
            <authorList>
                <person name="Kraneveld E.A."/>
                <person name="de Soet J.J."/>
                <person name="Deng D.M."/>
                <person name="Dekker H.L."/>
                <person name="de Koster C.G."/>
                <person name="Klis F.M."/>
                <person name="Crielaard W."/>
                <person name="de Groot P.W."/>
            </authorList>
            <dbReference type="PubMed" id="21769633"/>
            <dbReference type="DOI" id="10.1007/s11046-011-9446-2"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="journal article" date="2021" name="PLoS Pathog." volume="17" first="e1009980" last="e1009980">
            <title>A novel class of Candida glabrata cell wall proteins with beta-helix fold mediates adhesion in clinical isolates.</title>
            <authorList>
                <person name="Reithofer V."/>
                <person name="Fernandez-Pereira J."/>
                <person name="Alvarado M."/>
                <person name="de Groot P."/>
                <person name="Essen L.O."/>
            </authorList>
            <dbReference type="PubMed" id="34962966"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1009980"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 18-324</scope>
        <scope>DISULFIDE BOND</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in cell adhesion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
        <text evidence="1">May be GPI-anchored.</text>
    </comment>
    <comment type="induction">
        <text evidence="5">Induced during biofilm formation.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447814.1">
        <property type="nucleotide sequence ID" value="XM_447814.1"/>
    </dbReference>
    <dbReference type="PDB" id="7O9Q">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="A=18-324"/>
    </dbReference>
    <dbReference type="PDBsum" id="7O9Q"/>
    <dbReference type="AlphaFoldDB" id="Q6FPN0"/>
    <dbReference type="SMR" id="Q6FPN0"/>
    <dbReference type="STRING" id="284593.Q6FPN0"/>
    <dbReference type="GlyCosmos" id="Q6FPN0">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0J02508g-T">
        <property type="protein sequence ID" value="CAGL0J02508g-T-p1"/>
        <property type="gene ID" value="CAGL0J02508g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889767"/>
    <dbReference type="KEGG" id="cgr:2889767"/>
    <dbReference type="CGD" id="CAL0133080">
        <property type="gene designation" value="AWP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02508g"/>
    <dbReference type="eggNOG" id="KOG3544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_369178_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPN0"/>
    <dbReference type="OMA" id="GLXRRDD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098631">
        <property type="term" value="F:cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword id="KW-0002">3D-structure</keyword>
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    <keyword id="KW-0964">Secreted</keyword>
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            <dbReference type="PDB" id="7O9Q"/>
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    <sequence length="870" mass="84312" checksum="6BC9C0FC36C0EB4E" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPQ4</accession>
    <name>AIM21_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM21</name>
        <name type="ordered locus">CAGL0J01958g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <text evidence="1">Involved in mitochondrial migration along actin filaments.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
        <text evidence="1">Cortical actin patches.</text>
    </comment>
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        <text evidence="3">Belongs to the AIM21 family.</text>
    </comment>
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        <property type="component" value="Chromosome J"/>
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    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="Pfam" id="PF11489">
        <property type="entry name" value="Aim21"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000305" key="3"/>
    <sequence length="701" mass="77561" checksum="6F57EEC37694D561" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPQ8</accession>
    <name>Q6FPQ8_CANGA</name>
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        <recommendedName>
            <fullName evidence="14">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0J01870g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 14">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="14"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447786.1">
        <property type="nucleotide sequence ID" value="XM_447786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPQ8"/>
    <dbReference type="STRING" id="284593.Q6FPQ8"/>
    <dbReference type="KEGG" id="cgr:2889811"/>
    <dbReference type="CGD" id="CAL0132988">
        <property type="gene designation" value="CAGL0J01870g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01870g"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FPQ8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000008">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006413">
        <property type="entry name" value="P-type_ATPase_IIA_PMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01522">
        <property type="entry name" value="ATPase-IIA2_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 14" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="841"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="879"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="906"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="15">
        <location>
            <begin position="47"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0132988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG60735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="946" mass="104255" checksum="623BEDD9A1BD930A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPR9</accession>
    <name>Q6FPR9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell wall protein CWP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J01463g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447775.1">
        <property type="nucleotide sequence ID" value="XM_447775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPR9"/>
    <dbReference type="KEGG" id="cgr:2889844"/>
    <dbReference type="CGD" id="CAL0133730">
        <property type="gene designation" value="CAGL0J01463g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01463g"/>
    <dbReference type="eggNOG" id="ENOG502S09G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054077_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPR9"/>
    <dbReference type="OMA" id="MADSQTF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000420">
        <property type="entry name" value="Yeast_PIR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00399">
        <property type="entry name" value="PIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00929">
        <property type="entry name" value="PIR_REPEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50256">
        <property type="entry name" value="PIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274139" description="Cell wall protein CWP1" evidence="3">
        <location>
            <begin position="21"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0133730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="25514" checksum="1E297763C1ABA89C" modified="2004-07-19" version="1">MKFTHQFVLSLIALAKLVMADSQQFGIISIASGSDLQYASAFFDSNNLVVGHQPNNQFALVVTDDGKLKSTSGNQFIAVDANSGNLKEVSDSNSASVGFSIKNGHLLYLNSESFYAVPGASSGATWSLSTKNTNSAQGAAASPVVLRTQSTTGTDVVADFTPAAMSSVSSVVPSSISSVHPSSLVSSGSTLVLSKASGSAVPISQIGDGQIQATATSHVPPVQSHNGAIGQHGPYLGMHAGVAAAAIAYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ12</accession>
    <name>Q6FQ12_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein BTN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I10010g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ12"/>
    <dbReference type="FunCoup" id="Q6FQ12">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ12"/>
    <dbReference type="KEGG" id="cgr:2889281"/>
    <dbReference type="CGD" id="CAL0129756">
        <property type="gene designation" value="CAGL0I10010g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I10010g"/>
    <dbReference type="eggNOG" id="ENOG502S308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055876_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ12"/>
    <dbReference type="OMA" id="ETHIEWH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034504">
        <property type="term" value="P:protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="39201" checksum="67E568AA4E645E2B" modified="2004-07-19" version="1">MLDIFNGPCMATLPSIYNNDAAFPHDIFSAMPIFSDMMVDAPHGKRRCYKNYNKTGGNEHTQKHASRARSHKKQHSMNYKIEKLGNGNYELQLSKKIGHNVVAKAINDQVSVLAEKYYVPSYSVVRDIFGRQYYVEEETDEEELRQKVMSQIDIGDIKRKIARQQFNDYEFELNHRGDEVIMFSKSDKIEKEFNFGENLEDIRMKYCTINNKNTEAVLCVELIASEGHNINNSVFAQPVNHANEVFPDPRSDLSHQSSEEENEEDEAYISTDDELNTNTDGNTSDSSDVVSDAVSDSDSSAYYGESVTKVYSPILENVEDEEIDRYRKSFEHSPSGYAIIEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQD6</accession>
    <name>Q6FQD6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar morphogenesis protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0I07095g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQD6"/>
    <dbReference type="FunCoup" id="Q6FQD6">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQD6"/>
    <dbReference type="KEGG" id="cgr:2889186"/>
    <dbReference type="CGD" id="CAL0132462">
        <property type="gene designation" value="CAGL0I07095g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07095g"/>
    <dbReference type="eggNOG" id="KOG3202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033748_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQD6"/>
    <dbReference type="OMA" id="DSFDTRW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061909">
        <property type="term" value="P:autophagosome-lysosome fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007036">
        <property type="term" value="P:vacuolar calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15858">
        <property type="entry name" value="SNARE_VAM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000058">
        <property type="entry name" value="VAM7p Vacuolar SNARE protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="261"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="264"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0132462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="326" mass="38461" checksum="A5C102F43932FCFD" modified="2004-07-19" version="1">MASKGYARMRVRYRVHVDEVQVRGGVAKYGLVVSVWDQDGQEELRETTVWRRYSEFLALKKELESSCGCDIPYEFPPRTLWFGGGSKTGGTDKKVIEERKVKLADFMSELLNDSFDVKWKRHKSVSNFLGMDIAQMENVKSTKSKPPQNGWMDMFHEYKMEFEDCKKQEGVQRSRNAMYIRLKLNELEQILNTEELPEEERDRRSKLLTTLKQDLNELTISREDPIVPREQVVKPLPGRRMLGETIETAKYNNRDLLQVQKQMNKEQDQELEQLHKIIQRQKQLSMEMNEELSQQNELLDSFQNDVDRTAMKLKQANRRARDFNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQJ8</accession>
    <name>Q6FQJ8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0I05676g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQJ8"/>
    <dbReference type="SMR" id="Q6FQJ8"/>
    <dbReference type="FunCoup" id="Q6FQJ8">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQJ8"/>
    <dbReference type="KEGG" id="cgr:2889341"/>
    <dbReference type="CGD" id="CAL0132236">
        <property type="gene designation" value="CAGL0I05676g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05676g"/>
    <dbReference type="eggNOG" id="KOG0923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_11_1"/>
    <dbReference type="InParanoid" id="Q6FQJ8"/>
    <dbReference type="OMA" id="PLDPMMS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="134"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="325"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0132236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG60433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="758" mass="85775" checksum="67BBD86E7143CFA5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQR7</accession>
    <name>SHE10_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Outer spore wall assembly protein SHE10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sensitivity to high expression protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SHE10</name>
        <name type="ordered locus">CAGL0I04092g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in spore wall assembly. May be a component of the mitochondrial RNase MRP (MtMRP), a ribonucleoprotein endoribonuclease involved in the cleaving RNA transcripts to generate primers for DNA replication in mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondria-localized RNase mitochondrial RNA-processing (RNase MRP) composed of one single RNA encoded by the NME1 gene and at least 31 proteins. Absent in the nucleus-localized RNase MRP (NuMRP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SHE10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447427.1">
        <property type="nucleotide sequence ID" value="XM_447427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQR7"/>
    <dbReference type="SMR" id="Q6FQR7"/>
    <dbReference type="FunCoup" id="Q6FQR7">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQR7"/>
    <dbReference type="EnsemblFungi" id="CAGL0I04092g-T">
        <property type="protein sequence ID" value="CAGL0I04092g-T-p1"/>
        <property type="gene ID" value="CAGL0I04092g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889099"/>
    <dbReference type="KEGG" id="cgr:2889099"/>
    <dbReference type="CGD" id="CAL0132508">
        <property type="gene designation" value="CAGL0I04092g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04092g"/>
    <dbReference type="eggNOG" id="ENOG502QT2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023952_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQR7"/>
    <dbReference type="OMA" id="MINEWSK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000408907" description="Outer spore wall assembly protein SHE10">
        <location>
            <begin position="22"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="190"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="135"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="481"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="556" mass="64520" checksum="8D090F23C9935C0D" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQX8</accession>
    <name>Q6FQX8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">YKU70</name>
        <name evidence="20 21" type="ordered locus">CAGL0I02662g</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447366.1">
        <property type="nucleotide sequence ID" value="XM_447366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQX8"/>
    <dbReference type="FunCoup" id="Q6FQX8">
        <property type="interactions" value="727"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQX8"/>
    <dbReference type="GeneID" id="2889390"/>
    <dbReference type="KEGG" id="cgr:2889390"/>
    <dbReference type="CGD" id="CAL0130470">
        <property type="gene designation" value="YKU70"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02662g"/>
    <dbReference type="eggNOG" id="KOG2327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024202_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQX8"/>
    <dbReference type="OMA" id="FWANVKH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097695">
        <property type="term" value="P:establishment of protein-containing complex localization to telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="19">
        <location>
            <begin position="332"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0130470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG60303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="606" mass="70955" checksum="6F4A76A6BA84737F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR04</accession>
    <name>Q6FR04_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I02046g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447340.1">
        <property type="nucleotide sequence ID" value="XM_447340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR04"/>
    <dbReference type="FunCoup" id="Q6FR04">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR04"/>
    <dbReference type="KEGG" id="cgr:2888953"/>
    <dbReference type="CGD" id="CAL0132572">
        <property type="gene designation" value="CAGL0I02046g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02046g"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FR04"/>
    <dbReference type="OMA" id="IDLYQPC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="349" mass="39228" checksum="AA83CFAB525A39C4" modified="2004-07-19" version="1">MTTKDKIATIRKEIEKIGTGYGMMTLTNLAVPTERTQAFGAINKVIEIARAQGHKAFFNVGEFYGPNYANLHLVRDFFKEYPNLREYVLISCKGAIDNKKLTPKGKYEEVVASMETCIKEIGVFIDIFEPARLDFNLCKEHDVYPKETLQAVADFVDAGKFGAISLSEVNGEQINAISKDFGDYLVCVEIELSMFRDTILKNGTAKACSDNALPIICYSPLGRGILTGQITKNSDIPDGDFRKKLKYFSDEALAHNQEIVNFIKSEIVEKRPDEKRVTLAQVALAWVRKWSYSSEYPKSKFIPIPSGSSATRVSENFEESKTQLSDTEFEKINEYVNSFSPIGGSYEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR86</accession>
    <name>Q6FR86_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0H10582g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR86"/>
    <dbReference type="FunCoup" id="Q6FR86">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR86"/>
    <dbReference type="MEROPS" id="C19.002"/>
    <dbReference type="KEGG" id="cgr:2888756"/>
    <dbReference type="CGD" id="CAL0130534">
        <property type="gene designation" value="CAGL0H10582g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10582g"/>
    <dbReference type="eggNOG" id="KOG1867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_6_1_1"/>
    <dbReference type="InParanoid" id="Q6FR86"/>
    <dbReference type="OMA" id="VECNRCA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="96"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="143"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="615"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="765"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="577"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="623"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0130534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="790" mass="89847" checksum="B5C47EFAF63C9CA9" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRE3</accession>
    <name>Q6FRE3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-1,3-mannosyltransferase MNT3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0H09240g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447201.1">
        <property type="nucleotide sequence ID" value="XM_447201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRE3"/>
    <dbReference type="FunCoup" id="Q6FRE3">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="CAZy" id="GT71">
        <property type="family name" value="Glycosyltransferase Family 71"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888721"/>
    <dbReference type="CGD" id="CAL0131624">
        <property type="gene designation" value="CAGL0H09240g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09240g"/>
    <dbReference type="eggNOG" id="ENOG502RZ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015387_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FRE3"/>
    <dbReference type="OMA" id="VYGACYL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0131624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="75074" checksum="69AF549DE4928492" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-29" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRG0</accession>
    <name>HOT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>High-osmolarity-induced transcription protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HOT1</name>
        <name type="ordered locus">CAGL0H08866g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for a complete transcriptional response to osmotic stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447184.1">
        <property type="nucleotide sequence ID" value="XM_447184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRG0"/>
    <dbReference type="SMR" id="Q6FRG0"/>
    <dbReference type="FunCoup" id="Q6FRG0">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRG0"/>
    <dbReference type="EnsemblFungi" id="CAGL0H08866g-T">
        <property type="protein sequence ID" value="CAGL0H08866g-T-p1"/>
        <property type="gene ID" value="CAGL0H08866g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888634"/>
    <dbReference type="KEGG" id="cgr:2888634"/>
    <dbReference type="CGD" id="CAL0131714">
        <property type="gene designation" value="CAGL0H08866g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08866g"/>
    <dbReference type="eggNOG" id="ENOG502QQ7G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023418_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRG0"/>
    <dbReference type="OMA" id="KTIWEEY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF2">
        <property type="entry name" value="HIGH-OSMOLARITY-INDUCED TRANSCRIPTION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000289669" description="High-osmolarity-induced transcription protein 1">
        <location>
            <begin position="1"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="658" mass="73097" checksum="9D4A64481B044DBA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRG5</accession>
    <name>Q6FRG5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H08756g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447179.1">
        <property type="nucleotide sequence ID" value="XM_447179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRG5"/>
    <dbReference type="KEGG" id="cgr:2888760"/>
    <dbReference type="CGD" id="CAL0131760">
        <property type="gene designation" value="CAGL0H08756g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08756g"/>
    <dbReference type="HOGENOM" id="CLU_2558076_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRG5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0131760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="82" mass="9430" checksum="52EE0B050B455224" modified="2004-07-19" version="1">MRGKAISEDQRVCTGVSERMYALNKSRGPLLPTSHKHKHKHKYKYKHNSCENLRRGTDFGSTLRAAFRLWGLRRAISAESSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRT3</accession>
    <name>TIM9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial import inner membrane translocase subunit TIM9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TIM9</name>
        <name type="ordered locus">CAGL0H06127g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447061.1">
        <property type="nucleotide sequence ID" value="XM_447061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRT3"/>
    <dbReference type="SMR" id="Q6FRT3"/>
    <dbReference type="FunCoup" id="Q6FRT3">
        <property type="interactions" value="960"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRT3"/>
    <dbReference type="EnsemblFungi" id="CAGL0H06127g-T">
        <property type="protein sequence ID" value="CAGL0H06127g-T-p1"/>
        <property type="gene ID" value="CAGL0H06127g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888851"/>
    <dbReference type="KEGG" id="cgr:2888851"/>
    <dbReference type="CGD" id="CAL0130367">
        <property type="gene designation" value="CAGL0H06127g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H06127g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06127g"/>
    <dbReference type="eggNOG" id="KOG3479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FRT3"/>
    <dbReference type="OMA" id="QDFLRMY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000008">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000228042" description="Mitochondrial import inner membrane translocase subunit TIM9">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Twin CX3C motif">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="87" mass="10128" checksum="2E3C5AC8ABD5DC24" modified="2004-07-19" version="1">MDQLNAKEQQEFQKLVEQKQMKDFMRLYSGLVERCFTDCVNDFTSSKLTSKEESCILKCSEKFLKHSERVGQRFQEQNAALGQGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS79</accession>
    <name>Q6FS79_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein Dnt1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0H02783g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FS79">
        <property type="interactions" value="818"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS79"/>
    <dbReference type="KEGG" id="cgr:2888884"/>
    <dbReference type="CGD" id="CAL0131970">
        <property type="gene designation" value="CAGL0H02783g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02783g"/>
    <dbReference type="eggNOG" id="ENOG502QW4V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238481_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS79"/>
    <dbReference type="OMA" id="WNERELA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018844">
        <property type="entry name" value="Dnt1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043185">
        <property type="entry name" value="Net1/Tof2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28196">
        <property type="entry name" value="NUCLEOLAR PROTEIN NET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28196:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN NET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10407">
        <property type="entry name" value="Cytokin_check_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein Dnt1-like N-terminal" evidence="2">
        <location>
            <begin position="82"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
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    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0130781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="63" mass="7094" checksum="1350571D8D9D02CF" modified="2004-07-19" version="1">MAKVHGSLARAGKVKSQTPKVEKSEKPKKPKGRAYKRLLYTRRFVNVTLTNGKRRMNPGPSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSN2</accession>
    <name>Q6FSN2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FMR1-interacting protein 1 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G09218g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSN2"/>
    <dbReference type="FunCoup" id="Q6FSN2">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSN2"/>
    <dbReference type="KEGG" id="cgr:2888047"/>
    <dbReference type="CGD" id="CAL0129466">
        <property type="gene designation" value="CAGL0G09218g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09218g"/>
    <dbReference type="eggNOG" id="ENOG502S1E3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038609_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSN2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMR1-interacting protein 1 conserved" evidence="2">
        <location>
            <begin position="199"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="379" mass="43792" checksum="6DF34DD1432744E4" modified="2004-07-19" version="1">MNYDDEDDDSYDPYNALPKPTFSGVIGDDTAHVNKKPRIQENYAPIQNISNTYAYNTGNMMMTGYPYPPVYQQPQGVYMATNNQWDNRYPMTWQQYMPAQSNSISMHTPDINYTNYHTPQPVAPYISENSRGFLERQDPDKTSTSNSIVKSEDLVRGKNTSEIPDKHKPVKLANNKDRDKTGNKDDDDDELSIPKSEEGAKVLIPGTSISLETEEDIKKWKDERRKMWLLRISNNKKEHMEKMGYKDEDLKKETNVLKESRKDKNFIKNIQSQISRANPNVNLNTRLVQRGMAEENAKLLDFIVELGECGFLEYELTEEEKEKLFGGYSNNFSNNRKNYHGRRNNNNSNEKREYNGASRYNNGKNSTVVQDVSGKQENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FST8</accession>
    <name>Q6FST8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Arp2/3 complex 34 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0G07909g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ARPC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FST8"/>
    <dbReference type="FunCoup" id="Q6FST8">
        <property type="interactions" value="813"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FST8"/>
    <dbReference type="KEGG" id="cgr:2888321"/>
    <dbReference type="CGD" id="CAL0137587">
        <property type="gene designation" value="CAGL0G07909g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07909g"/>
    <dbReference type="eggNOG" id="KOG2826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059439_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FST8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072697">
        <property type="term" value="P:protein localization to cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000009">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000010">
        <property type="entry name" value="Arp2/3 complex 34 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007188">
        <property type="entry name" value="ARPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12058">
        <property type="entry name" value="ARP2/3 COMPLEX 34 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04045">
        <property type="entry name" value="P34-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="323" mass="37251" checksum="0E1758DC257AEAA1" modified="2004-07-19" version="1">MLHLQPANLLIQKTLFEALDANAKGTPLTLDRIISDFDYTTFHVSNTPDNKSILLLSVRTKAWQSILQGGDLLTFLQGKYANTQGVSVANAVEPGFDYTLQIDIGSLNEEAIKRCSILKTLVLSFPFHQAFEEFHQLNNQPIPEGSVVESQNVHVIKYRDDENIFVKAASDRVTVIFETIFQDETDKILGKVFLQEFVDARKRNRGIQSAPQVLFSHEPPLEIQSVAQNQNTQGKHDSRRFITFVLFPRHFQTEELQFTSVSQLTLFRNYFHYHIKCSKAYMHSRMRYRVDTFVKVLNRAKVDEEDDNEDSNRRTITGRKMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT33</accession>
    <name>Q6FT33_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0G05742g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT33"/>
    <dbReference type="FunCoup" id="Q6FT33">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT33"/>
    <dbReference type="KEGG" id="cgr:2888001"/>
    <dbReference type="CGD" id="CAL0130025">
        <property type="gene designation" value="CAGL0G05742g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05742g"/>
    <dbReference type="eggNOG" id="ENOG502QVC2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037639_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FT33"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000573">
        <property type="entry name" value="Nop6p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="71"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0130025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="208" mass="23740" checksum="FA662860FC62AB10" modified="2004-07-19" version="1">MAEEGKVGEKKLSKKQLKAQQFRKSKEEKTTDAKRKIEEEEKKEEEQPKKKRKTRRGKKGKGNKNASGNRFIVFVGGLPKDITASELQVHFKSSGPDVIRLRAEKGIAFLEFDGDKDKTGIQRRMDVALLQNKTMLKDRRINVELTVGGGGNSQDRLEKLRKKNEKFEAERQERMAKFINKSTPKDKKSDSDTTTTTGIHPDRAKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTP4</accession>
    <name>Q6FTP4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0G00902g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTP4"/>
    <dbReference type="FunCoup" id="Q6FTP4">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTP4"/>
    <dbReference type="KEGG" id="cgr:2888212"/>
    <dbReference type="CGD" id="CAL0130681">
        <property type="gene designation" value="CAGL0G00902g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00902g"/>
    <dbReference type="eggNOG" id="KOG0864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018357_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTP4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061676">
        <property type="term" value="F:importin-alpha family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031990">
        <property type="term" value="P:mRNA export from nucleus in response to heat stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053074">
        <property type="entry name" value="NPC_Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015007">
        <property type="entry name" value="NUP2/50/61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38697:SF1">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SIMILAR TO S. CEREVISIAE NUP2 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08911">
        <property type="entry name" value="NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="583"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="416"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="519"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="566"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0130681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="722" mass="78484" checksum="CE602CAA7C5ABD4C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTW4</accession>
    <name>Q6FTW4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial carrier protein MTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0F08305g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTW4"/>
    <dbReference type="FunCoup" id="Q6FTW4">
        <property type="interactions" value="887"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTW4"/>
    <dbReference type="KEGG" id="cgr:2887588"/>
    <dbReference type="CGD" id="CAL0131038">
        <property type="gene designation" value="CAGL0F08305g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08305g"/>
    <dbReference type="eggNOG" id="KOG0761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTW4"/>
    <dbReference type="OMA" id="YWWGYES"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031921">
        <property type="term" value="P:pyridoxal phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="164"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="275"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0131038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="41931" checksum="B70486C23B662E83" modified="2004-07-19" version="1">MTDRPPATLTIQERMMSATVGSLLTSVILTPMDVVRIRLQQQQMLADCGCADISELDDSKVRKRISEGGVRRNTLEQLRQSKVVNRIDTVPKIFWESTCFQNLNCRNQKFNGTLEAFEKIAKFEGVTTLWRGISITLLMAIPANVVYFTGYEYVRDRSPLNGLYPTINPLICGAFARTLAATSVAPLELIKTKLQSIPSSSMKNGSVIMYRDLFNEIKSEIAMRGVAQTMFKGLEITLWRDVPFSAIYWASYEFYKTKVAYLSPSTFDKNSSNWFHFTNSFLGGFISGSLAAICTHPFDVGKTRQQISLVTDKKLANSNLKYGSSNTMFGFLNYIRKTEGIGALYTGLAPRVAKIAPSCAIMISSYELTKRLFM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTZ5</accession>
    <name>MTC2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Maintenance of telomere capping protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MTC2</name>
        <name type="ordered locus">CAGL0F07623g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in telomere capping.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MTC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446299.1">
        <property type="nucleotide sequence ID" value="XM_446299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTZ5"/>
    <dbReference type="FunCoup" id="Q6FTZ5">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTZ5"/>
    <dbReference type="EnsemblFungi" id="CAGL0F07623g-T">
        <property type="protein sequence ID" value="CAGL0F07623g-T-p1"/>
        <property type="gene ID" value="CAGL0F07623g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887678"/>
    <dbReference type="KEGG" id="cgr:2887678"/>
    <dbReference type="CGD" id="CAL0131288">
        <property type="gene designation" value="CAGL0F07623g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07623g"/>
    <dbReference type="eggNOG" id="ENOG502QQMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060779_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTZ5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000407761" description="Maintenance of telomere capping protein 2">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="418" mass="48384" checksum="D35A4A1A5BFBB6DB" modified="2004-07-19" version="1">MTEMDFDLEQIQKYELPDFETALLFSIVAKKNFLVLFDAEQRKLNDEISNEELIQKSVGDVMQKRTDFKINFKYQCINHVTDEMISEIQKCELDDYKNLETMEHVDEKGDRSANIAGVDQNVTIEFYLVEDIDRQSLADYYQLGRLMREGYIFNVQHNGIANNKKYWKLFIGTVAWKRDEYIIPDDILQLGAADKKYSHKHGQSFKLKSFSTGFEDWIRHKFWLVTTLAMPNIKPTIEVQAADDTASFSSVVITKDEAKEEEAITGSSDGAEKIISGDYKNYDNIHIQASLRRYILDIMVHIRTHRLTFNARGGGIHKNCYSNMITLSKIICIKDHKSFVVPQHVRLAAMWFLPLQLSVIDDSLKDNSILYGSKPELVRELMKRVVYVRNKQIIDMDNPLFMEALIVKSALKKIVPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU62</accession>
    <name>Q6FU62_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MSN2</name>
        <name evidence="14 15" type="ordered locus">CAGL0F05995g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446232.1">
        <property type="nucleotide sequence ID" value="XM_446232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU62"/>
    <dbReference type="SMR" id="Q6FU62"/>
    <dbReference type="FunCoup" id="Q6FU62">
        <property type="interactions" value="2469"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU62"/>
    <dbReference type="GeneID" id="2887591"/>
    <dbReference type="KEGG" id="cgr:2887591"/>
    <dbReference type="CGD" id="CAL0131140">
        <property type="gene designation" value="MSN2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05995g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457076_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU62"/>
    <dbReference type="OMA" id="PHQHATS"/>
    <dbReference type="PHI-base" id="PHI:9718"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004307">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001156">
        <property type="entry name" value="Zinc finger protein 407"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0131140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG59156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="597" mass="66305" checksum="A4BA43789C962D88" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUD7</accession>
    <name>Q6FUD7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RIB1</name>
        <name evidence="10 11" type="ordered locus">CAGL0F04279g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446157.1">
        <property type="nucleotide sequence ID" value="XM_446157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUD7"/>
    <dbReference type="FunCoup" id="Q6FUD7">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUD7"/>
    <dbReference type="GeneID" id="2887883"/>
    <dbReference type="KEGG" id="cgr:2887883"/>
    <dbReference type="CGD" id="CAL0130922">
        <property type="gene designation" value="RIB1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04279g"/>
    <dbReference type="eggNOG" id="KOG1284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020273_2_4_1"/>
    <dbReference type="InParanoid" id="Q6FUD7"/>
    <dbReference type="OMA" id="RLPNVEC"/>
    <dbReference type="PHI-base" id="PHI:12190"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="9">
        <location>
            <begin position="105"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0130922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="295" mass="33410" checksum="B5B12D123BE735A9" modified="2004-07-19" version="1">MSLPVVQCIARARIPTTHGPDIFLHLYTNDRDNKEHLAIVFGEDIRSRTLFRQYPGETQQDRMVRGAYVGKLYPGRTVADVDERLGFRLEFDAEGNLLTNSATTWSEENDTLVRIHSECYTGETAWSARCDCGEQFDRAGKLISLDEEPETHIKGGCGHGVIVYLRQEGRGIGLSEKLKAYNLQDLGADTVQANLMLKHPADARDFGIGRAILIDLGIKNVRLLTNNPDKIQQVSYKDQLRCVERVPMIPIHWTDESKGIDSKEIEGYLRTKIERMGHLLQKPLNLHTPQEQETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUI8</accession>
    <name>Q6FUI8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0F03135g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUI8"/>
    <dbReference type="FunCoup" id="Q6FUI8">
        <property type="interactions" value="1459"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUI8"/>
    <dbReference type="KEGG" id="cgr:2887787"/>
    <dbReference type="CGD" id="CAL0131422">
        <property type="gene designation" value="CAGL0F03135g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03135g"/>
    <dbReference type="eggNOG" id="KOG2908">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042989_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUI8"/>
    <dbReference type="OMA" id="SFEDYWE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="186"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0131422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="395" mass="46330" checksum="D740B26960A81759" modified="2004-07-19" version="1">MVGHEVDTILSTLRIEADPELSYLFDKFEHDYENKLWHQLTQNLNVFFMDERSKPLRLRIYDTFIVKFQENINELSLVQYLLVALQTISDSDEALKYLTHLKQTLEDIDSKKTRNDGLNNHDNAFLFIDIEIARLYLHKKELLKARDMLDVLEKTLDFKDNVPLLLTSSFYSANAEYYKLKEDFSSFYYTSLLYLSTLEDDNELTIINKEPSFELAYDLCVAALLGEKIYNFGELLQHPIMNLINERKDYHWIADLLNALTVGDLEKFDKLISVQMPKTLILAQNETFLRQKIRLMSLVECIFAKNIRLLSFQDVADATQIEKDQVEHLVIKAISLKLLKGSIDQVNELVTVTWVQPRIINEEQILKMKNRLVDWDEQVRALAVRLEERGKPIWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUN1</accession>
    <name>Q6FUN1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0F02079g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUN1"/>
    <dbReference type="FunCoup" id="Q6FUN1">
        <property type="interactions" value="845"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUN1"/>
    <dbReference type="KEGG" id="cgr:2887737"/>
    <dbReference type="CGD" id="CAL0131032">
        <property type="gene designation" value="CAGL0F02079g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02079g"/>
    <dbReference type="eggNOG" id="KOG0018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FUN1"/>
    <dbReference type="OMA" id="KHMDFQR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003680">
        <property type="term" value="F:minor groove of adenine-thymine-rich DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="12">
        <location>
            <begin position="525"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="251"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="405"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="729"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="809"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0131032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG58987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1223" mass="140433" checksum="F40BDB3F398BDC8E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUP5</accession>
    <name>Q6FUP5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="6">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0F01771g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUP5"/>
    <dbReference type="FunCoup" id="Q6FUP5">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUP5"/>
    <dbReference type="CAZy" id="GH47">
        <property type="family name" value="Glycoside Hydrolase Family 47"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887950"/>
    <dbReference type="CGD" id="CAL0131050">
        <property type="gene designation" value="CAGL0F01771g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01771g"/>
    <dbReference type="eggNOG" id="KOG2204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022261_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUP5"/>
    <dbReference type="OMA" id="YYTFENE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0131050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="807" mass="92850" checksum="6EBDA2E29E32DB71" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-10-25" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUY5</accession>
    <name>VATL2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V-type proton ATPase subunit c'</fullName>
            <shortName evidence="1">V-ATPase subunit c'</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Proteolipid protein VMA11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>V-type proton ATPase 16 kDa proteolipid subunit 2</fullName>
            <shortName>V-ATPase 16 kDa proteolipid subunit 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Vacuolar proton pump 16 kDa proteolipid subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Vacuolar proton pump c' subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">VMA11</name>
        <name type="ordered locus">CAGL0E06204g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (By similarity). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445959.1">
        <property type="nucleotide sequence ID" value="XM_445959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUY5"/>
    <dbReference type="SMR" id="Q6FUY5"/>
    <dbReference type="FunCoup" id="Q6FUY5">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUY5"/>
    <dbReference type="EnsemblFungi" id="CAGL0E06204g-T">
        <property type="protein sequence ID" value="CAGL0E06204g-T-p1"/>
        <property type="gene ID" value="CAGL0E06204g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887351"/>
    <dbReference type="KEGG" id="cgr:2887351"/>
    <dbReference type="CGD" id="CAL0128810">
        <property type="gene designation" value="CAGL0E06204g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_E06204g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06204g"/>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085752_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FUY5"/>
    <dbReference type="OMA" id="MSVCPPY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000071783" description="V-type proton ATPase subunit c'">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="158"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="site" description="Essential for proton translocation" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="164" mass="17093" checksum="4AE7668074EB2F76" modified="2004-07-19" version="1">MDMVASDNVYAPLYAPFFGFAGCALAMILSCLGAAIGTAKSGIGIAGIGTFKPELIMKSLIPVVMSGILAIYGLVVAVLIAGNLSPTEEYTLFNGFMHLSCGLCVGFACLSSGYAIGIVGDVGVRKYMHQPRLFVGIVLILIFSEVLGLYGMIIALILNTKGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV46</accession>
    <name>Q6FV46_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0E04840g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV46"/>
    <dbReference type="FunCoup" id="Q6FV46">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV46"/>
    <dbReference type="KEGG" id="cgr:2887337"/>
    <dbReference type="CGD" id="CAL0129124">
        <property type="gene designation" value="CAGL0E04840g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04840g"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_7_4_1"/>
    <dbReference type="InParanoid" id="Q6FV46"/>
    <dbReference type="OMA" id="KRGIQFC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072687">
        <property type="term" value="C:meiotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="6">
        <location>
            <begin position="35"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="366"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0129124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="400" mass="46122" checksum="E1D16FB75950EFC6" modified="2004-07-19" version="1">MTTIHGVGSAARFPRPISTHTIDAIQLRQKKNAKKPEHLCLLILGERGSGRSTFLANLCNYPDYTQSQAVEVCDPRRSHIAQKLKIIKKHLDLSSHINAPMILDLVIMEGFGDNFDNSGTSATISAYLNTQFENYLAEEEKIHRTGIIEDTRPHACLYFIKPNMRGLNDFDIEVLKKIQKQVNIIPILTKADILSQPELVSNKEIIKRQLRDNNIEIYDFGNDRIGDVFSYNDMHPFDKYTRSQNINEMVPFATTCSKLKYVHPWTAETLHIRKYSWGELIVEDFSNSEFAYLKGILFGSHVQELRNFTQNVLYETFRARKLLERRSAIVESNSIQQDIHHSMHRIVGLHFKQSDNSSKLSPNKLIDEKDQLLLDYERKLRDLETRLNSEQSKSTMSSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV63</accession>
    <name>Q6FV63_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0E04444g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV63"/>
    <dbReference type="FunCoup" id="Q6FV63">
        <property type="interactions" value="824"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV63"/>
    <dbReference type="KEGG" id="cgr:2887485"/>
    <dbReference type="CGD" id="CAL0128598">
        <property type="gene designation" value="CAGL0E04444g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04444g"/>
    <dbReference type="eggNOG" id="KOG3235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_2_1"/>
    <dbReference type="InParanoid" id="Q6FV63"/>
    <dbReference type="OMA" id="MSMQNAN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000107">
        <property type="entry name" value="N-terminal acetyltransferase complex ARD1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0128598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG58800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="232" mass="26675" checksum="FA68C57B8A4AED2B" modified="2004-07-19" version="1">MAITIRRATVNDMICMQNANLHNLPENYLMKYYMYHILSWPEASFVATTTCIEDELDEHEDDNLSIPDPEKPGIMIKLDPTYVAPGEKLVGYVLSKMNDDPDASNEAPNGHVTSLSVMRTYRRMGIAEKLMRQALFALREVYKAEYVSLHVRQSNRAALHLYRDTLAFEVLSIEKSYYQDGEDAYAMKKVLDLDELKISNYTHRKGQEKLEDDLKSDLLEDIITEGVDKIMV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVA1</accession>
    <name>NPR3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NPR3</name>
        <name type="synonym">RMD11</name>
        <name type="ordered locus">CAGL0E03608g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NPR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445843.1">
        <property type="nucleotide sequence ID" value="XM_445843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVA1"/>
    <dbReference type="SMR" id="Q6FVA1"/>
    <dbReference type="FunCoup" id="Q6FVA1">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVA1"/>
    <dbReference type="EnsemblFungi" id="CAGL0E03608g-T">
        <property type="protein sequence ID" value="CAGL0E03608g-T-p1"/>
        <property type="gene ID" value="CAGL0E03608g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887419"/>
    <dbReference type="KEGG" id="cgr:2887419"/>
    <dbReference type="CGD" id="CAL0129006">
        <property type="gene designation" value="CAGL0E03608g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_E03608g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E03608g"/>
    <dbReference type="eggNOG" id="ENOG502QW35">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014314_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVA1"/>
    <dbReference type="OMA" id="RTDYVWK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051058">
        <property type="term" value="P:negative regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000785">
        <property type="term" value="P:regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000301797" description="Nitrogen permease regulator 3">
        <location>
            <begin position="22"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="48"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="813"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="836"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="946" mass="108046" checksum="89435938D98D8AC1" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-03-08" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVB6</accession>
    <name>CHO2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="1">PE methyltransferase</shortName>
            <shortName evidence="1">PEAMT</shortName>
            <shortName evidence="1">PEMT</shortName>
            <ecNumber evidence="1">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CHO2</name>
        <name type="ordered locus">CAGL0E03201g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
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    </dbReference>
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        <property type="entry name" value="Phopholipid_MeTrfase"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04191">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
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    <keyword id="KW-0489">Methyltransferase</keyword>
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            <begin position="1"/>
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            <begin position="43"/>
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            <begin position="74"/>
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            <begin position="95"/>
            <end position="154"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="155"/>
            <end position="175"/>
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    </feature>
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            <begin position="176"/>
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            <begin position="244"/>
            <end position="255"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="277"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="347"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="373"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
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    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="420"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="445"/>
            <end position="486"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
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    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="508"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <sequence length="853" mass="99488" checksum="EBFB8DCABC7446D1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVD1</accession>
    <name>Q6FVD1_CANGA</name>
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        <recommendedName>
            <fullName evidence="4">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0E02849g</name>
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    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="GPAT/DAPAT"/>
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    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
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    </dbReference>
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        <property type="entry name" value="Acyltransferase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="514"/>
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    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="4">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="558"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="668"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0128956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG58732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="715" mass="80379" checksum="81B867BB6DDD6066" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVJ0</accession>
    <name>Q6FVJ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0E01507g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVJ0"/>
    <dbReference type="FunCoup" id="Q6FVJ0">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887439"/>
    <dbReference type="CGD" id="CAL0129018">
        <property type="gene designation" value="CAGL0E01507g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01507g"/>
    <dbReference type="eggNOG" id="ENOG502QQA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021993_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FVJ0"/>
    <dbReference type="OMA" id="ALQLLYW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0129018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="478" mass="53165" checksum="EEE37D06E713CF95" modified="2004-07-19" version="1">MSKVSGEEEYELGGLHEVNADASATSYFMKDGERREIEEVEGRAVVREVNWKGHDILLYDLDYEKLPMVRYQVAFCLVMFLVFGLNDQTTGSLLPTLTEHYNISTFTVSNIFLIQLSGYTCASLLNEKVHRMGGVRGAMVIVCMLCIVPLLVMAMKPSHFYIYMICCFPLGLGLGVMDSAANVLIGNLTQNKNEWMGILHALYGAAAMITPPTVSYFVKWGHWNLFFLIPLICCTAGLVLIYPAFKFETTAKYNYLSTLDGDGNETADTGVDETSLFQILKNPVVVLYSIYMFLYLGAEITTGSWFFTYLLKTKSDNRIGMSYVAASFWSGITLGRLLLGFVTKRLFSTEYNASNAYSWLSVVFFSLFVAIGLLNYSSIFYFACMFVSMFFGGFFIGPLFPNASIVALQNLPPKLHISGMGTAVAIGGCGGAGLPYLTGLIIHSCGEEIVPFMSWSMVVAFTIVWYLYPRFIPALKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVN9</accession>
    <name>Q6FVN9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein OCA4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0E00407g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVN9"/>
    <dbReference type="FunCoup" id="Q6FVN9">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVN9"/>
    <dbReference type="KEGG" id="cgr:2887524"/>
    <dbReference type="CGD" id="CAL0128594">
        <property type="gene designation" value="CAGL0E00407g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00407g"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036633_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVN9"/>
    <dbReference type="OMA" id="FQRDLWE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17662">
        <property type="entry name" value="PFA-DSP_Oca4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF70">
        <property type="entry name" value="PROTEIN OCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="42892" checksum="95B06EEA77C2CB6C" modified="2004-07-19" version="1">MLVPPASFGIAEEGIYRCSKVETLNLSFLEGLNLKTVIFVGGTEPSKFFKEFFTRSSIEWTAIRTADFSTVGSPLKNDLSLVSPHSYQKMHSDEDTQSRESLGEDGESIHSGTSLTIGMNKVISPQKMAYHFSDSDDLMLIKSKSLQRIFEKLLDRKNYNTLLVDKTSLVIGILRKIQKWNISSIINEYRLFAGKNRGYFAETFLEMIQIKIEQTIEERSLDEQQIDTIVSEEQQLPCVEHKSNPVELVDEDLLCDEPEVPERQLHIVEEAERKNRIKDIPRVNNILISDTSTSSSDLGIFGHRYRLAFTQKEQGQYEYYKSQDGNDDIETVCLKIPKENDLPGWFKFQRDLWEQENIPQIHHFYKEQIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVS9</accession>
    <name>Q6FVS9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0D05896g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAG58576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="CGD" id="CAL0127955">
        <property type="gene designation" value="CAGL0D05896g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05896g"/>
    <dbReference type="eggNOG" id="KOG2375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009985_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVS9"/>
    <dbReference type="OMA" id="YFTAPTW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:cellular response to glucose starvation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="226"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
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        <location>
            <begin position="413"/>
            <end position="435"/>
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    </feature>
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        <location>
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            <end position="454"/>
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        <location>
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    </feature>
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            <begin position="759"/>
            <end position="775"/>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0127955"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG58576.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="775" mass="83669" checksum="74894CB24CA9DBB6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVV0</accession>
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        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS5m</fullName>
        </recommendedName>
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        <name evidence="11 12" type="ordered locus">CAGL0D05412g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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            <taxon>Saccharomycetales</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
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                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
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        <text evidence="2 9">Belongs to the universal ribosomal protein uS5 family.</text>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Ribosomal_uS5"/>
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        <property type="entry name" value="Ribosomal_uS5_C"/>
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        <property type="entry name" value="Ribosomal_uS5_N"/>
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        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
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        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
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    <dbReference type="Pfam" id="PF00333">
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    </dbReference>
    <dbReference type="Pfam" id="PF03719">
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    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="3 8 9" id="KW-0689">Ribosomal protein</keyword>
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        <location>
            <begin position="159"/>
            <end position="223"/>
        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0128195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="322" mass="36806" checksum="4D6D328BDA01A8BE" modified="2004-07-19" version="1">MMFQRMFREAPMASRITRQVRLSSTSRDHLLKYYPPNLIKSIEMAEDVIYKGNSKPEFKVPSGVNFAPPYLEDYSKLHPFWDYAKNEPHIHMDSLNEEVRKYQWDDINFQQNSKLPPGTFEKEIVEAHVGKNSGSKTAELARGLNRQTGIDIDYITKKLVMKPLVLKRVSNQTGKGKIGSFYALVIVGDRNGMIGLGEGKSRDEMPKAIFKAHWDAIRNLKEIPRYENRTIYGDIDYRYHGVKLHLRSAKPGFGLRVNHVIFEICECAGIKDLSGKVYKSRNDMNIAKGTIEALIGAQKTLDDIAMARGKKLVDVRKVYYSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW13</accession>
    <name>FYV4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Protein FYV4, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">FYV4</name>
        <name type="ordered locus">CAGL0D03806g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in telomere length regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445581.1">
        <property type="nucleotide sequence ID" value="XM_445581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW13"/>
    <dbReference type="SMR" id="Q6FW13"/>
    <dbReference type="FunCoup" id="Q6FW13">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW13"/>
    <dbReference type="EnsemblFungi" id="CAGL0D03806g-T">
        <property type="protein sequence ID" value="CAGL0D03806g-T-p1"/>
        <property type="gene ID" value="CAGL0D03806g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887227"/>
    <dbReference type="KEGG" id="cgr:2887227"/>
    <dbReference type="CGD" id="CAL0128127">
        <property type="gene designation" value="CAGL0D03806g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_D03806g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03806g"/>
    <dbReference type="eggNOG" id="ENOG502SCMV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126121_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FW13"/>
    <dbReference type="OMA" id="FENKWEN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000292470" description="Small ribosomal subunit protein mS41">
        <location>
            <begin position="11"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="125" mass="14488" checksum="27DA79FE580461C2" modified="2004-07-19" version="1" precursor="true">MLSIFGCVRAVPRVVQMSARRTLKVPAPSQSIPDVEAFLKTIGRDCSELTETFENKWENLFEWDSKTLKSKGVSVQQRRYILHQAQKFRNGEPVKEMKKGKKSFFGGERNRKATVAKWRAEQRNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW67</accession>
    <name>PEX6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisomal ATPase PEX6</fullName>
            <ecNumber evidence="1">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Peroxin-6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Peroxisomal biogenesis factor 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PEX6</name>
        <name type="ordered locus">CAGL0D02574g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="1"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445527.1">
        <property type="nucleotide sequence ID" value="XM_445527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW67"/>
    <dbReference type="SMR" id="Q6FW67"/>
    <dbReference type="FunCoup" id="Q6FW67">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW67"/>
    <dbReference type="EnsemblFungi" id="CAGL0D02574g-T">
        <property type="protein sequence ID" value="CAGL0D02574g-T-p1"/>
        <property type="gene ID" value="CAGL0D02574g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887074"/>
    <dbReference type="KEGG" id="cgr:2887074"/>
    <dbReference type="CGD" id="CAL0128353">
        <property type="gene designation" value="PEX6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02574g"/>
    <dbReference type="eggNOG" id="KOG0736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_0_4_1"/>
    <dbReference type="InParanoid" id="Q6FW67"/>
    <dbReference type="OMA" id="DSMLNAM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904949">
        <property type="term" value="C:ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006625">
        <property type="term" value="P:protein targeting to peroxisome"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23111">
        <property type="entry name" value="N1_PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0576">Peroxisome</keyword>
    <keyword id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000084611" description="Peroxisomal ATPase PEX6">
        <location>
            <begin position="1"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="758"/>
            <end position="765"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P33760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1017" mass="114807" checksum="576EDBF85D80B5B4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2025-06-18" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW96</accession>
    <name>SNF7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SNF7</name>
        <name type="synonym">VPS32</name>
        <name type="ordered locus">CAGL0D01936g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">A component of the endosomal sorting required for transport complex III (ESCRT-III).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445498.1">
        <property type="nucleotide sequence ID" value="XM_445498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW96"/>
    <dbReference type="SMR" id="Q6FW96"/>
    <dbReference type="FunCoup" id="Q6FW96">
        <property type="interactions" value="737"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW96"/>
    <dbReference type="EnsemblFungi" id="CAGL0D01936g-T">
        <property type="protein sequence ID" value="CAGL0D01936g-T-p1"/>
        <property type="gene ID" value="CAGL0D01936g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887075"/>
    <dbReference type="KEGG" id="cgr:2887075"/>
    <dbReference type="CGD" id="CAL0128285">
        <property type="gene designation" value="SNF7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_D01936g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01936g"/>
    <dbReference type="eggNOG" id="KOG1656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071097_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FW96"/>
    <dbReference type="OMA" id="MKQIHGG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1060:FF:000012">
        <property type="entry name" value="Vacuolar sorting protein SNF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000211438" description="Vacuolar-sorting protein SNF7">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="228" mass="25827" checksum="15A9885DEF954FE0" modified="2004-07-19" version="1">MWASIFGGKGNTNKELPKKAIIELREHINLLSKKQAHLQGQITAQENEARKFLTRGNKTMAKNALKKKKVYEGQLVKLESQMDSLEQQLFSIESANLNLETMRAMKQGAKAMKSIHSGLDIDRVDETMDEIREQVELGEEISDAISRPLYTGANEIDEDELDEELDMLAQETEPQVATKEQALPESKQALSMPNIPNTKIDESKTKIEEEEEDEDERALRELQAEMGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2025-06-18" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWI7</accession>
    <name>SIR2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>NAD-dependent histone deacetylase SIR2</fullName>
            <ecNumber evidence="2">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Regulatory protein SIR2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Silent information regulator 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SIR2</name>
        <name type="ordered locus">CAGL0C05357g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="2"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWI7"/>
    <dbReference type="SMR" id="Q6FWI7"/>
    <dbReference type="FunCoup" id="Q6FWI7">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWI7"/>
    <dbReference type="EnsemblFungi" id="CAGL0C05357g-T">
        <property type="protein sequence ID" value="CAGL0C05357g-T-p1"/>
        <property type="gene ID" value="CAGL0C05357g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886842"/>
    <dbReference type="CGD" id="CAL0127390">
        <property type="gene designation" value="HST1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05357g"/>
    <dbReference type="eggNOG" id="KOG2684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FWI7"/>
    <dbReference type="OMA" id="FHKTIRK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045950">
        <property type="term" value="P:negative regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070623">
        <property type="term" value="P:regulation of thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007654">
        <property type="entry name" value="NAD-dep_histone_deAcase_SIR2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04574">
        <property type="entry name" value="DUF592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000110276" description="NAD-dependent histone deacetylase SIR2">
        <location>
            <begin position="1"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="2">
        <location>
            <begin position="185"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="292"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="420"/>
            <end position="422"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="445"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="509" mass="58274" checksum="6822A1CBED3D7964" modified="2004-07-19" version="1">MIISRGSHVDEEPVAKKPRISVGEMTDDTTDDGLNTEEIRAPYTTEEMDEPEKAALLPKIPKKSPVSIGMNPENGKYVLPNYSKDESLNARKFLKYYGLRKFLDTYLPEELNSLYIYSLIKLLGFEIRDKELLSSLYRFFHPVKSSDQFKLEYEDFTDPLEKKEAVKLIKDLQKAINRVLATRIRLSNFYTIDHFVSKIKKAERILVLTGAGVSTSLGIPDFRSSEGFYSKIQHLGLDDPQDVFNYDIFMQDPSVFYNIAHMILPPENMYSPLHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDPEKLVQCHGSFATASCVTCHWQIPGEKIFSNIRSMELPLCPYCYQKRREYFPNTGDEEYDTLKGNLESGIQNNNFALKSYGVLKPDITFFGEALPSKFHKTIREDIMKCDLLICIGTSLKVAPVSEIVNMIPAYVPQVLINKDPVKHAEFDIELLGFCDDVATVVAQKCEWDIPHKDWEGKLKKKRFDVNEIERGVFNIEAGSPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWK6</accession>
    <name>Q6FWK6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">triacylglycerol lipase</fullName>
            <ecNumber evidence="1">3.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0C04939g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWK6"/>
    <dbReference type="FunCoup" id="Q6FWK6">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="ESTHER" id="canga-q6fwk6">
        <property type="family name" value="Lipase_3"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886757"/>
    <dbReference type="CGD" id="CAL0127490">
        <property type="gene designation" value="CAGL0C04939g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04939g"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032957_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FWK6"/>
    <dbReference type="OMA" id="YEHRAYF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF3">
        <property type="entry name" value="LIPASE LIH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273514" description="triacylglycerol lipase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="139"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0127490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG58294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="370" mass="42337" checksum="8242D0D1192DE267" modified="2004-07-19" version="1">MKTVLLWHILTLAQRLWFGTWIIVEASSLNDYNSPIEVATKTAALENEAEQIHIGEEVYERFVYFSKACGLCNCIDKKLLRENKTLDDEGCPSYLNFCSDPSQNPTYNQTRIVLVLEAEENELGTGYLAVDHEKKVIILAFRASTTAQDWQSDFETYPKEYYPVSSNEYWDLVRHGVIKECTNCKVHKGFSRFLETLGKHFLAKVQKIITNYPDYHIVSVGHSLGAALAALAGIELKLRGYRVSVITYAQPKIFNRDLKEWVDDLFNTRLLNAIAEYGSCLSSATGYIRVVHENDYVPMIPPFFHHAGLEVVISTRELPHNIQHLTYIGYNNLVTTEKAERLGMNSNLEELLHMYEHRNYFITLTGCTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWV7</accession>
    <name>Q6FWV7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bromodomain-containing factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAGL0C02541g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference evidence="8 9 10" key="2">
        <citation type="journal article" date="2025" name="Adv. Sci." volume="12" first="e2404260" last="e2404260">
            <title>Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential.</title>
            <authorList>
                <person name="Wei K."/>
                <person name="Arlotto M."/>
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                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
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        <property type="nucleotide sequence ID" value="XM_445265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWX9"/>
    <dbReference type="KEGG" id="cgr:2886886"/>
    <dbReference type="CGD" id="CAL0127354">
        <property type="gene designation" value="CAGL0C02057g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02057g"/>
    <dbReference type="HOGENOM" id="CLU_2061192_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWX9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="119" mass="13969" checksum="ABFBDF6443A31433" modified="2004-07-19" version="1">MIWYYKDIEKVAGTQPVFQPQEIPEYQPQAPRPVGEPVEQWINSDAYAVELPIRNYSMIIHPQWQPPIEKQDEEKNQKLSILHKIGKVIWRPAVLDGIFVTICAIGIIYIIFMLFKYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX05</accession>
    <name>Q6FX05_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0C01485g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX05"/>
    <dbReference type="FunCoup" id="Q6FX05">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX05"/>
    <dbReference type="KEGG" id="cgr:2886946"/>
    <dbReference type="CGD" id="CAL0127210">
        <property type="gene designation" value="CAGL0C01485g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C01485g"/>
    <dbReference type="eggNOG" id="KOG1844">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020879_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FX05"/>
    <dbReference type="OMA" id="RPRYMNP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061188">
        <property type="term" value="P:negative regulation of rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15550">
        <property type="entry name" value="PHD_MLL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000593">
        <property type="entry name" value="Cti6p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053051">
        <property type="entry name" value="HDAC_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47793:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT CTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0127210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="540" mass="60876" checksum="D2D2974520CBDA59" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXA8</accession>
    <name>Q6FXA8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="9">DMRL synthase</shortName>
            <ecNumber evidence="4 9">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RIB4</name>
        <name evidence="10 11" type="ordered locus">CAGL0B01419g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2013" name="Acta Crystallogr. D" volume="69" first="1580" last="1586">
            <title>Catalysis product captured in lumazine synthase from the fungal pathogen Candida glabrata.</title>
            <authorList>
                <person name="Shankar M."/>
                <person name="Wilbanks S.M."/>
                <person name="Nakatani Y."/>
                <person name="Monk B.C."/>
                <person name="Tyndall J.D."/>
            </authorList>
            <dbReference type="PubMed" id="23897480"/>
            <dbReference type="DOI" id="10.1107/s0907444913010949"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.24 ANGSTROMS) OF 2-168 IN COMPLEX WITH 6,7-DIMETHYL-8-(1-D-RIBITYL)LUMAZINE</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homopentamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 9"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445031.1">
        <property type="nucleotide sequence ID" value="XM_445031.1"/>
    </dbReference>
    <dbReference type="PDB" id="4KQ6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.24 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J=2-168"/>
    </dbReference>
    <dbReference type="PDBsum" id="4KQ6"/>
    <dbReference type="AlphaFoldDB" id="Q6FXA8"/>
    <dbReference type="SMR" id="Q6FXA8"/>
    <dbReference type="FunCoup" id="Q6FXA8">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXA8"/>
    <dbReference type="GeneID" id="2886523"/>
    <dbReference type="KEGG" id="cgr:2886523"/>
    <dbReference type="CGD" id="CAL0127888">
        <property type="gene designation" value="RIB4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01419g"/>
    <dbReference type="eggNOG" id="KOG3243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FXA8"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="BRENDA" id="2.5.1.78">
        <property type="organism ID" value="1113"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q6FXA8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000007">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>6,7-dimethyl-8-(1-D-ribityl)lumazine</name>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>6,7-dimethyl-8-(1-D-ribityl)lumazine</name>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>6,7-dimethyl-8-(1-D-ribityl)lumazine</name>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>6,7-dimethyl-8-(1-D-ribityl)lumazine</name>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>6,7-dimethyl-8-(1-D-ribityl)lumazine</name>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>6,7-dimethyl-8-(1-D-ribityl)lumazine</name>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0127888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG57931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="4KQ6"/>
        </source>
    </evidence>
    <sequence length="168" mass="18278" checksum="DCAAC2C39210FCF5" modified="2004-07-19" version="1">MAVKGLGQLDQNYDGSKLRVGIIHARWNRVIIDALVKGAIDRMLSLGVKEENIIVETVPGSFELPYGSKRFAEKQAKKGEPLDVVIPIGVLIKGSTMHFEYISDSTTQAIMNLQDKINIPVIFGLLTCLTEEQALARAGIDEGKTMHNHGEDWGAAAVEMATKFGANA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXI5</accession>
    <name>CIN8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Kinesin-like protein CIN8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CIN8</name>
        <name type="ordered locus">CAGL0B03641g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Elongates the mitotic spindle by interacting with spindle microtubules to generate an outward force pushing spindle poles apart (By similarity). Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force, possibly generated by KAR3, that draws separated poles back together.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <text evidence="1">Spindle microtubules that lie between the poles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445130.1">
        <property type="nucleotide sequence ID" value="XM_445130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXI5"/>
    <dbReference type="SMR" id="Q6FXI5"/>
    <dbReference type="FunCoup" id="Q6FXI5">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXI5"/>
    <dbReference type="EnsemblFungi" id="CAGL0B03641g-T">
        <property type="protein sequence ID" value="CAGL0B03641g-T-p1"/>
        <property type="gene ID" value="CAGL0B03641g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886646"/>
    <dbReference type="KEGG" id="cgr:2886646"/>
    <dbReference type="CGD" id="CAL0127858">
        <property type="gene designation" value="CAGL0B03641g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03641g"/>
    <dbReference type="eggNOG" id="KOG0243">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_33_3_1"/>
    <dbReference type="InParanoid" id="Q6FXI5"/>
    <dbReference type="OMA" id="EVQECKR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000235">
        <property type="term" value="C:astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098653">
        <property type="term" value="P:centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061805">
        <property type="term" value="P:mitotic spindle elongation (spindle phase three)"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033047">
        <property type="term" value="P:regulation of mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0505">Motor protein</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000125366" description="Kinesin-like protein CIN8">
        <location>
            <begin position="1"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="33"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="965"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="514"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="707"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="125"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P27895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="988" mass="111387" checksum="77BC1A5B97CEFEBC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXS3</accession>
    <name>Q6FXS3_CANGA</name>
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        <recommendedName>
            <fullName evidence="5">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SWI4</name>
        <name evidence="6 7" type="ordered locus">CAGL0A04565g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444966.1">
        <property type="nucleotide sequence ID" value="XM_444966.1"/>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXS3"/>
    <dbReference type="GeneID" id="2886354"/>
    <dbReference type="KEGG" id="cgr:2886354"/>
    <dbReference type="CGD" id="CAL0126629">
        <property type="gene designation" value="SWI4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04565g"/>
    <dbReference type="eggNOG" id="ENOG502QUTG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009666_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXS3"/>
    <dbReference type="OMA" id="VDVYECY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:identical protein binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0034605">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF7">
        <property type="entry name" value="REGULATORY PROTEIN SWI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
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    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="HTH_APSES"/>
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    </dbReference>
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    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="5">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
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        <location>
            <begin position="482"/>
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        </location>
    </feature>
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        <location>
            <begin position="603"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
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            <begin position="198"/>
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        </location>
    </feature>
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        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0126629"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG57859.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1041" mass="116641" checksum="F73C139BD382E68C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXS6</accession>
    <name>DPH3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DPH3</name>
        <name type="ordered locus">CAGL0A04499g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXS6"/>
    <dbReference type="SMR" id="Q6FXS6"/>
    <dbReference type="FunCoup" id="Q6FXS6">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXS6"/>
    <dbReference type="EnsemblFungi" id="CAGL0A04499g-T">
        <property type="protein sequence ID" value="CAGL0A04499g-T-p1"/>
        <property type="gene ID" value="CAGL0A04499g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886339"/>
    <dbReference type="CGD" id="CAL0126843">
        <property type="gene designation" value="CAGL0A04499g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_A04499g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04499g"/>
    <dbReference type="eggNOG" id="KOG2923">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155991_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FXS6"/>
    <dbReference type="OMA" id="LFTYPCP"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016730">
        <property type="term" value="F:oxidoreductase activity, acting on iron-sulfur proteins as donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000082628" description="Diphthamide biosynthesis protein 3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q3E840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="82" mass="9220" checksum="E3583BBECDEAFE52" modified="2004-07-19" version="1">MSTYDQIEIEDMTFHPDSQMFTYPCPCGDRFQILLDDMFDGEAIAVCPSCSLMIDVIFEKEDLDEYYEEAGIAPPQPIAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXS7</accession>
    <name>Q6FXS7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0A04477g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXS7"/>
    <dbReference type="FunCoup" id="Q6FXS7">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXS7"/>
    <dbReference type="MEROPS" id="C19.100"/>
    <dbReference type="KEGG" id="cgr:2886392"/>
    <dbReference type="CGD" id="CAL0126763">
        <property type="gene designation" value="CAGL0A04477g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04477g"/>
    <dbReference type="eggNOG" id="KOG1864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008279_12_1_1"/>
    <dbReference type="InParanoid" id="Q6FXS7"/>
    <dbReference type="OMA" id="FASEYTH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000131">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="150"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="710"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0126763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG57855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="770" mass="86772" checksum="31E1B9B68726581A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXW0</accession>
    <name>Q6FXW0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0A00165g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444779.1">
        <property type="nucleotide sequence ID" value="XM_444779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXW0"/>
    <dbReference type="KEGG" id="cgr:2886422"/>
    <dbReference type="CGD" id="CAL0126541">
        <property type="gene designation" value="CAGL0A00165g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A00165g"/>
    <dbReference type="eggNOG" id="ENOG502S1H9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001781_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXW0"/>
    <dbReference type="OMA" id="SESPRIW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0126541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG57670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="279" mass="33169" checksum="652819AFA7280699" modified="2004-07-19" version="1">MYELNNEEVLRKRKERFSKFGKEAIINDPLRDVALLSRSGESNTIIDLKINHDKRSEMVSMLKLLFYDEKQLTTVEHGLRKLREVFMSIRQDHRDEDESFWKQASEVYKLSYDFLLRHGQYNKLGGLVLNAIHEWFPLQYRKPYAKIYALYLSHIEKDVPKCVDFLQYSSVSQSESLDIINMANIYVLKSESPRIWFHYCKNLKDDELNFLELSSVMQVMINRTDNLLQLCYNQLSVKVAQQLWFGDHFTSNLETRIKDKYDMRAGTDIILFKKRQIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY77</accession>
    <name>Q6FY77_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0A03410g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444916.1">
        <property type="nucleotide sequence ID" value="XM_444916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY77"/>
    <dbReference type="KEGG" id="cgr:2886333"/>
    <dbReference type="CGD" id="CAL0126739">
        <property type="gene designation" value="CAGL0A03410g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A03410g"/>
    <dbReference type="HOGENOM" id="CLU_1124389_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY77"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0126739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG57809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="247" mass="29300" checksum="5969F2E6DB4C3069" modified="2004-07-19" version="1">MTTESFKFQKVSVKKICLPEPLQWEPDTAIVEEQKSYLRTPRTANDDDQSILASILSKWSQMIRKSIRNYKQRKRNRLKFCHNLNGKYLGLNNTKLSTNFILPDIPVTMSTNEREWLPQIEPIMVRDMVIEFPTIESITYSEADITTLSNDVPQIIDFYLDNDIDDIESLKHRKNMISIKKRLVEQKITDLTNLLQRKTPEHCYRQRTSRDKVISMMNDLQRLNFEVETKKRTIELLKSQNLRMPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN15</accession>
    <name>B4UN15_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0I05098g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for protein translocation in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAR58031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN15"/>
    <dbReference type="FunCoup" id="B4UN15">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UN15"/>
    <dbReference type="KEGG" id="cgr:9488009"/>
    <dbReference type="CGD" id="CAL0132526">
        <property type="gene designation" value="CAGL0I05098g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05098g"/>
    <dbReference type="eggNOG" id="KOG3457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133423_1_1_1"/>
    <dbReference type="InParanoid" id="B4UN15"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006398">
        <property type="entry name" value="Sec61_beta_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0132526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAR58031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="85" mass="9005" checksum="30210AF528B8F660" modified="2008-09-23" version="1">MSSSAVSAGSEKPIQRKGKTASEKNSREGTPGTPALKNSNSILKIYSDEAKGLRVDPLVVLFLAVGFIFSVVGLHVISKITSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN23</accession>
    <name>B4UN23_CANGA</name>
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                <person name="Lafontaine I."/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3088968_0_0_1"/>
    <dbReference type="InParanoid" id="B4UN48"/>
    <dbReference type="OMA" id="NIFVESH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035195">
        <property type="entry name" value="Emr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17237">
        <property type="entry name" value="Emr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAR58064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="52" mass="6066" checksum="0B5784C995491253" modified="2008-09-23" version="1">MIFFYQQIRAIFTHSHSTKRQIQLSRRAFFQLLGFLGSCVVISLAAQSNYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN54</accession>
    <name>B4UN54_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L10092g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAR58070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002999597.1">
        <property type="nucleotide sequence ID" value="XM_002999551.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:9488053"/>
    <dbReference type="CGD" id="CAL0135928">
        <property type="gene designation" value="CAGL0L10092g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10092g"/>
    <dbReference type="eggNOG" id="ENOG502SFJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002219_0_0_1"/>
    <dbReference type="InParanoid" id="B4UN54"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049451">
        <property type="entry name" value="AWP2-like_YTTT_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20646">
        <property type="entry name" value="Hpf1_C"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002827133" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1242"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0135928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAR58070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1416" mass="152341" checksum="124C18945F495173" modified="2008-09-23" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FII6</accession>
    <name>Q6FII6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Thiamine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TNR2</name>
        <name evidence="10 11" type="ordered locus">CAGL0M14113g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449958.1">
        <property type="nucleotide sequence ID" value="XM_449958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FII6"/>
    <dbReference type="FunCoup" id="Q6FII6">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FII6"/>
    <dbReference type="GeneID" id="2891620"/>
    <dbReference type="KEGG" id="cgr:2891620"/>
    <dbReference type="CGD" id="CAL0137265">
        <property type="gene designation" value="TNR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M14113g"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FII6"/>
    <dbReference type="OMA" id="WEVNNNY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903089">
        <property type="term" value="F:5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043132">
        <property type="term" value="P:NAD transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000005">
        <property type="entry name" value="Thiamine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="548"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0137265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="64862" checksum="5B9A8060FBE534CE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIN1</accession>
    <name>Q6FIN1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M13101g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIN1"/>
    <dbReference type="FunCoup" id="Q6FIN1">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIN1"/>
    <dbReference type="KEGG" id="cgr:2891203"/>
    <dbReference type="CGD" id="CAL0137329">
        <property type="gene designation" value="CAGL0M13101g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13101g"/>
    <dbReference type="eggNOG" id="ENOG502RZQS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050573_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FIN1"/>
    <dbReference type="OMA" id="YRSQHRI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061093">
        <property type="term" value="P:negative regulation of phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="341" mass="39427" checksum="F94096443F27239E" modified="2004-07-19" version="1">MFKRPGNYFFIVPWIAFIPWYGMLIAMLICWAAQGHPIYWFMHTEQFPVYISDIGATNLRPLFIACAGWQGLGYVITIACEYFQRAGRWPFRMPNSKSPHVEAEYDNVSSYTERLLHSRLLMPPYYTKHERNLIFASFVLGCIGEIALLMCSIFSTAKYHHVHISMVAIFCIFMLLSIVCLTAEYFSMGRHYASIHPLAATKADFDPSNPTNIDSLPWNKWTGHIWNKFTISATLKTIWCIAAIVWAICFGAIHDNSKSACFEWLLAFWFGIIFMIISADFYLGSLYKRSKYFHQIETFAGYYKYDKFAGVRDYESNDSSGKYEDSDRTETMVQEDSPVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIQ0</accession>
    <name>Q6FIQ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0M12683g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449894.1">
        <property type="nucleotide sequence ID" value="XM_449894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIQ0"/>
    <dbReference type="FunCoup" id="Q6FIQ0">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIQ0"/>
    <dbReference type="KEGG" id="cgr:2891445"/>
    <dbReference type="CGD" id="CAL0137499">
        <property type="gene designation" value="CAGL0M12683g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M12683g"/>
    <dbReference type="eggNOG" id="ENOG502QUEX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011125_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FIQ0"/>
    <dbReference type="OMA" id="HWDKTVL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="161"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0137499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="658" mass="74260" checksum="19D447CA86755EE4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIT3</accession>
    <name>Q6FIT3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M11946g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIT3"/>
    <dbReference type="FunCoup" id="Q6FIT3">
        <property type="interactions" value="777"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIT3"/>
    <dbReference type="KEGG" id="cgr:2891256"/>
    <dbReference type="CGD" id="CAL0137491">
        <property type="gene designation" value="CAGL0M11946g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11946g"/>
    <dbReference type="eggNOG" id="KOG2667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034705_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FIT3"/>
    <dbReference type="OMA" id="MHCIPTQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061852">
        <property type="term" value="C:retrograde transporter complex, Golgi to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="145"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0137491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="415" mass="46614" checksum="7F1CF7C84979A3B6" modified="2004-07-19" version="1">MKKSTLLSFDAFAKTEEDVRIRTRSGGFITLGCLVVTLMLLLSEWRDFNSVVTRPELVIDRDRSLRLDLNLDITFPSMPCELLTLDIMDDSGEVQLDIMNAGFEKTRLSKEGKVLGTADMKIGEAAKKDKEAQLAKLGANYCGNCYGARDQGKNNDDTPRDQWVCCQTCDDVRQAYFEKNWAFFDGKDIEQCEREGYVQKIADQLQEGCRVSGSAQLNRIDGNLHFAAGPGFQNIRGHFHDDSLYIQHPNLNFNHIINHLSFGKAVEPTKKGKVMGIEKVTVNPLDGHSMFPPRDAHFLQYSYYAKIVPTRYEGLNKKNMVETAQFSSTFHIRPVGGGSDDDHPNTVHQRGGSPSMWINFEMSPLKVINREEHGQSWSGFVLNCITSIGGVLAVGTVLDKALYKAQRTIFQKKDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIW5</accession>
    <name>Q6FIW5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0M11242g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIW5"/>
    <dbReference type="FunCoup" id="Q6FIW5">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIW5"/>
    <dbReference type="KEGG" id="cgr:2891398"/>
    <dbReference type="CGD" id="CAL0137071">
        <property type="gene designation" value="CAGL0M11242g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11242g"/>
    <dbReference type="eggNOG" id="KOG1205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="InParanoid" id="Q6FIW5"/>
    <dbReference type="OMA" id="WRWMWET"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052588">
        <property type="term" value="F:diacetyl reductase ((S)-acetoin forming) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031132">
        <property type="term" value="F:serine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045149">
        <property type="term" value="P:acetoin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000047">
        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0137071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29183" checksum="C5F3395E2221C442" modified="2004-07-19" version="1">MSQGRKAAERLQGKIAFITGASAGIGKATAIEYLDASNGSVKLVLGARRMEKLEELKKELLAQYPDAKIHIGKLDVTDFENVKQFLADLPEEFKDIDILINNAGKALGSDKVGDIDPEDIAGMVNTNVLALINLTQLLLPLFKKKNSGDIVNLGSIAGRDAYPTGAIYCATKHAVRAFTQSLRKELINTDIRVIEIAPGMVETEFSVVRYKGDKSKADDVYRGTTPLYADDIADLIVYSTSRKPNMVVADVLVFPTHQASASHIYRGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ22</accession>
    <name>EFM7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM7</name>
        <name type="synonym">NNT1</name>
        <name type="ordered locus">CAGL0M09801g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449772.1">
        <property type="nucleotide sequence ID" value="XM_449772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ22"/>
    <dbReference type="SMR" id="Q6FJ22"/>
    <dbReference type="FunCoup" id="Q6FJ22">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ22"/>
    <dbReference type="EnsemblFungi" id="CAGL0M09801g-T">
        <property type="protein sequence ID" value="CAGL0M09801g-T-p1"/>
        <property type="gene ID" value="CAGL0M09801g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891336"/>
    <dbReference type="KEGG" id="cgr:2891336"/>
    <dbReference type="CGD" id="CAL0136847">
        <property type="gene designation" value="CAGL0M09801g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M09801g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09801g"/>
    <dbReference type="eggNOG" id="KOG2920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032409_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ22"/>
    <dbReference type="OMA" id="VGHNPLW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000096892" description="Protein N-terminal and lysine N-methyltransferase EFM7">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="256" mass="29176" checksum="3EA9B15469C66D21" modified="2004-07-19" version="1">MSDTESLNDALGLFDEPEDFRPEKPKEHYANYERIDVPDISKSKITNLKLQLVGSSPLWGHLLWNAGIYTARHLDKYPELVSNKNVLELGAASALPSLVAGLIGAKRAVVTDYPDADLMANIQYNVNTIIPDELKENVRVEGYIWGNEYDPLTIHLDGDKKFDLIILSDLVFNHNQHDKLLQTTKDLLATNGKALVVFSPHRPHLLEADLQFFETCKEYGLTPEKIEMVNWKPMFEEDEETAEVRSRVYAYYMTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ87</accession>
    <name>Q6FJ87_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0M08316g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ87"/>
    <dbReference type="FunCoup" id="Q6FJ87">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ87"/>
    <dbReference type="KEGG" id="cgr:2891266"/>
    <dbReference type="CGD" id="CAL0136235">
        <property type="gene designation" value="CAGL0M08316g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08316g"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010370_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ87"/>
    <dbReference type="OMA" id="YAMYCLT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016241">
        <property type="entry name" value="Nnk1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF76">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000610">
        <property type="entry name" value="Ser/Thr_PK_YKL171w_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="487"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="778"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="363"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0136235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="964" mass="108967" checksum="588687607AF8DE8D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJN0</accession>
    <name>MBF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MBF1</name>
        <name type="ordered locus">CAGL0M04983g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449564.1">
        <property type="nucleotide sequence ID" value="XM_449564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJN0"/>
    <dbReference type="SMR" id="Q6FJN0"/>
    <dbReference type="FunCoup" id="Q6FJN0">
        <property type="interactions" value="821"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJN0"/>
    <dbReference type="EnsemblFungi" id="CAGL0M04983g-T">
        <property type="protein sequence ID" value="CAGL0M04983g-T-p1"/>
        <property type="gene ID" value="CAGL0M04983g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891574"/>
    <dbReference type="KEGG" id="cgr:2891574"/>
    <dbReference type="CGD" id="CAL0136719">
        <property type="gene designation" value="CAGL0M04983g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M04983g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04983g"/>
    <dbReference type="eggNOG" id="KOG3398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112609_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJN0"/>
    <dbReference type="OMA" id="GKNKSCK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000015">
        <property type="entry name" value="Endothelial differentiation-related factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000149804" description="Multiprotein-bridging factor 1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="85"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O14467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="151" mass="16356" checksum="67CC8BFD3C202D64" modified="2004-07-19" version="1">MSDWESHTVIGQKARAGGSGPRANVARTQGQINAARRQGLVLSVDKKYGTANTKGDAEGQRLTKVDRETDIVKPKKLDANVGKTIARVRTEKKMSQKDLATKINEKPTVINDYEAGRAIPNQQVLGKMERALGVKLRGKAIGEPLGGPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJW8</accession>
    <name>Q6FJW8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">phosphopentomutase</fullName>
            <ecNumber evidence="14">5.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0M02981g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-ribose 1-phosphate = D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:18793"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="5.4.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.7" evidence="14"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJW8"/>
    <dbReference type="FunCoup" id="Q6FJW8">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJW8"/>
    <dbReference type="KEGG" id="cgr:2891484"/>
    <dbReference type="CGD" id="CAL0136359">
        <property type="gene designation" value="CAGL0M02981g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02981g"/>
    <dbReference type="eggNOG" id="KOG1220">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJW8"/>
    <dbReference type="OMA" id="GYCVDPE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046115">
        <property type="term" value="P:guanosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006148">
        <property type="term" value="P:inosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000037">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="50"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="17">
        <location>
            <begin position="222"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="18">
        <location>
            <begin position="343"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="15">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0136359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG62452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="617" mass="69615" checksum="15BE21BCE7B77BF3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK13</accession>
    <name>Q6FK13_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA mismatch repair protein MLH3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0M01980g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK13"/>
    <dbReference type="SMR" id="Q6FK13"/>
    <dbReference type="FunCoup" id="Q6FK13">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK13"/>
    <dbReference type="KEGG" id="cgr:2891757"/>
    <dbReference type="CGD" id="CAL0137003">
        <property type="gene designation" value="CAGL0M01980g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01980g"/>
    <dbReference type="eggNOG" id="KOG1977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005415_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FK13"/>
    <dbReference type="OMA" id="FECAHGR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061982">
        <property type="term" value="P:meiosis I cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03486">
        <property type="entry name" value="MutL_Trans_MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="4">
        <location>
            <begin position="245"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="506"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0137003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="736" mass="85670" checksum="C5E1B72F10120B1F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK39</accession>
    <name>Q6FK39_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0M01386g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FK39">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891174"/>
    <dbReference type="CGD" id="CAL0136905">
        <property type="gene designation" value="CAGL0M01386g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01386g"/>
    <dbReference type="eggNOG" id="KOG1032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002908_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK39"/>
    <dbReference type="OMA" id="YIMVRQI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1284"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="10">
        <location>
            <begin position="851"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="10">
        <location>
            <begin position="1059"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="115"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="586"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1036"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1398"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0136905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG62381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1427" mass="160061" checksum="D11A54CE9DC69FBE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK82</accession>
    <name>Q6FK82_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TEL2-interacting protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M00396g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK82"/>
    <dbReference type="KEGG" id="cgr:2891280"/>
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        <property type="gene designation" value="CAGL0M00396g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00396g"/>
    <dbReference type="eggNOG" id="ENOG502QU79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054067_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK82"/>
    <dbReference type="OMA" id="SSNLWWI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071472">
        <property type="term" value="P:cellular response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="49073" checksum="78B8177F5453922A" modified="2004-07-19" version="1">MKCGNLIIVADGVIDDKDIINLACDEVLDTDDDLIHNDALDWRNIILNLSFRCYSVNDEDYLLAEKSNLVISRYFSRASRDKILEITSFLITKIQPLLINKKNAVIDKQSKGLNPKLGFSFGDDEVYEIWKKNGGIRSIPLCLTILSHLPIDKISTNLWWISPFILNLLDATSDLQNLRLPGVKLLHVMLEKVFIDQYSNKWLKFKDTGLFQEYERILINFCFYLPPSYDSQNTLLIWRQVFPAIYSLYKAQYIEDEYQLRLHILKFISEVILQNCLPRCGCKYDQLTSFLIHFMIEMIRTLGEKSTIYIQRVIYDIGQYLIKDPFFTAFDKLIFETIELVEAIIGYCNTTRVLEHKYDILGIILLIYGKLKNEESMSDKIRKQLQHTIKMLKDRGCNFSYEIKHLKSVKGIDYTELFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK94</accession>
    <name>Q6FK94_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAGL0M00132g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK94"/>
    <dbReference type="STRING" id="284593.Q6FK94"/>
    <dbReference type="KEGG" id="cgr:2891153"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00132g"/>
    <dbReference type="eggNOG" id="ENOG502S8JT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308156_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK94"/>
    <dbReference type="OMA" id="TANILFC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274623" description="PA14 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="904"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="4">
        <location>
            <begin position="91"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="922" mass="99506" checksum="FD805B5BB190ACF7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKG6</accession>
    <name>Q6FKG6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L11748g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAG62252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKG6"/>
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    <dbReference type="CGD" id="CAL0136010">
        <property type="gene designation" value="CAGL0L11748g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11748g"/>
    <dbReference type="eggNOG" id="KOG3182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070703_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKG6"/>
    <dbReference type="OMA" id="WIFGYGE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0136010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="236" mass="26960" checksum="7FC7982820E8BB3D" modified="2004-07-19" version="1">MTVEKCGIWVLGYGSLIYKPPPHYTHRIPAVIYGFMRRFWQSSVDHRGTPDSPGRVVTLIPHDEIMKTPRFLQDYVKYENHGNPITNLQPNDLHTIGVVYYIPADRADEVREYLDVREQNGYTLHEVEVHLDLTESDSSDQELMAAIHQLPEHETTGKKVLTTNVYIGTVSNEAFVGPETIEQTASVIATNVGPSGTNFDYLRMLCESMASMKTCEETDKYLEHLFKEVNRIRDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKG8</accession>
    <name>Q6FKG8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein SPT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0L11704g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKG8"/>
    <dbReference type="FunCoup" id="Q6FKG8">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKG8"/>
    <dbReference type="KEGG" id="cgr:2890977"/>
    <dbReference type="CGD" id="CAL0134974">
        <property type="gene designation" value="CAGL0L11704g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11704g"/>
    <dbReference type="eggNOG" id="ENOG502QRG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069667_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKG8"/>
    <dbReference type="OMA" id="IWAMFNR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000217">
        <property type="term" value="F:DNA secondary structure binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140713">
        <property type="term" value="F:histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0134974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="39196" checksum="468A3B0A674CDF2F" modified="2004-07-19" version="1">MSFLSKLSELKKTKPKTVISPPQKANKQEEISLLPKNYVREEDPAVTRLKELRRQELLKNPELAKKKQKQVRKTPSSSKASTGKKDKNGDDNMLVSRFKRKVGSDKPAVPIQVKKKPQPIKKLSFEELMKQAENNQTIPVSKDTQSNGAGEKIKGSAKLNKPGFKTSRPKSLSPTTHINKTDHGKDKSTAKEKSEPVVKIGIPKFAQPNERLKKKLEMRQRVNKSRRYEDEEDDMDDFIEDDEEEYSSYRTTSKDPGYDRDEIWAMFNKGRKRSYNEYMDYEEEDDFDAMEANEMEILEEEEEAARMARLEDKREEAWLKKHEQEKKKKKLKLQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKR6</accession>
    <name>Q6FKR6_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L09251g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKR6"/>
    <dbReference type="KEGG" id="cgr:2891123"/>
    <dbReference type="CGD" id="CAL0135768">
        <property type="gene designation" value="CAGL0L09251g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09251g"/>
    <dbReference type="HOGENOM" id="CLU_986943_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKR6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="282" mass="32052" checksum="1916F9C3D17967A6" modified="2004-07-19" version="1">MSLDGIINGYTVLNLNHSSDRFSIYNAKDRNGSPCLLKVCHDGGSKQTAYKQATSDAMLESFIYNNNGEEIQCYIFPTSTLDYFTCNQSSNPTKSHQSRLKTLKSGIRYELLKTPTPDGGMQFACHSSDDCDDDDNDDDDDDEEEEEEEEEEEEEEEELENSDSDSDEDEDLEVNIIVHDDIAKCPLEPILNSKNQPNAELEYIHTSQEHIHFVNNPVLQRVCHRQHRPIVRTPVPKSCPAYHDGVQDNIQQKKLSCQKGQFELQMLQSSMLKRRSTSSAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKS4</accession>
    <name>Q6FKS4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L09086g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKS4"/>
    <dbReference type="FunCoup" id="Q6FKS4">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKS4"/>
    <dbReference type="KEGG" id="cgr:2891102"/>
    <dbReference type="CGD" id="CAL0135708">
        <property type="gene designation" value="CAGL0L09086g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09086g"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FKS4"/>
    <dbReference type="OMA" id="DWSYNIC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="480" mass="53147" checksum="D83D63167A72F842" modified="2004-07-19" version="1">MKVLLTHTTRSLHTSRILSSSTASSLKQRLKEVIPDKREKFTKIKKNYSDVKVGDITIGSVIGGMRGNQSMFWQGTSLDPEEGIRFQGLSIPECMDQMAGISEIHGGSKSLLPESMLWLLMTGELPTKEQTNSLSKELAERGKILPQSVNTIVSNLPKDMHPMTQLAIGLASLNQYSQFAKEYEKGSIGKNDYWDFIYEDVLNLIASLPHLTGQIYANITNEGKPLGEFNENADWAYNISSLLGMTTEASSANKQNLSEKRAQDFADLVRLYTAIHVDHEGGNVSAHATHLVGSALGDPFISYASGIMGLAGPLHGLAAQEVVRFLVEMNASISSPENVPEIENYLWSILNSRRVVPGYGHAVLRKPDPRFNAMLNFAKERPDEFQSDKNVLLMENLSTIAPKVLQEHGKCKNPFPNVDSASGILFHHYGIQETLFFTVIFGCSRAIGSLTQLVWDRILGLPIERPRSLDMAALERLCNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL14</accession>
    <name>Q6FL14_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L06974g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449080.1">
        <property type="nucleotide sequence ID" value="XM_449080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL14"/>
    <dbReference type="FunCoup" id="Q6FL14">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="ESTHER" id="canga-q6fl14">
        <property type="family name" value="Dienelactone_hydrolase"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890825"/>
    <dbReference type="CGD" id="CAL0136180">
        <property type="gene designation" value="CAGL0L06974g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06974g"/>
    <dbReference type="eggNOG" id="ENOG502QQFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FL14"/>
    <dbReference type="OMA" id="CATCFFP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="273" mass="30640" checksum="A4AAD1B3F8055A3D" modified="2004-07-19" version="1">MLITESYHDVKTKEGNTLRIFVFSPKVKGYPNAKFPGVIVYSEIYQVTGPVARFAQKIASEGYVVVAPAIYHNFIGPEPLPYDVKGTDLGNEYKIKKPIPSYDEDNKLCCDLLYSLPQFDGKRIGATGMCLGGHLAFRALLDKRVNCATCFFPTDIHLKSLGLGKNDDSLERVSQEASKDQELVLIFGTADTHVSPEGRDLIRKTLRDQGVNFTFLEILDAQHAFIRDEFSKGRYDAAITQSCLGFLFEQFNRKLKTDLGEYVPDNKPLEHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL49</accession>
    <name>Q6FL49_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome c oxidase subunit 13, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0L06204g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL49"/>
    <dbReference type="FunCoup" id="Q6FL49">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL49"/>
    <dbReference type="KEGG" id="cgr:2890753"/>
    <dbReference type="CGD" id="CAL0135522">
        <property type="gene designation" value="CAGL0L06204g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06204g"/>
    <dbReference type="eggNOG" id="KOG3469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122515_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FL49"/>
    <dbReference type="OMA" id="KLPWMVD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00925">
        <property type="entry name" value="Cyt_c_Oxidase_VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000277">
        <property type="entry name" value="COX6A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0135522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG62015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="128" mass="14806" checksum="5A4152601E2F1956" modified="2004-07-19" version="1">MYRQALRRYATLPPHALKPAFGKPNEAAAKAFKQSLEATEKHAVGTTSVWVKISLFVALPAIALTAVNTYFVEKEHADHREHLKHVPDSEWPRDYEFQNIRSKPFFWGNGDKTLFWNPVINRHINHDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLB2</accession>
    <name>DAM1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DAM1</name>
        <name type="ordered locus">CAGL0L04752g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the DASH complex consisting of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with a stoichiometry of one copy of each subunit per complex. Multiple DASH complexes oligomerize to form a ring that encircles spindle microtubules and organizes the rod-like NDC80 complexes of the outer kinetochore. DASH complex oligomerization strengthens microtubule attachments. Within the complex, DAM1 and DUO1 may form the microtubule connections (By similarity). On cytoplasmic microtubules, DASH complexes appear to form patches instead of rings (By similarity). Interacts with the outer kinetochore component NDC80; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448982.1">
        <property type="nucleotide sequence ID" value="XM_448982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLB2"/>
    <dbReference type="SMR" id="Q6FLB2"/>
    <dbReference type="FunCoup" id="Q6FLB2">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLB2"/>
    <dbReference type="EnsemblFungi" id="CAGL0L04752g-T">
        <property type="protein sequence ID" value="CAGL0L04752g-T-p1"/>
        <property type="gene ID" value="CAGL0L04752g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890705"/>
    <dbReference type="KEGG" id="cgr:2890705"/>
    <dbReference type="CGD" id="CAL0135764">
        <property type="gene designation" value="CAGL0L04752g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L04752g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04752g"/>
    <dbReference type="eggNOG" id="ENOG502S08R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065404_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLB2"/>
    <dbReference type="OMA" id="GLMCNSW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098653">
        <property type="term" value="P:centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051987">
        <property type="term" value="P:positive regulation of attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071459">
        <property type="term" value="P:protein localization to chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990976">
        <property type="term" value="P:protein transport along microtubule to mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000127658" description="DASH complex subunit DAM1">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9HDZ6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="307" mass="34876" checksum="3E9B94EA698048A2" modified="2004-07-19" version="1">MSQDIRKEDGVRSATEYKLSMSSNPGSRRSSMADAESFNDDNMVLKNDVLREYLLPQIKDLTDSVVTLDSNMTRLNFIHDNLVDLNESFGSLLYGLMCNSWCVEFPNAPTRFDKEIRLMNEIEELSAEKSKLKSRLNSLREKPNAQTSDEKMKKPSGISQPIFQKPNVRRPRNALNDENLHKFNRENPPVYDDKREADEDTNSEASFVSNPANSKDMQLFANGSSNNDPKSRLRRKSILHTIRNSIASTSDAYDRKKQQGIQMGRVSLGGGAARVVSGRNMFEQQRTTRHSTTGIPNRVVKKRPPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLB9</accession>
    <name>Q6FLB9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">M7GpppX diphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0L04598g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms heterodimer with DCS2; the interaction inhibits the DCS1 scavenger decapping activity during post-diauxic growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLB9"/>
    <dbReference type="FunCoup" id="Q6FLB9">
        <property type="interactions" value="867"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLB9"/>
    <dbReference type="KEGG" id="cgr:2890645"/>
    <dbReference type="CGD" id="CAL0135762">
        <property type="gene designation" value="CAGL0L04598g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04598g"/>
    <dbReference type="eggNOG" id="KOG3969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041045_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FLB9"/>
    <dbReference type="OMA" id="PNTKWDG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031670">
        <property type="term" value="P:cellular response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.40:FF:000002">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000015">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
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        <ligand>
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            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="CAG61945.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="45201" checksum="43D0E681896B9235" modified="2004-07-19" version="1">MPTAMNTPPSSSEVYKNKIFRQEAGGVPTIEVEEEKWVPDAGSKNLAKLINEFRFERVLDSDPQTKKISLLGKIGGEDAILTCEKTHFMFEETVRRPSADGRSTPVFYHRENQYSCLTGIEGVQEISSNDIYYWGLSVIKQHLQKNPTAKLNLIYPATNIHIRRYDQQELHMVRETPEMYKKYVIPYIKKMTTSEMMKWVNNILYNGAEDHRIVYKHLDPHDEDGFLIFPDMKWDGVNLDALYLMAIVYREDIKSLRDLNSSHQEWLKKLNTTLRTIVPACFNYSIRPDELRIFVHYHPSFYHFHVHIVNVKHPGIGEEMGQGKTVLLDDIIETLNYLGPEGYMNRDLTYVIGENHSLWRHGFDRELDNQLKEDGIPRIPRSISNAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLF6</accession>
    <name>Q6FLF6_CANGA</name>
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        <recommendedName>
            <fullName evidence="5">Nucleoporin NUP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L03784g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
            <begin position="864"/>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0135834"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG61908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="93974" checksum="13732A3D24C20B6B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLH7</accession>
    <name>Q6FLH7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0L03333g</name>
    </gene>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
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                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QVEK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050744_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLH7"/>
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    <dbReference type="GO" id="GO:0030134">
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:D-mannose binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006888">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="lectin_leg-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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    <feature type="signal peptide" evidence="7">
        <location>
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            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274655" description="L-type lectin-like domain-containing protein" evidence="7">
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            <begin position="28"/>
            <end position="450"/>
        </location>
    </feature>
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        <location>
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            <end position="429"/>
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    </feature>
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            <begin position="178"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="450" mass="51181" checksum="67D6B05905C82712" modified="2004-07-19" version="1">MIAGGKSNVLVVVLICVLFGTFQLLMGTGELHSGGMGSVVRPEPENHRSNDRVRVKKVFNPDASLSVPFLDKINKYWHIGGTAEVRNMKSIMLTSAGQSGKHGVVLSNGIGDNTITDFEIVVDFRIYGREQRQSSHIGDGMAIVITPENGFLVRDLVSSFSRKQYEINSGGVHAKNVDLMGLPNNLPGLALVFDTYKNNYRTDVEIPYLDLILNTDPQKDMYSVNTDNLESTSKKLTPKHIKLHPSTIKGDITKLRIIYSETIGFLKVDIQYQKEGDYWIELYQSNEKIYLPKNKSSGQRFIGISALTGDATENVEILGVSTNEYHWNSNEREIQDSTTNDNLPRSYEYAQALKNYLLNEFGHRIALEKDDYTRWKMKMAQPNYENDLNDRVENQHVNNNKHQSKSSSRYIILLLFLVLIYISSVYIRVTKKHLRRLKRRRATSQTLLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLX1</accession>
    <name>Q6FLX1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0K12804g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLX1"/>
    <dbReference type="FunCoup" id="Q6FLX1">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLX1"/>
    <dbReference type="KEGG" id="cgr:2890428"/>
    <dbReference type="CGD" id="CAL0134857">
        <property type="gene designation" value="CAGL0K12804g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12804g"/>
    <dbReference type="eggNOG" id="KOG3408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117291_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLX1"/>
    <dbReference type="OMA" id="VNMLKFM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0134857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG61736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="172" mass="19735" checksum="876040F60EDA7BA0" modified="2004-07-19" version="1">MGRYSVKRYKTKRRTKDLDLIHEELKSQEKIQQLLNQPLDETKPGLGQHYCIHCAKYFETGIALKTHLKGKIHRRRVKELKSIPYTQEVADAAAGVNLNKFLNSVEKFKNVDNQVKETNETLLKEHLDQTLENIETTEPTLPWADNNKKSETTEPSTTSTAVEVATEAVMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM53</accession>
    <name>Q6FM53_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0K10934g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM53"/>
    <dbReference type="STRING" id="284593.Q6FM53"/>
    <dbReference type="KEGG" id="cgr:2890079"/>
    <dbReference type="CGD" id="CAL0134197">
        <property type="gene designation" value="CAGL0K10934g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10934g"/>
    <dbReference type="eggNOG" id="KOG1102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005350_11_0_1"/>
    <dbReference type="InParanoid" id="Q6FM53"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="203"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="454"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0134197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="599" mass="69333" checksum="51FF2E997B6FBD0B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMH4</accession>
    <name>Q6FMH4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0K08030g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMH4"/>
    <dbReference type="KEGG" id="cgr:2890338"/>
    <dbReference type="CGD" id="CAL0134773">
        <property type="gene designation" value="CAGL0K08030g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08030g"/>
    <dbReference type="eggNOG" id="KOG2238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012852_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FMH4"/>
    <dbReference type="OMA" id="MDKEDWY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21675">
        <property type="entry name" value="SMP_TEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF19">
        <property type="entry name" value="NUCLEUS-VACUOLE JUNCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="292"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="512"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="618"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
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        <location>
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            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
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            <end position="681"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0134773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61533.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="758" mass="85755" checksum="42790C178A17424E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMT5</accession>
    <name>Q6FMT5_CANGA</name>
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        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
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        <name evidence="7" type="primary">VMA13</name>
        <name evidence="7 8" type="ordered locus">CAGL0K05379g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
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        <property type="protein sequence ID" value="CAG61420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG2759">
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        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="6">
        <location>
            <begin position="377"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="505" mass="58038" checksum="795BE56C8C436FA7" modified="2004-07-19" version="1">MIGDTRLLLDSIHFNEMRSVIRSRSVAWEALSRSEEISDEEATYAKLVENVLVKKSVDSKELNVNENLIRSLVQLVGNTHNKDCRKSSLNLVAELLSSETHYKQTVEVFQEDKQLMRDLFQNSFQSEQEINDSQFTLIAAFNMVSLLTQESLQDSKLVEELLTVSDGLLLKILTNLQELDTSYVCIRLLQELAVHKGYKLIIWKYESQILPTLFTILRRAIDTKHKNTPLGFSSSTSTSSNSSHSFHRSASSALVPNANNLVIQIQYYSLLLIWVLMFERKVQKEYVTKYLTEYLNLLKIMKVTIKEKISRVSISILLQCLVDENGEVKDKKLIKQLLLLGNALPVVESLTERKYTDQELKDDLVLLKDILEQEYKELTSFDEYIAEVDSKLLCWSPPHIDNGFWVDNIDKFKLNNWELFKKLINILEDIKRDTNVDINESKTKTIIEVALSDIAHVVELLPESIDVLGKTGGKLLIMELLNHSDSRVKYEALKATQAIIGYRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMU4</accession>
    <name>Q6FMU4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha,alpha-trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ATH1</name>
        <name evidence="14 15" type="ordered locus">CAGL0K05137g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448450.1">
        <property type="nucleotide sequence ID" value="XM_448450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMU4"/>
    <dbReference type="FunCoup" id="Q6FMU4">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMU4"/>
    <dbReference type="CAZy" id="GH65">
        <property type="family name" value="Glycoside Hydrolase Family 65"/>
    </dbReference>
    <dbReference type="GeneID" id="2890507"/>
    <dbReference type="KEGG" id="cgr:2890507"/>
    <dbReference type="CGD" id="CAL0134431">
        <property type="gene designation" value="ATH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05137g"/>
    <dbReference type="eggNOG" id="KOG4125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006285_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FMU4"/>
    <dbReference type="OMA" id="DIALAHW"/>
    <dbReference type="PHI-base" id="PHI:10882"/>
    <dbReference type="PHI-base" id="PHI:11137"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030287">
        <property type="term" value="C:cell wall-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015771">
        <property type="term" value="P:trehalose transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000032">
        <property type="entry name" value="Vacuolar acid trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="entry name" value="Glycoside hydrolase, family 65, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="GH65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11051:SF8">
        <property type="entry name" value="PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0574">Periplasm</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 N-terminal" evidence="13">
        <location>
            <begin position="176"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 central catalytic" evidence="11">
        <location>
            <begin position="509"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 65 C-terminal" evidence="12">
        <location>
            <begin position="885"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0134431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG61411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1212" mass="136562" checksum="865C7C61BA37C7E6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN06</accession>
    <name>DLT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DLT1</name>
        <name type="ordered locus">CAGL0K03751g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DLT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448388.1">
        <property type="nucleotide sequence ID" value="XM_448388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN06"/>
    <dbReference type="FunCoup" id="Q6FN06">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN06"/>
    <dbReference type="EnsemblFungi" id="CAGL0K03751g-T">
        <property type="protein sequence ID" value="CAGL0K03751g-T-p1"/>
        <property type="gene ID" value="CAGL0K03751g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890138"/>
    <dbReference type="KEGG" id="cgr:2890138"/>
    <dbReference type="CGD" id="CAL0134465">
        <property type="gene designation" value="CAGL0K03751g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03751g"/>
    <dbReference type="eggNOG" id="ENOG502RAJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066044_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN06"/>
    <dbReference type="OMA" id="YESFQFS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000399020" description="Defect at low temperature protein 1">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="71"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="389" mass="44572" checksum="CFA884AEFAA1866A" modified="2004-07-19" version="1">MILQEQRRLRLWLYKSSLFISVLFLIGFSIVLPVDSIVQAIQSENNGFNTIIVIGSLAVFFVAAVTILIGRMLLHKSCLKDIPRRYIPVTNADLPHKSSRKMVIHNMERSKKLSGLFKTPKDPVIHPGLEPPARCDDPNTPKILPEYLNYKICIKSATDRLKYYGLFLNSASDDVKSSQTFTDLVKSQFIKGNHNKRQVQRAKDFIELYERIRFSGDEVSRSEFIQFAENCIYFSDLMITMDITKVGLGNISTRSQLSFNIAGSSVDRKLRKLNTARSNQISRLSSGQYPDITAFRYDTSNSDYHRQETDEDDFALDDMDYFPSVPPYMIRRNSTNTVSMRIPTSNSDDQYNLGFNEIGDEDIQNNDQIRRYMSNTSKTDSFKTVIHNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN17</accession>
    <name>Q6FN17_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HFD1</name>
        <name evidence="8 9" type="ordered locus">CAGL0K03509g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448377.1">
        <property type="nucleotide sequence ID" value="XM_448377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN17"/>
    <dbReference type="FunCoup" id="Q6FN17">
        <property type="interactions" value="508"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN17"/>
    <dbReference type="GeneID" id="2890178"/>
    <dbReference type="KEGG" id="cgr:2890178"/>
    <dbReference type="CGD" id="CAL0133859">
        <property type="gene designation" value="HFD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03509g"/>
    <dbReference type="eggNOG" id="KOG2456">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FN17"/>
    <dbReference type="OMA" id="KMFGDNP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018484">
        <property type="term" value="F:4-hydroxybenzaldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047770">
        <property type="term" value="F:carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046185">
        <property type="term" value="P:aldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="33"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0133859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="527" mass="59337" checksum="3D036832ED9AF20B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNC8</accession>
    <name>Q6FNC8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0K00957g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNC8"/>
    <dbReference type="FunCoup" id="Q6FNC8">
        <property type="interactions" value="1201"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNC8"/>
    <dbReference type="KEGG" id="cgr:2890150"/>
    <dbReference type="CGD" id="CAL0134059">
        <property type="gene designation" value="CAGL0K00957g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00957g"/>
    <dbReference type="eggNOG" id="KOG1063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006430_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNC8"/>
    <dbReference type="OMA" id="ENFRHIS"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="200"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="279"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="607"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="654"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="494"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0134059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG61227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="793" mass="89910" checksum="B69FC1C2D2DB9E6B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FND3</accession>
    <name>Q6FND3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Probable electron transfer flavoprotein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CIR1</name>
        <name evidence="9 10" type="ordered locus">CAGL0K00847g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </cofactor>
        <text evidence="7">Binds 1 AMP per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448261.1">
        <property type="nucleotide sequence ID" value="XM_448261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FND3"/>
    <dbReference type="FunCoup" id="Q6FND3">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FND3"/>
    <dbReference type="GeneID" id="2890196"/>
    <dbReference type="KEGG" id="cgr:2890196"/>
    <dbReference type="CGD" id="CAL0134851">
        <property type="gene designation" value="CIR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00847g"/>
    <dbReference type="eggNOG" id="KOG3180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FND3"/>
    <dbReference type="OMA" id="EINQPRI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294:SF8">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Electron transfer flavoprotein alpha/beta-subunit N-terminal" evidence="8">
        <location>
            <begin position="27"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="259" mass="28662" checksum="08775F873A2E5C59" modified="2004-07-19" version="1">MSKPLRILVPVKRVVDFQIKPRVNKTLTGIEKSGIKFSINPFDDIAVEETVRIKEKHGDLVEHTQAVSIGPAKAQDILRNCLAKGIDNVSLIDCKDLELEPLAVAKVLKNIVEKQNINLIIMGKQAIDDDFNHTGQMLAGLLNWPQATNAAKVDILADEGKVRITREIDGGEETLKASLPLIITTDLRLNTPRYVGLPNLMKAKKKPMEKLTLEKDFADIDTKPRLEILSVNEPNAKEPGITVGSVDELVQKLKDSKVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNF9</accession>
    <name>YRA2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>RNA annealing protein YRA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">YRA2</name>
        <name type="ordered locus">CAGL0K00253g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in export of poly(A) mRNAs from the nucleus. Recruited to the coding sequences as well as poly-A sites of active genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with mRNPs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YRA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448235.1">
        <property type="nucleotide sequence ID" value="XM_448235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNF9"/>
    <dbReference type="SMR" id="Q6FNF9"/>
    <dbReference type="FunCoup" id="Q6FNF9">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNF9"/>
    <dbReference type="EnsemblFungi" id="CAGL0K00253g-T">
        <property type="protein sequence ID" value="CAGL0K00253g-T-p1"/>
        <property type="gene ID" value="CAGL0K00253g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890535"/>
    <dbReference type="KEGG" id="cgr:2890535"/>
    <dbReference type="CGD" id="CAL0134553">
        <property type="gene designation" value="CAGL0K00253g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00253g"/>
    <dbReference type="eggNOG" id="ENOG502S444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111217_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNF9"/>
    <dbReference type="OMA" id="KQTAQEH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12295">
        <property type="entry name" value="RRM_YRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034396">
        <property type="entry name" value="Yra2_RRM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000409541" description="RNA annealing protein YRA2">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="40"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="168" mass="19922" checksum="DB85F2F0B123D41D" modified="2004-07-19" version="1">MSQNTKHHRVTNYRRRDLRNTLESRLGLPVEKRRLVPQLFRLKITNIGLDVSDYTILDIIKEFGEPEYINFRDHKDSRSCISDFKDNEIATKLIEKYNNFEINGKSIQVTLLDQQKRKRDADQERRKLRHGPRGGYGSHYTKSQKPIEQRNKTVDELNAELDAYMKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNM0</accession>
    <name>Q6FNM0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Golgi pH regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0J10626g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448174.1">
        <property type="nucleotide sequence ID" value="XM_448174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNM0"/>
    <dbReference type="FunCoup" id="Q6FNM0">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNM0"/>
    <dbReference type="KEGG" id="cgr:2889612"/>
    <dbReference type="CGD" id="CAL0132984">
        <property type="gene designation" value="CAGL0J10626g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10626g"/>
    <dbReference type="eggNOG" id="KOG2417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_498921_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNM0"/>
    <dbReference type="OMA" id="FRFNYQH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046528513" description="Golgi pH regulator" evidence="6">
        <location>
            <begin position="22"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="8">
        <location>
            <begin position="178"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="7">
        <location>
            <begin position="301"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0132984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="60772" checksum="EC69BEC6A4C3E2F0" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNP0</accession>
    <name>Q6FNP0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="7">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0J10186g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="7">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Eukaryotic pyruvate dehydrogenase (PDH) complexes are organized as a core consisting of the oligomeric dihydrolipoamide acetyl-transferase (E2), around which are arranged multiple copies of pyruvate dehydrogenase (E1), dihydrolipoamide dehydrogenase (E3) and protein X (E3BP) bound by non-covalent bonds.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="7"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNP0"/>
    <dbReference type="FunCoup" id="Q6FNP0">
        <property type="interactions" value="1198"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNP0"/>
    <dbReference type="KEGG" id="cgr:2889413"/>
    <dbReference type="CGD" id="CAL0133328">
        <property type="gene designation" value="CAGL0J10186g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10186g"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_1"/>
    <dbReference type="InParanoid" id="Q6FNP0"/>
    <dbReference type="OMA" id="TMEFESF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="35"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="10">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="128"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0133328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="469" mass="50212" checksum="5D3CC063E19F797E" modified="2004-07-19" version="1">MSALLRALPQVSRTALRGRLVTPMTLRLYASFPPHTVIGMPALSPTMSQGNLAVWSKKEGDSLAPGDVLAEIETDKAQMDFEFQDEGYLAKILVPAGTKDVAVSRPIAVYVEDEADVAAFKDFTVEDAGGSQSSSAPAAEEQKEEPKKEEVKEEKSEKKAAKSNSTPSSVASGDRIIASPLAKTIALEKGIALKSVKGTGPRGRITKADVEKYLESAPKSTSTAAPSATPSTTGGASYEDLEITNMRQIIGDRLLQSRQSIPSYIVSSDISVSKLLKLRKSLNATAKDQYKLSINDILIKAVTVAARRVPDANSYWLQNEGIIRQFKNVDVSVAVATPTGLLTPIVKNAESKGLIEISKEVKELASRAKINKLVPEEFQGGTICISNLGMNPAVSMFTSIINPPQSTILAIGTVKRVAVEDAGAENGIAFDDQVTITGTFDHRTIDGAKGADFMRELKTVIENPLQLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNX6</accession>
    <name>Q6FNX6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glyoxylate reductase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J08272g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNX6"/>
    <dbReference type="FunCoup" id="Q6FNX6">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNX6"/>
    <dbReference type="KEGG" id="cgr:2889925"/>
    <dbReference type="CGD" id="CAL0133714">
        <property type="gene designation" value="CAGL0J08272g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08272g"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FNX6"/>
    <dbReference type="OMA" id="VMDAAPS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047964">
        <property type="term" value="F:glyoxylate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009436">
        <property type="term" value="P:glyoxylate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000026">
        <property type="entry name" value="Glyoxylate/hydroxypyruvate reductase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF257">
        <property type="entry name" value="GLYOXYLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="25"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="124"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0133714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="38884" checksum="4E88C28108334BEC" modified="2004-07-19" version="1">MAKPIILRLGSLTFAQPQWKEVEEIADVITVDDSMTREQFLKELKNPESKLSKVSVITRTVGSASQTGLFDEEIAKALPDSVIAICHTGAGYDQIQVQYFKERHIQVANVPEIVSNATADTHVFLLLGALRNFAYGHHNILAGKWQEVTSAAETPFGYDPDGKTVAILGLGRIGRAIVDRLKPFGFGKFIYHNRHRLPEDEENGCEYVASIDDFYQQADVISINIPLNTHTKHLVNKEAFDKMKEGVVIVNTARGPVVDEKALIAALKSGKVRGAGLDVFEDEPHIPKELLELPQVLTTPHMGTHSVQTRWRMEKLVLDNAISALKTGKVITPVPEIQNDNWIEEIQPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNY0</accession>
    <name>Q6FNY0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0J08184g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448064.1">
        <property type="nucleotide sequence ID" value="XM_448064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNY0"/>
    <dbReference type="FunCoup" id="Q6FNY0">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNY0"/>
    <dbReference type="KEGG" id="cgr:2889921"/>
    <dbReference type="CGD" id="CAL0133096">
        <property type="gene designation" value="CAGL0J08184g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08184g"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="Q6FNY0"/>
    <dbReference type="OMA" id="MFAYLAV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="74"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0133096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="572" mass="63453" checksum="3CA44BADDC07D545" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP34</accession>
    <name>Q6FP34_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTPase-activating protein BEM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0J06996g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP34"/>
    <dbReference type="FunCoup" id="Q6FP34">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP34"/>
    <dbReference type="KEGG" id="cgr:2889629"/>
    <dbReference type="CGD" id="CAL0133666">
        <property type="gene designation" value="CAGL0J06996g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06996g"/>
    <dbReference type="eggNOG" id="KOG4269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010436_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP34"/>
    <dbReference type="OMA" id="QFISTDT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035024">
        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13277">
        <property type="entry name" value="PH_Bem3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="630"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="888"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0133666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1105" mass="123892" checksum="A444D7A5F8747546" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP40</accession>
    <name>Q6FP40_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Meiosis protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0J06864g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SFR1/MEI5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP40"/>
    <dbReference type="FunCoup" id="Q6FP40">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP40"/>
    <dbReference type="KEGG" id="cgr:2889555"/>
    <dbReference type="CGD" id="CAL0132820">
        <property type="gene designation" value="CAGL0J06864g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06864g"/>
    <dbReference type="eggNOG" id="ENOG502S2TF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084833_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP40"/>
    <dbReference type="OMA" id="AQMASNY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032798">
        <property type="term" value="C:Swi5-Sfr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018468">
        <property type="entry name" value="SFR1/Mei5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10376">
        <property type="entry name" value="Mei5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0132820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="25366" checksum="AE80B44D5CE28CCE" modified="2004-07-19" version="1">MEDTFIGDDTTLLESASQPGEKPSVKTVNNGKVLKPRNENIKRHRLILSEYRRKIRDEEKDIRELKQAIKIIEEKKLEHLMSLIEKWREVSQKTLSYMQYSTVLKIDKMGGFKKYMERELENKLLEIEDEYTRFEEEMGSFLESDEFERLSEEQQEEYKDQINSRRYDLEKLKLQKAKEIEKEYENVDDVFTLQELTKLLKIDYKLIFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP63</accession>
    <name>Q6FP63_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="11">1.1.99.39</ecNumber>
            <ecNumber evidence="17">1.1.99.40</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">D-lactate ferricytochrome C oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20 21" type="ordered locus">CAGL0J06314g</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-2-hydroxyglutarate + pyruvate = (R)-lactate + 2-oxoglutarate</text>
            <dbReference type="Rhea" id="RHEA:51608"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.40"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="11"/>
    <dbReference type="EC" id="1.1.99.40" evidence="17"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP63"/>
    <dbReference type="FunCoup" id="Q6FP63">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP63"/>
    <dbReference type="KEGG" id="cgr:2889585"/>
    <dbReference type="CGD" id="CAL0133542">
        <property type="gene designation" value="CAGL0J06314g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06314g"/>
    <dbReference type="eggNOG" id="KOG1232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FP63"/>
    <dbReference type="OMA" id="YNEDWMR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="19">
        <location>
            <begin position="111"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0133542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG60932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="543" mass="60492" checksum="FB357F99AE0A0246" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPB6</accession>
    <name>BTN1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein BTN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">BTN1</name>
        <name type="ordered locus">CAGL0J05104g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the battenin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPB6"/>
    <dbReference type="SMR" id="Q6FPB6"/>
    <dbReference type="FunCoup" id="Q6FPB6">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPB6"/>
    <dbReference type="EnsemblFungi" id="CAGL0J05104g-T">
        <property type="protein sequence ID" value="CAGL0J05104g-T-p1"/>
        <property type="gene ID" value="CAGL0J05104g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889499"/>
    <dbReference type="CGD" id="CAL0133534">
        <property type="gene designation" value="CAGL0J05104g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05104g"/>
    <dbReference type="eggNOG" id="KOG3880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029663_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FPB6"/>
    <dbReference type="OMA" id="WLCNWQV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903826">
        <property type="term" value="P:L-arginine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015819">
        <property type="term" value="P:lysine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000256258" description="Protein BTN1">
        <location>
            <begin position="30"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="411" mass="45826" checksum="6E7A50B81A0B2EF8" modified="2004-07-19" version="1" precursor="true">MNSKQRVYAFFWIFGLVNNVLYVVILSAAVDIVGPKVPKTLVLLMDITPSLLIKVTAPFFIKSIPYTMRIYALIALSCIGMIFVSGKSLLLCMIGIAMASVSSGFGEVSFLQLSHFFEENALNGWSSGTGGAGIVGSSVYMLLTSIFKLPIRLSLLSFTILPFAFLLYFKLDTTQIEYDSISSSGEETLIRNSNSNALQTDTFNESIRLSKTEEQNIFVSSIDHFKSTCVNLKALVVPYMLPLSSVYLFEYLINQAVSPTLLFPLDSRGLPPFFNKYRDMYVTYGTLYQLGVFISRSLAHKFRMHNLYFLSALQGLNLVLTILQAWIYIVHTPWPIMILIFYEGLLGGSSYVNTFLNVLEEVDMDKREFSLGAVSIADSLGVFIAALVGLGLEPTICNHQVSTGRPWCRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPB8</accession>
    <name>Q6FPB8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZAP1</name>
        <name evidence="10 11" type="ordered locus">CAGL0J05060g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447926.1">
        <property type="nucleotide sequence ID" value="XM_447926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPB8"/>
    <dbReference type="STRING" id="284593.Q6FPB8"/>
    <dbReference type="GeneID" id="2889568"/>
    <dbReference type="KEGG" id="cgr:2889568"/>
    <dbReference type="CGD" id="CAL0133356">
        <property type="gene designation" value="ZAP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05060g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014727_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPB8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001217">
        <property type="term" value="F:DNA-binding transcription repressor activity"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034224">
        <property type="term" value="P:cellular response to zinc ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000270"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000802">
        <property type="entry name" value="CCCTC-binding factor like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000032">
        <property type="entry name" value="Krueppel-like factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048420">
        <property type="entry name" value="Zap1-like_Znf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040792">
        <property type="entry name" value="Zap1_Znf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21816">
        <property type="entry name" value="Zap1_zf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18217">
        <property type="entry name" value="Zap1_zf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="534"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="499"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0133356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="713" mass="79445" checksum="EEA66F3AE8E93E6F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPC6</accession>
    <name>Q6FPC6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J04884g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447918.1">
        <property type="nucleotide sequence ID" value="XM_447918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPC6"/>
    <dbReference type="STRING" id="284593.Q6FPC6"/>
    <dbReference type="KEGG" id="cgr:2889560"/>
    <dbReference type="CGD" id="CAL0133456">
        <property type="gene designation" value="CAGL0J04884g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04884g"/>
    <dbReference type="eggNOG" id="KOG2689">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_847293_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPC6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="1">
        <location>
            <begin position="134"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="328" mass="38106" checksum="CC71AC6372F6B47D" modified="2004-07-19" version="1">MDVESLLWLSIRDSRRIIVTVTDEPMGELADECQIVRLSRDSGSFQRFVSVFNSSKTALYYYIEGPTVVEARSLDELKARFPNKNSTRPYESERQRIIDLINADKLERNSRSRQLSGYTALSSEVVLKDNIKNNKSDICTLKIRMTNGDYVQYDFDSNTSLGSVRRWLKDYRTDGDFPYLFHQNISRKSIRITEEYKTLAELDLTPRSILMLKQYDLRPRTRVPKPRKRSWYWQFLTVRIKRQLLEGLSEILASHRTTSNIMRSSSMSYLQADDSNMTKITNSLPPNDDNSEDIVKIKQKYNQNTGSIMNTPLEIARPDSPSVLQINT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPJ3</accession>
    <name>GET2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Golgi to ER traffic protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GET2</name>
        <name type="ordered locus">CAGL0J03366g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447851.1">
        <property type="nucleotide sequence ID" value="XM_447851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPJ3"/>
    <dbReference type="SMR" id="Q6FPJ3"/>
    <dbReference type="FunCoup" id="Q6FPJ3">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPJ3"/>
    <dbReference type="EnsemblFungi" id="CAGL0J03366g-T">
        <property type="protein sequence ID" value="CAGL0J03366g-T-p1"/>
        <property type="gene ID" value="CAGL0J03366g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889691"/>
    <dbReference type="KEGG" id="cgr:2889691"/>
    <dbReference type="CGD" id="CAL0133030">
        <property type="gene designation" value="GET2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03366g"/>
    <dbReference type="eggNOG" id="ENOG502QW0H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066477_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPJ3"/>
    <dbReference type="OMA" id="QYWDVLS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097051">
        <property type="term" value="P:establishment of protein localization to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03114">
        <property type="entry name" value="Get2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014802">
        <property type="entry name" value="GET2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000388628" description="Golgi to ER traffic protein 2">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="212"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="280" mass="31320" checksum="D96A256A509B3416" modified="2004-07-19" version="1">MSLSEAEKRKILRERRQQKFSRGGASERLNKIVGGQGSQLDTKSALDEKPEVVEEIPREAVKPEMNSSVQAKKESTAQAKAEDPQVELFRQLAEMQGQGATESTPDLFSMMKNLGATGDSPFPMAEQQVEAIDPELVEYHKYRVNTLTAKTTLVKWIVLLAYIFLLTRTDDTYFPFVVRSYLPEVFTSQSSFFSIFLTFEILATSIYYQLSVGVERETGVKTLQDTSKIVSLVSMVPEGILPIADLRGKVILAMKYWNIIAMMIGDVCFVLVAIGLVSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPL9</accession>
    <name>Q6FPL9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0J02794g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPL9"/>
    <dbReference type="FunCoup" id="Q6FPL9">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPL9"/>
    <dbReference type="KEGG" id="cgr:2889756"/>
    <dbReference type="CGD" id="CAL0132840">
        <property type="gene designation" value="CAGL0J02794g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02794g"/>
    <dbReference type="eggNOG" id="KOG3801">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120076_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FPL9"/>
    <dbReference type="OMA" id="YTTDKLV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="103" mass="11971" checksum="12B510000FDB63EC" modified="2004-07-19" version="1">MVARQQVLQLYKQIIKNANQFSNYNFREYFLRKARTEFKANKALTDAAKIESLFQGAQRDLGVLKRQSIISQMYTFDKLVVEPVEPVEPVEPVEPVEPVEPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPT5</accession>
    <name>Q6FPT5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0J01089g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPT5"/>
    <dbReference type="FunCoup" id="Q6FPT5">
        <property type="interactions" value="1224"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPT5"/>
    <dbReference type="KEGG" id="cgr:2889851"/>
    <dbReference type="CGD" id="CAL0132846">
        <property type="gene designation" value="CAGL0J01089g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01089g"/>
    <dbReference type="eggNOG" id="KOG3285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072097_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPT5"/>
    <dbReference type="OMA" id="WQFDVEI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990333">
        <property type="term" value="C:mitotic checkpoint complex, CDC20-MAD2 subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902499">
        <property type="term" value="P:positive regulation of protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="8"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0132846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="195" mass="22586" checksum="00BAB047C69CA6C0" modified="2004-07-19" version="1">MDRNLSLKGSTRSITEFFEYCINSILFQRGVYPPEDFSTVRKYELSLLRTHDDELKDYLRKILSQVHRWLLGGKCNKLVLCIVDKDDGEVVERWQFDVTHFSKEQETAAEVTDEETRNQMRTLIKQITASVTFLPELVKEGGYTFTVLAYTDADAKVPLEWGDSDSKEVKDGEIVQFRSFETNDHRVGAQVSYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPX7</accession>
    <name>Q6FPX7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">CAGL0I10989g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPX7"/>
    <dbReference type="FunCoup" id="Q6FPX7">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPX7"/>
    <dbReference type="KEGG" id="cgr:2889357"/>
    <dbReference type="eggNOG" id="KOG0838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FPX7"/>
    <dbReference type="OMA" id="RKYAHVH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="10">
        <location>
            <begin position="108"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="384" mass="43295" checksum="44A4929A14984C17" modified="2004-07-19" version="1">MSIRPAVKDGSPLKRRSVDRNIPVYKTSKAWERDGLDKDTWFRKKYAHVHADQKKRQKAGSLGKREAHEQRLDGICHSYRDNKNAHRQKFKNLYTNVTKFAINPLSEYLYGVNPILAALESDRRGYFTRLLHHDTNDKDSNKLTILRLCKEKGIKIDTADKHQLNLITKSAVHNNMVLECKPLSIPEINSLQNVNIDTASFNVLQTDGITQWSKSEKFHNNERKKYPVGIYLDEVTDPHNMGAIIRSAFFLGADFVALSRKNCAAIGPVVAKTSSGAVDYLPMFYVDKPLKFFELSQAEGWTVVSSSHGHSKKDVAKTLDLGDLHNMSHSMPILLVMGNEYSGIRTNLKQRSDFLVAIPQMTNNSTVDSLNVSVATGILLSKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPZ5</accession>
    <name>Q6FPZ5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0I10560g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPZ5"/>
    <dbReference type="FunCoup" id="Q6FPZ5">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPZ5"/>
    <dbReference type="KEGG" id="cgr:2889248"/>
    <dbReference type="CGD" id="CAL0132664">
        <property type="gene designation" value="CAGL0I10560g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I10560g"/>
    <dbReference type="eggNOG" id="ENOG502QQ4S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024075_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPZ5"/>
    <dbReference type="OMA" id="IVTCPNL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018843">
        <property type="entry name" value="Utp8_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053881">
        <property type="entry name" value="Utp8_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10395">
        <property type="entry name" value="Utp8_b_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22542">
        <property type="entry name" value="Utp8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Utp8 beta-propeller" evidence="2">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Utp8 C-terminal" evidence="3">
        <location>
            <begin position="407"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0132664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="678" mass="77014" checksum="C779D2FC0FC36294" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQA9</accession>
    <name>Q6FQA9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA mismatch repair protein Msh2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MSH2</name>
        <name evidence="14 15" type="ordered locus">CAGL0I07733g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447585.1">
        <property type="nucleotide sequence ID" value="XM_447585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQA9"/>
    <dbReference type="SMR" id="Q6FQA9"/>
    <dbReference type="FunCoup" id="Q6FQA9">
        <property type="interactions" value="1229"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQA9"/>
    <dbReference type="GeneID" id="2889005"/>
    <dbReference type="KEGG" id="cgr:2889005"/>
    <dbReference type="CGD" id="CAL0130205">
        <property type="gene designation" value="MSH2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07733g"/>
    <dbReference type="eggNOG" id="KOG0219">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_10_0_1"/>
    <dbReference type="InParanoid" id="Q6FQA9"/>
    <dbReference type="OMA" id="LVRFPQK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032302">
        <property type="term" value="C:MutSbeta complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000406">
        <property type="term" value="F:double-strand/single-strand DNA junction binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032137">
        <property type="term" value="F:guanine/thymine mispair binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000404">
        <property type="term" value="F:heteroduplex DNA loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032138">
        <property type="term" value="F:single base insertion or deletion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043570">
        <property type="term" value="P:maintenance of DNA repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006311">
        <property type="term" value="P:meiotic gene conversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000735">
        <property type="term" value="P:removal of nonhomologous ends"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000015">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000925">
        <property type="entry name" value="DNA mismatch repair protein MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000009">
        <property type="entry name" value="Mismatch repair ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="13">
        <location>
            <begin position="759"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0130205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="957" mass="107784" checksum="AAA040007E169994" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQC5</accession>
    <name>Q6FQC5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">INO4</name>
        <name evidence="8 9" type="ordered locus">CAGL0I07359g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447569.1">
        <property type="nucleotide sequence ID" value="XM_447569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQC5"/>
    <dbReference type="FunCoup" id="Q6FQC5">
        <property type="interactions" value="1450"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQC5"/>
    <dbReference type="GeneID" id="2889217"/>
    <dbReference type="KEGG" id="cgr:2889217"/>
    <dbReference type="CGD" id="CAL0132400">
        <property type="gene designation" value="INO4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07359g"/>
    <dbReference type="eggNOG" id="KOG3582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145552_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQC5"/>
    <dbReference type="OMA" id="IPQELIW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057072">
        <property type="entry name" value="bHLH_INO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23181">
        <property type="entry name" value="bHLH_INO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0132400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="129" mass="15246" checksum="0348507F4ECE8364" modified="2004-07-19" version="1">MKEENISGTETDASNTQSDTSGKLKKSTKRVSKKVKSNKLSEHEVRKNHVVSEQKRREIIRMMYDDLVQIVPDLSQKENRSELAIYIKTANYLRWLYEKNQELRMRIQEKHGDDKEIPQELIWNLKGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQC7</accession>
    <name>Q6FQC7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAGL0I07293g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAG60504.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="ENOG502QPQC">
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    </dbReference>
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    <dbReference type="InParanoid" id="Q6FQC7"/>
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        <property type="component" value="Chromosome I"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:fungal-type cell wall"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
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        <property type="entry name" value="Flocculin"/>
        <property type="match status" value="19"/>
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    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
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            <begin position="1"/>
            <end position="21"/>
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            <end position="329"/>
        </location>
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    </feature>
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            <begin position="1597"/>
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        </location>
    </feature>
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        <location>
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            <end position="1623"/>
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    </feature>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11765"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG60504.2"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1771" mass="191728" checksum="EFD6CB0F33D14CA5" modified="2008-09-23" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQD2</accession>
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        <recommendedName>
            <fullName evidence="6">HSF-type DNA-binding domain-containing protein</fullName>
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    </protein>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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        <name type="synonym">Nakaseomyces glabratus</name>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
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                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        <subcellularLocation>
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    </comment>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSF_DOMAIN"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="104"/>
        </location>
    </feature>
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        <location>
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            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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    </feature>
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    </feature>
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        </location>
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    </feature>
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            <end position="719"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="RuleBase" id="RU004020"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0132674"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG60499.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="771" mass="86304" checksum="B478FD612731F685" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQH6</accession>
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        <recommendedName>
            <fullName evidence="10">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="11" type="primary">PIR4</name>
        <name evidence="11 12" type="ordered locus">CAGL0I06160g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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            <taxon>Saccharomycotina</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQH6"/>
    <dbReference type="FunCoup" id="Q6FQH6">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQH6"/>
    <dbReference type="KEGG" id="cgr:2889374"/>
    <dbReference type="CGD" id="CAL0130163">
        <property type="gene designation" value="PIR4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06160g"/>
    <dbReference type="eggNOG" id="ENOG502RKR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039662_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FQH6"/>
    <dbReference type="OMA" id="NTMWSNN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000420">
        <property type="entry name" value="Yeast_PIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00399">
        <property type="entry name" value="PIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00929">
        <property type="entry name" value="PIR_REPEAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50256">
        <property type="entry name" value="PIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274785" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="10">
        <location>
            <begin position="149"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0130163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="233" mass="23842" checksum="28F779506D4E00A4" modified="2004-07-19" version="1">MQFKNVALTAAVASVAAADGYTPGNPWSTLTPSGTVACAKPEYTASFGIAVKPISSSVAKRAVVSQIGDGQIQATSAAPKPTNAAASQVADGQVQQKTTSTTKATTTLAPSSSKTSSTSTSTSCAATPLTIKESSCKNDGTLQLTLKGGVLTDGKGRVGSIVSNRQFQFDGPPPQAGAIYAGGWSITEQGNLALGNSDVFYQCLSGNFYNLYDQKIAEQCSPINLEVVSLVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQH8</accession>
    <name>Q6FQH8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SPS-sensor serine protease component SSY5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endoprotease SSY5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I06116g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protease component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Catalyzes the activation of these transcription factors, which are synthesized as latent cytoplasmic precursors, by proteolytic removal of an N-terminal inhibitory domain containing cytoplasmic retention motifs. SSY5 binds as an inactive protease complex to STP1. In response to extracellular amino acids and dependent on the other SPS-sensor components, the inhibitory propeptide is induced to dissociate, and thereby enables the catalytic domain to process STP1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S64 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQH8"/>
    <dbReference type="FunCoup" id="Q6FQH8">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQH8"/>
    <dbReference type="MEROPS" id="S64.001"/>
    <dbReference type="KEGG" id="cgr:2889371"/>
    <dbReference type="CGD" id="CAL0132092">
        <property type="gene designation" value="CAGL0I06116g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06116g"/>
    <dbReference type="eggNOG" id="ENOG502QR0D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012881_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQH8"/>
    <dbReference type="OMA" id="VGMLHSY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012985">
        <property type="entry name" value="Peptidase_S64_Ssy5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08192">
        <property type="entry name" value="Peptidase_S64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011716">
        <property type="entry name" value="Peptidase_S64_Ssy5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR011716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="680" mass="76231" checksum="C8735C86D17DB70D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2025-06-18" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQJ1</accession>
    <name>VPS27_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">VPS27</name>
        <name type="ordered locus">CAGL0I05830g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text>Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) which is required for the association to endosomal membranes.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Both IUM domains are necessary for efficient binding to ubiquitin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VPS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447503.1">
        <property type="nucleotide sequence ID" value="XM_447503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQJ1"/>
    <dbReference type="SMR" id="Q6FQJ1"/>
    <dbReference type="FunCoup" id="Q6FQJ1">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQJ1"/>
    <dbReference type="EnsemblFungi" id="CAGL0I05830g-T">
        <property type="protein sequence ID" value="CAGL0I05830g-T-p1"/>
        <property type="gene ID" value="CAGL0I05830g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889348"/>
    <dbReference type="KEGG" id="cgr:2889348"/>
    <dbReference type="CGD" id="CAL0132704">
        <property type="gene designation" value="VPS27"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05830g"/>
    <dbReference type="eggNOG" id="KOG1818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011862_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FQJ1"/>
    <dbReference type="OMA" id="HTWGGNT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140504">
        <property type="term" value="P:microlipophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903319">
        <property type="term" value="P:positive regulation of protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16979">
        <property type="entry name" value="VHS_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000039">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000292512" description="Vacuolar protein sorting-associated protein 27">
        <location>
            <begin position="1"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="VHS" evidence="4">
        <location>
            <begin position="18"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="UIM 1" evidence="3">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="UIM 2" evidence="3">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="FYVE-type; atypical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="452"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="603" mass="68711" checksum="095F5ECF6B9E51E9" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-13" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQT2</accession>
    <name>TCPD_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>T-complex protein 1 subunit delta</fullName>
            <shortName>TCP-1-delta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>CCT-delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CCT4</name>
        <name type="ordered locus">CAGL0I03762g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447412.1">
        <property type="nucleotide sequence ID" value="XM_447412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQT2"/>
    <dbReference type="SMR" id="Q6FQT2"/>
    <dbReference type="FunCoup" id="Q6FQT2">
        <property type="interactions" value="1542"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQT2"/>
    <dbReference type="EnsemblFungi" id="CAGL0I03762g-T">
        <property type="protein sequence ID" value="CAGL0I03762g-T-p1"/>
        <property type="gene ID" value="CAGL0I03762g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889151"/>
    <dbReference type="KEGG" id="cgr:2889151"/>
    <dbReference type="CGD" id="CAL0130482">
        <property type="gene designation" value="CAGL0I03762g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I03762g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03762g"/>
    <dbReference type="eggNOG" id="KOG0358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_9_1_1"/>
    <dbReference type="InParanoid" id="Q6FQT2"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000128340" description="T-complex protein 1 subunit delta">
        <location>
            <begin position="1"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="529" mass="57645" checksum="C7AE06D32C6016F8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQX5</accession>
    <name>COX23_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Cytochrome c oxidase-assembly factor COX23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">COX23</name>
        <name type="ordered locus">CAGL0I02728g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the COX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447369.1">
        <property type="nucleotide sequence ID" value="XM_447369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQX5"/>
    <dbReference type="SMR" id="Q6FQX5"/>
    <dbReference type="FunCoup" id="Q6FQX5">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQX5"/>
    <dbReference type="EnsemblFungi" id="CAGL0I02728g-T">
        <property type="protein sequence ID" value="CAGL0I02728g-T-p1"/>
        <property type="gene ID" value="CAGL0I02728g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889023"/>
    <dbReference type="KEGG" id="cgr:2889023"/>
    <dbReference type="CGD" id="CAL0132672">
        <property type="gene designation" value="CAGL0I02728g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02728g"/>
    <dbReference type="eggNOG" id="KOG4618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153383_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQX5"/>
    <dbReference type="OMA" id="NPENHRH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="3">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000280658" description="Cytochrome c oxidase-assembly factor COX23, mitochondrial">
        <location>
            <begin status="unknown"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="CHCH" evidence="4">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx9C motif 1" evidence="4">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx9C motif 2" evidence="4">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P38824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="111" mass="13439" checksum="06A2F519CBB1288B" modified="2004-07-19" version="1" precursor="true">MAADEDIIKDGNYDPHVQTDKDKVDYAPKGVDTTEYRYYPDNPESTLNKYRFAMKDHSQYYDPCQESAKMSFKCLELNDYDRDQCKEYFDAYRECKKQWLEARRKDRTNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR13</accession>
    <name>Q6FR13_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SKG6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I01848g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR13"/>
    <dbReference type="FunCoup" id="Q6FR13">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889108"/>
    <dbReference type="CGD" id="CAL0132186">
        <property type="gene designation" value="CAGL0I01848g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01848g"/>
    <dbReference type="eggNOG" id="ENOG502REX9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026020_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR13"/>
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    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902413">
        <property type="term" value="P:negative regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014805">
        <property type="entry name" value="SKG6/TOS2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08693">
        <property type="entry name" value="SKG6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="701" mass="77960" checksum="BED00D7EDF7A2E27" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRB4</accession>
    <name>Q6FRB4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein FMP23, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H09966g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FRB4">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888844"/>
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        <property type="gene designation" value="CAGL0H09966g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09966g"/>
    <dbReference type="eggNOG" id="ENOG502S3B9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1483131_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRB4"/>
    <dbReference type="OMA" id="GGHTFIF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035283">
        <property type="entry name" value="Fmp23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17315">
        <property type="entry name" value="FMP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0129585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21361" checksum="9315F4A8F7FC074D" modified="2004-07-19" version="1">MYWPLMRRALAKISYRPLVIARPSCRPYSKEVSSKIIIPPAGHFGEELNYAGAVVTKKSNIPMHEYRQLPDDSNYIEKYYAELDVFLQYLQTQLHKSYVDFENDPDELVFQLEKYIELQVRSNYDANKAGEKLVIDRFVAFCEGVKLTLWLNGGHCFIFDVLLQTKGEFDKLETTKKKQEIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRS8</accession>
    <name>Q6FRS8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Outer spore wall protein RRT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H06237g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRS8"/>
    <dbReference type="FunCoup" id="Q6FRS8">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888814"/>
    <dbReference type="CGD" id="CAL0129574">
        <property type="gene designation" value="CAGL0H06237g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06237g"/>
    <dbReference type="eggNOG" id="ENOG502QTNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062645_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FRS8"/>
    <dbReference type="OMA" id="YWATITP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF2">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34216" checksum="4E5E946801BB60D8" modified="2004-07-19" version="1">MSFAGSLILTGLGGVYYKFSRDQHFKPLEIAQKATIQDATSIYQRQLVKLATRSAQVSAVIADDLFTGNMFVYPFKGMYELYSNFRDYAASTTALFSLYLVSYAIVTMVYWATITPVYTALFIVLGPFGILIAWIHSILHTNMLTMMFLRVSHLNEGLVKNCVDANGYQSLFRHTPIKYQVSPSTPYFWYFHLTKKLSEYLTGLIILVFLLIISSIPIVGPFTFHFLVSPALSRVYFSKMLRLKGLSNIERYERIYQHPGQYTMFGITAGFLDSFPFLAGISLSTNILGATLLGIDQLTTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRT1</accession>
    <name>Q6FRT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein ATS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H06171g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRT1"/>
    <dbReference type="FunCoup" id="Q6FRT1">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRT1"/>
    <dbReference type="KEGG" id="cgr:2888515"/>
    <dbReference type="CGD" id="CAL0129467">
        <property type="gene designation" value="CAGL0H06171g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06171g"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005210_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRT1"/>
    <dbReference type="OMA" id="GWGANTK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="142"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="39324" checksum="9F4DCCA7E7597104" modified="2004-07-19" version="1">MIPIKSLDLPTDIDVTKISCGGNHTVILLSTGRVLGCGDNSLGQLCSDDQAKQIIGWKEICSGYNVIDVTCCWDSTTIVTADGKVYSRGSGLKGELGLGSSNLENKSNFELVMDCSKYAGYRVYSSFQNCILVLDKKEDNGSIVYAWGNNTKCQINEPKSRRLASPIVMYETFEIRVANVVMGKDFNLLMTPQGKIIHVNGKTPEDFTKDFETRWKFAKELEVKSMWSSIHIRDKSDPNKIHSYGNNIHGQVFDQSQLSPSECIANFTTGSEHGILVSKDRDHNDHELYQLSCWGWGEHGNCGSVQDHEEKQWVNDKHNVTSPLNPVAKAISRPMVYGGCATTWIVSNDTLAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS30</accession>
    <name>Q6FS30_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ACT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0H03905g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS30"/>
    <dbReference type="FunCoup" id="Q6FS30">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS30"/>
    <dbReference type="KEGG" id="cgr:2888632"/>
    <dbReference type="CGD" id="CAL0129534">
        <property type="gene designation" value="CAGL0H03905g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03905g"/>
    <dbReference type="eggNOG" id="KOG2663">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS30"/>
    <dbReference type="OMA" id="CARSGMM"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000001">
        <property type="entry name" value="Acetolactate synthase, small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="entry name" value="ACT-like. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054480">
        <property type="entry name" value="AHAS_small-like_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053050">
        <property type="entry name" value="ALS_regulatory_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31242:SF2">
        <property type="entry name" value="ACETOLACTATE SYNTHASE SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22629">
        <property type="entry name" value="ACT_AHAS_ss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="6">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0129534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="300" mass="33257" checksum="5F4619CF036DBBC2" modified="2004-07-19" version="1">MIRTVLSNSVKRSLVRHSSSSTSAMTYKQLHKHTARPPLPVVDTPAWDANSAVSSILYETPAPSRQPRKQHVLNCLVQNEPGVLSRISGTLAARGFNIDSLVVCNTEVKDLSRMTIVLKGQDGVIEQARRQIEDLIPVYAVLDYSNSEIIKRELVMARVSLLGSEYFEDLLVHHHKSTANLEDSHEIVSEIREKKFHPSNLQASEVLRLKHEHLNDITNLAKNFGGKIVDIGETSCIVELSAKPSRISAFLKLVEPFGVLECARSGMMALPRTPLQTEVDEEDIDGKISDIVDISQLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSI9</accession>
    <name>Q6FSI9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAGL0G10219g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSI9"/>
    <dbReference type="STRING" id="284593.Q6FSI9"/>
    <dbReference type="KEGG" id="cgr:2888103"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G10219g"/>
    <dbReference type="eggNOG" id="ENOG502SFJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_301275_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSI9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049451">
        <property type="entry name" value="AWP2-like_YTTT_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20646">
        <property type="entry name" value="Hpf1_C"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273536" evidence="2">
        <location>
            <begin position="20"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="802"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="834"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="877"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="916"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="992" mass="104287" checksum="A9CB9A7CD396D1BD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSK4</accession>
    <name>Q6FSK4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">THIF-type NAD/FAD binding fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G09889g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FSK4">
        <property type="interactions" value="1271"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSK4"/>
    <dbReference type="KEGG" id="cgr:2888138"/>
    <dbReference type="CGD" id="CAL0137607">
        <property type="gene designation" value="CAGL0G09889g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09889g"/>
    <dbReference type="eggNOG" id="KOG2014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002556_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FSK4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="1">
        <location>
            <begin position="12"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="336" mass="37780" checksum="64D569B38E17C406" modified="2004-07-19" version="1">MEKLSEDEIALYDRQIRLWGLAAQTNMRIAKVLLVNIGSIGTEVAKNIVLSGIGHLTVLDSHIVNETDLGSQFFLTANDVGKKRVEAVSDRLQDMNPRVNLVFDSADLKSKTDDFYKQFNIIIGTELDFFQRESLNSKCRALNIPLYLTGSNGMFAYIFVDLISFDAVDEKIHGNTSGVKLGSISERREIIKIDEREDDDRVMDIITTRNTYLPLSSILKSATLNGLLTNKQKKRATNILPLTFTQLKLTNPTNTEQFKEELLKTCKQLGLEFTTIKDDYLEQFIKQQGVEFTPVASVIGGAVAQDVINILGKRQSPLNNFIVFDGITLDMPIFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSS9</accession>
    <name>Q6FSS9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0G08107g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSS9"/>
    <dbReference type="STRING" id="284593.Q6FSS9"/>
    <dbReference type="KEGG" id="cgr:2888241"/>
    <dbReference type="CGD" id="CAL0130390">
        <property type="gene designation" value="CAGL0G08107g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08107g"/>
    <dbReference type="eggNOG" id="KOG0958">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_437415_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSS9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0130390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="625" mass="73310" checksum="3C140B1DD3C2E2A4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT46</accession>
    <name>Q6FT46_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G05467g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446598.1">
        <property type="nucleotide sequence ID" value="XM_446598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT46"/>
    <dbReference type="STRING" id="284593.Q6FT46"/>
    <dbReference type="KEGG" id="cgr:2888348"/>
    <dbReference type="CGD" id="CAL0129835">
        <property type="gene designation" value="CAGL0G05467g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05467g"/>
    <dbReference type="HOGENOM" id="CLU_698286_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT46"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="395" mass="44733" checksum="39B47B3B6A083819" modified="2004-07-19" version="1">MDEFNLDLFIIISFQMLIGGSNNAHNLQNNSTTHSANSGYNLSNRDPGSALSHYSGFHMSDGSPNSINSNLTNMTTPIFNSDNGTKFDDLYIISIFEKINNILVNSSSSSNLLRTFLNTLSVGSDTDYPNQLYKRFLGVRKELKDNYNESRFNQFFTANGDLRDYQTLEKNKTWSTIRNYILSIYDPIADKFLVPKSWTTNNSPRKMSVINNFTSSGMLSNLASNNNSNKDLVNYGSFFTNNKSLNGYYTQPTSPTPNDFSINFNLPITNNNNSNSNNSNNIPLPTGDEFDSAMVDMLDFPINTPVEEKFKRSEEPRSPVFVEEPPQDIVCSKSAQKALLALRQHYDGVISYNDEKIRKLEKELNEQRQESICLRKLLLEAMGSIRSTLNEMRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTC2</accession>
    <name>Q6FTC2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MAP2</name>
        <name evidence="13 14" type="ordered locus">CAGL0G03641g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446522.1">
        <property type="nucleotide sequence ID" value="XM_446522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTC2"/>
    <dbReference type="FunCoup" id="Q6FTC2">
        <property type="interactions" value="1239"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTC2"/>
    <dbReference type="MEROPS" id="M24.002"/>
    <dbReference type="GeneID" id="2888308"/>
    <dbReference type="KEGG" id="cgr:2888308"/>
    <dbReference type="CGD" id="CAL0130839">
        <property type="gene designation" value="CAGL0G03641g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03641g"/>
    <dbReference type="eggNOG" id="KOG2775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_1_1"/>
    <dbReference type="InParanoid" id="Q6FTC2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
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            <end position="304"/>
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        </location>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0130839"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG59449.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="415" mass="46611" checksum="2CB480384453D7BB" modified="2004-07-19" version="1">MSDEVAVPPVQEGEKVEAQVEEVAEEVVNEGGDSGKKKKNKKKKKKNNIKRIELIYPDEVYPEGEWMDYQQDFNLERTTDAEKRYLARDMEKQSEWNDVRKGAEIHRRVRKNVQNKLKPGMLLTEVADIIENATRKFTGAEDLTKMDNPVSQGIGFPTGLSLNHCAAHYTPNTGDKTVLKYEDVMKVDIGVQVNGHIVDSAWTVSFDPQYDNLLAAVKDATYTGIKEAGIDVRLTDIGEAIQEVMESYEVEIKGKTYQVKPCRNLCGHSIGPYTIHAGKSVPIVKNGDQTKMEEGEHFAIETFGTTGRGYVVSGGEVSHYARLPSDGLPQPNLASAKQLLKVIDDHFGTLPWCRRYLDRLGQDKYLFALNSLVKQGHVQDYPPLNDVIGSYTAQYEHTILLHPHKKEVVSKGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTF2</accession>
    <name>Q6FTF2_CANGA</name>
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            <fullName evidence="7">Protein NNF2</fullName>
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    </protein>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
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            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
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                <person name="Scarpelli C."/>
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            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome G"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR47357:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
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            <end position="51"/>
        </location>
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        </location>
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            <end position="879"/>
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            <end position="314"/>
        </location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0137741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="918" mass="104799" checksum="AE724B371966DC74" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTF8</accession>
    <name>Q6FTF8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0G02827g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
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    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of SLM1-SLM2. Binds phosphatidylinositol 4,5-bisphosphate, which is required for function. Interacts with the TORC2 subunits AVO2, BIT61 and TOR2. Interacts with the calcineurin catalytic subunits CNA1 and CNA2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTF8"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02827g"/>
    <dbReference type="eggNOG" id="ENOG502QRAF">
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        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046625">
        <property type="term" value="F:sphingolipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000328">
        <property type="entry name" value="Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000078">
        <property type="entry name" value="Slm1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="508"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="705"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="337"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="705"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00064463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0130833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="749" mass="85915" checksum="B164D40EA41FCC64" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTM9</accession>
    <name>KEX1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pheromone-processing carboxypeptidase KEX1</fullName>
            <ecNumber>3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Carboxypeptidase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">KEX1</name>
        <name type="ordered locus">CAGL0G01232g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446415.1">
        <property type="nucleotide sequence ID" value="XM_446415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTM9"/>
    <dbReference type="SMR" id="Q6FTM9"/>
    <dbReference type="FunCoup" id="Q6FTM9">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTM9"/>
    <dbReference type="ESTHER" id="canga-q6ftm9">
        <property type="family name" value="Carboxypeptidase_S10"/>
    </dbReference>
    <dbReference type="MEROPS" id="S10.007"/>
    <dbReference type="GlyCosmos" id="Q6FTM9">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0G01232g-T">
        <property type="protein sequence ID" value="CAGL0G01232g-T-p1"/>
        <property type="gene ID" value="CAGL0G01232g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888423"/>
    <dbReference type="KEGG" id="cgr:2888423"/>
    <dbReference type="CGD" id="CAL0130288">
        <property type="gene designation" value="CAGL0G01232g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01232g"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008523_11_2_1"/>
    <dbReference type="InParanoid" id="Q6FTM9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0053">Apoptosis</keyword>
    <keyword id="KW-0121">Carboxypeptidase</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000411910" description="Pheromone-processing carboxypeptidase KEX1">
        <location>
            <begin position="20"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="621"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="475"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="684"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="527"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="579"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="441"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="730" mass="83259" checksum="4033FFE7B7965132" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU27</accession>
    <name>LYS1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName>SDH</shortName>
            <ecNumber>1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">LYS1</name>
        <name type="ordered locus">CAGL0F06875g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446267.1">
        <property type="nucleotide sequence ID" value="XM_446267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU27"/>
    <dbReference type="SMR" id="Q6FU27"/>
    <dbReference type="FunCoup" id="Q6FU27">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU27"/>
    <dbReference type="EnsemblFungi" id="CAGL0F06875g-T">
        <property type="protein sequence ID" value="CAGL0F06875g-T-p1"/>
        <property type="gene ID" value="CAGL0F06875g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887663"/>
    <dbReference type="KEGG" id="cgr:2887663"/>
    <dbReference type="CGD" id="CAL0130944">
        <property type="gene designation" value="CAGL0F06875g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06875g"/>
    <dbReference type="eggNOG" id="KOG0172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063085_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU27"/>
    <dbReference type="OMA" id="YFFFSHT"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000423">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0576">Peroxisome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000199011" description="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Microbody targeting signal" evidence="2">
        <location>
            <begin position="370"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>L-saccharopine</name>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>L-saccharopine</name>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-saccharopine</name>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>L-saccharopine</name>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>L-saccharopine</name>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="278"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>L-saccharopine</name>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="317"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="204"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="372" mass="41552" checksum="9A578085727C3F2D" modified="2004-07-19" version="1">MSVTLHLRGETKPLEHRAALTPTTVKHLIGKGFKIYVEESPQSIFKIDEYRRAGAIIVPFGSWISAPRDRIIIGLKEMPEEDKFPLVHEHIQFAHCYKDQAGWKDVLRRFINGNGTLYDLEFLEDDNGRRVAAFGFYAGFAGAALGLADWAFKQTHKDSEDLPAVSPYPNEKALIKDIGKAYKNALKTGAKKPKVLIIGALGRCGSGAIDFLKKVGLPEENIIKWDIQETSRGGPFPEIAASDIFINCIYLSKPIAPFINYELLNKPDRKLRTVVDVSADTTNPHNPIPIYNIATVFNKPTVKVNTSSGPKLSVISIDHLPSLLPREASEFFAHDLLPSLEQLPSRHVSPVWVRAEKLFNRHSARAIRESKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-03-08" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU41</accession>
    <name>AEP1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ATPase expression protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AEP1</name>
        <name type="ordered locus">CAGL0F06567g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for translation of the mitochondrial OLI1 transcript encoding subunit 9 of mitochondrial ATP synthase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446253.1">
        <property type="nucleotide sequence ID" value="XM_446253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU41"/>
    <dbReference type="SMR" id="Q6FU41"/>
    <dbReference type="FunCoup" id="Q6FU41">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0F06567g-T">
        <property type="protein sequence ID" value="CAGL0F06567g-T-p1"/>
        <property type="gene ID" value="CAGL0F06567g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887914"/>
    <dbReference type="KEGG" id="cgr:2887914"/>
    <dbReference type="CGD" id="CAL0131320">
        <property type="gene designation" value="CAGL0F06567g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06567g"/>
    <dbReference type="eggNOG" id="ENOG502RXUX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035453_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU41"/>
    <dbReference type="OMA" id="CKVEANE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031467">
        <property type="entry name" value="Aep1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17049">
        <property type="entry name" value="AEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000405600" description="ATPase expression protein 1, mitochondrial">
        <location>
            <begin position="31"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="505" mass="57936" checksum="18F1BE3873D27674" modified="2004-07-19" version="1" precursor="true">MSTSGTTKGIPIPLNIFKRKSIPFGRISRVTPKPEQLLHPFYRPGNVSSLGLCMKEGKPALLDSKSIIPSIVQNSKTGNPVLANCSLAFSSVQGVSTWLKQYENLRETRTTPFSTIPFPDLNRYLTSLPKSKVEIIEKAYTNLINNDGSHISKGIILELVHELSSDFELAVFSENILIFFLNDKVSKRSELACVLEAAFDLLDTHIDQPKTIYKFLMAFFAKYFEVPVQTDTDLNTLMVKLLMKLENKFHLESMYSKMVPELTEALFSFYTREGNLHEANIAINDLIKKGFIPKSEDIENYLTLINTKYPGHNSQDYMWRLFHIAHFEGLIQSSDHPNLLKFLVQNCRHREEIETVFTIVAKNKNSKILLEHLTAPVIDSISNMKMHRVPKSSLLSDYYKMMKFAFNNELSHQLKLLLLQGYITFGNFSMSAKIIEDNHLNLTVDIANKLIKIIKHNNKLFKGIDCPGFSEEALALFLECYIKPFEDELNQHSKKWLIRQQHYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU90</accession>
    <name>Q6FU90_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nonsense-mediated mRNA decay factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0F05379g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in nonsense-mediated mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU90"/>
    <dbReference type="FunCoup" id="Q6FU90">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU90"/>
    <dbReference type="KEGG" id="cgr:2887681"/>
    <dbReference type="CGD" id="CAL0131342">
        <property type="gene designation" value="CAGL0F05379g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05379g"/>
    <dbReference type="eggNOG" id="KOG2162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_295597_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU90"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF37">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR EBS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="4">
        <location>
            <begin position="88"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="234"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="805"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="958"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1023" mass="115592" checksum="041B7786A2CFA106" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV19</accession>
    <name>Q6FV19_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0E05434g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV19"/>
    <dbReference type="FunCoup" id="Q6FV19">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV19"/>
    <dbReference type="KEGG" id="cgr:2887319"/>
    <dbReference type="CGD" id="CAL0128864">
        <property type="gene designation" value="CAGL0E05434g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05434g"/>
    <dbReference type="eggNOG" id="ENOG502QU3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015811_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FV19"/>
    <dbReference type="OMA" id="YMADHFI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="766"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0128864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="816" mass="93022" checksum="E61D9FF691177E0F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVB2</accession>
    <name>Q6FVB2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0E03289g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVB2"/>
    <dbReference type="STRING" id="284593.Q6FVB2"/>
    <dbReference type="KEGG" id="cgr:2887276"/>
    <dbReference type="CGD" id="CAL0128684">
        <property type="gene designation" value="CAGL0E03289g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E03289g"/>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006715_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FVB2"/>
    <dbReference type="OMA" id="IANQSQW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="325"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="595"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="598"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="613"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="640"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0128684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="696" mass="78619" checksum="8A95E79AF265E9FA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVE4</accession>
    <name>Q6FVE4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHO85 cyclin PHO80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PHO80</name>
        <name evidence="1 2" type="ordered locus">CAGL0E02541g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445800.1">
        <property type="nucleotide sequence ID" value="XM_445800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVE4"/>
    <dbReference type="FunCoup" id="Q6FVE4">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVE4"/>
    <dbReference type="GeneID" id="2887478"/>
    <dbReference type="KEGG" id="cgr:2887478"/>
    <dbReference type="CGD" id="CAL0128812">
        <property type="gene designation" value="PHO80"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02541g"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061246_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FVE4"/>
    <dbReference type="OMA" id="NDSHNIH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990860">
        <property type="term" value="C:Pho85-Pho80 CDK-cyclin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050849">
        <property type="term" value="P:negative regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000085">
        <property type="entry name" value="Pho80p cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39271" checksum="62F8A503F1F15E4B" modified="2004-07-19" version="1">MTPQDAQINTDEEIPTIKLPRDFLKCPKGDLVILIARMLQFIIQINDSNIKENERKYGLTRFHSKIAPNISVFNYFTRLTKYSLLEHSVLLSAVYYIDLLSNVYPAFNLNSLTAHRFLLTATTIASKGLCDSFCTNTHYSKVGGVQCNELNVLENEFLRKVNYRIIPRDNNITFCKMEVQKNFFILPESIESDLAPSLRQGYSSISNAGYNVLTRYYYKIIEVVGKYSSSPDKTKKVNYDIDMPAKTLHEHQQNDAVKNCSNNNSNYQTASNNIPIPQTIPQNRPKRNFDTVEERHNIYIEEKSKMNTNGLAEKLTSSSYKKQITEDKKNQILDNSIYPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVL1</accession>
    <name>Q6FVL1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0E01045g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVL1"/>
    <dbReference type="FunCoup" id="Q6FVL1">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVL1"/>
    <dbReference type="KEGG" id="cgr:2887414"/>
    <dbReference type="CGD" id="CAL0128834">
        <property type="gene designation" value="CAGL0E01045g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01045g"/>
    <dbReference type="eggNOG" id="ENOG502RZ32">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069841_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FVL1"/>
    <dbReference type="OMA" id="PFYLTHM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071852">
        <property type="term" value="P:fungal-type cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000283">
        <property type="entry name" value="NAP1-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="94"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0128834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG58652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="213" mass="23833" checksum="325604E3A9182E2E" modified="2004-07-19" version="1">MVENTDSTHGDAVNPGPEGEAVEVVDDLHSYISIKDYAYDESNALHYGYLEEEVPGEAVQEHDNYAGSDAEDGEDIDGNHTDKRASVVMPQDYVVNQKAVALYDFEPENDNELGLKEGDVIFISYRHCQGWLVAQNDTQTKTGLVPEEFVSYLDSEESDSVRPFYLTEMLTHGLQAEPEQDAKAGKKDDDEDEWEDIDQLESDMDSKLNISVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVL2</accession>
    <name>CWC15_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor CWC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CWC15</name>
        <name type="ordered locus">CAGL0E01023g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CWC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445732.1">
        <property type="nucleotide sequence ID" value="XM_445732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVL2"/>
    <dbReference type="FunCoup" id="Q6FVL2">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVL2"/>
    <dbReference type="EnsemblFungi" id="CAGL0E01023g-T">
        <property type="protein sequence ID" value="CAGL0E01023g-T-p1"/>
        <property type="gene ID" value="CAGL0E01023g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887413"/>
    <dbReference type="KEGG" id="cgr:2887413"/>
    <dbReference type="CGD" id="CAL0129014">
        <property type="gene designation" value="CAGL0E01023g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01023g"/>
    <dbReference type="eggNOG" id="KOG3228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1805920_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVL2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000218238" description="Pre-mRNA-splicing factor CWC15">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="143" mass="15695" checksum="933DA7FCAD95C974" modified="2004-07-19" version="1">MTTAHRPQLEARNGAKGALVPTGTEHARLLPGHTELKARKPKNKTTSQIQTSSDAGSVDDSTSAGTNIGTGSATLGPSQVQKMIQPLEVEDKKDIKLVKKEDDSVSWGKTAFSRRKKVVKPEKFTNDTVRSQKHKEFLNRFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVL5</accession>
    <name>Q6FVL5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0E00957g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVL5"/>
    <dbReference type="FunCoup" id="Q6FVL5">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVL5"/>
    <dbReference type="KEGG" id="cgr:2887359"/>
    <dbReference type="CGD" id="CAL0129084">
        <property type="gene designation" value="CAGL0E00957g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00957g"/>
    <dbReference type="eggNOG" id="KOG2347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_339546_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVL5"/>
    <dbReference type="OMA" id="RMWMDVD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001927">
        <property type="term" value="P:exocyst assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="84"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0129084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="981" mass="112874" checksum="4659D170F32E4FE6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVX2</accession>
    <name>Q6FVX2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0D04840g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445622.1">
        <property type="nucleotide sequence ID" value="XM_445622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVX2"/>
    <dbReference type="KEGG" id="cgr:2886974"/>
    <dbReference type="CGD" id="CAL0128257">
        <property type="gene designation" value="CAGL0D04840g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D04840g"/>
    <dbReference type="HOGENOM" id="CLU_1390039_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVX2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="196" mass="22164" checksum="32FB8DB50173DBC4" modified="2004-07-19" version="1">MIVAFHLRSCREFAVFECIYRELQRVCGVEYMSVQRSVWAPFSRHDHATLQAVLPGENEVLSEVIPRISGVDVTGGPQDADLHSIARDLAAGETPKGTLFRFTDHIQYMRMKETLETGYYRKHYIAPLLKSHLKSHLKSNPSTTVPIVTQLATHPSDIPPQMAKYIRGMDVTTEMTKKDRDTLDSLLYGGIDGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW19</accession>
    <name>Q6FW19_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">[NU+] prion formation protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0D03674g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW19"/>
    <dbReference type="FunCoup" id="Q6FW19">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW19"/>
    <dbReference type="KEGG" id="cgr:2887203"/>
    <dbReference type="CGD" id="CAL0128197">
        <property type="gene designation" value="CAGL0D03674g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03674g"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002848_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FW19"/>
    <dbReference type="OMA" id="EDHRKFG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008079">
        <property type="term" value="F:translation termination factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="NEW1_HB"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NEW1_HB"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
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    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="563"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="805"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="935"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1118"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1149"/>
            <end position="1159"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0128197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58486.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1186" mass="132692" checksum="73F5F65B6FC707A3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW55</accession>
    <name>Q6FW55_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0D02838g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG58450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="284593.Q6FW55"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02838g"/>
    <dbReference type="eggNOG" id="KOG0733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_8_3_1"/>
    <dbReference type="InParanoid" id="Q6FW55"/>
    <dbReference type="OMA" id="GLWSTHR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19518">
        <property type="entry name" value="RecA-like_NVL_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000110">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000156">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
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    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="231"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="565"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0128129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="834" mass="92221" checksum="8042C9BF73F2CF1C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2025-06-18" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWL5</accession>
    <name>SODC_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="3">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SOD1</name>
        <name type="ordered locus">CAGL0C04741g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="2">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445379.1">
        <property type="nucleotide sequence ID" value="XM_445379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWL5"/>
    <dbReference type="SMR" id="Q6FWL5"/>
    <dbReference type="FunCoup" id="Q6FWL5">
        <property type="interactions" value="853"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWL5"/>
    <dbReference type="EnsemblFungi" id="CAGL0C04741g-T">
        <property type="protein sequence ID" value="CAGL0C04741g-T-p1"/>
        <property type="gene ID" value="CAGL0C04741g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886862"/>
    <dbReference type="KEGG" id="cgr:2886862"/>
    <dbReference type="CGD" id="CAL0127282">
        <property type="gene designation" value="SOD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_C04741g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04741g"/>
    <dbReference type="eggNOG" id="KOG0441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056632_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FWL5"/>
    <dbReference type="OMA" id="AQRGFHI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902693">
        <property type="term" value="C:superoxide dismutase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016670">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901856">
        <property type="term" value="P:negative regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0049">Antioxidant</keyword>
    <keyword id="KW-0186">Copper</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="initiator methionine" description="Removed" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000164113" description="Superoxide dismutase [Cu-Zn]">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="58"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P85978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="154" mass="15750" checksum="3F2BE605B7AE55E2" modified="2007-01-23" version="3">MVKAVAVLRGSAGVSGVVTLEQASEQDPTTITYEIAGNDPNAERGFHIHEFGDVTNGCVSAGPHFNPFKKTHGAPQDENRHVGDLGNIKTDAQGVAKGVITDSLVKLIGPTSVVGRSVVVHAGTDDLGKGGNEESLKTGNAGPRPACGVIGLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWX2</accession>
    <name>Q6FWX2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Crh-like protein</fullName>
            <ecNumber evidence="14">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">UTR2</name>
        <name evidence="19 20" type="ordered locus">CAGL0C02211g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="14"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445272.1">
        <property type="nucleotide sequence ID" value="XM_445272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWX2"/>
    <dbReference type="SMR" id="Q6FWX2"/>
    <dbReference type="FunCoup" id="Q6FWX2">
        <property type="interactions" value="451"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWX2"/>
    <dbReference type="CAZy" id="CBM18">
        <property type="family name" value="Carbohydrate-Binding Module Family 18"/>
    </dbReference>
    <dbReference type="CAZy" id="GH16">
        <property type="family name" value="Glycoside Hydrolase Family 16"/>
    </dbReference>
    <dbReference type="GeneID" id="2886767"/>
    <dbReference type="KEGG" id="cgr:2886767"/>
    <dbReference type="CGD" id="CAL0127378">
        <property type="gene designation" value="UTR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02211g"/>
    <dbReference type="eggNOG" id="ENOG502QVQI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040459_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWX2"/>
    <dbReference type="OMA" id="NTFSEWH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000144">
        <property type="term" value="C:cellular bud neck septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006030">
        <property type="term" value="P:chitin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06923">
        <property type="entry name" value="ChtBD1_GH16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000159">
        <property type="entry name" value="Glycosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274265" description="Crh-like protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="18">
        <location>
            <begin position="25"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="352"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="359"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0127378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG58178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="481" mass="52445" checksum="5BB475FB0C602C9F" modified="2004-07-19" version="1">MLFLISLLSLFANILSVEAAELTAPIYCNATSQCPEEFPCCSQFGQCGTGQYCINNCNPKFSFSIDSCVPMPVCKDSSTKFDDYSSKVLNADTYLNNASAADWTYSGYLVDYPDEDSMILAMPKNSGGSVLSTTRYMWYGKVSARLKSSHLGGVVSSMILFSNVQDEIDIEFIGADLNTVQTNFYWEGTLNYTNSANMTTSNTFENYHDYEIDWHEDYITWSIDGVVGRTLYKNQTYNETTGIYEFPQTPSRIQISIWPGGNATSAPGTIAWAGGAINWDAPDIQDPGYYYMMVQEANITCYDPPANVKKNGTKSYIYTSNKDFTQDSIMISDKDFVLENSAWTGLNLTEGAKAKPSEAKASSKLSSSHNSTSSASSTSFHNSTSSTMHHNSTLTSITSKFSNSTSQSSTKHASTTSKTSERKSTASKTDPSTLQTTTKSSQSSSTSTSTIRNQKDSNTGAITKLNGLCAIIVAILTALLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWX5</accession>
    <name>Q6FWX5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAGL0C02145g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWX5"/>
    <dbReference type="FunCoup" id="Q6FWX5">
        <property type="interactions" value="808"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWX5"/>
    <dbReference type="KEGG" id="cgr:2886955"/>
    <dbReference type="eggNOG" id="KOG2073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003676_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FWX5"/>
    <dbReference type="OMA" id="SDYDLNC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF14">
        <property type="entry name" value="SIT4-ASSOCIATING PROTEIN SAP155-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="777" mass="89521" checksum="3F338223CB308A5F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX53</accession>
    <name>Q6FX53_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Purine-cytosine permease FCY2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0C00231g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445191.1">
        <property type="nucleotide sequence ID" value="XM_445191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX53"/>
    <dbReference type="KEGG" id="cgr:2886753"/>
    <dbReference type="CGD" id="CAL0127306">
        <property type="gene designation" value="CAGL0C00231g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00231g"/>
    <dbReference type="eggNOG" id="ENOG502QQ8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FX53"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015856">
        <property type="term" value="P:cytosine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11484">
        <property type="entry name" value="SLC-NCS1sbd_CobB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0127306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="59961" checksum="F70C6A820601EC39" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXA0</accession>
    <name>Q6FXA0_CANGA</name>
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        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0B01595g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="KEGG" id="cgr:2886580"/>
    <dbReference type="CGD" id="CAL0127834">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01595g"/>
    <dbReference type="eggNOG" id="ENOG502RPE4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_391916_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXA0"/>
    <dbReference type="OMA" id="LWQCYLL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0127834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG57939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="83538" checksum="3BAB01764EBE06DA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXA9</accession>
    <name>Q6FXA9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NOP8</name>
        <name evidence="7 8" type="ordered locus">CAGL0B01397g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445030.1">
        <property type="nucleotide sequence ID" value="XM_445030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXA9"/>
    <dbReference type="FunCoup" id="Q6FXA9">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXA9"/>
    <dbReference type="GeneID" id="2886502"/>
    <dbReference type="KEGG" id="cgr:2886502"/>
    <dbReference type="CGD" id="CAL0126980">
        <property type="gene designation" value="NOP8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01397g"/>
    <dbReference type="eggNOG" id="ENOG502QQ4K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020873_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FXA9"/>
    <dbReference type="OMA" id="TKLWGYE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008428">
        <property type="term" value="F:ribonuclease inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12226">
        <property type="entry name" value="RRM_NOL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034138">
        <property type="entry name" value="NOP8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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            <end position="83"/>
        </location>
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            <end position="328"/>
        </location>
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        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0126980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG57930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="514" mass="59384" checksum="7BF8841DF55F4C1B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXB9</accession>
    <name>Q6FXB9_CANGA</name>
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            <fullName evidence="6">Protein SKG6</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3 4" type="ordered locus">CAGL0B02145g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026020_0_0_1"/>
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    <dbReference type="OMA" id="NAINFRV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014805">
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    </dbReference>
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        <property type="entry name" value="SKG6"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="97"/>
        </location>
    </feature>
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            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="253"/>
        </location>
    </feature>
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        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
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        <location>
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            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="139"/>
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    </feature>
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            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0127896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG57963.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="69104" checksum="4E967DDE669F9389" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXD3</accession>
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        <recommendedName>
            <fullName evidence="8">Translation machinery-associated protein 64</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5 6" type="ordered locus">CAGL0B01837g</name>
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    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF2D family.</text>
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    <dbReference type="STRING" id="284593.Q6FXD3"/>
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    </dbReference>
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        <property type="entry name" value="eukaryotic translation initiation factor 2D"/>
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        <property type="entry name" value="PUA-like_sf"/>
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    <dbReference type="InterPro" id="IPR048248">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="476"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010359"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0127710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG57949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64490" checksum="D4A3C2CEBEA382CA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXE5</accession>
    <name>Q6FXE5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic sister chromatid recombination protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">GIN3</name>
        <name evidence="2 3" type="ordered locus">CAGL0B02563g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXE5"/>
    <dbReference type="FunCoup" id="Q6FXE5">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXE5"/>
    <dbReference type="KEGG" id="cgr:2886696"/>
    <dbReference type="CGD" id="CAL0127776">
        <property type="gene designation" value="GIN3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B02563g"/>
    <dbReference type="eggNOG" id="ENOG502RNIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028751_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXE5"/>
    <dbReference type="OMA" id="PFYKRWY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990166">
        <property type="term" value="P:protein localization to site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274953" description="Meiotic sister chromatid recombination protein 1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG57982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="59428" checksum="B50AAE5FB3ADCC37" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXT0</accession>
    <name>Q6FXT0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein SKT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SKT5</name>
        <name evidence="4 5" type="ordered locus">CAGL0A04411g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444959.1">
        <property type="nucleotide sequence ID" value="XM_444959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXT0"/>
    <dbReference type="FunCoup" id="Q6FXT0">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXT0"/>
    <dbReference type="GeneID" id="2886390"/>
    <dbReference type="KEGG" id="cgr:2886390"/>
    <dbReference type="CGD" id="CAL0126659">
        <property type="gene designation" value="SKT5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04411g"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_126_4_1"/>
    <dbReference type="InParanoid" id="Q6FXT0"/>
    <dbReference type="OMA" id="YEHGKGC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000707">
        <property type="entry name" value="Chitin synthase regulatory factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATOR SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="558"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0126659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG57852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="73348" checksum="B654C4C16F25CF48" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXT8</accession>
    <name>Q6FXT8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0A04829g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444978.1">
        <property type="nucleotide sequence ID" value="XM_444978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXT8"/>
    <dbReference type="FunCoup" id="Q6FXT8">
        <property type="interactions" value="583"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXT8"/>
    <dbReference type="KEGG" id="cgr:2886356"/>
    <dbReference type="CGD" id="CAL0126777">
        <property type="gene designation" value="CAGL0A04829g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04829g"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_2_1"/>
    <dbReference type="InParanoid" id="Q6FXT8"/>
    <dbReference type="OMA" id="ADCVQQF"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990539">
        <property type="term" value="P:fructose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24087">
        <property type="entry name" value="ASKHA_NBD_HK1-2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1250:FF:000001">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="227"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0126777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG57871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="486" mass="53806" checksum="775B3314FE65B2A4" modified="2004-07-19" version="1">MVHLGPKKPPTRKGSMVDMPQQLLDQIKVFEEMYTVDGETLRKVTKHFITELDKGLSKKGGNIPMIPGWVMEYPSGKEKGDYLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYKLPEAMRTTKNHEELWSFIADSLQAFLEDQFPEGVKGKLPLGFTFSYPASQDRINQGVLQRWTKGFDIPNVEGHDVVPMLQKQIEKRNLPIDIVALINDTTGTLVASLYTDGETKMGVIFGTGVNGAYYDVVSDIPKLEGKLADDIPNDSPMAINCEYGSFDNEHVVLPRNKYDLIIDEESPRPGQQAFEKMSSGYYLGEMLRLALLDLYDQGLILKGQDISKLKKPYVMDTSYPSKIEDDPFENLEDTDELLQKNLGIQTTVQERKLIRRLCELIGTRSARLSVCGIAAICQKRGYETAHIAADGSVFKMYPGFKEKAAQGLADIYGWEHKDPKDCPIVIVDAEDGSGAGAAIIAALAEKRIAEGKSLGVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXY0</accession>
    <name>Q6FXY0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0A00715g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444802.1">
        <property type="nucleotide sequence ID" value="XM_444802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXY0"/>
    <dbReference type="KEGG" id="cgr:2886372"/>
    <dbReference type="CGD" id="CAL0126691">
        <property type="gene designation" value="CAGL0A00715g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A00715g"/>
    <dbReference type="HOGENOM" id="CLU_2359491_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXY0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0126691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG57693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="96" mass="10542" checksum="FAA173D2EBFFCB6C" modified="2004-07-19" version="1">MSYSVETKKHVRGISDHILSEHKISTTPAITGMGPFTTAVRVSLSAIDDTVHYRSKVPDSTTPCNHGCFAGNMKGTSIVAERNLREVRMAHIIYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY85</accession>
    <name>Q6FY85_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0A04213g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
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                <person name="Thierry A."/>
                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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    </reference>
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        <text evidence="8">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
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        <text evidence="9">Interacts with csx1.</text>
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        <subcellularLocation>
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</entry>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
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                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
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                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
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                <person name="Scarpelli C."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50102"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0133114"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG60749.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
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</entry>
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            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] reductase FabG</fullName>
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    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
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            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIN5"/>
    <dbReference type="FunCoup" id="Q6FIN5">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIN5"/>
    <dbReference type="KEGG" id="cgr:2891199"/>
    <dbReference type="CGD" id="CAL0136311">
        <property type="gene designation" value="CAGL0M13013g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13013g"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_1"/>
    <dbReference type="InParanoid" id="Q6FIN5"/>
    <dbReference type="OMA" id="QETETWG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0136311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="29618" checksum="79DF5B793E68C900" modified="2004-07-19" version="1">MIEIPYAIVTGATGGVGKAIVRKLTREGVNCIAIGSSTDSITKKLRFGDDLLFTGAHHRNRAVALDLARWDGEFNHSAATIEGYIAEGNISTSNKELVLSNALAFDNNDSNRYTLRVLVNCAGITQASVGIRMSPNVISNMINVNFASAVYLSNYAARLQMKQKSRKRLDIINVSSILGGFADKRNFMIQGTSIYSATKAALSQFTRVYGKEVERLSINCHDIAPGLIPETDMIKNLPERAQENLLRTINGEITTVDEVSEQVLRIYKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIP0</accession>
    <name>Q6FIP0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SEC28</name>
        <name evidence="12 13" type="ordered locus">CAGL0M12903g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449904.1">
        <property type="nucleotide sequence ID" value="XM_449904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIP0"/>
    <dbReference type="FunCoup" id="Q6FIP0">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIP0"/>
    <dbReference type="GeneID" id="2891455"/>
    <dbReference type="KEGG" id="cgr:2891455"/>
    <dbReference type="CGD" id="CAL0136597">
        <property type="gene designation" value="SEC28"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M12903g"/>
    <dbReference type="eggNOG" id="KOG3081">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075638_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIP0"/>
    <dbReference type="OMA" id="SNFYYFE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006901">
        <property type="term" value="P:vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0136597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG62884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="295" mass="33041" checksum="7753DCC9CD24C9D9" modified="2004-07-19" version="1">MDYFTVKQSFYNGLYEKVLEEASKLGKVEDVTIKYYQLRSELALGQLKAGGDDSLSQAFALYETFLKDSKHDLSKLESHVKGKNCLYHLNLLASAQAIKGDVEESLKTCVEGIDSGNEVGVPDLLLLAIEVALLNNKASTASTMFENYTSTNADSLSSEDELIINLAESYIKFATNVDTSSSNFYHFEELAQTFPTWKSQLGLLNLQLQQGNTTEAQSIVDLLESEYYSKNLEAVQLYKGNFLANKITLAIMEGEKSKAEELRSELKQFVPNHGFNKSHEELTSKFDEIVVKYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIY3</accession>
    <name>Q6FIY3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">M-phase phosphoprotein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M10681g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIY3"/>
    <dbReference type="FunCoup" id="Q6FIY3">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891376"/>
    <dbReference type="CGD" id="CAL0136735">
        <property type="gene designation" value="CAGL0M10681g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M10681g"/>
    <dbReference type="HOGENOM" id="CLU_132767_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIY3"/>
    <dbReference type="OMA" id="FRDNSEW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17046" checksum="5098C92A7081A324" modified="2004-07-19" version="1">MSGKGELSSRVMNMKFMKFMRPEGQDNKDEGTSKHTHLDASKWDLKSSVNSDSTNKRRVVVKRASKALKIMENVGITSVKAEDDSNKSSALHGRRIFGENKNKRVAEEEEENKTEQEPKQEKDMDELFKESRRNTKPKKKSHKKHKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJB2</accession>
    <name>Q6FJB2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0M07678g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJB2"/>
    <dbReference type="FunCoup" id="Q6FJB2">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJB2"/>
    <dbReference type="KEGG" id="cgr:2891732"/>
    <dbReference type="CGD" id="CAL0136503">
        <property type="gene designation" value="CAGL0M07678g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07678g"/>
    <dbReference type="eggNOG" id="ENOG502S6Z4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024653_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJB2"/>
    <dbReference type="OMA" id="RFPHTKK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="111"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0136503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="473" mass="55438" checksum="362177B99C4024B2" modified="2004-07-19" version="1">MSKENLLLKLDRLEYQWHYLQETHEKFEPRFPFTQRFFNAKGKKNNKKVTKILESSDKEKVRSDLKEVRVEILNRKIHNVEKHVNNYLFKTIKSIVSNDKSVFQPVLEAVEAKYGAGDAGLHDFCEIVTKSKAIKFIISKLQKSSANIASANEEVSDKRIPKWAADHEYVKMWTDKNNKYNPSKVWNEDVTKIKSCDALISRVMNGKKYKQMMDQFDDSLDLFLNINKQKRLQKQQEKKKSTKTSSKQHEEENEDASGDDFGYSDNDDPRYNENIDEDELLKQYDGMLVGSDDESDEEEDSAKSSASEDETSERIGKQEPVPKLKKKEKAKLPELMVGYVSGGSDEEIEVDDIAKEQIEIKPQKKNRRGQRARRKIWEQKYGSKAKHVQREIEKEMEKKRKRQAEYEERVAKRAARAEQNEEYQAKKAEIKREKEEHRKKLEKIEDHPSWVAKKMAEDKEKNAKFAGKKITFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJE4</accession>
    <name>Q6FJE4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-phosphogluconolactonase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SOL2</name>
        <name evidence="7 8" type="ordered locus">CAGL0M06963g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449650.1">
        <property type="nucleotide sequence ID" value="XM_449650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJE4"/>
    <dbReference type="STRING" id="284593.Q6FJE4"/>
    <dbReference type="GeneID" id="2891699"/>
    <dbReference type="KEGG" id="cgr:2891699"/>
    <dbReference type="CGD" id="CAL0136339">
        <property type="gene designation" value="SOL2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06963g"/>
    <dbReference type="eggNOG" id="KOG3147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJE4"/>
    <dbReference type="OMA" id="IAMSQST"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="264" mass="30196" checksum="C852D7A1639E82CC" modified="2004-07-19" version="1">MTTAAPKLIQFDDEREVACATTEQIIKSQNSKLRQPVKKRTRRENRFRLAISGGQLMQTLLKALLYRKEEIEWEKWDIFFVDERLVPFNSNESNYGQLKRGLLDPLKSINYPQPNVYHIEETEIDDANVVAQTYEKQLINIFASRDSVRLPTFDMILLGCAPDGHIASLFPQCHHNLREEMAWVIPITDAPLEPTKRISMSVPVISNSNQIIFMVTGSNNAELMKMIIEKPSCELPSALISTCAPGRVSWYVENEALKEVMLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJM9</accession>
    <name>Q6FJM9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0M05005g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJM9"/>
    <dbReference type="FunCoup" id="Q6FJM9">
        <property type="interactions" value="587"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJM9"/>
    <dbReference type="KEGG" id="cgr:2891575"/>
    <dbReference type="CGD" id="CAL0136933">
        <property type="gene designation" value="CAGL0M05005g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05005g"/>
    <dbReference type="eggNOG" id="KOG3334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068315_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FJM9"/>
    <dbReference type="OMA" id="PHDAQVM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0136933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18366" checksum="A5D5AD4460E7E844" modified="2004-07-19" version="1">MEEVDSQGDLPRDVRLLHLLLASQSIQQYEDRVPLQLMDFAHRYTRGVLMDAMVYNDYASENAPGGSNAAANATNAKNAPKANTLGSGMTSNGGKNINVEDVRLAIAARTQYMFKPTAPKELLLQLAAERNKKALPQVMGSWGVRLPPEKYCLTAKSWDLDEKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJN7</accession>
    <name>Q6FJN7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0M04829g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FJN7">
        <property type="interactions" value="1310"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJN7"/>
    <dbReference type="KEGG" id="cgr:2891567"/>
    <dbReference type="CGD" id="CAL0136839">
        <property type="gene designation" value="CAGL0M04829g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04829g"/>
    <dbReference type="eggNOG" id="KOG1070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000845_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJN7"/>
    <dbReference type="OMA" id="GQYLRAY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034512">
        <property type="term" value="F:box C/D sno(s)RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
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        <location>
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            <end position="220"/>
        </location>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK19</accession>
    <name>Q6FK19_CANGA</name>
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        <recommendedName>
            <fullName evidence="4">Protein SLM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M01848g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_104687_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK19"/>
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    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
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    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="term" value="P:endocytic recycling"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="151" mass="16629" checksum="51E2E1925B329C9F" modified="2004-07-19" version="1">MIHSRNVQALLDGMLGGCDVLEGTVPVPALHSVALLSADTGSIISFSKEHDLEHGPAEHDSLNNLRIMALLVKDKFSSDEKKSCEKGYDLDGGHRAYTYDVEDLHASVTRIPDSDLLLMLLAHRDFPYGLLNMKLKACVKSFAQLYGYRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK65</accession>
    <name>Q6FK65_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SIR3</name>
        <name evidence="3 4" type="ordered locus">CAGL0M00770g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449379.1">
        <property type="nucleotide sequence ID" value="XM_449379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK65"/>
    <dbReference type="STRING" id="284593.Q6FK65"/>
    <dbReference type="GeneID" id="2891602"/>
    <dbReference type="KEGG" id="cgr:2891602"/>
    <dbReference type="CGD" id="CAL0137161">
        <property type="gene designation" value="SIR3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00770g"/>
    <dbReference type="eggNOG" id="KOG1514">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012774_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FK65"/>
    <dbReference type="OMA" id="SANTHYD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04720">
        <property type="entry name" value="BAH_Orc1p_Yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82061">
        <property type="entry name" value="BAH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="49"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1088" mass="123829" checksum="CF80CA44DDCC2D63" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK68</accession>
    <name>Q6FK68_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M00704g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449376.1">
        <property type="nucleotide sequence ID" value="XM_449376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK68"/>
    <dbReference type="KEGG" id="cgr:2891599"/>
    <dbReference type="CGD" id="CAL0136921">
        <property type="gene designation" value="CAGL0M00704g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00704g"/>
    <dbReference type="HOGENOM" id="CLU_966424_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK68"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0136921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="288" mass="33782" checksum="EDE09606E6F0E27B" modified="2004-07-19" version="1">MQTEVIIRNKVAVYKLIGLCQKYRDDVQNLHKCMLRLNSLFYKMTTEEIESQSKKNNDSSTTLIASATSDKCSNLNYNRCDEGLSACQVSPVENNLDEASPQDNDLLLRPKTYSAVMLDTAAISDDVRPLMESIRKDTPKKFHFYKNYGFHLGTLQDESRIIAQKLHYELKHISLKIIIPMKLFDKQCTHYLKHCPCGNKIVTPYEVKQVDKFIEYIPKFWHYWFLSYYSIFYRIHFLLYLQSCQLLLQKSRNTVINKSELSSISLLNDYREKAESIVRQMESFNFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK73</accession>
    <name>Q6FK73_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0M00594g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449371.1">
        <property type="nucleotide sequence ID" value="XM_449371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK73"/>
    <dbReference type="KEGG" id="cgr:2891594"/>
    <dbReference type="CGD" id="CAL0137441">
        <property type="gene designation" value="CAGL0M00594g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00594g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003977_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK73"/>
    <dbReference type="OMA" id="KYWENLY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
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        <location>
            <begin position="169"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0137441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1020" mass="114748" checksum="1E7532CAF47ED07B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKA6</accession>
    <name>Q6FKA6_CANGA</name>
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        <recommendedName>
            <fullName evidence="4">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NDT80</name>
        <name evidence="5 6" type="ordered locus">CAGL0L13090g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="cgr:2890588"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502R1FS">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015202_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKA6"/>
    <dbReference type="Proteomes" id="UP000002428">
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    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF2">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="33"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="33"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0136074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="748" mass="85106" checksum="81B1E844E35224A0" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKF1</accession>
    <name>Q6FKF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L12078g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKF1"/>
    <dbReference type="SMR" id="Q6FKF1"/>
    <dbReference type="FunCoup" id="Q6FKF1">
        <property type="interactions" value="704"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKF1"/>
    <dbReference type="KEGG" id="cgr:2890683"/>
    <dbReference type="CGD" id="CAL0136014">
        <property type="gene designation" value="CAGL0L12078g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12078g"/>
    <dbReference type="eggNOG" id="KOG0225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_2_1"/>
    <dbReference type="InParanoid" id="Q6FKF1"/>
    <dbReference type="OMA" id="LGYEMPC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="75"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="408" mass="44944" checksum="6D6692F497DB11C7" modified="2004-07-19" version="1">MLSIASKRPLALSARSVVGIGRTMATAKEKSQPVPDENENVEISLPETSFEGYMLEPPSLNYSATKGSLLQMFKDMVIIRRMEMACDALYKAKKIRGFCHLSVGQEAIAVGIENAITKRDSVITSYRCHGFTYMRGASVQAVLAELMGKRSGVSFGKGGSMHLFAPGFYGGNGIVGAQVPVGAGLAFAHQYKNEDACSFTLYGDGASNQGQVFESFNMAKLWNLPVVFCCENNKYGMGTAAARSSAMTEYFKRGQYIPGLKVNGMDILAVYQASKFAKEWCLSGKGPLVLEYETYRYGGHSMSDPGTTYRTRDEIQHMRSKNDPIAGLKMHLLELGIATEEEVKAYDKAARKYVDEQVELADKSAPPEAKLSILFEDVYVKGTETPTLRGRIPEDTWDFTKNDFLVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKF6</accession>
    <name>Q6FKF6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Checkpoint protein RAD24-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0L11968g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKF6"/>
    <dbReference type="FunCoup" id="Q6FKF6">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKF6"/>
    <dbReference type="KEGG" id="cgr:2890952"/>
    <dbReference type="CGD" id="CAL0135026">
        <property type="gene designation" value="CAGL0L11968g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11968g"/>
    <dbReference type="eggNOG" id="KOG1970">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027373_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKF6"/>
    <dbReference type="OMA" id="PREWKIR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="333"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="636"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="641"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0135026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="661" mass="75795" checksum="9386FE84D5A3A7EE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKF9</accession>
    <name>Q6FKF9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="7">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenylate kinase 3</fullName>
            <shortName evidence="7">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ADK2</name>
        <name evidence="10 11" type="ordered locus">CAGL0L11902g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="7"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449285.1">
        <property type="nucleotide sequence ID" value="XM_449285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKF9"/>
    <dbReference type="FunCoup" id="Q6FKF9">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKF9"/>
    <dbReference type="GeneID" id="2890949"/>
    <dbReference type="KEGG" id="cgr:2890949"/>
    <dbReference type="CGD" id="CAL0135420">
        <property type="gene designation" value="CAGL0L11902g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11902g"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FKF9"/>
    <dbReference type="OMA" id="TIAHFST"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046041">
        <property type="term" value="P:ITP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="97"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="148"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0135420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="251" mass="28074" checksum="8EFAC214882359C9" modified="2004-07-19" version="1">MSLRLARPLRLLLLGAPGSGKGTQTSKLLKVLPELKSVSSGDILRHELKSGTELGVLAAKYIAQGKLIPDKVITQVLIAHLSKEKWLNPQSSWLLDGFPRTERQAFSLDSTLGENNAKLNLVVELDVPEEVILERIDNRYIHVGSGRVYNLQYNPPKVAGKDDVTGEPLVKRSDDNVQVFKKRMKEYKKTLGPIKEHYAKQGILATISGDTSDIIFPKLCALINQHFGAKEQQLHHEAFESKKEQKIQPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKH8</accession>
    <name>Q6FKH8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0L11462g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62240.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKH8"/>
    <dbReference type="FunCoup" id="Q6FKH8">
        <property type="interactions" value="1199"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKH8"/>
    <dbReference type="KEGG" id="cgr:2890966"/>
    <dbReference type="CGD" id="CAL0135686">
        <property type="gene designation" value="CAGL0L11462g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11462g"/>
    <dbReference type="eggNOG" id="KOG1694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066767_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FKH8"/>
    <dbReference type="OMA" id="KWYNADD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0135686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62240.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="176" mass="19918" checksum="D50D28B2996FD1B0" modified="2008-09-23" version="2">MTALKPQKWYPAEDVAVPKKTRKTARPQKLRASLVPGTVLILLAGRFRGKRVVYLKHMEDNTLLVSGPFKVNGVPLRRVNARYVIATSTKVDLSGVDVAKFNVEYFAREKLNKKEKKEAQMFPENSSKQVKAERVEDQKNVDKALLANIKKTPLLKQYLAASFSLKNGDKPHLLNF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKL3</accession>
    <name>ROT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein ROT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ROT1</name>
        <name type="ordered locus">CAGL0L10670g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ROT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449231.1">
        <property type="nucleotide sequence ID" value="XM_449231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKL3"/>
    <dbReference type="FunCoup" id="Q6FKL3">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKL3"/>
    <dbReference type="GlyCosmos" id="Q6FKL3">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0L10670g-T">
        <property type="protein sequence ID" value="CAGL0L10670g-T-p1"/>
        <property type="gene ID" value="CAGL0L10670g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891042"/>
    <dbReference type="KEGG" id="cgr:2891042"/>
    <dbReference type="CGD" id="CAL0135740">
        <property type="gene designation" value="CAGL0L10670g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L10670g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10670g"/>
    <dbReference type="eggNOG" id="ENOG502QQTG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071622_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKL3"/>
    <dbReference type="OMA" id="YKPPQML"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017290">
        <property type="entry name" value="ROT1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000333408" description="Protein ROT1">
        <location>
            <begin position="22"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="263" mass="29129" checksum="FC45FCB3792BEDF5" modified="2004-07-19" version="1" precursor="true">MVRSLLFALLSVAGLVAGDAADLVGTWSSKSNQVFTGPGFYDPIDELLIEPALPGISYSFTEDGWFEEASYQVSGNPKNPACPKASLIYQHGKFELLDNGTLILHPIEVDGRQLFSDPCSDNGISTYTRYNQTEVFKSFETFIDPYHGVYTLQLYQFNGAPLPPLYLAYRPPMMLPTETLNPTDGSTGSHPTGSSESESQESDDTSKRSLLKKRSLREHVKRSLENRYKTNAVKKSDSIFNAAFVWYTSFFLVGAGSLIFISS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKM8</accession>
    <name>SLD7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial morphogenesis protein SLD7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SLD7</name>
        <name type="ordered locus">CAGL0L10340g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the proper initiation of DNA replication. Required for mitochondrial morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLD7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449216.1">
        <property type="nucleotide sequence ID" value="XM_449216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKM8"/>
    <dbReference type="SMR" id="Q6FKM8"/>
    <dbReference type="FunCoup" id="Q6FKM8">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKM8"/>
    <dbReference type="EnsemblFungi" id="CAGL0L10340g-T">
        <property type="protein sequence ID" value="CAGL0L10340g-T-p1"/>
        <property type="gene ID" value="CAGL0L10340g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891067"/>
    <dbReference type="KEGG" id="cgr:2891067"/>
    <dbReference type="CGD" id="CAL0135148">
        <property type="gene designation" value="CAGL0L10340g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10340g"/>
    <dbReference type="eggNOG" id="ENOG502RZIJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072105_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKM8"/>
    <dbReference type="OMA" id="EFTHRDE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016808">
        <property type="entry name" value="Sld7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041260">
        <property type="entry name" value="Sld7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041564">
        <property type="entry name" value="Sld7_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18596">
        <property type="entry name" value="Sld7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18636">
        <property type="entry name" value="Sld7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022788">
        <property type="entry name" value="UCP022788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000411025" description="Mitochondrial morphogenesis protein SLD7">
        <location>
            <begin position="1"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="279" mass="31874" checksum="956F6327E86612BB" modified="2004-07-19" version="1">MSLVANLKLSIGSKNNEFVLRDVQLWETSDTSILDAGQLKRVQSYKGRFVAYVDIKKLPLWIKNQQSRELQCFTRSSTTLRYFSTKLGVKQRGIVFECIPLTEKADNQGCCSYYIFYRNENVVKVVQVDLSIKANIDLQIKQIKSTLSNPQQADVKKLDSTVSATIDSRLNSDITKIVSENIERHEHRTSKVLKSMLSNDKKIQVRDTLSKLILAGLRLRGLSSTKSETQKLFRITLSASEFAHRKDLIQLQRGHTKAIPFEEMQETVETLLNLFTRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKQ8</accession>
    <name>Q6FKQ8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyl hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0L09493g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKQ8"/>
    <dbReference type="FunCoup" id="Q6FKQ8">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKQ8"/>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891134"/>
    <dbReference type="CGD" id="CAL0135406">
        <property type="gene designation" value="CAGL0L09493g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09493g"/>
    <dbReference type="eggNOG" id="ENOG502QPU8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009024_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FKQ8"/>
    <dbReference type="OMA" id="AACRYFA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000174">
        <property type="entry name" value="YIR007W-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="4">
        <location>
            <begin position="62"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="5">
        <location>
            <begin position="629"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0135406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="83438" checksum="1A6AEE39E19670C6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL61</accession>
    <name>Q6FL61_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0L05940g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449033.1">
        <property type="nucleotide sequence ID" value="XM_449033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL61"/>
    <dbReference type="FunCoup" id="Q6FL61">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL61"/>
    <dbReference type="KEGG" id="cgr:2890813"/>
    <dbReference type="CGD" id="CAL0135066">
        <property type="gene designation" value="CAGL0L05940g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05940g"/>
    <dbReference type="HOGENOM" id="CLU_564068_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL61"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0135066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="482" mass="55513" checksum="9D3ED026F10D8EE9" modified="2004-07-19" version="1">MAVELPGYFYDTEKRRYFKITNSINASIELSGNKYSRDVLNNVKVNLLGQQSKKAYTDPYKIQDEYLKDRSIRYMVDNNVLSKGQIFKQSESSASIVSTNNITFPYSDKIIAAQDVNYIEDGLHRTKTLYITSAGQILETRIDSPPNTAILLFRPEDTEESTIDLANFEVSQYYLGLVLVHMVGSHGKNILFWSVQNRNETINFRSKVIENKYMTYVTLLDPNHIFYLLGNKLHFVSSENFSFDNKLTLYPKERSYWRLKGQITCVKFNPIDNETYRIYAGSRNGILTSFIFSVKYGVMPKSVQTWDRPGNLITIVSMLSTNIDGIIFVSGLTNKKDHSQTIIALNTKSLLPNLTHMLTLKSHFRNVTQSTEIFLLNQHENILLYGCKRGVRVEPDFEIFKLDSNSPINDKSHHILPNLKFSSLLDKKYFTSPFELIQIVGEIGEQNVKKNIDDRIFIKRLLIKVFAKVSHHNQTCMIIVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLE1</accession>
    <name>Q6FLE1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0L04114g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLE1"/>
    <dbReference type="FunCoup" id="Q6FLE1">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLE1"/>
    <dbReference type="KEGG" id="cgr:2890767"/>
    <dbReference type="CGD" id="CAL0135654">
        <property type="gene designation" value="CAGL0L04114g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04114g"/>
    <dbReference type="eggNOG" id="KOG2236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025072_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FLE1"/>
    <dbReference type="OMA" id="WKNDDEP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:box H/ACA snoRNP assembly"/>
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        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
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        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
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        <property type="entry name" value="Gar1"/>
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    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
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            <end position="186"/>
        </location>
    </feature>
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            <end position="386"/>
        </location>
    </feature>
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        <location>
            <begin position="514"/>
            <end position="580"/>
        </location>
    </feature>
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            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0135654"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG61923.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="580" mass="65263" checksum="B349F7AFC84DD19D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLT1</accession>
    <name>Q6FLT1_CANGA</name>
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        <recommendedName>
            <fullName evidence="6">Protein GVP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">GVP36</name>
        <name evidence="3 4" type="ordered locus">CAGL0L00891g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_448813.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="cgr:2890935"/>
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        <property type="gene designation" value="GVP36"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L00891g"/>
    <dbReference type="eggNOG" id="ENOG502QQ2V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059017_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLT1"/>
    <dbReference type="OMA" id="NIMFATR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
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    </dbReference>
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        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
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        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BAR/IMD domain-like"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="341"/>
        </location>
    </feature>
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        </location>
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            <end position="341"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0135780"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG61783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="38079" checksum="5A16B0356127E6E5" modified="2004-07-19" version="1">MSNFNSFANSLRENLQSFSNTVSQKTHELSTNIPTLAQSTQRMVQEKLGQVTDISQLPQEYLELENKVDTIKIVYEHFLQVTAVYENESYDYPKYVSESVNEFSKNMAAKVQELSKATSATEAQNILVAPGPVKEPKTLNYAMSKVALNASEYLNHSFDDPMDAKLSKVLLNYSDVQTKVAQARLQQDTQIQTKFNKVIRENLAESIARANKARKDVQSKRLQYDVARTNLQNAKPEKEAGLRVQMETLEDQFAQATEDATVVMQEVIASANFLPSLKELATAQLEYYEQSAKLMKEFISSVDSSSSDAPASKTSKTSQTSTTTDAGISLEDDDDEPLPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLU7</accession>
    <name>Q6FLU7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L00539g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLU7"/>
    <dbReference type="FunCoup" id="Q6FLU7">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891107"/>
    <dbReference type="CGD" id="CAL0135658">
        <property type="gene designation" value="CAGL0L00539g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L00539g"/>
    <dbReference type="eggNOG" id="ENOG502S4DB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1496199_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLU7"/>
    <dbReference type="OMA" id="PGYNDCP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="223" mass="24725" checksum="21147E499F8410B4" modified="2004-07-19" version="1">MTNTMPVRSYQNCSENDVVGYNDCPESLFVMPAVKAAKKTRPRRIPVSVNTDTQSSKINEGVSSESASKDDDVLNLPKSRLAKASAVPPPPIGRRSTSSSVSSLMCDSPTPLQSRSSSMSTLDNVSLLDENELMKKVANILNAESKLSNKEYEYYKGKIDSNLEESLKNDKVRIFLSRFFSELESSKNKEFAQKILLRGMTSDTTINSWCPAFHKIFDNASCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLX7</accession>
    <name>Q6FLX7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTP-binding protein YPT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0K12672g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLX7"/>
    <dbReference type="FunCoup" id="Q6FLX7">
        <property type="interactions" value="1230"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLX7"/>
    <dbReference type="KEGG" id="cgr:2890422"/>
    <dbReference type="CGD" id="CAL0134615">
        <property type="gene designation" value="CAGL0K12672g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12672g"/>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_1_1"/>
    <dbReference type="InParanoid" id="Q6FLX7"/>
    <dbReference type="OMA" id="TQMAKDF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990261">
        <property type="term" value="P:pre-mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900101">
        <property type="term" value="P:regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000359">
        <property type="entry name" value="Small GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23275" checksum="9FCCB5911333F0BA" modified="2004-07-19" version="1">MNSEYDYLFKLLLIGNSGVGKSCLLLRFSDDTYTNDYISTIGVDFKIKTVELDGKTVKLQIWDTAGQERFRTITSSYYRGSHGIIIVYDVTDQESFNGVKMWLQEIDRYATSTVLKLLVGNKCDLADKRVVEYDVAKEFAEANKMPFLETSALDSTNVEEAFLTMARQIKESMTQQNMNESQQKKNDKGNVNLKGQSLTQSGSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLX9</accession>
    <name>Q6FLX9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="10">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0K12628g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="10"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FLX9">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLX9"/>
    <dbReference type="KEGG" id="cgr:2890420"/>
    <dbReference type="CGD" id="CAL0133811">
        <property type="gene designation" value="CAGL0K12628g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12628g"/>
    <dbReference type="eggNOG" id="KOG1038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003364_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FLX9"/>
    <dbReference type="OMA" id="KWFEVDM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1320.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="11">
        <location>
            <begin position="394"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0133811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1326" mass="150799" checksum="AC99662214D34720" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLY7</accession>
    <name>Q6FLY7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0K12452g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLY7"/>
    <dbReference type="FunCoup" id="Q6FLY7">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLY7"/>
    <dbReference type="KEGG" id="cgr:2889986"/>
    <dbReference type="CGD" id="CAL0134405">
        <property type="gene designation" value="CAGL0K12452g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12452g"/>
    <dbReference type="eggNOG" id="KOG2595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039465_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FLY7"/>
    <dbReference type="OMA" id="YLRDFMM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="62"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0134405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="501" mass="58080" checksum="AAAD04F864C1D11E" modified="2004-07-19" version="1">MHTGYRDQLGLSHYDILSGSEILGSHLENHVREKGKIELLDNTISKKDIDVLRALGYTEFGYARHNLRRKAWHIILRSQYVAEHNDKIQSTAKTVTHKDEKQIELDVNRSFNNLKNGPQRAYLRKVLQKLLIRFFRSNSELSYYQGFHDVLSIFILVFLNYDDDNTGEHVIYKVENIESLFYCVEAFSLLYLRDFLMPTLDFSIDQLKVIQNYILNKDEELYEKMQLDVIHPLYAISSVLTVFAHELKPTVDDQSHEIFEVFDMIISSQSMFLPLKIYATLFLQFKSDIITTYEVNIENFENEADLIHCVIQQVIQKNLYSHEIHNESFINAIKKVRLAKASEYTLTNVSDMVNVYSPLVTTARGESQLFTSEEINEIVGKQLIYHNKQQQLKIQAKERLLKPKSKHINSMLSIIGGHGSISPLIKASIAVAIVAILLRMNKNKRIIAGISTGKEFIGEIKHLHSSIFYSLKNSYWKDPLKIVLHTYKKLQNQLSSSDFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM25</accession>
    <name>Q6FM25_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0K11572g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM25"/>
    <dbReference type="FunCoup" id="Q6FM25">
        <property type="interactions" value="1231"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM25"/>
    <dbReference type="KEGG" id="cgr:2890522"/>
    <dbReference type="CGD" id="CAL0134503">
        <property type="gene designation" value="CAGL0K11572g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11572g"/>
    <dbReference type="eggNOG" id="KOG3158">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078883_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM25"/>
    <dbReference type="OMA" id="EEGPYWP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032212">
        <property type="term" value="P:positive regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000055">
        <property type="entry name" value="HSP90 associated co-chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="4"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0134503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="218" mass="23871" checksum="EECB233A19927487" modified="2004-07-19" version="1">MSKVLTPEVAWAQRSSESDAEKNYLLITVSIPDCESPEVKIEAGSLDLEAQSRGHVGDEHKHTYKLHIDFYKDIVPEKSLHKIANGQHYFLKLFKKDLELEYWPRLTKEKIKYSNIKTDFDKWVDEDEQETAADTGMPGDMDFSQLMGGMGGAGMGGMGDMGGMPGMGGMGGPGGPSMEQLQSMLSQQGGLGGLGGEDLGDFGGEDEDEEEIEEIKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM39</accession>
    <name>Q6FM39_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0K11275g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM39"/>
    <dbReference type="FunCoup" id="Q6FM39">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM39"/>
    <dbReference type="KEGG" id="cgr:2890064"/>
    <dbReference type="CGD" id="CAL0133925">
        <property type="gene designation" value="CAGL0K11275g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11275g"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_172_4_1"/>
    <dbReference type="InParanoid" id="Q6FM39"/>
    <dbReference type="OMA" id="ICCNACR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF541">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="10"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="466"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0133925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="525" mass="60582" checksum="7AE6916061AC1B91" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMB2</accession>
    <name>MDM32_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial distribution and morphology protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MDM32</name>
        <name type="ordered locus">CAGL0K09482g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448632.1">
        <property type="nucleotide sequence ID" value="XM_448632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMB2"/>
    <dbReference type="FunCoup" id="Q6FMB2">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0K09482g-T">
        <property type="protein sequence ID" value="CAGL0K09482g-T-p1"/>
        <property type="gene ID" value="CAGL0K09482g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890234"/>
    <dbReference type="KEGG" id="cgr:2890234"/>
    <dbReference type="CGD" id="CAL0133869">
        <property type="gene designation" value="CAGL0K09482g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09482g"/>
    <dbReference type="eggNOG" id="ENOG502QQU5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016236_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FMB2"/>
    <dbReference type="OMA" id="FAKEMVG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000333678" description="Mitochondrial distribution and morphology protein 32">
        <location>
            <begin position="15"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="2">
        <location>
            <begin position="15"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="156"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="629"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="649" mass="74050" checksum="CD8D54C0CDB5DE2E" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FME2</accession>
    <name>Q6FME2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AP5</name>
        <name evidence="7 8" type="ordered locus">CAGL0K08756g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FME2"/>
    <dbReference type="FunCoup" id="Q6FME2">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FME2"/>
    <dbReference type="KEGG" id="cgr:2890283"/>
    <dbReference type="CGD" id="CAL0134489">
        <property type="gene designation" value="AP5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08756g"/>
    <dbReference type="eggNOG" id="ENOG502QUE5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_963771_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FME2"/>
    <dbReference type="OMA" id="SHERAKP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="349" mass="39145" checksum="9ECBBD84BC921144" modified="2004-07-19" version="1">MLTALGSMGENYPVLRPKDSVAEKMAMSKIHISKKWKLPPLRPKGSHERAKPSPSMDAGAKVSPAGDSPTGEDSKHMSGPNRKRLQNREAQRAYRERSRNKLQTLEDNVETLQGMVKMWQSKYKQLASEFDQYKQSSNEKIVELEKTISESKEDSKCYICMKNVDLDGLKENARNEDIKPFFQDEFLSNAIKNFQPMEAVSLKRKQEKNSSSPSITPRSSTTSFAAVLNDVDKGNCGFCNDNTACVCRDITSTLSAKPPQRRSDILLDTMSKSGLSTESIKSNYAVSALRSTHCSENPSKCTKCSDIDTSCLKSVPADNKRSSIYMEELPMEFEVNLNDLFPSPKRQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMG4</accession>
    <name>Q6FMG4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial RNA-splicing protein MRS4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0K08250g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMG4"/>
    <dbReference type="FunCoup" id="Q6FMG4">
        <property type="interactions" value="630"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMG4"/>
    <dbReference type="KEGG" id="cgr:2890348"/>
    <dbReference type="CGD" id="CAL0134009">
        <property type="gene designation" value="CAGL0K08250g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08250g"/>
    <dbReference type="eggNOG" id="KOG0760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FMG4"/>
    <dbReference type="OMA" id="MYNSQHQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000104">
        <property type="entry name" value="Iron transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000054">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="110"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="199"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0134009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32532" checksum="20C8C37171C6B930" modified="2004-07-19" version="1">MDEEIDYEALPPCAPLHHQLLAGAFAGIMEHSVLFPVDAIKTRIQSSSSGAATQGLIKQISKITTAEGSLALWKGVQSVILGAGPAHAVYFATYEFSKSKLIDPQDMHTHQPIKTAISGMAATTVADALMNPFDVIKQRMQLNTRESVWHVTKNIYHKEGFAAFYYSYPTTLVMNIPFAAFNFAIYESATKFMNPSNEYNPFIHCISGGLSGATCAAITTPLDCIKTVLQVRGSETVSNEIMKQANTFQRAASAIYKIHGWKGFLRGLKPRVIANMPATAISWTSYECAKHFLVNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMJ6</accession>
    <name>Q6FMJ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphomutase PMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PMU1</name>
        <name evidence="2 3" type="ordered locus">CAGL0K07524g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448548.1">
        <property type="nucleotide sequence ID" value="XM_448548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMJ6"/>
    <dbReference type="FunCoup" id="Q6FMJ6">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="GeneID" id="2890380"/>
    <dbReference type="KEGG" id="cgr:2890380"/>
    <dbReference type="CGD" id="CAL0133981">
        <property type="gene designation" value="PMU1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07524g"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMJ6"/>
    <dbReference type="OMA" id="THSGFTR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000054">
        <property type="entry name" value="Putative phosphomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273456" description="Phosphomutase PMU1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="37608" checksum="92129BBDF1FC888E" modified="2004-07-19" version="1">MILHRLLLLLNLDWNREVEMTVQDLDVRALPGYFKGYSARDTPETRHNATELDFLAFDDQFTTWKQLYQAIPKDTDTHSYKLLVLARHGEGYHNAAEARYGEKAWNEYWSKLEGDQYGSWLDAELTPLGKKQALEAGQTYLTNLTDGLQLLPHKFFVSPMRRCLDTYIREWEPVFSTHRPSNATVNVKVIEYLRETLGVHTCDERVSHSQALSEYQDHRYNNSDVTVHFDYPGNYSEKDQLWYPDHRETKAEMDRRTRIGLREMFSSVNTTDKVISLTCHSGVIASVLRNIKHPAIDHLQTGKLVYAVVELSKAPTDDQPMLVVS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-08" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMR7</accession>
    <name>SDHF3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Succinate dehydrogenase assembly factor 3, mitochondrial</fullName>
            <shortName evidence="1">SDH assembly factor 3</shortName>
            <shortName evidence="1">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAGL0K05775g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMR7"/>
    <dbReference type="SMR" id="Q6FMR7"/>
    <dbReference type="FunCoup" id="Q6FMR7">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMR7"/>
    <dbReference type="EnsemblFungi" id="CAGL0K05775g-T">
        <property type="protein sequence ID" value="CAGL0K05775g-T-p1"/>
        <property type="gene ID" value="CAGL0K05775g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890470"/>
    <dbReference type="CGD" id="CAL0134925">
        <property type="gene designation" value="CAGL0K05775g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K05775g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05775g"/>
    <dbReference type="eggNOG" id="KOG4100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102310_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FMR7"/>
    <dbReference type="OMA" id="WQQTNEN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006111">
        <property type="term" value="P:regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000042743" description="Succinate dehydrogenase assembly factor 3, mitochondrial">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q04401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q8SZ16"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="137" mass="15899" checksum="D7ACA2927CA62036" modified="2004-07-19" version="1" precursor="true">MIGRRQLVTVFRRYASQNGVIGQDHTLLPPLMLYRRILRAHKLLPPMQKEMGDKYVKSEFELHRTIDNPLHIVGFLASWQDYLHQITNGKWKEGSLSPAVLEKMSPEQVGQLYELMKETEKVTKGDNPEEDKGKNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMV0</accession>
    <name>Q6FMV0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0K05005g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMV0"/>
    <dbReference type="FunCoup" id="Q6FMV0">
        <property type="interactions" value="996"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMV0"/>
    <dbReference type="CAZy" id="GT22">
        <property type="family name" value="Glycosyltransferase Family 22"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890500"/>
    <dbReference type="CGD" id="CAL0134155">
        <property type="gene designation" value="CAGL0K05005g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05005g"/>
    <dbReference type="eggNOG" id="KOG2515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018152_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FMV0"/>
    <dbReference type="OMA" id="PRDMHAK"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052926">
        <property type="term" value="F:dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052918">
        <property type="term" value="F:dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0134155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="558" mass="64475" checksum="A49B2130088A6A30" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNE3</accession>
    <name>Q6FNE3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0K00627g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448251.1">
        <property type="nucleotide sequence ID" value="XM_448251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNE3"/>
    <dbReference type="FunCoup" id="Q6FNE3">
        <property type="interactions" value="298"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890229"/>
    <dbReference type="CGD" id="CAL0134053">
        <property type="gene designation" value="CAGL0K00627g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00627g"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019048_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FNE3"/>
    <dbReference type="OMA" id="YDKLTLM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="371"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="15"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="267"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0134053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="410" mass="46880" checksum="2693E43D8B6660A2" modified="2004-07-19" version="1">MLTKLPHSVQTNIHIITLCLCWYFISSLASQVTKQILTICPLPLFLGEFQFLFTALLAAISCALAFNYRWIYDLFPEGTFPRYYVTIHEHENERDQERIYAITRPSKHIITTVLPLSFFQFVGKYFGHTATALVPVSTVASVKTLSPVFIVIFQKMLKMPTVNLNVRILTSLAALIFGVWLIVNEDNKQKLASKKKTQLIDTESGRSSNYGIVCAIISMFIFVMQNIYGKKVFTYKRNHEKTMIPKKKSIYNLGDNPSELPIYSESKTLSPKTTKYDKLTLMIYISLVGFSLSFFWFMTIEFSTVWRYLCGYTTQSDGQPLIISTIPWTLFLLNGVFHFMQAMITFHLLGEVSTLTYSIANLMKRIAIISVSWLFAGIHVTLLQIVGLSLNAIGLFLYERYSSTQKHANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNI0</accession>
    <name>Q6FNI0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0J11528g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61165.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_448214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNI0"/>
    <dbReference type="FunCoup" id="Q6FNI0">
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    </dbReference>
    <dbReference type="KEGG" id="cgr:2889530"/>
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        <property type="gene designation" value="CAGL0J11528g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11528g"/>
    <dbReference type="eggNOG" id="ENOG502S3IE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039198_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNI0"/>
    <dbReference type="OMA" id="WSENAEQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0133142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="557" mass="64073" checksum="E168918985F1B341" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNQ6</accession>
    <name>Q6FNQ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0J09856g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNQ6"/>
    <dbReference type="FunCoup" id="Q6FNQ6">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNQ6"/>
    <dbReference type="KEGG" id="cgr:2889423"/>
    <dbReference type="CGD" id="CAL0133744">
        <property type="gene designation" value="CAGL0J09856g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09856g"/>
    <dbReference type="eggNOG" id="ENOG502RZ6E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130029_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FNQ6"/>
    <dbReference type="OMA" id="RRSQFPK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="24"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="177" mass="20189" checksum="9BE525E8739DD158" modified="2004-07-19" version="1">MLRNLIWKRLASTGGHPNATKISLPRRPLKKIRPGKARPAIYHQFNVKVELSDGSVISRRSQFPKDEFRLISDQRNNPLWNPSRDDLVVIDVNSGGSKDKFKQKYSSIFSVDDAVDTKAEEKEVKSSKETKTEDKKEVKKDVEEDAFGVDDYLSLLDDSSKQIKTGKLAQKKKKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNR3</accession>
    <name>Q6FNR3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Activator of C kinase protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0J09702g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNR3"/>
    <dbReference type="FunCoup" id="Q6FNR3">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNR3"/>
    <dbReference type="KEGG" id="cgr:2889719"/>
    <dbReference type="CGD" id="CAL0133386">
        <property type="gene designation" value="CAGL0J09702g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09702g"/>
    <dbReference type="eggNOG" id="KOG1550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026113_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FNR3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="76614" checksum="C8F7DEA5A41866B8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNY5</accession>
    <name>Q6FNY5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SEC14 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0J08074g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Microsome</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAG61010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FNY5">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNY5"/>
    <dbReference type="KEGG" id="cgr:2889916"/>
    <dbReference type="CGD" id="CAL0133026">
        <property type="gene designation" value="CAGL0J08074g"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="Q6FNY5"/>
    <dbReference type="OMA" id="RPLFYMK"/>
    <dbReference type="Proteomes" id="UP000002428">
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    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901352">
        <property type="term" value="P:negative regulation of phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006658">
        <property type="term" value="P:phosphatidylserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001247">
        <property type="term" value="P:positive regulation of phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000013">
        <property type="entry name" value="Phosphatidylinositol transfer protein PDR16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN PDR17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0492">Microsome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="6">
        <location>
            <begin position="135"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00083195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0133026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="347" mass="40341" checksum="49A8EEECAFFC3BDE" modified="2004-07-19" version="1">MGIFSRKKKEATPVNRGDLIPCETMIEAPPKGSPPPKKPADLDAEQTKKLAQMLEHFNKPDLVLPVSSTDDTGKTRPISSWEKFFLTRDCFLRYLRAQKWDVPKAIKMLTETLVWRREVGITHGEEDEHPLKPEDIAVENETGKEILLGFDYDRRPLFYMKNGRQNTESSFRQVQQMLFMMECATTLTPQGVEKMCVLVDFKHYKEPGIITDKAPPISIAKMCLHIMQNHYPERLGKCILINIPWFIWAFLKMMYNFLDPATKEKVIFDEPFTNHIDPSQLEATYDGRLDFKYNHAVYWPDMNAKIEAIRNKQYERFQKFGAVMGLSEWDLKGDHDELVYPVDSIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP13</accession>
    <name>Q6FP13_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J07458g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP13"/>
    <dbReference type="FunCoup" id="Q6FP13">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP13"/>
    <dbReference type="KEGG" id="cgr:2889594"/>
    <dbReference type="CGD" id="CAL0133380">
        <property type="gene designation" value="CAGL0J07458g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07458g"/>
    <dbReference type="eggNOG" id="KOG3409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067135_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP13"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000312">
        <property type="entry name" value="Exosome complex component CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048626">
        <property type="entry name" value="CSL4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019495">
        <property type="entry name" value="EXOSC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21551">
        <property type="entry name" value="CSL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10447">
        <property type="entry name" value="EXOSC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exosome complex component CSL4 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Exosome complex component CSL4 C-terminal" evidence="4">
        <location>
            <begin position="122"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0133380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="285" mass="31247" checksum="D30F1CC11F874DE7" modified="2004-07-19" version="1">MSEHLPIDQTVFPGDLICPEIGSEKQEDKLIIYKYTPGRGCSLQKYKYNQHSLDAIVSTVVGVVETQEIEPETTETKENNTVTTEGDTDRTVKYVEVRVVPIPKDLEVEYKSNKDNNFANNLPKEGDVVLARVTRISAQKVNVEILAVENEPIPLDSGVGSNGAGKVAPGGGSGASTFSVSQASSDLGETFRGMIRSQDIRATERDRVKVIESYKPGDIIRAQILSLGDGNNYYLTTARNDLGVVFARSDNGAGGLMYAVDWQTMVSPFTGVQERRKCAKPFEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPE0</accession>
    <name>Q6FPE0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate aminotransferase</fullName>
            <ecNumber evidence="7">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0J04554g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447904.1">
        <property type="nucleotide sequence ID" value="XM_447904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPE0"/>
    <dbReference type="STRING" id="284593.Q6FPE0"/>
    <dbReference type="KEGG" id="cgr:2889642"/>
    <dbReference type="CGD" id="CAL0133200">
        <property type="gene designation" value="CAGL0J04554g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04554g"/>
    <dbReference type="eggNOG" id="KOG1412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032440_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FPE0"/>
    <dbReference type="OMA" id="MGFEMFC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000064">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="8">
        <location>
            <begin position="35"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0133200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="419" mass="47024" checksum="DCD4496CD09255D7" modified="2004-07-19" version="1">MVKISATVYNDVEPIKTDILFATKQRYLKDTRGFKVDLGVGAYRADNGKPWILPSVRKAERLVQEEDDYDHEYLNICGLDSLTNSAAKVILGEDCPALRESRVISVQSLSGAGALHVAAKFIKKYTPEKKIYLSNPTWPIHQSIFENVDLETDSYPYWDATNKSLDFEGFIKAIDHAPRGSIFVLHACAHNPTGLDPTQEQWHQIIESIQKGDHIPLFDSAYQGFASGDLERDAYAIRYTINQLRDCAPIFVAQSFAKNVGMYGERVGCLHLVLPAQKEDIVPIKDAITSQLSRIIRSEISTPPAYGAKVVSKIFTTPELKEQWYQDLVTMSSRIISVRTRLRDLLAEYNTPGNWDHIVQQCGMFSFTGLTPEMTKRLETEHAVYMVPTGRASVAGLNTGNVQHVAKAINEVVNHFMKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-07-05" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPE8</accession>
    <name>RFT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RFT1</name>
        <name type="ordered locus">CAGL0J04378g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RFT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447896.1">
        <property type="nucleotide sequence ID" value="XM_447896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPE8"/>
    <dbReference type="SMR" id="Q6FPE8"/>
    <dbReference type="FunCoup" id="Q6FPE8">
        <property type="interactions" value="735"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPE8"/>
    <dbReference type="EnsemblFungi" id="CAGL0J04378g-T">
        <property type="protein sequence ID" value="CAGL0J04378g-T-p1"/>
        <property type="gene ID" value="CAGL0J04378g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889634"/>
    <dbReference type="KEGG" id="cgr:2889634"/>
    <dbReference type="CGD" id="CAL0132928">
        <property type="gene designation" value="CAGL0J04378g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04378g"/>
    <dbReference type="eggNOG" id="KOG2864">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023360_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FPE8"/>
    <dbReference type="OMA" id="WPGKLFG"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034202">
        <property type="term" value="F:glycolipid floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000212416" description="Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1">
        <location>
            <begin position="1"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="551" mass="63121" checksum="88CCCC70DFD3B94C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPJ8</accession>
    <name>Q6FPJ8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0J03256g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPJ8"/>
    <dbReference type="FunCoup" id="Q6FPJ8">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPJ8"/>
    <dbReference type="KEGG" id="cgr:2889733"/>
    <dbReference type="CGD" id="CAL0133228">
        <property type="gene designation" value="CAGL0J03256g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03256g"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007989_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FPJ8"/>
    <dbReference type="OMA" id="KDWPDLG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071852">
        <property type="term" value="P:fungal-type cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903138">
        <property type="term" value="P:negative regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071507">
        <property type="term" value="P:pheromone response MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF547">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="77"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="521"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="733"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="549"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0133228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="884" mass="100714" checksum="FF624B0A305C1561" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPV6</accession>
    <name>RPN1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPN1</name>
        <name type="ordered locus">CAGL0J00605g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447738.1">
        <property type="nucleotide sequence ID" value="XM_447738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPV6"/>
    <dbReference type="SMR" id="Q6FPV6"/>
    <dbReference type="FunCoup" id="Q6FPV6">
        <property type="interactions" value="1672"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPV6"/>
    <dbReference type="EnsemblFungi" id="CAGL0J00605g-T">
        <property type="protein sequence ID" value="CAGL0J00605g-T-p1"/>
        <property type="gene ID" value="CAGL0J00605g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889882"/>
    <dbReference type="KEGG" id="cgr:2889882"/>
    <dbReference type="CGD" id="CAL0133686">
        <property type="gene designation" value="CAGL0J00605g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J00605g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J00605g"/>
    <dbReference type="eggNOG" id="KOG2005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008705_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FPV6"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905754">
        <property type="term" value="C:ascospore-type prospore nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000173812" description="26S proteasome regulatory subunit RPN1">
        <location>
            <begin position="1"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 1">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 2">
        <location>
            <begin position="448"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 3">
        <location>
            <begin position="485"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 4">
        <location>
            <begin position="520"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 5">
        <location>
            <begin position="563"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 6">
        <location>
            <begin position="768"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 7">
        <location>
            <begin position="800"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="688"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="983" mass="109675" checksum="5AA3CD4678085013" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="155" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPV9</accession>
    <name>Q6FPV9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 11">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SLT2</name>
        <name evidence="14 15" type="ordered locus">CAGL0J00539g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with RLM1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 11"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447735.1">
        <property type="nucleotide sequence ID" value="XM_447735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPV9"/>
    <dbReference type="FunCoup" id="Q6FPV9">
        <property type="interactions" value="502"/>
    </dbReference>
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        <property type="gene designation" value="SLT2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J00539g"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome J"/>
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        <property type="term" value="C:cellular bud neck"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="362"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00065684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0133196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="488" mass="56342" checksum="DFD43715B97C111B" modified="2004-07-19" version="1">MDVERQTFKVFNQDFTIDKRFELIKEIGHGAYGIVCSARFTEASEETTVAIKKVTNIFSKTLLCKRSLRELKLLRHFRGHKNITCLYDMDIVFYPDGSINGLYLYEELMECDMHQIIKSGQALTDAHYQSFTYQILCGLKYIHSADVLHRDLKPGNLLVNADCQLKICDFGLARGYSENPEENNQFLTEYVATRWYRAPEIMLSYQGYTKAIDIWSTGCILAEFLGGKPLFKGKDYVDQLNRILQVLGTPPDETLRRVGSKNVQDYIHQLGYIQKIPFSELFPNANEDALDLLEGMLAFDPQKRITVDKALEHPYLTIWHDPADEPECNEKFEFSFESVNEMEDLKRMVVDEVQSFREFVRQPLMDDKSQEDEQQQGSPENYQQTSPTNISPQRLHNNGSHDLLQEPEFLTQTPNQNSTIPDQLQESFVGIHSDNLPEHDTDFPPRPQENILASPMGLPSASDRNSMNNDSFLDLERELEFGLDRRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPW8</accession>
    <name>Q6FPW8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0J00341g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPW8"/>
    <dbReference type="STRING" id="284593.Q6FPW8"/>
    <dbReference type="MEROPS" id="M01.007"/>
    <dbReference type="KEGG" id="cgr:2889911"/>
    <dbReference type="CGD" id="CAL0132892">
        <property type="gene designation" value="CAGL0J00341g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J00341g"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FPW8"/>
    <dbReference type="OMA" id="AWDFIQV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
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    </dbReference>
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        <location>
            <begin position="12"/>
            <end position="194"/>
        </location>
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        <location>
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            <end position="445"/>
        </location>
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            <begin position="517"/>
            <end position="831"/>
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        <location>
            <position position="301"/>
        </location>
    </feature>
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        <location>
            <position position="300"/>
        </location>
        <ligand>
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        <location>
            <position position="304"/>
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            <position position="323"/>
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        <ligand>
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        <location>
            <position position="386"/>
        </location>
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        </source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0132892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG60673.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="857" mass="97286" checksum="C99534A121DCFA07" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ59</accession>
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        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
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                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
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                <person name="Scarpelli C."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        <property type="project" value="TreeGrafter"/>
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        </location>
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    <feature type="domain" description="RRM" evidence="3">
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        </location>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0132406"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG60572.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000002428"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="5">Cleavage/polyadenylation specificity factor A subunit N-terminal domain-containing protein</fullName>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
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    <dbReference type="STRING" id="284593.Q6FQ80"/>
    <dbReference type="KEGG" id="cgr:2888918"/>
    <dbReference type="CGD" id="CAL0130304">
        <property type="gene designation" value="CAGL0I08415g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08415g"/>
    <dbReference type="eggNOG" id="ENOG502R4DC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_260916_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ80"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1308" mass="148061" checksum="10F1F43E118C996A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQB3</accession>
    <name>Q6FQB3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0I07645g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQB3"/>
    <dbReference type="FunCoup" id="Q6FQB3">
        <property type="interactions" value="828"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQB3"/>
    <dbReference type="KEGG" id="cgr:2889001"/>
    <dbReference type="CGD" id="CAL0132314">
        <property type="gene designation" value="CAGL0I07645g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07645g"/>
    <dbReference type="eggNOG" id="KOG0991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FQB3"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000015">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000107">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="42"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0132314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="322" mass="36105" checksum="F99944B4DB5BB520" modified="2004-07-19" version="1">MSKATLTLELPWVEKYRPHLLKDIVGNEETVERLQQIAADGNMPHMIISGLPGIGKTTSIHCLAHEMLGESYSQAVLELNASDDRGIDVVRNQIKHFAQKKCHLPPGKHKIIILDEADSMTAGAQQALRRTMELYSNSTRFAFACNQSNKIIEPLQSRCAILRYSKLSDEQVLKRLLEIIKAEDVQYTNDGLEAIIFTAEGDMRQAINNLQSTVAGHGLVNGENVFKIVDSPHPLIVKKMLLAETLDESIDCLRQELWAKGYSAVDIVTTCFRVTKNLFQLKESVRLEMIKEIGTTHMRILEGVSTYLQLASMLAKIHKLKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQJ2</accession>
    <name>ATG3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATG3</name>
        <name type="ordered locus">CAGL0I05808g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Interacts with ATG8 through an intermediate thioester bond through the C-terminal Gly of ATG8. Also interacts with the 40 amino acid C-terminal region of the E1-like ATG7 enzyme. Also interacts with the ATG12-ATG5 conjugate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal region is involved in phosphatidylethanolamine-binding and is required for ATG8-PE conjugation.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The flexible region (FR) is required for ATG7-binding.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The handle region (HR) contains the ATG8 interaction motif (AIM) and mediates binding to ATG8. It is crucial for the cytoplasm-to-vacuole targeting pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447502.1">
        <property type="nucleotide sequence ID" value="XM_447502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQJ2"/>
    <dbReference type="SMR" id="Q6FQJ2"/>
    <dbReference type="FunCoup" id="Q6FQJ2">
        <property type="interactions" value="1134"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQJ2"/>
    <dbReference type="EnsemblFungi" id="CAGL0I05808g-T">
        <property type="protein sequence ID" value="CAGL0I05808g-T-p1"/>
        <property type="gene ID" value="CAGL0I05808g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889347"/>
    <dbReference type="KEGG" id="cgr:2889347"/>
    <dbReference type="CGD" id="CAL0132232">
        <property type="gene designation" value="CAGL0I05808g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I05808g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05808g"/>
    <dbReference type="eggNOG" id="KOG2981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027518_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FQJ2"/>
    <dbReference type="OMA" id="HCPTWSW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000213577" description="Autophagy-related protein 3">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Handle region" evidence="1">
        <location>
            <begin position="226"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="1">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="309" mass="35528" checksum="8424C2251E73DF49" modified="2004-07-19" version="1">MIRSALSNWREYLTPVSHKSTFLTTGQITPEEFVQAGDYLCHMFPTWKWNDMADDNKYRDFLPKDKQFLVIRKVPCSERAQAVVTMDEIENGTSTDAFSAADDEDNDDDSIEIIPVSKSSSGADNDVNDIDELMEEMELEEDDDIVANKTNEMLRYYDLFITYSTSYRVPKMYIVGFNGNGTPLTPKEMFEDITPDYRKKTATIEKLPFYKRNVPSVSIHPCKHANVMKVLLDKISVVKERQREEEMQKNAEVGAPKSAGSDDGDNENWEDLQQDIDDSLRVDLYLVVFLKFITSVTPTIQHDYTMEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQP3</accession>
    <name>Q6FQP3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 23" type="ordered locus">CAGL0I04642g</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQP3"/>
    <dbReference type="FunCoup" id="Q6FQP3">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQP3"/>
    <dbReference type="KEGG" id="cgr:2889035"/>
    <dbReference type="CGD" id="CAL0132310">
        <property type="gene designation" value="CAGL0I04642g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04642g"/>
    <dbReference type="eggNOG" id="KOG1179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_46_3_1"/>
    <dbReference type="InParanoid" id="Q6FQP3"/>
    <dbReference type="OMA" id="VWRQFLD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000038">
        <property type="term" value="P:very long-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000020">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="21">
        <location>
            <begin position="83"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="CGD" id="CAL0132310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAG60388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="672" mass="77847" checksum="EE59772CC4534C5E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQQ7</accession>
    <name>Q6FQQ7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0I04334g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQQ7"/>
    <dbReference type="FunCoup" id="Q6FQQ7">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQQ7"/>
    <dbReference type="KEGG" id="cgr:2889046"/>
    <dbReference type="CGD" id="CAL0132756">
        <property type="gene designation" value="CAGL0I04334g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04334g"/>
    <dbReference type="eggNOG" id="KOG2822">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019266_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FQQ7"/>
    <dbReference type="OMA" id="GRWEYPY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="9">
        <location>
            <begin position="128"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0132756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="425" mass="48911" checksum="ECD0ADC602D3FE2D" modified="2004-07-19" version="1">MEHQPVITLNDVNGNSTDVLVSHNVKSRIRARSRALSNPNDYQELNVLNDPGNHPDEHYKAMSPIRFKVRSWLRKYVDNQSETLYYWQSRWRCKFLDLYFSYTSLMGSHTFYVLFLPLPVYFGYFEFTRDMVYILGYSIYLSGFLKDYCCLPRPRSPPLHRITLSAYTAKEYGAPSSHTANATGVSLLFLIALMQSTRYSGFSKAFLFAMVMFYYLTLVLGRIYCGMHGVLDLVSGTAVGVFCCIVRVATSWLLSEWDYGKELWFPVLSVVWGLTILFKHIQPIDECPCFEDSVAFMGVVSGLEVSDWVIRHFFDDRSLIYAFTNEYTYGQLASRLGFGVLLVVLWKYILSKPLVYSVFLKTICRMPDDRQEKQHLKIELTANSGEECIRYVGVAHIDIIGRFIIYAGIPISVMLVSPLILKWSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQS3</accession>
    <name>Q6FQS3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Vacuolar proton pump subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">VMA1</name>
        <name evidence="28 29" type="ordered locus">CAGL0I03960g</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Vacuole membrane</location>
            <topology evidence="19">Peripheral membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447421.1">
        <property type="nucleotide sequence ID" value="XM_447421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQS3"/>
    <dbReference type="FunCoup" id="Q6FQS3">
        <property type="interactions" value="1211"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQS3"/>
    <dbReference type="MEROPS" id="N09.001"/>
    <dbReference type="GeneID" id="2889093"/>
    <dbReference type="KEGG" id="cgr:2889093"/>
    <dbReference type="CGD" id="CAL0132692">
        <property type="gene designation" value="VMA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03960g"/>
    <dbReference type="eggNOG" id="KOG1352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQS3"/>
    <dbReference type="OMA" id="CFAKGTE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006314">
        <property type="term" value="P:intron homing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000003">
        <property type="entry name" value="Vacuolar ATP synthase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001296">
        <property type="entry name" value="Vacuolar membrane ATPase subunit a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007868">
        <property type="entry name" value="Hom_end_hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007869">
        <property type="entry name" value="Homing_endonuc_PI-Sce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030934">
        <property type="entry name" value="Intein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05204">
        <property type="entry name" value="Hom_end"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05203">
        <property type="entry name" value="Hom_end_hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50818">
        <property type="entry name" value="INTEIN_C_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0404">Intron homing</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="23">
        <location>
            <begin position="29"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="26">
        <location>
            <begin position="132"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Hom-end-associated Hint" evidence="24">
        <location>
            <begin position="285"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Homing endonuclease PI-Sce" evidence="25">
        <location>
            <begin position="573"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="27">
        <location>
            <begin position="886"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF05203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF05204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="CGD" id="CAL0132692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="CAG60358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1033" mass="113437" checksum="0CB28A4C0643D841" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQX7</accession>
    <name>Q6FQX7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0I02684g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQX7"/>
    <dbReference type="FunCoup" id="Q6FQX7">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889021"/>
    <dbReference type="CGD" id="CAL0129885">
        <property type="gene designation" value="CAGL0I02684g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02684g"/>
    <dbReference type="eggNOG" id="KOG2338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034867_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQX7"/>
    <dbReference type="OMA" id="PEISNWA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="95"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0129885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="493" mass="57478" checksum="8CF8186ECA0EEA1A" modified="2004-07-19" version="1">MTQEEVVHVAENPAAVNAVKEVKKSKGKKKGKGKPSPEEIARIRAEREAMREAKRQEMLERGVDPDCPPELQFIRRNMLKLHEEEPVEGLKIKIMSYNCLAQALIRRKLFPDSGEALKWYRRSRVLLNEFKHYDPDVLCLQEIDYIQYQSFWKEEFQKLGYSSQFHRKPSKNHGVCIIWKHEKFEMSDRMLIDFDSEKSGDIEPRTTTNNAALILALKFTQKVKMMGKKLLDDKSGILVGTTHLFWHPFGTYERTRQCYVVLNKMKEFMHRVNVLQNNNDGDMSHWYPFFCGDFNSQPFDSPYLSMTCKPIKYDSRAKTVIECSTSFKFSKKRESGEDAEDEEGGNIEKFGKDQPQTPVPEKFVANDEQTKLVSQMEELHNSLDMRAVSLYSVAYHKVHPENSGLDNERGEPEISNWAHTWRGLLDYMFMIRNWEFDDRTEIDTLEDFENSNNIKIRGLLRMPPGSEMSTHGQPHVGEYPSDHLCLLSEVELR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQY7</accession>
    <name>ATG7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>ATG12-activating enzyme E1 ATG7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATG7</name>
        <name type="ordered locus">CAGL0I02420g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The GxGxxG motif is important for the function, possibly through binding with ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447357.1">
        <property type="nucleotide sequence ID" value="XM_447357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQY7"/>
    <dbReference type="SMR" id="Q6FQY7"/>
    <dbReference type="FunCoup" id="Q6FQY7">
        <property type="interactions" value="795"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQY7"/>
    <dbReference type="EnsemblFungi" id="CAGL0I02420g-T">
        <property type="protein sequence ID" value="CAGL0I02420g-T-p1"/>
        <property type="gene ID" value="CAGL0I02420g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889381"/>
    <dbReference type="KEGG" id="cgr:2889381"/>
    <dbReference type="CGD" id="CAL0132204">
        <property type="gene designation" value="CAGL0I02420g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02420g"/>
    <dbReference type="eggNOG" id="KOG2337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012998_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FQY7"/>
    <dbReference type="OMA" id="RQIWDAI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097632">
        <property type="term" value="C:extrinsic component of phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000212812" description="Ubiquitin-like modifier-activating enzyme ATG7">
        <location>
            <begin position="1"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG motif">
        <location>
            <begin position="327"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="1">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="623" mass="70746" checksum="721C110E203E1F41" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR95</accession>
    <name>Q6FR95_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0H10384g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR95"/>
    <dbReference type="FunCoup" id="Q6FR95">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR95"/>
    <dbReference type="KEGG" id="cgr:2888833"/>
    <dbReference type="CGD" id="CAL0131576">
        <property type="gene designation" value="CAGL0H10384g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10384g"/>
    <dbReference type="eggNOG" id="KOG1612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046570_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FR95"/>
    <dbReference type="OMA" id="INKRWHW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0131576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="264" mass="29352" checksum="EC7FB448D45F6B05" modified="2004-07-19" version="1">MVLSVTEKAFLADSLKADPVIRPDGREAYQNRPIELFVNFLPSSNGSSRIIASDGSECIVSVKSKVVDHTLEDELIEVDVDIVGYRDDSLLVESTSSFLKKALRLGETVERKSLQLTTKYSFKLYIDILVISCNSNPTSLISFGMYTALKSTYLPKLISSYDDLQVEELPTFHDYDLVKLEIDPPVVFLLAIVGDNIILDPAANECEVANNGLLLTWSNGKIVSPVRTIALNDTHLEGFDQNIIKLAYEMVTQYAPEIVRALDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRD7</accession>
    <name>Q6FRD7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H09394g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447207.1">
        <property type="nucleotide sequence ID" value="XM_447207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRD7"/>
    <dbReference type="KEGG" id="cgr:2888537"/>
    <dbReference type="CGD" id="CAL0130200">
        <property type="gene designation" value="CAGL0H09394g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09394g"/>
    <dbReference type="HOGENOM" id="CLU_924373_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRD7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="301" mass="34792" checksum="360F57314196FD67" modified="2004-07-19" version="1">MSSESRIVGEFSEYLKEVEQRVRREIEAELAEKYERRLKELEAAAEGHTRADSHVRADGNGVEVTEVQERGIEGGFSDKRRPSDEKDRHLKRIRGIKEWPEVVMRLHKRPPSNATMLMWEELECLLIYLHTGVNITEQIKDNVCRVEAVRMAQLVCFTEITSLEAKIQLVQEGYGKIRSKHVDSMLFSLVARFCPHIVLDANEELVGTYTKAITETDLLTQDRDLFKDDYLANYTADLLSVQELLKQEQVQYNDWTVFLDACIPEKISDGVLRNSNNNLLPWDCAVLEIFKRWGSSRMEAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRH2</accession>
    <name>ATG11_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATG11</name>
        <name type="ordered locus">CAGL0H08558g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2010" name="Cell. Microbiol." volume="12" first="199" last="216">
            <title>Autophagy supports Candida glabrata survival during phagocytosis.</title>
            <authorList>
                <person name="Roetzer A."/>
                <person name="Gratz N."/>
                <person name="Kovarik P."/>
                <person name="Schuller C."/>
            </authorList>
            <dbReference type="PubMed" id="19811500"/>
            <dbReference type="DOI" id="10.1111/j.1462-5822.2009.01391.x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity). Contributes through its regulation of pexophagy to survival during engulfment by host phagocytic cells during infection. Through its function in autophagy, acts as an important virulence factor that supports the viability of C.glabrata in the phagosomal compartment of infected innate immune cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATG11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447172.1">
        <property type="nucleotide sequence ID" value="XM_447172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRH2"/>
    <dbReference type="SMR" id="Q6FRH2"/>
    <dbReference type="FunCoup" id="Q6FRH2">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRH2"/>
    <dbReference type="EnsemblFungi" id="CAGL0H08558g-T">
        <property type="protein sequence ID" value="CAGL0H08558g-T-p1"/>
        <property type="gene ID" value="CAGL0H08558g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888485"/>
    <dbReference type="KEGG" id="cgr:2888485"/>
    <dbReference type="CGD" id="CAL0130611">
        <property type="gene designation" value="ATG11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08558g"/>
    <dbReference type="eggNOG" id="ENOG502QVZE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272501_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRH2"/>
    <dbReference type="OMA" id="EIDVHYF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071957">
        <property type="term" value="C:old mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000124545" description="Autophagy-related protein 11">
        <location>
            <begin position="1"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="264"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="651"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="19811500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1110" mass="127649" checksum="D5BF8AE34FBABD89" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRN8</accession>
    <name>Q6FRN8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acyl-coenzyme A diphosphatase YFT2</fullName>
            <ecNumber evidence="8">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">FIT family protein YFT2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">YFT2</name>
        <name evidence="8" type="synonym">FIT2A</name>
        <name evidence="10 11" type="ordered locus">CAGL0H07117g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization). Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FIT family. Yeast FIT2A/YFT2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447106.1">
        <property type="nucleotide sequence ID" value="XM_447106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRN8"/>
    <dbReference type="FunCoup" id="Q6FRN8">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRN8"/>
    <dbReference type="GeneID" id="2888513"/>
    <dbReference type="KEGG" id="cgr:2888513"/>
    <dbReference type="CGD" id="CAL0131542">
        <property type="gene designation" value="CAGL0H07117g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07117g"/>
    <dbReference type="eggNOG" id="KOG3750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086757_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRN8"/>
    <dbReference type="OMA" id="LILWCEL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03232">
        <property type="entry name" value="YFT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046398">
        <property type="entry name" value="YFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23129:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE FITM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0131542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="260" mass="29267" checksum="7883759DB95D890B" modified="2004-07-19" version="1">MFVPTRKQVSLAYPVILILGCFLSVLLSEEAKINQRANYYLLNSKNVFNQILAYKGNWVWLFLFMGVAAVQYNLRTKSQSLLPTDTRALVVSNKTKLQIIKEYFCKYFLKLFILDVIFLVIDGVFIMTGGSCTVPNRSISAELCKSLGGKWIGGFDISGHFCFLVNISMILWMELIAIAEHVCGYDTVISLSSLQKHVITVAVVVLVAWMGMLLVTATYYHTIAEKLIGCVFGYICPFVMYGLIPNSHDLNKLFYATMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRQ5</accession>
    <name>Q6FRQ5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H06743g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRQ5"/>
    <dbReference type="FunCoup" id="Q6FRQ5">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRQ5"/>
    <dbReference type="KEGG" id="cgr:2888556"/>
    <dbReference type="CGD" id="CAL0131880">
        <property type="gene designation" value="CAGL0H06743g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06743g"/>
    <dbReference type="eggNOG" id="ENOG502RZQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092488_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FRQ5"/>
    <dbReference type="OMA" id="EFLIHEW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0131880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20127" checksum="8C93915C443B7971" modified="2004-07-19" version="1">MMSMLPSRMLRQRTALAAVRGLRTGSRVMVELKDKERPMTVNAELPDPMAGRRKRIAAFAAFSLATGSALAVIFNYEKTESAIVSNTMYYMRRSGQTIDALGENIEFAGVIPWVWGELNPVAGKINITFSVKGKKGVTGIVKLVADRENRREEFRIHEWSLTVPDKKIDLLAENPHSSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRT0</accession>
    <name>Q6FRT0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21" type="ordered locus">CAGL0H06193g</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRT0"/>
    <dbReference type="FunCoup" id="Q6FRT0">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRT0"/>
    <dbReference type="KEGG" id="cgr:2888691"/>
    <dbReference type="CGD" id="CAL0132032">
        <property type="gene designation" value="CAGL0H06193g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06193g"/>
    <dbReference type="eggNOG" id="KOG0389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_16_2_1"/>
    <dbReference type="InParanoid" id="Q6FRT0"/>
    <dbReference type="OMA" id="IQDKWAA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033120">
        <property type="term" value="P:positive regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17998">
        <property type="entry name" value="DEXHc_SMARCAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002378">
        <property type="entry name" value="ATP-dependent helicase FUN30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="17">
        <location>
            <begin position="74"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="584"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="957"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="443"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="466"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0132032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG59997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1126" mass="127494" checksum="F99FD7B7ECB45ACA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRZ2</accession>
    <name>Q6FRZ2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0H04763g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRZ2"/>
    <dbReference type="STRING" id="284593.Q6FRZ2"/>
    <dbReference type="KEGG" id="cgr:2888791"/>
    <dbReference type="CGD" id="CAL0131532">
        <property type="gene designation" value="CAGL0H04763g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04763g"/>
    <dbReference type="eggNOG" id="KOG0106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054994_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FRZ2"/>
    <dbReference type="OMA" id="AQFTKHF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031370">
        <property type="term" value="F:eukaryotic initiation factor 4G binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061752">
        <property type="term" value="F:telomeric repeat-containing RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000805">
        <property type="term" value="P:negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12340">
        <property type="entry name" value="RBD_RRM1_NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034166">
        <property type="entry name" value="Npl3_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="105"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="180"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="327"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0131532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="383" mass="42374" checksum="481B1A0FA3C641C0" modified="2004-07-19" version="1">MDKPVEDQEVPQQEQEDVPPPPPAEAPQEQEQQQEQEQPQEQEQEQQQEQEQPAEEMNVEHQDAPVHHEPMPYESQFPEPPQPYYNQPPQGVPTFHQQEGELSNTRLFVRPFPLDVQESELNEIFGPFGAMKEVKILNGFAFVEFEEAESASKAIEEVNGKTFANQPLEVMFSKMPVKRFRITLKNLPEGCSWQELKDLARENNLETTFSSVNSRDFDGTGALEFPTEEIMNDALEKLNNIEFRGSVISVEIDDNPPPIRRSNRGGFRGRGGFRGGFRGGFNGPRGGFRGGYGGPRGGYGGRGGFNGPRGGFRGGYNSGGFRGGYGAPRGGFGQGPRGGYGAPRGGYGGSRGGYGAPRGDYGAPRDSYRTRDAPPRERSPTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS78</accession>
    <name>Q6FS78_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0H02805g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS78"/>
    <dbReference type="FunCoup" id="Q6FS78">
        <property type="interactions" value="1394"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS78"/>
    <dbReference type="KEGG" id="cgr:2888562"/>
    <dbReference type="CGD" id="CAL0129916">
        <property type="gene designation" value="CAGL0H02805g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02805g"/>
    <dbReference type="eggNOG" id="KOG0964">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FS78"/>
    <dbReference type="OMA" id="GQKTVCA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051177">
        <property type="term" value="P:meiotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="10">
        <location>
            <begin position="535"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="173"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="261"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="408"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="698"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="863"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="980"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0129916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1219" mass="139799" checksum="12BF317748B9306E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSD7</accession>
    <name>MHR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mitochondrial homologous recombination protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MHR1</name>
        <name type="ordered locus">CAGL0H01353g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446857.1">
        <property type="nucleotide sequence ID" value="XM_446857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSD7"/>
    <dbReference type="SMR" id="Q6FSD7"/>
    <dbReference type="FunCoup" id="Q6FSD7">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSD7"/>
    <dbReference type="EnsemblFungi" id="CAGL0H01353g-T">
        <property type="protein sequence ID" value="CAGL0H01353g-T-p1"/>
        <property type="gene ID" value="CAGL0H01353g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888662"/>
    <dbReference type="KEGG" id="cgr:2888662"/>
    <dbReference type="CGD" id="CAL0130090">
        <property type="gene designation" value="CAGL0H01353g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H01353g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01353g"/>
    <dbReference type="eggNOG" id="ENOG502QSKX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092898_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSD7"/>
    <dbReference type="OMA" id="YRPTYTQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090297">
        <property type="term" value="P:positive regulation of mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000255963" description="Large ribosomal subunit protein mL67">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="201" mass="24113" checksum="5B2A5DE682321675" modified="2004-07-19" version="1">MSLMNKAVSRFRTAGWLEKAGYSPWLYLYRNLERGQVMYSQLPEYGERNIKTQFKRHQWENKTPSLRRDIWRVMCVVQMPNHQDSVQVYQNLCRLRYMRDVLYREEAQKHRKLNDKGQVWYSGQYRPTYTQEAVADLKESIDKSGSAGPVTLVWEDMWRMGERSVWEELDLEIKHRALPKLGNVIRDEHAMLKQLQLESLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSK2</accession>
    <name>Q6FSK2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0G09933g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSK2"/>
    <dbReference type="FunCoup" id="Q6FSK2">
        <property type="interactions" value="796"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSK2"/>
    <dbReference type="KEGG" id="cgr:2888140"/>
    <dbReference type="CGD" id="CAL0130753">
        <property type="gene designation" value="CAGL0G09933g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09933g"/>
    <dbReference type="eggNOG" id="KOG3482">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_12_3_1"/>
    <dbReference type="InParanoid" id="Q6FSK2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000070">
        <property type="entry name" value="Small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="8"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0130753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="86" mass="9787" checksum="B0CA796102479752" modified="2004-07-19" version="1">MSDFTPINPKPFLKDLVDKPIVVTLKFNKTQYRGVLVSTDNYFNLQLRDAQEYVAGELKGTLGELFIRCNNVLYIGEDLSKEDTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSV1</accession>
    <name>Q6FSV1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptide hydrolase</fullName>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0G07623g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSV1"/>
    <dbReference type="FunCoup" id="Q6FSV1">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSV1"/>
    <dbReference type="MEROPS" id="M28.001"/>
    <dbReference type="KEGG" id="cgr:2888341"/>
    <dbReference type="CGD" id="CAL0130677">
        <property type="gene designation" value="CAGL0G07623g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07623g"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024336_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FSV1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02130">
        <property type="entry name" value="PA_ScAPY_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000093">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF17">
        <property type="entry name" value="AMINOPEPTIDASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005144033" description="Peptide hydrolase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="7">
        <location>
            <begin position="206"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="8">
        <location>
            <begin position="324"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0130677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="563" mass="62203" checksum="4D466F950B7CE02C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSV6</accession>
    <name>Q6FSV6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein ATP12, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0G07513g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSV6"/>
    <dbReference type="FunCoup" id="Q6FSV6">
        <property type="interactions" value="730"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSV6"/>
    <dbReference type="KEGG" id="cgr:2888428"/>
    <dbReference type="CGD" id="CAL0130318">
        <property type="gene designation" value="CAGL0G07513g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07513g"/>
    <dbReference type="eggNOG" id="KOG3015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047893_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FSV6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0130318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36628" checksum="50300C40EE7EA1A5" modified="2004-07-19" version="1">MLKVYRRLSYWRLHIGRTRFYHASSRASPLGVDSSIENNLKTETNKLSKTGQKFWDQVGLDFGGDKITVQLDSKPLRTPLGNNLAIDHDRKVLGLMLKKEWSNLQEVASKKFSLPLTSLVSRCIDLETTSNADCDPEAVAKIGGDTTVIKNQLLRYMDTDTLLVFSPAKEFEGALREEQDKLYLPIIKKIEEFLGQYSSSDKQLTLQILDADVHGLRGNVQSQEVKDAAMNYMDSLSPWDLAVFEKTVLTTKSFICGILLMESMTKKSTHKELVKSLDEIIRLATLETIFQVERWGEVEDTHDVDKRDIHRKISSAAIVAFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSX7</accession>
    <name>Q6FSX7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0G07040g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSX7"/>
    <dbReference type="FunCoup" id="Q6FSX7">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSX7"/>
    <dbReference type="KEGG" id="cgr:2888090"/>
    <dbReference type="CGD" id="CAL0137533">
        <property type="gene designation" value="CAGL0G07040g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07040g"/>
    <dbReference type="eggNOG" id="KOG2603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052855_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FSX7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF3">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273559" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6" evidence="6">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0137533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="37306" checksum="74058823D947FAE3" modified="2004-07-19" version="1">MRMHAIALLISLIVGVFSITTEELDRLKDEDGIIAVTDANYAQISKGLEDYYNVLFITMRSTNDEGVALCKICLDFEDNYRNVVRLFQSQFPDKKVYFFSSDVQETRQIVRDMDLKNVPHAVVYPPKKDGEVYSWAKTPFYKYELVDKEVSNPLHFGSFLGKIMEVEITIPQEFDVQEFLTYFVICTAIFVVLKRVVLPIVGNKGLLFSIVLAFGILLPSIAGFKFTQINGIPFIARDGKGNIMFFSGGTGWQFGIEVVTVSAMYVAMSIVVTLLVYWKKLCKGNDNANVLGSLFCACLMFFLVHTTLAAIRLNSPSIHLNSSAYMSLLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSY8</accession>
    <name>Q6FSY8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LSO1/LSO2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G06798g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446656.1">
        <property type="nucleotide sequence ID" value="XM_446656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSY8"/>
    <dbReference type="FunCoup" id="Q6FSY8">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSY8"/>
    <dbReference type="KEGG" id="cgr:2888236"/>
    <dbReference type="CGD" id="CAL0137739">
        <property type="gene designation" value="CAGL0G06798g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06798g"/>
    <dbReference type="HOGENOM" id="CLU_186256_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSY8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="90" mass="10336" checksum="AE7E329DC85660D4" modified="2004-07-19" version="1">MGKRFSESAAKVAQGRARKRQQEWEKNRAQKEQLEAMEAKKWEEGAREGTSKKALLEEKRQQKLAAKKERDALLKAEEEAIGRGGKLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT94</accession>
    <name>Q6FT94_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0G04389g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT94"/>
    <dbReference type="FunCoup" id="Q6FT94">
        <property type="interactions" value="558"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT94"/>
    <dbReference type="KEGG" id="cgr:2888022"/>
    <dbReference type="CGD" id="CAL0130765">
        <property type="gene designation" value="CAGL0G04389g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04389g"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_594549_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT94"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="77"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0130765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="462" mass="51357" checksum="88B3C2D67F9E12B6" modified="2004-07-19" version="1">MAEHSEDMSGKSPRREAQDYKKGDVVDSEHKQSISTESSTASKDTSVVQSKVEQKVDSKKEKVVAQGDTAGIVSEFGNSAPVCKNCMTSTTPLWRRDEQGSVLCNACGLFLKLHGKPRPISLKTDVIKSRNRKNVQTSPTGAPAELVHDRYKHSFTNFIPTSYEAYKEKKGHMLDKRRHPPSDLRHSITEHGRPYVGESAEADLIRKHKKAKIKSERAVSESSIDSYNSQSKDSAQIKSGENTPLSPQSHSPSGTPLPRLSAVLGDFGSDSRTTAASNSNIGSMHAKSSEDDKNGNIASLEQSMVEKRKTSIPQVVNSNQSYGGLPTALRGAPIRDSRSTGSNIKEKMSQPQPLDTSHLSHIPPNPHLLMKGKVPSSENLPIRRGSMIDTQKQRNSVDIIDPSNADDEHKIPVSVQLHNEEEVIRLRTRINELELVTDLYKRHIYELDERCKKLEKELRRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTC1</accession>
    <name>Q6FTC1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0G03663g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTC1"/>
    <dbReference type="FunCoup" id="Q6FTC1">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTC1"/>
    <dbReference type="KEGG" id="cgr:2888371"/>
    <dbReference type="CGD" id="CAL0130300">
        <property type="gene designation" value="CAGL0G03663g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03663g"/>
    <dbReference type="eggNOG" id="KOG0439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072622_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTC1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061163">
        <property type="term" value="P:endoplasmic reticulum polarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042308">
        <property type="term" value="P:negative regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032377">
        <property type="term" value="P:regulation of intracellular lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060304">
        <property type="term" value="P:regulation of phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="3"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0130300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="258" mass="28355" checksum="499BDD3C8727D170" modified="2004-07-19" version="1">MSLVDISPDVLEYKSPLTRQSTAYVTVKNNSDQAIAFKVKTTAPKFYCVRPNASVVAPGEIVDVQVIFLGLPEAPAPDYKCRDKFLVITLPSPYDLGSKSVSEAWADLEAEFKQQAISKKIKVKYLIDTEVEKNPQSVPETEDARETIQPAHQPAPIAETKPSEVTENKMPMTKEVPVAAPVTAAPITADIEEKNAMPKTETHENVDELKEEPPVTTTEKEEAKVQSSVTKKSGNEGSTNTMLIVICLAVLILGWLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTE2</accession>
    <name>Q6FTE2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G03201g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446502.1">
        <property type="nucleotide sequence ID" value="XM_446502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTE2"/>
    <dbReference type="STRING" id="284593.Q6FTE2"/>
    <dbReference type="KEGG" id="cgr:2888217"/>
    <dbReference type="CGD" id="CAL0130699">
        <property type="gene designation" value="CAGL0G03201g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03201g"/>
    <dbReference type="eggNOG" id="ENOG502RYSQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085409_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTE2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="41"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0130699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="215" mass="24251" checksum="7E44DAC545582E87" modified="2004-07-19" version="1">MFPFVRLGVVRCLPLQHLVTKRCLSYGGKHVVTQQKFKESMAKVANQAMVLTAASPVGTSHELFHGLTISSMTSLALKPHPMIQFNLQLPSATSDTLHQNRYFAIHLLNPTNESIDIIRNFSKGALQGINRTMPFKDLEMNEHYMIHKIGNKTNYDLPILKEAQLAIICKKKNVFRVGDHEIWVGVVEDTIVMNDDTNGGVLYCNRNFHKLGSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTI3</accession>
    <name>Q6FTI3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">54S ribosomal protein L20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0G02277g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTI3"/>
    <dbReference type="FunCoup" id="Q6FTI3">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTI3"/>
    <dbReference type="KEGG" id="cgr:2888009"/>
    <dbReference type="CGD" id="CAL0129433">
        <property type="gene designation" value="CAGL0G02277g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02277g"/>
    <dbReference type="eggNOG" id="ENOG502S0A4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089054_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTI3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0129433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="24069" checksum="562BD03FFB83F905" modified="2004-07-19" version="1">MMMKRGFHSGSAMMKGVDKFVVRNSTKPMKELRGSPTIYNSTNSSSNSKGYLKAQRLLEPGLYLNRAQSSPMGSTNIETIPLGFIPKDDPRREYIRHLKYQEKDKQLSKLAPPVLVSKSTVEGKKYHLQPEDISEIKRLRLEDPVKNNRKALAEKFGVSPLFISIVSEPPKSHKEEMKSRLETIKSKWHAKRAIARSDRQKRQELWYRA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTL0</accession>
    <name>YTH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>mRNA 3'-end-processing protein YTH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">YTH1</name>
        <name type="ordered locus">CAGL0G01694g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446434.1">
        <property type="nucleotide sequence ID" value="XM_446434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTL0"/>
    <dbReference type="SMR" id="Q6FTL0"/>
    <dbReference type="FunCoup" id="Q6FTL0">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTL0"/>
    <dbReference type="EnsemblFungi" id="CAGL0G01694g-T">
        <property type="protein sequence ID" value="CAGL0G01694g-T-p1"/>
        <property type="gene ID" value="CAGL0G01694g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888311"/>
    <dbReference type="KEGG" id="cgr:2888311"/>
    <dbReference type="CGD" id="CAL0137715">
        <property type="gene designation" value="CAGL0G01694g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_G01694g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01694g"/>
    <dbReference type="eggNOG" id="KOG1040">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024513_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FTL0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000238535" description="mRNA 3'-end-processing protein YTH1">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type 1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type 2" evidence="2">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type 3" evidence="2">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type 4" evidence="2">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type 5" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="209" mass="24557" checksum="1D9BA23F405E503C" modified="2004-07-19" version="1">MGSVVHPDTEKYPFKFEPFLRQEYSFALDPDRPVCEDFNYKIGPSSCPNGVFCPKKHVLGIFQNKIVCKHWLRGLCKKNDNCEYLHEYNLRKMPECVFYAKNGFCTQSPECQYLHIDPLSKVPPCEDYEMGFCPKGSACEKRHIKKVLCQRYINGFCPLGRRECDMEHPFFYIPDLSSPLRIKKDEEINTRKRDEENERRLNAIINGEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU05</accession>
    <name>NSA1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Ribosome biogenesis protein NSA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NSA1</name>
        <name type="ordered locus">CAGL0F07403g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446289.1">
        <property type="nucleotide sequence ID" value="XM_446289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU05"/>
    <dbReference type="SMR" id="Q6FU05"/>
    <dbReference type="FunCoup" id="Q6FU05">
        <property type="interactions" value="714"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU05"/>
    <dbReference type="EnsemblFungi" id="CAGL0F07403g-T">
        <property type="protein sequence ID" value="CAGL0F07403g-T-p1"/>
        <property type="gene ID" value="CAGL0F07403g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887812"/>
    <dbReference type="KEGG" id="cgr:2887812"/>
    <dbReference type="CGD" id="CAL0131194">
        <property type="gene designation" value="CAGL0F07403g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07403g"/>
    <dbReference type="eggNOG" id="KOG3881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033769_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FU05"/>
    <dbReference type="OMA" id="IWEAKNV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22858">
        <property type="entry name" value="Nsa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000320397" description="Ribosome biogenesis protein NSA1">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="436" mass="49415" checksum="1C084AC67C76F6B8" modified="2004-07-19" version="1">MRVLASCVDNGSLKEAVFGFGTDTSVQTAPQPQLIETHLCEGLDAHVEQIHKIDDGKWLLARHNGTVQYVESELVDHSEIEGMKVSHFDVVGSITGLLDVSRLDHLNAQSKRRTKLKDGFVSLAPVSKKDCYLACTKSGLVHILALNFKDKLLTKLQTFEVKAPLEFAQVYDVEKTKKTVFACGGEENLVKLFELSESCDKISMIWESKNVKNDRLDMRVPVWPVALKFLQPVPTSSAGYDKNKLNFQFLVVTGWSHFGIYNTQHGKRPMKYLDLLPEREPLRQLELLDPSHNTKAITQLGNLKCKETESLEFITTDKKTQVLKYNGQGQLIGKYGKGDITGLATYIGIHDQKYLLEGGLDRYLRVFDIESRAQKAKIYLGTNINRILVLDEELEALQEIEMAKNNKRKQTASDEEDDAEELWSKLETKKEKKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU11</accession>
    <name>Q6FU11_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA replication regulator SLD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0F07271g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU11"/>
    <dbReference type="FunCoup" id="Q6FU11">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU11"/>
    <dbReference type="KEGG" id="cgr:2887622"/>
    <dbReference type="CGD" id="CAL0131236">
        <property type="gene designation" value="CAGL0F07271g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07271g"/>
    <dbReference type="eggNOG" id="ENOG502RE09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_409479_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU11"/>
    <dbReference type="OMA" id="KNMCKAA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013948">
        <property type="entry name" value="DNA_replication_reg_Sld3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042511">
        <property type="entry name" value="Sld3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041393">
        <property type="entry name" value="Sld3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28067:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18523">
        <property type="entry name" value="Sld3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08639">
        <property type="entry name" value="Sld3_STD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld3 N-terminal" evidence="3">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="176"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication regulator Sld3 C-terminal" evidence="2">
        <location>
            <begin position="281"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0131236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="733" mass="83939" checksum="2077EE994B53A0CD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU12</accession>
    <name>Q6FU12_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0F07249g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446282.1">
        <property type="nucleotide sequence ID" value="XM_446282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU12"/>
    <dbReference type="FunCoup" id="Q6FU12">
        <property type="interactions" value="1307"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU12"/>
    <dbReference type="KEGG" id="cgr:2887818"/>
    <dbReference type="CGD" id="CAL0130920">
        <property type="gene designation" value="CAGL0F07249g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07249g"/>
    <dbReference type="eggNOG" id="KOG2549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021711_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FU12"/>
    <dbReference type="OMA" id="YFVQFIA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="9">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0130920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="536" mass="58945" checksum="5A6E2A7DA434E5E7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU61</accession>
    <name>CCS1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CCS1</name>
        <name type="ordered locus">CAGL0F06017g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Copper chaperone for superoxide dismutase 1 (SOD1). Binds copper ions and delivers them specifically to SOD1.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
        <text evidence="1">Binds 2 copper ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446233.1">
        <property type="nucleotide sequence ID" value="XM_446233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU61"/>
    <dbReference type="SMR" id="Q6FU61"/>
    <dbReference type="FunCoup" id="Q6FU61">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU61"/>
    <dbReference type="EnsemblFungi" id="CAGL0F06017g-T">
        <property type="protein sequence ID" value="CAGL0F06017g-T-p1"/>
        <property type="gene ID" value="CAGL0F06017g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887621"/>
    <dbReference type="KEGG" id="cgr:2887621"/>
    <dbReference type="CGD" id="CAL0130932">
        <property type="gene designation" value="LYS7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06017g"/>
    <dbReference type="eggNOG" id="KOG4656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056632_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU61"/>
    <dbReference type="OMA" id="KNVWEER"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902693">
        <property type="term" value="C:superoxide dismutase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016532">
        <property type="term" value="F:superoxide dismutase copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000038">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0186">Copper</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000239061" description="Superoxide dismutase 1 copper chaperone">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="28"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with C-58 in apo-SOD1)" evidence="2">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P40202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="239" mass="26124" checksum="E3FBFF3A740C7713" modified="2004-07-19" version="1">MTANADFYEATYAVPMHCTDCTDDIKKCLNGITGIKDLQFDISQQMMSVNSCVAPSVIINALRDCGRDAIIRGAGKPNSSAVAILETFEDVDLKKDTAVRGLARIVQVSDQKTLFDVTVNGVPFSGKYQAKIHSNGNISEGVKSTGDVYYKFEEPIECSDASDLDKSLYSGQNFVSAPLPIWDLIGRSFVIFREGEPAYDIAGVIARSAGVWENDKQVCACTGKTVWEERKDALKNNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU92</accession>
    <name>Q6FU92_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0F05335g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU92"/>
    <dbReference type="FunCoup" id="Q6FU92">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU92"/>
    <dbReference type="KEGG" id="cgr:2887930"/>
    <dbReference type="CGD" id="CAL0131010">
        <property type="gene designation" value="CAGL0F05335g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05335g"/>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004312_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FU92"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
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        </location>
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        </location>
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        </location>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUQ0</accession>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
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        </source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35408" checksum="54DF5556B618B128" modified="2004-07-19" version="1">MSKQLPITFDGENLPPQETVDLYATTFENELSPLNEETLKSQIQAVKGLLYNRDYLNAFDDQINRAAYVSRWSPSRSLCYTTLFTHLKPVYELLSQGSSHVLCVGGGAGGELVSLANIFTMANVSDNAFDGTMKVDLIDIANWDDIIQRLVTSINTKWLYQADRSQRFMVNFQNKDALMMNDIELLGDLDLITILFTANELFTEQRAPTLQFLQRLSKHCKPGCKLLIVESAGSYSHITMPSGKKFPIQFLLDTVLVGTSSSQKSKKQDREGDWDLLEQDDSTWYRGDTKVMYSLKLENMRFFYRLYQHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUX9</accession>
    <name>Q6FUX9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0E06336g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="cgr:2887383"/>
    <dbReference type="CGD" id="CAL0129022">
        <property type="gene designation" value="CAGL0E06336g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06336g"/>
    <dbReference type="eggNOG" id="KOG0090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091084_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FUX9"/>
    <dbReference type="OMA" id="CWIDERA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04105">
        <property type="entry name" value="SR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274213" description="Signal recognition particle receptor subunit beta" evidence="11">
        <location>
            <begin position="22"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0129022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="254" mass="28316" checksum="7068AAF1A4C10E57" modified="2004-07-19" version="1">MVASSLMIALVLVILTTLLIAFQVKKTLVSGHKSSQSSSYVKKVPTIIIAGPSYSGKTSLFHKLTSDETNAKLLTVMSQEPSFALKYKGTMTTLADYPGHVKLAYKLKNGIIDLKGNLKGILFVLDSTIDPKNITETAEYLTEILLILEKIREPIDILIACNKNESFTARQPLKIKEALENEITRIFERKKKSLGNIERDIGDVDEINENLDLSFDISKGFKFDYLEGNVEVLAGSVHKNKITTWQEWVGSHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV35</accession>
    <name>Q6FV35_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PEX14</name>
        <name evidence="14 15" type="ordered locus">CAGL0E05082g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445909.1">
        <property type="nucleotide sequence ID" value="XM_445909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV35"/>
    <dbReference type="FunCoup" id="Q6FV35">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV35"/>
    <dbReference type="GeneID" id="2887380"/>
    <dbReference type="KEGG" id="cgr:2887380"/>
    <dbReference type="CGD" id="CAL0129020">
        <property type="gene designation" value="PEX14"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05082g"/>
    <dbReference type="eggNOG" id="KOG2629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045718_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FV35"/>
    <dbReference type="OMA" id="YGAYEVT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000547">
        <property type="entry name" value="Peroxisomal membrane protein PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="13">
        <location>
            <begin position="6"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="143"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0129020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="380" mass="42590" checksum="322D6FD99CA7B967" modified="2004-07-19" version="1">MPVTSERKELFDSAVSFLQDSAIKDAPLDKKVEFLKSKGLGDEEVELALQEAGRRFRDAGNAASDEETATQGNLGHSLNTTTRRRQEYMYEAIPPPLPQRDWKDYFVMATMTAGLFYGVYEVTKRYVVPNLLPESTSKLEQDKEDIKKEFEKVDQILSAIQDEQADFKEKEQEKLNELDEVISDLKMALRETTNTKEKMEDDFRLLKLEITTLQNSIDKFMSDNSNVKELETLSREVMSLKNLITVAKTNKDIQNGTGGSNLSGMPGKSLSPGGLPGADSIPSAADILARMNISGVAGKSAVQDHDPNESGTEPQWKKVKDNMVDSSEFIPEWQRAKTPNDQAKLDIPEWQKAALKSDDKLDIPDWQNIKSSSQNTSEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV82</accession>
    <name>Q6FV82_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome B pre-mRNA-processing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0E04026g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV82"/>
    <dbReference type="FunCoup" id="Q6FV82">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887328"/>
    <dbReference type="CGD" id="CAL0128734">
        <property type="gene designation" value="CAGL0E04026g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04026g"/>
    <dbReference type="eggNOG" id="ENOG502RYC2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029563_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FV82"/>
    <dbReference type="OMA" id="SHKTLWS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000372">
        <property type="term" value="P:Group I intron splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016424">
        <property type="entry name" value="Cbp2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004611">
        <property type="entry name" value="CBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="74759" checksum="6E9A34E54AD06FE2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVD5</accession>
    <name>Q6FVD5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromatin structure-remodeling complex protein RSC14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0E02761g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVD5"/>
    <dbReference type="FunCoup" id="Q6FVD5">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVD5"/>
    <dbReference type="KEGG" id="cgr:2887431"/>
    <dbReference type="CGD" id="CAL0129146">
        <property type="gene designation" value="CAGL0E02761g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02761g"/>
    <dbReference type="eggNOG" id="ENOG502S2JC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1366073_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVD5"/>
    <dbReference type="OMA" id="SIDFAHY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013895">
        <property type="entry name" value="Rsc14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08586">
        <property type="entry name" value="Rsc14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22662" checksum="A23960F9433B9C00" modified="2004-07-19" version="1">MKLDYYSVIGGLGSLDRSHSVVLGPQELRELVKNTEENRSDTALPDLYRNNKERVNIHGYLGGRVDMKEVSEMTYDLNHTLLGGYVPRQQLETLCSTDFARYMHRKVDCGDAMQVYDTFLADNHLGLAQRPRIHTQTTQSPQAQSQAQGQGIAQPMQDKIPPVQHDTHVRKVVVCKRCSARFLGPSRMKSLRRHNCKAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVF4</accession>
    <name>Q6FVF4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0E02321g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVF4"/>
    <dbReference type="FunCoup" id="Q6FVF4">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVF4"/>
    <dbReference type="KEGG" id="cgr:2887547"/>
    <dbReference type="CGD" id="CAL0129072">
        <property type="gene designation" value="CAGL0E02321g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02321g"/>
    <dbReference type="eggNOG" id="KOG1325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014602_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVF4"/>
    <dbReference type="OMA" id="GPEQYSL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07203">
        <property type="entry name" value="cPLA2_Fungal_PLB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000010">
        <property type="entry name" value="Lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005143975" description="Lysophospholipase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="681"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="32"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0129072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="704" mass="78515" checksum="2DFB768A025CA693" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVG2</accession>
    <name>Q6FVG2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0E02123g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVG2"/>
    <dbReference type="FunCoup" id="Q6FVG2">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVG2"/>
    <dbReference type="KEGG" id="cgr:2887396"/>
    <dbReference type="CGD" id="CAL0128992">
        <property type="gene designation" value="CAGL0E02123g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02123g"/>
    <dbReference type="eggNOG" id="KOG3429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FVG2"/>
    <dbReference type="OMA" id="WYNSFDA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016150">
        <property type="term" value="F:translation release factor activity, codon nonspecific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052104">
        <property type="entry name" value="Mito_Release_Factor_mL62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075:SF54">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11075">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110916">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="2">
        <location>
            <begin position="31"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="190" mass="21864" checksum="A5591D45F0CF1220" modified="2004-07-19" version="1">MLFTKVLYRRADRFASARQWVRELRVSDVPVSIYRVRYDRSSGPGGQNVNKVSTKCTLTIPGISRCEWFPSEVRGLLTKGVCVANPDESNAKQIVASTLSGRPSSYYYPANDKFIVRADETRSREQNRRLCLDKLVREIQDTCRFPGVENEATVSKWDSIKKQTNKIRLEGKRQVSEKKSARKKPRLDLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVR6</accession>
    <name>ALG13_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>UDP-N-acetylglucosamine transferase subunit ALG13</fullName>
            <ecNumber>2.4.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Asparagine-linked glycosylation protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ALG13</name>
        <name type="ordered locus">CAGL0D06270g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UDP-N-acetyl-alpha-D-glucosamine = an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23380"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.4.1.141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer with ALG14 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.141"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445678.1">
        <property type="nucleotide sequence ID" value="XM_445678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVR6"/>
    <dbReference type="SMR" id="Q6FVR6"/>
    <dbReference type="FunCoup" id="Q6FVR6">
        <property type="interactions" value="348"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVR6"/>
    <dbReference type="EnsemblFungi" id="CAGL0D06270g-T">
        <property type="protein sequence ID" value="CAGL0D06270g-T-p1"/>
        <property type="gene ID" value="CAGL0D06270g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886968"/>
    <dbReference type="KEGG" id="cgr:2886968"/>
    <dbReference type="CGD" id="CAL0128497">
        <property type="gene designation" value="CAGL0D06270g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D06270g"/>
    <dbReference type="eggNOG" id="KOG3349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085408_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FVR6"/>
    <dbReference type="OMA" id="ILDAWKM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098548">
        <property type="term" value="C:cytoplasmic side of Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052474">
        <property type="entry name" value="UDP-GlcNAc_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47043:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000215599" description="UDP-N-acetylglucosamine transferase subunit ALG13">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="198" mass="22088" checksum="E1D2AE1B235476E8" modified="2004-07-19" version="1">MSAFVTCGATVPFPALVEAVLAPEFVGCLSREGYRVLCVQFGRGYDFEAQFTSVTCTRMPLESAEVSELRQLVRDERVTVMGYKVQDVVVLGFAYSNNILQIIDRYGDVVISHAGTGSILDSLRLNKKLIVVVNHTLMDNHQKQIAEKFQNLGHILATNPTAIELCDAMKRLKHEDLIPLSSETNTEFMERLKSIAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVS0</accession>
    <name>Q6FVS0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0D06160g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TFS-II family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVS0"/>
    <dbReference type="FunCoup" id="Q6FVS0">
        <property type="interactions" value="1019"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVS0"/>
    <dbReference type="KEGG" id="cgr:2887111"/>
    <dbReference type="CGD" id="CAL0127985">
        <property type="gene designation" value="CAGL0D06160g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D06160g"/>
    <dbReference type="eggNOG" id="KOG1105">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037637_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FVS0"/>
    <dbReference type="OMA" id="RFVVMTH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000007">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="16">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="17">
        <location>
            <begin position="145"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="15">
        <location>
            <begin position="264"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="80"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0127985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG58585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="306" mass="34551" checksum="3E8EE743BCDD7197" modified="2004-07-19" version="1">MMDAKDVVVHVRNLEKSKGNDESVLEILRILEKEVVPTEKLLRETKVGVEVNKFKKSENAEISKLVKRMIGAWKDAINKHKKAKLRQQQPPQQGVSASSGGAADGSNNDGAKSGDEPRKTDKFVSSKIRNTKNDGVDPNVHNNKLRDQVIRALYDALAKDSEHPPKSILQTSIAIEEEMHKLNDSSIKEKEYKDKYRVIYSNIISRNNPDLKVKIANGDLSPEQLVNSDPKDLAPEHLKKKMEEIKKQNLFNAQGATIERSVTDRFTCGKCKEKKVSYYQLQTRSADEPLTTFCTCEACGNRWKFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW60</accession>
    <name>AIM18_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 18, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM18</name>
        <name type="synonym">FMP22</name>
        <name type="ordered locus">CAGL0D02728g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIM18/AIM46 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445534.1">
        <property type="nucleotide sequence ID" value="XM_445534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW60"/>
    <dbReference type="SMR" id="Q6FW60"/>
    <dbReference type="FunCoup" id="Q6FW60">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW60"/>
    <dbReference type="EnsemblFungi" id="CAGL0D02728g-T">
        <property type="protein sequence ID" value="CAGL0D02728g-T-p1"/>
        <property type="gene ID" value="CAGL0D02728g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887105"/>
    <dbReference type="CGD" id="CAL0128039">
        <property type="gene designation" value="CAGL0D02728g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_D02728g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02728g"/>
    <dbReference type="eggNOG" id="ENOG502RGD3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038840_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW60"/>
    <dbReference type="OMA" id="PENSHQD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.890.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016089">
        <property type="entry name" value="Chalcone_isomerase_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000399550" description="Altered inheritance of mitochondria protein 18, mitochondrial">
        <location>
            <begin position="31"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="309" mass="34236" checksum="2E8F16CEEC5CDA2C" modified="2004-07-19" version="1" precursor="true">MLRTLVRRSLIKNTGLATRATRLSAVTKRLQSSAPKPATEKSDKKAWWIVGLVSAAFAGGTYVCTWEREELQKERDGKSVLVDDAVTPFPVVISRPTYPLSTKYDILGSGIRSVSVLTFKAYALGIYIARQDKPKVAQVFDSTFMSKNFIDMDENKSHAENVKIALDDPEKSRILIDNLLDSNIRMVAKLTPIKNASAKLLKEGIIKNVQMHPDASKNKETLAMGIKEVEEAIKIKGPVPKDDDFLMELLADGSLKFSYYNRRKDIVNELGTVHQPLVGKYLFAQYLSGSNPVSPGTKDQCAETLASLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWB2</accession>
    <name>Q6FWB2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0D01540g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445482.1">
        <property type="nucleotide sequence ID" value="XM_445482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWB2"/>
    <dbReference type="FunCoup" id="Q6FWB2">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWB2"/>
    <dbReference type="KEGG" id="cgr:2887170"/>
    <dbReference type="CGD" id="CAL0128189">
        <property type="gene designation" value="CAGL0D01540g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01540g"/>
    <dbReference type="eggNOG" id="ENOG502S6JB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129456_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FWB2"/>
    <dbReference type="OMA" id="RNKFIGW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28038:SF1">
        <property type="entry name" value="ADL329WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="127" mass="14232" checksum="86E974111581F251" modified="2004-07-19" version="1">MALNNVRRQDLCVQYKKSEPPRGIYSESQSLSGIVNQTMPMAAIFLKNKFIAWFSLIQSVHSYLNTDEETLEKNKSKTGNSALDQPPLVKVAMSLVGILVCYMNLVFPTPDAPPPSSEKKILDEEKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWE1</accession>
    <name>RAD59_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>DNA repair protein RAD59</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RAD59</name>
        <name type="ordered locus">CAGL0D00902g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with RAD51 and RAD52.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445453.1">
        <property type="nucleotide sequence ID" value="XM_445453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWE1"/>
    <dbReference type="SMR" id="Q6FWE1"/>
    <dbReference type="FunCoup" id="Q6FWE1">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWE1"/>
    <dbReference type="EnsemblFungi" id="CAGL0D00902g-T">
        <property type="protein sequence ID" value="CAGL0D00902g-T-p1"/>
        <property type="gene ID" value="CAGL0D00902g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887211"/>
    <dbReference type="KEGG" id="cgr:2887211"/>
    <dbReference type="CGD" id="CAL0128311">
        <property type="gene designation" value="CAGL0D00902g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00902g"/>
    <dbReference type="eggNOG" id="KOG4141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091426_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWE1"/>
    <dbReference type="OMA" id="WSVQRIG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006277">
        <property type="term" value="P:DNA amplification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000278">
        <property type="term" value="P:regulation of DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016810">
        <property type="entry name" value="Rad59"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022936">
        <property type="entry name" value="RAD59_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000173895" description="DNA repair protein RAD59">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="212" mass="23318" checksum="D8A1914A95FF8B45" modified="2004-07-19" version="1">MDGKVTYEGAVYSSGPGVEVGDIVFVEDWDGRPASEWSVQRIGVLQSKIERYTYQIYHSNRYGKHNLSKLIPRHVLVGFANEVFGFDGWKTDIEFVETKDGFPGSTSSISIADKISADSGGGTGALADRYTVIAEASVKVTLKDGTNTRMTGFSRATTPSKIESFNKAKKEAVNDALKKALLSFEKIILEHELKTKNDFYVDGLYGSKAQKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWH9</accession>
    <name>AIM6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM6</name>
        <name type="ordered locus">CAGL0C05533g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWH9"/>
    <dbReference type="FunCoup" id="Q6FWH9">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="GeneID" id="2886874"/>
    <dbReference type="KEGG" id="cgr:2886874"/>
    <dbReference type="eggNOG" id="ENOG502QVA8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031561_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FWH9"/>
    <dbReference type="OMA" id="HANYLTT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000408706" description="Altered inheritance of mitochondria protein 6">
        <location>
            <begin position="30"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="411" mass="46744" checksum="632BB6BDA59F1CA8" modified="2004-07-19" version="1" precursor="true">MIPFTAQYLLVCGYVILLGVILLERSGYSAFGLLEKRQDYFHNSHAIMLSSRQDLGVSGPALYELFEKHLLDAYRIPGRYPGGISTLYDTFSEYVFKGTSHENCSVETSAVAKLTRDVTPLPIHSHNDYWRDVPLLKGLAYGSVSTEADVWVHPHKDHPYNSSTDKLEDYVLAVGHDEDYIDPLRKTLEKLYTDPLQSLLEGVNCGKSNNSKTQKNGVFYTANHIPLFFYIDFKSDDNILTYKLLLEKYFTQLIQAGYLTYYDMDTGKIIQGQVTVIMTGNYPNNTDVLDNGKADGYFGDRKRYLLQDANLLELNEESAKMAVTASTSLSEILKMVGSSNLKVIMRGHLDKEEITAIKKYIDNAHSFDLKTRIWGVPSWPRKTMKRLWKQQIEDLNSDFLNVDDLKAAAMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWI4</accession>
    <name>Q6FWI4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0C05423g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="3"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWI4"/>
    <dbReference type="FunCoup" id="Q6FWI4">
        <property type="interactions" value="977"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWI4"/>
    <dbReference type="KEGG" id="cgr:2886944"/>
    <dbReference type="CGD" id="CAL0127346">
        <property type="gene designation" value="CAGL0C05423g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05423g"/>
    <dbReference type="eggNOG" id="KOG0789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001645_9_1_1"/>
    <dbReference type="InParanoid" id="Q6FWI4"/>
    <dbReference type="OMA" id="TMICGNI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000115">
        <property type="entry name" value="Tyrosine-protein phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016277">
        <property type="entry name" value="Ptp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000938">
        <property type="entry name" value="PTPN1_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="228"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0127346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="337" mass="39702" checksum="84FDCDDA5A3B6F06" modified="2004-07-19" version="1">MRPWYIDQPDVELLRKFKFIQNQEDERLREATIVTADVEVEKRWSLGVSILEKNDARNRYVNIMPYERNRVKLKVVNPRINNDYINASYVKVDVPEQSMNPGYYIATQGPTKNTWQQFWQMCYNECNHGDIVIVMVTPLVEYNREKCYKYWPSSPKEGIFVSPKLQNPSGLDGDVSEFRDELSIEYIDSERIDDTYTYTKLKIVSQGGSEKNVHHFYFDQWRDMSKPEEIVPIMKLCEHSHGLNPRGNPIIVHCSAGVGRSGTFIALDHLVHDTHDFKNVSEFPTIQQLRKPLADYKRDLIEQIVLQLRSQRMKMVQMKDQYIFIYHAAKYLYDMIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWL9</accession>
    <name>Q6FWL9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0C04609g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWL9"/>
    <dbReference type="FunCoup" id="Q6FWL9">
        <property type="interactions" value="587"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWL9"/>
    <dbReference type="MEROPS" id="C12.002"/>
    <dbReference type="KEGG" id="cgr:2886948"/>
    <dbReference type="CGD" id="CAL0127636">
        <property type="gene designation" value="CAGL0C04609g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04609g"/>
    <dbReference type="eggNOG" id="KOG1415">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054406_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FWL9"/>
    <dbReference type="OMA" id="AQTYSKH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057254">
        <property type="entry name" value="UCH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00140">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0127636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="246" mass="26626" checksum="D3710BB7EF9D984A" modified="2004-07-19" version="1">MAAVVPMESSPEVFNHVAHLLGLDNAHAFVDVYSLDDPDLLAMVPRPVSAIVLLFPLTEGLREPIASGDAGKGRDNGSDNGSEAGNGSGVSWFRQSIKNACGLYAVLHALSNNKEILEPTSVLGNFLESHSAMRFDDEQTNKFVLDAADKYRETFTMGSTSYPQDVDPSQIEVNLHFVTYVVQNGHVYELDGRRAGPLDLGTADDSASDILAQPLLKSRIQELMSAAQNSQDSLNFSILGLTEAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX41</accession>
    <name>Q6FX41_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0C00495g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX41"/>
    <dbReference type="FunCoup" id="Q6FX41">
        <property type="interactions" value="656"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX41"/>
    <dbReference type="KEGG" id="cgr:2886750"/>
    <dbReference type="CGD" id="CAL0127208">
        <property type="gene designation" value="CAGL0C00495g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00495g"/>
    <dbReference type="eggNOG" id="KOG3484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140546_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FX41"/>
    <dbReference type="OMA" id="RPINYGQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000002">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0127208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="128" mass="15121" checksum="C222467FAD34F8D4" modified="2004-07-19" version="1">MYNHYHTFEGRKLTEQERARVLEFQESIHYSPRYSDDTHEYRHVMLPKAMLKVIPSDYFNSEVGTLRILTEDEWRGLGITQSLGWEHYECHAPEPHILLFKRPLNYEAEYRAAAAAAAASQQHQQDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXQ0</accession>
    <name>Q6FXQ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0B04015g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXQ0"/>
    <dbReference type="FunCoup" id="Q6FXQ0">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXQ0"/>
    <dbReference type="KEGG" id="cgr:2886533"/>
    <dbReference type="CGD" id="CAL0127700">
        <property type="gene designation" value="CAGL0B04015g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04015g"/>
    <dbReference type="eggNOG" id="KOG2804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXQ0"/>
    <dbReference type="OMA" id="FAHIYTG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="108"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="331"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0127700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="402" mass="46512" checksum="67308B5A81657B5C" modified="2004-07-19" version="1">MAKLSRTTSLKKRLSNSSFTKLFKAKRKREDDEDSTTDSADHEETPGKENREIATPSAKRHRPISKEQQEFEKKEALLDAELPEELRKYRPKGFRLNIPPKDRPIRIYADGIFDLFHLGHMKQLEQCKKAFPNVELVCGIPSDEVTHKLKGLTVLTDKQRCETLMHCKWVDEVVPNAPWCVTPEFLAEHKIDYVAHDDIPYVSSDSDDIYKPIKELGKFLTTQRTDGISTSDIITKIIRDYDKYLMRNFARGATRQELNVSWLKKNELEFKKHISDFRSYFKKNQGNLNNASRDLYFEVREILLRKTLGRKLYSKLLGDKHIPRSIALGSLSATSDEEEQSDDLPEPKRKKMLLIREPSPATEFASKYTGAKVTKQESEEDAESEDINDEDDEEEADEEDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXY6</accession>
    <name>Q6FXY6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MIG1</name>
        <name evidence="15 16" type="ordered locus">CAGL0A01628g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444836.1">
        <property type="nucleotide sequence ID" value="XM_444836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXY6"/>
    <dbReference type="SMR" id="Q6FXY6"/>
    <dbReference type="FunCoup" id="Q6FXY6">
        <property type="interactions" value="657"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXY6"/>
    <dbReference type="GeneID" id="2886361"/>
    <dbReference type="KEGG" id="cgr:2886361"/>
    <dbReference type="CGD" id="CAL0126537">
        <property type="gene designation" value="MIG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01628g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047856_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXY6"/>
    <dbReference type="OMA" id="KRIHTNP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900436">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000045">
        <property type="entry name" value="ZFP69 zinc finger protein B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="322"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0126537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG57729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="424" mass="46418" checksum="275BD3602E50539C" modified="2004-07-19" version="1">MSASASPEPHTPENNPSSVTNGSSTPNSGKSKAGKGDDAPRPHVCPICGRAFHRLEHQTRHMRTHTGEKPHACDFPGCVKRFSRSDELTRHRRIHTNPLPKGKRGRKKKPETILAEQRAREEAERNKNNPNYKPPSKSSLRRKTKRNTTFELGESTPSSSLTPPQQPNPQVQLPSSPMVGDETTNAPHSDGMTPIEPQRFLSSPPNHVRPVFGSANNSNSSSRIRLNALSSLQMMTPLSGRNSSSTMNLSQQASTTFLDNPDGSKNQNIILPRPKSLTDFASMHANGSSTNLTTLMQQPNMGNLMKRPNSVLSLNELVTQSGAGTHGYDTGNNSSLEEDDLKDPELENDQLRKKSKTATPTTGLSRSASGLNLSLKTKSLTNMQDMNKVNEKLLQYQKNVVSPQIAPQDGLPPLRSLHLQFPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY59</accession>
    <name>Q6FY59_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0A02706g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY59"/>
    <dbReference type="FunCoup" id="Q6FY59">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886375"/>
    <dbReference type="CGD" id="CAL0126841">
        <property type="gene designation" value="CAGL0A02706g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02706g"/>
    <dbReference type="eggNOG" id="ENOG502QS09">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_750041_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY59"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180016">
        <property type="term" value="F:SUMO ligase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033235">
        <property type="term" value="P:positive regulation of protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17080">
        <property type="entry name" value="Ubl_SLD2_Esc2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="2">
        <location>
            <begin position="297"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0126841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG57776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="369" mass="41419" checksum="2677575C7C51C59A" modified="2004-07-19" version="1">MDFSDEDSDEFFMGTSEDVEERLQQAMASRAPQAPNAEPAPVQEPHAEAEAELEPEAEGPSQEQVRGQDVVVIEGDTEGSGSEGSSDSEGSSDSGAQDTYRGDKEYEVRTRSGMKRARTVEDENDLFFQSIAKRSQSLPVQDGSGAVRQDKVYYVQFISHVDGTKGKSVQVKALGSHPFSKLVAAALSGLMRAHRLPSVMRPLYQPESVVSYWNRAKVLGFMTCDTLRVPQRYGSDYLEIQLVPVKEEAQYLEQEVFEEPERAPTPEEDAEEEFERELRDAKEVRAPVVDLESEEVLRVALQGQDNKKVYVNVKPTTTFARMIEYYRTQKQLPRSTQITLALDDEPLDPHATVKSQDIEDEDMLEVRLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-06-28" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q8TFK7</accession>
    <accession>F2Z674</accession>
    <accession>Q6FLJ7</accession>
    <name>GEP3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Genetic interactor of prohibitins 3, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Found in mitochondrial proteome protein 38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GEP3</name>
        <name type="synonym">FMP48</name>
        <name type="ordered locus">CAGL0L02893g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Yeast" volume="19" first="991" last="994">
            <title>Genomic differences between Candida glabrata and Saccharomyces cerevisiae around the MRPL28 and GCN3 loci.</title>
            <authorList>
                <person name="Walsh D.W."/>
                <person name="Wolfe K.H."/>
                <person name="Butler G."/>
            </authorList>
            <dbReference type="PubMed" id="12125055"/>
            <dbReference type="DOI" id="10.1002/yea.890"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the mitochondrial lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AY083607">
        <property type="protein sequence ID" value="AAM08103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448897.1">
        <property type="nucleotide sequence ID" value="XM_448897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8TFK7"/>
    <dbReference type="SMR" id="Q8TFK7"/>
    <dbReference type="FunCoup" id="Q8TFK7">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q8TFK7"/>
    <dbReference type="EnsemblFungi" id="CAGL0L02893g-T">
        <property type="protein sequence ID" value="CAGL0L02893g-T-p1"/>
        <property type="gene ID" value="CAGL0L02893g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890836"/>
    <dbReference type="KEGG" id="cgr:2890836"/>
    <dbReference type="CGD" id="CAL0135692">
        <property type="gene designation" value="CAGL0L02893g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02893g"/>
    <dbReference type="eggNOG" id="ENOG502S0UP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025792_1_0_1"/>
    <dbReference type="InParanoid" id="Q8TFK7"/>
    <dbReference type="OMA" id="IIPPFYG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01855">
        <property type="entry name" value="YqeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000409631" description="Genetic interactor of prohibitins 3, mitochondrial">
        <location>
            <begin position="15"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="CP-type G" evidence="3">
        <location>
            <begin position="105"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01058"/>
        </source>
    </evidence>
    <sequence length="526" mass="61413" checksum="F6DCAF8762CEB6EE" modified="2002-06-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>B4UMZ4</accession>
    <name>B4UMZ4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">HTZ1</name>
        <name evidence="13 14" type="ordered locus">CAGL0E02315g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAR58018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002999536.1">
        <property type="nucleotide sequence ID" value="XM_002999490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UMZ4"/>
    <dbReference type="FunCoup" id="B4UMZ4">
        <property type="interactions" value="1253"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UMZ4"/>
    <dbReference type="GeneID" id="9487984"/>
    <dbReference type="KEGG" id="cgr:9487984"/>
    <dbReference type="CGD" id="CAL0129048">
        <property type="gene designation" value="HTZ1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02315g"/>
    <dbReference type="eggNOG" id="KOG1757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062828_2_1_1"/>
    <dbReference type="InParanoid" id="B4UMZ4"/>
    <dbReference type="OMA" id="MNKKGAP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140898">
        <property type="term" value="P:CENP-A eviction from euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0129048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAR58018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="133" mass="14221" checksum="5F648BA630F9415E" modified="2008-09-23" version="1">MSGKMHGGKGKSGAKDGMRAQSSSARAGLQFPVGRIKRYLKRSASGKARVGSKAAIYLTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDDELDSLIRATIASGGVLPHINKALLLKVEMGKKNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN03</accession>
    <name>B4UN03_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prefoldin subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0G07529g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAR58027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN03"/>
    <dbReference type="FunCoup" id="B4UN03">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UN03"/>
    <dbReference type="KEGG" id="cgr:9487996"/>
    <dbReference type="CGD" id="CAL0129297">
        <property type="gene designation" value="CAGL0G07529g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07529g"/>
    <dbReference type="eggNOG" id="ENOG502S3UF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122140_1_1_1"/>
    <dbReference type="InParanoid" id="B4UN03"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="12"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0129297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAR58027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12377" checksum="CCA538EEBB3A024F" modified="2008-09-23" version="1">MSTQAQEMATTLRMNKGQLEIVEQQLSQLERQQKFAQATAKELESYPTETVWRSCGRAFVLQDKDSYIKDLGTDEKTLEEQAKALRIKKNYLDVSIEKTVAGLKSMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN08</accession>
    <name>B4UN08_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0H04691g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAR57988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN08"/>
    <dbReference type="FunCoup" id="B4UN08">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UN08"/>
    <dbReference type="KEGG" id="cgr:9488002"/>
    <dbReference type="CGD" id="CAL0131680">
        <property type="gene designation" value="CAGL0H04691g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04691g"/>
    <dbReference type="eggNOG" id="KOG3505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_1_2_1"/>
    <dbReference type="InParanoid" id="B4UN08"/>
    <dbReference type="OMA" id="TQVRYDP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0131680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAR57988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="70" mass="7957" checksum="11CD728BDADBD3DD" modified="2008-09-23" version="1">MAKVKAKNTVVKLVSTALTGYSRFISVKKGAPLVTQVRYDPIAKKHVLFKESKKRKVPERKPLDFLRTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-31" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>F2Z6C1</accession>
    <name>F2Z6C1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0G05401g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446595.1">
        <property type="nucleotide sequence ID" value="XM_446595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F2Z6C1"/>
    <dbReference type="FunCoup" id="F2Z6C1">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="284593.F2Z6C1"/>
    <dbReference type="KEGG" id="cgr:2888232"/>
    <dbReference type="CGD" id="CAL0130330">
        <property type="gene designation" value="CAGL0G05401g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05401g"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018359_0_0_1"/>
    <dbReference type="InParanoid" id="F2Z6C1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12245">
        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000089">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="544"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="625"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="656"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0130330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="671" mass="72239" checksum="3B3224DE8F749353" modified="2011-05-31" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIT9</accession>
    <name>PRP45_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-processing protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PRP45</name>
        <name type="ordered locus">CAGL0M11814g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNW family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449855.1">
        <property type="nucleotide sequence ID" value="XM_449855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIT9"/>
    <dbReference type="SMR" id="Q6FIT9"/>
    <dbReference type="FunCoup" id="Q6FIT9">
        <property type="interactions" value="1070"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIT9"/>
    <dbReference type="EnsemblFungi" id="CAGL0M11814g-T">
        <property type="protein sequence ID" value="CAGL0M11814g-T-p1"/>
        <property type="gene ID" value="CAGL0M11814g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891250"/>
    <dbReference type="KEGG" id="cgr:2891250"/>
    <dbReference type="CGD" id="CAL0136955">
        <property type="gene designation" value="CAGL0M11814g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11814g"/>
    <dbReference type="eggNOG" id="KOG2441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006601_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FIT9"/>
    <dbReference type="OMA" id="EDQVYDN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000084817" description="Pre-mRNA-processing protein 45">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="414" mass="46265" checksum="0D5FFED34A2E435D" modified="2004-07-19" version="1">MSFSSLLPPPEHSPPDDVNSREVEIITKEHDFIVNALTKKEAVHSSNNNIGSFVGSQVANFNDVIPLRQKDFYGVQAPLPTTQEIELCKVRTQEVVNRLLHKFTDKGKAGYQKDTRKITTGSRIITIESKRQDPLQPSRQKNTSSKIVLPEDDETDTPILHATDDAKSKRLTKEERAKWNIPAAVSSWKNPMGYTVGLKHRAAHGKKTGNVGSINNKVSDIVAALDETDQEIREGIQQENELKRKQLKEEERIKEEKLRAIAERSKIQTQSSAVKKRGSRFEGGRHQNKKIKKEEPPIKSAAERLKELAYAQGREVSEKVILGAAKATTTGTGANVHYDSRLFSKGANAAAKRSEEQVYDNPLFVQQEIDSIYRVNAKSIDEANSVSASRYGPIQFTKAHSLDDKSTAKDEEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIX3</accession>
    <name>Q6FIX3_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M11044g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449821.1">
        <property type="nucleotide sequence ID" value="XM_449821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIX3"/>
    <dbReference type="STRING" id="284593.Q6FIX3"/>
    <dbReference type="KEGG" id="cgr:2891389"/>
    <dbReference type="CGD" id="CAL0137395">
        <property type="gene designation" value="CAGL0M11044g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11044g"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729573_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIX3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="162"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="6">
        <location>
            <begin position="255"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0137395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="379" mass="44140" checksum="AEBD68D8187A16CD" modified="2004-07-19" version="1">MSLANLYMCSVACAINLNINFTMDSKIIKNYLLPKAIYKPGNKIGATIFNDNRTINNKLPLSLEKNANSLNIMDNTNVLKSVLKNYKCNKSLPYSSLIDKENISNESSQIHIAKENSEVDLCNTTLDNAYEYLLKLDEDTYLPDTILNEYSSLRQTRDLLLNWVIKIHQNLKLENETLYMTIDLIDKFLIKKKLPIEKFQLLGLTCLYIASKYEEVLPPSIFQFALESNGIFDSEEIKESEFNILETLNFKIGYPSPIVLLDRQLDGYLNYNEMKFMSLYLLEITFVDFRFLSYRMSMRTKAAALITLKMYNHSIKDLKTRFQKEGLMQTIEKICRYILQYLLEPTIHTELQRKYSQLASYNVADRATKYVKCLIKKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIZ8</accession>
    <name>Q6FIZ8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M10329g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIZ8"/>
    <dbReference type="FunCoup" id="Q6FIZ8">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIZ8"/>
    <dbReference type="KEGG" id="cgr:2891360"/>
    <dbReference type="CGD" id="CAL0136401">
        <property type="gene designation" value="CAGL0M10329g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M10329g"/>
    <dbReference type="eggNOG" id="KOG4708">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126331_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FIZ8"/>
    <dbReference type="OMA" id="RGVQYWG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000007">
        <property type="entry name" value="37S ribosomal protein Mrp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="118" mass="13679" checksum="D18B305422D11212" modified="2004-07-19" version="1">MLYELIAMVRILQPKHQMQQEAKELATTIGRMIIENRGVVRKIMPMGKTMLPRVITKDQERHFQAFKFLMLFDSSIPVQSQILRTLRKDPRVIRSSIVKINTEKELASLSSIEKSQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ44</accession>
    <name>Q6FJ44_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermembrane space cysteine motif-containing protein MIX23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M09339g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ44"/>
    <dbReference type="FunCoup" id="Q6FJ44">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891314"/>
    <dbReference type="CGD" id="CAL0136627">
        <property type="gene designation" value="CAGL0M09339g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09339g"/>
    <dbReference type="eggNOG" id="ENOG502S17Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118733_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ44"/>
    <dbReference type="OMA" id="QFCFNER"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903955">
        <property type="term" value="P:positive regulation of protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016805">
        <property type="entry name" value="MIX23_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022603">
        <property type="entry name" value="UCP022603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="23556" checksum="D157C2A29BEF0363" modified="2004-07-19" version="1">MAKQGQEELTVSFSEQLLDPNLSFPDYQQTTRQLTLNRARCVDPTLIDTFLRNLRHGSDDVIKQKLNNYSKQTEHRNDTRLQKCDSLIHREIYPNWQVRDSIIDFCAAQATQLKYELDQQKSSEVIRTTVDTRLDPYSVRDLQHEEEKKYKQWNDLNNWVENNRTIEGILRGSSDHFLKQNCDQNVDYLRKFWDLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ89</accession>
    <name>Q6FJ89_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M08272g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ89"/>
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        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891264"/>
    <dbReference type="CGD" id="CAL0137109">
        <property type="gene designation" value="CAGL0M08272g"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_5_3_1"/>
    <dbReference type="InParanoid" id="Q6FJ89"/>
    <dbReference type="OMA" id="LLMAQYT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:polyamine transmembrane transporter activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:amino acid transport"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
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        <property type="entry name" value="Amino_acid_permease_CS"/>
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    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="326"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="79"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0137109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="621" mass="69688" checksum="79A839B9C42D77A6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJP4</accession>
    <name>Q6FJP4_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0M04653g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG62526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene designation" value="CAGL0M04653g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04653g"/>
    <dbReference type="eggNOG" id="KOG2034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003488_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJP4"/>
    <dbReference type="OMA" id="KFFVFPC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035542">
        <property type="term" value="P:regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099022">
        <property type="term" value="P:vesicle tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="8">
        <location>
            <begin position="1"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="604"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="9">
        <location>
            <begin position="859"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0136565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="959" mass="111253" checksum="9AFF3DBBC176961E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-06-26" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJQ9</accession>
    <name>ACE2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Cell wall transcription factor ACE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ACE2</name>
        <name type="ordered locus">CAGL0M04323g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Eukaryot. Cell" volume="3" first="546" last="552">
            <title>Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence.</title>
            <authorList>
                <person name="Kamran M."/>
                <person name="Calcagno A.M."/>
                <person name="Findon H."/>
                <person name="Bignell E."/>
                <person name="Jones M.D."/>
                <person name="Warn P."/>
                <person name="Hopkins P."/>
                <person name="Denning D.W."/>
                <person name="Butler G."/>
                <person name="Rogers T."/>
                <person name="Muhlschlegel F.A."/>
                <person name="Haynes K."/>
            </authorList>
            <dbReference type="PubMed" id="15075283"/>
            <dbReference type="DOI" id="10.1128/EC.3.2.546-552.2004"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="Proteomics" volume="5" first="1838" last="1848">
            <title>Proteomic changes associated with inactivation of the Candida glabrata ACE2 virulence-moderating gene.</title>
            <authorList>
                <person name="Stead D."/>
                <person name="Findon H."/>
                <person name="Yin Z."/>
                <person name="Walker J."/>
                <person name="Selway L."/>
                <person name="Cash P."/>
                <person name="Dujon B.A."/>
                <person name="Hennequin C."/>
                <person name="Brown A.J."/>
                <person name="Haynes K."/>
            </authorList>
            <dbReference type="PubMed" id="15825152"/>
            <dbReference type="DOI" id="10.1002/pmic.200401064"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Infect. Immun." volume="74" first="5244" last="5248">
            <title>Different consequences of ACE2 and SWI5 gene disruptions for virulence of pathogenic and nonpathogenic yeasts.</title>
            <authorList>
                <person name="MacCallum D.M."/>
                <person name="Findon H."/>
                <person name="Kenny C.C."/>
                <person name="Butler G."/>
                <person name="Haynes K."/>
                <person name="Odds F.C."/>
            </authorList>
            <dbReference type="PubMed" id="16926418"/>
            <dbReference type="DOI" id="10.1128/IAI.00817-06"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2010" name="Proteomics" volume="10" first="212" last="223">
            <title>Impact of the transcriptional regulator, Ace2, on the Candida glabrata secretome.</title>
            <authorList>
                <person name="Stead D.A."/>
                <person name="Walker J."/>
                <person name="Holcombe L."/>
                <person name="Gibbs S.R."/>
                <person name="Yin Z."/>
                <person name="Selway L."/>
                <person name="Butler G."/>
                <person name="Brown A.J."/>
                <person name="Haynes K."/>
            </authorList>
            <dbReference type="PubMed" id="19941307"/>
            <dbReference type="DOI" id="10.1002/pmic.200800706"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 8">Transcription factor involved in the RAM (regulation of ACE2 transcription factor and polarized morphogenesis) signaling network that regulates polarized morphogenesis. Regulates expression of genes involved in cell separation or other cell wall genes. Required for regulation of morphogenesis, cell separation, adherence, biofilm formation, invasion, as well as virulence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Localized in the nuclei of daughter cells.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="5 7">Leads to systemic infections characterized by fungal escape from the vasculature, tissue penetration, proliferation in vivo, and considerable overstimulation of the pro-inflammatory arm of the innate immune response.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449535.1">
        <property type="nucleotide sequence ID" value="XM_449535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJQ9"/>
    <dbReference type="SMR" id="Q6FJQ9"/>
    <dbReference type="FunCoup" id="Q6FJQ9">
        <property type="interactions" value="638"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJQ9"/>
    <dbReference type="EnsemblFungi" id="CAGL0M04323g-T">
        <property type="protein sequence ID" value="CAGL0M04323g-T-p1"/>
        <property type="gene ID" value="CAGL0M04323g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891544"/>
    <dbReference type="KEGG" id="cgr:2891544"/>
    <dbReference type="CGD" id="CAL0136273">
        <property type="gene designation" value="ACE2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M04323g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04323g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021006_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJQ9"/>
    <dbReference type="OMA" id="FQHTPTK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000122">
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0060196">
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:2001043">
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcriptional factor SWI5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF144">
        <property type="entry name" value="METALLOTHIONEIN EXPRESSION ACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0130">Cell adhesion</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="523"/>
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        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 2" evidence="3">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type 3" evidence="3">
        <location>
            <begin position="581"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="333"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="465"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="599"/>
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    </feature>
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        <location>
            <begin position="148"/>
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    </feature>
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            <begin position="197"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="312"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
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            <begin position="466"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="622"/>
            <end position="634"/>
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    </feature>
    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PubMed" id="15075283"/>
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        <source>
            <dbReference type="PubMed" id="15825152"/>
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        <source>
            <dbReference type="PubMed" id="16926418"/>
        </source>
    </evidence>
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            <dbReference type="PubMed" id="19941307"/>
        </source>
    </evidence>
    <sequence length="703" mass="79480" checksum="E0960AA4A2AAF171" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJT1</accession>
    <name>Q6FJT1_CANGA</name>
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        <recommendedName>
            <fullName evidence="10">Bax inhibitor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M03839g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJT1"/>
    <dbReference type="FunCoup" id="Q6FJT1">
        <property type="interactions" value="653"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJT1"/>
    <dbReference type="KEGG" id="cgr:2891523"/>
    <dbReference type="CGD" id="CAL0136307">
        <property type="gene designation" value="CAGL0M03839g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03839g"/>
    <dbReference type="eggNOG" id="KOG2322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058671_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJT1"/>
    <dbReference type="OMA" id="FGVMSLY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33691" checksum="2B99BAA99364199F" modified="2004-07-19" version="1">MSVNKNSYVPLPNESAPPPYQEEDPAPNLYNVPDDFKWSTNVSACEPLVRQQFLHRVYSILSTQLLATLSMGYLTYKWEPLREFTNSNTWLVILASIGSILTCIWLAFAPSVDDYVPEDEANYTGETETNNELRPAKAPWYYLSKRGQYAVLSVFTICEAYSLSTITLAYDPQIILSAVLITTVVIVGVSLVALSERFQFLTESATTIYFWLNWGLLLLFGMVLTGVFFGFSSKMNIFYAWFGAALFTIYLLMDTQMIFRKVRPDEEVKCAMILYVDIINLFLHILRILSSRENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK69</accession>
    <name>Q6FK69_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M00682g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK69"/>
    <dbReference type="FunCoup" id="Q6FK69">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK69"/>
    <dbReference type="KEGG" id="cgr:2891598"/>
    <dbReference type="CGD" id="CAL0136669">
        <property type="gene designation" value="CAGL0M00682g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00682g"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FK69"/>
    <dbReference type="OMA" id="TICTRLA"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF83">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="17"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="215"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="439" mass="50737" checksum="AB61FA5B7FFCC59A" modified="2004-07-19" version="1">MRPIGTMTIANPEKILEEVKSQLGVRQSLATITEKFQEELDFMLKNCKKSMLPFPQVCCRGWSEYNEPMDMLAIDFGGSVLKFAVINMPQCQMELKYELEIKSKVVDFKFFDNIVEWICNRIPINNERSLPRKFIVAITFSFPVNANNEIVAMGKGFRMSPELKGISILDILKQSFDRLEKEYSSSFTFEISNVINDSLAVHMTSKYLQSDNNDKISLILGTGVNSCFEVQYEDLPQFKKDILTQFSDDYREKVLINSEMGFLGRYSKSIEFGNFDTNIDDKMPLESITSGKWIPQILHNIIRYYNLLPMVGDEEIKYDGRLICEILSDGECPSEYLLSLWDYEVYQIIRQITKLLINRAAIYLVAAIIAIRKFVSPEIYFTKGGIDIDYVGSFLNYCQYYQERIHLHSKGMVKLQFLNDSNLYGCAITAYSNIFENRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK95</accession>
    <name>Q6FK95_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Thiamine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TNR1</name>
        <name evidence="10 11" type="ordered locus">CAGL0L13354g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449349.1">
        <property type="nucleotide sequence ID" value="XM_449349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK95"/>
    <dbReference type="FunCoup" id="Q6FK95">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK95"/>
    <dbReference type="GeneID" id="2890577"/>
    <dbReference type="KEGG" id="cgr:2890577"/>
    <dbReference type="CGD" id="CAL0135096">
        <property type="gene designation" value="TNR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L13354g"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FK95"/>
    <dbReference type="OMA" id="GLCVNMI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903089">
        <property type="term" value="F:5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043132">
        <property type="term" value="P:NAD transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015888">
        <property type="term" value="P:thiamine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000005">
        <property type="entry name" value="Thiamine transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0135096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="64904" checksum="A06E261B3AD73C3D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKA9</accession>
    <name>Q6FKA9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L13024g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKA9"/>
    <dbReference type="FunCoup" id="Q6FKA9">
        <property type="interactions" value="728"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKA9"/>
    <dbReference type="KEGG" id="cgr:2890585"/>
    <dbReference type="CGD" id="CAL0135738">
        <property type="gene designation" value="CAGL0L13024g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L13024g"/>
    <dbReference type="eggNOG" id="KOG4401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073383_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FKA9"/>
    <dbReference type="OMA" id="QFWLEID"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048478">
        <property type="entry name" value="LSM12_LSM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016521">
        <property type="entry name" value="RNA-processing_Lsm12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21166">
        <property type="entry name" value="LSM12_LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007783">
        <property type="entry name" value="UCP007783_YHR121w"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="82"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="185" mass="21042" checksum="5410E945CC239CF2" modified="2004-07-19" version="1">MSFSLEQALGFRVKITNLLHDVIDGKIYSYNSMSNTLTIQLPKKNNANPSFKIIKCSFIKSLEVIGDKPPYNSFKRQQIKPSTVSVERVQKLLNTRIEEAKREADMKKRGITAEGQYIFDALSKTVSDTRWDGKNIVVLDDIIIASPYKQENVKSLNTHGNQSLNLIHKILERSWKELESTKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKQ7</accession>
    <name>Q6FKQ7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0L09537g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449187.1">
        <property type="nucleotide sequence ID" value="XM_449187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKQ7"/>
    <dbReference type="STRING" id="284593.Q6FKQ7"/>
    <dbReference type="KEGG" id="cgr:2891136"/>
    <dbReference type="CGD" id="CAL0135804">
        <property type="gene designation" value="CAGL0L09537g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09537g"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKQ7"/>
    <dbReference type="OMA" id="YLQLMAF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="16"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0135804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="400" mass="45348" checksum="0F648C06F89C4260" modified="2004-07-19" version="1">MPFKHDFTPVALKDTNLFKPLKVGNTEVLQRVAMAPLSRFRADPQGNVPNKNWTEEYYRQRSQRPGTMIITEATFISAQAGGYDAAPGIWTEEQMEQWKKIFKAIHDNKSFVWVQMWALGRQAFPNNMARDGLRLDAPSADLYMSDKQKEVAKENNIAQHELTKEDIKQYIKDYVKAAKNSVESGADGVEIHSANGYLLNQFIDPKSNRRTDEYGGSIENRCRFALEVVDAVVDAIGAERTGIRLSPYGLFGNMSGGFEPSIVAHYAYLIGELEKRGIAGKRLAYIHLVEPSVTDLMLVEDQGEYKEGTNDFAYSIWKGPIIRAGNYALHPELVKEQVKDPRTLIAYGRYFISNPDIIDRLENGLPLNEQDRPTFYTPTAEGYIDYPNYNDALQLGWDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKS3</accession>
    <name>Q6FKS3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-methylcitrate dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0L09108g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKS3"/>
    <dbReference type="FunCoup" id="Q6FKS3">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKS3"/>
    <dbReference type="KEGG" id="cgr:2891103"/>
    <dbReference type="CGD" id="CAL0136124">
        <property type="gene designation" value="CAGL0L09108g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09108g"/>
    <dbReference type="eggNOG" id="ENOG502QPZI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021803_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKS3"/>
    <dbReference type="OMA" id="DHSVMYI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="41"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="316"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0136124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57171" checksum="D72751072AA41DDE" modified="2004-07-19" version="1">MLAKSLKPIVQRGLSLTMRNSSNLAAVKVNDRPDPDLVLVDIAEYVHHHKIDSKLAFDTARYCLLDTLGCGLAALKYNQVQNMIKPIVPGMIVPNGVKVIGTDHVMDPIKGAFAIGTIIRWLDFNDCWLAAEWGHPSDNLGGILAVADYESRLYKATEGREGKLFKVRDVLTAMIKAHEIQGVFALDNSFNRVGLDHVILVKVATTAVVSQMLGLTSEQTIEAVSQAFVDGQSLRTYRHAPNTGSRKSWAAGDAVSRAVNLCYLVKNAGVGTIPSVLTAKTWGFYDVLFKGEAFHFNQRTSFESYVMENILFKISFPAEFHAQTAVECAMIAHNMLKEKNKTYKDIKSVRIRTQEAAARIIDKDGPLYNYADRDHCIQYMTAIPLIYGRLTAEDYTDEVAGNPDIDALRAKMYCEVDDTFTADYHHPDKRSIPNALLIELEDGTTLDEIVVEYPVGHKFRREEGIPLLMNKFKNLLNGHFKDNSKAENIYSVSTKDDFDNLDIDDYVDLYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKU9</accession>
    <name>Q6FKU9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">CAGL0L08470g</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKU9"/>
    <dbReference type="STRING" id="284593.Q6FKU9"/>
    <dbReference type="HOGENOM" id="CLU_1651928_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKU9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG62115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="160" mass="17892" checksum="92C37118414EC654" modified="2004-07-19" version="1">MYASQSCFDLFRCVASYDVETMENGLHITIHVRRKFNESFEFRLLSGIVAQQSHASGGVHCLNHLAVDLDVSAQEDQLLPAMSVVHFSPGIVPFHHTSLHITVESKDVVLVHICMYCRYIPFTHGNTIAMGCESSDPDITAADRDCHGKNSGDWRCGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL05</accession>
    <name>Q6FL05_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0L07172g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449089.1">
        <property type="nucleotide sequence ID" value="XM_449089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL05"/>
    <dbReference type="STRING" id="284593.Q6FL05"/>
    <dbReference type="CAZy" id="GT39">
        <property type="family name" value="Glycosyltransferase Family 39"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890834"/>
    <dbReference type="CGD" id="CAL0135908">
        <property type="gene designation" value="CAGL0L07172g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07172g"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FL05"/>
    <dbReference type="OMA" id="ENMFANN"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097584">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097585">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="469"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0135908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG62059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="777" mass="88573" checksum="C217B089EC541118" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL36</accession>
    <name>Q6FL36_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L06512g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62028.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL36"/>
    <dbReference type="KEGG" id="cgr:2890658"/>
    <dbReference type="CGD" id="CAL0134982">
        <property type="gene designation" value="CAGL0L06512g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06512g"/>
    <dbReference type="HOGENOM" id="CLU_2687575_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL36"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62028.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="74" mass="8613" checksum="B32DB35602C3A229" modified="2008-09-23" version="2">MMDNESKRRVDVTVQKRLRSILKQRFVSPTDAMLSPCSKRLNLYRSKVYAAKKTPRKLQFSESATKTPSKKHQS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLB8</accession>
    <name>MED4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MED4</name>
        <name type="ordered locus">CAGL0L04620g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448976.1">
        <property type="nucleotide sequence ID" value="XM_448976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLB8"/>
    <dbReference type="SMR" id="Q6FLB8"/>
    <dbReference type="FunCoup" id="Q6FLB8">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLB8"/>
    <dbReference type="EnsemblFungi" id="CAGL0L04620g-T">
        <property type="protein sequence ID" value="CAGL0L04620g-T-p1"/>
        <property type="gene ID" value="CAGL0L04620g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890646"/>
    <dbReference type="KEGG" id="cgr:2890646"/>
    <dbReference type="CGD" id="CAL0135512">
        <property type="gene designation" value="CAGL0L04620g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L04620g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04620g"/>
    <dbReference type="eggNOG" id="ENOG502RXM0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071875_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLB8"/>
    <dbReference type="OMA" id="PFQIHPN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000302074" description="Mediator of RNA polymerase II transcription subunit 4">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="264" mass="29618" checksum="2B1BEF009D37F2D3" modified="2004-07-19" version="1">MSLVAESNSGTISEQELDKVQLYSDLCLYEEALTKLVDSVDNFKPQLEIGKQLIEADKKLYSTLDLLPQYDSVFTRLRTLDDEISKVDQQTKNILSILNECHDDLNALPLLEEVEFEKKMILKQREKIKSNVLLEYATKLAKFTKIPPTFDKGTIGPNNFIWPAEDALRKGMLAMASLHGKELTKLPGQEDGEEDGSTANEDKNIVKDAEGAEGEIRQDDKKEDDSFVFGANANDAEGDEDKNAGEDEDEAMDSDLDLFNPDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLP3</accession>
    <name>Q6FLP3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Membrane protein PTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0L01881g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLP3"/>
    <dbReference type="FunCoup" id="Q6FLP3">
        <property type="interactions" value="627"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890673"/>
    <dbReference type="CGD" id="CAL0135584">
        <property type="gene designation" value="CAGL0L01881g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01881g"/>
    <dbReference type="eggNOG" id="KOG2568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024065_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FLP3"/>
    <dbReference type="OMA" id="TWGFYDF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274078" description="Membrane protein PTM1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="30"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="194"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0135584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="59661" checksum="5288339E7519E0BA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLQ3</accession>
    <name>Q6FLQ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Damage-regulated import facilitator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0L01573g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_448841.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cgr:2890884"/>
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        <property type="gene designation" value="CAGL0L01573g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01573g"/>
    <dbReference type="HOGENOM" id="CLU_1677633_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLQ3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0135340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="18050" checksum="2AFD57BA3E753E06" modified="2004-07-19" version="1">MQMYAPSSPVVANADVRLMMLLQQEQLKMQKRRMKRSHEMFEDNNYKRVKYGFHNSETRNTYPSIVPAIGTMNSTTNNNGNNINNISHDRMNLHNTVQTHGLRPEMSGLHNPDSDSEPYAEIEEYMVKGYCLDETVAGTQNITINEPSIMTDMMDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLU8</accession>
    <name>Q6FLU8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase II assembly factor RTP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAGL0L00517g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLU8"/>
    <dbReference type="FunCoup" id="Q6FLU8">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891109"/>
    <dbReference type="eggNOG" id="KOG4653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006300_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FLU8"/>
    <dbReference type="OMA" id="KRAYGAP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="5">
        <location>
            <begin position="747"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="4">
        <location>
            <begin position="964"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG61766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1000" mass="115142" checksum="BE7F978F0A520468" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM47</accession>
    <name>Q6FM47_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0K11066g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448697.1">
        <property type="nucleotide sequence ID" value="XM_448697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM47"/>
    <dbReference type="FunCoup" id="Q6FM47">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM47"/>
    <dbReference type="KEGG" id="cgr:2890085"/>
    <dbReference type="CGD" id="CAL0134037">
        <property type="gene designation" value="CAGL0K11066g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11066g"/>
    <dbReference type="eggNOG" id="KOG4750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_3_4_1"/>
    <dbReference type="InParanoid" id="Q6FM47"/>
    <dbReference type="OMA" id="NQGCTFM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0134037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20576" checksum="EC9F160323757483" modified="2004-07-19" version="1">MNTQDFINQLNTGEPVFAGTETYKFMHGVSQDALKITMEMNNKYHTPEELLELFSQLIGKQVDPTFCLFPPFYTDCGKNITVGKRVFINSGCRFQDQGGVTIGDDCLIGHNAVLATLNHGMSPADRKNLYPAPIRIGNNVWLGANVTVLPGVTIGDNAVVAAGAVVTKDVPENMIVAGVPAKILKSIHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM54</accession>
    <name>Q6FM54_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0K10912g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM54"/>
    <dbReference type="FunCoup" id="Q6FM54">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM54"/>
    <dbReference type="KEGG" id="cgr:2890078"/>
    <dbReference type="CGD" id="CAL0134505">
        <property type="gene designation" value="CAGL0K10912g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10912g"/>
    <dbReference type="eggNOG" id="KOG3278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090033_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM54"/>
    <dbReference type="OMA" id="IKMTAKV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0134505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="267" mass="31171" checksum="6CEA7171C30D45A9" modified="2004-07-19" version="1">MINLLVGPLLGSLKLSVPFSRNFSVTANAMRRWKLVECRRVAKQPEYKVGDVRPNYVPKERKEFPDYKYGEALVFKQSNKGLYGGSFVKYGNKISESKHKTRRTWHPNVIKKSLWSETLNRSINIKMTAKVLRTIIKEGGIDNYLIKDKSARIKELGPTGWKLRYRIMQRKEQLNNPPHHDKPVVKLADGTEAKVLYEQEIDGESYRIKVGRRKLMTYLYPLEKLEHKADGKPLNHKEFIDKFGDLKAEQIIQRLHKYNFDLKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM77</accession>
    <name>Q6FM77_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K10296g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM77"/>
    <dbReference type="FunCoup" id="Q6FM77">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM77"/>
    <dbReference type="KEGG" id="cgr:2890117"/>
    <dbReference type="CGD" id="CAL0134649">
        <property type="gene designation" value="CAGL0K10296g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10296g"/>
    <dbReference type="eggNOG" id="KOG3035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051989_0_3_1"/>
    <dbReference type="InParanoid" id="Q6FM77"/>
    <dbReference type="OMA" id="VIWPKVI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="248" mass="27843" checksum="5F4D77F6B14FE129" modified="2004-07-19" version="1">MLQVKKLLLFGDSITQFSCGRCESVEEAGRIDGFSLGSGLGAVYNRKLDVVTRGFSGYNTRWCLPVLDAVLDAELQGQNEVALSVIFFGSNDSVSDGPQRVPLEEYCQNIVKMVGKMKAAKIKTVLVTPARVDKQQWSHHFAEDAKVGYVRSDALYKEYRDQLLKIGEQEGIPVVDLYTEFGKHDVSSLLTDGIHFSSEGYRVFFLALMKTIRENLPELAPENLPWHLPYWRDVTEDPTSVIAALNKY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM91</accession>
    <name>TVP23_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TVP23</name>
        <name type="ordered locus">CAGL0K09988g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448653.1">
        <property type="nucleotide sequence ID" value="XM_448653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM91"/>
    <dbReference type="FunCoup" id="Q6FM91">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM91"/>
    <dbReference type="GlyCosmos" id="Q6FM91">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0K09988g-T">
        <property type="protein sequence ID" value="CAGL0K09988g-T-p1"/>
        <property type="gene ID" value="CAGL0K09988g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890209"/>
    <dbReference type="KEGG" id="cgr:2890209"/>
    <dbReference type="CGD" id="CAL0134729">
        <property type="gene designation" value="CAGL0K09988g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K09988g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09988g"/>
    <dbReference type="eggNOG" id="KOG3195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1190470_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM91"/>
    <dbReference type="OMA" id="KMIWWID"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000343043" description="Golgi apparatus membrane protein TVP23">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="196" mass="22505" checksum="378B1642F46FEE6B" modified="2004-07-19" version="1">MDHVRNFYDTILRSSHPLLMAFHLAGKAAPLAFYIAGFLFPSFTALFITIVLLLAADFYFTKNISGRRLVQLRWWYDSSATSTETFTFESHKQYTAGPPINPIDSKLFWWSMYLTPAIWFVLGILAILRLKLITFILIAVATCMTGWNTYGFRCCDRWNPNNSQSTEPFFQLPSIPGLDNITRLARFQSFFQSAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMC2</accession>
    <name>Q6FMC2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K09262g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMC2"/>
    <dbReference type="FunCoup" id="Q6FMC2">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMC2"/>
    <dbReference type="KEGG" id="cgr:2890254"/>
    <dbReference type="CGD" id="CAL0134199">
        <property type="gene designation" value="CAGL0K09262g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09262g"/>
    <dbReference type="eggNOG" id="KOG3299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045276_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FMC2"/>
    <dbReference type="OMA" id="HLMQVMD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031333">
        <property type="term" value="P:negative regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23822">
        <property type="entry name" value="RWD_ScYIH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.30:FF:000002">
        <property type="entry name" value="Protein IMPACT homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RWD" evidence="7">
        <location>
            <begin position="7"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="259" mass="29233" checksum="B9218907217FA293" modified="2004-07-19" version="1">MDELVVEELESLEAIYPDLLKRDDAENIFAMKVPQHEKFTVKISLPDKYPATEPPHVLEVSVAQGDYDSKYLTTLFQEVMDSMFHQGSVCLFDFFTELDGVLYDDEEESSMDAAEVVDNSALVPVDPFEGWTASDPISDRGSTFMAFAAHVNSEEEAFQMLDHLKTDSKMRRANHAMCAWRIKKQTDSNDIIYQDCDDDGETAAGSRMLHLVTIMDVWNVIVVVARWFGGVHIGPDRFKHINSTAREAILRAGFTPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMD9</accession>
    <name>Q6FMD9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K08844g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMD9"/>
    <dbReference type="FunCoup" id="Q6FMD9">
        <property type="interactions" value="728"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMD9"/>
    <dbReference type="KEGG" id="cgr:2890287"/>
    <dbReference type="CGD" id="CAL0134513">
        <property type="gene designation" value="CAGL0K08844g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08844g"/>
    <dbReference type="eggNOG" id="KOG3888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021859_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FMD9"/>
    <dbReference type="OMA" id="VHITWPN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="191"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="508" mass="59292" checksum="3AB2341145593320" modified="2004-07-19" version="1">MIRSHMRRFRHNAATSLLRHTRLYSQASGKILDASFTDESTTVTFLHESMVQPNDSVPTSLDATPDTQDKIRPFTVCFNNIFLRDASKSPKTVDPVSGQRLVTTAELLDEHNGRRATVPRSVNISEDGKRLVVDWSDGDSYAYDLDFFFKYKGSSFLTKSIRNQMSKHKRVFWNRDLLNSKIDKNRDGSFFSFDQVMNDDKLLYRTLVNLQQFGITFISGMPTIRDETDANDANIYMVRNLCERIGPLRKTFYGEVFDITNQNLKDYDQDLPPPHDYNIPFENIASPLHMDLQFLENVPGFKILHALKNESENDTNIFVDSLYAARNIRETDNEAYEALQHVPINYTFKNKNKRYYQSKPLVEEYESNEHNTLIGNYEYLVKCVNYSPPFQAPFTYGIYNKLTNVPKIEGIEDPLTTSPGKVTERLVFRDFLRGLQQFEKMVYDHENQLRINLPENTAVIYNNRRILHTRTNHNTRQSDLVWFKSCYFDLDTFKSKLKFLEEAFEKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FML3</accession>
    <name>Q6FML3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vacuolar cation-chloride cotransporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0K07073g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FML3"/>
    <dbReference type="FunCoup" id="Q6FML3">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FML3"/>
    <dbReference type="KEGG" id="cgr:2890390"/>
    <dbReference type="CGD" id="CAL0134669">
        <property type="gene designation" value="CAGL0K07073g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07073g"/>
    <dbReference type="eggNOG" id="KOG1288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001883_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FML3"/>
    <dbReference type="OMA" id="NIKYWRP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="73"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="562"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="928"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="933"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1014"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0134669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1120" mass="124365" checksum="DEA41BD0DB632B9B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMM3</accession>
    <name>Q6FMM3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxalate--CoA ligase</fullName>
            <ecNumber evidence="5">6.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Acyl-activating enzyme 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Oxalyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0K06853g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMM3"/>
    <dbReference type="FunCoup" id="Q6FMM3">
        <property type="interactions" value="665"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMM3"/>
    <dbReference type="KEGG" id="cgr:2890409"/>
    <dbReference type="CGD" id="CAL0134807">
        <property type="gene designation" value="CAGL0K06853g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06853g"/>
    <dbReference type="eggNOG" id="KOG1176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_1"/>
    <dbReference type="InParanoid" id="Q6FMM3"/>
    <dbReference type="OMA" id="TFRGYYR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050203">
        <property type="term" value="F:oxalate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033611">
        <property type="term" value="P:oxalate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05926">
        <property type="entry name" value="FACL_fum10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000039">
        <property type="entry name" value="Peroxisomal-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045310">
        <property type="entry name" value="Pcs60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="10">
        <location>
            <begin position="445"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00078960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0134807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="537" mass="60001" checksum="9B557673B1A64407" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMQ5</accession>
    <name>Q6FMQ5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Extracellular mutant protein 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0K06127g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMQ5"/>
    <dbReference type="FunCoup" id="Q6FMQ5">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890454"/>
    <dbReference type="CGD" id="CAL0133803">
        <property type="gene designation" value="CAGL0K06127g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06127g"/>
    <dbReference type="eggNOG" id="ENOG502S4IU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874350_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMQ5"/>
    <dbReference type="OMA" id="HISIMGR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029178">
        <property type="entry name" value="Ecm11_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15463">
        <property type="entry name" value="ECM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Extracellular mutant protein 11 C-terminal" evidence="3">
        <location>
            <begin position="195"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0133803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="318" mass="35889" checksum="6E54765AA2E0E2B2" modified="2004-07-19" version="1">MCNCTKIDKTQALENLWSWCVINYISSAACVLVSVSSMFIKSEAGAIENNDKKRYKVNKEKHDTHRKKKDKSILESFLLVPGQLDGASDPAKFVPGLGLKTPIKDEGNISLPSINLPPSEMRSRWRSSGSLFGPQEVDNNLLPKVNKSPGVKTPTSTKQRPHSTQPEETKPADTLVTPTSPLVEERQNNADSLKPAEDPGPFKKQTRLLYEVQNDMTIDDDNMTEIFPGLEKEEEKTYCRQSSLWSLDQWIEEGENILRAHQEIFIKIIKKRIELSYNFNSLITVLIDRAEALCKHGNVIDSKLEKVKKLGNEILNIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMU7</accession>
    <name>SSU72_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName>CTD phosphatase SSU72</shortName>
            <ecNumber>3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Suppressor of SUA7 protein 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SSU72</name>
        <name type="ordered locus">CAGL0K05071g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448447.1">
        <property type="nucleotide sequence ID" value="XM_448447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMU7"/>
    <dbReference type="SMR" id="Q6FMU7"/>
    <dbReference type="FunCoup" id="Q6FMU7">
        <property type="interactions" value="1025"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMU7"/>
    <dbReference type="EnsemblFungi" id="CAGL0K05071g-T">
        <property type="protein sequence ID" value="CAGL0K05071g-T-p1"/>
        <property type="gene ID" value="CAGL0K05071g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890504"/>
    <dbReference type="KEGG" id="cgr:2890504"/>
    <dbReference type="CGD" id="CAL0134219">
        <property type="gene designation" value="CAGL0K05071g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K05071g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05071g"/>
    <dbReference type="eggNOG" id="KOG2424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062463_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FMU7"/>
    <dbReference type="OMA" id="TQPNVYQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180007">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032215">
        <property type="term" value="P:positive regulation of telomere maintenance via semi-conservative replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090052">
        <property type="term" value="P:regulation of pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902801">
        <property type="term" value="P:regulation of siRNA-independent facultative heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009302">
        <property type="term" value="P:sno(s)RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030846">
        <property type="term" value="P:termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0904">Protein phosphatase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000255605" description="RNA polymerase II subunit A C-terminal domain phosphatase SSU72">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="204" mass="23379" checksum="4660A18012F677A7" modified="2004-07-19" version="1">MDQKQALKFCTVCASNNNRSMESHRILQEAGYEVSSYGTGSAVRLPGLSFDKPNVYPFGTPYNDIYNDLLSQSAERYKANGLLQMLDRNRRLKKAPEKWQEGTKTFDFVFTCEERCFDAVCEDLMNRGGRLNKIVHVINIDIRDDNENAKIGGRAILELANMLNEKVSECEQNDTLFEDCILDILTKWQEAHPQLPCLYAPSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN80</accession>
    <name>Q6FN80_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Magnesium-dependent phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0K02035g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448314.1">
        <property type="nucleotide sequence ID" value="XM_448314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN80"/>
    <dbReference type="FunCoup" id="Q6FN80">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN80"/>
    <dbReference type="KEGG" id="cgr:2890332"/>
    <dbReference type="CGD" id="CAL0134191">
        <property type="gene designation" value="CAGL0K02035g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02035g"/>
    <dbReference type="eggNOG" id="KOG4549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071162_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FN80"/>
    <dbReference type="OMA" id="GVWAWRK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030946">
        <property type="term" value="F:protein tyrosine phosphatase activity, metal-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0134191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20864" checksum="627B42708DF73A0F" modified="2004-07-19" version="1">MSYPEVAVFDLDYTVWPCYCDSHVFSPFKPVVNDNGEVHTLVDRHGFEVTFFPDIPRIFTDLKDHGVKLISASRTWAPEVAQELLKGFKIRYHGKLVTLHEMFDSLKWGERSKVGHIQDGMKEIYGSTELKKYRICLFDDESRNRDVERHGVKFIYIRNPEKGPTWSLYQKYLNGELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FND8</accession>
    <name>Q6FND8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase SLI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0K00737g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FND8"/>
    <dbReference type="FunCoup" id="Q6FND8">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FND8"/>
    <dbReference type="KEGG" id="cgr:2890517"/>
    <dbReference type="CGD" id="CAL0134251">
        <property type="gene designation" value="CAGL0K00737g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00737g"/>
    <dbReference type="eggNOG" id="ENOG502RC91">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_599872_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FND8"/>
    <dbReference type="OMA" id="TEINHIF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0134251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="52246" checksum="848669E611CA0522" modified="2004-07-19" version="1">MVRHLGGIEQYFYQRSSLNLHSCFSVGVELNSLPNRSDFICALRRVVNSHFQLYCNAYKSNNEVVVNPIGEPIKFDDVVDYMDWDTYGEEEINSVFRKYNFEYGVDKPLWKVIVVPKANKMIFATDHLFFDGIATVLFWTELLKSLEELKQDNDLDVDEIIYRPGGSTDSIDQCHPYEKLPIPFSWKVKRPIVKALFTIAPGAVVSQDASIIQFDEYKIPEDYLKKNSNDDGCYQIKNTNRQISLKMSSNKLKVIMKDCKQHHVSFTAYLTAVLYLALGKIPKEKYSGSTIKYEVPMNTRNRISNSGEYSNSYGTFVAGGEFIETLDFERDEWELAQSIHKKIVEKSTTGVMDAINEARLLELVDAKKFMKMKFETTTGPSSTFEVTNLGFQNFSQNEHSKYTVTDAFFNEPQLFTNLITYSVISTPSGGLNCSMAYPEKLDSILCNSVAFLKNKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNE5</accession>
    <name>Q6FNE5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0K00583g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNE5"/>
    <dbReference type="STRING" id="284593.Q6FNE5"/>
    <dbReference type="KEGG" id="cgr:2890230"/>
    <dbReference type="CGD" id="CAL0133795">
        <property type="gene designation" value="CAGL0K00583g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00583g"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_6_1_1"/>
    <dbReference type="InParanoid" id="Q6FNE5"/>
    <dbReference type="OMA" id="WLGTMFM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0133795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG61210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="298" mass="35019" checksum="C4E8C539EFC6688F" modified="2004-07-19" version="1">MLQDYTPTVDRPFFNIYLWSHFNDAASYLTNGRFVPDEFQFFPGGPPLSKFSHVLVGIATYYLLVFGGRYMLRNTRPFKLNTLFQCHNLFLTSFSFLLLTLMVEQLVPLLIRHGLYDTLCSKYAWTQPLMTLYYLNYLTKFVEFIDTLFLVVKHKNLTFLHTYHHGATALLCYIQLVGHTTIAWVPITLNLGVHVVMYWYYFLAARGIRVWWKEWVTRFQIIQFILDVGFIYFAAYQKTAYRFYPSWPHCGDCVGTLTSNYSGCAIISSYLFLFIAFYIEVYKRSGTKKPVTTNKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNY9</accession>
    <name>Q6FNY9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J07986g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNY9"/>
    <dbReference type="FunCoup" id="Q6FNY9">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNY9"/>
    <dbReference type="KEGG" id="cgr:2889862"/>
    <dbReference type="CGD" id="CAL0132996">
        <property type="gene designation" value="CAGL0J07986g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07986g"/>
    <dbReference type="eggNOG" id="KOG4595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136375_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNY9"/>
    <dbReference type="OMA" id="VGFQRFV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0132996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="162" mass="18828" checksum="65B3B187FDB985F3" modified="2004-07-19" version="1">MNTDELLFLEEQFYQEGYEEGRNENLKNNLIEGKEFGLQVGFQRFVLLGQMVGMCDVLDSLQLKNNSLFKNIANVRELISSIELNNKEENVESLEKTLVKLKNKFRLILLSFQREFKHNDRKPINFDNFEDLSRAIAGEIKGFVEDEDATDAKTTQDQAQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP53</accession>
    <name>Q6FP53_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural protein MDM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0J06556g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP53"/>
    <dbReference type="FunCoup" id="Q6FP53">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP53"/>
    <dbReference type="KEGG" id="cgr:2889543"/>
    <dbReference type="CGD" id="CAL0133586">
        <property type="gene designation" value="CAGL0J06556g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06556g"/>
    <dbReference type="eggNOG" id="KOG2101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002131_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FP53"/>
    <dbReference type="OMA" id="AMYVVEV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="86"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="734"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0133586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1078" mass="125107" checksum="28F91C8189019840" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPA6</accession>
    <name>Q6FPA6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein USE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0J05368g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPA6"/>
    <dbReference type="FunCoup" id="Q6FPA6">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPA6"/>
    <dbReference type="KEGG" id="cgr:2889477"/>
    <dbReference type="CGD" id="CAL0133110">
        <property type="gene designation" value="CAGL0J05368g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05368g"/>
    <dbReference type="eggNOG" id="KOG2678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093583_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPA6"/>
    <dbReference type="OMA" id="GANAFND"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15860">
        <property type="entry name" value="SNARE_USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0133110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25362" checksum="84B816726E883B4E" modified="2004-07-19" version="1">MSSTLIDFLVTSKEACNNKCRREAAIRDGTVEQYEQQYSKTSFEYDSKCYSLLKDMEKEYNKYESSIKHRRYSEDFDGTHGDEDDSKELKINTEDESVAELRKRLLGRLSDKAEQDAGQSVETQIQNHEDMQQNLYEDMSKLVGSLKQGAVAFQNALEEDQKVLGAAEIGIQVASRGIVDISGKLKTYDKAKLGYLFYILTFLFMFIGLCVTFIIIKIFPAM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2025-06-18" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPD4</accession>
    <name>ATG17_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATG17</name>
        <name type="ordered locus">CAGL0J04686g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447910.1">
        <property type="nucleotide sequence ID" value="XM_447910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPD4"/>
    <dbReference type="SMR" id="Q6FPD4"/>
    <dbReference type="FunCoup" id="Q6FPD4">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPD4"/>
    <dbReference type="EnsemblFungi" id="CAGL0J04686g-T">
        <property type="protein sequence ID" value="CAGL0J04686g-T-p1"/>
        <property type="gene ID" value="CAGL0J04686g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889451"/>
    <dbReference type="KEGG" id="cgr:2889451"/>
    <dbReference type="CGD" id="CAL0133050">
        <property type="gene designation" value="ATG17"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04686g"/>
    <dbReference type="eggNOG" id="ENOG502QQDW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051526_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPD4"/>
    <dbReference type="OMA" id="PENIWPN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120095">
        <property type="term" value="C:vacuole-isolation membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045772">
        <property type="term" value="P:positive regulation of autophagosome size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000124558" description="Autophagy-related protein 17">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="409" mass="47978" checksum="3C2F69D2533847A1" modified="2004-07-19" version="1">MPESLAERARSTLLKAQVLCREVESRIAEVKDRLSQWEKNRHTLRFLVSCLEHQLGFLEQCALRQGIGRALIETEWSQVVLVDLVNEMKLWYDKIQLRLERLDQVENILVADNKHLSHYISQEQALVLKKRLDEVPIIRPQIENIQTQYDTMCKRVRQKLINKRLTEIKTIFDSQFGDELTETAELTEVKPRDLDSIELELVDYINSLTDHFDKCQALEKGLFNDSNEYDELLKIVSADDSQLDDIMKHLLNTIDSTNHQIDKVYEILDIKTKQKTILHGKINELIANCTKYSEYLAIFKGIATSIEKFKEGCMQDIQLTKELYKFYDEFENSYNKLLQEVQRRRALSQKMLGIIKNCENELKTLHDEDQKLRTHFLSENGAFLPETIWPGEIDDLSPLYALDYHIKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPE4</accession>
    <name>Q6FPE4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein PUN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0J04466g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPE4"/>
    <dbReference type="FunCoup" id="Q6FPE4">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889638"/>
    <dbReference type="CGD" id="CAL0132886">
        <property type="gene designation" value="CAGL0J04466g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04466g"/>
    <dbReference type="eggNOG" id="ENOG502S4UA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1147965_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPE4"/>
    <dbReference type="OMA" id="MNWAFVI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273394" description="Protein PUN1" evidence="6">
        <location>
            <begin position="22"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0132886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29311" checksum="AC18CF38DF4A5BF0" modified="2004-07-19" version="1">MRNFVALILALFFALASLVLACIACAGSTKNYYPINQIFCAQLDLSNLDIATVIPAASSFSISDLGLPKFINIGLWSYCVASSSTDVTSCTSPNGIQTFNLKNLLKDNIENNQVLQLVDDVAKIVLPQQLQDKLVYYNNLVKCMFITLIIGIVLTFLNLVINVLRWFLHFSFVNFVGGFVCFLSFASLLISVGTNMGTYIYIRHILNKNYSDYGIHLSLGRKFLALLWAAVVAALLNLFCWMTVRQRKKVVYVHQPYNDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPI3</accession>
    <name>Q6FPI3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0J03608g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPI3"/>
    <dbReference type="FunCoup" id="Q6FPI3">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPI3"/>
    <dbReference type="KEGG" id="cgr:2889681"/>
    <dbReference type="CGD" id="CAL0133100">
        <property type="gene designation" value="CAGL0J03608g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03608g"/>
    <dbReference type="eggNOG" id="KOG2294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020432_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPI3"/>
    <dbReference type="OMA" id="DVYSVWK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903108">
        <property type="term" value="P:regulation of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051300">
        <property type="term" value="P:spindle pole body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000260">
        <property type="entry name" value="Forkhead transcription factor (Sep1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="112"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="112"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="35"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0133100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="548" mass="61014" checksum="9279E9ADA3893730" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ66</accession>
    <name>Q6FQ66_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LSO1/LSO2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I08767g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ66"/>
    <dbReference type="FunCoup" id="Q6FQ66">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ66"/>
    <dbReference type="KEGG" id="cgr:2888998"/>
    <dbReference type="CGD" id="CAL0132080">
        <property type="gene designation" value="CAGL0I08767g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08767g"/>
    <dbReference type="eggNOG" id="KOG3223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186256_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ66"/>
    <dbReference type="OMA" id="KWDQGSR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030371">
        <property type="term" value="F:translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031670">
        <property type="term" value="P:cellular response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141014">
        <property type="term" value="P:ribosome hibernation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054413">
        <property type="entry name" value="LSO1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22048">
        <property type="entry name" value="LSO1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LSO1/LSO2" evidence="2">
        <location>
            <begin position="10"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="90" mass="10144" checksum="EF1FF971D8B59494" modified="2004-07-19" version="1">MGKRFSESAAKKAAGQARKREQAYHKHQAELAAQEAEEAAKWEQGSRKENPKKLLEEQKKQEKLRAKKEREALLAEEEASLGKGGKGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQB5</accession>
    <name>Q6FQB5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinol 3-O-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone 3-O-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">3-demethylubiquinone-6 3-O-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Hexaprenyldihydroxybenzoate methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <shortName evidence="5">DHHB methyltransferase</shortName>
            <shortName evidence="5">DHHB-MT</shortName>
            <shortName evidence="5">DHHB-MTase</shortName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
            <ecNumber evidence="5">2.1.1.114</ecNumber>
            <ecNumber evidence="5">2.1.1.64</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">COQ3</name>
        <name evidence="6 7" type="ordered locus">CAGL0I07601g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol into ubiquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-methionine = a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Mitochondrion inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EC" id="2.1.1.114" evidence="5"/>
    <dbReference type="EC" id="2.1.1.64" evidence="5"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447579.1">
        <property type="nucleotide sequence ID" value="XM_447579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQB5"/>
    <dbReference type="FunCoup" id="Q6FQB5">
        <property type="interactions" value="354"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQB5"/>
    <dbReference type="GeneID" id="2888978"/>
    <dbReference type="KEGG" id="cgr:2888978"/>
    <dbReference type="CGD" id="CAL0132450">
        <property type="gene designation" value="CAGL0I07601g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07601g"/>
    <dbReference type="eggNOG" id="KOG1270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042432_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FQB5"/>
    <dbReference type="OMA" id="LASRWWD"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0132450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="299" mass="34921" checksum="11FA546DE60497C3" modified="2004-07-19" version="1">MMNRFTSRISRLQLGRVAKRLKSTEASQDEIHHFQELAPTWWDPHGPQRILHLMNNARLDFIQRTLRSCVKVDNPDIFIPGFDHTSFLPRYVSNNIERELTEEINDQLVHKQYSVLDIGCGGGILGESMARLPFVKRVTGIDLTPEVIEVAKQHSLQDPAILDKLDYKLMPLEKVQEKFDIVTCFEMLEHVDYPSEILKHAWNRLHQGGILYLSTINRDPISWFTTIFMGEDVLKIVPKGTHHLNKYINSREVKNWFKKNHAHRHEILDCKGTMYLPLKGWVEHDCQDIGNYFMAIRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQI4</accession>
    <name>Q6FQI4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIOREX complex component 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0I05984g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQI4"/>
    <dbReference type="FunCoup" id="Q6FQI4">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889228"/>
    <dbReference type="CGD" id="CAL0132646">
        <property type="gene designation" value="CAGL0I05984g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05984g"/>
    <dbReference type="eggNOG" id="ENOG502RYWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061864_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQI4"/>
    <dbReference type="OMA" id="KRINTHY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="46396" checksum="6C9C5FC8050555EC" modified="2004-07-19" version="1">MAGGAQRRFFSQIVRLLKSKSKSNHKVLVDDAQLKETLKYIIEDKRVLPGGLRSLLPGSLEGTDEDVQKHSERLASLLNATLPTVSDKKRQVESHYDLLFGQLKNMVEESLHDTGKSSHNRTLSAHNQMNKSETLFNRLILLLLTGGDTVSTKSIAELILSPDFKEYSKVWDNIKLFPESKRLDISILLYYSSKNKNIMDAYEEEWISRYHDLNVITQRLFWRFMDPLGKVSECCERIRYWQPRDTIVMYQSLYSTAHFLPTEFHYVDNLQLSNNQIFFIKALRFLAQYRQRSLLQVPREPVNATTKQTKTAKNWASDIVKLSIQNKLSLDKRLKDDSEMVPVYSYRFLRALDVNLQEICGLDSLNDENLAHLQADLNTLLTSLHEEEQTLKSHMSLFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQV7</accession>
    <name>Q6FQV7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="12">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RIP1</name>
        <name evidence="15 16" type="ordered locus">CAGL0I03190g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="12">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="12"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447387.1">
        <property type="nucleotide sequence ID" value="XM_447387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQV7"/>
    <dbReference type="FunCoup" id="Q6FQV7">
        <property type="interactions" value="858"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQV7"/>
    <dbReference type="GeneID" id="2889168"/>
    <dbReference type="KEGG" id="cgr:2889168"/>
    <dbReference type="CGD" id="CAL0132258">
        <property type="gene designation" value="RIP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03190g"/>
    <dbReference type="eggNOG" id="KOG1671">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FQV7"/>
    <dbReference type="OMA" id="KRTWLIA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="118"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0132258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG60324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="213" mass="23187" checksum="0E3CB62FA1674331" modified="2004-07-19" version="1">MSMLLRSSIKNGCRLNAARMFSTSLVANKSTYRTPNFDDVLRDDQNSDKSRSYAYFMVGSLGLLSSVGAKSTVETFVSSMSASADVLAMAKVEVNLAAIPEGKNVVVKWQGKPVFIRHRTAHEIDEANAVDMSVLKDPQTDADRVKDPKWLVMLGICTHLGCVPIGEAGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEVPAYEFDGEKLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQW4</accession>
    <name>Q6FQW4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ERG24</name>
        <name evidence="17 18" type="ordered locus">CAGL0I02970g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP(+) = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:18364"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.70"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:18563"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447380.1">
        <property type="nucleotide sequence ID" value="XM_447380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQW4"/>
    <dbReference type="FunCoup" id="Q6FQW4">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQW4"/>
    <dbReference type="GeneID" id="2889143"/>
    <dbReference type="KEGG" id="cgr:2889143"/>
    <dbReference type="CGD" id="CAL0132418">
        <property type="gene designation" value="ERG24"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02970g"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_0_3_1"/>
    <dbReference type="InParanoid" id="Q6FQW4"/>
    <dbReference type="OMA" id="EWCELRP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000009">
        <property type="entry name" value="C-14 sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="8 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9 16" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0132418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG60317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="437" mass="50499" checksum="D71BB1712B78E391" modified="2004-07-19" version="1">MLNPKTKHFEFNGVVGAVAISVGLPIFTVFLNQMVRPEYYIEGWFSNFNLDKVFSGLHSLDYYFVDRWDLWVYYLTWYFVLAFLDVVLPGRVMEGVELRDGTKLKYKINGVALSTFMVVVVAMRWQLTQGRVPELQFLYKNHVDICVIAILFSALLATYCYIASFVPLLINSPNGVGTNEKILALGGNSGNPIYDWFIGRELNPRIGPLDLKMFSELRPGMLLWLLINLSCLHHHYLRTGTFNDALVLVNLLQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLALVPFTYSLQARYLSVSPIELGLPRVIFIVGVMALGFYIFRSANKQKSDFRQGNLPHLKSIQTKRGTKLLADGWWAKSQHINYFGDWLISLSWCLTTWFQTPLTYYYSLYFATLLLHRQQRDEHKCREKYGENWAEYEKQVPYKIIPYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQX2</accession>
    <name>Q6FQX2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0I02794g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQX2"/>
    <dbReference type="FunCoup" id="Q6FQX2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889026"/>
    <dbReference type="CGD" id="CAL0132452">
        <property type="gene designation" value="CAGL0I02794g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02794g"/>
    <dbReference type="eggNOG" id="ENOG502S6F5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1034658_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQX2"/>
    <dbReference type="OMA" id="HFARINY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="252" mass="29925" checksum="E2FA23EB8A854994" modified="2004-07-19" version="1">MRFTLHLYARPSSILVSCKKAFKKSAQKDIGTVFNYYYNMQVKKFGNTTLMRFNNSFKRYIRSEWDNLSATKKRLYYAMFFEQHNLSPSELTSYELARCLEIEKPAASEYLMFRNRFKSKFDRLWRQNSEVNMKLIFQSGSIANNYHEFSSCRAKRSIQHIDPNRDYILRFKEMCKECRRIWNTKVGEEEKKTIHEHWLNAQQEFKNTLDIEIEVIKLNLEKLANAKRVGNSQAVSDHGNAMTLLMMKTSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQY2</accession>
    <name>Q6FQY2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thiol-specific monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0I02530g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQY2"/>
    <dbReference type="FunCoup" id="Q6FQY2">
        <property type="interactions" value="681"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQY2"/>
    <dbReference type="KEGG" id="cgr:2889386"/>
    <dbReference type="CGD" id="CAL0129787">
        <property type="gene designation" value="CAGL0I02530g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02530g"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006909_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FQY2"/>
    <dbReference type="OMA" id="WFGQSHT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0129787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="49480" checksum="72E9C785826B86C6" modified="2004-07-19" version="1">MTKNQKTVCIIGGGPGGLAAARVLSKDFPEAKITLIEKEEDVGGVWYYPENNKEGRVMYDYLETNLSKDLMKFSGFPFKDDVPFYPRKNQVFDYLKEYYQTYIKNHSNVDIELETEVINVDKKSDKWIVTTKHANSETVRELDFVIVSNGHFKEPKYPKDVFGLDSWLSNGKAFHSKDFYNCEFAKDKKIIVVGNGSSGSDIANQISTVAAKVYVSVTNVEDFKDKNNDPEFIVEYIPKIKSVGGDDSSVKLEDGRVIENIDYIIYATGYLYSLPFFASHISEKLLKQDQSGITNLWEQCVYKEDPTLGFLLLSIMVVPFPLAESQSTILSQVFQGNIDIATVTPSRDEVEHEKNYGHNFPKLSDIDFYRELQDILDKHGSNTFKPVVWDEVYEKKRKESAEVKQQRNEYLAKHAQKLHKENRPYYLPDNF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR40</accession>
    <name>YPT35_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">YPT35</name>
        <name type="ordered locus">CAGL0I01144g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The PX domain binds phosphatidylinositol 3-phosphate (PtdIns(3)P) which is necessary for peripheral membrane localization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447304.1">
        <property type="nucleotide sequence ID" value="XM_447304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR40"/>
    <dbReference type="SMR" id="Q6FR40"/>
    <dbReference type="FunCoup" id="Q6FR40">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0I01144g-T">
        <property type="protein sequence ID" value="CAGL0I01144g-T-p1"/>
        <property type="gene ID" value="CAGL0I01144g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889335"/>
    <dbReference type="KEGG" id="cgr:2889335"/>
    <dbReference type="CGD" id="CAL0132214">
        <property type="gene designation" value="CAGL0I01144g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01144g"/>
    <dbReference type="eggNOG" id="ENOG502S40T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1475537_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR40"/>
    <dbReference type="OMA" id="FAVWKIT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036010">
        <property type="term" value="P:protein localization to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000333493" description="Endosomal/vacuolar adapter protein YPT35">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="40"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="173" mass="20009" checksum="9F44137EF712EDEF" modified="2004-07-19" version="1">MADKVAVLDPEPITLLDTEDEPGISQSRRSSIANSNFYIERAFVTNCTIISGERSTPKFAVWKVTAVLHPLNPNSSGSYRIHTYKRYSDFVEFRNALLDRVRTKRPASVSEIPELPPPVKWYYSWKYNEINLNKEWLANRRKGLELFINQVLLNGNIVDIAKDLVIQFLRPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR91</accession>
    <name>Q6FR91_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAGL0H10472g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR91"/>
    <dbReference type="FunCoup" id="Q6FR91">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR91"/>
    <dbReference type="KEGG" id="cgr:2888628"/>
    <dbReference type="eggNOG" id="KOG4852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044104_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR91"/>
    <dbReference type="OMA" id="EYPRNEF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="248" mass="29290" checksum="ADF927811740C20E" modified="2004-07-19" version="1">MVNKYLTLNKDSENSRKKRKPSRKHFRGAAAEVKSLPSQDYVYDVYHLEQVPEDEYNKYEGSKVGFIKIIDVYGDLLPDELTDSDEQFLSDEEDSNDENYYRNDYPEDEDDDRSILFGSEGEEMAELETEFLANHDVDEFERPEMTDSADVIRPREDYDPKIATYDDVFSKLQGSSNILRSINDANFIDLDRDFEEEEGSDGEFMYNEEQEDKDEFPRNEFFPTDKDDPVAIHRDRIFHRLQKMIEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRA8</accession>
    <name>Q6FRA8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PRP1 splicing factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0H10098g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRA8"/>
    <dbReference type="FunCoup" id="Q6FRA8">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRA8"/>
    <dbReference type="KEGG" id="cgr:2888619"/>
    <dbReference type="CGD" id="CAL0131928">
        <property type="gene designation" value="CAGL0H10098g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10098g"/>
    <dbReference type="eggNOG" id="KOG0495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007010_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRA8"/>
    <dbReference type="OMA" id="DGWAWYY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071001">
        <property type="term" value="C:U4/U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="8">
        <location>
            <begin position="45"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="766"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0131928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="861" mass="100354" checksum="71495D73E7487B29" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRC1</accession>
    <name>FMP52_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein FMP52, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FMP52</name>
        <name type="ordered locus">CAGL0H09768g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447223.1">
        <property type="nucleotide sequence ID" value="XM_447223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRC1"/>
    <dbReference type="SMR" id="Q6FRC1"/>
    <dbReference type="FunCoup" id="Q6FRC1">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRC1"/>
    <dbReference type="EnsemblFungi" id="CAGL0H09768g-T">
        <property type="protein sequence ID" value="CAGL0H09768g-T-p1"/>
        <property type="gene ID" value="CAGL0H09768g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888564"/>
    <dbReference type="KEGG" id="cgr:2888564"/>
    <dbReference type="CGD" id="CAL0131582">
        <property type="gene designation" value="CAGL0H09768g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H09768g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09768g"/>
    <dbReference type="eggNOG" id="KOG4039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071330_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FRC1"/>
    <dbReference type="OMA" id="CIENAKA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014843">
        <property type="entry name" value="Him1/Fmp52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08732">
        <property type="entry name" value="HIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000301818" description="Protein FMP52, mitochondrial">
        <location>
            <begin status="unknown"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="233" mass="25627" checksum="4178D20A6DFF8D26" modified="2004-07-19" version="1" precursor="true">MSKQTAVVLGATGLCGEHLLKSAVASQAFEKVYSISRRSLPYVADCEQIVDKDSSSWASLLPKENFKFLFTSLATTRAAAGGFDKQYQIDHDLNLELAKASKANGCETIVLVSSTGANKNSWMPYLRMKGEIEEDIIALNFKHTIILRPSALLGDRRDHHKGFGNDLFVKIGNCFYRSRLQSIMGYPVQGEEVGIAGVQAALQEAEKNTESPTVRYVGSSEILELVDNFKNNS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRE1</accession>
    <name>TIM13_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial import inner membrane translocase subunit TIM13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TIM13</name>
        <name type="ordered locus">CAGL0H09306g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447203.1">
        <property type="nucleotide sequence ID" value="XM_447203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRE1"/>
    <dbReference type="SMR" id="Q6FRE1"/>
    <dbReference type="FunCoup" id="Q6FRE1">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRE1"/>
    <dbReference type="EnsemblFungi" id="CAGL0H09306g-T">
        <property type="protein sequence ID" value="CAGL0H09306g-T-p1"/>
        <property type="gene ID" value="CAGL0H09306g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888718"/>
    <dbReference type="KEGG" id="cgr:2888718"/>
    <dbReference type="CGD" id="CAL0131900">
        <property type="gene designation" value="CAGL0H09306g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09306g"/>
    <dbReference type="eggNOG" id="KOG1733">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141397_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FRE1"/>
    <dbReference type="OMA" id="RCISQCM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000228072" description="Mitochondrial import inner membrane translocase subunit TIM13">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Twin CX3C motif">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="95" mass="10342" checksum="148F5B86C87285CE" modified="2004-07-19" version="1">MALFGGSSSQAPASATDNKVQAFKQQIAQEIAVANATDLVNKVSENCFEKCLQSPYKDGNEGCVDQCLAKYMRSWNVISKTYINRIQDASTTGEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRG6</accession>
    <name>RL43_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein eL43</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L43</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPL43</name>
        <name type="ordered locus">CAGL0H08734g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRG6"/>
    <dbReference type="SMR" id="Q6FRG6"/>
    <dbReference type="FunCoup" id="Q6FRG6">
        <property type="interactions" value="1145"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRG6"/>
    <dbReference type="EnsemblFungi" id="CAGL0H08734g-T">
        <property type="protein sequence ID" value="CAGL0H08734g-T-p1"/>
        <property type="gene ID" value="CAGL0H08734g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888745"/>
    <dbReference type="CGD" id="CAL0131684">
        <property type="gene designation" value="CAGL0H08734g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H08734g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08734g"/>
    <dbReference type="eggNOG" id="KOG0402">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141199_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FRG6"/>
    <dbReference type="OMA" id="GPRYGRK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000139835" description="Large ribosomal subunit protein eL43">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="92" mass="10111" checksum="F09D4F4A217271CD" modified="2004-07-19" version="1">MAKRTKKVGITGKYGVRYGSSLRRQVKKLEVQQHARYDCSFCGKKTVRRGAAGIWSCHSCKKTVAGGAYTVSTAAAATVRSTIRRLRDMVEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2025-06-18" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRN2</accession>
    <name>DHYS_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Deoxyhypusine synthase</fullName>
            <shortName>DHS</shortName>
            <ecNumber>2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DYS1</name>
        <name type="ordered locus">CAGL0H07249g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447112.1">
        <property type="nucleotide sequence ID" value="XM_447112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRN2"/>
    <dbReference type="SMR" id="Q6FRN2"/>
    <dbReference type="FunCoup" id="Q6FRN2">
        <property type="interactions" value="741"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRN2"/>
    <dbReference type="EnsemblFungi" id="CAGL0H07249g-T">
        <property type="protein sequence ID" value="CAGL0H07249g-T-p1"/>
        <property type="gene ID" value="CAGL0H07249g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888516"/>
    <dbReference type="KEGG" id="cgr:2888516"/>
    <dbReference type="CGD" id="CAL0131840">
        <property type="gene designation" value="DYS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H07249g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07249g"/>
    <dbReference type="eggNOG" id="KOG2924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039781_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRN2"/>
    <dbReference type="OMA" id="HSIINAN"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000003">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000134481" description="Deoxyhypusine synthase">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="108"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="329"/>
            <end position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="335"/>
            <end position="337"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="344"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="363"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="385" mass="42442" checksum="268D7333049605B6" modified="2004-07-19" version="1">MSAANDKLPDILQDAVLKASVPVPDDFVQVKGIDYSAATATDMRASDLVNSMKTMGFQASSLGKACDIIDEMRSWRGKHIDELDEHDRKGQFDDAGYQKTTVFMGYTSNLISSGLRETLRYLVQHKMVDALVATAGGIEEDIIKCLAPTYLGEFSLEGKSLRDQGMNRIGNLLVPNDNYCKFEEWIVPIFDKMLEEQEEYVAKHGKDCLDANTDVDSPIWTPSKLIDRLGKEINDESSVLYWAHKNKIPIFCPAITDGSIGDMLFFHTFKASPKQIRLDIVADIRKINSMSMEASKAGMIILGGGLIKHHIANACLMRNGADYAVYINTGQEFDGSDAGARPDEAVSWGKIKAEAKSVKIYADVTIVFPLIVAATFANGKPLPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRR6</accession>
    <name>Q6FRR6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0H06501g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRR6"/>
    <dbReference type="FunCoup" id="Q6FRR6">
        <property type="interactions" value="950"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRR6"/>
    <dbReference type="KEGG" id="cgr:2888853"/>
    <dbReference type="CGD" id="CAL0130114">
        <property type="gene designation" value="CAGL0H06501g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06501g"/>
    <dbReference type="eggNOG" id="KOG0212">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007740_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRR6"/>
    <dbReference type="OMA" id="ELPGCHF"/>
    <dbReference type="PHI-base" id="PHI:9273"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="556"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="821"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0130114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="868" mass="98577" checksum="97DE81D6376435DD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRU8</accession>
    <name>PNG1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase</fullName>
            <shortName>PNGase</shortName>
            <ecNumber>3.5.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Peptide:N-glycanase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PNG1</name>
        <name type="ordered locus">CAGL0H05753g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue.</text>
            <dbReference type="EC" id="3.5.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.52"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447046.1">
        <property type="nucleotide sequence ID" value="XM_447046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRU8"/>
    <dbReference type="SMR" id="Q6FRU8"/>
    <dbReference type="FunCoup" id="Q6FRU8">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRU8"/>
    <dbReference type="EnsemblFungi" id="CAGL0H05753g-T">
        <property type="protein sequence ID" value="CAGL0H05753g-T-p1"/>
        <property type="gene ID" value="CAGL0H05753g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888806"/>
    <dbReference type="KEGG" id="cgr:2888806"/>
    <dbReference type="CGD" id="CAL0131872">
        <property type="gene designation" value="CAGL0H05753g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05753g"/>
    <dbReference type="eggNOG" id="KOG0909">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031058_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FRU8"/>
    <dbReference type="OMA" id="AWDKPRL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120125">
        <property type="term" value="C:PNGase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097466">
        <property type="term" value="P:ubiquitin-dependent glycoprotein ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000004">
        <property type="entry name" value="Peptidase (PNG1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000248987" description="Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="348" mass="40914" checksum="9AB66746784A9B76" modified="2004-07-19" version="1">MVDPIYVEVADMFLKRYKDYVINLFKEPVPLNRVQKLLQENKFAGELFDMSNRLCTMYENGTWHSQVLETLDLDKIYANVDMMPLEDDSQYSDNLVKELLRYFKQDFFTWCNKPVCKSCGASGDDINGAAIQAPTNEEAKFNCGSVEVYHCQKCNSEVRFPRYNDPIKLLETRTGRCGEWCNLFTLVLKSFGLESRYIWNREDHVWCEYYSPYLKRWIHVDSCEQSFDEPFIYSKNWNKSMSYCIGFWRYGVVDVSKRYILQNQLPRDIIKEDDLQFLCHALTKRLRTGLSDDESYKMYCRDDLEQLELNPSATPTKEMQKLKISKTGNKGRISGSAEWKESRGENGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRW1</accession>
    <name>G6PI_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Glucose-6-phosphate isomerase</fullName>
            <shortName>GPI</shortName>
            <ecNumber evidence="3">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">D-hexose-6-phosphate anomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glucose-6-phosphate C2-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName>Phosphoglucose isomerase</fullName>
            <shortName>PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Phosphohexose isomerase</fullName>
            <shortName>PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PGI1</name>
        <name type="ordered locus">CAGL0H05445g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (By similarity). Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P) (By similarity). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11817"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="3">
            <dbReference type="Rhea" id="RHEA:11818"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:16250"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="3">
            <dbReference type="Rhea" id="RHEA:16251"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-D-fructose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:85579"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:234464"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:85580"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="3">
            <dbReference type="Rhea" id="RHEA:85581"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>alpha-D-mannose 6-phosphate = beta-D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:85583"/>
            <dbReference type="ChEBI" id="CHEBI:60332"/>
            <dbReference type="ChEBI" id="CHEBI:234465"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:85584"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="3">
            <dbReference type="Rhea" id="RHEA:85585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:85575"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:85576"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:85577"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3"/>
    <dbReference type="EC" id="5.1.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447033.1">
        <property type="nucleotide sequence ID" value="XM_447033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRW1"/>
    <dbReference type="SMR" id="Q6FRW1"/>
    <dbReference type="FunCoup" id="Q6FRW1">
        <property type="interactions" value="1272"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRW1"/>
    <dbReference type="EnsemblFungi" id="CAGL0H05445g-T">
        <property type="protein sequence ID" value="CAGL0H05445g-T-p1"/>
        <property type="gene ID" value="CAGL0H05445g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888511"/>
    <dbReference type="KEGG" id="cgr:2888511"/>
    <dbReference type="CGD" id="CAL0129964">
        <property type="gene designation" value="PGI1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H05445g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05445g"/>
    <dbReference type="eggNOG" id="KOG2446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017947_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FRW1"/>
    <dbReference type="OMA" id="DWYRQLW"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016857">
        <property type="term" value="F:racemase and epimerase activity, acting on carbohydrates and derivatives"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1390.10:FF:000001">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000004">
        <property type="entry name" value="Glucose-6-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000180573" description="Glucose-6-phosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="169"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="219"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>D-glucose 6-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P06744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P06745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P12709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="P78917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="5">
        <source>
            <dbReference type="UniProtKB" id="Q9N1E2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="555" mass="61310" checksum="D6237C5392EFF0CA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSA7</accession>
    <name>Q6FSA7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0H02123g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSA7"/>
    <dbReference type="FunCoup" id="Q6FSA7">
        <property type="interactions" value="204"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSA7"/>
    <dbReference type="KEGG" id="cgr:2888450"/>
    <dbReference type="CGD" id="CAL0130374">
        <property type="gene designation" value="CAGL0H02123g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02123g"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016304_7_0_1"/>
    <dbReference type="InParanoid" id="Q6FSA7"/>
    <dbReference type="OMA" id="NKQTXLL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="RRM1_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
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    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="84"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="190"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="327"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0130374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="555" mass="60222" checksum="1FB27B97FA705181" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSB4</accession>
    <name>Q6FSB4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0H01859g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSB4"/>
    <dbReference type="FunCoup" id="Q6FSB4">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSB4"/>
    <dbReference type="KEGG" id="cgr:2888641"/>
    <dbReference type="CGD" id="CAL0131630">
        <property type="gene designation" value="CAGL0H01859g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01859g"/>
    <dbReference type="eggNOG" id="KOG0935">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061221_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FSB4"/>
    <dbReference type="OMA" id="QSNFVEY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000010">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0131630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="147" mass="17405" checksum="B64058C8ABDDE788" modified="2004-07-19" version="1">MAIQFILCFNKQGVVRLLRWYEKVPAGHERTQDVIAQIYRLISSRDHRHQSNFVEFSERTKLVYKRYAGLYFVFGVDLKDEESIYLSHIHLFVEVLDAFFGNVCELDIVFNFYKAYMVMDEMFLGGEVQEVSKDALFERLSALDRLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-12" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSD2</accession>
    <name>CFT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein CFT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cleavage factor two protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CFT1</name>
        <name type="ordered locus">CAGL0H01463g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CFT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446862.1">
        <property type="nucleotide sequence ID" value="XM_446862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSD2"/>
    <dbReference type="SMR" id="Q6FSD2"/>
    <dbReference type="FunCoup" id="Q6FSD2">
        <property type="interactions" value="1221"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSD2"/>
    <dbReference type="EnsemblFungi" id="CAGL0H01463g-T">
        <property type="protein sequence ID" value="CAGL0H01463g-T-p1"/>
        <property type="gene ID" value="CAGL0H01463g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888551"/>
    <dbReference type="KEGG" id="cgr:2888551"/>
    <dbReference type="CGD" id="CAL0130563">
        <property type="gene designation" value="CAGL0H01463g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01463g"/>
    <dbReference type="eggNOG" id="KOG1896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002414_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSD2"/>
    <dbReference type="OMA" id="PMTKFKL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000937">
        <property type="entry name" value="Cft1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000290626" description="Protein CFT1">
        <location>
            <begin position="1"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1361" mass="154576" checksum="3B5A42107C82935A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSI4</accession>
    <name>Q6FSI4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H00286g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446810.1">
        <property type="nucleotide sequence ID" value="XM_446810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSI4"/>
    <dbReference type="STRING" id="284593.Q6FSI4"/>
    <dbReference type="KEGG" id="cgr:2888777"/>
    <dbReference type="CGD" id="CAL0131824">
        <property type="gene designation" value="CAGL0H00286g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00286g"/>
    <dbReference type="eggNOG" id="ENOG502S00X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078856_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FSI4"/>
    <dbReference type="OMA" id="HDWISAN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052841">
        <property type="entry name" value="PMP_oxidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28040:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE YLR456W HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="211" mass="23625" checksum="4C3260C9BB41C7D5" modified="2004-07-19" version="1">MSIISKKFPDDLIALIRSSKYVHVATCSKYCEPSVSLMNYVYLEKPQLFSEFFCADLKGAYEDSDGIDNGYIIFATFDETEKIGNIRENPKVSLLFHDWISANNLSLRKGNPLLNSSGSIEFSPQYSHGNRISNVLNNLEDNELNQMSATITGHARIVDCDSDESTYYMRLLLGANPDADIFILAENAVIVIVKMLDAKVSDNENNVGIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSM6</accession>
    <name>Q6FSM6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylulose kinase</fullName>
            <ecNumber evidence="6">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0G09339g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="6"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSM6"/>
    <dbReference type="FunCoup" id="Q6FSM6">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSM6"/>
    <dbReference type="KEGG" id="cgr:2888034"/>
    <dbReference type="CGD" id="CAL0130679">
        <property type="gene designation" value="CAGL0G09339g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09339g"/>
    <dbReference type="eggNOG" id="KOG2531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016149_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FSM6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000170">
        <property type="entry name" value="D-xylulose kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="7">
        <location>
            <begin position="133"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="8">
        <location>
            <begin position="302"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0130679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="582" mass="65197" checksum="806C9E75DB99E27C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSU8</accession>
    <name>Q6FSU8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Roc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0G07689g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSU8"/>
    <dbReference type="FunCoup" id="Q6FSU8">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSU8"/>
    <dbReference type="KEGG" id="cgr:2888150"/>
    <dbReference type="CGD" id="CAL0129875">
        <property type="gene designation" value="CAGL0G07689g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07689g"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="Q6FSU8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036258">
        <property type="term" value="P:multivesicular body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036010">
        <property type="term" value="P:protein localization to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020859">
        <property type="entry name" value="ROC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51424">
        <property type="entry name" value="ROC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Roc" evidence="13">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="177"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0129875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG59623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="215" mass="23921" checksum="58FEA13F0DF5DF2F" modified="2004-07-19" version="1">MLQFKLVLLGDSSVGKSSIVHRFVKDTFDELRESTIGAAFLSQTVKIKDGNEDVVIKFEIWDTAGQERYKSLAPMYYRNANAALVVYDVTQPDSLSKAQSWVQELQNKVGDEELVIYLVGNKVDIVEADESARKIETEEGAEYAQAQKLLFKEVSAKTGAGVKDIFQEIGEQLYSTKKASLKNKDQSRRTDSVSSNTVDIQTQRPSTNDTSSCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSX0</accession>
    <name>Q6FSX0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0G07205g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSX0"/>
    <dbReference type="FunCoup" id="Q6FSX0">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSX0"/>
    <dbReference type="KEGG" id="cgr:2888172"/>
    <dbReference type="CGD" id="CAL0137627">
        <property type="gene designation" value="CAGL0G07205g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07205g"/>
    <dbReference type="eggNOG" id="KOG1624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FSX0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0137627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="285" mass="32170" checksum="6DF09666A01A75BC" modified="2004-07-19" version="1">MSRSALKSVDRLRLVINTSRNFSSEAAVLPNAAPRPKYTLATVRSFPSLEPNSFIPVSANVLSLPLRRDILWQAVVYENDKRRVGASNPPGRSDKGFSRKKLLPQKGSGKARVGDANSPIRHNGGRALARTAPNDYSTELNKKVYSTAFFTALSHQYKLGNLFVIGKEGEIAKNDVEILDIDLGQKPVPSDKIKPNKMAELENEYCEMYFKKFLAENNLFKQRLLFVTNEPREKLLHASDKYKDKIDIIQKEHLEVNDILRAGKIYIELEALKGISAKYMSYLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT10</accession>
    <name>Q6FT10_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="20">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 26" type="ordered locus">CAGL0G06270g</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="20"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FT10">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT10"/>
    <dbReference type="KEGG" id="cgr:2888146"/>
    <dbReference type="CGD" id="CAL0130725">
        <property type="gene designation" value="CAGL0G06270g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06270g"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FT10"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990530">
        <property type="term" value="C:Cdc50p-Drs2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140345">
        <property type="term" value="F:phosphatidylcholine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090555">
        <property type="term" value="F:phosphatidylethanolamine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 19 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1029"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1069"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1117"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1141"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1184"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="23">
        <location>
            <begin position="168"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="22">
        <location>
            <begin position="264"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="24">
        <location>
            <begin position="961"/>
            <end position="1214"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1284"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1284"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1311"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="17">
        <location>
            <position position="543"/>
        </location>
    </feature>
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        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="543"/>
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        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
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            <name>ATP</name>
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        </ligand>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <ligand>
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        </ligand>
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        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="679"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="702"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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            <name>ATP</name>
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        <location>
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            <name>ATP</name>
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            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <position position="938"/>
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            <name>ATP</name>
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            <name>ATP</name>
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            <name>Mg(2+)</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00122"/>
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    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
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    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="CGD" id="CAL0130725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CAG59561.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1328" mass="150601" checksum="899B9295649CA24E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT35</accession>
    <name>Q6FT35_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GDH2</name>
        <name evidence="7 8" type="ordered locus">CAGL0G05698g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446609.1">
        <property type="nucleotide sequence ID" value="XM_446609.1"/>
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    <dbReference type="AlphaFoldDB" id="Q6FT35"/>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT35"/>
    <dbReference type="GeneID" id="2888100"/>
    <dbReference type="KEGG" id="cgr:2888100"/>
    <dbReference type="CGD" id="CAL0130568">
        <property type="gene designation" value="GDH2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05698g"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005220_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT35"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
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        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
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    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="709"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0130568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1095" mass="124184" checksum="62A9D92D45610E31" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT45</accession>
    <name>Q6FT45_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0G05489g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT45"/>
    <dbReference type="FunCoup" id="Q6FT45">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT45"/>
    <dbReference type="KEGG" id="cgr:2888405"/>
    <dbReference type="CGD" id="CAL0137585">
        <property type="gene designation" value="CAGL0G05489g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05489g"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_7_4_1"/>
    <dbReference type="InParanoid" id="Q6FT45"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032186">
        <property type="term" value="P:cellular bud neck septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061163">
        <property type="term" value="P:endoplasmic reticulum polarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="19"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="464"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="533" mass="60637" checksum="8A009B63341030DD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTC8</accession>
    <name>Q6FTC8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein BOI2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0G03509g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTC8"/>
    <dbReference type="FunCoup" id="Q6FTC8">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTC8"/>
    <dbReference type="KEGG" id="cgr:2888136"/>
    <dbReference type="CGD" id="CAL0130183">
        <property type="gene designation" value="CAGL0G03509g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03509g"/>
    <dbReference type="eggNOG" id="ENOG502QPMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003845_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTC8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001881">
        <property type="term" value="P:receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099500">
        <property type="term" value="P:vesicle fusion to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13316">
        <property type="entry name" value="PH_Boi"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SAM_BOI-like_fungal"/>
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    </dbReference>
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        <property type="entry name" value="SH3_BOI"/>
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        <property type="entry name" value="Polarized growth protein (Boi2)"/>
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        <property type="entry name" value="Protein BOI2"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="SH3 Domains"/>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
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        <property type="entry name" value="Boi1/2_SH3"/>
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        <property type="entry name" value="Boi1/Boi2-like"/>
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        <property type="entry name" value="SAM"/>
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        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902:SF27">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22902">
        <property type="entry name" value="SESQUIPEDALIAN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="37"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="235"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="650"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="801"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="879"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="525"/>
            <end position="536"/>
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            <begin position="554"/>
            <end position="574"/>
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            <begin position="587"/>
            <end position="599"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
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            <begin position="618"/>
            <end position="631"/>
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        <location>
            <begin position="818"/>
            <end position="829"/>
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        <location>
            <begin position="830"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="888"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0130183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="918" mass="100726" checksum="E768189CC278D07C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTD8</accession>
    <name>Q6FTD8_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SSA3</name>
        <name evidence="8 9" type="ordered locus">CAGL0G03289g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG59433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_005965_7_0_1"/>
    <dbReference type="InParanoid" id="Q6FTD8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000135">
        <property type="entry name" value="Heat shock cognate 71 kDa protein"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
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    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Hsp_70_fam"/>
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        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
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    </dbReference>
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        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
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    </dbReference>
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        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="611"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="611"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="647" mass="69848" checksum="B79CC4435CDA6678" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTM6</accession>
    <name>Q6FTM6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0G01298g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTM6"/>
    <dbReference type="FunCoup" id="Q6FTM6">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTM6"/>
    <dbReference type="KEGG" id="cgr:2888056"/>
    <dbReference type="CGD" id="CAL0137543">
        <property type="gene designation" value="CAGL0G01298g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01298g"/>
    <dbReference type="eggNOG" id="ENOG502QQP3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060138_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTM6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0137543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="379" mass="43192" checksum="FEE8C191B7E0E7A9" modified="2004-07-19" version="1">MDSNFTEFEELIDPEFDSKSYSNSMLKAMNTTSNELDIDAPKKKAQYDADELKSRYESFLKSHASGLMDEFDRERKLNGSISAELKPSLEYMSISYNRLLEQVLVPYERAQKLQAALNSVHQTSTLLRDVLMFVHLSQQITSFVPLQGEDKLSAVSISKLASLHYQIQLNQSQHPNLKSLKFVKEMESQTLAPRRKSLLSHITLTISRECLNSIKLRSNENDLKSLLLSLYTLSEQEFYVTLQKIILTNATNTSRILSKSVNAIKTLPSLFEEAVKKGHDVYVIETLLQNVKVENSNLLVQFTRLSRNKASTPRQLYWGKVSSAFKIDLNTAIERGGPVGKQIVNSKTFILDTIKDVFQRMSEEEPDFEHNLQIMIGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTN7</accession>
    <name>Q6FTN7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GAS3</name>
        <name evidence="11 12" type="ordered locus">CAGL0G01056g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <topology evidence="8">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTN7"/>
    <dbReference type="FunCoup" id="Q6FTN7">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTN7"/>
    <dbReference type="CAZy" id="CBM43">
        <property type="family name" value="Carbohydrate-Binding Module Family 43"/>
    </dbReference>
    <dbReference type="CAZy" id="GH72">
        <property type="family name" value="Glycoside Hydrolase Family 72"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888270"/>
    <dbReference type="CGD" id="CAL0130552">
        <property type="gene designation" value="GAS3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01056g"/>
    <dbReference type="eggNOG" id="ENOG502QRZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FTN7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF10">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 8" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005144032" description="1,3-beta-glucanosyltransferase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="10">
        <location>
            <begin position="392"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0130552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="542" mass="61333" checksum="B7483E16046DC366" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU38</accession>
    <name>Q6FU38_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0F06633g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU38"/>
    <dbReference type="FunCoup" id="Q6FU38">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU38"/>
    <dbReference type="KEGG" id="cgr:2887897"/>
    <dbReference type="CGD" id="CAL0130964">
        <property type="gene designation" value="CAGL0F06633g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06633g"/>
    <dbReference type="eggNOG" id="KOG2699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_667421_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU38"/>
    <dbReference type="OMA" id="FPDRTHI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="280"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0130964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="429" mass="48701" checksum="9820D54A4F86E32C" modified="2004-07-19" version="1">MSSVHVHHNVSSLKVPVNGSTTLKDVLNVATKHYNLDPERYTLQKDYETLDLSVPWRFLNMAQNSKFELVEMQVREDNAIAEPPKTIRIRFQIVDRGSFIKELSNNITLDKALQEIIDENQLDFAIHNAHLQCFGRQVPAELLASTTLNSLGIQSASNIKVLITDRDQIAQPHLKRESEESVESPEKIQLVNEKEITEPIKVSKPHELHKPQVYLPPKTSVSERVRNEIDNNIADDDYELTIEHAKLYQSMLAKQTGSLGGPLMTQRMRQMQDNVKNNKHSVDECFIRFKFPDLTQIEISFSPEDTMHTVYNIVRELLISTDLNFGLYRTHPHLLLDDSELRLVADLQFGAKTALLFEPNNKSNKGPYLRGSVIDSGESISNIIDPKINTTADTETEKEPSPTRKVSAAFSSSSTGPKKIPKWLRLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU67</accession>
    <name>Q6FU67_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytokinesis protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0F05885g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU67"/>
    <dbReference type="FunCoup" id="Q6FU67">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU67"/>
    <dbReference type="KEGG" id="cgr:2887667"/>
    <dbReference type="CGD" id="CAL0131070">
        <property type="gene designation" value="CAGL0F05885g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05885g"/>
    <dbReference type="eggNOG" id="KOG2398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_434790_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU67"/>
    <dbReference type="OMA" id="RFAKSWN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000144">
        <property type="term" value="C:cellular bud neck septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044697">
        <property type="term" value="C:HICS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120155">
        <property type="term" value="C:MIH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032038">
        <property type="term" value="F:myosin II heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051126">
        <property type="term" value="P:negative regulation of actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090339">
        <property type="term" value="P:negative regulation of formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031671">
        <property type="term" value="P:primary cell septum biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072741">
        <property type="term" value="P:protein localization to cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903471">
        <property type="term" value="P:regulation of mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="11">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="10">
        <location>
            <begin position="642"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="322"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="522"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="598"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="135"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="522"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0131070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="80615" checksum="AA05A0945974F55C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU72</accession>
    <name>Q6FU72_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0F05775g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU72"/>
    <dbReference type="FunCoup" id="Q6FU72">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU72"/>
    <dbReference type="KEGG" id="cgr:2887599"/>
    <dbReference type="CGD" id="CAL0131358">
        <property type="gene designation" value="CAGL0F05775g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05775g"/>
    <dbReference type="eggNOG" id="ENOG502RYH0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535264_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU72"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="98"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="509" mass="57743" checksum="5B6AEF248ACE6447" modified="2004-07-19" version="1">MKIKAEAGSQDSVRLKRQSSDAGVERFDFDAEEYEIDPRKKLKLVTRGVSSGNSDAVGTQSPDGINAFEKRATISKMILDIKRNDIFGTAPILNAESALDDRKYINYHRRMLRQESRMIQLDITHGENEADRLLGVYDKLNMFNWQPTLLKVTKINDPNDEEEMLAKREKTKEYIQTLLNNFDNMKKRTLSLNKKNAKYVKKIGSEKTMLPNSISRSDSSVFHGPDRTKIYNYVDRKYYSGYVSSSDEEEECMTVEDIKAHRKASRERQCGSALTVCLSNNFNAGYAIVAEPLKKPYIIKCTTQERKHWKNIRGDGDIKKFKVYHPPTTLVANLTQRISCENTLKPKSVNELRNPNEDNEVIDNDQKQYKNADILLPSEDSVLSDVPSSLPRSPSIAPINLLPVKKLLKSTVEETSTLPNYDGNYGELILNSQYQSNDVPHMGYSSEGAGTTTNYLDRTIIQNTGNVEAMPNTRQLPPLGNFHLENNMNATEKNSVVLLSQADKYYPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUB8</accession>
    <name>Q6FUB8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycogen [starch] synthase</fullName>
            <ecNumber evidence="9">2.4.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0F04719g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18549"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:18550"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyltransferase 3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.11" evidence="9"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUB8"/>
    <dbReference type="FunCoup" id="Q6FUB8">
        <property type="interactions" value="484"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUB8"/>
    <dbReference type="CAZy" id="GT3">
        <property type="family name" value="Glycosyltransferase Family 3"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887785"/>
    <dbReference type="CGD" id="CAL0129671">
        <property type="gene designation" value="CAGL0F04719g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04719g"/>
    <dbReference type="eggNOG" id="KOG3742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015910_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FUB8"/>
    <dbReference type="OMA" id="RMHKSNV"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042587">
        <property type="term" value="C:glycogen granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000045">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000177">
        <property type="entry name" value="Glycogen [starch] synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008631">
        <property type="entry name" value="Glycogen_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176:SF3">
        <property type="entry name" value="GLYCOGEN [STARCH] SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10176">
        <property type="entry name" value="GLYCOGEN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05693">
        <property type="entry name" value="Glycogen_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0129671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="704" mass="80427" checksum="BB9D22A81F0DF6AF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUG5</accession>
    <name>Q6FUG5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">54S ribosomal protein L40, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0F03663g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUG5"/>
    <dbReference type="FunCoup" id="Q6FUG5">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUG5"/>
    <dbReference type="KEGG" id="cgr:2887735"/>
    <dbReference type="CGD" id="CAL0129487">
        <property type="gene designation" value="CAGL0F03663g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03663g"/>
    <dbReference type="eggNOG" id="ENOG502QUDZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046293_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUG5"/>
    <dbReference type="OMA" id="KEWKFIP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22682">
        <property type="entry name" value="Ribosomal_uL24m-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0129487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33742" checksum="CDD10B2763DC5537" modified="2004-07-19" version="1">MPRYDHLSKAGSRFLKHLENVPKRGQRRAEQFMNKALPEFVRPNNRTVPEEQRFADETHWKFVPGDRVVITHGKYKGTVAVIKDLEVATNSFILDGNGPSRKVPVAKQYWLENQSTHMLSLPVSLKRKHLKLLADIDDPANPGQTKTVAVKDVTFDAGTYYDKDRKKVMPYRCVVGRPDLVVPWPTPEPKPDGVLGTEPKLARQQTFWVDTIVRNSIPKNAFLTLRNPHSKYKKKLLTAKDIAKLVAPKMPLSDTKKKFLEEKEMLAKREKPQLTEADIELIGSRVKEFLETAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUI9</accession>
    <name>Q6FUI9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0F03113g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUI9"/>
    <dbReference type="FunCoup" id="Q6FUI9">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUI9"/>
    <dbReference type="KEGG" id="cgr:2887820"/>
    <dbReference type="CGD" id="CAL0129958">
        <property type="gene designation" value="CAGL0F03113g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03113g"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014456_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FUI9"/>
    <dbReference type="OMA" id="DFKDPWG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010009">
        <property type="term" value="C:cytoplasmic side of endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="109"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="476"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0129958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="647" mass="73273" checksum="1B5AC882864D5416" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUK3</accession>
    <name>Q6FUK3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">E3 SUMO-protein ligase SIZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0F02783g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUK3"/>
    <dbReference type="STRING" id="284593.Q6FUK3"/>
    <dbReference type="KEGG" id="cgr:2887721"/>
    <dbReference type="CGD" id="CAL0130942">
        <property type="gene designation" value="CAGL0F02783g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02783g"/>
    <dbReference type="eggNOG" id="KOG2169">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_338886_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUK3"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="142"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="328"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="474"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="817"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0130942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="839" mass="94466" checksum="8B242BEC5D86670E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUZ8</accession>
    <name>Q6FUZ8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHO85 cyclin-8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0E05918g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUZ8"/>
    <dbReference type="FunCoup" id="Q6FUZ8">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUZ8"/>
    <dbReference type="KEGG" id="cgr:2887440"/>
    <dbReference type="CGD" id="CAL0128854">
        <property type="gene designation" value="CAGL0E05918g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05918g"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043984_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUZ8"/>
    <dbReference type="OMA" id="RINAKCM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF123">
        <property type="entry name" value="PHO85 CYCLIN-10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="53674" checksum="EAF42DF3B0E3F205" modified="2004-07-19" version="1">MTVQEDVDKDDGEGGDSHPDGFSDNFGKDHKGMGFGDYLMYSQEDSLFELPIKTGYNLNFSELNDSLPASNVPQLSQPSKKVRFENDEIEHDGNGSATSVSRDMDGSNGDNEDGVNTSQDDDLELSPKASANGKPREDIENLIQKASVFNEVLGENLAKLNTLSSDGLPSRVMSRMGSEMSTARSDSMSCFALSDSEGDGELMLDSGHSGSDPFTHSNILSQINGEYSEDDGVLLLSPYQSSTMYNNFIDTEIGPASSTERVNEEQFFEISPPENFQAGGNKTSDIVHDNTCVLLSKYQHNNEIFEYSVEDTMHNYTETLDILLRLSENENMISEKADNNENYHYFSMKSAPSISHHDFIQRIQNKCMFGSIIYLGATYLLQILFLTREYNDGPLRLKHKLQQNEVHRVIVGTIRIATKLLEDFVHSHQYICKVCGISKKLMTKLELALIFCLKDNNLLINSEKLSATACILEELKAQESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV61</accession>
    <name>Q6FV61_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein AHC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0E04488g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV61"/>
    <dbReference type="FunCoup" id="Q6FV61">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV61"/>
    <dbReference type="KEGG" id="cgr:2887482"/>
    <dbReference type="CGD" id="CAL0128898">
        <property type="gene designation" value="CAGL0E04488g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04488g"/>
    <dbReference type="eggNOG" id="ENOG502QWTP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036203_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FV61"/>
    <dbReference type="OMA" id="QHHRRNY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140671">
        <property type="term" value="C:ADA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058708">
        <property type="entry name" value="AHC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058707">
        <property type="entry name" value="AHC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25911">
        <property type="entry name" value="AHC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25910">
        <property type="entry name" value="AHC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHC1 N-terminal" evidence="3">
        <location>
            <begin position="58"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AHC1-like C2H2 zinc-finger" evidence="2">
        <location>
            <begin position="257"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="AHC1 C-terminal" evidence="4">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0128898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG58802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="62354" checksum="A5ABFB27F985CF5C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2025-06-18" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV81</accession>
    <name>COFI_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">COF1</name>
        <name type="ordered locus">CAGL0E04048g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
        <text evidence="1">Throughout the cytoplasm (but not on the cytoplasmic cables) and major component of the cortical actin cytoskeleton.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445863.1">
        <property type="nucleotide sequence ID" value="XM_445863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV81"/>
    <dbReference type="SMR" id="Q6FV81"/>
    <dbReference type="FunCoup" id="Q6FV81">
        <property type="interactions" value="854"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV81"/>
    <dbReference type="EnsemblFungi" id="CAGL0E04048g-T">
        <property type="protein sequence ID" value="CAGL0E04048g-T-p1"/>
        <property type="gene ID" value="CAGL0E04048g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887320"/>
    <dbReference type="KEGG" id="cgr:2887320"/>
    <dbReference type="CGD" id="CAL0128806">
        <property type="gene designation" value="COF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_E04048g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04048g"/>
    <dbReference type="eggNOG" id="KOG1735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094004_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FV81"/>
    <dbReference type="OMA" id="ITFYSWS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000060">
        <property type="entry name" value="Cofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000255622" description="Cofilin">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="ADF-H" evidence="2">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="143" mass="15902" checksum="AC7B029F62CCFBFB" modified="2004-07-19" version="1">MSRSGVAVADESIQAFNDLKLGMKYKFVLFSLNDAKTEIVVKETSSDPSYDAFLEKLPENDCLYAVYDFEYQISESEGKRSKIVFFTWSPDTASVRPKMVYASSKDALKRALNGVAIEIQGTDFSEVSYEAVLEKVSRGAGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVU0</accession>
    <name>Q6FVU0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0D05632g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVU0"/>
    <dbReference type="FunCoup" id="Q6FVU0">
        <property type="interactions" value="381"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVU0"/>
    <dbReference type="KEGG" id="cgr:2887090"/>
    <dbReference type="CGD" id="CAL0128225">
        <property type="gene designation" value="CAGL0D05632g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05632g"/>
    <dbReference type="eggNOG" id="KOG3496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149618_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FVU0"/>
    <dbReference type="OMA" id="CCVCKPE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903136">
        <property type="term" value="F:cuprous ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0128225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="55" mass="6362" checksum="113299BB87991DF8" modified="2004-07-19" version="1">MSEPQKEDKPKPCCVCLPEKEARDQCLLFDGQESAKCKELIEKYKSCMKTYGFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVW5</accession>
    <name>Q6FVW5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0D05016g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVW5"/>
    <dbReference type="FunCoup" id="Q6FVW5">
        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVW5"/>
    <dbReference type="KEGG" id="cgr:2886997"/>
    <dbReference type="CGD" id="CAL0128519">
        <property type="gene designation" value="CAGL0D05016g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05016g"/>
    <dbReference type="eggNOG" id="KOG2974">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058264_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVW5"/>
    <dbReference type="OMA" id="FVKQRFY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0128519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25638" checksum="202E739EBBDF6CD7" modified="2004-07-19" version="1">MTTLKHKTKKEEETNSSAEEYSGAEASSSDVDASGSEESQGEDNEDEDGDEEEGDEEEDEDFPRKKKAKMNKHDDGSAGFSQALNAILGSHLKAYDRKDPIMSRNKSVLKQNESQKLELKAKKALLAEKKKLLNKTRKKEVIPTVSDENKSGEEIRKIIEKETRLRKIAQKGAVKLFNAILSTQVKTEKEVSEGFTDIKNRKEKKQLITEVSKEKFLDMVKAAADDDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVZ6</accession>
    <name>UTP25_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName>U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>U three protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">UTP25</name>
        <name type="ordered locus">CAGL0D04180g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445598.1">
        <property type="nucleotide sequence ID" value="XM_445598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVZ6"/>
    <dbReference type="FunCoup" id="Q6FVZ6">
        <property type="interactions" value="1339"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVZ6"/>
    <dbReference type="EnsemblFungi" id="CAGL0D04180g-T">
        <property type="protein sequence ID" value="CAGL0D04180g-T-p1"/>
        <property type="gene ID" value="CAGL0D04180g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887158"/>
    <dbReference type="KEGG" id="cgr:2887158"/>
    <dbReference type="CGD" id="CAL0128371">
        <property type="gene designation" value="CAGL0D04180g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D04180g"/>
    <dbReference type="eggNOG" id="KOG2340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018705_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FVZ6"/>
    <dbReference type="OMA" id="GIMIFIP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000408110" description="U3 small nucleolar RNA-associated protein 25">
        <location>
            <begin position="1"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="700" mass="81426" checksum="9203D5711511A9E6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW18</accession>
    <name>Q6FW18_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MoaB/Mog domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAGL0D03696g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW18"/>
    <dbReference type="FunCoup" id="Q6FW18">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW18"/>
    <dbReference type="KEGG" id="cgr:2887204"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW18"/>
    <dbReference type="OMA" id="EGWAPGC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042726">
        <property type="term" value="P:flavin-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47675:SF1">
        <property type="entry name" value="MOLYBDOPTERIN BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="1">
        <location>
            <begin position="7"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="275" mass="31583" checksum="5A95D19C8D6245A6" modified="2004-07-19" version="1">MGKISAACVIIGDEILNGKVIDKNSSFFAKFCYDQGIQLNSIVTIGDDEDQIVRTIKELSKRYQFIVTTGGIGPTHDDITYESIAKCFNLQCRIDEETKKRMAMKSNPESRLDPESLKDYYRMATLPSGPDVKKYYVADDLWVPICSINQQVYIFPGIPQLFSRMLMEFLPTLECIYKLDDDKREYKRYFVKTKLSESELSRHLRNFQEEATVHSNEIKLGSYPHFGMGFNTVSILGEKKDDEYLRGLKDKIIGILNGEEISEEQESKFSNGNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW81</accession>
    <name>Q6FW81_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0D02266g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW81"/>
    <dbReference type="FunCoup" id="Q6FW81">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW81"/>
    <dbReference type="KEGG" id="cgr:2887247"/>
    <dbReference type="CGD" id="CAL0128089">
        <property type="gene designation" value="CAGL0D02266g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02266g"/>
    <dbReference type="eggNOG" id="ENOG502QZN7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061844_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW81"/>
    <dbReference type="OMA" id="DFIWYSI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031349">
        <property type="entry name" value="Tfb6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781:SF1">
        <property type="entry name" value="ADR380WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37781">
        <property type="entry name" value="TFIIH COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17110">
        <property type="entry name" value="TFB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="311" mass="35778" checksum="153150D223ACC0D6" modified="2004-07-19" version="1">MSEPPTPVHAGPNEQLDIDDIKELSDEDIEELDLKPDMDTDSLSEKHQGEYVQENGAVKREHSILSNEELYGEDERSDFQPRVNINSPFSSYANLRALDDRARPKPQRRLSMSQQSKFIAYCDQKLMDIQRKFVQSRGLNTQNGYQGLEPLLQDVKCLVDFIWYSLDGSPNTDVLLTEELQSDDSMGMKMNNNNMAKDTYFGQSSYLIKIADDLLDYIEKFDLKFLSGEELHQTLSKLFKLLFILDRIFSKLIDGDIPGGKRLNGTESVRVNGIAERTRMKLPVIFESQDLHGYHFEVSKVYENTLERCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW89</accession>
    <name>Q6FW89_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAGL0D02090g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW89"/>
    <dbReference type="FunCoup" id="Q6FW89">
        <property type="interactions" value="1509"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW89"/>
    <dbReference type="eggNOG" id="KOG0279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_7_1"/>
    <dbReference type="InParanoid" id="Q6FW89"/>
    <dbReference type="OMA" id="NCKLKIN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000615">
        <property type="entry name" value="Receptor for activated C kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="103"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="249"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="277" mass="30088" checksum="7142EE23DC670D45" modified="2004-07-19" version="1">MASNEVLVLRGTLEGHNGWVTSLATSAGQPNLLLSASRDKTLISWKLTGDDQKFGVPVKSFKGHSHIVQDCTLTENGAYALSGSWDKTLRLWDVATGETFQTFVGHKGDVMSVAIDKKASMIISGSRDKSIKVWSIKGDCLATLIGHNDWVSQVRIANSSDDDDKVTVISAGNDKMVKVLWNSAAKVPMYTLSAGDEVYALSFSPNRYWLCAATASGIKIFSLDPQCLLDDLKPEFAGYTQSAEPHAVSLAWSSDGQTLFAGYTDNVIRVWQVMTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWB0</accession>
    <name>Q6FWB0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0D01584g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWB0"/>
    <dbReference type="FunCoup" id="Q6FWB0">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWB0"/>
    <dbReference type="KEGG" id="cgr:2887113"/>
    <dbReference type="CGD" id="CAL0128527">
        <property type="gene designation" value="CAGL0D01584g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01584g"/>
    <dbReference type="eggNOG" id="ENOG502RYTK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074165_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWB0"/>
    <dbReference type="OMA" id="NAGTWED"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051938">
        <property type="entry name" value="Apopto_cytoskel_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44145:SF3">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY A MEMBER 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="56"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="300" mass="34664" checksum="FE6A360DA0C438E0" modified="2004-07-19" version="1">MLVKGSTKFLMAHRHDSMLLNKIRCYATTDDNNLVSAGKGSQVLHDSLWPDKHNPTPYEIFGFGVGTHVDLKKLKMEYHKYVKMYHPDLSSHIQIRKSSLVKSHHAMEIANTAQYLTQAEKIQRFKLVTQAYEILKDPRKKNLYDCTRSGWDMAGSAGPTGAQSAYYASSAAYNNFSDQSYAYWNAGNWEDVHNYQNNSGQKLDPWTLLMWFGGLLLCLEGSSLLARIEDTLTDKSITEDNIEVELGQCYINYGLDTDKWSRLRRFLWFRTFNMYRSKVDLDREAEKNEDLIKTLQEKVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWF3</accession>
    <name>BRE1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>E3 ubiquitin-protein ligase BRE1</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase BRE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">BRE1</name>
        <name type="ordered locus">CAGL0D00638g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BRE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445441.1">
        <property type="nucleotide sequence ID" value="XM_445441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWF3"/>
    <dbReference type="SMR" id="Q6FWF3"/>
    <dbReference type="FunCoup" id="Q6FWF3">
        <property type="interactions" value="1003"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWF3"/>
    <dbReference type="EnsemblFungi" id="CAGL0D00638g-T">
        <property type="protein sequence ID" value="CAGL0D00638g-T-p1"/>
        <property type="gene ID" value="CAGL0D00638g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887150"/>
    <dbReference type="KEGG" id="cgr:2887150"/>
    <dbReference type="CGD" id="CAL0128055">
        <property type="gene designation" value="CAGL0D00638g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00638g"/>
    <dbReference type="eggNOG" id="KOG0978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019713_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FWF3"/>
    <dbReference type="OMA" id="ERHRACR"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000414">
        <property type="entry name" value="E3 ubiquitin protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08647">
        <property type="entry name" value="BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000055849" description="E3 ubiquitin-protein ligase BRE1">
        <location>
            <begin position="1"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-type" evidence="3">
        <location>
            <begin position="641"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="127"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="251"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="483"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q07457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="693" mass="79771" checksum="438ADBCFDA920CDB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX95</accession>
    <name>Q6FX95_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Protein disulfide-isomerase</fullName>
            <ecNumber evidence="5 14">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PDI1</name>
        <name evidence="17 18" type="ordered locus">CAGL0B00704g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="5 14"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445001.1">
        <property type="nucleotide sequence ID" value="XM_445001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX95"/>
    <dbReference type="FunCoup" id="Q6FX95">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX95"/>
    <dbReference type="GeneID" id="2886594"/>
    <dbReference type="KEGG" id="cgr:2886594"/>
    <dbReference type="CGD" id="CAL0127006">
        <property type="gene designation" value="PDI1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B00704g"/>
    <dbReference type="eggNOG" id="KOG0190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025879_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FX95"/>
    <dbReference type="OMA" id="FFGMKKD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106055">
        <property type="term" value="C:mannosyl-oligosaccharide 1,2-alpha-mannosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900103">
        <property type="term" value="P:positive regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005144037" description="Protein disulfide-isomerase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="14"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="16">
        <location>
            <begin position="361"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="58"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="403"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0127006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG57901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="523" mass="58014" checksum="7FB04CFC21469480" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXP8</accession>
    <name>Q6FXP8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peroxisomal acyl-coenzyme A thioester hydrolase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0B04059g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXP8"/>
    <dbReference type="FunCoup" id="Q6FXP8">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXP8"/>
    <dbReference type="KEGG" id="cgr:2886669"/>
    <dbReference type="CGD" id="CAL0127704">
        <property type="gene designation" value="CAGL0B04059g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04059g"/>
    <dbReference type="eggNOG" id="KOG3016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032690_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FXP8"/>
    <dbReference type="OMA" id="QVWFRTN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025652">
        <property type="entry name" value="TesB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02551">
        <property type="entry name" value="Acyl_CoA_thio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="5">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase 2 C-terminal" evidence="4">
        <location>
            <begin position="198"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0127704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39638" checksum="C411CF13A909C865" modified="2004-07-19" version="1">MSFAKYSLEKILELVPVTSTRFVTRYLPSAPVGARGTFGGTLVAQSLLASLHTVPVNFHPTSLHCYFINGGDPRSMITYEVKDLRNGKNFIHKQVRAYQHEKLVFASMILFSVKKSQEHDSLHHLKRLKESNKPEIEDLVDAGKLFKDEVVGNLVKFQNIAPEKFNNVSILNKYIESFDEGPMEYKFPKDFFHSTKVTDHLDYVVKIRHPVLSQDDGDAQSQHASKHHFHGHGKIPDKVTPANDPRYNYVAFAYLSDSYILLTIPYFHKLPLYCHKFSVSLDHVIHFHQLPSVNEWLYTEITNPRSNFDKHLVQGDYYDTTGEIVASVSQEGFVVYDSEPILRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXS9</accession>
    <name>Q6FXS9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0A04433g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXS9"/>
    <dbReference type="FunCoup" id="Q6FXS9">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXS9"/>
    <dbReference type="PeroxiBase" id="4434">
        <property type="entry name" value="Cgl1CysPrx"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886338"/>
    <dbReference type="CGD" id="CAL0126821">
        <property type="gene designation" value="CAGL0A04433g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04433g"/>
    <dbReference type="eggNOG" id="KOG0854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FXS9"/>
    <dbReference type="OMA" id="RLTMLYP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF121">
        <property type="entry name" value="ALKYL HYDROPEROXIDE REDUCTASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="48"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0126821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG57853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="260" mass="29458" checksum="79F38AEEC12885B4" modified="2004-07-19" version="1">MSTFMRQYARNMARVPVSTRLNAQRFACANYRFYSEKTNYKQADQPRLRINSSAPNFDADTSHGKINLYDYLGDSWGILFSHPADFTPVCTTEMGAFAKMKPQFDKRGVKLLGLSVEDAESHRKWIKDIEEINGIDKFGFPIIADTKRHVAFLYDMCDEEGFGNINDGSLTTVRSVYVIDPAKKIRVIFTYPSQVGRNTAEVLRVIDALQTADKHGVVTPGNWSPNDDVIIPPKVSDAEASEKFGDFKTVKSYLRYTKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXU0</accession>
    <name>Q6FXU0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RTG2</name>
        <name evidence="3 4" type="ordered locus">CAGL0A04785g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444976.1">
        <property type="nucleotide sequence ID" value="XM_444976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXU0"/>
    <dbReference type="FunCoup" id="Q6FXU0">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXU0"/>
    <dbReference type="GeneID" id="2886411"/>
    <dbReference type="KEGG" id="cgr:2886411"/>
    <dbReference type="CGD" id="CAL0126863">
        <property type="gene designation" value="RTG2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04785g"/>
    <dbReference type="eggNOG" id="ENOG502QRXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033165_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXU0"/>
    <dbReference type="OMA" id="CNRWGGD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000191">
        <property type="entry name" value="Retrograde regulation protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050273">
        <property type="entry name" value="GppA/Ppx_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057512">
        <property type="entry name" value="RTG2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005">
        <property type="entry name" value="EXOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30005:SF0">
        <property type="entry name" value="RETROGRADE REGULATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23566">
        <property type="entry name" value="RTG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx/GppA phosphatase N-terminal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="RTG2 C-terminal" evidence="2">
        <location>
            <begin position="348"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0126863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG57869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="600" mass="67048" checksum="9CAA15D2E0E74221" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXV5</accession>
    <name>Q6FXV5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CKB1</name>
        <name evidence="5 6" type="ordered locus">CAGL0A00275g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444784.1">
        <property type="nucleotide sequence ID" value="XM_444784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXV5"/>
    <dbReference type="FunCoup" id="Q6FXV5">
        <property type="interactions" value="754"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXV5"/>
    <dbReference type="GeneID" id="2886490"/>
    <dbReference type="KEGG" id="cgr:2886490"/>
    <dbReference type="CGD" id="CAL0126623">
        <property type="gene designation" value="CKB1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A00275g"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034027_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FXV5"/>
    <dbReference type="OMA" id="QNGSPMA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030291">
        <property type="term" value="F:protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051873">
        <property type="term" value="P:killing by host of symbiont cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0126623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG57675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="266" mass="30648" checksum="DB915EAC8D9B2549" modified="2004-07-19" version="1">MSEYMEDNSHSDDSGTYDEWIPSFCSRFGHEYFCQVPTDFIEDDFNMTSLAQEVPHYRKALDLILDLEMVSDEEDMDEKESGAESSSGANNNGGVNSKALVNRNIIGHAAEQLYGLIHARYILTKPGLQAMAEKFDHKDFGTCPRYFCHGMQLLPCGLSDTIGKQAVRLYCPSCQDLYLPQSSRHLCLEGAYWGTSFPGVFLKHFKELEEYVERKNKESYELKVFGFRINDQAVSGPRMKWLRQYPVTEEDWEEFNKCEFEMPIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY08</accession>
    <name>Q6FY08_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inhibitor of glycogen debranching 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0A02002g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444852.1">
        <property type="nucleotide sequence ID" value="XM_444852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY08"/>
    <dbReference type="FunCoup" id="Q6FY08">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886344"/>
    <dbReference type="CGD" id="CAL0126683">
        <property type="gene designation" value="CAGL0A02002g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02002g"/>
    <dbReference type="HOGENOM" id="CLU_1981364_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY08"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0126683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG57745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="15029" checksum="A45E8A2632EF640E" modified="2004-07-19" version="1">MMNHSYTHIEEAPEAKEQDIQTPPQFLNRRRSSNYIDALSSKRNEESDPISMDMQNARHQLSSIEQSDHDSKTSNCNKVAEEDEVDYMKRNNHSRQQERPLTGRRRSSFEYEDFKKNIYNRSKLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY12</accession>
    <name>Q6FY12_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0A01892g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444848.1">
        <property type="nucleotide sequence ID" value="XM_444848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY12"/>
    <dbReference type="KEGG" id="cgr:2886419"/>
    <dbReference type="CGD" id="CAL0126573">
        <property type="gene designation" value="CAGL0A01892g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01892g"/>
    <dbReference type="HOGENOM" id="CLU_2468832_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY12"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0126573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG57741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="88" mass="9725" checksum="05690762B868D938" modified="2004-07-19" version="1">MGHSPQTHHRHNKGKQSPPESALQKPALSTTYLTLSGKGPGVLYTANVERPQVFTHLSHYLGIVLLSKVAFLKVFPNRVIDHVITMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FYB0</accession>
    <name>Q6FYB0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0A03168g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). The 5 acidic ribosomal P-proteins form the stalk structure of the 60S subunit. They are organized as a pentameric complex in which uL10/P0 interacts with 2 heterodimers, P1A-P2B and P1B-P2A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FYB0"/>
    <dbReference type="FunCoup" id="Q6FYB0">
        <property type="interactions" value="1054"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FYB0"/>
    <dbReference type="KEGG" id="cgr:2886331"/>
    <dbReference type="CGD" id="CAL0126943">
        <property type="gene designation" value="CAGL0A03168g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A03168g"/>
    <dbReference type="eggNOG" id="KOG3449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FYB0"/>
    <dbReference type="OMA" id="MKVIASY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0126943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG57798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="109" mass="10961" checksum="876C103E71E30674" modified="2004-07-19" version="1">MKYLAAYLLLTQGGNESPAAADIKKVIESVGIEADEARINELLSALEGKSLDELIAEGQQKFASVPVGGAAAGGASAAAGGAAAGEAAEEKEEEAAEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>B4UMX7</accession>
    <name>B4UMX7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">CAGL0B03611g</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAR58001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UMX7"/>
    <dbReference type="HOGENOM" id="CLU_2903983_0_0_1"/>
    <dbReference type="InParanoid" id="B4UMX7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAR58001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="62" mass="6515" checksum="4EA8AFFBDF921D47" modified="2008-09-23" version="1">MALSAHCLKSLVKGMHTNMSLCTPWPCVFGAQWYCVSDFKGQSRLASAGIPSITGVGGAIPM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1996-10-01" modified="2025-06-18" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>P50857</accession>
    <accession>Q8NJS9</accession>
    <name>TRPF_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName>PRAI</shortName>
            <ecNumber>5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TRP1</name>
        <name type="ordered locus">CAGL0C04092g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1995" name="Gene" volume="165" first="203" last="206">
            <title>Cloning of the Candida glabrata TRP1 and HIS3 genes, and construction of their disruptant strains by sequential integrative transformation.</title>
            <authorList>
                <person name="Kitada K."/>
                <person name="Yamaguchi E."/>
                <person name="Arisawa M."/>
            </authorList>
            <dbReference type="PubMed" id="8522176"/>
            <dbReference type="DOI" id="10.1016/0378-1119(95)00552-H"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Proc. Natl. Acad. Sci. U.S.A." volume="99" first="9272" last="9277">
            <title>Gene order evolution and paleopolyploidy in hemiascomycete yeasts.</title>
            <authorList>
                <person name="Wong S."/>
                <person name="Butler G."/>
                <person name="Wolfe K.H."/>
            </authorList>
            <dbReference type="PubMed" id="12093907"/>
            <dbReference type="DOI" id="10.1073/pnas.142101099"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24"/>
    <dbReference type="EMBL" id="U31471">
        <property type="protein sequence ID" value="AAC49146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF520060">
        <property type="protein sequence ID" value="AAM74212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PIR" id="JC4380">
        <property type="entry name" value="JC4380"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445353.1">
        <property type="nucleotide sequence ID" value="XM_445353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P50857"/>
    <dbReference type="SMR" id="P50857"/>
    <dbReference type="FunCoup" id="P50857">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="284593.P50857"/>
    <dbReference type="EnsemblFungi" id="CAGL0C04092g-T">
        <property type="protein sequence ID" value="CAGL0C04092g-T-p1"/>
        <property type="gene ID" value="CAGL0C04092g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886909"/>
    <dbReference type="KEGG" id="cgr:2886909"/>
    <dbReference type="CGD" id="CAL0127496">
        <property type="gene designation" value="TRP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04092g"/>
    <dbReference type="eggNOG" id="KOG4202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076364_1_0_1"/>
    <dbReference type="InParanoid" id="P50857"/>
    <dbReference type="OMA" id="FHGDESP"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000199">
        <property type="entry name" value="Phosphoribosylanthranilate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894:SF1">
        <property type="entry name" value="N-(5'-PHOSPHORIBOSYL)ANTHRANILATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000154331" description="N-(5'-phosphoribosyl)anthranilate isomerase">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC49146." evidence="1" ref="1">
        <original>GEK</original>
        <variation>VKE</variation>
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="217" mass="23830" checksum="BF4AD8B89AF81184" modified="2004-08-31" version="2">MSFDSLLDKNDKLVKVCGIQTVEAAETALQAGADLIGIICVPNRKRTIESAVAREISKLIHKSGTTKLVGVFRNQSVEDVHRLSEEYDLDIIQLHGDESWPEYYNVIKKPIIKRVIFPRDVDVVTQVCQRKPLVCLPLFDSEAGGTGEKLDWSSISSWASEQNNVFYILAGGLTAENVMEAVGLPGVIGVDVSGGVETDGVKDNDKIIKYVQNAKKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-30" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIW0</accession>
    <name>ATG27_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATG27</name>
        <name type="ordered locus">CAGL0M11352g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling. Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Cycles among the pre-autophagosomal structure (PAS), mitochondria and Golgi.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449834.1">
        <property type="nucleotide sequence ID" value="XM_449834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIW0"/>
    <dbReference type="FunCoup" id="Q6FIW0">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIW0"/>
    <dbReference type="GlyCosmos" id="Q6FIW0">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0M11352g-T">
        <property type="protein sequence ID" value="CAGL0M11352g-T-p1"/>
        <property type="gene ID" value="CAGL0M11352g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891403"/>
    <dbReference type="KEGG" id="cgr:2891403"/>
    <dbReference type="CGD" id="CAL0136241">
        <property type="gene designation" value="CAGL0M11352g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M11352g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11352g"/>
    <dbReference type="eggNOG" id="ENOG502QVJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089705_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIW0"/>
    <dbReference type="OMA" id="NKGNAID"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000001776" description="Autophagy-related protein 27">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="222"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="3">
        <location>
            <begin position="19"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="71"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="276" mass="30428" checksum="269379AD631E5BD9" modified="2004-07-19" version="1" precursor="true">MVMLGQVVALAMASSAVALNCKNHNVLSNYNVANKDILLKNELDTPPSKTSEMWYLAPCEDGSRRQRPSECSSDDLMCAIRHVKVDGSDHLTQKLDVHKSAKYEVEEVESGGFDIRFLGVKWGSNTIDATLSYSCDTNLKTDELVTTIWNSEYVLIEMSGPSGCKRDGNSDSGDNGNGNGNGNDPDNNNNTGKDKKSKKTSWFTWLFVYAILFTVIYLMVVSYLNTKGGSFQDFRNEFVERGTEFITSLPTFVKEVVTKTLGTRDSSASRGGYSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIZ9</accession>
    <name>Q6FIZ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M10307g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449795.1">
        <property type="nucleotide sequence ID" value="XM_449795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIZ9"/>
    <dbReference type="FunCoup" id="Q6FIZ9">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIZ9"/>
    <dbReference type="KEGG" id="cgr:2891359"/>
    <dbReference type="CGD" id="CAL0136931">
        <property type="gene designation" value="CAGL0M10307g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M10307g"/>
    <dbReference type="eggNOG" id="ENOG502QPQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030747_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FIZ9"/>
    <dbReference type="OMA" id="PHIWISI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045140">
        <property type="term" value="F:inositol phosphoceramide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="186"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="448" mass="51223" checksum="7318C3029AB99414" modified="2004-07-19" version="1">MFLKVRDWFLKDRPANHSATDLEYGWNPMESVRYLRSQYRHYKANPHLLSYKDVCHYTFMGSVWLFVLIMNPAPMVLKLLFYAFLTLLFLVPITSQFFFNALPILTWLALYFTSSYLKADIRPPITVKALPAIETVLYGDNLSDILATSTNPVLDIFAWIPYGLFHFGAPFVVALILFLFGPPTILKGYAFAFGYMNLIGVMIQNFFPAAPPWYKILYGLESANYTMKGSPGGLARIDELLHINLYSNAFANSSVIFGAFPSLHSGCATMEALFFSYCFPFLRPLFIFYVCWLWWSTMYLTHHYFVDLMAGSVLSYVIFQYTKYYHLPVVNTSYLTRWAYPSVSKYDFKTSDPLNTDSEMHVENIPLRTYDETMSIDSRSNSNGRLELELDMDMDNMRTVSSNTSTPASVFDRMESLSRSSATSNTSLGNLSTTDLTDPPVARKPSAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-06-28" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ26</accession>
    <name>YIM1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein YIM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">YIM1</name>
        <name type="ordered locus">CAGL0M09713g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449768.1">
        <property type="nucleotide sequence ID" value="XM_449768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ26"/>
    <dbReference type="SMR" id="Q6FJ26"/>
    <dbReference type="FunCoup" id="Q6FJ26">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ26"/>
    <dbReference type="EnsemblFungi" id="CAGL0M09713g-T">
        <property type="protein sequence ID" value="CAGL0M09713g-T-p1"/>
        <property type="gene ID" value="CAGL0M09713g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891332"/>
    <dbReference type="KEGG" id="cgr:2891332"/>
    <dbReference type="CGD" id="CAL0137015">
        <property type="gene designation" value="CAGL0M09713g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M09713g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09713g"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_3_1"/>
    <dbReference type="InParanoid" id="Q6FJ26"/>
    <dbReference type="OMA" id="GPLTYFT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018455">
        <property type="term" value="F:alcohol dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08247">
        <property type="entry name" value="AST1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0551">Lipid droplet</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000409675" description="Protein YIM1">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="368" mass="41849" checksum="FC365E8C9D1148EA" modified="2004-07-19" version="1">MVQQRSITFVDGYSKPAITTTELDLDNCFKDDEIVIKVKCCAINPIDMVVYGLSTTWLTGCKPKTFGRDFSGVIVRAGSRVDPQWKVDDEVNGQYVHLLGDRGSFSDYLIFNPAKNKSIAHMQKFPRGEGALNYNEGKYDDWVLNASFPLVYGTADSVLADYIKKWTPESRILVIGASTQVSNCLIQIAKRHYNIGTVVGICNKNSFEYNEKFGWDHLVSYNDGKTIENVTKLMEEKLGGEKFDMIFDSVGNTDFFPVIDKFLKPKSTGSYFLTVVGDNKLDYKNPTFRRAMPLSVAWKKINPFLGFNYSTVLVKPIDRYMKLSTEMIQKNQFEPVIDSVYEFDQYQEAMDKLLTNKAKGKIVIRVNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ45</accession>
    <name>AIM24_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM24</name>
        <name type="ordered locus">CAGL0M09317g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIM24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ45"/>
    <dbReference type="FunCoup" id="Q6FJ45">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0M09317g-T">
        <property type="protein sequence ID" value="CAGL0M09317g-T-p1"/>
        <property type="gene ID" value="CAGL0M09317g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891313"/>
    <dbReference type="KEGG" id="cgr:2891313"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09317g"/>
    <dbReference type="eggNOG" id="ENOG502RXC5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057912_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ45"/>
    <dbReference type="OMA" id="TINGPRT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000399573" description="Altered inheritance of mitochondria protein 24, mitochondrial">
        <location>
            <begin status="unknown"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="387" mass="42521" checksum="88CCFF295D66ECEA" modified="2004-07-19" version="1" precursor="true">MLKSRFKVVGKEALMASLPLEPSVPMCIRKGCLVSVMAGGAHGSGKTASLVIGHKWVNFWTNLARFRSWNSSLYHVLTTSGKENRALVAPNISRGSPWLSALKLVVSILSKNSKGITITDPQRSIYPLELDGTQDWNVWGRDSLIAFEQNDSLDIKPASLSSSLKRDALFSHSHKYQVVTGRGSVLLGGYGDIYSIDLKNSTDDIVINAQNILAVSGKGQTETMNAIENNPFIISHTAASNIPEFTSNVQELAAFEDPKQQQSQTIVQKTVKEAARASKAVWHWISYVYKKTVIFSNNNGHNITSPAFVKIKGPRTIIIQTSHETTQPVSVSTVDILPRTVENAIPEVVETPKAKSDSYINYATVQPDGNVTFRSVSNFNETIAERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJA7</accession>
    <name>Q6FJA7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M07832g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJA7"/>
    <dbReference type="FunCoup" id="Q6FJA7">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJA7"/>
    <dbReference type="KEGG" id="cgr:2891738"/>
    <dbReference type="CGD" id="CAL0136433">
        <property type="gene designation" value="CAGL0M07832g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07832g"/>
    <dbReference type="eggNOG" id="ENOG502S5X2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_760751_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJA7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015159">
        <property type="entry name" value="Rec107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09074">
        <property type="entry name" value="Mer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="364" mass="41673" checksum="DD975199388A6D69" modified="2004-07-19" version="1">MEQRLETEDLHSESTDISSSIDADDLLHSGDSSLGEADKQIMEWAGKLELESIDLREKSEKLINTLTNMSQELMKVSSQLVKQLENCNHSKEEDIVDQVYKLDVNINNQLQDWKKSFSDQLKSINHNSNLGQIKNLTECMANQEANILGAIRHNSTILKDECRDIIKSQELAGAPKLQRAVDYLHEIMHNMSCQTESMNELLLSIDKQLHNIDLALIKEKDQYKVQFKAFKRSLRDMITSNRNNVEDTVVNTVQVTIERKLEDMFDKMFDQKLLGKLRLLITKGEIPVPEGSKLANAIPLNRHTNDYDLNGTTWTDSSSQDGPRTRARFRTKNKVTKPRKSEISRTIIPWCEISSPPVEYTSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJA9</accession>
    <name>Q6FJA9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M07744g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449685.1">
        <property type="nucleotide sequence ID" value="XM_449685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJA9"/>
    <dbReference type="KEGG" id="cgr:2891735"/>
    <dbReference type="CGD" id="CAL0136211">
        <property type="gene designation" value="CAGL0M07744g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07744g"/>
    <dbReference type="HOGENOM" id="CLU_1184875_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJA9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035179">
        <property type="entry name" value="DUF5314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17241">
        <property type="entry name" value="Retrotran_gag_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0136211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="234" mass="27517" checksum="5470375FA0047140" modified="2004-07-19" version="1">MSLEKKLVYPWVAEIDGSDTSAIFEEIRNPAICEFKTFILSEVGDFQIWIERFEDIILLTNMYWYRFYKAGPYYKEGITDIYERHVISNFDNAMIQLVLKTVSAKVRELCDSYLQFGAHHKQVTVFGLIDQIRSHYDRDNPLITYKRYYAWLGHMSNISNVERELDIRRLITDLLDDMPVMELSDKLSFEEQANKRAEISKYKNDIIAYMTIATTPNITADGITRALREKFGDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJE8</accession>
    <name>SSN8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SSN8</name>
        <name type="ordered locus">CAGL0M06875g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449646.1">
        <property type="nucleotide sequence ID" value="XM_449646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJE8"/>
    <dbReference type="SMR" id="Q6FJE8"/>
    <dbReference type="FunCoup" id="Q6FJE8">
        <property type="interactions" value="1033"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJE8"/>
    <dbReference type="EnsemblFungi" id="CAGL0M06875g-T">
        <property type="protein sequence ID" value="CAGL0M06875g-T-p1"/>
        <property type="gene ID" value="CAGL0M06875g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891695"/>
    <dbReference type="KEGG" id="cgr:2891695"/>
    <dbReference type="CGD" id="CAL0136591">
        <property type="gene designation" value="CAGL0M06875g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M06875g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06875g"/>
    <dbReference type="eggNOG" id="KOG0794">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034754_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FJE8"/>
    <dbReference type="OMA" id="HIIAMAC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990508">
        <property type="term" value="C:CKM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000411">
        <property type="term" value="P:positive regulation of transcription by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000117">
        <property type="entry name" value="Mediator complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000077">
        <property type="entry name" value="RNA polymerase II holoenzyme cyclin-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0195">Cyclin</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000314271" description="RNA polymerase II holoenzyme cyclin-like subunit">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin N-terminal">
        <location>
            <begin position="93"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="339" mass="39489" checksum="E87764C7319927E3" modified="2004-07-19" version="1">MSGSYWTSMQRQKWQHTKPSLARERQRLWVMECQLFPQGLNIIVDSKPNSADSSNGNAANNGGGNGRSQLVATTKNIPITHRDLHYDKDYNLRIYCYFLIMKLGRRLNIRQYALATAHIYLSRFLLKASVREVNLYLLVTTCVYLACKVEECPQYIRTLVSEARSLWPEFIPPDPTKVTEFEFYLIEELQCYLIVHHPYKSMEQIVEALKEEPFKLTFTSDELQNCWSLINDSFINDVHLTYAPHIIAMACLFITVSIQGSNTKELSLTSAVTETLTSQSSLTPQQQTFFRFLAESHVDLEEVMDTIQQQIILYDHWDRYHEPWIKYLLHTLYLRPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJN8</accession>
    <name>Q6FJN8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Transcription regulatory protein SNF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SNF2</name>
        <name evidence="17 18" type="ordered locus">CAGL0M04807g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449556.1">
        <property type="nucleotide sequence ID" value="XM_449556.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FJN8">
        <property type="interactions" value="2142"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJN8"/>
    <dbReference type="GeneID" id="2891566"/>
    <dbReference type="KEGG" id="cgr:2891566"/>
    <dbReference type="CGD" id="CAL0136717">
        <property type="gene designation" value="SNF2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04807g"/>
    <dbReference type="eggNOG" id="KOG0386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_15_1_1"/>
    <dbReference type="InParanoid" id="Q6FJN8"/>
    <dbReference type="OMA" id="NPTRETN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140015">
        <property type="term" value="F:histone H3K14ac reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140008">
        <property type="term" value="F:histone H4 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJX2</accession>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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</entry>
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    <accession>Q6FK29</accession>
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            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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            <title>Genome evolution in yeasts.</title>
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
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                <person name="Ferry-Dumazet H."/>
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                <person name="Jauniaux N."/>
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                <person name="Kerrest A."/>
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                <person name="Lesur I."/>
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                <person name="Nicaud J.M."/>
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                <person name="Richard G.F."/>
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                <person name="Zivanovic I."/>
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                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
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            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
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                <person name="Frangeul L."/>
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                <person name="Barbe V."/>
                <person name="Barnay S."/>
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                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK30"/>
    <dbReference type="FunCoup" id="Q6FK30">
        <property type="interactions" value="2081"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK30"/>
    <dbReference type="KEGG" id="cgr:2891184"/>
    <dbReference type="CGD" id="CAL0136711">
        <property type="gene designation" value="CAGL0M01606g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01606g"/>
    <dbReference type="eggNOG" id="KOG2013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_7_3_1"/>
    <dbReference type="InParanoid" id="Q6FK30"/>
    <dbReference type="OMA" id="PGKTECF"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000004">
        <property type="entry name" value="Ubiquitin-activating enzyme E1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 11 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="17">
        <location>
            <begin position="9"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="18">
        <location>
            <begin position="299"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="558"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12 15">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0136711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG62390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="632" mass="71152" checksum="D44E20EA34DD07E7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK83</accession>
    <name>Q6FK83_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Sulfite reductase [NADPH] subunit beta</fullName>
            <ecNumber evidence="6">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21" type="ordered locus">CAGL0M00374g</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the reduction of sulfite to sulfide, one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Alpha(2)-beta(2). The alpha component is a flavoprotein, the beta component is a hemoprotein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="6"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FK83">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK83"/>
    <dbReference type="KEGG" id="cgr:2891141"/>
    <dbReference type="CGD" id="CAL0136853">
        <property type="gene designation" value="CAGL0M00374g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00374g"/>
    <dbReference type="eggNOG" id="KOG0560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001975_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FK83"/>
    <dbReference type="OMA" id="CSRPWLA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009337">
        <property type="term" value="C:sulfite reductase complex (NADPH)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050311">
        <property type="term" value="F:sulfite reductase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000097">
        <property type="term" value="P:sulfur amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000003">
        <property type="entry name" value="Sulfite reductase [NADPH] hemoprotein beta-component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000051">
        <property type="entry name" value="Sulfite reductase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000016">
        <property type="entry name" value="Sulfite reductase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010029">
        <property type="entry name" value="PRK13504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493:SF47">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="19">
        <location>
            <begin position="642"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0136853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG62337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1402" mass="157273" checksum="AA8C4A2FD37BA0AB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK86</accession>
    <name>Q6FK86_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M00308g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449358.1">
        <property type="nucleotide sequence ID" value="XM_449358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK86"/>
    <dbReference type="KEGG" id="cgr:2891144"/>
    <dbReference type="CGD" id="CAL0136469">
        <property type="gene designation" value="CAGL0M00308g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00308g"/>
    <dbReference type="HOGENOM" id="CLU_2249797_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK86"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0136469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="104" mass="11832" checksum="8AC4D0BE918F4C50" modified="2004-07-19" version="1">MSTKPIVNEFERTEVRDEITLERDERPGEKSFVIGLTPRSLFSHCVKFHALLATFSSMCDIPITFSAANLEIQLSSSPQQTVNYKPNALKSKNQLPKTHLWLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK92</accession>
    <name>Q6FK92_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="16">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BAT2</name>
        <name evidence="17 18" type="ordered locus">CAGL0M00176g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-oxocarboxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:31763"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:31765"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 6/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="16"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449352.1">
        <property type="nucleotide sequence ID" value="XM_449352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK92"/>
    <dbReference type="STRING" id="284593.Q6FK92"/>
    <dbReference type="GeneID" id="2891150"/>
    <dbReference type="KEGG" id="cgr:2891150"/>
    <dbReference type="CGD" id="CAL0137043">
        <property type="gene designation" value="BAT2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00176g"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FK92"/>
    <dbReference type="OMA" id="WLGLTQC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010326">
        <property type="term" value="F:methionine-oxo-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 16" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10 16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0137043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG62328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="371" mass="41577" checksum="31440A536670222C" modified="2004-07-19" version="1">MDASRLKITKVSTPSERKPNDQLVFGKTFTDHMLTIEWTSENGWDAPEIKPYGKLCLDPSSIVFHYAFELFEGMKAYRTKDGKIAMFRPEKNMERMNKSAARICLPTFDGEELIKLIGKLIELDKHLIPEGEGYSLYIRPTLIGTSEGLGVKEPDRALLFVICSPVGPYYKTGFKAVRLDATDYATRAWPGGVGDKKLGANYAPCVLPQTQAAAKGFQQNLWLFGPEHYVTEVGTMNAFFAFNCKETGKKELVTAPLDGTILEGVTRDSILTLARKYLDPNEWEINERYFTIHEVQEKAHKGELLEAFGSGTAAIVSPIKEIGWKDTIINVPLIPGEQSGPLTKQIASWMMDIQYGKVELDNWLRIVADIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKN2</accession>
    <name>Q6FKN2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAGL0L10208g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKN2"/>
    <dbReference type="FunCoup" id="Q6FKN2">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKN2"/>
    <dbReference type="KEGG" id="cgr:2891062"/>
    <dbReference type="eggNOG" id="KOG0672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014402_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKN2"/>
    <dbReference type="OMA" id="WNPSYPI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF17">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE SUBUNIT SIS2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="242"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="571" mass="62117" checksum="CD56BEDE5ECAEECE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLH9</accession>
    <name>Q6FLH9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0L03289g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUN family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLH9"/>
    <dbReference type="FunCoup" id="Q6FLH9">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLH9"/>
    <dbReference type="CAZy" id="GH132">
        <property type="family name" value="Glycoside Hydrolase Family 132"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890726"/>
    <dbReference type="CGD" id="CAL0135920">
        <property type="gene designation" value="CAGL0L03289g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03289g"/>
    <dbReference type="eggNOG" id="ENOG502QREM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033459_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLH9"/>
    <dbReference type="OMA" id="CIWGTEG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051526">
        <property type="entry name" value="Beta-Glucosidase_SUN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005556">
        <property type="entry name" value="SUN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31316:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE-LIKE PROTEIN NCA3, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03856">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012474981" evidence="5">
        <location>
            <begin position="16"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0135920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="366" mass="37820" checksum="8726713B6A7F511D" modified="2004-07-19" version="1">MKFVSAILMASAVLAAPAVQHQDKHAHEKRDLVVVTEYVDQDGNIFTPTEVVNDAPAATPTPAPAAAPSSAAPAAPAASPAKDTTTLAPSSSKQQASQPTTGSSFTGGAFQDGTIPCSQFPSGNGVVALDWLNMGGWASIMDLNGNTASSCQEGFYCSYACESGMSKTQWPSNQPADGRSVGGLYCKGGFLYRANTNANTLCEQDAGTAFAENQVGQSIAICRTDYPGSENMVIPTVVGAGSTQPISVVKEDSYYQWKGMKTSAQFYVNNAGVSVENGCIWGNEGSGVGNWAPVVLGAGETNGITYLSIIPNPNNRTPPNFNVKIVATDGSSVNGACKYENGVYSGSGSDGCTVSVTSGSAKFVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM08</accession>
    <name>Q6FM08_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0K11990g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448736.1">
        <property type="nucleotide sequence ID" value="XM_448736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM08"/>
    <dbReference type="STRING" id="284593.Q6FM08"/>
    <dbReference type="KEGG" id="cgr:2889964"/>
    <dbReference type="CGD" id="CAL0134673">
        <property type="gene designation" value="CAGL0K11990g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11990g"/>
    <dbReference type="eggNOG" id="KOG1989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005611_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM08"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF65">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE AKL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="109"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="930"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="952"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0134673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="991" mass="111667" checksum="15984A5C0DD904AD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMI5</accession>
    <name>LYS2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>L-2-aminoadipate reductase large subunit</fullName>
            <ecNumber evidence="2">1.2.1.31</ecNumber>
            <ecNumber evidence="2">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Alpha-aminoadipate reductase</fullName>
            <shortName>Alpha-AR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">LYS2</name>
        <name type="ordered locus">CAGL0K07788g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
        <text evidence="2">Binds 1 phosphopantetheine covalently.</text>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="2"/>
    <dbReference type="EC" id="1.2.1.95" evidence="2"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448559.1">
        <property type="nucleotide sequence ID" value="XM_448559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMI5"/>
    <dbReference type="SMR" id="Q6FMI5"/>
    <dbReference type="FunCoup" id="Q6FMI5">
        <property type="interactions" value="769"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMI5"/>
    <dbReference type="EnsemblFungi" id="CAGL0K07788g-T">
        <property type="protein sequence ID" value="CAGL0K07788g-T-p1"/>
        <property type="gene ID" value="CAGL0K07788g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890361"/>
    <dbReference type="KEGG" id="cgr:2890361"/>
    <dbReference type="CGD" id="CAL0133971">
        <property type="gene designation" value="CAGL0K07788g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07788g"/>
    <dbReference type="eggNOG" id="KOG1178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_19_1_1"/>
    <dbReference type="InParanoid" id="Q6FMI5"/>
    <dbReference type="OMA" id="ENDKFTM"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd17647">
        <property type="entry name" value="A_NRPS_alphaAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000046">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000193150" description="L-2-aminoadipate reductase large subunit">
        <location>
            <begin position="1"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="828"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P07702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1374" mass="152537" checksum="FF8BF53926B4B184" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FML7</accession>
    <name>ERT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ERT1</name>
        <name type="ordered locus">CAGL0K06985g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERT1/acuK family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448527.1">
        <property type="nucleotide sequence ID" value="XM_448527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FML7"/>
    <dbReference type="SMR" id="Q6FML7"/>
    <dbReference type="FunCoup" id="Q6FML7">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0K06985g-T">
        <property type="protein sequence ID" value="CAGL0K06985g-T-p1"/>
        <property type="gene ID" value="CAGL0K06985g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890386"/>
    <dbReference type="KEGG" id="cgr:2890386"/>
    <dbReference type="CGD" id="CAL0133843">
        <property type="gene designation" value="CAGL0K06985g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06985g"/>
    <dbReference type="eggNOG" id="ENOG502R1M5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010748_2_3_1"/>
    <dbReference type="InParanoid" id="Q6FML7"/>
    <dbReference type="OMA" id="VMTTCKL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045991">
        <property type="term" value="P:carbon catabolite activation of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF1">
        <property type="entry name" value="TRANSCRIPTION ACTIVATOR OF GLUCONEOGENESIS ERT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000406459" description="Transcription activator of gluconeogenesis ERT1">
        <location>
            <begin position="1"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="476"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="596" mass="68233" checksum="468D75FA122CA0DF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMN4</accession>
    <name>Q6FMN4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K06589g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMN4"/>
    <dbReference type="FunCoup" id="Q6FMN4">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMN4"/>
    <dbReference type="KEGG" id="cgr:2890442"/>
    <dbReference type="CGD" id="CAL0133873">
        <property type="gene designation" value="CAGL0K06589g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06589g"/>
    <dbReference type="eggNOG" id="KOG3315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073154_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FMN4"/>
    <dbReference type="OMA" id="YMVKFDD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0133873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="221" mass="25181" checksum="486F8525B391C687" modified="2004-07-19" version="1">MNTIYNESLIFKKKEVSLSAMTFLYQEMISNIHNDCKDINEFETRLSKMGYNIGLRLIELLNFRASATFTSKNFLSSGSNTSNGSSDATITASDQESSLTSFINRMRRRDLKILDVLQFIHGSLWSYLFGHVSNDLVKSSERENEYMIVDNKPKLTQFISGKNVSCDYFVCGIIHGYLTSAGFPCKVTPHSMPQDGHDNRVVFLIQFDKQVLEREGLRISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMQ7</accession>
    <name>Q6FMQ7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K06083g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448487.1">
        <property type="nucleotide sequence ID" value="XM_448487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMQ7"/>
    <dbReference type="KEGG" id="cgr:2890452"/>
    <dbReference type="CGD" id="CAL0133997">
        <property type="gene designation" value="CAGL0K06083g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06083g"/>
    <dbReference type="HOGENOM" id="CLU_885653_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMQ7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="314" mass="35878" checksum="1FE59074E7C3F088" modified="2004-07-19" version="1">MVNAWKVGEIDGRYNLLKQDIDRDGTKLLKITIHMTEALLVPQSSTLKKSLKTYAVKLDSARKQLKSQGFDLQSSDNLIKIVIEFLNNLNCYTKNNYKDSKCEMSLHKSDMKITIKLDATIKATINLGFVRLTDEQGLLILLELSHFLSETLWYWSRVCSLIDSESNTKNLNNCLIELNRIAEAKESNQIYGRDLAKLFIIREKLLGRQAKLSGMISTRSSKSDELPGEFSEFDSDDMSWRTNSVTPIEILRSEDINELSSQTDKIPAKRVRKEDSIKMESRILDSNYEEAAISESPKRKKKKFGKIVVSPTKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN18</accession>
    <name>MYO5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Myosin-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Class I unconventional myosin MYO5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Type I myosin MYO5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MYO5</name>
        <name type="ordered locus">CAGL0K03487g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The tail domain participates in molecular interactions that specify the role of the motor domain (By similarity). It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylation of the TEDS site (Ser-358) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448376.1">
        <property type="nucleotide sequence ID" value="XM_448376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN18"/>
    <dbReference type="SMR" id="Q6FN18"/>
    <dbReference type="FunCoup" id="Q6FN18">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN18"/>
    <dbReference type="EnsemblFungi" id="CAGL0K03487g-T">
        <property type="protein sequence ID" value="CAGL0K03487g-T-p1"/>
        <property type="gene ID" value="CAGL0K03487g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890177"/>
    <dbReference type="KEGG" id="cgr:2890177"/>
    <dbReference type="CGD" id="CAL0134571">
        <property type="gene designation" value="CAGL0K03487g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03487g"/>
    <dbReference type="eggNOG" id="KOG0162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_7_6_1"/>
    <dbReference type="InParanoid" id="Q6FN18"/>
    <dbReference type="OMA" id="NDQENQC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007121">
        <property type="term" value="P:bipolar cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0505">Motor protein</keyword>
    <keyword id="KW-0518">Myosin</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0728">SH3 domain</keyword>
    <feature type="chain" id="PRO_0000338545" description="Myosin-5">
        <location>
            <begin position="1"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="4">
        <location>
            <begin position="37"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="IQ 1">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="IQ 2">
        <location>
            <begin position="741"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="5">
        <location>
            <begin position="772"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="1">
        <location>
            <begin position="405"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="956"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1145"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1197"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="976"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="994"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1025"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1072"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1162"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1203"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="130"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="1217" mass="135835" checksum="DF5566948B4E9626" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN30</accession>
    <name>Q6FN30_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0K03201g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN30"/>
    <dbReference type="FunCoup" id="Q6FN30">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN30"/>
    <dbReference type="KEGG" id="cgr:2890226"/>
    <dbReference type="CGD" id="CAL0134869">
        <property type="gene designation" value="CAGL0K03201g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03201g"/>
    <dbReference type="eggNOG" id="KOG4073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081974_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FN30"/>
    <dbReference type="OMA" id="GWTVANS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00488">
        <property type="entry name" value="PCD_DCoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0134869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="108" mass="12518" checksum="5348A33AC9F98BFF" modified="2004-07-19" version="1">MFNKIVKSEAERVSAADLQKALKQLKGWTHDNSRLVREVAFKDYQLTWAFLTQVAMRSHLWGHHPLITTSYTSVRLELQTHDLEMSPGVSNIDVKLAKQIEKYISQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN46</accession>
    <name>Q6FN46_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAGL0K02827g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN46"/>
    <dbReference type="FunCoup" id="Q6FN46">
        <property type="interactions" value="797"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN46"/>
    <dbReference type="KEGG" id="cgr:2890273"/>
    <dbReference type="eggNOG" id="KOG3230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069208_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FN46"/>
    <dbReference type="OMA" id="KMAKMNQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="153" mass="16982" checksum="2DBA4F1438A62807" modified="2004-07-19" version="1">MKAQLQAISLRIQAVRSSDQMTRSMREATGLLAGMNRSMNLPQLQKISMEFEKQSDLMDQRQEFMDEAIDNVMGDELEENEDADEIVNKVLDEIGIDLNSQLQNTPQHELKLPGEAESQNGVAETVGASGSGGDTKMSPDDDLQARLDSLKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN59</accession>
    <name>Q6FN59_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0K02519g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ISF1/MBR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448335.1">
        <property type="nucleotide sequence ID" value="XM_448335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN59"/>
    <dbReference type="FunCoup" id="Q6FN59">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890312"/>
    <dbReference type="CGD" id="CAL0134051">
        <property type="gene designation" value="CAGL0K02519g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02519g"/>
    <dbReference type="HOGENOM" id="CLU_1288749_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN59"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031443">
        <property type="entry name" value="Mbr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17058">
        <property type="entry name" value="MBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="71"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0134051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="214" mass="24000" checksum="CA5FC40D39272D3A" modified="2004-07-19" version="1">MQVGLENIFERSVQDPCCLIEDEMDTYTEFPKYDYSHCQAGQDELHGYTSLRKYNSVPSIPLQHNTQHIIPVSPTQARDHTTRRRSSLYSADPSHTCRRSHSNANILCTPTQNRSKRNSLCSPHSSRPQEGPMRSRSQSVVAIPSHLLSIEKYITSELDTNISPTINPSTKANPPFLSSQSSSDSGSYTSDYTRPPTTRRRSSFKVSLASSFSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN65</accession>
    <name>ROK1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase ROK1</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ROK1</name>
        <name type="ordered locus">CAGL0K02387g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text>ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448329.1">
        <property type="nucleotide sequence ID" value="XM_448329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN65"/>
    <dbReference type="SMR" id="Q6FN65"/>
    <dbReference type="FunCoup" id="Q6FN65">
        <property type="interactions" value="1120"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN65"/>
    <dbReference type="EnsemblFungi" id="CAGL0K02387g-T">
        <property type="protein sequence ID" value="CAGL0K02387g-T-p1"/>
        <property type="gene ID" value="CAGL0K02387g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890306"/>
    <dbReference type="KEGG" id="cgr:2890306"/>
    <dbReference type="CGD" id="CAL0134695">
        <property type="gene designation" value="CAGL0K02387g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02387g"/>
    <dbReference type="eggNOG" id="KOG0344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_4_1"/>
    <dbReference type="InParanoid" id="Q6FN65"/>
    <dbReference type="OMA" id="EMAHSIM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000759">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232301" description="ATP-dependent RNA helicase ROK1">
        <location>
            <begin position="1"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="155"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="346"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="124"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="282"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="168"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="565" mass="63742" checksum="B59AD0ED4816689C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN97</accession>
    <name>Q6FN97_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0K01661g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN97"/>
    <dbReference type="FunCoup" id="Q6FN97">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN97"/>
    <dbReference type="KEGG" id="cgr:2890023"/>
    <dbReference type="CGD" id="CAL0133837">
        <property type="gene designation" value="CAGL0K01661g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01661g"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_82_3_1"/>
    <dbReference type="InParanoid" id="Q6FN97"/>
    <dbReference type="OMA" id="NEDATHI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF515">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RTK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="179"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0133837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG61258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="482" mass="54965" checksum="FE54145A1D86C210" modified="2004-07-19" version="1">MVSFINGTDRLPGSSSSSSLSGRKSSLRKLFFRSSDEIPSIAPKSSSIHLNPTTSTPVSSEHRPFPHNLHSPLNYTTRQLSQRHTSSASQLEMLHPVEALMHRKLPETWPDIPTVHEPQEKKKQPPLKRFLKKFNSSSNSSSTDDSYNASSSMVTPVTYKQTVLTDYVDTPMELIHKYGIPGKKIGEGASGSVSIVKKSNGQQYAVKMFRTSPNSTQEQIEKYCKKITAEFCMGSTLHHANVIETFDIIREGNSLLMVMEYAPYDFFDLVMTNTMSPDEISCYFKQLCHGVNYLHAMGIAHRDLKLDNCVVTNDGILKLIDFGSAVIFQYPYERNIVKATGIVGSDPYLSPELLEMNHYDPRLADVWSLAIIYYCMTLKRFPWKAPRKQFNSFRLFCEDPDDENDFSKGPMKVLRQLPSYSRDLIGKMLELEVKDRYYLEQVMKHEWFQSIEVCIADSKGELLYKPKTHIHHLETELKVSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNB2</accession>
    <name>Q6FNB2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0K01331g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNB2"/>
    <dbReference type="FunCoup" id="Q6FNB2">
        <property type="interactions" value="1023"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNB2"/>
    <dbReference type="KEGG" id="cgr:2890052"/>
    <dbReference type="CGD" id="CAL0133867">
        <property type="gene designation" value="CAGL0K01331g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01331g"/>
    <dbReference type="eggNOG" id="KOG0373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="InParanoid" id="Q6FNB2"/>
    <dbReference type="OMA" id="MCLKVKY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="116"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0133867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="325" mass="36812" checksum="81B70790888BFAEE" modified="2004-07-19" version="1">MDTASNRRGPDEWLETVKKCQALTENEMKQLCEMVKELLMEESNIQPVMTPVTVCGDIHGQFHDLLELFRTSGGFPDDDVNYIFLGDYVDRGYYSLETFTLLMCLKVKYPAKITLVRGNHESRQITQVYGFYEECLNKYGSTTVWKYCCQVFDFLTLAAIIDGKILCVHGGLSPEIRMLDQIRVLSRAQEVPHEGGFSDLLWSDPDNVEAWQVSPRGAGWLFGSKVAREFNHVNGLNLIARAHQLVMEGFKYHFPEKDVVTVWSAPNYCYRCGNVASVMKVDEDLEPTFKIFSAVPDDYINQDASSPTTNNGNSGSNSQRAGYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNE4</accession>
    <name>Q6FNE4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell division control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0K00605g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDC6/cdc18 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG61211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNE4"/>
    <dbReference type="KEGG" id="cgr:2890231"/>
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        <property type="gene designation" value="CAGL0K00605g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00605g"/>
    <dbReference type="eggNOG" id="KOG2227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012774_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FNE4"/>
    <dbReference type="OMA" id="WPTDEVY"/>
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        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:nuclear pre-replicative complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140530">
        <property type="term" value="P:MCM complex loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016314">
        <property type="entry name" value="Cdc6/18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="WHD_Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001767">
        <property type="entry name" value="Cdc6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="117"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6 C-terminal" evidence="9">
        <location>
            <begin position="424"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001767"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0134181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="523" mass="58802" checksum="3E94693F4E0DD4CF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNN0</accession>
    <name>Q6FNN0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J10406g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNN0"/>
    <dbReference type="FunCoup" id="Q6FNN0">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNN0"/>
    <dbReference type="KEGG" id="cgr:2889602"/>
    <dbReference type="CGD" id="CAL0129699">
        <property type="gene designation" value="CAGL0J10406g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10406g"/>
    <dbReference type="eggNOG" id="KOG2241">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_6_6_1"/>
    <dbReference type="InParanoid" id="Q6FNN0"/>
    <dbReference type="OMA" id="QVCRTVC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006418">
        <property type="term" value="P:tRNA aminoacylation for protein translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10304">
        <property type="entry name" value="GST_C_Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000199">
        <property type="entry name" value="tRNA-aminoacylation cofactor ARC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="5">
        <location>
            <begin position="204"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="134"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0129699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="376" mass="42160" checksum="505563121E03FD59" modified="2004-07-19" version="1">MSDLVAKFKGLSVADSTAQLSREQSALVAQWESILKTGQLQANLNNLNLQLRDNSFIAATSQPTVHDVELFEATLPVIKELVSSSKDIKGTLGSYRHIIRWVDYLQALLQLSKDQTLEFDRNIELPREVIEKPKKKDDAKKDDGKKDDKKDDKKKANDGDKKQRGKPDEETLKKLREEAKAKKAAKKAAQAQQQKETKAPEKVLPSVIDFRVGFIQKAIKHPDADSLYVSTIDVGDEEGPRTVCSGLVKHFPLEAMQERYVVAVCNLKPVNMRGVKSTAMVLCGSNAEDKVEFVEPPKGSKAGDKVFFEGFGAEDPLKQLNPKKKLWEQLQPHFSTNENLEVIFKDEEDKEHPVRKLTNAKGEEFKVATIVNANVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNP8</accession>
    <name>Q6FNP8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleolar protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0J10032g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNP8"/>
    <dbReference type="SMR" id="Q6FNP8"/>
    <dbReference type="FunCoup" id="Q6FNP8">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNP8"/>
    <dbReference type="KEGG" id="cgr:2889431"/>
    <dbReference type="CGD" id="CAL0133608">
        <property type="gene designation" value="CAGL0J10032g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10032g"/>
    <dbReference type="eggNOG" id="KOG1122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FNP8"/>
    <dbReference type="OMA" id="PIGSWTK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000192">
        <property type="entry name" value="NOP2p rRNA m5C methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="264"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="481"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="356"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0133608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG61097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="619" mass="69875" checksum="255732D1A7503205" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-02-28" modified="2025-06-18" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNQ2</accession>
    <name>AQR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multidrug transporter AQR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Drug:H(+) antiporter AQR1</fullName>
            <shortName evidence="7">DHA AQR1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Flucytosine exporter AQR1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">AQR1</name>
        <name type="ordered locus">CAGL0J09944g</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2013" name="Front. Microbiol." volume="4" first="170" last="170">
            <title>The dual role of candida glabrata drug:H+ antiporter CgAqr1 (ORF CAGL0J09944g) in antifungal drug and acetic acid resistance.</title>
            <authorList>
                <person name="Costa C."/>
                <person name="Henriques A."/>
                <person name="Pires C."/>
                <person name="Nunes J."/>
                <person name="Ohno M."/>
                <person name="Chibana H."/>
                <person name="Sa-Correia I."/>
                <person name="Teixeira M.C."/>
            </authorList>
            <dbReference type="PubMed" id="23805133"/>
            <dbReference type="DOI" id="10.3389/fmicb.2013.00170"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="526" last="526">
            <title>Clotrimazole drug resistance in Candida glabrata clinical isolates correlates with increased expression of the drug:H(+) antiporters CgAqr1, CgTpo1_1, CgTpo3, and CgQdr2.</title>
            <authorList>
                <person name="Costa C."/>
                <person name="Ribeiro J."/>
                <person name="Miranda I.M."/>
                <person name="Silva-Dias A."/>
                <person name="Cavalheiro M."/>
                <person name="Costa-de-Oliveira S."/>
                <person name="Rodrigues A.G."/>
                <person name="Teixeira M.C."/>
            </authorList>
            <dbReference type="PubMed" id="27148215"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.00526"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Multidrug transporter acts as a determinant of resistance to acetic acid, flucytosine and clotrimazole, these 3 compounds acting synergistically against the pathogen (PubMed:23805133, PubMed:27148215). Reduces the intracellular accumulation of the antifungal agents flucytosine and, to a moderate extent, of clotrimazole (PubMed:23805133). Its role in acetic acid resistance may be indirect, presumably through the transport of a still unidentified physiological substrate (PubMed:23805133).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="4">Also localizes to membrane vesicles (PubMed:23805133).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to intracellular accumulation of flucytosine and clotrimazole (PubMed:23805133).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. CAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448142.1">
        <property type="nucleotide sequence ID" value="XM_448142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNQ2"/>
    <dbReference type="FunCoup" id="Q6FNQ2">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNQ2"/>
    <dbReference type="GlyCosmos" id="Q6FNQ2">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0J09944g-T">
        <property type="protein sequence ID" value="CAGL0J09944g-T-p1"/>
        <property type="gene ID" value="CAGL0J09944g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889427"/>
    <dbReference type="KEGG" id="cgr:2889427"/>
    <dbReference type="CGD" id="CAL0133042">
        <property type="gene designation" value="AQR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09944g"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_8_4_1"/>
    <dbReference type="InParanoid" id="Q6FNQ2"/>
    <dbReference type="OMA" id="MCGFWSS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015565">
        <property type="term" value="F:threonine efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032973">
        <property type="term" value="P:amino acid export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071311">
        <property type="term" value="P:cellular response to acetate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000443409" description="Multidrug transporter AQR1">
        <location>
            <begin position="1"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="23805133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="27148215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="23805133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="27148215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="592" mass="64860" checksum="A4E401059A4622F3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNT1</accession>
    <name>Q6FNT1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J09284g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448113.1">
        <property type="nucleotide sequence ID" value="XM_448113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNT1"/>
    <dbReference type="FunCoup" id="Q6FNT1">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889951"/>
    <dbReference type="CGD" id="CAL0133212">
        <property type="gene designation" value="CAGL0J09284g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09284g"/>
    <dbReference type="eggNOG" id="ENOG502S5IG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091460_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNT1"/>
    <dbReference type="OMA" id="EYVRVFH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="221" mass="25258" checksum="6EDC531CBF2237F1" modified="2004-07-19" version="1">MSESSKFRPPIAETKKLESDILAIIQRLRDDEAGEGQVAKDEVISVLNRSLTALSHWVLQAQLMELDPNNQDRVAVENSLLKKEVEFLSGKASQKRLHPIQIPPSQLKEPSERPYKVDVHTPVKEKRKKKIDISQITPKRGEFSPKQQNTGTKYDAEKSPTGRSLNTRRTSGEPLSPKGLHEPGTQFKLVENKKPHPRMRRTSDNPSRNEYVRVFHLEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNX5</accession>
    <name>Q6FNX5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0J08294g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNX5"/>
    <dbReference type="FunCoup" id="Q6FNX5">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNX5"/>
    <dbReference type="KEGG" id="cgr:2889926"/>
    <dbReference type="CGD" id="CAL0133176">
        <property type="gene designation" value="CAGL0J08294g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08294g"/>
    <dbReference type="eggNOG" id="KOG1172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002289_7_2_1"/>
    <dbReference type="InParanoid" id="Q6FNX5"/>
    <dbReference type="OMA" id="RRAPFYW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="71"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="244"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0133176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="597" mass="67076" checksum="B1094A5CF939F052" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNX9</accession>
    <name>Q6FNX9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein BNI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0J08206g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FNX9">
        <property type="interactions" value="561"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNX9"/>
    <dbReference type="KEGG" id="cgr:2889922"/>
    <dbReference type="CGD" id="CAL0132946">
        <property type="gene designation" value="CAGL0J08206g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08206g"/>
    <dbReference type="eggNOG" id="KOG1922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001313_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FNX9"/>
    <dbReference type="OMA" id="NHYWKAR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="term" value="P:barbed-end actin filament capping"/>
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        <property type="term" value="P:establishment of mitotic spindle orientation"/>
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        <property type="term" value="P:formin-nucleated actin cable assembly"/>
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        <property type="term" value="P:regulation of protein localization"/>
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        <property type="entry name" value="Cytokinesis protein sepA"/>
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        <property type="entry name" value="Cytokinesis sepA protein"/>
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        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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        <property type="entry name" value="PROTEIN BNI1"/>
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        <property type="entry name" value="GBD_FH3"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="176"/>
            <end position="684"/>
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            <begin position="1255"/>
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            <begin position="1702"/>
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            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
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            <begin position="232"/>
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            <begin position="1004"/>
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            <begin position="1837"/>
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            <begin position="704"/>
            <end position="781"/>
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    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="898"/>
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            <begin position="1"/>
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            <dbReference type="ARBA" id="ARBA00037935"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS51231"/>
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        <source>
            <dbReference type="EMBL" id="CAG61016.1"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1898" mass="214453" checksum="250DB0E399332969" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP05</accession>
    <name>ATG2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATG2</name>
        <name type="ordered locus">CAGL0J07634g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an ATG18-PtdIns3P interaction. ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448039.1">
        <property type="nucleotide sequence ID" value="XM_448039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP05"/>
    <dbReference type="FunCoup" id="Q6FP05">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP05"/>
    <dbReference type="EnsemblFungi" id="CAGL0J07634g-T">
        <property type="protein sequence ID" value="CAGL0J07634g-T-p1"/>
        <property type="gene ID" value="CAGL0J07634g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889899"/>
    <dbReference type="KEGG" id="cgr:2889899"/>
    <dbReference type="CGD" id="CAL0133478">
        <property type="gene designation" value="SPO72"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07634g"/>
    <dbReference type="eggNOG" id="KOG2993">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000626_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FP05"/>
    <dbReference type="OMA" id="YDWKYTR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097632">
        <property type="term" value="C:extrinsic component of phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
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            <end position="1587"/>
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        <location>
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            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O94649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P53855"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1587" mass="179236" checksum="6EED9DB8034333FB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP32</accession>
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            <fullName evidence="11">Glycerophosphodiester phosphodiesterase GDE1</fullName>
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        <name evidence="8 9" type="ordered locus">CAGL0J07040g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
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                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
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                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
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                <person name="Potier S."/>
                <person name="Richard G.F."/>
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                <person name="Zivanovic I."/>
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                <person name="Scarpelli C."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANK"/>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51704"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0132944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1245" mass="140102" checksum="6F4F75D439E4B7FA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP84</accession>
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        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
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        <name evidence="4 5" type="ordered locus">CAGL0J05852g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
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                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
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                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
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    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0133742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37698" checksum="081E3DE3A4683CE6" modified="2004-07-19" version="1">MPAPTQPAPSYSKCYALKEIIYGFWATKVTYTPDKYPDLTGKTAVVTGCNTGVGKEAAKLLYQKNCNVIGVCRTESKGLEAAESIKQEIGNSKGSISVVSGCDFLDFTTVPQAGKRIQEILAGKPLNIIIHNAGLMSSSNAGTSKQGLEAMFQTNVMGPQLLQHYLDPVFLKEDDTSLKRIVWVSSGAHLLGPSQYGIFWENPGFDGVAIEKRPAATTLYGATKAANILQAKAWATRNKEMVDKIGCVSVSCYPGNLRTDLQRDWHPWTRATVGRLFYPAEYGAYTELYSVLSPSLTTSDQGKYICPFDQVHEPREDVKEGLQNGTDLALWDWIESEIKEYIS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPI4</accession>
    <name>RAD18_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Postreplication repair E3 ubiquitin-protein ligase RAD18</fullName>
            <ecNumber evidence="1">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase RAD18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RAD18</name>
        <name type="ordered locus">CAGL0J03586g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with the E2 ubiquitin conjugating enzyme UBC2, monoubiquitinates PCNA to promote two parallel branches of the DNA damage tolerance (DDT) pathway (also known as the post-replication repair (PRR) pathway) that bypasses replication-blocking lesions without removing them; monoubiquitination promotes the translesion synthesis (TLS) pathway and leads to the recruitment of translesion polymerases for lesion bypass, whereas further polyubiquitination of PCNA promotes template-switching (TS) to the newly synthesized sister chromatid for synthesis past the lesion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RAD18 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="1"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447860.1">
        <property type="nucleotide sequence ID" value="XM_447860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPI4"/>
    <dbReference type="SMR" id="Q6FPI4"/>
    <dbReference type="FunCoup" id="Q6FPI4">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPI4"/>
    <dbReference type="EnsemblFungi" id="CAGL0J03586g-T">
        <property type="protein sequence ID" value="CAGL0J03586g-T-p1"/>
        <property type="gene ID" value="CAGL0J03586g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889701"/>
    <dbReference type="KEGG" id="cgr:2889701"/>
    <dbReference type="CGD" id="CAL0133446">
        <property type="gene designation" value="CAGL0J03586g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03586g"/>
    <dbReference type="eggNOG" id="KOG0287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028491_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FPI4"/>
    <dbReference type="OMA" id="IPNTGPR"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097505">
        <property type="term" value="C:Rad6-Rad18 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042275">
        <property type="term" value="P:error-free postreplication DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000172">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004580">
        <property type="entry name" value="Rad18_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00599">
        <property type="entry name" value="rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000056154" description="Postreplication repair E3 ubiquitin-protein ligase RAD18">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="3">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBZ4-type" evidence="4">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P10862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="411" mass="46771" checksum="7F1772CE58665798" modified="2004-07-19" version="1">MDVLTSAADFKKSKVPQLQELDDLLRCHICKDFLKNPVLTPCGHTFCSLCIRGYLSNEPKCPLCLHELRESMLRSEYLVNEITETYKAARQRLLDELNSLETNQDNSVIEVVSDKEPSLLQIDDDVNENSNHITVNDTSDIIDEDNEIQITGTKRTARTILNGSRPTKAAKISDMFTTRKAKTEEKAPCPICSQLFPIRYLERTHLDECLTKPPTSSPPIKQSRLSPKPSESVSHVKRYLNSTNTSTQQRLPKLNFAKMTTSQLKQKLASLSLPVSGTRANMVARYNYYEMLWNSNFIDSINPVSESELRRQLMSWDASHNGNNNSSNGGTNTISQLMKMNSKNKGKEYEKLLKDFKKDSFDKKGWMLLHKNSFNRLLCDAKKTRRKTENETLMTSQSPRESSTQTELSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPK2</accession>
    <name>Q6FPK2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J03168g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPK2"/>
    <dbReference type="FunCoup" id="Q6FPK2">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPK2"/>
    <dbReference type="KEGG" id="cgr:2889729"/>
    <dbReference type="CGD" id="CAL0133426">
        <property type="gene designation" value="CAGL0J03168g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03168g"/>
    <dbReference type="eggNOG" id="KOG2286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011776_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FPK2"/>
    <dbReference type="OMA" id="MNIGPKT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035544">
        <property type="term" value="P:negative regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0133426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="813" mass="94592" checksum="495D8FB2E0A84491" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPN7</accession>
    <name>RL2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein uL2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPL2</name>
        <name type="ordered locus">CAGL0J02354g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPN7"/>
    <dbReference type="SMR" id="Q6FPN7"/>
    <dbReference type="FunCoup" id="Q6FPN7">
        <property type="interactions" value="1376"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPN7"/>
    <dbReference type="EnsemblFungi" id="CAGL0J02354g-T">
        <property type="protein sequence ID" value="CAGL0J02354g-T-p1"/>
        <property type="gene ID" value="CAGL0J02354g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889760"/>
    <dbReference type="CGD" id="CAL0133490">
        <property type="gene designation" value="CAGL0J02354g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J02354g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02354g"/>
    <dbReference type="eggNOG" id="KOG2309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_0_3_1"/>
    <dbReference type="InParanoid" id="Q6FPN7"/>
    <dbReference type="OMA" id="HPYKFKM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000129759" description="Large ribosomal subunit protein uL2">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="254" mass="27338" checksum="088D2FCFC9195CA3" modified="2004-07-19" version="1">MGRVIRNQRKGAGSIFTSHTRLRQGAAKLRTLDYAERHGYIRGVVKQIVHDAGRGAPLAKVVFRDPYKYKLREEIFIANEGVHTGQFIYAGKKASLNVGNVLPLGSVPEGTIVSNVEEKPGDRGALARASGNYVIIIGHNPDENKTRVRLPSGAKKIISSDARGVIGVIAGGGRTDKPLLKAGRAFHKYKLKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRGAVSGQKAGLIAARRTGLLRGSQKTQD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-23" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ21</accession>
    <name>NOP58_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NOP58</name>
        <name type="ordered locus">CAGL0I09790g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447673.1">
        <property type="nucleotide sequence ID" value="XM_447673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ21"/>
    <dbReference type="SMR" id="Q6FQ21"/>
    <dbReference type="FunCoup" id="Q6FQ21">
        <property type="interactions" value="1783"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ21"/>
    <dbReference type="EnsemblFungi" id="CAGL0I09790g-T">
        <property type="protein sequence ID" value="CAGL0I09790g-T-p1"/>
        <property type="gene ID" value="CAGL0I09790g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888946"/>
    <dbReference type="KEGG" id="cgr:2888946"/>
    <dbReference type="CGD" id="CAL0132264">
        <property type="gene designation" value="CAGL0I09790g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09790g"/>
    <dbReference type="eggNOG" id="KOG2572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015495_5_2_1"/>
    <dbReference type="InParanoid" id="Q6FQ21"/>
    <dbReference type="OMA" id="MGMRSNW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000350980" description="Nucleolar protein 58">
        <location>
            <begin position="1"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Nop" evidence="2">
        <location>
            <begin position="283"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="424"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="513" mass="57139" checksum="FB717700C5992DBC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ43</accession>
    <name>Q6FQ43_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GTP-binding protein YPT10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I09306g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ43"/>
    <dbReference type="FunCoup" id="Q6FQ43">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ43"/>
    <dbReference type="KEGG" id="cgr:2889125"/>
    <dbReference type="CGD" id="CAL0132480">
        <property type="gene designation" value="CAGL0I09306g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09306g"/>
    <dbReference type="eggNOG" id="KOG0092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="Q6FQ43"/>
    <dbReference type="OMA" id="HMEIWDT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23224" checksum="328B55F1488A594E" modified="2004-07-19" version="1">MSETLVYQKSLKVVLLGESAVGKSAIVTRFSTGKYLRNNATIGAAYVTKDLEYIRDGDVYQVRLEIWDTAGQERYRSLTPMYYRNTDVAIVVFDVSNLRSLSMAHKWIDELNTYVENKGRERINIVLVGNKMDLCSDEERSTLPQRVEEQFQAVSAKSGEGIEELFDHIVKGIPSDQFTLKSAAVEQPDNVVNLNNKSVLQSTCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQR5</accession>
    <name>Q6FQR5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Maintenance of telomere capping protein 3, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAGL0I04136g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQR5"/>
    <dbReference type="KEGG" id="cgr:2889101"/>
    <dbReference type="eggNOG" id="KOG4075">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="YLDWKME"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:respiratory chain complex IV"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
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        <location>
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            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="134" mass="16020" checksum="BE783E4F3DA67EAB" modified="2004-07-19" version="1">MPSTSARLGINYRLNSTLSWADEDEVYEPPNREIMQVPQKWSTYDYDLKEEIVEYLEWKQEDRWHEMSIPERRAAYYISFGEWGPRYTGQTKYDTSYVMLRGLFNLILFSSAGMAFYNLKKDKEMKKKIADLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
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    <name>Q6FQV6_CANGA</name>
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        <recommendedName>
            <fullName evidence="4">Cleavage/polyadenylation specificity factor A subunit N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1 2" type="ordered locus">CAGL0I03212g</name>
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    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
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            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
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                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
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                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
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            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_447388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQV6"/>
    <dbReference type="KEGG" id="cgr:2889169"/>
    <dbReference type="CGD" id="CAL0132416">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03212g"/>
    <dbReference type="HOGENOM" id="CLU_307175_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQV6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="963" mass="110871" checksum="91290DA1C06DA797" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR60</accession>
    <name>Q6FR60_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribophorin II C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0I00704g</name>
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    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
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            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR60"/>
    <dbReference type="KEGG" id="cgr:2889329"/>
    <dbReference type="CGD" id="CAL0130424">
        <property type="gene designation" value="CAGL0I00704g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00704g"/>
    <dbReference type="eggNOG" id="KOG2447">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079423_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR60"/>
    <dbReference type="OMA" id="SIVTHYV"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044244372" description="Ribophorin II C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="9">
        <location>
            <begin position="175"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0130424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="276" mass="31083" checksum="19FADF67E6AC913E" modified="2004-07-19" version="1">MRWSQLALFSIFSYITLALRLTDVNVINYTDDEKKLLTFKEVSADIVTDQQLKVIEVTIPDAIYLVTFKSETPLDQANVYLGHPDKSLEVVYPIKERAGDIYLFEINMDKLDKNLLAVQKELGNKPLAVTVVAASKDDSEGVLKTLFYMQLQESMLTEELPQRELAIKKELAHTFNKPPTHAPKLFAQLFALIILATFAALVITWFAAGAVNFGNMPKGNFIYFIGFVVTIVGFEYIFTQYQLGTGIFETINRAICLGVPGIWISAKFLRSVEKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR96</accession>
    <name>Q6FR96_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H10362g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR96"/>
    <dbReference type="FunCoup" id="Q6FR96">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR96"/>
    <dbReference type="KEGG" id="cgr:2888613"/>
    <dbReference type="CGD" id="CAL0131752">
        <property type="gene designation" value="CAGL0H10362g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10362g"/>
    <dbReference type="eggNOG" id="ENOG502S4G9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141797_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR96"/>
    <dbReference type="OMA" id="NAPNSVY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0131752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="16916" checksum="415F43A389A36112" modified="2004-07-19" version="1">MTSASGMKRPVDVANFKIAIRDMGDDELGRVKQEVENSIRHLTRSNERLHRYIKKLQGHAVELEDGEEMDENLGSDDIELFQESIRENELVLDNSRERLEALHDELAYRKAQHPDGKSNPEGSLAERKLSAIDMDNTNVDVAAPNSIYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRH1</accession>
    <name>NDOR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="1">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TAH18</name>
        <name type="ordered locus">CAGL0H08580g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:67717"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="1">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447173.1">
        <property type="nucleotide sequence ID" value="XM_447173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRH1"/>
    <dbReference type="SMR" id="Q6FRH1"/>
    <dbReference type="FunCoup" id="Q6FRH1">
        <property type="interactions" value="790"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRH1"/>
    <dbReference type="EnsemblFungi" id="CAGL0H08580g-T">
        <property type="protein sequence ID" value="CAGL0H08580g-T-p1"/>
        <property type="gene ID" value="CAGL0H08580g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888507"/>
    <dbReference type="KEGG" id="cgr:2888507"/>
    <dbReference type="CGD" id="CAL0131952">
        <property type="gene designation" value="CAGL0H08580g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08580g"/>
    <dbReference type="eggNOG" id="KOG1159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001570_17_6_1"/>
    <dbReference type="InParanoid" id="Q6FRH1"/>
    <dbReference type="OMA" id="DIMSIPR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045429">
        <property type="term" value="P:positive regulation of nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000008">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000056">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000167615" description="NADPH-dependent diflavin oxidoreductase 1">
        <location>
            <begin position="1"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="224"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="411"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="443"/>
            <end position="446"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="536"/>
            <end position="537"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="545"/>
            <end position="549"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="621"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <sequence length="621" mass="72063" checksum="F86500B647149345" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-02-28" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRT5</accession>
    <name>FLR2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multidrug transporter FLR2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Drug:H(+) antiporter FLR2</fullName>
            <shortName evidence="5">DHA FLR2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Flucytosine exporter FLR2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FLR2</name>
        <name type="ordered locus">CAGL0H06039g</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="2045" last="2045">
            <title>Membrane Proteomics analysis of the Candida glabrata response to 5-flucytosine: unveiling the role and regulation of the drug efflux transporters CgFlr1 and CgFlr2.</title>
            <authorList>
                <person name="Pais P."/>
                <person name="Pires C."/>
                <person name="Costa C."/>
                <person name="Okamoto M."/>
                <person name="Chibana H."/>
                <person name="Teixeira M.C."/>
            </authorList>
            <dbReference type="PubMed" id="28066366"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.02045"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Multidrug transporter that confers resistance to 5-flucytosine (5-FC) and clotrimazole (PubMed:28066366). Further confers azole drug resistance (PubMed:28066366). Plays direct roles in extrusion of 5-flucytosine and clotrimazole (PubMed:28066366).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is regulated by the transcription factors AP1 and PDR1 (PubMed:28066366).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Increases the intracellular accumulation of 5-flucytosine and clotrimazole (PubMed:28066366).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447059.1">
        <property type="nucleotide sequence ID" value="XM_447059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRT5"/>
    <dbReference type="FunCoup" id="Q6FRT5">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRT5"/>
    <dbReference type="GlyCosmos" id="Q6FRT5">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0H06039g-T">
        <property type="protein sequence ID" value="CAGL0H06039g-T-p1"/>
        <property type="gene ID" value="CAGL0H06039g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888685"/>
    <dbReference type="KEGG" id="cgr:2888685"/>
    <dbReference type="CGD" id="CAL0130474">
        <property type="gene designation" value="FLR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06039g"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_1_1"/>
    <dbReference type="InParanoid" id="Q6FRT5"/>
    <dbReference type="OMA" id="CYQAHAY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00880">
        <property type="entry name" value="2_A_01_02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000443412" description="Multidrug transporter FLR2">
        <location>
            <begin position="1"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="28066366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="28066366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="589" mass="65989" checksum="4CBCC6ED9F5618B3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRV8</accession>
    <name>Q6FRV8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Modifier of transcription 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0H05533g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FRV8">
        <property type="interactions" value="1557"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRV8"/>
    <dbReference type="KEGG" id="cgr:2888821"/>
    <dbReference type="CGD" id="CAL0129490">
        <property type="gene designation" value="CAGL0H05533g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05533g"/>
    <dbReference type="eggNOG" id="KOG0392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FRV8"/>
    <dbReference type="OMA" id="WYSDIAC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045898">
        <property type="term" value="P:regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1325"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1678"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="203"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0129490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG59969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1904" mass="215175" checksum="81D4A964A1AD0411" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRZ5</accession>
    <name>SPT5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Transcription elongation factor SPT5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Chromatin elongation factor SPT5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SPT5</name>
        <name type="ordered locus">CAGL0H04697g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPT5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446999.1">
        <property type="nucleotide sequence ID" value="XM_446999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRZ5"/>
    <dbReference type="SMR" id="Q6FRZ5"/>
    <dbReference type="FunCoup" id="Q6FRZ5">
        <property type="interactions" value="1508"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRZ5"/>
    <dbReference type="EnsemblFungi" id="CAGL0H04697g-T">
        <property type="protein sequence ID" value="CAGL0H04697g-T-p1"/>
        <property type="gene ID" value="CAGL0H04697g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888499"/>
    <dbReference type="KEGG" id="cgr:2888499"/>
    <dbReference type="CGD" id="CAL0131556">
        <property type="gene designation" value="CAGL0H04697g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04697g"/>
    <dbReference type="eggNOG" id="KOG1999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003537_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FRZ5"/>
    <dbReference type="OMA" id="YPVGYMN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140463">
        <property type="term" value="F:chromatin-protein adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
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    <sequence length="1010" mass="109825" checksum="57BC37D4F86367E7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS38</accession>
    <name>Q6FS38_CANGA</name>
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        <recommendedName>
            <fullName evidence="2">Target of rapamycin complex subunit LST8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0H03729g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat LST8 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG59889.1"/>
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        <property type="term" value="C:endosome membrane"/>
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    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
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        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
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        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
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        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
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        <property type="term" value="P:regulation of cell growth"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000339">
        <property type="entry name" value="WD-repeat protein pop3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037588">
        <property type="entry name" value="MLST8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842">
        <property type="entry name" value="G BETA-LIKE PROTEIN GBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19842:SF0">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX SUBUNIT LST8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="71"/>
            <end position="112"/>
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    <feature type="repeat" description="WD" evidence="5">
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            <begin position="112"/>
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    <feature type="repeat" description="WD" evidence="5">
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            <begin position="203"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0130494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="303" mass="33897" checksum="84CD89C653C786CA" modified="2004-07-19" version="1">MSVLLVSAGYDHTIRFWEALTGVCLRTIQHPDSQVNRLEITNDKKLLAAAGHQNIRLYDIKTSNSNPVASFEGHRGNVTSVSFQQDNKWMVTSSEDGTIKVWDIRSPSVPRNYKHNAPVNEVVIHPNQGELISCDRDGNIRIWDLGENQCTHQLTPEDDVPLQSLSVASDGSMLVAANNKGNCYVWEMPNHTDASNLKPATKFKAHPSYITRVLLSSDVKHMATCSADHTARIWSVEDNFNLESTLDGHQRWVWDCAFSADSAYLVTASSDHYVRLWDLSTRDIIRQYGGHHKGAVCVALNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS77</accession>
    <name>Q6FS77_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0H02827g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FS77">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS77"/>
    <dbReference type="KEGG" id="cgr:2888491"/>
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        <property type="gene designation" value="CAGL0H02827g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02827g"/>
    <dbReference type="eggNOG" id="KOG0715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030116_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS77"/>
    <dbReference type="OMA" id="DMDYKPC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051727">
        <property type="entry name" value="DnaJ_C3_Co-chaperones"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44140:SF2">
        <property type="entry name" value="LD25575P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273528" description="J domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="541"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="612"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0131748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="656" mass="76179" checksum="B3C274C0344BC2C3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSS5</accession>
    <name>Q6FSS5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G08195g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446719.1">
        <property type="nucleotide sequence ID" value="XM_446719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSS5"/>
    <dbReference type="FunCoup" id="Q6FSS5">
        <property type="interactions" value="1066"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSS5"/>
    <dbReference type="KEGG" id="cgr:2888208"/>
    <dbReference type="CGD" id="CAL0129981">
        <property type="gene designation" value="CAGL0G08195g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08195g"/>
    <dbReference type="eggNOG" id="KOG3336">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067902_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FSS5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="224" mass="25823" checksum="838BC779BE74E91F" modified="2004-07-19" version="1">MRLFQNTCEFAYPWDQVTAANWNKYPNEVSTHVVAVDVLRRELSASGRQLVTERLITVKQSVPRWVLLVVGASKQSYVREVSTVDLDTRTLTMRSCNLTFWNIMKVYETVKYMPDAVNPDKTVFKQEAQISVCGTLGRFCNKVEEWSVQRFGENAKKGKMGFDLVLKVFNEHWNQINSDIENVFNETVEDVRSTAGNLIKETERTYSNILGTNQEIFSEAFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FST9</accession>
    <name>Q6FST9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit S1/VOA1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0G07887g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FST9"/>
    <dbReference type="FunCoup" id="Q6FST9">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FST9"/>
    <dbReference type="KEGG" id="cgr:2888382"/>
    <dbReference type="CGD" id="CAL0137691">
        <property type="gene designation" value="CAGL0G07887g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07887g"/>
    <dbReference type="eggNOG" id="ENOG502S5C0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1147051_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FST9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046756">
        <property type="entry name" value="VAS1/VOA1_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20520">
        <property type="entry name" value="Ac45-VOA1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274847" description="V-type proton ATPase subunit S1/VOA1 transmembrane domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="V-type proton ATPase subunit S1/VOA1 transmembrane" evidence="7">
        <location>
            <begin position="195"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="242" mass="27823" checksum="3D0AC17F70E0B6FA" modified="2004-07-19" version="1">MMIKQLFVSLFLLFSYAVASNKFFLTFSDSELNTDSLSVAASESNTPLLIIKVLNIDVLRNLFTSLKNEEVGKYTFWRLIEEDIGQVDSYVIDSNYDQVKSEANKYTLEFQENLDNYEKVSEIIQQNILNLETKSQTLPLLALELTSDNKKVRRDRIIDEIEEILEEYDILDFFDDNESDDKNNEGKTPSEESRIWTEGLLMCLIVSGILLIILIISLSWLSDLSISYGALERPNNMAKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT79</accession>
    <name>Q6FT79_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0G04719g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="4"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446565.1">
        <property type="nucleotide sequence ID" value="XM_446565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT79"/>
    <dbReference type="STRING" id="284593.Q6FT79"/>
    <dbReference type="KEGG" id="cgr:2888163"/>
    <dbReference type="CGD" id="CAL0130843">
        <property type="gene designation" value="CAGL0G04719g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04719g"/>
    <dbReference type="eggNOG" id="KOG0566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FT79"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000029">
        <property type="entry name" value="Inositol polyphosphate 5-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF257">
        <property type="entry name" value="PHOSPHOINOSITIDE 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAC" evidence="11">
        <location>
            <begin position="142"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="896"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="896"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="931"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0130843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="959" mass="109513" checksum="36985BDF0C982619" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT81</accession>
    <name>Q6FT81_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">37S ribosomal protein RSM28, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G04675g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT81"/>
    <dbReference type="FunCoup" id="Q6FT81">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT81"/>
    <dbReference type="KEGG" id="cgr:2887994"/>
    <dbReference type="CGD" id="CAL0130791">
        <property type="gene designation" value="CAGL0G04675g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04675g"/>
    <dbReference type="eggNOG" id="ENOG502S2AE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071897_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT81"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35710" checksum="61AD49AA84F64F44" modified="2004-07-19" version="1">MWGLKSISTVGVRTYSSQVTHDFLNSILARAQEATAKNKEVVQANHARAPLRNRTRQQDGGQQRPANKIRQRNGKVQAKFQVRDENSNRAIPDLKTKQPQFKRAQRNNRDGQADVLDVMDAGTGKTNRASMSAKRSNKFTKRGKGSHVIEAVSLSKKPTSAREIALKKSVDSVSYEPVEPTPLSLLAYSTPIFNTHKSNILQISMQTIKNAASPKNTPSGFDAIHSGIMNKERLLNSSQLDVDVDRLKQIARGQYFSLPVLQNKAFDSLTKSEDKKKQLVENSNVVRRSLDSLDIEPEKKEILYAVCSGTQPVSEVSQLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTB6</accession>
    <name>Q6FTB6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Pore membrane protein of 33 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0G03773g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTB6"/>
    <dbReference type="FunCoup" id="Q6FTB6">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTB6"/>
    <dbReference type="KEGG" id="cgr:2888374"/>
    <dbReference type="CGD" id="CAL0130729">
        <property type="gene designation" value="CAGL0G03773g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03773g"/>
    <dbReference type="eggNOG" id="KOG4002">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065417_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTB6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF6">
        <property type="entry name" value="PORE MEMBRANE PROTEIN OF 33 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="246"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0130729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="32070" checksum="C1BDBDEA8517C550" modified="2004-07-19" version="1">MPPKVPATTVKDRFLKVAKSLQFAWFAGHFLVVVSSLLYLFRFCETLYRCAYVGVLASFGIITYQQGLHQQLSLSLLTNENVLYFALALVWFFTPRFSLSLVPYFMFSVFHVLVYLKTTLLPQVFNQTVESKSKVVMFIDKFVLDYNERCMYWVSTTELLMLFLLFVRAVLFFSRSWIVLVVFTLFIKVKYETSKYMQAAFAQWRVRMDGVISHPSVPPQIKSLYNQLKFQLVQLSKVTITRAAPGTHGSTSASTGSTGTSTSTSTSTSGASASATATHSAKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTB8</accession>
    <name>Q6FTB8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear division defective protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G03729g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTB8"/>
    <dbReference type="FunCoup" id="Q6FTB8">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTB8"/>
    <dbReference type="KEGG" id="cgr:2888372"/>
    <dbReference type="CGD" id="CAL0130245">
        <property type="gene designation" value="CAGL0G03729g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03729g"/>
    <dbReference type="eggNOG" id="ENOG502RUKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023935_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTB8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="64892" checksum="224F63B1F4269854" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTF1</accession>
    <name>Q6FTF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0G03003g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTF1"/>
    <dbReference type="FunCoup" id="Q6FTF1">
        <property type="interactions" value="1145"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTF1"/>
    <dbReference type="KEGG" id="cgr:2888356"/>
    <dbReference type="CGD" id="CAL0130805">
        <property type="gene designation" value="CAGL0G03003g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03003g"/>
    <dbReference type="eggNOG" id="KOG2054">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003502_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTF1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3030:FF:000002">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="168"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="323"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="485"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="670"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="863"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="1047"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0130805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1191" mass="135791" checksum="84D29F0D3A7B9769" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTI2</accession>
    <name>Q6FTI2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0G02299g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTI2"/>
    <dbReference type="FunCoup" id="Q6FTI2">
        <property type="interactions" value="893"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTI2"/>
    <dbReference type="KEGG" id="cgr:2888361"/>
    <dbReference type="CGD" id="CAL0137549">
        <property type="gene designation" value="CAGL0G02299g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02299g"/>
    <dbReference type="eggNOG" id="KOG0924">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_6_3_1"/>
    <dbReference type="InParanoid" id="Q6FTI2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000378">
        <property type="term" value="P:RNA exon ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040031">
        <property type="term" value="P:snRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="351"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="529"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="273"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0137549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG59389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1057" mass="119057" checksum="277D477C7D205E38" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTK8</accession>
    <name>Q6FTK8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sphingolipid long chain base-responsive protein PIL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G01738g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446436.1">
        <property type="nucleotide sequence ID" value="XM_446436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTK8"/>
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    <dbReference type="KEGG" id="cgr:2888013"/>
    <dbReference type="CGD" id="CAL0137535">
        <property type="gene designation" value="CAGL0G01738g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01738g"/>
    <dbReference type="eggNOG" id="ENOG502QQ1T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046464_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTK8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036286">
        <property type="term" value="C:eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31962:SF1">
        <property type="entry name" value="SPHINGOLIPID LONG CHAIN BASE-RESPONSIVE PROTEIN PIL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="35056" checksum="60C3F1D63D9E80EF" modified="2004-07-19" version="1">MHKTYSLRESRKPTAQEIQSPPPPAASTKSKFFGKGGLAYSLRKTTAGNVGPELSRKLSKLVKIEKNVMRSMEVASVEKKDAAKTLSLWGLENDDDVSDITDKLGVIIFEMAELDDQFVDRYDQYRLTMKSIRDIEGSVQPVRDRKDKITDKIAYMKYKDPHSQKIEILEQELVRCEAETLVAEAQLSNITRSKMKAAFNYQFDAMIEHSEKIALLAGYGKALLELLDDGPVTPGETRPTYDGYEASKQIIVDAEGALNEWTLDNAQVRPSLSFKEQEYTVEEVEDEEDEYENEPLNETVINPEDMTPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTK9</accession>
    <name>Q6FTK9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G01716g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTK9"/>
    <dbReference type="FunCoup" id="Q6FTK9">
        <property type="interactions" value="299"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888375"/>
    <dbReference type="CGD" id="CAL0129387">
        <property type="gene designation" value="CAGL0G01716g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01716g"/>
    <dbReference type="eggNOG" id="ENOG502RW7G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050275_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTK9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106279">
        <property type="term" value="P:negative regulation of UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF68">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATG1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="380" mass="43373" checksum="E7D1B2713ECD0A67" modified="2004-07-19" version="1">MDTPPTSPAFTTSRYMPLSPELEEGKCSQSSLDLLQSDLELCSKNGNKVMDVMALYHGTLASVACQVYGDRNVDLYLNPSLKIGKVRDRGSVSFIFDLEDRYVIKCPMSRRKYDIILREALILRLLQAPDNNIVPLIGVTYLGKSHFRHLRANELVPALVLQKFELNLHTYINLHRGDIQPDKGVWHSLLRDILCALKFMKSKNIVHRDIKTSNILLNLPRHDTDTTRFYLADFTSADIEGPEEFNTTHDHVDTTLEYCAPELISFFSDMPMSNHSSHIVGTPSMHTDLYAAGLCLLSFITGYEPYDQLFNSSSTNETRSRSASPVQKSQWLINAISKMDPISLNIQDQRIYDIWREELQILNAILVERKPLEEIMQLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTS7</accession>
    <name>Q6FTS7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="5">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0F09185g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = (6R)-5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTS7"/>
    <dbReference type="FunCoup" id="Q6FTS7">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTS7"/>
    <dbReference type="KEGG" id="cgr:2887631"/>
    <dbReference type="CGD" id="CAL0131278">
        <property type="gene designation" value="CAGL0F09185g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F09185g"/>
    <dbReference type="eggNOG" id="KOG3093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FTS7"/>
    <dbReference type="OMA" id="DKWGIPT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407">
        <property type="entry name" value="ATPASE INHIBITOR/5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="8"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="162"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0131278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="229" mass="25854" checksum="24B0C537E83706D6" modified="2004-07-19" version="1">MNEMLAVKQQLRKHMGQTLGKISREEIISQSECIRDNLMPILEGKQNVACYMSMDTGELDTGNIIESLFEAGKKVYLPRCTHTKLTGHVQLRNDSKNPGNMKDHPHLTFHEMDSHDHVLSLSPKGKYNLKEPDIEDEKLSPLPPMLDAILVPGVAFTSGCSRLGHGAGYYDDFFSRYKLQHSNQLPLLIGIALKQQIVEDIPMDAHDYFLDCILVGDGSIHWRNKPITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU49</accession>
    <name>Q6FU49_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0F06391g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BUB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU49"/>
    <dbReference type="FunCoup" id="Q6FU49">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU49"/>
    <dbReference type="KEGG" id="cgr:2887860"/>
    <dbReference type="CGD" id="CAL0129341">
        <property type="gene designation" value="CAGL0F06391g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06391g"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029367_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FU49"/>
    <dbReference type="OMA" id="CHKSEPQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902543">
        <property type="term" value="P:negative regulation of protein localization to mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031030">
        <property type="term" value="P:negative regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000035">
        <property type="entry name" value="Cell cycle arrest protein BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000026">
        <property type="entry name" value="Mitotic check point protein (Bub2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF263">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="7">
        <location>
            <begin position="63"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="334" mass="37532" checksum="84820E589C3F5F25" modified="2004-07-19" version="1">MEKFISHPPLLVHTSLSQLRYLILSEGIPVAGNDKRKRSKRGNLSGGDEVDSGGSEADTHSQQSIKRLRCYVWSILSRTSMERCSQKYLALLQLGPPETHILQKIKNDTSRTLQTDPKFRAQVSEDALLRCLSCFAWEIERKKRQAGEGDTVDVSAYVQGMNVLLAPLLYSCPSEAMAYQLFSTMCKRIIPAYLTRSLAGAQNGARLLDACLRIVDPKLSKYLGDNLLPAEIYGMPSILTLSSCNKPLDQVCRLWDFMFAYGFHMNVLFVVAQLVSIRSKIFESESPMNMLRQLPEFDADEIIRLGVGFVAKIPPDLYDLLIRHLTDPDIVIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUB7</accession>
    <name>Q6FUB7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0F04741g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446177.1">
        <property type="nucleotide sequence ID" value="XM_446177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUB7"/>
    <dbReference type="FunCoup" id="Q6FUB7">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUB7"/>
    <dbReference type="KEGG" id="cgr:2887937"/>
    <dbReference type="CGD" id="CAL0129333">
        <property type="gene designation" value="CAGL0F04741g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04741g"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_0_1"/>
    <dbReference type="InParanoid" id="Q6FUB7"/>
    <dbReference type="OMA" id="HDWFESR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004683">
        <property type="term" value="F:calcium/calmodulin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000449">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000278">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="45"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0129333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG59101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="442" mass="49884" checksum="419B716B0A094C86" modified="2004-07-19" version="1">MVDNKDENKDKPAVRKPEQVEGHTVTKFFNKLNGQPESYVSKSNYVFGKTLGAGTFGVVRQARYSPTNEDVAVKILLKKALKGNDVQLQMLYDELSILQMLKHPNIVEFKDWFESKDKFYIVTQLAVGGELFDRILAKGKFTERDAVSITMQILSAVDYMHSKNVVHRDLKPENVLYIDKSDDSQLVIADFGIAKQLQDNDDLIFKAAGSLGYVAPEVLTNNGHGKPCDIWSIGVIVYTLLCGYSAFVAETVDGFLEECTQNKYPVTFHKPYWDNISDEAKNFILRALTLDPAERPTAAELMKDPWITNTRPETANIYPEIRKGFDLRKKLRDAIEIVKLNNRIKKLRSLYMVETDTDIEENVASVAFNTLASSLNDLRLHSQKRVGQLTAEQRRLKSALTQDTFAQIVRAATKNKERIWGEKTASPTPSQSSTSSTSTNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUL4</accession>
    <name>Q6FUL4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0F02541g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUL4"/>
    <dbReference type="FunCoup" id="Q6FUL4">
        <property type="interactions" value="862"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUL4"/>
    <dbReference type="KEGG" id="cgr:2887685"/>
    <dbReference type="CGD" id="CAL0129392">
        <property type="gene designation" value="CAGL0F02541g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02541g"/>
    <dbReference type="eggNOG" id="KOG4547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023936_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUL4"/>
    <dbReference type="OMA" id="WVKWCLI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="445"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="556"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0129392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="630" mass="70780" checksum="D68DE3D2DE9529D5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUM1</accession>
    <name>Q6FUM1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Factor arrest protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0F02365g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUM1"/>
    <dbReference type="FunCoup" id="Q6FUM1">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUM1"/>
    <dbReference type="KEGG" id="cgr:2887633"/>
    <dbReference type="CGD" id="CAL0129641">
        <property type="gene designation" value="CAGL0F02365g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02365g"/>
    <dbReference type="eggNOG" id="ENOG502S5IA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103442_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUM1"/>
    <dbReference type="OMA" id="HMYLLVN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000321">
        <property type="term" value="P:re-entry into mitotic cell cycle after pheromone arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0129641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="27137" checksum="D13C99569898C097" modified="2004-07-19" version="1">MYLLNDFTLLYKLSEKRSNRIKPQIIKDIMEGNVPPQAPQQLYMTPQSENLTHLYKLLEQLIQQLATNNEKKENILVAVDTLSNRVNSSETSVNDHYSSSARLIQQFLDRIDPVPDSQSSKDKNRVEETLRQQNKQLKEILLNSQSITRESYDILKYHEECLHEVIGHLRADILKDQRKVVNEIRTRFNKDVKALEDIEFQSYIDNVNEIQKLMDISYVYRTLLRLVTQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUP8</accession>
    <name>Q6FUP8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FRS1</name>
        <name evidence="18 19" type="ordered locus">CAGL0F01705g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446046.1">
        <property type="nucleotide sequence ID" value="XM_446046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUP8"/>
    <dbReference type="FunCoup" id="Q6FUP8">
        <property type="interactions" value="1175"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUP8"/>
    <dbReference type="GeneID" id="2887944"/>
    <dbReference type="KEGG" id="cgr:2887944"/>
    <dbReference type="CGD" id="CAL0129751">
        <property type="gene designation" value="FRS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01705g"/>
    <dbReference type="eggNOG" id="KOG2472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020279_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FUP8"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="292"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0129751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG58970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="595" mass="67338" checksum="6EC66F032FE533FF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUR6</accession>
    <name>Q6FUR6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0F01243g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUR6"/>
    <dbReference type="FunCoup" id="Q6FUR6">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUR6"/>
    <dbReference type="KEGG" id="cgr:2887959"/>
    <dbReference type="CGD" id="CAL0131118">
        <property type="gene designation" value="CAGL0F01243g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01243g"/>
    <dbReference type="eggNOG" id="KOG1043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008958_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FUR6"/>
    <dbReference type="OMA" id="MAGYELS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="152"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="442"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0131118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="543" mass="61948" checksum="FAA06E2D47DE5216" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUU1</accession>
    <name>Q6FUU1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Myosin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0F00671g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FUU1">
        <property type="interactions" value="712"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUU1"/>
    <dbReference type="KEGG" id="cgr:2887842"/>
    <dbReference type="CGD" id="CAL0131116">
        <property type="gene designation" value="CAGL0F00671g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00671g"/>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FUU1"/>
    <dbReference type="OMA" id="EIMFDDR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031941">
        <property type="term" value="C:filamentous actin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071563">
        <property type="term" value="C:Myo2p-Vac17p-Vac8p transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048313">
        <property type="term" value="P:Golgi inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007107">
        <property type="term" value="P:membrane addition at site of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030050">
        <property type="term" value="P:vesicle transport along actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000023">
        <property type="entry name" value="Class V myosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000002">
        <property type="entry name" value="Class V myosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="4"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="70"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="1220"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="915"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="164"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0131116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1566" mass="178940" checksum="6137FBCCB36FC66A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUU8</accession>
    <name>Q6FUU8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-related protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0F00517g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUU8"/>
    <dbReference type="FunCoup" id="Q6FUU8">
        <property type="interactions" value="766"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUU8"/>
    <dbReference type="KEGG" id="cgr:2887664"/>
    <dbReference type="CGD" id="CAL0130966">
        <property type="gene designation" value="CAGL0F00517g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00517g"/>
    <dbReference type="eggNOG" id="KOG0678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FUU8"/>
    <dbReference type="OMA" id="GIHYPIR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0130966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="454" mass="50188" checksum="A3A8B3A0A8239B7C" modified="2004-07-19" version="1">MSYLNNPAVVMDNGTGLTKLGFAGNDSPSWVFPTAIATAQASNTKKSTVVNKSSAGGADSSGSGYFGNSTSATSFNSGDMSSLLLSNNLAGKRGTEDLDFYIGNEALAAAQGQSYSLSYPIRHGQVENWDHMERFWENSIFKYLRTEPEDHFFLLTEPPLNPPENREQVAEIFFESFNCAGLYIAVQAVLALAASWTSPKVTDRSLTGTVIDSGDGVTHVIPVAEGYVIGSAIKNIPIAGRDITLFIQQLLRERGEQDTSLKTAERIKQEYCYVCPDIVKEFNKFDRDASKFAQFVVESQEKTRKKIVDVGYERFLAPEIFFNPEIASSDFLTPLPTVVDETIQACPIDVRKGLYNNIVLSGGSTMFKDFGRRLQRDMKSIVNNRIAQSEALSGTKSTGVDVQVISHRKQRNAVWFGGSLLAQTAEFKSYCHTKKDYDEYGPEIVRNFSLFNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUU9</accession>
    <name>Q6FUU9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="15">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">CAGL0F00495g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Vacuole membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="15"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FUU9">
        <property type="interactions" value="1311"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUU9"/>
    <dbReference type="KEGG" id="cgr:2887695"/>
    <dbReference type="eggNOG" id="KOG0891">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_7_1_1"/>
    <dbReference type="InParanoid" id="Q6FUU9"/>
    <dbReference type="OMA" id="MRQHSAK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031137">
        <property type="term" value="P:regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FAT" evidence="17">
        <location>
            <begin position="1323"/>
            <end position="1905"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="16">
        <location>
            <begin position="2079"/>
            <end position="2394"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="18">
        <location>
            <begin position="2424"/>
            <end position="2456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG58919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="2456" mass="280013" checksum="4A96B02B1935D8D8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUY8</accession>
    <name>Q6FUY8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="18">2.3.1.86</ecNumber>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="18">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
                <ecNumber evidence="18">1.1.1.100</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="18">3-oxoacyl-[acyl-carrier-protein] synthase</fullName>
                <ecNumber evidence="18">2.3.1.41</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="26 27" type="ordered locus">CAGL0E06138g</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 18">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.86" evidence="18"/>
    <dbReference type="EC" id="1.1.1.100" evidence="18"/>
    <dbReference type="EC" id="2.3.1.41" evidence="18"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FUY8">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUY8"/>
    <dbReference type="KEGG" id="cgr:2887355"/>
    <dbReference type="CGD" id="CAL0129056">
        <property type="gene designation" value="CAGL0E06138g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06138g"/>
    <dbReference type="eggNOG" id="ENOG502QQJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000114_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUY8"/>
    <dbReference type="OMA" id="FPTLPDW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101026">
        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900535">
        <property type="term" value="P:palmitic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 21" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 18 22" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="24">
        <location>
            <begin position="145"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="25">
        <location>
            <begin position="1122"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="19">
        <location>
            <position position="1304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="1769"/>
            <end position="1771"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1769"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1770"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1771"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1795"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1805"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="1814"/>
            <end position="1830"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="1838"/>
            <end position="1841"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="1868"/>
            <end position="1870"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1869"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1870"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="22">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="CGD" id="CAL0129056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CAG58875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1883" mass="207651" checksum="499884B33695BE80" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV25</accession>
    <name>Q6FV25_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SCD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0E05302g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV25"/>
    <dbReference type="FunCoup" id="Q6FV25">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV25"/>
    <dbReference type="KEGG" id="cgr:2887283"/>
    <dbReference type="CGD" id="CAL0128692">
        <property type="gene designation" value="CAGL0E05302g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05302g"/>
    <dbReference type="eggNOG" id="ENOG502QQ7A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016142_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FV25"/>
    <dbReference type="OMA" id="YICLRTH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="312"/>
            <end position="340"/>
        </location>
    </feature>
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        <location>
            <begin position="509"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="756"/>
        </location>
    </feature>
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            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
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        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="698"/>
        </location>
    </feature>
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        <location>
            <begin position="699"/>
            <end position="716"/>
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    </feature>
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        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="829" mass="92381" checksum="0A0C99BBAF89369A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV55</accession>
    <name>Q6FV55_CANGA</name>
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        <recommendedName>
            <fullName evidence="16">Cell wall protein ECM33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PST1</name>
        <name evidence="13 14" type="ordered locus">CAGL0E04620g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPS2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG58808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV55"/>
    <dbReference type="GeneID" id="2887462"/>
    <dbReference type="KEGG" id="cgr:2887462"/>
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    <dbReference type="InParanoid" id="Q6FV55"/>
    <dbReference type="OMA" id="WANNITF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273605" description="Cell wall protein ECM33" evidence="12">
        <location>
            <begin position="18"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="359"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="359"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005798"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0128816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG58808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="44050" checksum="C94EDD2D32003C2D" modified="2004-07-19" version="1">MQLNHLLLSALISVASAANTTVPDVPSSCSFTTTTATAQSDLDKLAGCENIVGDVVISGSLGNAALANVKAIYGSFKVNNATSLNNLAADSLQKVTGTLALQSLTILTSASFGSLEEVDTINLITLPAISTFSSNLKSANNILISDTSLESIDGFSDLEEVAVFNINNNRYLTSLKSSVKTVSDSLQFSFNGDQSSLTFDDLLWANNITLRDVDEVSFKKLESVNSSLGFINNSISSLSVDNLKSVGQSFSIVSNDDLTSVSFANLSTIGGALVVANNTNLKDLSTFKNVQTIGGALIVTGNFTTLDMSSLKSVRGGADIETKAGNFSCDPFKKLQSKGGIQGDNFVCKNGATSTSISLTSRSSSASQSSSSQRASATASGNSSNSASTAASTSSANKQKSKGAAAGLADSFQGSSLMGALAAVALALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVM5</accession>
    <name>Q6FVM5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">37S ribosomal protein S24, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0E00715g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVM5"/>
    <dbReference type="FunCoup" id="Q6FVM5">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVM5"/>
    <dbReference type="KEGG" id="cgr:2887459"/>
    <dbReference type="CGD" id="CAL0128964">
        <property type="gene designation" value="CAGL0E00715g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00715g"/>
    <dbReference type="eggNOG" id="KOG3933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943997_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVM5"/>
    <dbReference type="OMA" id="YRQEYKP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017081">
        <property type="entry name" value="Ribosomal_mS35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019349">
        <property type="entry name" value="Ribosomal_mS35_mit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039848">
        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10213">
        <property type="entry name" value="MRP-S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036995">
        <property type="entry name" value="RSM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS35 mitochondrial conserved" evidence="2">
        <location>
            <begin position="158"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR036995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="309" mass="34888" checksum="A8C784898DC98710" modified="2004-07-19" version="1">MLRIIRSIGTAAGAAGSGAAGAAGAVAGLYREPAKWKGLKPETVISLYWERVAKMGKEYKQSPEELEALLGTSEYTGVPEAHIRKLYKYGEKGAMEIGAGAGPGAGAKARDVVGGFSRFQFDELPSQALDLVDQHREQRFYNRLAAYELPLLAKYRQEYKPPSASDVVTYKYFTYVGEEHPNSRKVVLSLKTESLGLEPRALHKFRVLARTRYDHETDLFKMSSDKFPEAQQNAKYLGDILKRLLQEAKDLSKDDFSDIPLDTRHTIAKNLRKKHSRRLRTIEFPEEWKRPEDAPVKKVNITEELMKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVS2</accession>
    <name>Q6FVS2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0D06094g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVS2"/>
    <dbReference type="FunCoup" id="Q6FVS2">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVS2"/>
    <dbReference type="KEGG" id="cgr:2887137"/>
    <dbReference type="CGD" id="CAL0128045">
        <property type="gene designation" value="CAGL0D06094g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D06094g"/>
    <dbReference type="eggNOG" id="ENOG502S27I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1619339_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVS2"/>
    <dbReference type="OMA" id="QYNTVKF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040722">
        <property type="entry name" value="Hit1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18268">
        <property type="entry name" value="Hit1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="158" mass="18147" checksum="CFBF52C355FE27A0" modified="2004-07-19" version="1">MSSGKECQICKKDDFKYKCPKCGIKYCSLACYKNEELHIHKDAVTTELKTEQEDKTSAKDKTESSVIKFKTEKYQNIYDNSPEIRELLNYNTVKFHLAKVHKILTTTVADSNDSTTSMSSEAKKQLAIDYLNTLRYGGIHYNEALEEFCQLTVAKLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVU8</accession>
    <name>Q6FVU8_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0D05456g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445646.1">
        <property type="nucleotide sequence ID" value="XM_445646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVU8"/>
    <dbReference type="KEGG" id="cgr:2887102"/>
    <dbReference type="CGD" id="CAL0128499">
        <property type="gene designation" value="CAGL0D05456g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05456g"/>
    <dbReference type="HOGENOM" id="CLU_1320732_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVU8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="208" mass="24506" checksum="FB60603077B1B318" modified="2004-07-19" version="1">MEKELKNGTFEPSLKHSCAKKRASRIFFSVRENVFAAQYREKLEITDFTFQAETGSQDLCFEKPKKCPGDVTTASHRRHSDVYRHSDITVTSPGHFRHDPVSNKPVRAPIFPPYQLPGRKAERADGHFVFFSFLDPRWIRNSGHYSRTFFPNVLFVYFYFPHDYAFEPHTMDGVILPPPLPRRMREKERRETLQTITEQIPSIYQIFF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVY5</accession>
    <name>PSF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PSF1</name>
        <name type="ordered locus">CAGL0D04466g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445609.1">
        <property type="nucleotide sequence ID" value="XM_445609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVY5"/>
    <dbReference type="SMR" id="Q6FVY5"/>
    <dbReference type="FunCoup" id="Q6FVY5">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVY5"/>
    <dbReference type="EnsemblFungi" id="CAGL0D04466g-T">
        <property type="protein sequence ID" value="CAGL0D04466g-T-p1"/>
        <property type="gene ID" value="CAGL0D04466g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887234"/>
    <dbReference type="KEGG" id="cgr:2887234"/>
    <dbReference type="CGD" id="CAL0128289">
        <property type="gene designation" value="CAGL0D04466g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D04466g"/>
    <dbReference type="eggNOG" id="KOG3303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079191_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVY5"/>
    <dbReference type="OMA" id="EAHRSQQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000278396" description="DNA replication complex GINS protein PSF1">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="222" mass="25662" checksum="AD1ED923EC050873" modified="2004-07-19" version="1">MYGDLANKLILEAKRTQQLNQRRVNEDLQSGGGVNLLSRLPIYHDELVRNILNEVDQLRRNAEFLRNNGNAEEFAHLDEKIVKCQYFVTLLCMERNKRCLLAYQKLRTDILDNIAWCNNGTGIELYSGSNEDETNSLSHYEQEYLKEYGELITELKSESMADIDLSGSLEPPSDVFIDVRVLKDAGEIQTEYGVFNLIKDSQFFVRQSDVERLIQQGYLQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW16</accession>
    <name>Q6FW16_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0D03740g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW16"/>
    <dbReference type="FunCoup" id="Q6FW16">
        <property type="interactions" value="696"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW16"/>
    <dbReference type="KEGG" id="cgr:2887101"/>
    <dbReference type="CGD" id="CAL0128221">
        <property type="gene designation" value="CAGL0D03740g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03740g"/>
    <dbReference type="eggNOG" id="KOG2363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048451_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FW16"/>
    <dbReference type="OMA" id="CYGPGIT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000081">
        <property type="entry name" value="RNase MRP subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0128221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG58489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="294" mass="32228" checksum="F48899BF62CAD7D3" modified="2004-07-19" version="1">MLVDLNVCWPQKDFKTPISAQDEANVRATLMTLKTLGYTHVALNFTVSQTEKFPNDARELNPMDINVRFKKLMEATGLKIYSRITLVIDDPSKGQSLAKVSQAYDIVAALPISEKGLTLATTNLDIDLLTFEYSQRLPMMLKHKTICSCVNRGVKVEIAYGAALRESFVRKQFVSNARSVIRSSRGRGIIISSGAASPSECRNVLGASSIISFLGLKSDSCSRAMGEVPSLVLLNGRLRNKSYKQTVAVGTASNGSNVVESKLEDDSRNIKIVARDISATAEPDQGPERKKRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW22</accession>
    <name>Q6FW22_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0D03608g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445572.1">
        <property type="nucleotide sequence ID" value="XM_445572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW22"/>
    <dbReference type="KEGG" id="cgr:2887061"/>
    <dbReference type="CGD" id="CAL0128051">
        <property type="gene designation" value="CAGL0D03608g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03608g"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_621117_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW22"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF149">
        <property type="entry name" value="PROTEIN GAT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="6">
        <location>
            <begin position="379"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="321"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0128051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="441" mass="47773" checksum="E8931B01F7126371" modified="2004-07-19" version="1">MPLPPIYTNRFGYENSNISLPSFSELTSMLNLPRYTLPKPRIQICSHLRPRTQATTGGIDGTANNKPISAYIFMERQPQTTPKIPIVSGSSVSPGAATPYYGALPYDVSRRKLSIASLDNGIRPVNSLSPTISITPVSSYGSVPPKLASVALDNPGVPEPSFAPPSMPRINGVCSHRYKIKVTPERETSSMRARCNNSGADKLHSLSAVASALVEEECMVKTENSYPLSPDSINNSVLKSRNNSIDSLISGAIPKFDKEARNNCDGAAQELPAKASYIVSATDDVKEVPSVTLTSSATSNDVTVESQLITAERDAIILAGSQRRESQRSSGSSGSHGSALSQDSSEPKFNTIGSSIRRRKSKPGKVSKSGKNRNVFGYCLQCGKVDTPEWRNGPQGKATLCNACGLFYKKLKKYFADENMAIQFMQHRSIVDPEDRTMPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW40</accession>
    <name>Q6FW40_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 22" type="ordered locus">CAGL0D03168g</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FW40">
        <property type="interactions" value="583"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW40"/>
    <dbReference type="KEGG" id="cgr:2887067"/>
    <dbReference type="CGD" id="CAL0128339">
        <property type="gene designation" value="CAGL0D03168g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03168g"/>
    <dbReference type="eggNOG" id="KOG0618">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000430_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FW40"/>
    <dbReference type="OMA" id="PKRHYAI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01775">
        <property type="entry name" value="RA_PHLPP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000084">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013716">
        <property type="entry name" value="Adenylate_cyclase_G-a-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048580">
        <property type="entry name" value="CYAA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
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    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="9" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="732"/>
            <end position="811"/>
        </location>
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        <location>
            <begin position="1412"/>
            <end position="1679"/>
        </location>
    </feature>
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        <location>
            <begin position="1723"/>
            <end position="1860"/>
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            <begin position="1"/>
            <end position="92"/>
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            <begin position="149"/>
            <end position="226"/>
        </location>
    </feature>
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            <begin position="277"/>
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        </location>
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            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
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            <begin position="527"/>
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        </location>
    </feature>
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            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
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            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
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            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
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            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
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            <begin position="345"/>
            <end position="374"/>
        </location>
    </feature>
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        <location>
            <begin position="396"/>
            <end position="426"/>
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            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
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        <location>
            <begin position="639"/>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00003896"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50125"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="EMBL" id="CAG58465.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="2082" mass="235246" checksum="D857810BC1522E67" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW71</accession>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
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        <name evidence="8" type="ordered locus">CAGL0D02486g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
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            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="OAF3"/>
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        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR31069:SF29">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
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        <location>
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            <begin position="22"/>
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        <location>
            <begin position="42"/>
            <end position="51"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58434.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="878" mass="101451" checksum="285428B4F5AC3776" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWJ1</accession>
    <name>Q6FWJ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0C05269g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
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        <dbReference type="NCBI Taxonomy" id="284593"/>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWJ1"/>
    <dbReference type="FunCoup" id="Q6FWJ1">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWJ1"/>
    <dbReference type="KEGG" id="cgr:2886838"/>
    <dbReference type="CGD" id="CAL0127330">
        <property type="gene designation" value="CAGL0C05269g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05269g"/>
    <dbReference type="eggNOG" id="KOG0565">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025224_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FWJ1"/>
    <dbReference type="OMA" id="ITIWARC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="377" mass="43549" checksum="324BC07E732A8DCF" modified="2004-07-19" version="1">MSTTNSDSNGLWDVSVVTLNCARDFPFRDQQEKLAILKELITFNSNNAQDIYAFGFQELVRIWEGAGKIRMEAALIDILKDILDILDELFPQNNYKKLGYSYVGATAVLVVGKETIECHDSASTTSNCGKFGSTLKGGTAYSFRLKKNESTVLQTFTFISCHLNANEGEDNMTSRINDYDRIMTQCNRDFSDLEFRKGHIFVFGDLNFRVNDPNFKAHIASEWEPTLRKHEELNHLRAKHVIFRGFDEQPVTFPPTYKYKVGDMISYNNKRIPSWCDRILYKKYPSGLPMGKARYESLERVRHMQFTDHQAVGLAIQVPDLTKDNKHELELIRLLEPLNETLGYFADTLLAYEWLRRSTPVYILAALILFYFFYNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWV6</accession>
    <name>Q6FWV6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Antiviral helicase SKI2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0C02563g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FWV6">
        <property type="interactions" value="1008"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWV6"/>
    <dbReference type="KEGG" id="cgr:2886924"/>
    <dbReference type="CGD" id="CAL0127486">
        <property type="gene designation" value="CAGL0C02563g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02563g"/>
    <dbReference type="eggNOG" id="KOG0947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002902_1_4_1"/>
    <dbReference type="InParanoid" id="Q6FWV6"/>
    <dbReference type="OMA" id="DHVNIIM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048727">
        <property type="entry name" value="Ski2_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21409">
        <property type="entry name" value="Ski2_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="336"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="610"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="542"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0127486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1283" mass="146180" checksum="CF265BAFCE263D43" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWY5</accession>
    <name>DXO_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Decapping nuclease RAI1</fullName>
            <shortName evidence="7">CgRai1</shortName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD-capped RNA hydrolase RAI1</fullName>
            <shortName evidence="8">DeNADding enzyme RAI1</shortName>
            <ecNumber evidence="1">3.6.1.-</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RAI1</name>
        <name type="ordered locus">CAGL0C01925g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="Nucleic Acids Res." volume="43" first="6596" last="6606">
            <title>Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes.</title>
            <authorList>
                <person name="Wang V.Y."/>
                <person name="Jiao X."/>
                <person name="Kiledjian M."/>
                <person name="Tong L."/>
            </authorList>
            <dbReference type="PubMed" id="26101253"/>
            <dbReference type="DOI" id="10.1093/nar/gkv620"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 2 4 6">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs (PubMed:26101253). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (By similarity). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Divalent metal cation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with RAT1; the interaction is direct, stabilizes RAT1 protein structure and stimulates its exoribonuclease activity (By similarity). The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6 1"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445259.1">
        <property type="nucleotide sequence ID" value="XM_445259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWY5"/>
    <dbReference type="SMR" id="Q6FWY5"/>
    <dbReference type="FunCoup" id="Q6FWY5">
        <property type="interactions" value="678"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWY5"/>
    <dbReference type="EnsemblFungi" id="CAGL0C01925g-T">
        <property type="protein sequence ID" value="CAGL0C01925g-T-p1"/>
        <property type="gene ID" value="CAGL0C01925g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886817"/>
    <dbReference type="KEGG" id="cgr:2886817"/>
    <dbReference type="CGD" id="CAL0127586">
        <property type="gene designation" value="CAGL0C01925g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C01925g"/>
    <dbReference type="eggNOG" id="KOG1982">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024877_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FWY5"/>
    <dbReference type="OMA" id="VVTWRGH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110103">
        <property type="term" value="C:RNA polymerase II termination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990174">
        <property type="term" value="F:phosphodiesterase decapping endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110152">
        <property type="term" value="F:RNA NAD+-cap (NAD+-forming) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904595">
        <property type="term" value="P:positive regulation of termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030846">
        <property type="term" value="P:termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000249829" description="Decapping nuclease RAI1">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O13836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O70348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P53063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q06349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="5">
        <source>
            <dbReference type="UniProtKB" id="Q5AAT0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="26101253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="26101253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <sequence length="400" mass="46191" checksum="B68549B0504FFE58" modified="2007-01-23" version="3">MGISANLFVNQKGTTTALKQPKEIGYYSRNQTEEYLVSDDINLRYYYLPDQEIEHGIDLSAGASKFRDVAKDFKDRCSLKGLLDTLMEYEKKKNKKSNVDIITFRGIMSKLIRASMEPPNFNKVDLRIVSYDGQLFIKDVSDYNAATNESNSSGVNSRQQAGTSRQQIDTYTGYKFEGIATLDKPLPYVEREVIEKRPRKILNNGDEYITVVRTGVGECKVVLGAEIDCIFDFKEEGKDNLKHYTELKCSSQISTTNDVRRFEKKMFRAWLQCFLVGVPRVIYGFRDDQYMLKTVEEFSTEEIPVIIKANNPTLGQSCLDAIKWYGLFTDWLLKIIPREQSGNIRAYRLVYENNHLRLSEIEEQDGEYSRYVLEDGILTPEFKEWRESLRVPSEETPKAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX38</accession>
    <name>CCZ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Vacuolar fusion protein CCZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CCZ1</name>
        <name type="ordered locus">CAGL0C00561g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms a complex with MON1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
            <location evidence="1">Multivesicular body membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCZ1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445206.1">
        <property type="nucleotide sequence ID" value="XM_445206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX38"/>
    <dbReference type="FunCoup" id="Q6FX38">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX38"/>
    <dbReference type="EnsemblFungi" id="CAGL0C00561g-T">
        <property type="protein sequence ID" value="CAGL0C00561g-T-p1"/>
        <property type="gene ID" value="CAGL0C00561g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886768"/>
    <dbReference type="KEGG" id="cgr:2886768"/>
    <dbReference type="CGD" id="CAL0127504">
        <property type="gene designation" value="CAGL0C00561g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00561g"/>
    <dbReference type="eggNOG" id="ENOG502QSQV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_418686_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX38"/>
    <dbReference type="OMA" id="YNCLFWY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044395">
        <property type="term" value="P:protein targeting to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043987">
        <property type="entry name" value="CCZ1/INTU/HSP4_longin_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19031">
        <property type="entry name" value="Intu_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011668">
        <property type="entry name" value="DUF1712_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000278849" description="Vacuolar fusion protein CCZ1">
        <location>
            <begin position="1"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P38273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="679" mass="78350" checksum="DC883BFCF44ADDAA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX77</accession>
    <name>Q6FX77_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Vacuolar protein sorting-associated protein VTA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0B01144g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX77"/>
    <dbReference type="FunCoup" id="Q6FX77">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX77"/>
    <dbReference type="KEGG" id="cgr:2886556"/>
    <dbReference type="CGD" id="CAL0127836">
        <property type="gene designation" value="CAGL0B01144g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01144g"/>
    <dbReference type="eggNOG" id="ENOG502RXP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063501_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX77"/>
    <dbReference type="OMA" id="YCKIYVL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990621">
        <property type="term" value="C:ESCRT IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0127836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG57919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="43853" checksum="0C27483D62DC2448" modified="2004-07-19" version="1">MDSGSVRLVATAQDMERAGLAVVAYYLRLYAVEKLLQLSERSDEVTEAATMLLDQIETFKQEVTGSEDSEADGVKVLLQDSKKAMVYMLNFAMSLYNDKLKQVQDGPWDLTLKRGLWCCIDLFTCVIHLWQSDLQDLSKVAERVKYCKIYLSKMAKGELQKQEAEPNDEELDKELDNLVTDTAKEESGEEKPQELDYADFLGGDDESNDVPLDKSEEEEVNKLVGDSQDNAVTEDDVDDLINKLKMADEDSENEPDDLYRSQADENGGSEEPSNLGLPDTPANIPSRKLDTPAFVDSSDEDQGSDADVEEKDDAVEPVVHTSSTPMEQELEELETSKPTYTKNDLANMMDKADKIEKIQRFAKYAISALNYEDISTARDELTKALELLNTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX94</accession>
    <name>Q6FX94_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphotransferase</fullName>
            <ecNumber evidence="1">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0B00726g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX94"/>
    <dbReference type="SMR" id="Q6FX94"/>
    <dbReference type="STRING" id="284593.Q6FX94"/>
    <dbReference type="KEGG" id="cgr:2886595"/>
    <dbReference type="CGD" id="CAL0127806">
        <property type="gene designation" value="CAGL0B00726g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B00726g"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660553_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX94"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase C-terminal" evidence="2">
        <location>
            <begin position="235"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG57902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="416" mass="47884" checksum="B6286DD23669DAB7" modified="2004-07-19" version="1">MAFHEFHSQQQLKLDKEVQSIIDKFEINQVKLIKLCNEYTDSLQTFKVNHLFGTGQEAGDVVLAYLQRPFFKICLVRVNFNNSQILHQQCNKISQELFNSEHQLAERMCAYTLMFLRLYLPHLYDTPFILPFIVQDYPVRYYSLPVKYQRLLQLAGIYNVQVKVTSESLASLNYTNYSTYFMGASKNINLIASCFIGETYCSCIRVTNSKAGLLDFRIPLTKLPKTDFDFHTIDRFDKLITSDHISETVRNCLIFLHSRRQILSKYHSLCDLPNCIKSHFKLDTDTMAHIVLDESEKLSIANLVMLQQWELETNTNDRQVIKKIVKAVIKRSATLSAIPIVVEIMNHIKHLKEQNETFQSATIGCNGSLIEIFPDYNKYFSETLANSPLGPDIAKKINVTTNMEAIEIGGACLVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXL7</accession>
    <name>Q6FXL7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0B04785g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXL7"/>
    <dbReference type="FunCoup" id="Q6FXL7">
        <property type="interactions" value="461"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXL7"/>
    <dbReference type="KEGG" id="cgr:2886654"/>
    <dbReference type="CGD" id="CAL0127862">
        <property type="gene designation" value="CAGL0B04785g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04785g"/>
    <dbReference type="eggNOG" id="KOG3038">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023535_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FXL7"/>
    <dbReference type="OMA" id="VGRSYWT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140671">
        <property type="term" value="C:ADA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072742">
        <property type="term" value="P:SAGA complex localization to transcription regulatory region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000055">
        <property type="entry name" value="SAGA complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="124"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0127862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="266" mass="29904" checksum="F601FE0D84A05E18" modified="2004-07-19" version="1">MDGQWDLVISSLQDIYNANEVTAFDEDMEMKKLNFENLELAQLDEYFDKFQEHKENIRRAHRLLETVRTNLATVIENTEPSQSAAGTPGPNHSEEVTPGGSGAAANAVATGPLGKLYWISQFCSNEPIYLHSEVAYKPKKGNIDGEWFQCEVVKISSDGMRFEVMDPEPDEQGKTGKVFKCSWKDLLLIPPETTPRSKIPNYPPGTQVLARYPETTTFYPAVVIGNKRDGTCRLRFDGEEDAEKETEVPRRLVLPSPMISAFPTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXN2</accession>
    <name>Q6FXN2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0B04433g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXN2"/>
    <dbReference type="FunCoup" id="Q6FXN2">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886648"/>
    <dbReference type="CGD" id="CAL0127900">
        <property type="gene designation" value="CAGL0B04433g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04433g"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FXN2"/>
    <dbReference type="OMA" id="CGTDMSA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015505">
        <property type="term" value="F:uracil:monoatomic cation symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0127900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="75182" checksum="DFEFFC705D691873" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXR8</accession>
    <name>ATG8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Autophagy-related ubiquitin-like modifier ATG8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATG8</name>
        <name type="synonym">AUT7</name>
        <name type="ordered locus">CAGL0A04675g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin-like modifier involved in autophagosome formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Autophagosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">The C-terminal 2 residues are removed to expose Gly-116 at the C-terminus. The C-terminal Gly is then amidated with phosphatidylethanolamine by an activating system similar to that for ubiquitin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444971.1">
        <property type="nucleotide sequence ID" value="XM_444971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXR8"/>
    <dbReference type="SMR" id="Q6FXR8"/>
    <dbReference type="FunCoup" id="Q6FXR8">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXR8"/>
    <dbReference type="EnsemblFungi" id="CAGL0A04675g-T">
        <property type="protein sequence ID" value="CAGL0A04675g-T-p1"/>
        <property type="gene ID" value="CAGL0A04675g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886410"/>
    <dbReference type="KEGG" id="cgr:2886410"/>
    <dbReference type="CGD" id="CAL0126897">
        <property type="gene designation" value="CAGL0A04675g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_A04675g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04675g"/>
    <dbReference type="eggNOG" id="KOG1654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119276_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FXR8"/>
    <dbReference type="OMA" id="AVYQEHK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120095">
        <property type="term" value="C:vacuole-isolation membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008429">
        <property type="term" value="F:phosphatidylethanolamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071211">
        <property type="term" value="P:protein targeting to vacuole involved in autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905153">
        <property type="term" value="P:regulation of membrane invagination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000017212" description="Autophagy-related protein 8">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000017213" description="Removed in mature form" evidence="1">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by ATG4" evidence="1">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="Phosphatidylethanolamine amidated glycine" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="118" mass="13795" checksum="9684FF0B6C08D450" modified="2004-07-19" version="1" precursor="true">MKSSFKSEYPFEKRKAESERISEKFQNRIPVICEKAEKSDIPEVDKRKYLVPADLTVGQFVYVIRKRIMLPPEKAIFIFVNDTLPPTASLMSQVYQEHKDKDGFLYVTYSGENTFGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXU5</accession>
    <name>Q6FXU5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Plasma membrane ATPase</fullName>
            <ecNumber evidence="17">7.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PMA1</name>
        <name evidence="20 21" type="ordered locus">CAGL0A00495g</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>ATP + H2O + H(+)(in) = ADP + phosphate + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:20852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Cell membrane</location>
            <topology evidence="2 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.1" evidence="17"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444794.1">
        <property type="nucleotide sequence ID" value="XM_444794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXU5"/>
    <dbReference type="FunCoup" id="Q6FXU5">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXU5"/>
    <dbReference type="GeneID" id="2886465"/>
    <dbReference type="KEGG" id="cgr:2886465"/>
    <dbReference type="CGD" id="CAL0126953">
        <property type="gene designation" value="PMA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A00495g"/>
    <dbReference type="eggNOG" id="KOG0205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_0_1"/>
    <dbReference type="InParanoid" id="Q6FXU5"/>
    <dbReference type="OMA" id="VIEFHPF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904949">
        <property type="term" value="C:ATPase complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000011">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000005">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000008">
        <property type="entry name" value="Plasma membrane ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="14 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="306"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="743"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="809"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="842"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="50"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0126953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG57685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="902" mass="98376" checksum="9AF149A058DDBE12" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXZ3</accession>
    <name>Q6FXZ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TRP5</name>
        <name evidence="15 16" type="ordered locus">CAGL0A01430g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444829.1">
        <property type="nucleotide sequence ID" value="XM_444829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXZ3"/>
    <dbReference type="FunCoup" id="Q6FXZ3">
        <property type="interactions" value="519"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXZ3"/>
    <dbReference type="GeneID" id="2886466"/>
    <dbReference type="KEGG" id="cgr:2886466"/>
    <dbReference type="CGD" id="CAL0126805">
        <property type="gene designation" value="TRP5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01430g"/>
    <dbReference type="eggNOG" id="KOG1395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FXZ3"/>
    <dbReference type="OMA" id="VDTARHS"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="348"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0126805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG57722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="707" mass="76530" checksum="BBAFAFC35F018ABE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY11</accession>
    <name>Q6FY11_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0A01914g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FY11">
        <property type="interactions" value="1323"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY11"/>
    <dbReference type="KEGG" id="cgr:2886440"/>
    <dbReference type="CGD" id="CAL0126589">
        <property type="gene designation" value="CAGL0A01914g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01914g"/>
    <dbReference type="eggNOG" id="KOG0889">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000129_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FY11"/>
    <dbReference type="OMA" id="CLDLYGQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000044">
        <property type="entry name" value="NuA4 histone acetyltransferase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="DDR_Repair_Kinase"/>
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        <property type="entry name" value="FATC_dom"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2617"/>
            <end position="3172"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3374"/>
            <end position="3731"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3711"/>
            <end position="3743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0126589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG57742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3743" mass="432440" checksum="A4FF0F5AFB8C32FF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY81</accession>
    <name>Q6FY81_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Histone deacetylase</fullName>
            <ecNumber evidence="2 9">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HOS2</name>
        <name evidence="14 15" type="ordered locus">CAGL0A03322g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 9"/>
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        <property type="protein sequence ID" value="CAG57805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_444912.1"/>
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    <dbReference type="STRING" id="284593.Q6FY81"/>
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    <dbReference type="KEGG" id="cgr:2886391"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A03322g"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_4_1"/>
    <dbReference type="InParanoid" id="Q6FY81"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11598">
        <property type="entry name" value="HDAC_Hos2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
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        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="HISTONE DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="45"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0126599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG57805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="450" mass="51467" checksum="B5A5E3C5F501AF98" modified="2004-07-19" version="1">MSGTFSVDSKTKEFQPLYEFGSNYAPRVSYHINPEVSHYHYGVRHPMKPFRLMLTDHLVSGYGLHKIMDLYKTRKATAEEMEEFHSEDYVNFLSKVTPENLSKLPRGTLEKFNIGDDCPIFPNIFQYSSLYTGASLDASRKLINNQSDIAINWSGGLHHAKKNSPSGFCYINDIVLAILNLLRYHPRVLYIDIDLHHGDGVQEAFYTTDRVYTISFHKYNGEFFPGTGKNDETGCADGKHFAMNVPLEDGIDDDSYINLFKSIIDPLITTFKPTVILQQCGADSLGHDRLGCFNLNIKAHGECVKFVRSFGIPMLVVGGGGYTPRNVSRLWTYETGILNNVLLPEELPDNLPFKESFGPDYSLYPVLDNLYENRNSKKFLEDIRIRCLENIRFLQGAPSVRMDAENIPTQDISGLTEEEEELIKEMNEEDEDWRLQEIEKENAKMMELIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-03-19" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>W0TYL6</accession>
    <name>W0TYL6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAGL0F09273g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="W0TYL6"/>
    <dbReference type="STRING" id="284593.W0TYL6"/>
    <dbReference type="KEGG" id="cgr:2887803"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F09273g"/>
    <dbReference type="HOGENOM" id="CLU_1703983_0_0_1"/>
    <dbReference type="InParanoid" id="W0TYL6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021031">
        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Hyphally-regulated cell wall protein N-terminal" evidence="5">
        <location>
            <begin position="43"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="154" mass="17413" checksum="6E35872651AD2E29" modified="2014-03-19" version="1">MKSTHQKGQKFCVNNVCASKMRKKQLSSTWIFYIIQLCYHLSLATSQAVVQSNTIVYGNNPPEYDNGYIVLGGAYLAFQDMTTVAMYDTVKVQKGGALYYLNNGLDGFNIISENHILGFFNFENNGTVVVDDRNSTTAGTWKIDNHLFSYQFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN02</accession>
    <name>B4UN02_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA-directed DNA polymerase</fullName>
            <ecNumber evidence="4">2.7.7.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">CAGL0G07183g2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Integrase (IN) targets the VLP to the nucleus, where a subparticle preintegration complex (PIC) containing at least integrase and the newly synthesized dsDNA copy of the retrotransposon must transit the nuclear membrane. Once in the nucleus, integrase performs the integration of the dsDNA into the host genome.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Reverse transcriptase/ribonuclease H (RT) is a multifunctional enzyme that catalyzes the conversion of the retro-elements RNA genome into dsDNA within the VLP. The enzyme displays a DNA polymerase activity that can copy either DNA or RNA templates, and a ribonuclease H (RNase H) activity that cleaves the RNA strand of RNA-DNA heteroduplexes during plus-strand synthesis and hydrolyzes RNA primers. The conversion leads to a linear dsDNA copy of the retrotransposon that includes long terminal repeats (LTRs) at both ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 22 23">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="4"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAR58026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="B4UN02">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UN02"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000384_38_1_1"/>
    <dbReference type="InParanoid" id="B4UN02"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09274">
        <property type="entry name" value="RNase_HI_RT_Ty3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01647">
        <property type="entry name" value="RT_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.70:FF:000001">
        <property type="entry name" value="Retrovirus-related Pol polyprotein from transposon gypsy-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000020">
        <property type="entry name" value="Transposon Tf2-6 polyprotein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050951">
        <property type="entry name" value="Retrovirus_Pol_polyprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041373">
        <property type="entry name" value="RT_RNaseH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984">
        <property type="entry name" value="PROTEIN CBG26694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37984:SF5">
        <property type="entry name" value="PROTEIN NYNRIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17917">
        <property type="entry name" value="RT_RNaseH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="18">
        <location>
            <begin position="541"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="19">
        <location>
            <begin position="1117"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAR58026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1504" mass="174572" checksum="97FC66A24EAF9EDD" modified="2008-09-23" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN59</accession>
    <name>B4UN59_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M07001g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAR58075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN59"/>
    <dbReference type="FunCoup" id="B4UN59">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:9488058"/>
    <dbReference type="CGD" id="CAL0136747">
        <property type="gene designation" value="CAGL0M07001g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07001g"/>
    <dbReference type="HOGENOM" id="CLU_173479_2_0_1"/>
    <dbReference type="InParanoid" id="B4UN59"/>
    <dbReference type="OMA" id="ICNIYRQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1840.10">
        <property type="entry name" value="YNR034W-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021591">
        <property type="entry name" value="YNR034W-A/EGO2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035098">
        <property type="entry name" value="YNR034W-A/EGO2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11503">
        <property type="entry name" value="YNR034W-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160683">
        <property type="entry name" value="YNR034W-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0136747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR58075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8308" checksum="A998308FFE4F7423" modified="2008-09-23" version="1">MLSSKLQELLPGSVGVMTFDSNNNLVLADGVAKDKVNDIPELSEVQCNAEGVAVLENGDYIVHVCKKDGNTLVVYTGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1999-07-15" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>O74684</accession>
    <name>KNH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Cell wall synthesis protein KNH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">KNH1</name>
        <name type="ordered locus">CAGL0H07997g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="J. Bacteriol." volume="180" first="5020" last="5029">
            <title>Isolation of Candida glabrata homologs of the Saccharomyces cerevisiae KRE9 and KNH1 genes and their involvement in cell wall beta-1,6-glucan synthesis.</title>
            <authorList>
                <person name="Nagahashi S."/>
                <person name="Lussier M."/>
                <person name="Bussey H."/>
            </authorList>
            <dbReference type="PubMed" id="9748432"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell wall beta(1-&gt;6) glucan synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">O-glycosylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the KRE9/KNH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AF064252">
        <property type="protein sequence ID" value="AAC64009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447146.1">
        <property type="nucleotide sequence ID" value="XM_447146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O74684"/>
    <dbReference type="FunCoup" id="O74684">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="284593.O74684"/>
    <dbReference type="EnsemblFungi" id="CAGL0H07997g-T">
        <property type="protein sequence ID" value="CAGL0H07997g-T-p1"/>
        <property type="gene ID" value="CAGL0H07997g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888825"/>
    <dbReference type="KEGG" id="cgr:2888825"/>
    <dbReference type="CGD" id="CAL0129512">
        <property type="gene designation" value="KNH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H07997g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07997g"/>
    <dbReference type="eggNOG" id="ENOG502S28F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063732_1_0_1"/>
    <dbReference type="InParanoid" id="O74684"/>
    <dbReference type="OMA" id="YYYFQIY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008659">
        <property type="entry name" value="Kre9/Knh1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05390">
        <property type="entry name" value="Kre9_KNH1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000016850" description="Cell wall synthesis protein KNH1">
        <location>
            <begin position="15"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="9748432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="265" mass="29047" checksum="6A13BCD6BC0AE2BC" modified="1998-11-01" version="1" precursor="true">MLSIILLLMQLVAADIAVVGPSLDQSFDASGGTAKIPIQWLFTPNTPSQDDFTSLTFSLCSGPNYKIEAFKVIGKLSDIGTTDFEAEVSQSVGANGYYYVQIYAATTDGYTIHYSPRFKLTGMTGSKLPDTLLITAPPTPETRVTTGDLGATIDSKSFDIPYGEQNGKAKFAPMQTQPGTKITATTWSRRYATSAVSFFTSLTATPVQHTTLTPGWSYYISSDYNYAPPAPFPSDNGGWYDPKKRQSFTTRKLNMDKLRKRRQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIZ3</accession>
    <name>Q6FIZ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAGL0M10439g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIZ3"/>
    <dbReference type="FunCoup" id="Q6FIZ3">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIZ3"/>
    <dbReference type="CAZy" id="GH37">
        <property type="family name" value="Glycoside Hydrolase Family 37"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891365"/>
    <dbReference type="eggNOG" id="KOG0602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006451_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FIZ3"/>
    <dbReference type="OMA" id="WLFMMTK"/>
    <dbReference type="PHI-base" id="PHI:11138"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000026">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="7">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="765" mass="87003" checksum="CC97DA5F134DA378" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIZ5</accession>
    <name>Q6FIZ5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M10395g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449799.1">
        <property type="nucleotide sequence ID" value="XM_449799.1"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIZ5"/>
    <dbReference type="KEGG" id="cgr:2891363"/>
    <dbReference type="CGD" id="CAL0136915">
        <property type="gene designation" value="CAGL0M10395g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M10395g"/>
    <dbReference type="HOGENOM" id="CLU_241997_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIZ5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1665" mass="188316" checksum="A3AE97A0674C59A0" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ65</accession>
    <name>Q6FJ65_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Heat shock protein 78, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HSP78</name>
        <name evidence="10 11" type="ordered locus">CAGL0M08822g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449729.1">
        <property type="nucleotide sequence ID" value="XM_449729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ65"/>
    <dbReference type="FunCoup" id="Q6FJ65">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ65"/>
    <dbReference type="GeneID" id="2891290"/>
    <dbReference type="KEGG" id="cgr:2891290"/>
    <dbReference type="CGD" id="CAL0136887">
        <property type="gene designation" value="HSP78"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08822g"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ65"/>
    <dbReference type="OMA" id="VSKMMQG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="112"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="509"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="682"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="324"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0136887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="88895" checksum="553CA6F174EAECFC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ78</accession>
    <name>Q6FJ78_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M08536g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_449716.1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08536g"/>
    <dbReference type="eggNOG" id="ENOG502RR6Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056775_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ78"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0136465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="408" mass="45239" checksum="CEDE1DEFCDD5D44E" modified="2004-07-19" version="1">MSRCLSKSLRDYLAWVNLPVARSNFFITYDYRLRHQRQQNALTADLLRSVATCLAKYLLVDYKLNEYPYYDLTVVNVFSNYRQSMEILSAAMRYLEPVVDRQLLSRVKVYMMPLYPSPQHPGETRQVSENVWVLGDDQAVFGTPATLQDMRLADLLPLEYSTASSIAEEDPVHVVMFDDVLQNLAPDLVRVRPDCGNVNTSAGAGGSASGSASAGEWEQCFVNTSDMSRTYLGQGMGMDPLCELAVQLCLPPAENVACGTEVYVPSQAALLFSHLKRRFPEHKLFAVDSFEVTHETMYFRWKSWLAAIMGFGTRGITGTGTGSASAPYGIESSSLVLGYTSGTGTSTSYSHRALKLVPNAHQCQLLYTGINDGRKACTVEPLDTFIDKWRGSDLPAPEAGPFSVMYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ84</accession>
    <name>Q6FJ84_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein/NADH dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0M08382g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ84"/>
    <dbReference type="FunCoup" id="Q6FJ84">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ84"/>
    <dbReference type="KEGG" id="cgr:2891269"/>
    <dbReference type="CGD" id="CAL0136261">
        <property type="gene designation" value="CAGL0M08382g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08382g"/>
    <dbReference type="eggNOG" id="ENOG502S1AY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141769_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ84"/>
    <dbReference type="OMA" id="QNHNGHM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="5">
        <location>
            <begin position="40"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0136261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="135" mass="15253" checksum="7EB86770DBB1524D" modified="2004-07-19" version="1">MSKVARQLKFLNKISSTTTDAQVILSPGKYQRLSLTFQTKNHNGHMGARKFWKDYLPTIQFYNPQLRIDVTRIKNESKTVSVPCTLQAIGTDGKVVEEIDMSNKHAPEILQSLLQKLDHERVPESQIISVGTQSA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ91</accession>
    <name>LST4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein LST4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LST4</name>
        <name type="ordered locus">CAGL0M08228g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in extracellular amino acid uptake. Required for the protein trafficking from the Golgi to the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LST4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449703.1">
        <property type="nucleotide sequence ID" value="XM_449703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ91"/>
    <dbReference type="SMR" id="Q6FJ91"/>
    <dbReference type="FunCoup" id="Q6FJ91">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ91"/>
    <dbReference type="EnsemblFungi" id="CAGL0M08228g-T">
        <property type="protein sequence ID" value="CAGL0M08228g-T-p1"/>
        <property type="gene ID" value="CAGL0M08228g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891262"/>
    <dbReference type="KEGG" id="cgr:2891262"/>
    <dbReference type="CGD" id="CAL0137017">
        <property type="gene designation" value="CAGL0M08228g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08228g"/>
    <dbReference type="eggNOG" id="ENOG502QPJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010482_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ91"/>
    <dbReference type="OMA" id="SEYDEYP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990877">
        <property type="term" value="C:FNIP-folliculin RagC/D GAP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037545">
        <property type="entry name" value="DENN_FNIP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041153">
        <property type="entry name" value="LST4_longin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18639">
        <property type="entry name" value="Longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51836">
        <property type="entry name" value="DENN_FNIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0029">Amino-acid transport</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000324405" description="Protein LST4">
        <location>
            <begin position="1"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="domain" description="uDENN FNIP1/2-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="cDENN FNIP1/2-type" evidence="2">
        <location>
            <begin position="231"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="dDENN FNIP1/2-type" evidence="2">
        <location>
            <begin position="731"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="314"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="840" mass="94150" checksum="53469A6AD21A6095" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJD3</accession>
    <name>Q6FJD3_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M07205g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJD3"/>
    <dbReference type="KEGG" id="cgr:2891710"/>
    <dbReference type="CGD" id="CAL0137053">
        <property type="gene designation" value="CAGL0M07205g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07205g"/>
    <dbReference type="HOGENOM" id="CLU_1151662_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJD3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="241" mass="27278" checksum="88947CF94F090F9E" modified="2004-07-19" version="1">MTRPPVLQYGIPFGVTVGAWKSLRKYLGHRMPYSSLHEPSQFEQWADDFFVPETLQEKIIEHIPEPVKHNKLSELFEQVTQRFFDMDTRLSIIMLIVIVLAPLLSPSRKETHENCNDNENELQQSTAEERLKSAETTAVDLDEQEKEIHMEEIEDSTVVAVKLPVATAEEVELMHETFGAVPALKREPNPSHTASSSSLDSANSKLSRESPRVPLQVSPAKACNSNAQINNFQAYSQPFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJJ7</accession>
    <name>Q6FJJ7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosome subunit biogenesis protein NIP7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M05775g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with pre-ribosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NIP7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJJ7"/>
    <dbReference type="FunCoup" id="Q6FJJ7">
        <property type="interactions" value="1174"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJJ7"/>
    <dbReference type="KEGG" id="cgr:2891645"/>
    <dbReference type="CGD" id="CAL0137363">
        <property type="gene designation" value="CAGL0M05775g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05775g"/>
    <dbReference type="eggNOG" id="KOG3492">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097217_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJJ7"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0137363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="181" mass="20478" checksum="88A48CA00EC69D72" modified="2004-07-19" version="1">MRQLTEEETKVVFEKLAGYIGRNIAYLVDNKEVPHVFRLQKDRVYYVPEYIAKLATSVARQNLMSVGICLGKFTKTGKFRLHITALSVLAKHAKYKIWIKPNGEMPFLYGNHVLKAHVGKMTDDIPEHAGLIVFSMNDMPLGFGVSAKSTLESKNLQPTAIVAFRQADIGEYLRDEDTLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJR6</accession>
    <name>Q6FJR6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein KRE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KRE1</name>
        <name evidence="4 5" type="ordered locus">CAGL0M04169g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449528.1">
        <property type="nucleotide sequence ID" value="XM_449528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJR6"/>
    <dbReference type="STRING" id="284593.Q6FJR6"/>
    <dbReference type="GeneID" id="2891537"/>
    <dbReference type="KEGG" id="cgr:2891537"/>
    <dbReference type="CGD" id="CAL0137067">
        <property type="gene designation" value="KRE1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04169g"/>
    <dbReference type="eggNOG" id="ENOG502S1TV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741847_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJR6"/>
    <dbReference type="OMA" id="RAPTSMW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031452">
        <property type="entry name" value="Kre1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17056">
        <property type="entry name" value="KRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012791106" description="Protein KRE1" evidence="3">
        <location>
            <begin position="16"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0137067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="38396" checksum="8151984834FB6E48" modified="2004-07-19" version="1">MRISRLLLIAGVAQAAIVTDFIITTLADGTLSTVTSIYDNAKPKTDTDTDTDTDTDTDTNTATGTTKATTTNTNTNTNTNTGTNTGVKLITTSTVVTDAAGVIKTVPTVITSGVKQTGTTTGTTTGTTTGTTTGTTGTKKSYVSTITTVDAAGRPVTLTTTITGTNTNTNTNTNTGTANTPYVTTITTTNINGVTVTLTQTVTPTKAAVDPAAANGALTAFVVKSKPSDLVGTAPDGRPDPSLVSFTEVPATPVTTVPIDTYITITEGTTRTYTTLRVPTSIWVTITNAAGQTVTFQTTYMQRFSSQYLEVASPSSGSIGLGSLQGEVGVVKSVMVMSQSANAAHNNARAGTPVTSICMSLAMAFLTMFTWFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJT8</accession>
    <name>Q6FJT8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MIOREX complex component 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M03685g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="cgr:2891516"/>
    <dbReference type="CGD" id="CAL0137085">
        <property type="gene designation" value="CAGL0M03685g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03685g"/>
    <dbReference type="eggNOG" id="ENOG502R6CM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_555750_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJT8"/>
    <dbReference type="OMA" id="PVIPWDA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="Pet20-like"/>
    </dbReference>
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        <property type="entry name" value="Pet20"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="57419" checksum="F851ACDE212A5500" modified="2004-07-19" version="1">MSLVNSRQYRIMRFVPRICRQYRQFSQGRRKSGAVLKEKENTEVKLQDNTTALNGVVNDADLLEPSGGDKTSETKWKRELKKDISSAKKPTTLVPSVSSTDHLTDQEIHLEGLFAGSKPLFLGKLASMKSMPSFFDNGVLLSKNFRVINASDDGGEKSLDEFLESVKDNDWNIDNSEQKKVIPWQASISGIEYEDKSFSNIPKHVLSKLRPYKLIKLKMPKIVNKQRRASMIKNLKFHNNKVNDELHLVDIFGKPHERDIAKHQLGAASAELDSNMSKEQISAKREHFKELMYYYHRYGFIKSDCDQYKTYVDKQSKLAQKEFQKVTGLVIKPGRSDFCLPLHLYVNKRQNSKILLERYLRKKLYRDVISVMLNFSSNISDQSMIKRFKKKLYNIQEETIRDLTNILPSTEFEALEADCCIMKSPVSGFKRMHWLKYSKRHNVMWGKNYSKEFNVSGNSFALTRSGVRRMKYPVYINWTTYDSTFRAWNHYNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJV2</accession>
    <name>Q6FJV2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enhancer of mRNA-decapping protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M03333g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EDC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJV2"/>
    <dbReference type="FunCoup" id="Q6FJV2">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJV2"/>
    <dbReference type="KEGG" id="cgr:2891500"/>
    <dbReference type="CGD" id="CAL0137009">
        <property type="gene designation" value="CAGL0M03333g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03333g"/>
    <dbReference type="eggNOG" id="KOG2585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037134_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJV2"/>
    <dbReference type="OMA" id="AMFDKKS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900153">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22576">
        <property type="entry name" value="Edc3_Lsm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DFDF" evidence="7">
        <location>
            <begin position="124"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="6">
        <location>
            <begin position="348"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="61"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="635" mass="70419" checksum="89057B282717DA85" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJX7</accession>
    <name>Q6FJX7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TBF1</name>
        <name evidence="6 7" type="ordered locus">CAGL0M02761g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449467.1">
        <property type="nucleotide sequence ID" value="XM_449467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJX7"/>
    <dbReference type="FunCoup" id="Q6FJX7">
        <property type="interactions" value="622"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJX7"/>
    <dbReference type="GeneID" id="2891475"/>
    <dbReference type="KEGG" id="cgr:2891475"/>
    <dbReference type="CGD" id="CAL0136313">
        <property type="gene designation" value="TBF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02761g"/>
    <dbReference type="eggNOG" id="ENOG502QRT9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008791_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FJX7"/>
    <dbReference type="OMA" id="IQEQQIH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043035">
        <property type="term" value="F:chromatin insulator sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032211">
        <property type="term" value="P:negative regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001015">
        <property type="term" value="P:snoRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000137">
        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="425"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="4">
        <location>
            <begin position="425"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0136313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="525" mass="59133" checksum="7F4131634EECB0D2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK05</accession>
    <name>Q6FK05_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M02145g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK05"/>
    <dbReference type="FunCoup" id="Q6FK05">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK05"/>
    <dbReference type="KEGG" id="cgr:2891765"/>
    <dbReference type="CGD" id="CAL0136901">
        <property type="gene designation" value="CAGL0M02145g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02145g"/>
    <dbReference type="eggNOG" id="KOG2730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029658_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FK05"/>
    <dbReference type="OMA" id="KALCIYY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017126">
        <property type="term" value="P:nucleologenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="333" mass="38229" checksum="1CA4DB12B2543AAA" modified="2004-07-19" version="1">MGPGLAVEIRRGLTATTMAHRKWLVRGSDLRKDILRKSSKRYRKYGRSKKCFKELVQLLLKDEFLVDNNKPPSSKAGTQKELVKYWRKRRTLFSKVNSMPIYMTSELWFSVTPERIARFLANFISACLPNAKRILDVFSGGGGNSIQFANVFDRVYCLDSNLEHLYCSIKNGQSYGVSNKLWMCKGKWGEHTAKKFRKLNIDCIFGSPPWGGPEYIKDEKYDLEKSLLPFGLYKLLKTFKIVSDNIILFLPKNSNLDQLSETTKEVFGPEAKCKVLYIKEQGYLKGMLCLWGSAFTNYQQDTASDSEEEEGEELNESDKSKNANIYINYDIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK20</accession>
    <name>Q6FK20_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cell wall protein ECM33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ECM33</name>
        <name evidence="14 15" type="ordered locus">CAGL0M01826g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449424.1">
        <property type="nucleotide sequence ID" value="XM_449424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK20"/>
    <dbReference type="SMR" id="Q6FK20"/>
    <dbReference type="STRING" id="284593.Q6FK20"/>
    <dbReference type="GeneID" id="2891194"/>
    <dbReference type="KEGG" id="cgr:2891194"/>
    <dbReference type="CGD" id="CAL0137351">
        <property type="gene designation" value="ECM33"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01826g"/>
    <dbReference type="eggNOG" id="ENOG502QUZC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035846_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK20"/>
    <dbReference type="OMA" id="DKFQCED"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.20.20:FF:000016">
        <property type="entry name" value="Cell wall protein ECM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.20.20">
        <property type="entry name" value="Receptor L-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036941">
        <property type="entry name" value="Rcpt_L-dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274032" description="Cell wall protein ECM33" evidence="13">
        <location>
            <begin position="18"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="356"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0137351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG62400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="43063" checksum="1A93B0A4FDB2EF18" modified="2004-07-19" version="1">MKVTSLVYAAMATSVLGQNSTSDDVPSGCSLGSSATATAQSDLDKYSGCETIVGNLTITGALGSAALAGVKKIDGSLRIYNATSLGSFAADSVKEITGALNMQDLTILTTASFGALEEVDTINLITLPAISTFNTNLQSANNIVVSDTSLESVEGFGSLKEVNVLNINNNRYLNSFKSSLESVSGALQFASNADETAVSFDNLIWANNITLRDVQNASFAKLESVNASLGFINNTISTLNLTHLSKVGQSLSVVSNDDLTQLSFLNLTSVGGGLVVANNTNLKTIDGLKNVQTVGGAIDITGNFTTLDLSSLKSVRGGATFNTVSGNFSCSPLKSLQSKGAIQGDSFVCKNGATSTSISMSSRSRSSSASSSASATVTARSNDTASTSSTKTKKSKGAAAQEVFPAGSFFGAVAAVAVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK53</accession>
    <name>Q6FK53_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ethionine resistance-conferring protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M01078g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449391.1">
        <property type="nucleotide sequence ID" value="XM_449391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK53"/>
    <dbReference type="FunCoup" id="Q6FK53">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK53"/>
    <dbReference type="KEGG" id="cgr:2891161"/>
    <dbReference type="CGD" id="CAL0136291">
        <property type="gene designation" value="CAGL0M01078g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01078g"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FK53"/>
    <dbReference type="OMA" id="KISHHHI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="669"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="695" mass="77898" checksum="6F3EE80DE7964F4A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-06-16" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKA3</accession>
    <name>RFU1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Regulator of free ubiquitin chains 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RFU1</name>
        <name type="ordered locus">CAGL0L13156g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Inhibitor of the DOA4 deubiquitinase involved in the regulation of protein degradation by the proteasome and maintenance of a normal level of free ubiquitin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RFU1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449341.1">
        <property type="nucleotide sequence ID" value="XM_449341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKA3"/>
    <dbReference type="SMR" id="Q6FKA3"/>
    <dbReference type="FunCoup" id="Q6FKA3">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKA3"/>
    <dbReference type="EnsemblFungi" id="CAGL0L13156g-T">
        <property type="protein sequence ID" value="CAGL0L13156g-T-p1"/>
        <property type="gene ID" value="CAGL0L13156g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890591"/>
    <dbReference type="KEGG" id="cgr:2890591"/>
    <dbReference type="CGD" id="CAL0135822">
        <property type="gene designation" value="CAGL0L13156g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L13156g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L13156g"/>
    <dbReference type="eggNOG" id="ENOG502S3ZX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1348926_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKA3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0646">Protease inhibitor</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="chain" id="PRO_0000376813" description="Regulator of free ubiquitin chains 1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="203" mass="23706" checksum="39F786E409293996" modified="2004-07-19" version="1">MKSTQQLGQEAREFEFNPNIPLHLYLKTCVTLLNNASECFQRGDKSLSYFYYFRYVDLCTNKLPNHPTIRSTSTGLDNDSKLYVQEYKQLLRLEVPHILKIMEELKTELDAMYERHKVSLANNIASPISYKHNNRMDALLHDYYTERGCTGHSMQHKTSLHKNENFNERINLMKDSFMGRAPNGSQEVRNVSNTFYPDLPTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKL6</accession>
    <name>Q6FKL6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0L10604g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKL6"/>
    <dbReference type="FunCoup" id="Q6FKL6">
        <property type="interactions" value="939"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKL6"/>
    <dbReference type="KEGG" id="cgr:2891039"/>
    <dbReference type="CGD" id="CAL0135898">
        <property type="gene designation" value="CAGL0L10604g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10604g"/>
    <dbReference type="eggNOG" id="KOG1666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075474_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKL6"/>
    <dbReference type="OMA" id="MEYEAND"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007036">
        <property type="term" value="P:vacuolar calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF26">
        <property type="entry name" value="VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="132"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0135898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG62202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="225" mass="25409" checksum="0F3D1C0EF38F247F" modified="2004-07-19" version="1">MSLLVSYESDFKATLDQGKAALVKASAQSLPERNATLKQIEEQKDELYDLLDQMALEVNNSVSDMQQRANYKAKIRDWKTQVNQELKEPLQKLLDTRDKDELFGAAARSGANGNIDVEGMSEEQRQQLLSNHAILQKSGDKLRDASRLANETEGIGSQIMMDLRSQRETLENARDTLFQADSYVDKSIKTLKVMSRRLIANKAISYAIIAVLILLIILVIFSKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKN7</accession>
    <name>Q6FKN7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein MTH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L10043g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKN7"/>
    <dbReference type="FunCoup" id="Q6FKN7">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891054"/>
    <dbReference type="CGD" id="CAL0135716">
        <property type="gene designation" value="CAGL0L10043g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10043g"/>
    <dbReference type="eggNOG" id="ENOG502QPKX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049491_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKN7"/>
    <dbReference type="OMA" id="ENANIQH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035189">
        <property type="entry name" value="Std1/Mth1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17235">
        <property type="entry name" value="STD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="51576" checksum="1730787034EE335A" modified="2004-07-19" version="1">MFVSPPPATTTKQVFPKKLPKRLSAIPENNSVSNYSLDNSDNGSIDSDVNMDVDSHISDATTQLQLPLQKTTSNRNDFVSAPPEYADRARLEIKKRLLPSGQTMGHFPTHSSTSRHIQRSRSHSSQSSTSDSQSLFSDNASSYQSSIFSQPSTVFSQNTSSTTNSTHDFLFPHPAKIITQLSLEDALPKSFYDMYAPEILTDPTNLLCNGRPKFTKRELLDWDLNDIRSLLIVEKMKPEWGSQLPEIVTADPNLPKFRFILLPLNSTDETIIQILVNSDLYQEANLDFEFKLTSAKYTVAAARKRHEQLRGYHEEVMQLTKPEWRNIIENYLLNIAVEAQCRFDFKQRCSEFKKWKLQQANLKRPDMPPPSMVPMNHSNKSSGSLLKRALMKNLQLKNMKNEHSQENMMAGPSATPLSNKVLLTKEEKAHIWTQCQTQVYQRLGLDWKPDAMP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKN8</accession>
    <name>DBP5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP5</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP5</name>
        <name type="ordered locus">CAGL0L10021g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Nucleus</location>
            <location>Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Nuclear pore complex cytoplasmic fibrils.</text>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449206.1">
        <property type="nucleotide sequence ID" value="XM_449206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKN8"/>
    <dbReference type="SMR" id="Q6FKN8"/>
    <dbReference type="FunCoup" id="Q6FKN8">
        <property type="interactions" value="837"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKN8"/>
    <dbReference type="EnsemblFungi" id="CAGL0L10021g-T">
        <property type="protein sequence ID" value="CAGL0L10021g-T-p1"/>
        <property type="gene ID" value="CAGL0L10021g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891053"/>
    <dbReference type="KEGG" id="cgr:2891053"/>
    <dbReference type="CGD" id="CAL0135432">
        <property type="gene designation" value="CAGL0L10021g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L10021g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10021g"/>
    <dbReference type="eggNOG" id="KOG0332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKN8"/>
    <dbReference type="OMA" id="IAAETRW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000318">
        <property type="entry name" value="ATP-dependent RNA helicase DDX19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000232220" description="ATP-dependent RNA helicase DBP5">
        <location>
            <begin position="1"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="147"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="325"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="261"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="160"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="504" mass="56684" checksum="4B1272E2CA59C9FB" modified="2004-07-19" version="1">MSATEDKKDPASMLAELKLDKDEGNKTPETKTPESNSAETKTTEEVKELKNPFTQKKEDVENDAAEEKTNEVNKDDAKDERENKDTNLIKSEYEVKVNLADLQADPNSPLYSVKSFDELGLSPELLKGIYAMKFQKPSKIQERALPLLLSNPPRNMIAQSQSGTGKTAAFSLTMLSRVDETQNVPQAICLAPSRELARQTLEVIQEMGKYTKITTQLIVPDSFEKNTKINANVVVGTPGTLLDLIRRKLIQLQNVKIFVLDEADNMLDKQGLGDQCIRVKKFLPKDTQLVLFSATFADAVKAYAQKVIPNANTLELQRNEVNVKAIKQLYMDCNDEAHKYEVLCELYGLLTIGSSIIFVAKKDTANLLYGKLKHEGHQVSILHSDLRTDERDRLIDDFREGRSKVLITTNVLARGIDIPSVSMVVNYDLPTLPNGMPDYATYVHRIGRTGRFGRTGVAISFVHDKKSFKILSAIQDYFKDIELTRVPTDDWDEVEDIVKKVLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKV0</accession>
    <name>Q6FKV0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L08448g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKV0"/>
    <dbReference type="STRING" id="284593.Q6FKV0"/>
    <dbReference type="KEGG" id="cgr:2890619"/>
    <dbReference type="CGD" id="CAL0136104">
        <property type="gene designation" value="CAGL0L08448g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08448g"/>
    <dbReference type="eggNOG" id="ENOG502RZW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098356_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKV0"/>
    <dbReference type="OMA" id="AFMWFLW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="173" mass="19433" checksum="FEF530C17FFADB1C" modified="2004-07-19" version="1">MLAVTDNLLRIVNFVFMVICIGLISDLIATRDRHSSRVNYCMFAAAYGIATDSLYGVFANFFEILAWPLILFTLDFLNFAFMLTAGCVLAVGIRAHSCNNAHYRENNKIIQGSERRCRESQAAVAFFFFSMAIFLAKMIMSLLNIFSNGAFGTKFIRRRRNNAEVGVPSVSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL88</accession>
    <name>Q6FL88_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L05324g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449006.1">
        <property type="nucleotide sequence ID" value="XM_449006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL88"/>
    <dbReference type="KEGG" id="cgr:2890785"/>
    <dbReference type="CGD" id="CAL0135460">
        <property type="gene designation" value="CAGL0L05324g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05324g"/>
    <dbReference type="HOGENOM" id="CLU_2249796_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL88"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="104" mass="11986" checksum="446745282234B980" modified="2004-07-19" version="1">MKPRDHRHPITRIHTICERQKKAEKISEIPSVSGTSAEQCRREAPRSVPTAQRFLPRQPNPHGRQASNGREAIQTIKNKVIKWASMSKLLAPLYWYCCPKKLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL95</accession>
    <name>Q6FL95_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribosomal RNA-processing protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0L05170g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL95"/>
    <dbReference type="FunCoup" id="Q6FL95">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL95"/>
    <dbReference type="KEGG" id="cgr:2890724"/>
    <dbReference type="CGD" id="CAL0135290">
        <property type="gene designation" value="CAGL0L05170g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05170g"/>
    <dbReference type="eggNOG" id="KOG2885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018300_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL95"/>
    <dbReference type="OMA" id="QKKRTDN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15459">
        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="6">
        <location>
            <begin position="219"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="330"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0135290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="52242" checksum="FC5A1B9D383415EC" modified="2004-07-19" version="1">MSDLLEERLRANSSAFDGLMALIPAKYYYDEKTQDQWKMKKKDKSQVRDDKLKKLDPEQQGDEVSSALDVMKKREQNAVPVELPGAKLNKLNKKPVADVDGKHKALGGEVVEEAEDDDEDEEDEDIKVIFDDEGNEIKLGDKQREQRDEPADAEEGEDDNDEVNGEKSTKEVTKKSNEKAKKLKNVEELRSKLQQKIQALKEKRKAPGTNVQGAASSREAILEQRRKREEARKKRKLEHANGGDSDDDDDDDDEDHSSESENEDDLEENPKKKQKKNGVSAKDVMFQNIIFDDGDRTTSDLQRLRKQPNGKKKGPAKNDIKAHLKLLETKQNKIQNKDELEQIKLKEKEKWQKAMLQAEGIRLKDDEKLLKKALKRKEAKKRKSALEWQERKRTVATNIAEKQKRREENLQIRKQNKGQKKNKQQKMKRKFTGSIVPKKRAGFEGRLKSGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLE7</accession>
    <name>Q6FLE7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Malate synthase</fullName>
            <ecNumber evidence="3 11">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MLS1</name>
        <name evidence="15 16" type="ordered locus">CAGL0L03982g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="11">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with PEX9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="3 11"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448947.1">
        <property type="nucleotide sequence ID" value="XM_448947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLE7"/>
    <dbReference type="SMR" id="Q6FLE7"/>
    <dbReference type="FunCoup" id="Q6FLE7">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLE7"/>
    <dbReference type="GeneID" id="2890761"/>
    <dbReference type="KEGG" id="cgr:2890761"/>
    <dbReference type="CGD" id="CAL0135146">
        <property type="gene designation" value="MLS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03982g"/>
    <dbReference type="eggNOG" id="KOG1261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018928_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FLE7"/>
    <dbReference type="OMA" id="DGSWIAH"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="PHI-base" id="PHI:123299"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="12">
        <location>
            <begin position="173"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="14">
        <location>
            <begin position="424"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0135146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG61917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="554" mass="63201" checksum="7F053A12AA3DA579" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-10-13" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLG2</accession>
    <name>RRF2M_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-releasing factor 2, mitochondrial</fullName>
            <shortName evidence="1">RRF2mt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor G 2, mitochondrial</fullName>
            <shortName evidence="1">EF-G2mt</shortName>
            <shortName evidence="1">mEF-G 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MEF2</name>
        <name type="ordered locus">CAGL0L03652g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This protein may be expected to contain an N-terminal transit peptide but none has been predicted.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448932.1">
        <property type="nucleotide sequence ID" value="XM_448932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLG2"/>
    <dbReference type="SMR" id="Q6FLG2"/>
    <dbReference type="FunCoup" id="Q6FLG2">
        <property type="interactions" value="627"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLG2"/>
    <dbReference type="EnsemblFungi" id="CAGL0L03652g-T">
        <property type="protein sequence ID" value="CAGL0L03652g-T-p1"/>
        <property type="gene ID" value="CAGL0L03652g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890538"/>
    <dbReference type="KEGG" id="cgr:2890538"/>
    <dbReference type="CGD" id="CAL0135510">
        <property type="gene designation" value="CAGL0L03652g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03652g"/>
    <dbReference type="eggNOG" id="KOG0465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FLG2"/>
    <dbReference type="OMA" id="GPQFTFP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03059">
        <property type="entry name" value="mEF_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030851">
        <property type="entry name" value="EFG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000385613" description="Ribosome-releasing factor 2, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="21"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="101"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03059"/>
        </source>
    </evidence>
    <sequence length="807" mass="89628" checksum="D18376630441EA0A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLH1</accession>
    <name>Q6FLH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0L03454g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 18">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLH1"/>
    <dbReference type="FunCoup" id="Q6FLH1">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLH1"/>
    <dbReference type="KEGG" id="cgr:2890734"/>
    <dbReference type="CGD" id="CAL0135820">
        <property type="gene designation" value="CAGL0L03454g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03454g"/>
    <dbReference type="eggNOG" id="KOG2108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FLH1"/>
    <dbReference type="OMA" id="FFVAQTR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990986">
        <property type="term" value="P:DNA recombinase disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007127">
        <property type="term" value="P:meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000042">
        <property type="term" value="P:negative regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22877">
        <property type="entry name" value="Srs2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="20"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="337"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="683"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0135820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG61893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1088" mass="123969" checksum="3C9B1913D380F9D8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLM0</accession>
    <name>Q6FLM0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0L02387g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLM0"/>
    <dbReference type="FunCoup" id="Q6FLM0">
        <property type="interactions" value="800"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLM0"/>
    <dbReference type="KEGG" id="cgr:2890904"/>
    <dbReference type="CGD" id="CAL0135572">
        <property type="gene designation" value="CAGL0L02387g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02387g"/>
    <dbReference type="eggNOG" id="KOG4098">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113004_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FLM0"/>
    <dbReference type="OMA" id="CFKMIGG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="69"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0135572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="13000" checksum="D48945EC2C460769" modified="2004-07-19" version="1">MDQKTNAFQIKYNDYKQTLETLQAKIIELGHDKDEHDVVLSTLKNTDENRKCYRMINSALVETDVKTTIPILSTKRANLEEAIEKMKAELIKTAEEFEKWKKDNKIQVVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLR8</accession>
    <name>Q6FLR8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0L01221g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLR8"/>
    <dbReference type="FunCoup" id="Q6FLR8">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890917"/>
    <dbReference type="CGD" id="CAL0135722">
        <property type="gene designation" value="CAGL0L01221g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01221g"/>
    <dbReference type="eggNOG" id="ENOG502R2RI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012632_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLR8"/>
    <dbReference type="OMA" id="NYSKGFT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="720"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="880"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="306"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="915"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="956"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="978"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0135722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="994" mass="111612" checksum="E12A1D3C61BE041A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLX2</accession>
    <name>Q6FLX2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0K12782g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14 15 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLX2"/>
    <dbReference type="FunCoup" id="Q6FLX2">
        <property type="interactions" value="745"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLX2"/>
    <dbReference type="MEROPS" id="C85.006"/>
    <dbReference type="KEGG" id="cgr:2890427"/>
    <dbReference type="CGD" id="CAL0134745">
        <property type="gene designation" value="CAGL0K12782g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12782g"/>
    <dbReference type="eggNOG" id="KOG3288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049327_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLX2"/>
    <dbReference type="OMA" id="TRCILVY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="10">
        <location>
            <begin position="111"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0134745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="310" mass="34832" checksum="27453DD7188E1493" modified="2004-07-19" version="1">MRLKVVGITGADKVITIGNDKLLKDLLEVIEVTGDQCKGIRFGYPPQKVDITEENLGRNLEELGLSTGEKVTLISDMPKDVSSSISGKNNSPPVELKGNQVRVDETNNEILQIHEVPDDNSCLFHSISYTKHQKISLTQILREICAQEILSDKAKYNAAILDQSNEDYARWILQKDAWGGGIEIGILSDYLKIAIYVLDLDTLTIGKFNEEKFDDFVIISFNGVHYDAVELLYRQTNVRKTVFNLISEPELCGNVLEKTIELGKKLRSSGYKFNTRKDKIKCNVCKAEFVGEREVARHAESSGHYDFGQV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM28</accession>
    <name>FEN1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flap endonuclease 1</fullName>
            <shortName evidence="1">FEN-1</shortName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FEN1</name>
        <name type="ordered locus">CAGL0K11506g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="1">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM28"/>
    <dbReference type="SMR" id="Q6FM28"/>
    <dbReference type="FunCoup" id="Q6FM28">
        <property type="interactions" value="1126"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM28"/>
    <dbReference type="EnsemblFungi" id="CAGL0K11506g-T">
        <property type="protein sequence ID" value="CAGL0K11506g-T-p1"/>
        <property type="gene ID" value="CAGL0K11506g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890519"/>
    <dbReference type="CGD" id="CAL0133801">
        <property type="gene designation" value="CAGL0K11506g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K11506g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11506g"/>
    <dbReference type="eggNOG" id="KOG2519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032444_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FM28"/>
    <dbReference type="OMA" id="MGIPWVQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000403569" description="Flap endonuclease 1">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-domain">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="I-domain">
        <location>
            <begin position="120"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with PCNA" evidence="1">
        <location>
            <begin position="338"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <sequence length="381" mass="43067" checksum="CAF93278E808F5C7" modified="2004-07-19" version="1">MGIKGLNSIITEHVPSAIRKSDIKAFFGRKVAIDASMSLYQFLIAVRQQDGGQLSTETGETTSHLMGMFYRTLRMIDNGIKPCYVFDGKPPVLKSHELDKRTSRREETEKKLAEATEEAEKMKHERRLVKVSKEHNDEAKKLLELMGIPYVNAPGEAEAQCAELAKKGKVYAAASEDMDTLCYRTPYLLRHLTFSEARKEPIHEINTEIVLQGLELTIDQFIDLGIMLGCDYCDSIKGVGPVTALKLMKEHGSLEKIVEYIESGEANNKWKVPENWPYKEARELFVKPDVIDANEIDLKWTPPKEDELIQYLCHEKKFSEERVRSGIKRLQKGLKSGVQGRLDGFFKVVPKTKEQLEAAAAKAKLAKKNAKGAKGKVTKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMG1</accession>
    <name>Q6FMG1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RHO4</name>
        <name evidence="12 13" type="ordered locus">CAGL0K08316g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448583.1">
        <property type="nucleotide sequence ID" value="XM_448583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMG1"/>
    <dbReference type="FunCoup" id="Q6FMG1">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMG1"/>
    <dbReference type="GeneID" id="2890351"/>
    <dbReference type="KEGG" id="cgr:2890351"/>
    <dbReference type="CGD" id="CAL0134895">
        <property type="gene designation" value="RHO4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08316g"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_1_1"/>
    <dbReference type="InParanoid" id="Q6FMG1"/>
    <dbReference type="OMA" id="GAFAHIQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090338">
        <property type="term" value="P:positive regulation of formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0134895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="323" mass="35642" checksum="F67625F1306EE09E" modified="2004-07-19" version="1">MMQVDYFSGIGGIPRGGGRSNSRVSSTTLPESLVSGQSDDTLNTYGATSLKLSRSRINPFDRTLSQVESFEHMKRAHKIPDYHLKIVVVGDGAVGKTSLLISYVEKVFKHENIPTIFENYVTNIQGPKGQIIELALWDTAGQEEYSRLRPLSYTGADVLMICYAIDSITSLKNVEDVWFPEVRHFCPGTPVMLVGLKSDLYEEESCDSKVDPAEADSIAKKNGAFAHIQCSAKLRVKVDNVFYAAINELLAEQLISQNHNAPILKSIFKLKKLKLSEPIDIEEQYYDGENGGDDNDGSSSGNVAALPSTIVKKNIRKSKCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMR6</accession>
    <name>Q6FMR6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Early meiotic induction protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EMI1</name>
        <name evidence="1 2" type="ordered locus">CAGL0K05797g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448478.1">
        <property type="nucleotide sequence ID" value="XM_448478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMR6"/>
    <dbReference type="STRING" id="284593.Q6FMR6"/>
    <dbReference type="GeneID" id="2890471"/>
    <dbReference type="KEGG" id="cgr:2890471"/>
    <dbReference type="CGD" id="CAL0134449">
        <property type="gene designation" value="EMI1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05797g"/>
    <dbReference type="eggNOG" id="ENOG502S4MN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114639_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FMR6"/>
    <dbReference type="OMA" id="GQFRNYY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0134449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10498" checksum="6867DF6F172CC737" modified="2004-07-19" version="1">MSQENVKYPTTMSCREAFDQLTTCLSIGGQFRNYYRYGEFSACEKQVNKFKFCILNAKDPVKVQEWYHNQVEENKLRRGSSDIVWKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMS3</accession>
    <name>Q6FMS3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">G1-specific transcriptional repressor WHI5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0K05643g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMS3"/>
    <dbReference type="FunCoup" id="Q6FMS3">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMS3"/>
    <dbReference type="KEGG" id="cgr:2890464"/>
    <dbReference type="CGD" id="CAL0134531">
        <property type="gene designation" value="CAGL0K05643g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05643g"/>
    <dbReference type="eggNOG" id="ENOG502RW1U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_637769_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMS3"/>
    <dbReference type="OMA" id="NEMYSEV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039198">
        <property type="entry name" value="Srl3/Whi5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246:SF1">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0134531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="46557" checksum="7BA1091CF926EC0E" modified="2004-07-19" version="1">MATRSREYTGAEGLGVRVGVEGDSDDESMGRDEDVPRGSRVTVFGEGRVPETPSPPRNSSHARRSSTSLGFLGTPTHPGRYFDVPNSPSSNKGRKTSISHESGSGRTRLLPPTTPKSRQTEVFMSPSPKLRSPQVSKEIEKKPIKEISNELKTRLNYALMKLQNGWVDKSLPELEHTLATDRGDGINEIGQGQNSGEVFSKLDNNDAGKDFLQQRRKSGYVNQFAGDDSSSATFKFEGLKGNTQSNDKGGDERAGTKTAIKTESNEMYSEVQSDSDENSNDEGNSAHSAFLKALSSPKKKQKSSSSTSYPVSPLRWTSTSRPKPLTLDTNLENTKKNTKGPPLEVEAIETLMSLASPKKSSGSLDEALASNDSASGRPGSVTGKGATPIFLRNDVLRQKNASNEGQLRLGNNEILAEKKSDVETEVDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMT0</accession>
    <name>Q6FMT0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0K05489g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMT0"/>
    <dbReference type="FunCoup" id="Q6FMT0">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMT0"/>
    <dbReference type="KEGG" id="cgr:2890488"/>
    <dbReference type="CGD" id="CAL0133939">
        <property type="gene designation" value="CAGL0K05489g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05489g"/>
    <dbReference type="eggNOG" id="KOG3894">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069210_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FMT0"/>
    <dbReference type="OMA" id="RLQFQQY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="249"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0133939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="340" mass="39354" checksum="4F04F9EBD5F7D4FA" modified="2004-07-19" version="1">MSNLTPLFRQYVSIIADESTGLQEAQSETKSSLNEIVTRDSFLKECRSLAKFLFELNTVLKSVCEEYMNDFSMTEAEKDNFDAEARLQLQEYVKKLKHLEQYEKGRRKLIDEQIRKISGSLNFFKYNNRNIDKRDFISYQNFNNDFRSGVLRSLNLWLKYVSSEFSNMQQERLASQRKFQQSLSFSQPSQEVDLNNHSEVDLTESISLTVSQSQPVEHIQDEIKQYEETISQLTQEQLQVLETEHEELINQKNEQLKKVGLINKTIMEIVGVQSELAAHLQVQSQNINSMLDNQDIIETNITKGNKELKKAQRAAGKTAKLTTYIAVIIGILILLLDYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMT4</accession>
    <name>Q6FMT4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K05401g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMT4"/>
    <dbReference type="FunCoup" id="Q6FMT4">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMT4"/>
    <dbReference type="KEGG" id="cgr:2890484"/>
    <dbReference type="CGD" id="CAL0134221">
        <property type="gene designation" value="CAGL0K05401g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05401g"/>
    <dbReference type="eggNOG" id="KOG3355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070631_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FMT4"/>
    <dbReference type="OMA" id="PEYDCST"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060904">
        <property type="term" value="P:regulation of protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="83"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="207" mass="23360" checksum="6125A7A33DE15045" modified="2004-07-19" version="1">MAKRIGRFHGSHIVRAIAALTLVGLVWYFFNTDSSMSVSAPMAGRLRDTVEPVSNVEKSGSGVSQEDKMKAIDDATIMPLMEDKQAKVELGRASWKYFHTLLARFPDKPTKEERQKLKTFLELYAELYPCGECAYHFVKLMDKYPPQTSSRTAAALWGCHVHNIVNEYLKKPEYDCSTILEDYDCGCGDTSVKNNKVTVEKEGRQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN20</accession>
    <name>Q6FN20_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent DNA helicase II subunit Ku80</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">YKU80</name>
        <name evidence="11 12" type="ordered locus">CAGL0K03443g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448374.1">
        <property type="nucleotide sequence ID" value="XM_448374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN20"/>
    <dbReference type="FunCoup" id="Q6FN20">
        <property type="interactions" value="173"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN20"/>
    <dbReference type="GeneID" id="2890175"/>
    <dbReference type="KEGG" id="cgr:2890175"/>
    <dbReference type="CGD" id="CAL0134697">
        <property type="gene designation" value="YKU80"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03443g"/>
    <dbReference type="eggNOG" id="KOG2326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029650_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN20"/>
    <dbReference type="OMA" id="DIRGFMD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097695">
        <property type="term" value="P:establishment of protein-containing complex localization to telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034502">
        <property type="term" value="P:protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Ku" evidence="10">
        <location>
            <begin position="311"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="602"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0134697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="615" mass="69585" checksum="2FF11FF4B9755DAB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN78</accession>
    <name>Q6FN78_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Negative regulator of sporulation PMD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K02101g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN78"/>
    <dbReference type="KEGG" id="cgr:2890335"/>
    <dbReference type="CGD" id="CAL0134623">
        <property type="gene designation" value="CAGL0K02101g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02101g"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_252311_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN78"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1367"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1556"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="979"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1248"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1556"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1570"/>
            <end position="1590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1633" mass="181994" checksum="86EB151EB5830A9F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2025-06-18" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN96</accession>
    <name>GPD1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Glycerol-3-phosphate dehydrogenase [NAD(+)] 1</fullName>
            <ecNumber>1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">GPD1</name>
        <name type="ordered locus">CAGL0K01683g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448298.1">
        <property type="nucleotide sequence ID" value="XM_448298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN96"/>
    <dbReference type="SMR" id="Q6FN96"/>
    <dbReference type="FunCoup" id="Q6FN96">
        <property type="interactions" value="650"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN96"/>
    <dbReference type="EnsemblFungi" id="CAGL0K01683g-T">
        <property type="protein sequence ID" value="CAGL0K01683g-T-p1"/>
        <property type="gene ID" value="CAGL0K01683g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890024"/>
    <dbReference type="KEGG" id="cgr:2890024"/>
    <dbReference type="CGD" id="CAL0133949">
        <property type="gene designation" value="GPD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01683g"/>
    <dbReference type="eggNOG" id="KOG2711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_2_4_1"/>
    <dbReference type="InParanoid" id="Q6FN96"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000294">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000138086" description="Glycerol-3-phosphate dehydrogenase [NAD(+)] 1">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
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            <name>substrate</name>
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            <name>NAD(+)</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="400" mass="43988" checksum="DE850B128571D8E5" modified="2004-07-19" version="1">MSNSAAGRLNQTSHILNESIKNDDISLRRSQPSTTSLQALEHPFKVTVIGSGNWGTTIAKVVAENTALNPHLFVSRVDMWVFEEKIDGKNLTEIINEQHENVKYLPDIKLPENLVANPNLIDSVKGADILIFNIPHQFLPRIVSNLKNHVGPHVRAISCLKGFEVGKKGVQLLSSYVTDELGIQCGALSGANLAPEVAKEHWSETTVAYHIPKDFRGEGKDVDHKLLKALFHRPYFHVNVIEDVAGISIAGALKNVVALGCGFVEGLGWGNNAAAAIQRVGLGEIIKFGQMFFPESRVQTYYQESAGVADLITTCSGGRNVRVAKHMAKTGKSALDAEKELLNGQSAQGIITCKEVHEWLETCEMTHEFPLFEAVYQIVYNNVPMKNLPDMIEELECIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNA4</accession>
    <name>Q6FNA4_CANGA</name>
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        <recommendedName>
            <fullName evidence="12">G protein-coupled receptor GPR1</fullName>
        </recommendedName>
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        <name evidence="9 10" type="ordered locus">CAGL0K01507g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
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                <person name="Thierry A."/>
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                <person name="Scarpelli C."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNF8</accession>
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        <recommendedName>
            <fullName evidence="11">Protein DOA1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8 9" type="ordered locus">CAGL0K00275g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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        <name type="synonym">Nakaseomyces glabratus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
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            <taxon>Saccharomycetes</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
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                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
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        <property type="term" value="P:G1 to G0 transition"/>
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    </dbReference>
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        <property type="term" value="P:mitochondria-associated ubiquitin-dependent protein catabolic process"/>
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    </dbReference>
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        <property type="term" value="P:ribophagy"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
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        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="98"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="216"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="6">
        <location>
            <begin position="350"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="7">
        <location>
            <begin position="463"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="80513" checksum="0386EB1520DCB5CD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNG4</accession>
    <name>Q6FNG4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">V-type proton ATPase subunit d</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Vacuolar proton pump subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0J11880g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNG4"/>
    <dbReference type="FunCoup" id="Q6FNG4">
        <property type="interactions" value="962"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNG4"/>
    <dbReference type="KEGG" id="cgr:2889433"/>
    <dbReference type="CGD" id="CAL0132986">
        <property type="gene designation" value="CAGL0J11880g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11880g"/>
    <dbReference type="eggNOG" id="KOG1647">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FNG4"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3240:FF:000002">
        <property type="entry name" value="Vacuolar atp synthase subunit d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00271">
        <property type="entry name" value="ATP_synth_D_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0132986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG61181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="262" mass="29935" checksum="8EF69DB3BB20DD53" modified="2004-07-19" version="1">MSGNREQVFPTRMTLGLMKTKLKGANQGHSLLKRKSEALTKRFRDITKRIDEAKQKMGRVMQTAAFSLAEVSYATGENIGYQVQESVLNARFKVKARQENVSGVYLPQFESYVDSDINDFKLTGLGRGGQQVQRAKDIYSKAVETLVELASLQTAFIILDEVIKVTNRRVNAIEHVIIPRTENTIAYINSELDELDREEFYRLKKVQEKKQRETALLDAEMKLKRDKLREEGISNKQNLMEAAVDDNEVNALVNEQEDDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNI5</accession>
    <name>Q6FNI5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0J11418g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNI5"/>
    <dbReference type="FunCoup" id="Q6FNI5">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNI5"/>
    <dbReference type="KEGG" id="cgr:2889525"/>
    <dbReference type="CGD" id="CAL0133036">
        <property type="gene designation" value="CAGL0J11418g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11418g"/>
    <dbReference type="HOGENOM" id="CLU_801666_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNI5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="346" mass="39742" checksum="42C3276776831052" modified="2004-07-19" version="1">MKENGRKSRSNALRATLNPNSQNNNISDLDLYKKHKAEYGTRLMTEDLTSPEEIMLLNEGSPTTLRSKGKSFTENDEKDSMRKVVINNLEEDNLDPPKLKKELQFIGKKKASPQYQVLENKERSLDPIERHRRKTSLLKAIGEPVPLPYLQNGPNNYVNVKNEESQRFDQTEMDSIDQRWNSVIESNRKIVKARLNEIRNAGKGIRLDSPQPRRVSEENVQGHSHNILEQSEKSNVSLKSEGHQDMYASFDDGYGDSIVIGTPKQDLIKSKRLDDAKVLSDIKSILLENSTKLDTVIEVLGSSKKVKLDKNNKIALNRLYYSKNNLYWILCIIILLICNIYVYYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNQ5</accession>
    <name>Q6FNQ5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor tau 95 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0J09878g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNQ5"/>
    <dbReference type="FunCoup" id="Q6FNQ5">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNQ5"/>
    <dbReference type="KEGG" id="cgr:2889424"/>
    <dbReference type="CGD" id="CAL0133408">
        <property type="gene designation" value="CAGL0J09878g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09878g"/>
    <dbReference type="eggNOG" id="KOG2473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020038_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNQ5"/>
    <dbReference type="OMA" id="PWRNTYI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="231"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="524"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0133408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="72706" checksum="3CA5930345E3CE7A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-12-07" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNV1</accession>
    <name>NOP14_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Probable nucleolar complex protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NOP14</name>
        <name type="ordered locus">CAGL0J08844g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448093.1">
        <property type="nucleotide sequence ID" value="XM_448093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNV1"/>
    <dbReference type="SMR" id="Q6FNV1"/>
    <dbReference type="FunCoup" id="Q6FNV1">
        <property type="interactions" value="1230"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNV1"/>
    <dbReference type="EnsemblFungi" id="CAGL0J08844g-T">
        <property type="protein sequence ID" value="CAGL0J08844g-T-p1"/>
        <property type="gene ID" value="CAGL0J08844g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889679"/>
    <dbReference type="KEGG" id="cgr:2889679"/>
    <dbReference type="CGD" id="CAL0133322">
        <property type="gene designation" value="CAGL0J08844g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J08844g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08844g"/>
    <dbReference type="eggNOG" id="KOG2147">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008874_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNV1"/>
    <dbReference type="OMA" id="KSCWPSL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000137158" description="Probable nucleolar complex protein 14">
        <location>
            <begin position="1"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="777"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="799" mass="92531" checksum="F5165E4A06F1204E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNV2</accession>
    <name>Q6FNV2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0J08822g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNV2"/>
    <dbReference type="FunCoup" id="Q6FNV2">
        <property type="interactions" value="1964"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNV2"/>
    <dbReference type="KEGG" id="cgr:2889678"/>
    <dbReference type="CGD" id="CAL0133554">
        <property type="gene designation" value="CAGL0J08822g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08822g"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_12_1_1"/>
    <dbReference type="InParanoid" id="Q6FNV2"/>
    <dbReference type="OMA" id="YDVTMVA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010696">
        <property type="term" value="P:positive regulation of mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="221"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="314"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="318"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0133554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="443" mass="52057" checksum="D70A01500F08CAC0" modified="2004-07-19" version="1">MNNTEDMFRDVENASQNMASTVNTSRMDQRQRRALTDLTSQKVNRIHTSKTIKDIPAYLSNYTADGENKNIDQAFNHSNDQDIGLVNQINSGYANVENEPGKETDHIFIDQDDLSDLDIVQEDSLREQLEEFEHDFENFVEPLSPIFNDEIQDTLDRAFKEYYRATPDMEDDDTFDAVMVTEYGSDIFRYMRKLELKYRPNPYYMAGQPELKWEYRKTVIDWIVQVHERFQLLPETLYLTINIIDRFLSRKNITLNRFQLVSATALLIASKYEEINCPTIKDIVYMVDNTYSRDDIIEAEKYMIDALDFEVSWPGPMSFLRRISKADDYEYRTRNLAKYLLETTLMESSLISALPSWLAAGAYFLSRIILGYEEWTLKHVYYSGYTHEQLYPLATLILDNCQNYEESHQAIWTKYSQPQYHQVSILVTKFLGRVSSDDMSEIY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPK7</accession>
    <name>ACEA_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate lyase</fullName>
            <shortName evidence="5">ICL</shortName>
            <shortName evidence="5">Isocitrase</shortName>
            <shortName evidence="5">Isocitratase</shortName>
            <ecNumber evidence="1">4.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Methylisocitrate lyase</fullName>
            <shortName evidence="5">MICA</shortName>
            <ecNumber evidence="1">4.1.3.30</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Threo-D(S)-isocitrate glyoxylate-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ICL1</name>
        <name type="ordered locus">CAGL0J03058g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Also acts on 2-methylisocitrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Glyoxysome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_447837.2"/>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPK7"/>
    <dbReference type="EnsemblFungi" id="CAGL0J03058g-T">
        <property type="protein sequence ID" value="CAGL0J03058g-T-p1"/>
        <property type="gene ID" value="CAGL0J03058g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889724"/>
    <dbReference type="KEGG" id="cgr:2889724"/>
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        <property type="gene designation" value="ICL1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J03058g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03058g"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="reaction ID" value="UER00719"/>
    </dbReference>
    <dbReference type="PHI-base" id="PHI:8917"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0329">Glyoxylate bypass</keyword>
    <keyword id="KW-0330">Glyoxysome</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0576">Peroxisome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="chain" id="PRO_0000068785" description="Isocitrate lyase">
        <location>
            <begin position="1"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Microbody targeting signal" evidence="4">
        <location>
            <begin position="551"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="217"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="436"/>
            <end position="440"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P28240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P28299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P9WKK7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="553" mass="62177" checksum="D97EB314A3306D9C" modified="2009-02-10" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ01</accession>
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        <recommendedName>
            <fullName evidence="5">Protein CAF130</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2 3" type="ordered locus">CAGL0I10428g</name>
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    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        </lineage>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Westhof E."/>
                <person name="Wirth B."/>
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                <person name="Zivanovic I."/>
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                <person name="Thierry A."/>
                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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    </reference>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129971"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG60638.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase EFM2</fullName>
        </recommendedName>
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            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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    <dbReference type="HOGENOM" id="CLU_049351_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ37"/>
    <dbReference type="OMA" id="DDFGEMK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="46932" checksum="657DD2936483252C" modified="2004-07-19" version="1">MFDPLDLYTAEPPTVDDSLVITDHSVAGTDCDKQFANDVEEDEDYIVDILDLPPCSLAPPQVILIVLILLRPREQLNFANNDDNKEDIPLELDNNDEPMLNDLVQWYTINWPHEKLNTKDKLLRNIPRTTSIVSHESLLKFYTSVLQYYSKAEATKDSNEYVKRILKEVSLRIAENCGRTAQPAIQRKFRIKNLDKTIMLHEPSLTADNLGWKTWGSSLILGEIVVSYLENLSSTFESNRKVRTLELGAGTGLVGIAWAAKWRDKFCNSKTEIYLTDLPEIVDNLKDNVKINNLQDIATADVLDWTNPDTFTEKYGNERFDYIVIADPIYSPQHPEWVVNMIVKFLEVNGICHLEIPLRERYSKERDYLWRLLEEHNLDVVHEIYSSGKDDWGKVDYVYKMLKFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ51</accession>
    <name>Q6FQ51_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SPS-sensor component PTR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I09130g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ51"/>
    <dbReference type="FunCoup" id="Q6FQ51">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ51"/>
    <dbReference type="KEGG" id="cgr:2888966"/>
    <dbReference type="CGD" id="CAL0132164">
        <property type="gene designation" value="CAGL0I09130g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09130g"/>
    <dbReference type="eggNOG" id="ENOG502QUFR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028479_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ51"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043200">
        <property type="term" value="P:response to amino acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="81405" checksum="6FF2A8804AF7A6FE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQK4</accession>
    <name>Q6FQK4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0I05544g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQK4"/>
    <dbReference type="SMR" id="Q6FQK4"/>
    <dbReference type="FunCoup" id="Q6FQK4">
        <property type="interactions" value="883"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQK4"/>
    <dbReference type="KEGG" id="cgr:2889271"/>
    <dbReference type="CGD" id="CAL0132384">
        <property type="gene designation" value="CAGL0I05544g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05544g"/>
    <dbReference type="eggNOG" id="KOG1433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041732_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FQK4"/>
    <dbReference type="OMA" id="RAYNSNH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905334">
        <property type="term" value="F:Swi5-Sfr1 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030491">
        <property type="term" value="P:heteroduplex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007533">
        <property type="term" value="P:mating type switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000708">
        <property type="term" value="P:meiotic strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036298">
        <property type="term" value="P:recombinational interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120290">
        <property type="term" value="P:stalled replication fork localization to nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="139"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="317"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0132384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="383" mass="41857" checksum="BAF0DE3496EFB788" modified="2004-07-19" version="1">MTEVHEDHGVPDSQVNVSPISTAPAETTQSSTNRSMDYNSGEQLFHQEQYEEGMEEDAALASFVPLEKLQVNGITSTDIKKLRESGLHTVEAVAYAPKKDLLEIKGISETKADRLLNEAARLVPMGFVTAADFHMRRSEMICLTTGSKNLDTLLGGGIETGSITELFGEFRTGKSQLCHSLAVTCQIPLDLGGGEGKCLYIDTEGTFRPVRLVSIAQRFGLDPDDALNNVAYARAYNADHQMRLLDAAAQMMSESRFSLIVVDSVMALYRTDFSGRGELSARQMHLAKFMRALQRLADQFGVAVVVTNQVVAQVDGGMSFNPDPKKPIGGNIMAHSSTTRLGFKKGKGCQRYCKVVDSPCLPEAECVFAIYEDGIGDPREEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQN7</accession>
    <name>Q6FQN7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I04774g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQN7"/>
    <dbReference type="FunCoup" id="Q6FQN7">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889364"/>
    <dbReference type="CGD" id="CAL0129668">
        <property type="gene designation" value="CAGL0I04774g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04774g"/>
    <dbReference type="eggNOG" id="ENOG502QY2R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_671228_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQN7"/>
    <dbReference type="OMA" id="WICEPTQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015278">
        <property type="term" value="F:intracellularly gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006688">
        <property type="term" value="P:glycosphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903514">
        <property type="term" value="P:release of sequestered calcium ion into cytosol by endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031581">
        <property type="entry name" value="Csg2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16965">
        <property type="entry name" value="CSG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47336" checksum="35E2C4238E87E26E" modified="2004-07-19" version="1">MSNSLLWFTGVIGYVIQTKCISTIQSRQVVATSASEQDAAGVDTGNTSSGTYILTLYLTFIYFASWTFLMPIAKMWKEFKQSTEPDQADLVPIVEGDEDPEHRNTNRMLLQYYQRQANKNNQIVSWRNFTYFLKLIVLTALLIIALVTYNLALSMSPAFDVALIQNTSIFEIVTLLYGVCGLARRQNVFRNFIIMLTALIGILIISYTKATCDMLSGKLSINKDTGELSDPFLFDRLKSSLLCGLGALTIGPFAVLWNRWFGGRSRSSSVLTKTLPQSSVSHSLLEHIKARNAVNSFVKQCTHLSFIGLVGMIVLFPFLPAIPTSSETVSFLYSDRTFWLSAMVGIVFGVIPCLLSLLLLNRNASPEYLTTCNLGAIIFMGISDWISEPTQTTIIRWEVIGYIILTICCLILSFTFNEKKMQH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQQ6</accession>
    <name>IF4A_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Eukaryotic initiation factor 4A</fullName>
            <shortName>eIF-4A</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TIF1</name>
        <name type="synonym">TIF41</name>
        <name type="ordered locus">CAGL0I04356g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQQ6"/>
    <dbReference type="SMR" id="Q6FQQ6"/>
    <dbReference type="FunCoup" id="Q6FQQ6">
        <property type="interactions" value="1420"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQQ6"/>
    <dbReference type="EnsemblFungi" id="CAGL0I04356g-T">
        <property type="protein sequence ID" value="CAGL0I04356g-T-p1"/>
        <property type="gene ID" value="CAGL0I04356g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889047"/>
    <dbReference type="CGD" id="CAL0130157">
        <property type="gene designation" value="TIF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I04356g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04356g"/>
    <dbReference type="eggNOG" id="KOG0327">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQQ6"/>
    <dbReference type="OMA" id="FGCQALV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000232133" description="ATP-dependent RNA helicase eIF4A">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="234"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="171"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="396" mass="44787" checksum="917BD19CF38B2167" modified="2004-07-19" version="1">MSTDQMTQLDESQIETNYDKVVYEFDDMNLNEKLLRGVFGYGFNKPSAIQQRAIMPIIEGNDVLAQAQSGTGKTGTFSIAALQRIDPAIKAPQALMLAPTRELALQIQKVVMALGFHMDIKVHACIGGTSFVEDAEGLRDAQIVVGTPGRVFDNIQRRKFKVDNIKMFILDEADEMLSTGFKEQIYQIFTMLPPTTQVVLLSATMPRDVLEVTAKFMQNPVRILVKKDELTLEGIKQFYVNVEEEQFKYDCLTDLYDSISVTQAVIFCNTRRKVEELTQRLTADNFTVSSIYSDLPQQERDTIMKEFRSGSSRILISTDLLARGIDVQQVSLVINYDLPTNKENYIHRIGRGGRFGRKGVAINFIVNEDVQALRELEQFYSTQIEELPSDIGTLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQR0</accession>
    <name>Q6FQR0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I04268g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQR0"/>
    <dbReference type="FunCoup" id="Q6FQR0">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQR0"/>
    <dbReference type="KEGG" id="cgr:2889076"/>
    <dbReference type="CGD" id="CAL0132592">
        <property type="gene designation" value="CAGL0I04268g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04268g"/>
    <dbReference type="eggNOG" id="KOG3114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061845_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQR0"/>
    <dbReference type="OMA" id="CITITIG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38252" checksum="03A64DCEDCBEC4FA" modified="2004-07-19" version="1">MMSDSDRLFDIDDGMDGVDDFISEPNPFEEHANTSHNKYGSGTGDNIMGDESGKTVNDLPPAYDNTIALEPQRVAPDRDGSIPQGKLPPGLLNYYSRYFQLSNEGLKKRIMYPRSFYQDSRDPEEQNFEIDDEDEDEASVLSDLYGPVWITATAVMAKFVVVTLVEIVKDGLVLGVPRQAAEDGSYLPSTFWEKQFVNLIHSIWLYYAHTFISPLLIYRGFQNHYDGMKMKSRYELISIYGYSNLIWVSISVILGVLEGFSQPVARSTKWLEFIIFGLGLIPVFFYILRESMYRIQNKVVPTSELFKEIYKVPFVVVLFLLIVFWLIYGILILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQY3</accession>
    <name>Q6FQY3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0I02508g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQY3"/>
    <dbReference type="FunCoup" id="Q6FQY3">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQY3"/>
    <dbReference type="KEGG" id="cgr:2889385"/>
    <dbReference type="CGD" id="CAL0132152">
        <property type="gene designation" value="CAGL0I02508g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02508g"/>
    <dbReference type="eggNOG" id="KOG3386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079690_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FQY3"/>
    <dbReference type="OMA" id="AKTVACH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0132152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="175" mass="19799" checksum="9C873568ACBEBE06" modified="2004-07-19" version="1">MKMDHSGMNRMGMDHSGMDHSGMNHPGMNHGGDDDMCAMSMVFTWNYKNTCVVFNWWKIKTLHGLLLSCIAIALITGFYEYLKFYLYRKNRDSEAVVTSTSATNGSLNSPSPLTKRYAVSRSLWYGVQVGYSFLLMLVFMTYNGWLMLAVVVGAIWGHYHWGIRCTPEAGTLACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR07</accession>
    <name>Q6FR07_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein SIP3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0I01980g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR07"/>
    <dbReference type="KEGG" id="cgr:2888950"/>
    <dbReference type="CGD" id="CAL0129478">
        <property type="gene designation" value="CAGL0I01980g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01980g"/>
    <dbReference type="eggNOG" id="ENOG502QU87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001720_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR07"/>
    <dbReference type="OMA" id="WSIAIAY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1139"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="371"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="9">
        <location>
            <begin position="841"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0129478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1304" mass="149379" checksum="79A5470AB212EB52" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR89</accession>
    <name>Q6FR89_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0H10516g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR89"/>
    <dbReference type="FunCoup" id="Q6FR89">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR89"/>
    <dbReference type="KEGG" id="cgr:2888478"/>
    <dbReference type="CGD" id="CAL0131976">
        <property type="gene designation" value="CAGL0H10516g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10516g"/>
    <dbReference type="eggNOG" id="KOG4575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008674_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FR89"/>
    <dbReference type="OMA" id="CTPYELT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044697">
        <property type="term" value="C:HICS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990344">
        <property type="term" value="P:secondary cell septum biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052557">
        <property type="entry name" value="CAP/Cytokinesis_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056409">
        <property type="entry name" value="Ig_CYK3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46333:SF2">
        <property type="entry name" value="CYTOKINESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24584">
        <property type="entry name" value="Ig_CYK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="880" mass="100194" checksum="528D2ECA034F4E68" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRD3</accession>
    <name>Q6FRD3_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H09482g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447211.1">
        <property type="nucleotide sequence ID" value="XM_447211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRD3"/>
    <dbReference type="KEGG" id="cgr:2888614"/>
    <dbReference type="CGD" id="CAL0131708">
        <property type="gene designation" value="CAGL0H09482g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09482g"/>
    <dbReference type="HOGENOM" id="CLU_1895923_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRD3"/>
    <dbReference type="OMA" id="CMAGANK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274157" evidence="1">
        <location>
            <begin position="19"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="134" mass="15339" checksum="D745CB36FD40E3AC" modified="2004-07-19" version="1">MKLTNLLSLVVPISVAMCIDSNNKEELHGYVQGYINELVEKHQGAVLASIQAATDPENEQTIEFHNLQQGIDLDKNKEWTIGESHLKQVDDNILGVMIQKLYSMAKTNLWKRFNLKETGLYYYSFTSTNIFEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRF7</accession>
    <name>Q6FRF7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0H08932g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRF7"/>
    <dbReference type="FunCoup" id="Q6FRF7">
        <property type="interactions" value="1428"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRF7"/>
    <dbReference type="KEGG" id="cgr:2888846"/>
    <dbReference type="CGD" id="CAL0130268">
        <property type="gene designation" value="CAGL0H08932g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08932g"/>
    <dbReference type="eggNOG" id="KOG0276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005507_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FRF7"/>
    <dbReference type="OMA" id="YVDYYPQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="326"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="607"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="807"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="841"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="851"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="891"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0130268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG60120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="902" mass="102241" checksum="3F3BB30AE9BEA156" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRN7</accession>
    <name>Q6FRN7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Central kinetochore subunit MCM21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0H07139g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-O/MCM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRN7"/>
    <dbReference type="FunCoup" id="Q6FRN7">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRN7"/>
    <dbReference type="KEGG" id="cgr:2888557"/>
    <dbReference type="CGD" id="CAL0129956">
        <property type="gene designation" value="CAGL0H07139g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07139g"/>
    <dbReference type="eggNOG" id="ENOG502RXWX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068734_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRN7"/>
    <dbReference type="OMA" id="NHSFATI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000817">
        <property type="term" value="C:COMA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905262">
        <property type="term" value="P:negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071459">
        <property type="term" value="P:protein localization to chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018464">
        <property type="entry name" value="CENP-O"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09496">
        <property type="entry name" value="CENP-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="41464" checksum="C73867B503FB81BC" modified="2004-07-19" version="1">MDTVTVEELLQDVEALTSEINGLQEKSKKLREQLKHPEQFIKFDKAFGDFNDIFEKNPGLRDLLLGYEIDKSATDVDDTNIIPVTPQKKSRSSVVNEKLHSLPEHEWVLKTQPLVEHRLFDESVRDVIDTDILISPSKRKQKIQQLNPNSTGKVSKEPIQYENIYRLFGISYFPLVDPSDLIFDSKTEKMIVTRDMLGIRFDIFNESSKSFEKPHYILLKKSAKSDDWKLFKYTVPNYIDVEGIFAEVTGGLIRTYDDVYLFAKCIYLLLVEIVIRSELFLQLEKDGIIDDLDMDLQSLVIKCTLQGTTKIEFHIHQYSIIACTIKSKIMSDDEKERLAMMLQGSLHDLKYKLISLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRT7</accession>
    <name>Q6FRT7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H05995g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447057.1">
        <property type="nucleotide sequence ID" value="XM_447057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRT7"/>
    <dbReference type="FunCoup" id="Q6FRT7">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRT7"/>
    <dbReference type="ESTHER" id="canga-q6frt7">
        <property type="family name" value="Dienelactone_hydrolase"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888563"/>
    <dbReference type="CGD" id="CAL0131634">
        <property type="gene designation" value="CAGL0H05995g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05995g"/>
    <dbReference type="eggNOG" id="KOG3043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FRT7"/>
    <dbReference type="OMA" id="CERVGAI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="247" mass="27128" checksum="004889079A81816C" modified="2004-07-19" version="1">MASKMLGQCCFKGFYRKGETKGLHKDIFGVDSYVVGLENPSDKVVVIMTDVYGNRLNNVLLTADQIAESGYQVYVPDILFNNPALDLNVPLDIPAWMASHPVDRAHNLVTKYLSDLRKHVNPKFVGIIGYCYGAKFAIKQIDSASGIVDACAIAHPSLVTIEDVAAIGKPLLISAAEEDAIFPEEMRHMTEAKLKEIGARYEIDLFSGVEHGFASRGDVSNPVVKFAMNKALADQLYWFDHFASGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS37</accession>
    <name>Q6FS37_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0H03751g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446957.1">
        <property type="nucleotide sequence ID" value="XM_446957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS37"/>
    <dbReference type="FunCoup" id="Q6FS37">
        <property type="interactions" value="767"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS37"/>
    <dbReference type="KEGG" id="cgr:2888903"/>
    <dbReference type="CGD" id="CAL0130030">
        <property type="gene designation" value="CAGL0H03751g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03751g"/>
    <dbReference type="eggNOG" id="KOG3712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_295949_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS37"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="3">
        <location>
            <begin position="369"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="477"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0130030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113941" checksum="6AA81CB38CE32454" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS80</accession>
    <name>Q6FS80_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MAS1</name>
        <name evidence="17 18" type="ordered locus">CAGL0H02739g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446914.1">
        <property type="nucleotide sequence ID" value="XM_446914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS80"/>
    <dbReference type="FunCoup" id="Q6FS80">
        <property type="interactions" value="944"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS80"/>
    <dbReference type="MEROPS" id="M16.003"/>
    <dbReference type="GeneID" id="2888599"/>
    <dbReference type="KEGG" id="cgr:2888599"/>
    <dbReference type="CGD" id="CAL0131578">
        <property type="gene designation" value="MAS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02739g"/>
    <dbReference type="eggNOG" id="KOG0960">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FS80"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017087">
        <property type="term" value="C:mitochondrial processing peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="15">
        <location>
            <begin position="39"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="16">
        <location>
            <begin position="191"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0131578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG59847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="465" mass="51621" checksum="CDBC66656A0534C5" modified="2004-07-19" version="1">MFRQAVKGIRTLRNFSHCRPRLNALPQTRTSVLPNGLTVASEFIPNKSTATVGIFVDAGSRAENERNNGTAHFLEHLAFKGTQNRSQTDIELEIENIGSHLNAYTSRENTVYYAKSLEGDVPKAVNILSDILTRSVLDPKAIERERDVIIRESEEVDKMYDEVVFDHLHEIAYKQQPLGRTILGPIKNIKSISRKDLKSYITENYKGDRMVLAAAGAVDHEKLVDYAQKYLGHIPKSESPMPLGSPRGPLPVFQRGERLIPENTLPTTHIALALEGVSWSAPDYFIALATQAIVGNWDRAVGTGTNAPSPLAVAVNKGNNTLANSYMSFSTSYADSGLWGMYIVTDSNEHNVQAIIDEVLKEWRRIKAGNITDDEVNRSKAQLKAALLLSLDDTTAILEDIGRQIVTTGKRLSPEEVFEKVDNITKEDIVLWANYRLKNKPVAIVALGNTKTVPSVDYIEKQLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS82</accession>
    <name>Q6FS82_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0H02695g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase. Capable of transferring glucosyl residues to unbound acceptors such as free oligoglucans or oligoglucan derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="12"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS82"/>
    <dbReference type="FunCoup" id="Q6FS82">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS82"/>
    <dbReference type="KEGG" id="cgr:2888809"/>
    <dbReference type="CGD" id="CAL0129886">
        <property type="gene designation" value="CAGL0H02695g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02695g"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017171_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FS82"/>
    <dbReference type="OMA" id="NFKFDWE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000148">
        <property type="entry name" value="Glg2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="379"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="399"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="489"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0129886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG59845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="549" mass="64344" checksum="9E974A33EC57DBAC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSE1</accession>
    <name>Q6FSE1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0H01265g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSE1"/>
    <dbReference type="FunCoup" id="Q6FSE1">
        <property type="interactions" value="827"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSE1"/>
    <dbReference type="KEGG" id="cgr:2888550"/>
    <dbReference type="CGD" id="CAL0132022">
        <property type="gene designation" value="CAGL0H01265g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01265g"/>
    <dbReference type="eggNOG" id="KOG0781">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_8_1_1"/>
    <dbReference type="InParanoid" id="Q6FSE1"/>
    <dbReference type="OMA" id="MVNMVYA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015284">
        <property type="entry name" value="SRX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09201">
        <property type="entry name" value="SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="578"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="167"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0132022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="605" mass="66960" checksum="E02C9DFA6C082744" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSH5</accession>
    <name>CAF17_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CAF17</name>
        <name type="ordered locus">CAGL0H00484g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvT family. CAF17/IBA57 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSH5"/>
    <dbReference type="FunCoup" id="Q6FSH5">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSH5"/>
    <dbReference type="EnsemblFungi" id="CAGL0H00484g-T">
        <property type="protein sequence ID" value="CAGL0H00484g-T-p1"/>
        <property type="gene ID" value="CAGL0H00484g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888811"/>
    <dbReference type="CGD" id="CAL0131432">
        <property type="gene designation" value="CAGL0H00484g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00484g"/>
    <dbReference type="eggNOG" id="KOG2929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_7_3_1"/>
    <dbReference type="InParanoid" id="Q6FSH5"/>
    <dbReference type="OMA" id="PFECNLD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000301695" description="Iron-sulfur cluster assembly factor IBA57 homolog, mitochondrial">
        <location>
            <begin position="37"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P47158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="497" mass="56642" checksum="EBBB7644D15B6DC8" modified="2004-07-19" version="1" precursor="true">MMKTLTRSILDLTRSSKNAVSIQCGRRFISSIKATNLDNALLVYGEIPNKSYLQVRGPDTIGFLNGLVTSKLLPTFVKKNLTTIEVSDEKNKKDTNNNESPEFNEKKGNWGIYNAESHNGPYLSRFGIYSAFLNGKGKLVTDSIIYPSPGVVNDQTEAKIKLYPEYLLEFDKDIIPRMLTSFESHKLHNKIKFEEVKNTKTWDFFISFPGLTQNDPNPWIDNVYVPLTYLKNAEASNEFAESFITSLFPKISNKILGFYIERRTETLLNNDGTAPQFFRIVTTEDVDNAFDAFNSEAFPFTFEKLEKDSSFFKQCKLQYGFLDGSDAIQPDSLMPLELNFDYFPNTVSNNKGCYVGQELTARTYSTGILRKRLIPIEFENLSEQAVKLLNECDKYPDIEVEVDPKNQEPEPLQSTAPSPFGNSPFGNASTKLRQRKKAAGTLISFDGKYGIALFRIEHFKNIYDTPTPSKFFLTIGQEKIDVTPQRPIWYNEWKSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSR6</accession>
    <name>Q6FSR6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA end formation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G08382g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSR6"/>
    <dbReference type="FunCoup" id="Q6FSR6">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSR6"/>
    <dbReference type="KEGG" id="cgr:2888118"/>
    <dbReference type="CGD" id="CAL0130043">
        <property type="gene designation" value="CAGL0G08382g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08382g"/>
    <dbReference type="eggNOG" id="ENOG502QR0S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025953_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSR6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903501">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901901">
        <property type="term" value="P:regulation of protein localization to cell division site involved in cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030846">
        <property type="term" value="P:termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="51638" checksum="18645B228694A5A5" modified="2004-07-19" version="1">MSMETATQVNVDHALPISKIEQIKADLRDYYGVKELSEEQSESINQHINILDAALMQFMSDNHTLEKKHADTQDVNLNLYHGLKRMYNDLLHELGRVKEEKTNTETTDRNNPLEYMADELPYQQTAQRKAYIDSLIMKDDYDEQLKREGTKFLDVMAQLSVLDSSIEENTKSYGMLVRKLGFTLQDLDERIRNGSKALETDDKIDKPIDENNEDDSKAESKEDAKKKISFSKYLKKDETTKRSRNDELNEESEQNKKLKVDDDNGYDNNENINNGLRPILKKRENNKSKSKSSGIKFQTESALVTIYGDGLPQDGLTVSPEELKKILKPFKPGQPREFPLVDNLPNVIKVPKLDLRFDENVNSSDISELKGGPVPCGTRTPLTCRINFNRYSADLEKPAREPVNLDDGDSSKPIIARAFGQNKLLLRKDRGGLPYRRVPDVVRNNYPIRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT15</accession>
    <name>Q6FT15_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0G06138g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT15"/>
    <dbReference type="FunCoup" id="Q6FT15">
        <property type="interactions" value="736"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT15"/>
    <dbReference type="KEGG" id="cgr:2888387"/>
    <dbReference type="CGD" id="CAL0129379">
        <property type="gene designation" value="CAGL0G06138g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06138g"/>
    <dbReference type="eggNOG" id="KOG1165">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019279_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FT15"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001123">
        <property type="entry name" value="CK1/CK1/CK1-D protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="61"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="360"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="501"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0129379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="539" mass="61538" checksum="2E9842C94809A27A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT21</accession>
    <name>Q6FT21_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G06006g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446623.1">
        <property type="nucleotide sequence ID" value="XM_446623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT21"/>
    <dbReference type="FunCoup" id="Q6FT21">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="MEROPS" id="I09.003"/>
    <dbReference type="KEGG" id="cgr:2888329"/>
    <dbReference type="CGD" id="CAL0130817">
        <property type="gene designation" value="CAGL0G06006g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06006g"/>
    <dbReference type="eggNOG" id="ENOG502S7VS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156026_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FT21"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274177" evidence="1">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="110" mass="12391" checksum="7DDB49BDD33EF46C" modified="2004-07-19" version="1">MKLIQYLIIGVTLLVCLVAPVMCHAGSYILSFDESSRALPQNVWEKALGFADELGVKITHEYSLIKGFTLDVPEEVLPKLKKKLADLERDYGVKGHLEEDNLVHAFQEHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTQ3</accession>
    <name>Q6FTQ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleoporin NUP60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G00660g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTQ3"/>
    <dbReference type="FunCoup" id="Q6FTQ3">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTQ3"/>
    <dbReference type="DNASU" id="2888018"/>
    <dbReference type="KEGG" id="cgr:2888018"/>
    <dbReference type="CGD" id="CAL0130636">
        <property type="gene designation" value="CAGL0G00660g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00660g"/>
    <dbReference type="eggNOG" id="ENOG502RZ4Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037434_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTQ3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031990">
        <property type="term" value="P:mRNA export from nucleus in response to heat stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034432">
        <property type="entry name" value="Nup60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28284">
        <property type="entry name" value="NUCLEOPORIN NUP60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28284:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="56461" checksum="2CDE3A00180E5FF5" modified="2004-07-19" version="1">MVSHYDRMKRSSIAPYRRSNDSSNRIDKKTGKKGHGLMSKLKDLVSFGWAQEHHKDNDFSARDTGRERTNVSKGSYAAVPGGFFSSDQSSFILRERSRIMNESTMHSEADTSNAKLADFFAKKGNEPLSEIEMEGVLALMQKSRGVADESSFLGNSSRLLGDISNANASQVLRTGNISTSSALNVPNFKPSTDESRNINAKEVENSTIVSTPLKRKNFDYSSIRSPYRTVIYRFDDSNKKKISSVFDKPESSSQEVDETPKPSNSKPLSNTASALVSLLSDKDAAKESIKPMANPYTSHLTALRKSREDLPSINDKITVPKRRQRSETEDKEEAKITSSNGEAQEDTNIPEGIASRKNEEAQDSFTKYKPMRSSSLRDSVSLAHTESNNEKQMNSPKFVPAPLDKNETKETAKSDLTLTSSDKQSESKPSFSFPVNSTTKSTFMGTKKESTSPAVNSQAVKNVSNNETKEIKPQVHECIYDFGNPTSSGFKKTDIDDTLVSKYRGQFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTT2</accession>
    <name>Q6FTT2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein kinase SCH9</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0F09075g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTT2"/>
    <dbReference type="FunCoup" id="Q6FTT2">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTT2"/>
    <dbReference type="KEGG" id="cgr:2887850"/>
    <dbReference type="CGD" id="CAL0129548">
        <property type="gene designation" value="CAGL0F09075g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F09075g"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_52_2_1"/>
    <dbReference type="InParanoid" id="Q6FTT2"/>
    <dbReference type="OMA" id="SYAMGTT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904828">
        <property type="term" value="P:positive regulation of hydrogen sulfide biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901494">
        <property type="term" value="P:regulation of cysteine metabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047484">
        <property type="term" value="P:regulation of response to osmotic stress"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090153">
        <property type="term" value="P:regulation of sphingolipid biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000116">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
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        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="142"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="340"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="15">
        <location>
            <begin position="600"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="99"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="691"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <begin position="719"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0129548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG59286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="746" mass="83800" checksum="99F3EB0024522187" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTX2</accession>
    <name>Q6FTX2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SDA1</name>
        <name evidence="11 12" type="ordered locus">CAGL0F08129g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446322.1">
        <property type="nucleotide sequence ID" value="XM_446322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTX2"/>
    <dbReference type="FunCoup" id="Q6FTX2">
        <property type="interactions" value="1214"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTX2"/>
    <dbReference type="GeneID" id="2887946"/>
    <dbReference type="KEGG" id="cgr:2887946"/>
    <dbReference type="CGD" id="CAL0129292">
        <property type="gene designation" value="SDA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08129g"/>
    <dbReference type="eggNOG" id="KOG2229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009161_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FTX2"/>
    <dbReference type="OMA" id="AMYKTYK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007089">
        <property type="term" value="P:traversing start control point of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="84"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="545"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="697"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="674"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="586"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="674"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="708"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="732"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0129292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="745" mass="84581" checksum="CCE60E1C0BDC399B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-06-18" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTX7</accession>
    <name>PEX21_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Peroxisomal protein PEX21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Peroxin-21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PEX21</name>
        <name type="ordered locus">CAGL0F08019g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (By similarity). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (By similarity). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX21.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with PEX7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
        <text evidence="2">Cycles between the cytosol and the peroxisome.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Monoubiquitinated at Cys-5; acts as a signal for PEX21 extraction and is required for proper export from peroxisomes and recycling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxin-21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446317.1">
        <property type="nucleotide sequence ID" value="XM_446317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTX7"/>
    <dbReference type="SMR" id="Q6FTX7"/>
    <dbReference type="FunCoup" id="Q6FTX7">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTX7"/>
    <dbReference type="EnsemblFungi" id="CAGL0F08019g-T">
        <property type="protein sequence ID" value="CAGL0F08019g-T-p1"/>
        <property type="gene ID" value="CAGL0F08019g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887900"/>
    <dbReference type="KEGG" id="cgr:2887900"/>
    <dbReference type="CGD" id="CAL0131384">
        <property type="gene designation" value="PEX21"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08019g"/>
    <dbReference type="eggNOG" id="ENOG502S8JP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1194755_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTX7"/>
    <dbReference type="OMA" id="NENSTIM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056940">
        <property type="entry name" value="PEX18_PEX21_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25098">
        <property type="entry name" value="PEX18_PEX21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0576">Peroxisome</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0882">Thioester bond</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000301808" description="Peroxisomal protein PEX21">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl cysteine thioester (Cys-Gly) (interchain with G-Cter in ubiquitin)" evidence="1">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P35056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P50091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P50542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="232" mass="26704" checksum="91FA0948845A3CEC" modified="2004-07-19" version="1">MSQYCAADPIQRMVSRKGPYLDTQQQRVYKHRSGTGHGTNIRQPTTGIVEATFLQNNSGMNAVHPTTLNVQTHNAHATGRTIAKSVDTNSWVNDFSSMKVQDPLEFADSYKNLYKQYEQKQFHNTVPAQCPRNLYIPTVTRPQTTLNIVDHHEDKSSAVDQLIDDEFEKIEEEVKDQNQKLEFQESAQSFIEICERSQMKEKLQRSKFFQVMQKVSDGEATIRQDGENYVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTY3</accession>
    <name>Q6FTY3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0F07887g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTY3"/>
    <dbReference type="FunCoup" id="Q6FTY3">
        <property type="interactions" value="1462"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTY3"/>
    <dbReference type="KEGG" id="cgr:2887635"/>
    <dbReference type="CGD" id="CAL0130870">
        <property type="gene designation" value="CAGL0F07887g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07887g"/>
    <dbReference type="eggNOG" id="KOG0360">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_3_1"/>
    <dbReference type="InParanoid" id="Q6FTY3"/>
    <dbReference type="OMA" id="RGPNDYQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0130870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="559" mass="60415" checksum="FFC50247AF5FC9BD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTY9</accession>
    <accession>Q5VLI2</accession>
    <name>Q6FTY9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CEP3</name>
        <name evidence="4 5" type="ordered locus">CAGL0F07755g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446305.1">
        <property type="nucleotide sequence ID" value="XM_446305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTY9"/>
    <dbReference type="SMR" id="Q6FTY9"/>
    <dbReference type="FunCoup" id="Q6FTY9">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTY9"/>
    <dbReference type="GeneID" id="2887796"/>
    <dbReference type="KEGG" id="cgr:2887796"/>
    <dbReference type="CGD" id="CAL0129221">
        <property type="gene designation" value="CEP3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07755g"/>
    <dbReference type="eggNOG" id="ENOG502QVHC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457054_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTY9"/>
    <dbReference type="OMA" id="WQSYEYW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031518">
        <property type="term" value="C:CBF3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12147">
        <property type="entry name" value="Cep3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031760">
        <property type="entry name" value="Cep3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16846">
        <property type="entry name" value="Cep3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0129221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="611" mass="70973" checksum="55B000280F671C8B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU07</accession>
    <name>Q6FU07_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0F07359g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU07"/>
    <dbReference type="FunCoup" id="Q6FU07">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887907"/>
    <dbReference type="CGD" id="CAL0130988">
        <property type="gene designation" value="CAGL0F07359g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07359g"/>
    <dbReference type="HOGENOM" id="CLU_1053742_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU07"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0130988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="264" mass="30913" checksum="B4260FDB850CFA58" modified="2004-07-19" version="1">MMQFNVRSPVVKAREETYLKKIERVFNVDKISTHDLLRLETVHLCDPLQFFTNGLLESLMYPDGKFLVHHVATSKKLVQDSISIDQALQLGHPKMLELIYLRDRIGSIRGKMDVENSKLNQTIIENLQEVHALVMAIYTEFKEHLKVRLYKDFYGFVLKEQKENFHTVLQMIQKYINIVEKTKQAITPESLLSSMKSFNVELSIVADKLVKNSRCFKEYTDVINAGSENLLFNANDQFDLADVEFQQFYKERLDRLKISARRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU98</accession>
    <name>Q6FU98_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0F05159g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU98"/>
    <dbReference type="FunCoup" id="Q6FU98">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU98"/>
    <dbReference type="KEGG" id="cgr:2887736"/>
    <dbReference type="CGD" id="CAL0130898">
        <property type="gene designation" value="CAGL0F05159g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05159g"/>
    <dbReference type="eggNOG" id="KOG2897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018782_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU98"/>
    <dbReference type="OMA" id="CQYFDPK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="724"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0130898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="795" mass="90965" checksum="50527059E1A365CD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUC5</accession>
    <name>Q6FUC5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0F04543g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446169.1">
        <property type="nucleotide sequence ID" value="XM_446169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUC5"/>
    <dbReference type="KEGG" id="cgr:2887970"/>
    <dbReference type="CGD" id="CAL0131136">
        <property type="gene designation" value="CAGL0F04543g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04543g"/>
    <dbReference type="HOGENOM" id="CLU_2426787_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUC5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0131136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="91" mass="10542" checksum="4D261EB6420CF2A4" modified="2004-07-19" version="1">MHRILCRGGIQFPPTIITISEKGNFISNVARSYISMKAIFSGMLPCRNSLTFFFTDFLDGYNELRNVCNEKPQYRLKNFQDPYPIQQVAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUJ8</accession>
    <name>Q6FUJ8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide hydrolase</fullName>
            <ecNumber evidence="9">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0F02893g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446096.1">
        <property type="nucleotide sequence ID" value="XM_446096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUJ8"/>
    <dbReference type="FunCoup" id="Q6FUJ8">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUJ8"/>
    <dbReference type="MEROPS" id="M28.006"/>
    <dbReference type="KEGG" id="cgr:2887577"/>
    <dbReference type="CGD" id="CAL0131302">
        <property type="gene designation" value="CAGL0F02893g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02893g"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025866_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUJ8"/>
    <dbReference type="OMA" id="GMLQQDM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03879">
        <property type="entry name" value="M28_AAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000042">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="10">
        <location>
            <begin position="161"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0131302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="377" mass="42687" checksum="21412B7876681E04" modified="2004-07-19" version="1">MLLKNLVYIGSVAALPWSSSWSSLLQDDDSVRTIDVGDGQLRQVTEYDKLKLRRRGIKFFDVTDVLFFRSEEDPVVADYNYPMQMHQRDTVHGVLDKIDKESMYADLSKLTSFYTRYYKSAEGVKSADWVLSRITNITNGLEKDLVQIEQVSHKGWDQYSIVVRFKGTSLPDNIVVIGSHHDSINLLLPSVLPAPGADDNGSGTTTVLEALRVYVEYYIKQNQRPMNTIEFHFYSAEEGGLLGSLDVFTRYARDQKKVVAMLQQDMTGYVRDPAKEHVGLVTDHTTPKLNNFLKLVMNEFLSIPYVETECGYACSDHGSAVKNGFPAAFVIESDFKKTNRYIHSTMDTLDRLSLDHMAEHAKLVLGTVIELGQWLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUP7</accession>
    <name>Q6FUP7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0F01727g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oligoribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUP7"/>
    <dbReference type="FunCoup" id="Q6FUP7">
        <property type="interactions" value="804"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUP7"/>
    <dbReference type="KEGG" id="cgr:2887971"/>
    <dbReference type="CGD" id="CAL0131208">
        <property type="gene designation" value="CAGL0F01727g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01727g"/>
    <dbReference type="eggNOG" id="KOG3242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064761_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FUP7"/>
    <dbReference type="OMA" id="AFFHYRN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000003">
        <property type="entry name" value="Oligoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11046:SF0">
        <property type="entry name" value="OLIGORIBONUCLEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="6">
        <location>
            <begin position="39"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0131208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="250" mass="29009" checksum="169964867F40FD6B" modified="2004-07-19" version="1">MFRSGIGRALSYLSRTQAKSQPYLLKPKLRKMETSNTKPLVWIDCEMTGLDHVNDEIIEICCIVTDGELKNLDTETKEQCYESVVHCPKEKLDAMDQWCLDHHGSSGLMDKVLASKKTKEQVEEELLNYLQKWIPEKRVGILAGNSVHMDRLFMLKDFPRVVQYLHYRIVDVSSIMEVARRHNPSLTAVVPKKEAAHTAKSDILESISQLQWYMDHYLKSEEETKEFVESQNEKRPSEEPIDQPQKKQCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV58</accession>
    <name>Q6FV58_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0E04554g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445886.1">
        <property type="nucleotide sequence ID" value="XM_445886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV58"/>
    <dbReference type="KEGG" id="cgr:2887474"/>
    <dbReference type="CGD" id="CAL0128620">
        <property type="gene designation" value="CAGL0E04554g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04554g"/>
    <dbReference type="HOGENOM" id="CLU_1156244_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FV58"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="240" mass="27822" checksum="58D7B30DC9444DFB" modified="2004-07-19" version="1">MKNFIKKKHKKMSLAIQTPESLISDDFGYTQPKRFNYLDTFSNLSRNTSLTSLKSSSRVSSDYSYRPRDETLKKPDCDGILDNKNSSQIRTVPTLCSSDKLSRCDKSTMKYHKKSESDEFEQFTSPDLHFEAIDSISVNNISDNVYESHTDLNSYQQDEEYENSDDESNTGLSSYFAPIYYGLNSNTFFQPSFDTLFDAEKKARSYTFGFDDFRIKKPSKKTVNNFVRLMQQKRHNTKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVA4</accession>
    <name>Q6FVA4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0E03520g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVA4"/>
    <dbReference type="FunCoup" id="Q6FVA4">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVA4"/>
    <dbReference type="KEGG" id="cgr:2887469"/>
    <dbReference type="CGD" id="CAL0128882">
        <property type="gene designation" value="CAGL0E03520g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E03520g"/>
    <dbReference type="eggNOG" id="ENOG502RXWY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088025_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVA4"/>
    <dbReference type="OMA" id="LHKGPRV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="76"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="226" mass="24959" checksum="A5032A5699683EF2" modified="2004-07-19" version="1">MGMGPTTAQQDRLTMSMIGRRWYMHAGARVRGLRRDPVSYLKNPAGLVYTDVGGDYHASVRERMGFQEHGIELSDAAILQCLTHKSFAHGSRPYNEKLNLLGSQYLKLQAAMHSVGPENSFGNLGTPVSKGLVSYQTAAEYVIAKNLEPLVFWKVSDPLNDGPIKGKSKVMSTVLNSFIGAILLQQGEKKASQFIVEDLLNPSNTQSLLNITLRKLDQQKETVHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVC1</accession>
    <name>Q6FVC1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0E03069g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in rRNA-processing and ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the 90S pre-ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58742.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVC1"/>
    <dbReference type="FunCoup" id="Q6FVC1">
        <property type="interactions" value="1347"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVC1"/>
    <dbReference type="KEGG" id="cgr:2887366"/>
    <dbReference type="CGD" id="CAL0128576">
        <property type="gene designation" value="CAGL0E03069g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E03069g"/>
    <dbReference type="eggNOG" id="KOG2321">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009923_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVC1"/>
    <dbReference type="OMA" id="GYFMDVR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000537">
        <property type="entry name" value="Ribosome biogenesis protein ENP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="14">
        <location>
            <begin position="79"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="13">
        <location>
            <begin position="432"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="12">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="585"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="618"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="730"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0128576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG58742.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="754" mass="86468" checksum="8C0438152E51705A" modified="2008-09-23" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVC9</accession>
    <name>Q6FVC9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase I-specific transcription initiation factor RRN6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0E02893g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVC9"/>
    <dbReference type="FunCoup" id="Q6FVC9">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVC9"/>
    <dbReference type="KEGG" id="cgr:2887424"/>
    <dbReference type="CGD" id="CAL0128922">
        <property type="gene designation" value="CAGL0E02893g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02893g"/>
    <dbReference type="eggNOG" id="ENOG502QRAW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014997_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVC9"/>
    <dbReference type="OMA" id="PAFTLMQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001179">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001163">
        <property type="term" value="F:RNA polymerase I transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019350">
        <property type="entry name" value="RNA_pol_I-sp_TIF_RRN6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016531">
        <property type="entry name" value="Rrn6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048535">
        <property type="entry name" value="RRN6_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048537">
        <property type="entry name" value="RRN6_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048536">
        <property type="entry name" value="Rrn6_K-rich"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28221:SF2">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10214">
        <property type="entry name" value="Rrn6_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20640">
        <property type="entry name" value="Rrn6_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20639">
        <property type="entry name" value="Rrn6_K-rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007939">
        <property type="entry name" value="RNA_pol_I_RRN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRN6 beta-propeller" evidence="2">
        <location>
            <begin position="209"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 helical bundle" evidence="4">
        <location>
            <begin position="658"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="RRN6 K-rich C-terminal" evidence="3">
        <location>
            <begin position="813"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="871"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0128922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG58734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="930" mass="106695" checksum="36C7D59AE923CAC6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVQ8</accession>
    <name>UBC12_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber>2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Ubiquitin carrier protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">UBC12</name>
        <name type="ordered locus">CAGL0D06468g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accepts the ubiquitin-like protein NEDD8/RUB1 from the UBA3-ULA1 E1 complex and catalyzes its covalent attachment to other proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445686.1">
        <property type="nucleotide sequence ID" value="XM_445686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVQ8"/>
    <dbReference type="SMR" id="Q6FVQ8"/>
    <dbReference type="FunCoup" id="Q6FVQ8">
        <property type="interactions" value="867"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVQ8"/>
    <dbReference type="EnsemblFungi" id="CAGL0D06468g-T">
        <property type="protein sequence ID" value="CAGL0D06468g-T-p1"/>
        <property type="gene ID" value="CAGL0D06468g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886969"/>
    <dbReference type="KEGG" id="cgr:2886969"/>
    <dbReference type="CGD" id="CAL0128479">
        <property type="gene designation" value="CAGL0D06468g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_D06468g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D06468g"/>
    <dbReference type="eggNOG" id="KOG0420">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_6_0_1"/>
    <dbReference type="InParanoid" id="Q6FVQ8"/>
    <dbReference type="OMA" id="YDNIVSP"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000082497" description="NEDD8-conjugating enzyme UBC12">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="32"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2 3">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="187" mass="21004" checksum="94B94002BFB0AB9C" modified="2004-07-19" version="1">MLKLRQLQQQKQQQLAKNAGSSVKANTNSTSPAKLRLQKDIEELELPPTVRVNIISLDNHKEMSLNIIIIPDEGFYKGGKFRFTATFLETYPIDPPKVICNNKIFHPNIDPHGKICLNILREDWSPALDLQCIVLGLLSLFQEPNGNDPLNKEAAEVLNKDKLEFGNLVRLAMSGAMVGSTYYECVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW35</accession>
    <name>Q6FW35_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome chaperone 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0D03278g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW35"/>
    <dbReference type="FunCoup" id="Q6FW35">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW35"/>
    <dbReference type="KEGG" id="cgr:2887020"/>
    <dbReference type="CGD" id="CAL0128443">
        <property type="gene designation" value="CAGL0D03278g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03278g"/>
    <dbReference type="eggNOG" id="ENOG502S42X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133914_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW35"/>
    <dbReference type="OMA" id="CTQIAEL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018854">
        <property type="entry name" value="Psome_chaperone_3/4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10448">
        <property type="entry name" value="POC3_POC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18926" checksum="80C7C1C68A03509D" modified="2004-07-19" version="1">MQVRSIRRKLDAQIDAAEGEVAVKALHYSNSVVLQIRYNGEFDSTYEVNSVGLRPGSMTNGRPLALNTYASEDNSQNGGSGEIDEETEEPTDYLADYKVVVRLGNGDDPKMNIVCSQIAELYNQMQGGDELRGVNLVISLSRKLWKGEDSHSRDFAVLVFLLQCIKDMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW45</accession>
    <name>Q6FW45_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0D03058g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW45"/>
    <dbReference type="FunCoup" id="Q6FW45">
        <property type="interactions" value="1065"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW45"/>
    <dbReference type="MEROPS" id="T01.010"/>
    <dbReference type="KEGG" id="cgr:2887235"/>
    <dbReference type="CGD" id="CAL0128239">
        <property type="gene designation" value="CAGL0D03058g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03058g"/>
    <dbReference type="eggNOG" id="KOG0174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_5_2_1"/>
    <dbReference type="InParanoid" id="Q6FW45"/>
    <dbReference type="OMA" id="TFIYGYC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0128239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG58460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="215" mass="23626" checksum="55B207780E9C534F" modified="2004-07-19" version="1">MDGVQVDITALKKGEVSLGTSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDNIWCCRSGSAADTQAVADIVQYYLDMYEGQFGEPDTYTAANMFKTLCYQNKDALTAGIIVAGYDEKNKGEVYSIPLGGSIHKQPYAIAGSGSTFIYGYCDKNFRENMSKDETIDFIKHSLSQAIKWDGSSGGVIRMVVLTKDGPERLIFYPEEYENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW92</accession>
    <name>Q6FW92_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0D02024g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW92"/>
    <dbReference type="FunCoup" id="Q6FW92">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW92"/>
    <dbReference type="KEGG" id="cgr:2887026"/>
    <dbReference type="CGD" id="CAL0128035">
        <property type="gene designation" value="CAGL0D02024g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02024g"/>
    <dbReference type="eggNOG" id="ENOG502S81F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141719_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW92"/>
    <dbReference type="OMA" id="KYTVFDR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="130" mass="15495" checksum="FC448B03F274F772" modified="2004-07-19" version="1">MFGPFRGTQFLQGGLLWKVPWRMSGPQKFRQRQRLKAVDDVVKNLTLGLHVQRCQEKGLQFEQALEERKYKPRSAIMRLLNKASFFPKEYQMSAKDKYTVFDKKSRGYRKGIHKVPKWTKISARRNPQFF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWA7</accession>
    <name>TFB4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName>TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TFB4</name>
        <name type="ordered locus">CAGL0D01650g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TFB4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445487.1">
        <property type="nucleotide sequence ID" value="XM_445487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWA7"/>
    <dbReference type="SMR" id="Q6FWA7"/>
    <dbReference type="FunCoup" id="Q6FWA7">
        <property type="interactions" value="1222"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWA7"/>
    <dbReference type="EnsemblFungi" id="CAGL0D01650g-T">
        <property type="protein sequence ID" value="CAGL0D01650g-T-p1"/>
        <property type="gene ID" value="CAGL0D01650g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887225"/>
    <dbReference type="KEGG" id="cgr:2887225"/>
    <dbReference type="CGD" id="CAL0128459">
        <property type="gene designation" value="CAGL0D01650g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_D01650g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01650g"/>
    <dbReference type="eggNOG" id="KOG2487">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040211_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWA7"/>
    <dbReference type="OMA" id="QGCDITS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000093">
        <property type="entry name" value="Transcription initiation factor TFIIH subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000119270" description="General transcription and DNA repair factor IIH subunit TFB4">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q12004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="335" mass="37342" checksum="3C07A8E3F26D2149" modified="2004-07-19" version="1">MDAIADPNFQQTKLRSTATEDIPSLLTVVLDISPRLWAEFDHRSGEKQSVTTVLKSLIVFLNSHLAFNSANQVAVIAAFSQGIQYLYPRSSDTSEQNAGNSKDLSIISSHMYRRFRNVDETLIEEFYKLYQREESLIDKPVQKSTLSGAMAAALTYTNRLTKEFESISLRSRLLVITCGSSREKDEIFQYIPIMNCIFSATKLKCPIDVIKIGGNKQSTFLQQTTDATNGVYIHLESTNGIIQYLSTAMSIDPSLRQIIVRPTQGSVDFRTSCYLTGKVVAIGYICSVCLCVLSIIPPGNKCPACDSQFDERVIAKLKKKPVVPKSTLKKVKKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWL1</accession>
    <name>Q6FWL1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0C04829g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445383.1">
        <property type="nucleotide sequence ID" value="XM_445383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWL1"/>
    <dbReference type="FunCoup" id="Q6FWL1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886827"/>
    <dbReference type="CGD" id="CAL0127368">
        <property type="gene designation" value="CAGL0C04829g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04829g"/>
    <dbReference type="eggNOG" id="ENOG502SBGJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2145547_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWL1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12633" checksum="60D34E423B7819FC" modified="2004-07-19" version="1">MMVASKYIHLPRFRTIQSPNDDIEMVTNRIPLENGTTNAESTTYYQVNKYIIATVICCGFAGIASELFQKIASHNKRSFDVYDIYFDMMGSGCGIIAAYLHESYSNRISIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWR5</accession>
    <name>Q6FWR5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0C03509g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWR5"/>
    <dbReference type="FunCoup" id="Q6FWR5">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWR5"/>
    <dbReference type="KEGG" id="cgr:2886729"/>
    <dbReference type="CGD" id="CAL0127406">
        <property type="gene designation" value="CAGL0C03509g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03509g"/>
    <dbReference type="eggNOG" id="KOG0610">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_84_2_1"/>
    <dbReference type="InParanoid" id="Q6FWR5"/>
    <dbReference type="OMA" id="SHRAFFK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000370">
        <property type="term" value="P:positive regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061092">
        <property type="term" value="P:positive regulation of phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000749">
        <property type="term" value="P:response to pheromone triggering conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001236">
        <property type="entry name" value="AGC/RSK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000121">
        <property type="entry name" value="Serine/threonine-protein kinase nrc-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="497"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="779"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="93"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0127406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG58235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="895" mass="99866" checksum="06B6AC46EA202AE6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWT5</accession>
    <name>Q6FWT5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0C03025g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWT5"/>
    <dbReference type="FunCoup" id="Q6FWT5">
        <property type="interactions" value="818"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWT5"/>
    <dbReference type="KEGG" id="cgr:2886728"/>
    <dbReference type="CGD" id="CAL0127178">
        <property type="gene designation" value="CAGL0C03025g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03025g"/>
    <dbReference type="eggNOG" id="KOG2570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032070_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWT5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="389"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="482" mass="54299" checksum="ACE35DC4DC75F4E8" modified="2004-07-19" version="1">MPENSDAVKTAPIPTSAPTYTYIPFELKEDVPELALLQKLVEKEKQLDISVREKENQLSLDATSGGLYPQNTSDSGRLLRVYVYNTAHHQPWQDEKTDDKPHWLLRVEGKLLNRDGSEVQGESRPFSSYLQAVAVDFKKFKPRRQDNRPEIVSNGDITMTDGDNTTQQLAENANSTNMATNDNDDDDDEDEDAEDDSEIIDAVEWHYDSVAGSEFDGIDVKRPGTQNINCTITIQPRGCTGEEVEYSPELSQILGINVGSVQGAVYGLYKYILNNNLLNNEGKTNDNQHMSSNNSESTKVTLDSALHKLLPKRDITEQAMANTEELKVGLKEAMSLVNDHFQPLPAKKINYTIRTDVETTYGQTVFDIEIGNESPEVKETPLSRFRELAKTTDQEVEDIDEQINMLQLQLNALATKHQFFKETEKNPLAVLKEYALISKNATEVLASDLQFTEDSVRLSDFYKENEALLFENLATYIANSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWW1</accession>
    <name>Q6FWW1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTP-binding protein YPT31/YPT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0C02453g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWW1"/>
    <dbReference type="FunCoup" id="Q6FWW1">
        <property type="interactions" value="1031"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWW1"/>
    <dbReference type="KEGG" id="cgr:2886855"/>
    <dbReference type="CGD" id="CAL0127334">
        <property type="gene designation" value="CAGL0C02453g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02453g"/>
    <dbReference type="eggNOG" id="KOG0087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_2_1"/>
    <dbReference type="InParanoid" id="Q6FWW1"/>
    <dbReference type="OMA" id="FAENHTM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0127334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23947" checksum="A7CA1B151C695709" modified="2004-07-19" version="1">MSNEDYGYDYDYLFKIVLIGDSGVGKSNLLSRFTTNEFNIDSKSTIGVEFATRTIDVDGKKIKAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKSSSYENCHHWLSELRENADDNVAVGLIGNKSDLAHLRAVPTEEAKQFASENQLLFTETSALNSDNVDLAFKELITAIHQKVSKHQVELSNANKPGAGPNGPTISLTPAPNEKKKSSSNNCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWX4</accession>
    <name>Q6FWX4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Outer spore wall protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0C02167g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWX4"/>
    <dbReference type="FunCoup" id="Q6FWX4">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886910"/>
    <dbReference type="CGD" id="CAL0127596">
        <property type="gene designation" value="CAGL0C02167g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02167g"/>
    <dbReference type="eggNOG" id="ENOG502S2G3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_522810_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWX4"/>
    <dbReference type="OMA" id="DINCTSK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273524" description="Outer spore wall protein 7" evidence="2">
        <location>
            <begin position="22"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="55242" checksum="DAE7DD967B5E697E" modified="2004-07-19" version="1">MARGLFLVVLVAASVLLGVLYRDPMTPGCMDMIKYTGYQSTSVPYLAVLIELLLDMWGKVVEFVHRNRLCCTLHRKLGPLLQHLRIVLYYLKPFAQQASSSFNDGFAILRGNLDFSRIDEGYSMLSLINNGRNVIESDEEDEDEEDGDEKSTKNKKQSKNKEQAESSNVDAIVDAVLNDPTDVTLHKDTDDSAVQFPQLSELINTEVLLQEGGFNIWVKSISRKFKAIENELSQEVDNTISSTVVSGVENFQKDIEELRSDMDAQISILKDTVQNINCTMIYDENTDSVFYYDHTGQKLLDTYVTRPLIMHHLKSTETRLEQLVEAVKLQVENMVEQSHIALEAVRNETIEAYEEWGDTFYTEWSKYMAYRDIYDEDGEEPRPLAIDGKGKGEDQGDDEVAKIYEDWFEFTLHKKDIIQFRDQLLHKQLDTKKLKQFETSLDSQLDSLEKTYTAQIQSLRSQADRLLKDRDHKEAQMFKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX35</accession>
    <name>ATG14_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ATG14</name>
        <name type="ordered locus">CAGL0C00627g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="Cell. Microbiol." volume="17" first="269" last="287">
            <title>An essential role for phosphatidylinositol 3-kinase in the inhibition of phagosomal maturation, intracellular survival and virulence in Candida glabrata.</title>
            <authorList>
                <person name="Rai M.N."/>
                <person name="Sharma V."/>
                <person name="Balusu S."/>
                <person name="Kaur R."/>
            </authorList>
            <dbReference type="PubMed" id="25223215"/>
            <dbReference type="DOI" id="10.1111/cmi.12364"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="2 4">Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I (By similarity). This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. ATG14 mediates the specific binding of the VPS34 PI3-kinase complex I to the preautophagosomal structure (PAS) (By similarity). Required for survival and/or proliferation in kidneys and in brain (PubMed:25223215).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the autophagy-specific VPS34 PI3-kinase complex I composed of VPS15, VPS30, VPS34, ATG14 and ATG38. Interacts directly with ATG38.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">Coiled-Coils at the N-terminal half are essential for interaction with VPS30 and VPS34 and autophagy.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">leads to seven- to eightfold decrease of the renal fungal load and four-fold lower fungal burden in the brain of infected mice (PubMed:25223215). Does not affect protein trafficking (PubMed:25223215).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445209.1">
        <property type="nucleotide sequence ID" value="XM_445209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX35"/>
    <dbReference type="SMR" id="Q6FX35"/>
    <dbReference type="FunCoup" id="Q6FX35">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX35"/>
    <dbReference type="EnsemblFungi" id="CAGL0C00627g-T">
        <property type="protein sequence ID" value="CAGL0C00627g-T-p1"/>
        <property type="gene ID" value="CAGL0C00627g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886881"/>
    <dbReference type="KEGG" id="cgr:2886881"/>
    <dbReference type="CGD" id="CAL0127632">
        <property type="gene designation" value="ATG14"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00627g"/>
    <dbReference type="eggNOG" id="ENOG502RY86">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069448_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX35"/>
    <dbReference type="OMA" id="MYCSHCI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120095">
        <property type="term" value="C:vacuole-isolation membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051365">
        <property type="term" value="P:cellular response to potassium ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023261">
        <property type="entry name" value="Autophagy-related_protein_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018791">
        <property type="entry name" value="UV_resistance/autophagy_Atg14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10186">
        <property type="entry name" value="ATG14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02030">
        <property type="entry name" value="AUTOPHGYRP14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000212451" description="Autophagy-related protein 14">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cysteine repeats" evidence="1">
        <location>
            <begin position="5"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P38270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="25223215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="25223215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="364" mass="42604" checksum="316BF71569E6F730" modified="2004-07-19" version="1">MGMQCPICETQSHVFYCAHCINSSPDLLIRLKFDLYILGKINNALRNKVDQYLEEVDDELNTNIRNGEQLESNIGVQILKERLGKVQVLRKERQNNKIKHKISQQDRRIKEKSRYIAELRSLINGPPKNQNRFTDPQTILKAQKQLQDKLEIAKRLSIQTRSEKLAMLNKWYSIRKRDSHDIPFTISYQPVISLKNFNRLPLPLIEGSLRKLIQYMNLLEHIYCIKYPSAMFVHEDEMLSLQGHSAKLKRNAPELLQVLIKLIQMILVVMTRSKLIDERKQNIDYAWILDQYDIDGLFYHMAMSIPIDTKSGAKNIQWSTDRLVDIVCSSLGAEKEEVLLKDHKKLEPPTDKKYEVSDRWYIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX39</accession>
    <name>Q6FX39_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0C00539g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58109.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX39"/>
    <dbReference type="FunCoup" id="Q6FX39">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886764"/>
    <dbReference type="CGD" id="CAL0127610">
        <property type="gene designation" value="CAGL0C00539g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00539g"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="Q6FX39"/>
    <dbReference type="OMA" id="NTIIHYW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902274">
        <property type="term" value="P:positive regulation of (R)-carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902269">
        <property type="term" value="P:positive regulation of polyamine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="86"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0127610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58109.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="593" mass="67149" checksum="2B92FB2C4E0EA481" modified="2008-09-23" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXD5</accession>
    <name>Q6FXD5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAGL0B01793g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57947.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXD5"/>
    <dbReference type="STRING" id="284593.Q6FXD5"/>
    <dbReference type="KEGG" id="cgr:2886716"/>
    <dbReference type="eggNOG" id="KOG4612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FXD5"/>
    <dbReference type="OMA" id="LARMTNK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG57947.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="98" mass="11319" checksum="DDA999C0FC7F80E5" modified="2008-09-23" version="2">MLSSSFGVLRPMNLTPGNGMIGKNSVSLIRNEISSGTSFSSILTLFPLQRRWKSRGNTYQPSTLKRKRKFGFLARMTNKRTAKIIKRRKEKGRWYLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXK1</accession>
    <name>Q6FXK1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0B03289g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXK1"/>
    <dbReference type="FunCoup" id="Q6FXK1">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXK1"/>
    <dbReference type="KEGG" id="cgr:2886517"/>
    <dbReference type="CGD" id="CAL0127886">
        <property type="gene designation" value="CAGL0B03289g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03289g"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008535_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXK1"/>
    <dbReference type="OMA" id="HATVCVD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05677">
        <property type="entry name" value="M20_dipept_like_DUG2_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="620"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0127886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="870" mass="97198" checksum="2CE60CD8E6473E19" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY71</accession>
    <name>Q6FY71_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RIC1 C-terminal alpha solenoid region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0A03564g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY71"/>
    <dbReference type="FunCoup" id="Q6FY71">
        <property type="interactions" value="169"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY71"/>
    <dbReference type="KEGG" id="cgr:2886282"/>
    <dbReference type="CGD" id="CAL0126593">
        <property type="gene designation" value="CAGL0A03564g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A03564g"/>
    <dbReference type="eggNOG" id="KOG2006">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_325467_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY71"/>
    <dbReference type="OMA" id="WDMCFQL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="3">
        <location>
            <begin position="792"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0126593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG57815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="993" mass="114448" checksum="CE709F21E6EDA9F6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B4UMZ8</accession>
    <name>B4UMZ8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine-rich transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0F05329g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYSTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAR58022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UMZ8"/>
    <dbReference type="FunCoup" id="B4UMZ8">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:9487989"/>
    <dbReference type="CGD" id="CAL0131108">
        <property type="gene designation" value="CAGL0F05329g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05329g"/>
    <dbReference type="HOGENOM" id="CLU_156676_1_0_1"/>
    <dbReference type="InParanoid" id="B4UMZ8"/>
    <dbReference type="OMA" id="EESCECC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028144">
        <property type="entry name" value="CYSTM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12734">
        <property type="entry name" value="CYSTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich transmembrane" evidence="5">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0131108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAR58022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="67" mass="7677" checksum="8672CAB5E9B6BDD6" modified="2008-09-23" version="1">MSQQYYQQGPPPPQQGYYQQGPPPQQGYYQQQPVYVQQAPPQKESSCMDQCLKLLCCCFLLELVCGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN31</accession>
    <name>B4UN31_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0J07980g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAR58047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN31"/>
    <dbReference type="FunCoup" id="B4UN31">
        <property type="interactions" value="618"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UN31"/>
    <dbReference type="KEGG" id="cgr:9488025"/>
    <dbReference type="CGD" id="CAL0132760">
        <property type="gene designation" value="CAGL0J07980g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07980g"/>
    <dbReference type="eggNOG" id="KOG1603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134973_3_1_1"/>
    <dbReference type="InParanoid" id="B4UN31"/>
    <dbReference type="OMA" id="MTHTYKF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0132760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAR58047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="74" mass="8303" checksum="75D610473923F6DA" modified="2008-09-23" version="1">MSENQNHYQFDVVMTCSGCSSAVERVLKKLEPDVSHIDISLPQQTVDVYTTLPYETILEKIKKTGKEVKSGTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN57</accession>
    <name>B4UN57_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M03305g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAR58073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN57"/>
    <dbReference type="FunCoup" id="B4UN57">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:9488056"/>
    <dbReference type="CGD" id="CAL0136875">
        <property type="gene designation" value="CAGL0M03305g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03305g"/>
    <dbReference type="eggNOG" id="ENOG502SFZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_219858_0_0_1"/>
    <dbReference type="InParanoid" id="B4UN57"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012589">
        <property type="entry name" value="Pmp1/Pmp2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08114">
        <property type="entry name" value="PMP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAR58073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="39" mass="4350" checksum="48C2C229F9F70C63" modified="2008-09-23" version="1">MLPGGPIVVLILVGLAACIIVATIIYRKWQERQRALARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIJ3</accession>
    <name>Q6FIJ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongator complex protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M13959g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIJ3"/>
    <dbReference type="FunCoup" id="Q6FIJ3">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIJ3"/>
    <dbReference type="KEGG" id="cgr:2891613"/>
    <dbReference type="CGD" id="CAL0136315">
        <property type="gene designation" value="CAGL0M13959g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13959g"/>
    <dbReference type="eggNOG" id="ENOG502S4WT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086730_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIJ3"/>
    <dbReference type="OMA" id="EYVYHIT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19495">
        <property type="entry name" value="Elp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018627">
        <property type="entry name" value="ELP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16184:SF6">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0136315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29360" checksum="0956DD4581EDEB96" modified="2004-07-19" version="1">MVQRQDLVLFSDHTVVSDKLFDSQENVVINVTSTQATQATWLNTVLMESYLLGSPVSLNSEQKSSVAQVRNGKWITVASLVHNTGFFQANFNRLQVDSSHYKIVDLLTDFVQLISGKPTEKILLTLLDMFPENRNGMIIIEQPEILLSLIPNLTADILGSKFINALRKKCGLLVINSVIDPVQEDIETSTAVEFKRFLQANIYKSQALIALNPLPTGRAKDVTGTLRISRGPSSIQGIIPDLQIAENEYLYLTDKDNTELFYS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIP2</accession>
    <name>RPN2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPN2</name>
        <name type="ordered locus">CAGL0M12859g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449902.1">
        <property type="nucleotide sequence ID" value="XM_449902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIP2"/>
    <dbReference type="SMR" id="Q6FIP2"/>
    <dbReference type="FunCoup" id="Q6FIP2">
        <property type="interactions" value="1541"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIP2"/>
    <dbReference type="EnsemblFungi" id="CAGL0M12859g-T">
        <property type="protein sequence ID" value="CAGL0M12859g-T-p1"/>
        <property type="gene ID" value="CAGL0M12859g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891453"/>
    <dbReference type="KEGG" id="cgr:2891453"/>
    <dbReference type="CGD" id="CAL0136353">
        <property type="gene designation" value="CAGL0M12859g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M12859g"/>
    <dbReference type="eggNOG" id="KOG2062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002323_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIP2"/>
    <dbReference type="OMA" id="IMFGRQE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0647">Proteasome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000173806" description="26S proteasome regulatory subunit RPN2">
        <location>
            <begin position="1"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 1">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 2">
        <location>
            <begin position="400"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 3">
        <location>
            <begin position="442"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 4">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 5">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 6">
        <location>
            <begin position="547"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 7">
        <location>
            <begin position="583"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 8">
        <location>
            <begin position="617"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 9">
        <location>
            <begin position="652"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="PC 10">
        <location>
            <begin position="695"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="808"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="941" mass="104059" checksum="FE8EE869E7AEC8A8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIU0</accession>
    <name>GIP4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>GLC7-interacting protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">GIP4</name>
        <name type="ordered locus">CAGL0M11792g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with GLC7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GIP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449854.1">
        <property type="nucleotide sequence ID" value="XM_449854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIU0"/>
    <dbReference type="FunCoup" id="Q6FIU0">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIU0"/>
    <dbReference type="EnsemblFungi" id="CAGL0M11792g-T">
        <property type="protein sequence ID" value="CAGL0M11792g-T-p1"/>
        <property type="gene ID" value="CAGL0M11792g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891249"/>
    <dbReference type="KEGG" id="cgr:2891249"/>
    <dbReference type="CGD" id="CAL0137477">
        <property type="gene designation" value="CAGL0M11792g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11792g"/>
    <dbReference type="eggNOG" id="ENOG502QRIU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021324_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIU0"/>
    <dbReference type="OMA" id="WYKKPAV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026241">
        <property type="entry name" value="GIP4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02082">
        <property type="entry name" value="GLC7IP4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000292483" description="GLC7-interacting protein 4">
        <location>
            <begin position="1"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="647"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="897" mass="100471" checksum="1498D38687CC4B43" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIY1</accession>
    <name>Q6FIY1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pyridoxal kinase</fullName>
            <ecNumber evidence="2">2.7.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M10725g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyridoxine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.35" evidence="2"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIY1"/>
    <dbReference type="FunCoup" id="Q6FIY1">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIY1"/>
    <dbReference type="KEGG" id="cgr:2891378"/>
    <dbReference type="CGD" id="CAL0136733">
        <property type="gene designation" value="CAGL0M10725g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M10725g"/>
    <dbReference type="eggNOG" id="KOG2599">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046496_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FIY1"/>
    <dbReference type="OMA" id="FEMETLT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008478">
        <property type="term" value="F:pyridoxal kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009443">
        <property type="term" value="P:pyridoxal 5'-phosphate salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01173">
        <property type="entry name" value="pyridoxal_pyridoxamine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004625">
        <property type="entry name" value="PyrdxlKinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00687">
        <property type="entry name" value="pyridox_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534">
        <property type="entry name" value="PYRIDOXAL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10534:SF12">
        <property type="entry name" value="PYRIDOXAL KINASE BUD17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="7">
        <location>
            <begin position="104"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="323" mass="35768" checksum="C78254D840FA5CA2" modified="2004-07-19" version="1">MTGEGSVPGGVSVVGKVLAIQSHVVHGYVGNRAATFPLQYRGWDVDALNTVQYSNHLGYGQATGFKYSGEELCSVFRDGLLKAMGNRYDAIITGYTPSAEVLEDISGIIKNQLNQQQDLKWIVDPVLGDNGRLYVSEDIVPVYKRLLSQNKIFLATPNQFEMELLSESELTDLESASTAVSKFFQLYPHVERLVVTSVVLAGSDDYVVIAADRTTSPQDTIYIRSPRIKCHFSGSGDLFTALLVDALLRDRESTKLSQAVAKSQWMIGSVLQRTYEQALKSGELKDQDSPVIKDLKLIQCRELFRLHDIPEIPITGHINVPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ66</accession>
    <name>Q6FJ66_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAGL0M08800g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ66"/>
    <dbReference type="STRING" id="284593.Q6FJ66"/>
    <dbReference type="KEGG" id="cgr:2891289"/>
    <dbReference type="eggNOG" id="ENOG502SC5V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1057670_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ66"/>
    <dbReference type="OMA" id="ASQPAHY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="263" mass="29544" checksum="489BEDE20FC5A028" modified="2004-07-19" version="1">MGQVNMRPSLASQPAHYQLPSIAPNIHPHQYTTSQPPHQQHYHVVHTPISRISSENGQQQHMMPPSMNPTAYQGPEQVIIDHGIPTFQYAHQPQHVLRSSIMTGANMSPGQPQPQTIVMGPQPIQHAIDGHLASQTIATPMGTTLLTSSAQLQGQKTKKNTKRAMQNRKAQKAFRQRKEQYIKLLENEAKLIDDVMKKNQDLTSENEQLRDCLNRLIEKLKDNGIEVDIPSDFLDKINASISASRRLQEQHEEISKSIAGEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ76</accession>
    <name>Q6FJ76_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M08580g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ76"/>
    <dbReference type="KEGG" id="cgr:2891278"/>
    <dbReference type="CGD" id="CAL0136437">
        <property type="gene designation" value="CAGL0M08580g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08580g"/>
    <dbReference type="HOGENOM" id="CLU_1383987_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ76"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14372">
        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0136437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="197" mass="21839" checksum="DE0EA2475457203A" modified="2004-07-19" version="1">MSIDGYSYLQKYLVFADIKQLNTEVEQNVHYEKLVKAFPTVDKLIIRAILLAARGDLAPAFNALLSLTGEDIQLGLPMRRYEFLPDKTLMEQALRAKQEDMLEQLSQLQEPSSKAKSAGSETKEKSVPTGDGVSTEAMTGEAQSEPQMMENNAEDPKDITDKGLISDTKSEEANISVVEPQVENGKSVNPFELLQDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJD1</accession>
    <name>LPE10_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial inner membrane magnesium transporter LPE10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LPE10</name>
        <name type="ordered locus">CAGL0M07249g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms homooligomers. Interacts with MRS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJD1"/>
    <dbReference type="SMR" id="Q6FJD1"/>
    <dbReference type="FunCoup" id="Q6FJD1">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0M07249g-T">
        <property type="protein sequence ID" value="CAGL0M07249g-T-p1"/>
        <property type="gene ID" value="CAGL0M07249g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891712"/>
    <dbReference type="CGD" id="CAL0136217">
        <property type="gene designation" value="CAGL0M07249g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M07249g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07249g"/>
    <dbReference type="eggNOG" id="KOG2662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025144_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FJD1"/>
    <dbReference type="OMA" id="TRNNCII"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000043237" description="Mitochondrial inner membrane magnesium transporter LPE10">
        <location>
            <begin position="38"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="YGMN">
        <location>
            <begin position="340"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q02783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="397" mass="45159" checksum="06940662E0AE8098" modified="2004-07-19" version="1" precursor="true">MLLVNRAITLNLVKRCCWRSTMFMTPKRFLGTSEEESTAALLLQKNLIQRNNMLYGHGSGTIRCTVFDAGGNIVSPALDIKREELVAKHGLLPRDLRKIEKSRKNDLVPSFLVRKNGILVSLATIKTLIKPDMVIVFDSFGSLNSTSHKAFLNSLKLRLQNLDMVELKKDPLPYEFRALESIFISALSNLTSEMNVQVTICKGILQDLEYSITRDKLKFLLGQNKKLSNFYKKTVLIRDMLDDLLEQSDVLCSMYLSDLKNGVEHKDDDHSEIEMLLETYHNHLDEIVQITENIISNVKTTEEIINIILDSNRNQLMLLGIRFSIGMLSLGGPIFIGSLYGMNLENFIEETDYGFIAASAIGMISLGALYFYSIKHLHKLQKMSLFNYTNYARDVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJH6</accession>
    <name>Q6FJH6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">alcohol O-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alcohol O-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0M06237g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:17229"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:47622"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.84" evidence="8"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJH6"/>
    <dbReference type="FunCoup" id="Q6FJH6">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJH6"/>
    <dbReference type="ESTHER" id="canga-q6fjh6">
        <property type="family name" value="abh_upf0017"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891666"/>
    <dbReference type="CGD" id="CAL0137377">
        <property type="gene designation" value="CAGL0M06237g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06237g"/>
    <dbReference type="eggNOG" id="KOG1838">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032487_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FJH6"/>
    <dbReference type="OMA" id="HTMDIRE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004026">
        <property type="term" value="F:alcohol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000137">
        <property type="entry name" value="EEB1p Acyl-coenzymeA:ethanol O-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012020">
        <property type="entry name" value="ABHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF44">
        <property type="entry name" value="MEDIUM-CHAIN FATTY ACID ETHYL ESTER SYNTHASE_ESTERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005211">
        <property type="entry name" value="Ab_hydro_YheT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="11">
        <location>
            <begin position="165"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0137377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG62594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="453" mass="51630" checksum="C92AE050A63224CD" modified="2004-07-19" version="1">MSVNTWPLINPFNWGYNGTIKHVTHDEGTVKLQLKNGEEPLQFEEFLNKYVPELKNDAKFKLNPALFTGILQTMYLGSADYSREFQVFYGREIVKFSDGGVCTVDYVMKDWENEYKLNETTKKFDVEKFKQDEADTHAEGWPRLQPRTRYLRDNELQEVHSDDRPLVLVLHGLAGGSHEPVIRSLTQQLSRIGGGKFQVAVLNSRGCARSKITTRSLFTAFHTGDTREFLQRVRNHHPNKKIYAVGFSFGATMLANYLGEEGENTPLSAACTLSNPWDMVMSSVKTSNDWWSKNLFSANITQFLVRLVKVNMGELEVPEGTEPDHPPTVKNPSYYNFTKSNLQKAFKFKTIADFDSTYTAPCLGFKSAMDYYKSASSINRLPNIKIPLLSINARDDPVVGPEGVPFDLMKQNPHVVHCETDIGGHLAYLDLEWKPWVTKEIAQYFNVFDDHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJL4</accession>
    <name>Q6FJL4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M05379g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJL4"/>
    <dbReference type="FunCoup" id="Q6FJL4">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJL4"/>
    <dbReference type="KEGG" id="cgr:2891627"/>
    <dbReference type="CGD" id="CAL0136985">
        <property type="gene designation" value="CAGL0M05379g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05379g"/>
    <dbReference type="eggNOG" id="KOG0858">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1256224_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJL4"/>
    <dbReference type="OMA" id="FKKGQYE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070843">
        <property type="term" value="P:misfolded protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="212" mass="24915" checksum="84578F7E1B3D2F4F" modified="2004-07-19" version="1">MDAVLLNIVNDVPVVTRYWTMGCIAVSALVRFNMINSIKMLYSYEIVFQKGHYERILYSLFDYGLFNWMSLMNIVIAANHLSFLENSFSLKRRYVWILFLTLCSLLGMSYFGQPVASLGVLLQENLSYYYLKKNNEQMNIRLFGNIAVSPLLVPFYLNCLLLFVYHMDVVEVAMFFLPGHIMFYMDDMLKRIYGVDLTKTPYDWWLGLKETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJP2</accession>
    <name>Q6FJP2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M04697g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJP2"/>
    <dbReference type="FunCoup" id="Q6FJP2">
        <property type="interactions" value="629"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJP2"/>
    <dbReference type="KEGG" id="cgr:2891561"/>
    <dbReference type="CGD" id="CAL0137311">
        <property type="gene designation" value="CAGL0M04697g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04697g"/>
    <dbReference type="eggNOG" id="KOG1530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FJP2"/>
    <dbReference type="OMA" id="YEGSWTD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="51"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="153" mass="17372" checksum="65C71BE9CBEBF873" modified="2004-07-19" version="1">MFKRVVSISRGRVSPIRLVGLNRSANMIRYLSTNGPKAYNFEDIKQLVQHPDPKKVLVDVREPEELKECKLPNSINIPLKSAPGALGLPEEEFQELFHIEKPPKDKELIFFCALGVRAKTSEELARSYGYESTGVWEGSMKEWKEKGGDKIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJU9</accession>
    <name>Q6FJU9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M03399g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJU9"/>
    <dbReference type="FunCoup" id="Q6FJU9">
        <property type="interactions" value="909"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJU9"/>
    <dbReference type="KEGG" id="cgr:2891503"/>
    <dbReference type="CGD" id="CAL0136287">
        <property type="gene designation" value="CAGL0M03399g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03399g"/>
    <dbReference type="eggNOG" id="KOG0416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_7_1_1"/>
    <dbReference type="InParanoid" id="Q6FJU9"/>
    <dbReference type="OMA" id="KFYVRFK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000016">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="214" mass="24433" checksum="A7DB82A1199ACC77" modified="2004-07-19" version="1">MSGNSKRRIETDVMKLLMSDHEVELVEDSMQEFHVKFYGPKDTPYEGGVWRLHVELPDNYPYKSPSIGFVNKIFHPNIDIASGSICLDVINSTWSPLYDLLNIVEWMLPGLLKEPNGSDPLNNEAANLQLKDKKVYEEKVREYIDKYATKERYESQFGTPEDDEDDGDDAEMKDEDGDDDIDEPVSDLEDISDDNADPSEELSDISDIELSDED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJW2</accession>
    <name>EXO70_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EXO70</name>
        <name type="ordered locus">CAGL0M03113g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449482.1">
        <property type="nucleotide sequence ID" value="XM_449482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJW2"/>
    <dbReference type="SMR" id="Q6FJW2"/>
    <dbReference type="FunCoup" id="Q6FJW2">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJW2"/>
    <dbReference type="EnsemblFungi" id="CAGL0M03113g-T">
        <property type="protein sequence ID" value="CAGL0M03113g-T-p1"/>
        <property type="gene ID" value="CAGL0M03113g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891490"/>
    <dbReference type="KEGG" id="cgr:2891490"/>
    <dbReference type="CGD" id="CAL0136511">
        <property type="gene designation" value="CAGL0M03113g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M03113g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03113g"/>
    <dbReference type="eggNOG" id="KOG2344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010236_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FJW2"/>
    <dbReference type="OMA" id="GIIRAGP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001927">
        <property type="term" value="P:exocyst assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0268">Exocytosis</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000118967" description="Exocyst complex protein EXO70">
        <location>
            <begin position="1"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="623" mass="71155" checksum="A66E02D0846BB80E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-07-27" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK15</accession>
    <name>PFF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar membrane protease</fullName>
            <ecNumber evidence="6">3.4.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FXNA-related family protease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">CAGL0M01936g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK15"/>
    <dbReference type="SMR" id="Q6FK15"/>
    <dbReference type="FunCoup" id="Q6FK15">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK15"/>
    <dbReference type="MEROPS" id="M28.A05"/>
    <dbReference type="EnsemblFungi" id="CAGL0M01936g-T">
        <property type="protein sequence ID" value="CAGL0M01936g-T-p1"/>
        <property type="gene ID" value="CAGL0M01936g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891755"/>
    <dbReference type="CGD" id="CAL0136615">
        <property type="gene designation" value="CAGL0M01936g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01936g"/>
    <dbReference type="eggNOG" id="KOG2194">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006412_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FK15"/>
    <dbReference type="OMA" id="TPWPVTI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
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    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0862">Zinc</keyword>
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            <begin position="1"/>
            <end position="947"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
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            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="37"/>
            <end position="358"/>
        </location>
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            <begin position="359"/>
            <end position="379"/>
        </location>
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            <begin position="380"/>
            <end position="391"/>
        </location>
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        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="413"/>
            <end position="428"/>
        </location>
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        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="450"/>
            <end position="458"/>
        </location>
    </feature>
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        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
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            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="3">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="511"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=7" evidence="3">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="1">
        <location>
            <begin position="623"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=8" evidence="3">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="663"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=9" evidence="3">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
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        <location>
            <begin position="691"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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            <note>catalytic</note>
        </ligand>
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        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
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    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
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    <feature type="binding site" evidence="2">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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            <note>catalytic</note>
        </ligand>
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        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
    </feature>
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            <position position="299"/>
        </location>
    </feature>
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        <location>
            <position position="46"/>
        </location>
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        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="4">
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        <location>
            <position position="801"/>
        </location>
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        <location>
            <position position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38244"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="UniProtKB" id="P80561"/>
        </source>
    </evidence>
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    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="947" mass="107339" checksum="40D31ECDB228E936" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK80</accession>
    <name>Q6FK80_CANGA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M00440g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0137207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="232" mass="26950" checksum="3E1DAD4B55320831" modified="2004-07-19" version="1">MTNKSEIIDEYTAVLEREIENKRYFLKESHDALRDLIESKAERLNGAGSVQGRRSAINKDVWQKFMEKPMYLPERQDPIGLNLVSARLREKTESMGPWLEVEKEIVHVEETYLNSLRQLNAAMQDTIAEFRKNPPKPREELVSKDYSLSSLKTQHESLHKELKEFVTRYLEPNAPENTSAEEMLQLISTLVQGKTLDKDQFKNSQSLFRLLMKGMLLENTDTNSYKLIDLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKC1</accession>
    <name>Q6FKC1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1-gamma 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0L12760g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKC1"/>
    <dbReference type="FunCoup" id="Q6FKC1">
        <property type="interactions" value="992"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKC1"/>
    <dbReference type="KEGG" id="cgr:2890609"/>
    <dbReference type="CGD" id="CAL0135876">
        <property type="gene designation" value="CAGL0L12760g"/>
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    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_3_0_1"/>
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        <property type="entry name" value="Elongation factor 1 gamma"/>
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    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
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        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="86"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="6">
        <location>
            <begin position="247"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0135876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="47230" checksum="6849A577EB2C2606" modified="2004-07-19" version="1">MSQGALYANARVRTMVPRALIRHLKLDIDILDPAQEEERFARDFPWKKVPAFAGKNFKLTEAMAINYYLINLSSDEKFKQQMLGATLEEQAQVIRWESLANSDLIMQMAEAFFPLIGNVPYNKRVVDAALVKVEQIVSLFEERLTHYTFLASENLSLADLVCCAIFTRGFDYLFGKQWRAEHPAIVRWFNHVRSTDIMKEEYKDFKFIDKQVEPPKTESKKPKKAEKKADKPAEKPAAEAPQQEKKPKHPLEALGRSTFVLDEWKRKYSNEDTRPVALPWFWEHYNPEEYSLWKVGYKYNDELTMTFMSNNLVGGFFNRLSASTKYMFGCLVVYGENNNNGIVGAVMVRGQDHVPAFDVAPDWESYEYTKLDPTKEEDKEFVNNMWAWDKPVVVNGESKEIADGKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKL9</accession>
    <name>Q6FKL9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0L10538g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKL9"/>
    <dbReference type="FunCoup" id="Q6FKL9">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKL9"/>
    <dbReference type="KEGG" id="cgr:2891036"/>
    <dbReference type="CGD" id="CAL0135392">
        <property type="gene designation" value="CAGL0L10538g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10538g"/>
    <dbReference type="eggNOG" id="ENOG502QPT5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_10_2_1"/>
    <dbReference type="InParanoid" id="Q6FKL9"/>
    <dbReference type="OMA" id="GMIDEVN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000047">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="10">
        <location>
            <begin position="9"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="11">
        <location>
            <begin position="218"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0135392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG62199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="377" mass="42610" checksum="9B80FB817E8DBE8E" modified="2004-07-19" version="1">MTAAVRPVVHIVGLGAVGTVLAVDLLRFTNVSLVPLFRSQAKLDYFRNDCKSTFGIRKLYEENTPVYKYKIENSECPTTFPGGKISNLIVTTKTYQTKEAISPYLPYIDSNTNIILIQNGLGVLEVLRDDIFKNSSQRPHLFQGVISHGIFQDEGFIYNHAGWVGMKIARLPWTDNEMIQTSQSVQNDEQNELIGLLTQKILAKEFGIEHMSYQELLLGQLHKFLVNACMNPVTAIVDCVNGEMIDDCPPVFKSIVDECLDVLRVAYKPLFDYEETYKGKTEYPSLSVNDTLEPKQLVKDIIRVGCDLNAKNSTSMRQDTLYLRETEINYINGYIVQLAQTHNLGPNACKVNKTITELVNLRSGLNKTRAEKGDWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKW3</accession>
    <name>Q6FKW3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-binding protein SNT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0L08162g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKW3"/>
    <dbReference type="KEGG" id="cgr:2890558"/>
    <dbReference type="CGD" id="CAL0135486">
        <property type="gene designation" value="CAGL0L08162g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08162g"/>
    <dbReference type="eggNOG" id="KOG1878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004864_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKW3"/>
    <dbReference type="OMA" id="LFCEGFC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Set3C deacetylase complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="735"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="983"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="799"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1144"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="799"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1187"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0135486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1356" mass="152846" checksum="214192BABDA7523F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKX1</accession>
    <name>Q6FKX1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ectonucleotide pyrophosphatase/phosphodiesterase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L07986g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKX1"/>
    <dbReference type="KEGG" id="cgr:2891014"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07986g"/>
    <dbReference type="eggNOG" id="KOG2645">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017594_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FKX1"/>
    <dbReference type="OMA" id="SEPIWET"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
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    </dbReference>
    <dbReference type="GO" id="GO:0009141">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="74974" checksum="E52EB94D1B7451C3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2025-06-18" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL15</accession>
    <name>EIF3I_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="1">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="1">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TIF34</name>
        <name type="ordered locus">CAGL0L06952g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449079.1">
        <property type="nucleotide sequence ID" value="XM_449079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL15"/>
    <dbReference type="SMR" id="Q6FL15"/>
    <dbReference type="FunCoup" id="Q6FL15">
        <property type="interactions" value="1182"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL15"/>
    <dbReference type="EnsemblFungi" id="CAGL0L06952g-T">
        <property type="protein sequence ID" value="CAGL0L06952g-T-p1"/>
        <property type="gene ID" value="CAGL0L06952g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890824"/>
    <dbReference type="KEGG" id="cgr:2890824"/>
    <dbReference type="CGD" id="CAL0135416">
        <property type="gene designation" value="TIF34"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L06952g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06952g"/>
    <dbReference type="eggNOG" id="KOG0643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043845_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FL15"/>
    <dbReference type="OMA" id="VWFSHNG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000365362" description="Eukaryotic translation initiation factor 3 subunit I">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="291"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <sequence length="347" mass="38661" checksum="161037C39BDACFA6" modified="2004-07-19" version="1">MRPIVLMGHERPLTQVKYNREGDLLFTCSKDISASVWYSNNGERLGTLDGHMGSIWSIDSDHTSLYCVTGSADYTIKVWTLMNGQCVQTWNCPVPVKRVEFSPCGKYILAILDNVMKKPGSIEIYEVKRNPETNEITEFVEEPIHSIVTHEGLDAASVAGWSGEGKYIIAGHKDGKISKYDTQDGYKLVESQQVHKDSVSDLQFSPDRTYFITCSRDSNAHIIDIETFKVLKTYETDSPLNSAAITPLKEFVILGGGQDASEVTTTSASEGKFEARIYHKVFEEEIGRVVGHFGPLNSIAVSPQGTSYTSGGEEGLVRLHHFEKSYFDFKYDVEKAADAKEHISHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL76</accession>
    <name>Q6FL76_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0L05588g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL76"/>
    <dbReference type="FunCoup" id="Q6FL76">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL76"/>
    <dbReference type="KEGG" id="cgr:2890797"/>
    <dbReference type="CGD" id="CAL0135802">
        <property type="gene designation" value="CAGL0L05588g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05588g"/>
    <dbReference type="eggNOG" id="KOG0807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FL76"/>
    <dbReference type="OMA" id="KRESWGH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110050">
        <property type="term" value="F:deaminated glutathione amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000024">
        <property type="entry name" value="Deaminated glutathione amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0135802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="313" mass="34990" checksum="3124C7CD46599AAE" modified="2004-07-19" version="1">MSVKIAIGQLCSSSQHAQNLSIVASLIERAIKLDARVIFFPEATDYLSQNATHSRVLAKSSPTFVDDLQLKIKDINERYKSEKRAIDVSIGVHLPPSEQDILKGDDRVKNVLLYIDSSGVIRSSYTKLHLFDVDVPNGPILKESQSVQPGDQIPSIIDTPAGKLGCSICYDIRFPELALRLRSMGAQILCYPSAFTMKTGQAHWELLGRARAIDTQCYVVMPGQSGTHNVTEDTWSKTADSKTNPNSVTRMSWGHSMIINPWGDVIARSDETNNEPQLVVSDIDLKSMERVRVNMPLWQQRRLDLFDNNYSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLW6</accession>
    <name>Q6FLW6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L-type lectin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0K12914g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLW6"/>
    <dbReference type="STRING" id="284593.Q6FLW6"/>
    <dbReference type="KEGG" id="cgr:2890122"/>
    <dbReference type="CGD" id="CAL0134303">
        <property type="gene designation" value="CAGL0K12914g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12914g"/>
    <dbReference type="eggNOG" id="ENOG502QR1C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050572_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLW6"/>
    <dbReference type="OMA" id="MTIEWTF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06903">
        <property type="entry name" value="lectin_EMP46_EMP47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016710">
        <property type="entry name" value="Emp46/Emp47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035661">
        <property type="entry name" value="EMP46/EMP47_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018136">
        <property type="entry name" value="L-type_lectin_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273446" description="L-type lectin-like domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="9">
        <location>
            <begin position="26"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018136-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0134303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="428" mass="48851" checksum="3FE80464FF60A638" modified="2004-07-19" version="1">MFCLQLLYLYILITGVYGHVINKSGDETTLRRDISLLDLVKASKLPAQWNALESARLVEGRVVLTPKTNTKGSIWLQDPFPIKDAFTVEWTFRSINFSGKSKGGMSFWVLDDTTQLDDKLYGGPNKFSGLQILIDNFSNYGPSVRGILNDGSQEFKQEDIYSNAFASCLMGYQDSAVPFTMRLSYSPKENHLLKLQIDNQVCFQTRNILLPQKNFRIGTSANNAGTEESFELLRIKLYDDILEKALEPNMKAMPQPKTVQKIINKDTGAQTMKEKDIFDTKKSDVSVLDIYKKIDQLEGKIIGNDVSTLLTSVDNAIEGQRKMNKHLDELLTQLKLFAHFENKDLLTKDDTIIPDNYKEFLNMNDKLGELLKEQESIRMEHRKNHGEITSTDVLNKLFLWMLPLIGVILLTAYHTYKIQQEISKTKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMX6</accession>
    <name>Q6FMX6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K04433g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMX6"/>
    <dbReference type="FunCoup" id="Q6FMX6">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMX6"/>
    <dbReference type="KEGG" id="cgr:2889997"/>
    <dbReference type="CGD" id="CAL0134139">
        <property type="gene designation" value="CAGL0K04433g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04433g"/>
    <dbReference type="eggNOG" id="KOG0037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_863808_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMX6"/>
    <dbReference type="OMA" id="FTNSNAM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007120">
        <property type="term" value="P:axial cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007121">
        <property type="term" value="P:bipolar cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="321"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="361" mass="40856" checksum="D7FE69978847082E" modified="2004-07-19" version="1">MCARKLKYAAGDDLLLYATPKEAMQNTKRNEEDKKPRVRKPNVRTPSEPGMGQPMPTGRSSGDYVHGASYVPKHQSLSQPQLQQMPIPNAYSSSKTRPIPQQMIGNPVQNLRGNNYGGQGRIVSSPPAMVPPSAAMQRAQAQVSHTPPRIANKSPEVAQNAMLSRTKGALRDSSQTLSEEDAKDTRIAIQLFHNHDVRGKERLTAEELQNLLQNDDNTHFCISAVDALINLFGATRFGTVNESEFISLYKRVKKWRKIYVDNDINGSYTITMSEFHNSLQELGYMVPVEVSEKLFDQYAEFINPANNAKELKFDKFVEALVWLMRLTKLFRKFDKNQDGVAHIQYKEFIDVTLYLGRFLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMY8</accession>
    <name>Q6FMY8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KSS1</name>
        <name evidence="10 11" type="ordered locus">CAGL0K04169g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448406.1">
        <property type="nucleotide sequence ID" value="XM_448406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMY8"/>
    <dbReference type="FunCoup" id="Q6FMY8">
        <property type="interactions" value="792"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMY8"/>
    <dbReference type="GeneID" id="2890046"/>
    <dbReference type="KEGG" id="cgr:2890046"/>
    <dbReference type="CGD" id="CAL0134719">
        <property type="gene designation" value="KSS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04169g"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q6FMY8"/>
    <dbReference type="OMA" id="CYFLYQM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010973">
        <property type="term" value="P:positive regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034756">
        <property type="term" value="P:regulation of iron ion transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="13"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0134719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="398" mass="45746" checksum="B6116D29911A0F96" modified="2004-07-19" version="1">MPRTITFNIPKEYKLVDLVGEGSYGIVCSATHLPTGNKVAIKRIRFPDSPPSDDGQGVPRLEEDDEHDNIAKVALIRTIREIKILSHFNNHENIITIFEKIKPMQSINFKEIYLVQELMETDLSRILASSNTLTVDHIQYFLYQILRALKAIHSAKVIHRDLKPSNILLNSNCDLKICDFGLARTYDPDDDASTMNGNNVGFLTEYVATRWYRAPEIMLNFQDYSTAIDIWSCGCVLAEMLFRKPIFPGKDYHHQLLLILDTLGTPSPEDIEAINYGRAKEYILSLPHFPKKDWSQLLGTDNEMLLDILDKLMIFNPKRRITAEQALEHPFLATYHDPKDEPNFPPLNFKGDEFWQLDNCMETSNGYGTDDSNNLRANVTRRKLREILYQEMVTPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN27</accession>
    <name>Q6FN27_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcriptional repressor OPI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">OPI1</name>
        <name evidence="2 3" type="ordered locus">CAGL0K03267g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448367.1">
        <property type="nucleotide sequence ID" value="XM_448367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN27"/>
    <dbReference type="FunCoup" id="Q6FN27">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN27"/>
    <dbReference type="GeneID" id="2890167"/>
    <dbReference type="KEGG" id="cgr:2890167"/>
    <dbReference type="CGD" id="CAL0134275">
        <property type="gene designation" value="OPI1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03267g"/>
    <dbReference type="eggNOG" id="ENOG502RG16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039546_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN27"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071072">
        <property type="term" value="P:negative regulation of phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54838" checksum="DD028912E7C5E8B8" modified="2004-07-19" version="1">MDTRRGWIHNYISFSGLSEEDVEAAEALDVLRNSHVDADVEVEEDRSKKRVRDGEDEDGGHVRRRKASVRDRSDSRMSQLSNVSNASTEERVVRVNSHEDSQSKRQEEESLFDKVCRNSNEILTNMGSFFEEMNSNVFMEGGSDVPEEHPNGYVRPRRDSRSISTTGADADTESQGTQGSYNGKWDTWSSRSYNDRQYYSKRKALSEALAKGRYNLREYKLTMSIESKKRLITCLHLLKLANKQLSDKVAYLQDAVEKEQELANGEEVKKETRALNGEHSGPQNDDDLEFYDASESVDQNSGDLGLEIVGTVKKVYSLISKYTGSSLPEPARSQVRESLLNLPSNWNTSVHNGFKNNGTGIMTASSSTDSLSSYSSILPVSSNGKYLILAKESLNMVQSVIDVVDSTLGRAEEWVKQKQELKEMIKKKFLEQQEHQKMLGIGTESLDQNESSVKKEQPTTHISISSITNSTNTLDTVKEEDMHLQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNA7</accession>
    <name>Q6FNA7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0K01441g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNA7"/>
    <dbReference type="FunCoup" id="Q6FNA7">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNA7"/>
    <dbReference type="KEGG" id="cgr:2890057"/>
    <dbReference type="CGD" id="CAL0134129">
        <property type="gene designation" value="CAGL0K01441g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01441g"/>
    <dbReference type="eggNOG" id="KOG0227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087074_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNA7"/>
    <dbReference type="OMA" id="PFIRIVS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="10">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0134129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="263" mass="30266" checksum="B596E47AE43C7290" modified="2004-07-19" version="1">MDFQNRAGSKKGGGGIASDSQINQQRRRQVEELLQQGENIKYTFQDKEGEKDDTDTKKVQSNPYIYKNHSGKLVCKLCNTMHMSWSSVERHLGGKKHGMNVIRRGELDEIRHEKQQATKPVDTFEMKVEARRKTINTIEGLVPTCHSTEVIDEKGNKGIAVMLEFEESDKTADVLNADRPYARIVSGLELNTSAQKDKRFLVVAYEPYQNVAIEIPNDREIVMNGYQPQSDEEIFVDTLNRQCTFWIENQRQFIVQIFFKETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNG6</accession>
    <name>Q6FNG6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22" type="ordered locus">CAGL0J11836g</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNG6"/>
    <dbReference type="FunCoup" id="Q6FNG6">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNG6"/>
    <dbReference type="KEGG" id="cgr:2889468"/>
    <dbReference type="CGD" id="CAL0133140">
        <property type="gene designation" value="CAGL0J11836g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11836g"/>
    <dbReference type="eggNOG" id="KOG3717">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FNG6"/>
    <dbReference type="OMA" id="KMDGTPT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="58"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0133140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG61179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="661" mass="76323" checksum="CBFA90DA15946E68" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNJ5</accession>
    <name>Q6FNJ5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">54S ribosomal protein L22, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0J11198g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNJ5"/>
    <dbReference type="FunCoup" id="Q6FNJ5">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNJ5"/>
    <dbReference type="KEGG" id="cgr:2889489"/>
    <dbReference type="CGD" id="CAL0133574">
        <property type="gene designation" value="CAGL0J11198g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11198g"/>
    <dbReference type="eggNOG" id="KOG1711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081667_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNJ5"/>
    <dbReference type="OMA" id="WVQLADK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000022">
        <property type="entry name" value="Mitochondrial ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0133574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG61150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35539" checksum="799D338560D45A16" modified="2004-07-19" version="1">MFSRSLMRNAGLPLRNASRVLANRRLLSTSFPCLNNSGNLFGSITDTGNTNLEDKYDPTRETSRLEAAVKSTDDSGEISVDKDSITFEKDEVLQNYIREQFQKEALAPELLLSPLKRQVYELNCKQNGGFYKEDTVVTIPETKEKYKLKLSRQELEALEPSIYLRSYRLKYSTKKAIHLLRMLSGLDVKKAITQCHFSDKKIARDLAELFQKGIEDGKKLGLDADDLYISQIWSGNDGYLQKRVEYKGRGRIGIIRHRHIHVRCILKTHSVTKKRLEYEKQLKEQNKKPWVQLADRPIRGVPGNAYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNP1</accession>
    <name>Q6FNP1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import receptor subunit TOM7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0J10179g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNP1"/>
    <dbReference type="FunCoup" id="Q6FNP1">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNP1"/>
    <dbReference type="KEGG" id="cgr:2889444"/>
    <dbReference type="CGD" id="CAL0133164">
        <property type="gene designation" value="CAGL0J10179g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10179g"/>
    <dbReference type="eggNOG" id="KOG4449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173610_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FNP1"/>
    <dbReference type="OMA" id="FILYLGW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012621">
        <property type="entry name" value="Tom7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34944:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08038">
        <property type="entry name" value="Tom7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0133164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6952" checksum="4E50D1A82CE5EF44" modified="2004-07-19" version="1">MNFLPSFILSDESKERFNKILDLTQRVAHYGWIPFVLYLGWAQTANKPNLFNLLSPLPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNQ0</accession>
    <name>Q6FNQ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial N(5)-glutamine methyltransferase MTQ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J09988g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNQ0"/>
    <dbReference type="FunCoup" id="Q6FNQ0">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNQ0"/>
    <dbReference type="KEGG" id="cgr:2889429"/>
    <dbReference type="CGD" id="CAL0133422">
        <property type="gene designation" value="CAGL0J09988g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09988g"/>
    <dbReference type="eggNOG" id="KOG2904">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FNQ0"/>
    <dbReference type="OMA" id="MPRIPYS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006451">
        <property type="term" value="P:translational readthrough"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0133422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37600" checksum="0423D2D6CA8CCE7C" modified="2004-07-19" version="1">MRIRPCDMRAAWGRHRWLPLLLPQCRSVDQALVEFGWMQGLAPDNIVQGNAVQGNAVQGNIVQGNAVPGNTAARRLLRGCAARFRGVPLQYVLGSQPFGAAELVCRPGVLIPRWETEEWALKLARAIARYSSQQPLAQPLKLTLVDLCTGTGCVPIGIHDELARAPSLIKYTAVDVSPQAIDLCRLNVGRRAIEVKQVDVLRQDSPADIVGGLGPGRGLGLGRGPAIDILLCNPPYIPRKAFTRTTARSVRLYEPRLALIADKEFYKNLVDVWSQHTNSFVYEIGDSSQYEYVKQALDPSVWSVGLHIDSNGCPRAVYGYRNSIPSIAYIFEEFKQPRYV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP42</accession>
    <name>RNY1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Ribonuclease T2-like</fullName>
            <shortName>RNase T2-like</shortName>
            <ecNumber>4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RNY1</name>
        <name type="ordered locus">CAGL0J06820g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68052"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="Rhea" id="RHEA-COMP:17355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:173118"/>
            <dbReference type="EC" id="4.6.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Vacuole lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Is released from the vacuole to the cytoplasm during stress conditions like oxidative stress or stationary phase stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448002.1">
        <property type="nucleotide sequence ID" value="XM_448002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP42"/>
    <dbReference type="SMR" id="Q6FP42"/>
    <dbReference type="FunCoup" id="Q6FP42">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP42"/>
    <dbReference type="GlyCosmos" id="Q6FP42">
        <property type="glycosylation" value="4 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0J06820g-T">
        <property type="protein sequence ID" value="CAGL0J06820g-T-p1"/>
        <property type="gene ID" value="CAGL0J06820g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889620"/>
    <dbReference type="KEGG" id="cgr:2889620"/>
    <dbReference type="CGD" id="CAL0133378">
        <property type="gene designation" value="CAGL0J06820g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06820g"/>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037966_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FP42"/>
    <dbReference type="OMA" id="HESLWIH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000043253" description="Ribonuclease T2-like">
        <location>
            <begin status="unknown"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="46"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="103"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="247"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="433" mass="49674" checksum="0D9C24B324520463" modified="2004-07-19" version="1" precursor="true">MILASVLKAFQGLQTGLQHSYQDGSPSCPINLPLSCGNETAISDLCCFEYPGGILLMTQFWNYAPSKPNLNRTELEEELGPVDSFTIHGLWPDDCMGGYPQFCKRDLFIDDVDYLLKSDAFNNDDTLPIQGEELLNNLNKYWKSNNGNHESLWIHEYNKHGTCLSTLQPQCYSRWNPTTSQKGPKYYKKKAVYDYFRISYDLFQKLNTYEMLAKHNITPSNDTSYTKSEILSALSSEFQGTQAHINCNSQNALTEVWYYHQLNGSILNEDFIPLDPLRSMSRCKDQGIKYYPKGYQRRDNRGPNKKPISRGTIRISQYGGFLIKTGRWMKRGTPANFELIESKYGNYLLKSRMGYCTVHNDKSQLDCSSRSPDYATQFDYNEEKGILGYSGSFEWGAESAPKNGRTSRSVVFAVSNEKNSNLKYKFQLKFNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP83</accession>
    <name>Q6FP83_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ASI2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0J05874g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP83"/>
    <dbReference type="FunCoup" id="Q6FP83">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889770"/>
    <dbReference type="CGD" id="CAL0133652">
        <property type="gene designation" value="CAGL0J05874g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05874g"/>
    <dbReference type="eggNOG" id="ENOG502RZCQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074623_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP83"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="36480" checksum="AC5F0990825D9D14" modified="2004-07-19" version="1">MNDQEGDSDSELYEQYLEDRRRLQSREDAHEIQTSEEVLQRNLDETLSRVLRNWSQEIDNHHVRIRITGRRHENTNSNSHTNNSYNNGAATENRNNNYGNMLGINLPSHNSIGSNSNGVNQRTPFAQRPSFFRTLVRNLLVLNYLVLSLLFPFSLYNVLRSGFSTMTFSERDFTREILTYWYAIDTVDVISLIKPSTPETSDSGPGLGLLGKFHNIIVYYSLPIGEALLRRILNIDRSYTDTEEYPVSVGIYRMILGFFFRWYKKSIKIVTILVYLLYGIGGTTYLMIAGFFFSLCVGLTIVRRYKSTQQILSGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP87</accession>
    <name>Q6FP87_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">B box-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J05786g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447957.1">
        <property type="nucleotide sequence ID" value="XM_447957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP87"/>
    <dbReference type="STRING" id="284593.Q6FP87"/>
    <dbReference type="KEGG" id="cgr:2889806"/>
    <dbReference type="CGD" id="CAL0133028">
        <property type="gene designation" value="CAGL0J05786g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05786g"/>
    <dbReference type="eggNOG" id="ENOG502QRJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021807_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP87"/>
    <dbReference type="OMA" id="DAFAHMF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018553">
        <property type="entry name" value="E2_Ub-conjug_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057668">
        <property type="entry name" value="E2_Ub-conjug_enz_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560">
        <property type="entry name" value="UPF0652 PROTEIN C16A11.03C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560:SF0">
        <property type="entry name" value="UPF0652 PROTEIN C22H10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09418">
        <property type="entry name" value="DUF2009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0133028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="614" mass="70910" checksum="ABECA8D48379A257" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP97</accession>
    <name>Q6FP97_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein MKT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J05566g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP97"/>
    <dbReference type="FunCoup" id="Q6FP97">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP97"/>
    <dbReference type="KEGG" id="cgr:2889797"/>
    <dbReference type="CGD" id="CAL0133668">
        <property type="gene designation" value="CAGL0J05566g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05566g"/>
    <dbReference type="eggNOG" id="ENOG502QVHA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_378548_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP97"/>
    <dbReference type="OMA" id="RFYQTKV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="184"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0133668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="92086" checksum="91AF0676739D932D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPE2</accession>
    <name>Q6FPE2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division control protein 73 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0J04510g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPE2"/>
    <dbReference type="FunCoup" id="Q6FPE2">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPE2"/>
    <dbReference type="KEGG" id="cgr:2889640"/>
    <dbReference type="CGD" id="CAL0132940">
        <property type="gene designation" value="CAGL0J04510g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04510g"/>
    <dbReference type="eggNOG" id="KOG3786">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025849_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FPE2"/>
    <dbReference type="OMA" id="GYYFHFA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001209">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090262">
        <property type="term" value="P:regulation of transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="211"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0132940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="370" mass="42357" checksum="762AEF2C88B7CE35" modified="2004-07-19" version="1">MSVLVQLKKQLSSASEFTLVDGTGSTTADITNAEFIQFKEDKLPLDEATEFIVDEQPAKLRVIIQCWLHKDDSAAEYLADCQEKKITNISFLQRNDLLKWLSGESETSEYLDVKNIKTDNSEADVNTKTDVSESQKIIDDPVLQEATQKERILIDHNSMLHGSKPVDFGYLIKDAELKLVHSIKATLRSKQGSGKPGAVSKHGSQNQKTQKKDPIILIPSAASSLFAISNIKQFLESSQYINPRDATANTGSDVITVEKKFDRISRPIKFIVVNNTRMFTKPEYWDRVVAVFTTGHTWQFNNYQWNTPQELFQHCKGYYFHFTGDSVPQNVQQWNVDKVELDKTKRFKDVEVVRYFWNTIEKELMARGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPI0</accession>
    <name>Q6FPI0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0J03674g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPI0"/>
    <dbReference type="FunCoup" id="Q6FPI0">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPI0"/>
    <dbReference type="KEGG" id="cgr:2889684"/>
    <dbReference type="CGD" id="CAL0133018">
        <property type="gene designation" value="CAGL0J03674g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03674g"/>
    <dbReference type="eggNOG" id="KOG0831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023995_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FPI0"/>
    <dbReference type="OMA" id="RSQWMRR"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035356">
        <property type="term" value="P:intracellular triglyceride homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0133018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG60813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="434" mass="49908" checksum="7ACEC6FBE3E4B3DC" modified="2004-07-19" version="1">MFGNAFHLRNRIHKRSSSSDRLDQDESSDDGDNAPNIVEQKTKDIKLVKPLKRPRLSNCCSPTTPMANRLQTMAVAWHISSFVLFSIFSLLIISNPFTWIVVIPYLIYFFNDRSPANGDVVYRYSPWVRSLKIWKYYCDYFPIELVKTVDLEPTFTPCNEEEEKENKKLQEYYTLRLWPSDYEIRLFKKNTVYSHGYKRTGPKYIFGYHPHGIGALGSFGAFATEGRGWSNKFPGIPVSLLTLVTQFHIPFYRDYLLSVGISSVSRKNALKVLDNNQSICIVVGGARESLISIPGTSGLILNKRKGFIKLAIQAGNVSLVPVYTFGENDCYNILATDETSIIRKLQLWVKENFGFTIPIFYARGLFNYDFGLLPFRAPLHVVVGRPIHVKEQQENPEQSLVDHYHELYVEELKRIYLENRDRYGYGAADFEILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPL1</accession>
    <name>Q6FPL1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-ketoacyl-[acyl-carrier-protein] synthase I</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0J02970g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPL1"/>
    <dbReference type="FunCoup" id="Q6FPL1">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPL1"/>
    <dbReference type="KEGG" id="cgr:2889743"/>
    <dbReference type="CGD" id="CAL0133506">
        <property type="gene designation" value="CAGL0J02970g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02970g"/>
    <dbReference type="eggNOG" id="KOG1394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_1"/>
    <dbReference type="InParanoid" id="Q6FPL1"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="6">
        <location>
            <begin position="2"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0133506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="448" mass="48515" checksum="77DCCE01BDA9550C" modified="2004-07-19" version="1">MSRRVVVTGLGCVTPLGKSVKESWHRLLQRDSNGLVKLDQLTKGDFAKWRGIFPPELRVGAVSPIESFEVNSQLFTSQDDRRMSRFIKLATIASYEALVSSGLVNKETKMSEDGRIPIDQHNQGIDPDKVGCLIGSGIGSIEDIYETSVTFDSNTKKNRINPYFVPRILTNMAAGNIAIKFNLRGPTHSVSTACATGNNAIGDGYNMIKLGMQDICLAGASEASVHPLSLAGFLRAKSLSPDGISRPFDEERNGFVLGEGAGIVVLESLESAERRGAPILAEIVGYGLSCDAHHITSPPNDGEGASRAIKMALDLSHGNVNARDIEYVNAHATSTKLGDNTECCAIQNTLIDNVNRQKPLYISSNKGSIGHLLGAAGAAESIFTILSLYNRTIPHTYNLKNVLGNFESSSMRFVKSQPHKVADLEYALCNSFGFGGVNTSLLFRRWHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPL2</accession>
    <name>Q6FPL2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FCY2</name>
        <name evidence="10 11" type="ordered locus">CAGL0J02948g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447832.1">
        <property type="nucleotide sequence ID" value="XM_447832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPL2"/>
    <dbReference type="STRING" id="284593.Q6FPL2"/>
    <dbReference type="GeneID" id="2889742"/>
    <dbReference type="KEGG" id="cgr:2889742"/>
    <dbReference type="CGD" id="CAL0133722">
        <property type="gene designation" value="FCY2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02948g"/>
    <dbReference type="eggNOG" id="ENOG502QQ8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FPL2"/>
    <dbReference type="OMA" id="TIACVGW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015856">
        <property type="term" value="P:cytosine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11484">
        <property type="entry name" value="SLC-NCS1sbd_CobB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0133722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="515" mass="56330" checksum="038A60CC559F44A6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPL3</accession>
    <name>Q6FPL3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein PET117, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PET117</name>
        <name evidence="6 7" type="ordered locus">CAGL0J02926g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447831.1">
        <property type="nucleotide sequence ID" value="XM_447831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPL3"/>
    <dbReference type="FunCoup" id="Q6FPL3">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPL3"/>
    <dbReference type="GeneID" id="2889741"/>
    <dbReference type="KEGG" id="cgr:2889741"/>
    <dbReference type="CGD" id="CAL0133278">
        <property type="gene designation" value="PET117"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02926g"/>
    <dbReference type="eggNOG" id="ENOG502S49F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161486_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPL3"/>
    <dbReference type="OMA" id="VHYVQEL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0133278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14063" checksum="DD52610CAFCA5FFB" modified="2004-07-19" version="1">MINEPGGEVIKAGGREGVTAILASIYNQDQTMSRASKITFGVSCAVTLATIIGVHYVQELERETLHQGPIKDAKRVAEKKKLMPAGTDEKKLLNRSEHELQQELRKKYESMQPLSGEVVTQDGERVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPQ3</accession>
    <name>MPH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase MPH1</fullName>
            <ecNumber evidence="1">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA 3'-5' helicase MPH1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">FANCM-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MPH1</name>
        <name type="ordered locus">CAGL0J01980g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="1"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447791.1">
        <property type="nucleotide sequence ID" value="XM_447791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPQ3"/>
    <dbReference type="SMR" id="Q6FPQ3"/>
    <dbReference type="FunCoup" id="Q6FPQ3">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPQ3"/>
    <dbReference type="EnsemblFungi" id="CAGL0J01980g-T">
        <property type="protein sequence ID" value="CAGL0J01980g-T-p1"/>
        <property type="gene ID" value="CAGL0J01980g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889816"/>
    <dbReference type="KEGG" id="cgr:2889816"/>
    <dbReference type="CGD" id="CAL0133376">
        <property type="gene designation" value="CAGL0J01980g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01980g"/>
    <dbReference type="eggNOG" id="KOG0354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002513_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FPQ3"/>
    <dbReference type="OMA" id="EGIKWRN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033677">
        <property type="term" value="F:DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060543">
        <property type="term" value="P:negative regulation of strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18033">
        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12091">
        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000861">
        <property type="entry name" value="Fanconi anemia, complementation group M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039686">
        <property type="entry name" value="FANCM/Mph1-like_ID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044749">
        <property type="entry name" value="FANCM_DEXDc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025">
        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000333371" description="ATP-dependent DNA helicase MPH1">
        <location>
            <begin position="1"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="89"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="432"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="798"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="869"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1002"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAH box" evidence="3">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="875"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1005"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1029"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P40562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9UT23"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1052" mass="120576" checksum="9A3496875A22095A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPS9</accession>
    <name>Q6FPS9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centromere DNA-binding protein complex CBF3 subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CTF13</name>
        <name evidence="1 2" type="ordered locus">CAGL0J01243g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447765.1">
        <property type="nucleotide sequence ID" value="XM_447765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPS9"/>
    <dbReference type="FunCoup" id="Q6FPS9">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPS9"/>
    <dbReference type="GeneID" id="2889834"/>
    <dbReference type="KEGG" id="cgr:2889834"/>
    <dbReference type="CGD" id="CAL0133754">
        <property type="gene designation" value="CTF13"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01243g"/>
    <dbReference type="eggNOG" id="ENOG502QRJV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046445_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPS9"/>
    <dbReference type="OMA" id="WYTFKEY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031518">
        <property type="term" value="C:CBF3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19611">
        <property type="entry name" value="Ctf13_LRR_LRR-insertion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0133754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="54598" checksum="BAD4ED617BBA53C2" modified="2004-07-19" version="1">MVEERFNTLRFLDQPYEVRKLVYYHLDGQYTNANPPALDALYHGAIEIPNVRDYGGSKKVKKYYRQLVKKLYPLFEQYLQNFQYSPAMIESWLEYSLWLRYDAIVLDSLRLNHLYDGELVGPLDWIEIDGDLRLAVINKLYMLQVWYSYGEYKRWVIRNNITDYGDMELGYLRLNLEMQRDGQIPNIIQKLRKKEQLNLISEINFTTNIDTVTNGNANGNVKRGTNLKRARSDSPDVYLEDPMVKERYQIPNDPALTETIVNLEEMKQVSSLSVRGKNLYESLINVHGARDNPGRTISYISRRRVMRIAMNQVLNPSETGLADLTKWVNLRVISINDCGFIDLNKLILPSKAISLSLSNIRELRWWEFEMDSAIQAQFQQNKLLPYRPLFDLCEAGIHYTLDKKSISLVELKKFQTTIWKKLQALNWIKINNVAMISNKFIVIPKTLYESKRTVIFSTTVHSNIVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPU5</accession>
    <name>Q6FPU5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="15">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SDH1</name>
        <name evidence="19 20" type="ordered locus">CAGL0J00847g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 15">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="15"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447749.1">
        <property type="nucleotide sequence ID" value="XM_447749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPU5"/>
    <dbReference type="FunCoup" id="Q6FPU5">
        <property type="interactions" value="812"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPU5"/>
    <dbReference type="KEGG" id="cgr:2889870"/>
    <dbReference type="CGD" id="CAL0133218">
        <property type="gene designation" value="SDH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J00847g"/>
    <dbReference type="eggNOG" id="KOG2403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_1_1"/>
    <dbReference type="InParanoid" id="Q6FPU5"/>
    <dbReference type="OMA" id="PTGIWRM"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="4 15" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="17">
        <location>
            <begin position="125"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="18">
        <location>
            <begin position="575"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="503"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="519"/>
            <end position="520"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="14">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0133218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG60696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="710" mass="77652" checksum="CFE2B930028238D5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPZ7</accession>
    <name>Q6FPZ7_CANGA</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I10516g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447697.1">
        <property type="nucleotide sequence ID" value="XM_447697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPZ7"/>
    <dbReference type="FunCoup" id="Q6FPZ7">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPZ7"/>
    <dbReference type="KEGG" id="cgr:2889246"/>
    <dbReference type="CGD" id="CAL0129608">
        <property type="gene designation" value="CAGL0I10516g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I10516g"/>
    <dbReference type="eggNOG" id="ENOG502RJFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018313_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPZ7"/>
    <dbReference type="OMA" id="TEEEIMY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097446">
        <property type="term" value="P:protein localization to eisosome filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="712"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="460"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="229"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="712"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="813" mass="93373" checksum="C2D3E7841717AC06" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-02-28" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ03</accession>
    <name>TPO3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multidrug transporter TPO3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Drug:H(+) antiporter TPO3</fullName>
            <shortName evidence="7">DHA TPO3</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyamine transporter 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TPO3</name>
        <name type="ordered locus">CAGL0I10384g</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2014" name="J. Antimicrob. Chemother." volume="69" first="1767" last="1776">
            <title>Candida glabrata drug:H+ antiporter CgTpo3 (ORF CAGL0I10384g): role in azole drug resistance and polyamine homeostasis.</title>
            <authorList>
                <person name="Costa C."/>
                <person name="Nunes J."/>
                <person name="Henriques A."/>
                <person name="Mira N.P."/>
                <person name="Nakayama H."/>
                <person name="Chibana H."/>
                <person name="Teixeira M.C."/>
            </authorList>
            <dbReference type="PubMed" id="24576949"/>
            <dbReference type="DOI" id="10.1093/jac/dku044"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="526" last="526">
            <title>Clotrimazole drug resistance in Candida glabrata clinical isolates correlates with increased expression of the drug:H(+) antiporters CgAqr1, CgTpo1_1, CgTpo3, and CgQdr2.</title>
            <authorList>
                <person name="Costa C."/>
                <person name="Ribeiro J."/>
                <person name="Miranda I.M."/>
                <person name="Silva-Dias A."/>
                <person name="Cavalheiro M."/>
                <person name="Costa-de-Oliveira S."/>
                <person name="Rodrigues A.G."/>
                <person name="Teixeira M.C."/>
            </authorList>
            <dbReference type="PubMed" id="27148215"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.00526"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Cell membrane polyamine/proton antiporter, involved in the detoxification of excess polyamines in the cytoplasm (PubMed:24576949, PubMed:27148215). Involved in the resistance to the imidazole antifungal drugs tioconazole, miconazole, clotrimazole and ketoconazole; to the triazole fluconazole; but not to the antifungals flucytosine or amphotericin B (PubMed:24576949). Plays a role in spermine homeostasis, but spermine accumulation in response to clotrimazole is independent of TPO3 (PubMed:24576949, PubMed:27148215).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is up-regulated under spermine stress and depends on the pleiotropic drug resistance transcription factor PDR1 (PubMed:24576949).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 5">Increases the susceptibility to the imidazole antifungal drugs tioconazole, miconazole, clotrimazole and ketoconazole; to the triazole fluconazole; but not to the antifungals flucytosine or amphotericin B (PubMed:24576949, PubMed:27148215).</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ03"/>
    <dbReference type="SMR" id="Q6FQ03"/>
    <dbReference type="FunCoup" id="Q6FQ03">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ03"/>
    <dbReference type="GlyCosmos" id="Q6FQ03">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0I10384g-T">
        <property type="protein sequence ID" value="CAGL0I10384g-T-p1"/>
        <property type="gene ID" value="CAGL0I10384g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889240"/>
    <dbReference type="CGD" id="CAL0130223">
        <property type="gene designation" value="TPO3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I10384g"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_5_1"/>
    <dbReference type="InParanoid" id="Q6FQ03"/>
    <dbReference type="OMA" id="TMIMTEP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000296">
        <property type="term" value="P:spermine transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000443416" description="Multidrug transporter TPO3">
        <location>
            <begin position="1"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="553"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="24576949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="27148215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="6">
        <source>
            <dbReference type="PubMed" id="24576949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="27148215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="630" mass="70068" checksum="B336BAD1B3150B22" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ18</accession>
    <name>Q6FQ18_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I09856g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ18"/>
    <dbReference type="KEGG" id="cgr:2889274"/>
    <dbReference type="CGD" id="CAL0132162">
        <property type="gene designation" value="CAGL0I09856g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09856g"/>
    <dbReference type="eggNOG" id="ENOG502SABW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070628_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ18"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="274" mass="31014" checksum="7B82269FA803BFC5" modified="2004-07-19" version="1">MEDICLTPNGKLVRASVCPETPNKKRKRLPDPCPGAHDHITPSKSQRQRGRLTFQPLSPEYEDEDEEERHLQEEQFQLRMRRLRCNGSISPLSEPELDQELELELDLGLQGQGSVPLHKAHTQEINAKVQQGLTLPMHKKATVPQKQVQVKVQQQIQIHGKKHTPRHKVMKPTRSILRIAHGSLNYVVSSSRGSVADATIYATEINATTTTEKMPMVTQPWEKLTIPVNTAIKDKYRRMKAEYFHEETLDAQLLEVPDAAIIRGLAFSPSTSSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-02" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ45</accession>
    <name>MIC12_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>MICOS complex subunit MIC12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Altered inheritance of mitochondria protein 5, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Found in mitochondrial proteome protein 51</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">AIM5</name>
        <name type="synonym">FMP51</name>
        <name type="ordered locus">CAGL0I09262g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MICOS complex subunit Mic12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ45"/>
    <dbReference type="FunCoup" id="Q6FQ45">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ45"/>
    <dbReference type="EnsemblFungi" id="CAGL0I09262g-T">
        <property type="protein sequence ID" value="CAGL0I09262g-T-p1"/>
        <property type="gene ID" value="CAGL0I09262g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889123"/>
    <dbReference type="CGD" id="CAL0132312">
        <property type="gene designation" value="CAGL0I09262g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I09262g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09262g"/>
    <dbReference type="eggNOG" id="ENOG502S8MU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164154_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ45"/>
    <dbReference type="OMA" id="DIWNEQI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031463">
        <property type="entry name" value="Mic12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17050">
        <property type="entry name" value="AIM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000399889" description="MICOS complex subunit MIC12">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="114" mass="13560" checksum="67ABB72416D71863" modified="2004-07-19" version="1">MSKIAKLGSFTLVSGVVATSCYYYFIDRDGYHYKRSVWKQVGDEVQRVIDRKPSLVFSKEKYGDQFDYDYKVSGERVERVPVDHKQLVLRYNSETMKDLWNKEVRALVDWVYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ56</accession>
    <name>Q6FQ56_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Histidinol-phosphatase</fullName>
            <shortName evidence="8">HolPase</shortName>
            <ecNumber evidence="3 8">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0I09009g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-histidinol phosphate + H2O = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="3 8"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ56"/>
    <dbReference type="FunCoup" id="Q6FQ56">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ56"/>
    <dbReference type="KEGG" id="cgr:2889018"/>
    <dbReference type="CGD" id="CAL0132250">
        <property type="gene designation" value="CAGL0I09009g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09009g"/>
    <dbReference type="eggNOG" id="ENOG502RXUQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054611_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FQ56"/>
    <dbReference type="OMA" id="DYDRPMY"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000088">
        <property type="entry name" value="Histidinol-phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="HISTIDINOL PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039:SF0">
        <property type="entry name" value="HISTIDINOL-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="9">
        <location>
            <begin position="4"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0132250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="340" mass="38617" checksum="D7842044BB7B74AE" modified="2004-07-19" version="1">MHSHHSHSGDYVAHGVDPLDDIVAQAVAMRFHTYCLTEHMPRVNSKYLYPEERQEDMSPDPNIGELGLKVLKEKFLSYLEHSRSIRAKYSGGDCKTKFLVGCELECCDVEHIEYSKYLLRTYGDDLKFTVGSIHHIRGIPIDFDPHSWNEAFDSCDKNIVKFLSSYFDMQHAMITELQPIIIGHFDLYKLLLPDEMFVHPATGDCSDDPQVDFVPITSISLVKTFPILREKIIRNLKAIDSYGGAIEINTAGFRKGLCEPYPGPEICELAKQYCGSRFVLSDDAHAVSHVGTCYKQALDYITNTIKIEALYHLEETSDGSVKLVKEDMASVSENSFWKQF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQH3</accession>
    <name>JJJ2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>J protein JJJ2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">JJJ2</name>
        <name type="ordered locus">CAGL0I06226g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447521.1">
        <property type="nucleotide sequence ID" value="XM_447521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQH3"/>
    <dbReference type="SMR" id="Q6FQH3"/>
    <dbReference type="STRING" id="284593.Q6FQH3"/>
    <dbReference type="EnsemblFungi" id="CAGL0I06226g-T">
        <property type="protein sequence ID" value="CAGL0I06226g-T-p1"/>
        <property type="gene ID" value="CAGL0I06226g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889153"/>
    <dbReference type="KEGG" id="cgr:2889153"/>
    <dbReference type="CGD" id="CAL0132588">
        <property type="gene designation" value="CAGL0I06226g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06226g"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_601280_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQH3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000333576" description="J protein JJJ2">
        <location>
            <begin position="1"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="455" mass="52000" checksum="D254B43C415BC965" modified="2004-07-19" version="1">MSINDVTIDTSTYYSILGVPTNASTNEIRKSYMKLAKKLHPDKTKSEHTAELFKLVVDAHSILNNDQLRAEYDKKLILEGRFELHQHGAKQKNKDIRKGYTFKRNSKPYEQQPYGFGVQVPKGPHEESNYEANSNPHNENSSNNDTKMKSTNLHDTLSKDSEDKHGTDDASDIQPPTKSNDIANEVGSKRKSNSKDIHQDHSSNIGLNPLKKKKLEKKAVHATTTESRRYMRKKSEKKATPPIQPLADLQINDDWEKLREVLQRIEKEDSRGGKEFTLDIDVNEQMYNLSMESSDDEHTIPTKKRAKVGSNIQGNSRYFAQTAAYDMNQINANLGTRNTEDDRQASSKISITEIDDILDLLKERVPSPPKLGHLGVQRDQQNRALEYIKYTDELKKRILYVLSNSSTTEAMQHFNRHTQSVLAHKTMELRLCEKLTEIQKCQQGVIEYFSRTALG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-23" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQU2</accession>
    <name>CMR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA damage-binding protein CMR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAGL0I03542g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat DDB2/WDR76 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQU2"/>
    <dbReference type="SMR" id="Q6FQU2"/>
    <dbReference type="FunCoup" id="Q6FQU2">
        <property type="interactions" value="854"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQU2"/>
    <dbReference type="EnsemblFungi" id="CAGL0I03542g-T">
        <property type="protein sequence ID" value="CAGL0I03542g-T-p1"/>
        <property type="gene ID" value="CAGL0I03542g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889181"/>
    <dbReference type="CGD" id="CAL0132616">
        <property type="gene designation" value="CAGL0I03542g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03542g"/>
    <dbReference type="eggNOG" id="KOG4328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017019_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FQU2"/>
    <dbReference type="OMA" id="DPNTLYW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050853">
        <property type="entry name" value="WD_repeat_DNA-damage-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14773:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000351103" description="DNA damage-binding protein CMR1">
        <location>
            <begin position="1"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1" evidence="2">
        <location>
            <begin position="198"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2" evidence="2">
        <location>
            <begin position="254"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3" evidence="2">
        <location>
            <begin position="346"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4" evidence="2">
        <location>
            <begin position="403"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5" evidence="2">
        <location>
            <begin position="457"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6" evidence="2">
        <location>
            <begin position="498"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q12510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="534" mass="60651" checksum="282C04205761DF41" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR08</accession>
    <name>Q6FR08_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I01958g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR08"/>
    <dbReference type="FunCoup" id="Q6FR08">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR08"/>
    <dbReference type="KEGG" id="cgr:2888947"/>
    <dbReference type="CGD" id="CAL0129489">
        <property type="gene designation" value="CAGL0I01958g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01958g"/>
    <dbReference type="eggNOG" id="KOG2043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002149_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR08"/>
    <dbReference type="OMA" id="QRFYIQR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031906">
        <property type="entry name" value="RTT107_BRCT_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16771">
        <property type="entry name" value="RTT107_BRCT_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="69"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="126"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="366"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="785"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1099" mass="126024" checksum="B252B166CFAB8260" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR55</accession>
    <name>Q6FR55_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0I00814g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). The 5 acidic ribosomal P-proteins form the stalk structure of the 60S subunit. They are organized as a pentameric complex in which uL10/P0 interacts with 2 heterodimers, P1A-P2B and P1B-P2A.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR55"/>
    <dbReference type="FunCoup" id="Q6FR55">
        <property type="interactions" value="872"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR55"/>
    <dbReference type="KEGG" id="cgr:2889041"/>
    <dbReference type="CGD" id="CAL0132444">
        <property type="gene designation" value="CAGL0I00814g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00814g"/>
    <dbReference type="eggNOG" id="KOG1762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FR55"/>
    <dbReference type="OMA" id="YSAHDHE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0132444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="107" mass="10701" checksum="1D0844A5C26377FC" modified="2004-07-19" version="1">MSTESALAYAALILADAEVEITSEKLVTLTGAAHIPVEGIWADIFAKALDGQDLKSLLVNFSAGPAAAVGGAASAGAAAGGDAAAAEEKEEEAKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR67</accession>
    <name>Q6FR67_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I00550g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447277.1">
        <property type="nucleotide sequence ID" value="XM_447277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR67"/>
    <dbReference type="KEGG" id="cgr:2889300"/>
    <dbReference type="CGD" id="CAL0132606">
        <property type="gene designation" value="CAGL0I00550g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00550g"/>
    <dbReference type="HOGENOM" id="CLU_2621786_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR67"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="78" mass="8767" checksum="F734890E1EA8D58A" modified="2004-07-19" version="1">MELLGYDTSAFDAMYNVIKNSLFSSGQSFHEEPIENVIALFVICSIVMIMIMSCVVIMMMLLTINNKSTENDLEAGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR70</accession>
    <name>Q6FR70_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="9">3.2.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0I00484g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="9"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR70"/>
    <dbReference type="FunCoup" id="Q6FR70">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR70"/>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889406"/>
    <dbReference type="CGD" id="CAL0130502">
        <property type="gene designation" value="CAGL0I00484g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00484g"/>
    <dbReference type="eggNOG" id="ENOG502QPYU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004624_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FR70"/>
    <dbReference type="OMA" id="TKQYWKD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273511" description="glucan 1,3-beta-glucosidase" evidence="11">
        <location>
            <begin position="20"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="103"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0130502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG60211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="443" mass="51158" checksum="2A542CA0A47052EA" modified="2004-07-19" version="1">MVSFSFATIVAALSVSALAKPVIAPKNKDTSLHFVNEKRYYDYDSKAIGEPIRGVNIGGWFVLEPYITPSLFEAFRTNPYNDDGIPVDEYHYCEQLGEQEARNRLEYHWSTFYTEQDFADIKSKGFNLVRIPIGYWAFKDMPNDPYVKGSQEYYLDQAIQWAENNGLKVWVDLHGAVGSQNGFDNSGLRDSIDFLADENLQNTKEILKYVLQKYSQQQYLNTVIGVELINEPLGPVIDMDKMKEQYIKPAYEYLRNELQSIQDIIVHDAFQPFHYWDDFMTVDTGYWGVVIDHHHYQVFSTGELQRDMGQHIQVACEWGSGILTESHWTVAGEWSAALTDCTKWLNGVGIGARYDGSFWKNGVSSSFIGSCANNEDIYSWSEERKENTRKYIEAQLDAFEKRGGWIFWCYKTETNIEWDASRLIEYGMFPQPLTDRRYPGQCA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2025-06-18" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRB7</accession>
    <name>IPYR_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Inorganic pyrophosphatase</fullName>
            <ecNumber>3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Pyrophosphate phospho-hydrolase</fullName>
            <shortName>PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">IPP1</name>
        <name type="ordered locus">CAGL0H09878g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447227.1">
        <property type="nucleotide sequence ID" value="XM_447227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRB7"/>
    <dbReference type="SMR" id="Q6FRB7"/>
    <dbReference type="FunCoup" id="Q6FRB7">
        <property type="interactions" value="1123"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRB7"/>
    <dbReference type="EnsemblFungi" id="CAGL0H09878g-T">
        <property type="protein sequence ID" value="CAGL0H09878g-T-p1"/>
        <property type="gene ID" value="CAGL0H09878g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888731"/>
    <dbReference type="KEGG" id="cgr:2888731"/>
    <dbReference type="CGD" id="CAL0131448">
        <property type="gene designation" value="IPP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H09878g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09878g"/>
    <dbReference type="eggNOG" id="KOG1626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040684_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FRB7"/>
    <dbReference type="OMA" id="LYANEQK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000137581" description="Inorganic pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="287" mass="32313" checksum="E4BEC0B55E442AAA" modified="2004-07-19" version="1">MVYTTRQIGAKNTLDYKVFIEEDGKPVSPFHDIPLYADKEENIFNMVVEIPRWTNAKLEITKEETLNPIIQDTKKGKLRYVRNCFPHHGYIHNYGAFPQTWEDPNQTHPETKAVGDNDPVDVLEIGETIGYTGQVKQVKVLGIMALLDEGETDWKVIAIDINDPLAPKLNDIEDVEKYFPGLLRATNEWFRIYKIPDGKPENQFAFSGEAKNKKYALDIIKETNESWKQLIAGKSTDSKDIALENTKVTDSPYYSASAASAIPAAAPQADAPIDKSVDKWFFISGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRK8</accession>
    <name>Q6FRK8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0H07777g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRK8"/>
    <dbReference type="SMR" id="Q6FRK8"/>
    <dbReference type="FunCoup" id="Q6FRK8">
        <property type="interactions" value="1205"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRK8"/>
    <dbReference type="KEGG" id="cgr:2888545"/>
    <dbReference type="CGD" id="CAL0129605">
        <property type="gene designation" value="CAGL0H07777g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07777g"/>
    <dbReference type="eggNOG" id="KOG2274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008920_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FRK8"/>
    <dbReference type="OMA" id="NPDQYTI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000511">
        <property type="term" value="F:H2A-H2B histone complex chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058669">
        <property type="entry name" value="TPR_IPO7/11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25758">
        <property type="entry name" value="TPR_IPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="908"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1021" mass="114740" checksum="2DB5DAAD753D0B64" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS32</accession>
    <name>Q6FS32_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0H03861g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446962.1">
        <property type="nucleotide sequence ID" value="XM_446962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS32"/>
    <dbReference type="STRING" id="284593.Q6FS32"/>
    <dbReference type="KEGG" id="cgr:2888871"/>
    <dbReference type="CGD" id="CAL0131994">
        <property type="gene designation" value="CAGL0H03861g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03861g"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026447_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FS32"/>
    <dbReference type="OMA" id="AYRIVEY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21605">
        <property type="entry name" value="RRM1_HRB1_GBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21606">
        <property type="entry name" value="RRM2_HRB1_GBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21607">
        <property type="entry name" value="RRM3_HRB1_GBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="107"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="217"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="361"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="443" mass="49258" checksum="DEC2408A01E41C2D" modified="2004-07-19" version="1">MSEAQRSRSRSPVRRSLSSYATRRGFERPSNDGRPPAERGPRPGSSRGGRGHERRRFNGAGPSERGGVNKFRRDKEKAARTKGDFGPRLARELDSTYEEKVNRNYTNSIFVGNLTYDCTPEDLKDFFSQVGKVVRADIITSRGHHRGMGTVEFTSGEEVDEAIRKFDGAYLMNRQIFVRQDNPPPESSSTHSSGSNSGHTTNVTKPKKAVKPQKKGYELMILNLPYSISWQTLKTMFKEFGDVLKANVEVDSTGMSIGVGNVIFKNQEDMVKAYEHFNGFEIEGKVLEVRGQIPDPTQISSTRKTDDLTVNQDNEDIEMDIDTAEGGDEKALKADVSSDGGARAQNKFSSDDYVKTEDKSKIILCDNLPGATTEGDLYDLFETLGKVKTAGFINTDNAGETVSAIVIYNEQDDAEVCYGRLQGYNYGGCDLKISYVKDKNIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS83</accession>
    <name>Q6FS83_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein UTP30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H02673g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS83"/>
    <dbReference type="FunCoup" id="Q6FS83">
        <property type="interactions" value="412"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS83"/>
    <dbReference type="KEGG" id="cgr:2888651"/>
    <dbReference type="CGD" id="CAL0130194">
        <property type="gene designation" value="CAGL0H02673g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02673g"/>
    <dbReference type="eggNOG" id="KOG1685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063901_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS83"/>
    <dbReference type="OMA" id="ADFRVHH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0130194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="30390" checksum="442301D40B5781B8" modified="2004-07-19" version="1">MAPSLCDSAFARKGVDALISYATNQDSNNDIQLIIHTEKKLGIKKDYIPRVIPLKHNKMSKVKDMRILLITKDPANKYRDVLTSNELTSDTFKEIISVKNLKRRFRGSKLTSLYKEFDMVVADFRVHHLLPAILGSRFYHSSKKTPYMVRINKEVKHKGAKMDETIDPVYLKAQLKSICRNTSYMPNEDNCINVKVGFVSTHTAKQILENIQDVIEFLSDKNMKPSGGVIKGSIKSLQVKTASSASIPIYQYNENKEKNIPNDRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS93</accession>
    <name>Q6FS93_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0H02431g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FS93">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS93"/>
    <dbReference type="KEGG" id="cgr:2888887"/>
    <dbReference type="CGD" id="CAL0132018">
        <property type="gene designation" value="CAGL0H02431g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02431g"/>
    <dbReference type="eggNOG" id="KOG1810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001011_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FS93"/>
    <dbReference type="OMA" id="TQHITRR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002130">
        <property type="term" value="P:wobble position ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="4">
        <location>
            <begin position="226"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="3">
        <location>
            <begin position="612"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="5">
        <location>
            <begin position="829"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0132018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1416" mass="163256" checksum="9C71D377A477C01B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSA4</accession>
    <name>Q6FSA4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein TMA23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H02189g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="gene designation" value="CAGL0H02189g"/>
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    <dbReference type="eggNOG" id="ENOG502S9CM">
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        <property type="component" value="Chromosome H"/>
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        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:ribosomal small subunit biogenesis"/>
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    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF26">
        <property type="entry name" value="PROTEIN TMA23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59823.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22263" checksum="CACA56F0643F9A40" modified="2004-07-19" version="1">MDGKSYLKSYGWQEGEGLRKGSLKKPILVKHKRDKKGLGGAVGHNDGEAWWERLFDGQLKNLDVSTDSNSDGEIVFKQNSVVASGVPKSSSPLYQWFVKGTGLKGTIDEKPDLKESKTVTVVSDSFKVSKKRKYDEDYKVSKKHKKDKKAKKDKKAKKDKKAKKDKKDKKDKKDKKDKKDKKDKKDKKAKSKSKGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSL9</accession>
    <name>Q6FSL9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G09559g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSL9"/>
    <dbReference type="FunCoup" id="Q6FSL9">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSL9"/>
    <dbReference type="KEGG" id="cgr:2888391"/>
    <dbReference type="CGD" id="CAL0137771">
        <property type="gene designation" value="CAGL0G09559g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09559g"/>
    <dbReference type="eggNOG" id="ENOG502QUEY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004952_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSL9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04401">
        <property type="entry name" value="RhoGAP_fMSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="52"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="933"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1094"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="837"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="891"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1007"/>
        </location>
    </feature>
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        <location>
            <begin position="1013"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1208" mass="136858" checksum="4ACDFCB7A537D69D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FST3</accession>
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    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0G08019g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FST3"/>
    <dbReference type="KEGG" id="cgr:2888249"/>
    <dbReference type="CGD" id="CAL0129369">
        <property type="gene designation" value="CAGL0G08019g"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2913">
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    <dbReference type="HOGENOM" id="CLU_040201_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FST3"/>
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        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Putative membrane protein"/>
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        <property type="entry name" value="PQ-loop_rpt"/>
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    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
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        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CTNS"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="6"/>
            <end position="28"/>
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            <dbReference type="EMBL" id="CAG59638.1"/>
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    <sequence length="316" mass="35779" checksum="58E3A64441BF70D4" modified="2004-07-19" version="1">MISEGAATTLATIATVCWCVQLIPQIIYNWRRKDCTGLPPLMMFLWVVSGIPFAIYFCVSKGNVVLQIQPHLFMFFCGISFVQSCYYPPCSLAVRKIVAIVVGIIVVDIGMEVGFILWLRPLYSRGITWPDLIFGIIATVLLAIGLLPPYFELAKRNGRVVGINFIFLFIDSLGAWLSIISVVVGNMDTMGIILYSVIAGLELGIFLSHFIWCCRFKWFGNHDPEETDAVSEEKSVKDTQYDEKDGSLSKNKMGHDAMFSKTEEVNETDEPRDDVSSFDYDLERRPSHMERFSQKVHAVHGVVMQRPEQVYHNVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSW1</accession>
    <name>Q6FSW1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inner nuclear membrane protein SRC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0G07403g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="component" value="Chromosome G"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="MAN1, winged-helix domain"/>
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        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HeH/LEM_domain"/>
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        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
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        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="682"/>
            <end position="700"/>
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    </feature>
    <feature type="domain" description="HeH/LEM" evidence="10">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="9">
        <location>
            <begin position="438"/>
            <end position="790"/>
        </location>
    </feature>
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        <location>
            <begin position="51"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="314"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="619"/>
            <end position="647"/>
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    </feature>
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        <location>
            <begin position="110"/>
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        </location>
    </feature>
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        <location>
            <begin position="141"/>
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        </location>
    </feature>
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        <location>
            <begin position="216"/>
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            <begin position="236"/>
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        <location>
            <begin position="620"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0129239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="806" mass="91487" checksum="7E0FF4794C2EC7BF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT00</accession>
    <name>Q6FT00_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0G06490g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT00"/>
    <dbReference type="FunCoup" id="Q6FT00">
        <property type="interactions" value="1216"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT00"/>
    <dbReference type="KEGG" id="cgr:2888104"/>
    <dbReference type="CGD" id="CAL0137573">
        <property type="gene designation" value="CAGL0G06490g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06490g"/>
    <dbReference type="eggNOG" id="KOG3320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088621_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FT00"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0137573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="188" mass="21544" checksum="7342BCE4B06C9C4A" modified="2004-07-19" version="1">MSAQAKILSQAPTELELQFAQAFIDLENSSPELKAELRPLQFRSVREIDVAAGKKALAVFVPVPSLTGYHKVQTKLTRELEKKFPDRHVIFLAERRILPKPSRKSRQTQKRPRSRTLSAVHDKILEDLVFPTEIVGKRVRYLVGGNKIQKVLLDSKDIQQIDYKLESFQAVYNKLTGKQIVFEIPETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT28</accession>
    <name>Q6FT28_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxycytidylate deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0G05852g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT28"/>
    <dbReference type="FunCoup" id="Q6FT28">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT28"/>
    <dbReference type="KEGG" id="cgr:2888266"/>
    <dbReference type="CGD" id="CAL0137591">
        <property type="gene designation" value="CAGL0G05852g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05852g"/>
    <dbReference type="eggNOG" id="KOG3127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT28"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000035">
        <property type="entry name" value="dCMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="10">
        <location>
            <begin position="157"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0137591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="307" mass="34909" checksum="820CF9F0B214C637" modified="2004-07-19" version="1">MLVVVSGAQYNGVERVVDILVDGFGFERLSAVDDHELLLEYVTKNYTRNLVLHCDDLELYLKLEKRPFLIHISIEAPLALRLQLSGLTPEEFINVADLDHFKDDKIRLVERAHLKFKLVDCDLSTLDNRLKENIENQLRVLQSQDSLTLVNPPLRPDWDTYFMKLATLAASRSNCMKRRVGCVIVRECRVIATGYNGTPRHLTNCFHGGCPRCNDGDSKNLHTCLCLHAEENALLEAGRDRVGQNATLYCDTCPCLTCSVKIVQTGITEVVYSQTYRMDDASFKVLREAGIKVRQFSFREEPLLVFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTG1</accession>
    <name>DPH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="2">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DPH1</name>
        <name type="ordered locus">CAGL0G02761g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="2">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text>Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="2"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446483.1">
        <property type="nucleotide sequence ID" value="XM_446483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTG1"/>
    <dbReference type="SMR" id="Q6FTG1"/>
    <dbReference type="FunCoup" id="Q6FTG1">
        <property type="interactions" value="670"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTG1"/>
    <dbReference type="EnsemblFungi" id="CAGL0G02761g-T">
        <property type="protein sequence ID" value="CAGL0G02761g-T-p1"/>
        <property type="gene ID" value="CAGL0G02761g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888069"/>
    <dbReference type="KEGG" id="cgr:2888069"/>
    <dbReference type="CGD" id="CAL0130727">
        <property type="gene designation" value="CAGL0G02761g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_G02761g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02761g"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037146_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FTG1"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120513">
        <property type="term" value="C:2-(3-amino-3-carboxypropyl)histidine synthase complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000083370" description="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O58832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P40487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="428" mass="48907" checksum="769BFF46C099A796" modified="2004-07-19" version="1">MDNTTEKKEPTKVPRRRFVGKRKTDGKTITTVKADGNEVVRQTKSRVHVGRSLNHIPDDIMEDEELNEAIKLLPQNYNFEIHKTVWNIRKHGAKRVALQMPEGLLIYSLLISDILEQFCNVETVVMGDVSYGACCIDDFTARALDCDFIVHYAHSCLVPIDITEIKVLYVFVTIAIDETHVIKTLQKNFPKGSRLATFGTIQFNPTVHSIKDTLLNDKEHMLYIVTPQIKPLSRGEVLGCTSERLDKNQFDAMVFIGDGRFHLESSMIHNPEIPAFKYDPYNRKFTRERYDQKQLVQVRGEALQVAQKGKVFGLILGALGRQGNVDTVRNLEEKLIKAGKTVVKIILSEIFPQKLAKFDKIDVFVQVACPRLSIDWGYAFPKPLLTPYEANVLLNHDVMFSEEYYPMDYYETNGYGRGRIPEHALVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTR2</accession>
    <name>Q6FTR2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G00396g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTR2"/>
    <dbReference type="FunCoup" id="Q6FTR2">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTR2"/>
    <dbReference type="KEGG" id="cgr:2888284"/>
    <dbReference type="CGD" id="CAL0137749">
        <property type="gene designation" value="CAGL0G00396g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00396g"/>
    <dbReference type="HOGENOM" id="CLU_1030569_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTR2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018304">
        <property type="entry name" value="Rtt102"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09510">
        <property type="entry name" value="Rtt102p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="270" mass="29558" checksum="AD37ECBD7D447897" modified="2004-07-19" version="1">MTAESMIHRANKGGYGSSQDENIHYEYDWVRPVKVTENSQGGDGSDPLIGIGSESKESSFYGFKFKTWQKRNGGHPIEKDPVTLLNMDDFDRTKVSEKKKKLGKKLDGDDLSEDAIRGAVGGSDTVFSSSHAKPDTSGGMKRNETETEKQSDSNTQEQSTTSVKEEESKNETNDTEVTPESNAIEKDELASKLGDVQTPESGNLSEGQKPSDTQLLENDIKDETKSEIVEEDGNEVGDPVSEPVNEPVSNTVTPEGENNKEDNDIEMTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU17</accession>
    <name>Q6FU17_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nuclear polyadenylated RNA-binding protein NAB2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0F07095g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU17"/>
    <dbReference type="FunCoup" id="Q6FU17">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU17"/>
    <dbReference type="KEGG" id="cgr:2887926"/>
    <dbReference type="CGD" id="CAL0130888">
        <property type="gene designation" value="CAGL0F07095g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07095g"/>
    <dbReference type="eggNOG" id="KOG3702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037973_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FU17"/>
    <dbReference type="OMA" id="HAHPTKV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900152">
        <property type="term" value="P:negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160091">
        <property type="term" value="P:spliceosome-depend formation of circular RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000003">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein NAB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.40:FF:000002">
        <property type="entry name" value="Polyadenylated RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000005">
        <property type="entry name" value="Polyadenylated RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021083">
        <property type="entry name" value="Nab2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049017">
        <property type="entry name" value="Nab2_Znf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041044">
        <property type="entry name" value="Nab2p_Zf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048410">
        <property type="entry name" value="Znf-CCCH_2-like_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11517">
        <property type="entry name" value="Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21803">
        <property type="entry name" value="Nab2-zf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18260">
        <property type="entry name" value="Nab2p_Zf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21457">
        <property type="entry name" value="zf-CCCH_2-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear abundant poly(A) RNA-binding protein Nab2 N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1" evidence="10">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding Nab2-type zinc finger" evidence="11">
        <location>
            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Nab2 type CCCH zinc finger 4" evidence="12">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="125"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0130888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59005" checksum="04F58C8D0CC4B7F3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU50</accession>
    <name>LHS1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Heat shock protein 70 homolog LHS1</fullName>
            <ecNumber>3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LHS1</name>
        <name type="ordered locus">CAGL0F06369g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Chaperone required for protein translocation and folding in the endoplasmic reticulum.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446244.1">
        <property type="nucleotide sequence ID" value="XM_446244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU50"/>
    <dbReference type="SMR" id="Q6FU50"/>
    <dbReference type="FunCoup" id="Q6FU50">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU50"/>
    <dbReference type="GlyCosmos" id="Q6FU50">
        <property type="glycosylation" value="7 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0F06369g-T">
        <property type="protein sequence ID" value="CAGL0F06369g-T-p1"/>
        <property type="gene ID" value="CAGL0F06369g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887859"/>
    <dbReference type="KEGG" id="cgr:2887859"/>
    <dbReference type="CGD" id="CAL0130854">
        <property type="gene designation" value="CAGL0F06369g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06369g"/>
    <dbReference type="eggNOG" id="KOG0104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FU50"/>
    <dbReference type="OMA" id="DYGQQNI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000013555" description="Heat shock protein 70 homolog LHS1">
        <location>
            <begin position="16"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="811"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Prevents secretion from ER" evidence="2">
        <location>
            <begin position="886"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="820"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="868"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="462"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="716"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="889" mass="99634" checksum="58CD2D752B2DD11F" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU83</accession>
    <name>Q6FU83_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome B translational activator protein CBS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0F05533g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU83"/>
    <dbReference type="FunCoup" id="Q6FU83">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU83"/>
    <dbReference type="KEGG" id="cgr:2887587"/>
    <dbReference type="CGD" id="CAL0131222">
        <property type="gene designation" value="CAGL0F05533g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05533g"/>
    <dbReference type="eggNOG" id="ENOG502RI8G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_10_2_1"/>
    <dbReference type="InParanoid" id="Q6FU83"/>
    <dbReference type="OMA" id="NCKWNDI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0131222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42931" checksum="ECF46536A660B542" modified="2004-07-19" version="1">MSSVPRVYFAGSPLATLVGYGIARLPGQGKIPNVVMLMVDQLKLKRFMNHESQISLYRSSLMLDRLQLMAGYSVPRYANGDIAPFENLVIGGGDWRYTNSIMRKYESAIVPSTELLLLNPSLFTLGLVLEKKRNKEFKIWRERPKVTIGVANKAGVEIGNEEFDVRVNNNDIKIKYSHLPETLWANENDSIENSQNSINSLMNQINLHYPTATVGIQTEQVSFQEMFTNYCERELVDNTIEALCLLFDCSFIKELKDIKEAIHLTNLLVWEKLKILKSQFGFIEAFENSTIIFDDQRILGLIKDKINKSHEPSEFYENYQRFANKDILENVIYMSYLSHKLELKFSHVDLISRLIKGKVLAHKNRHLSTKLRS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUA6</accession>
    <name>DBP9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP9</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP9</name>
        <name type="ordered locus">CAGL0F04983g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446188.1">
        <property type="nucleotide sequence ID" value="XM_446188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUA6"/>
    <dbReference type="SMR" id="Q6FUA6"/>
    <dbReference type="FunCoup" id="Q6FUA6">
        <property type="interactions" value="1079"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUA6"/>
    <dbReference type="EnsemblFungi" id="CAGL0F04983g-T">
        <property type="protein sequence ID" value="CAGL0F04983g-T-p1"/>
        <property type="gene ID" value="CAGL0F04983g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887936"/>
    <dbReference type="KEGG" id="cgr:2887936"/>
    <dbReference type="CGD" id="CAL0130982">
        <property type="gene designation" value="CAGL0F04983g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04983g"/>
    <dbReference type="eggNOG" id="KOG0346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_17_1_1"/>
    <dbReference type="InParanoid" id="Q6FUA6"/>
    <dbReference type="OMA" id="NASEQCV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033677">
        <property type="term" value="F:DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232338" description="ATP-dependent RNA helicase DBP9">
        <location>
            <begin position="1"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="46"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="243"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="560"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="176"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="59"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="595" mass="67500" checksum="D8A9D25FA78AC3F8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUB9</accession>
    <name>Q6FUB9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0F04697g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446175.1">
        <property type="nucleotide sequence ID" value="XM_446175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUB9"/>
    <dbReference type="FunCoup" id="Q6FUB9">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887639"/>
    <dbReference type="CGD" id="CAL0131412">
        <property type="gene designation" value="CAGL0F04697g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04697g"/>
    <dbReference type="eggNOG" id="ENOG502S0IJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060982_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUB9"/>
    <dbReference type="OMA" id="DARMYST"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="372" mass="41492" checksum="9B35C23A3F57AC0C" modified="2004-07-19" version="1">MSAERYPSVPSLVGDSVRSIKGTGTEPVARSDPRNDVKILNKLHDTVANHNQSQQLSGSSYTSVEDLNKEGALLTDEVDLELSHVDGKVQRKDGEVDFNIADRKLGESELEKQRKRKLMLLKQKQKNRELSSTSLSRMDIQSSSSQTSLTHLDDETKEELDRVSRSQERERQRGSQMVSPTRGSDGLVRNSYGEYIKSTCNRPHLARGDSYQSSSNESENNLIDSAATPSERSGRTSFRRRLSTEYLRSLSRSLSRDPSKSTTRTNAITPSHSNNAGNYTTSAPPSHHVVAIPGGDFIDNEKTRTVDQSLEDELYSTNNYSISQVELAQAANKTLLNEAFDEEEEEGALLDDQGNEEHDRELERAAIKVEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUC6</accession>
    <name>Q6FUC6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein ECM13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0F04521g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUC6"/>
    <dbReference type="STRING" id="284593.Q6FUC6"/>
    <dbReference type="KEGG" id="cgr:2887628"/>
    <dbReference type="CGD" id="CAL0129414">
        <property type="gene designation" value="CAGL0F04521g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04521g"/>
    <dbReference type="eggNOG" id="ENOG502SDCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_973174_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUC6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32101" checksum="4CA1B7516701B8DB" modified="2004-07-19" version="1">MLAIHFNNSLSLQDQYSLASKARTKLMRCAKDAQKANKEYNLRVLVGHANLLDRITENVERMNLIKRQQQNVADDLQLSKQNSNVVEGYTHAGEVSAQNKTSTSDYYYYSSESESESESDSESESDYESETEAQGDFTFKVDESIDCKENTEVVDSEVSVAEECNYVVGAGAHYAGHNDSSNKHFTTIWEEPSEGDNTTEEKTEICLSSSITSTGNDCDEKAKDYKETTDVCSGSDSDEHSLNSPLDDNDAFESYDDICKSSNDYGVHYHKNHDNYFNIPQHKTLV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUI5</accession>
    <name>LCMT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber>2.1.1.233</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Protein phosphatase methyltransferase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PPM1</name>
        <name type="ordered locus">CAGL0F03201g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446109.1">
        <property type="nucleotide sequence ID" value="XM_446109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUI5"/>
    <dbReference type="SMR" id="Q6FUI5"/>
    <dbReference type="FunCoup" id="Q6FUI5">
        <property type="interactions" value="579"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUI5"/>
    <dbReference type="EnsemblFungi" id="CAGL0F03201g-T">
        <property type="protein sequence ID" value="CAGL0F03201g-T-p1"/>
        <property type="gene ID" value="CAGL0F03201g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887677"/>
    <dbReference type="KEGG" id="cgr:2887677"/>
    <dbReference type="CGD" id="CAL0129824">
        <property type="gene designation" value="CAGL0F03201g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03201g"/>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031312_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FUI5"/>
    <dbReference type="OMA" id="IIYEPIR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000226125" description="Leucine carboxyl methyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="156"/>
            <end position="157"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="318" mass="36688" checksum="87B0251B45126D2A" modified="2004-07-19" version="1">MELAVQRTDTDALSSKVSAIHTKYLSGGISQQFAYEEVYGEYLASLRQVSRRVFGKCRYSGASFPVMNYGTYLRTVAIDERVLEFLQCNSGSQVQIVNIGCGSDLRMVSVLAKHSNVKYIDLDFKESVELKRQVLEKSSTLSSYLKNDNYVLRSCDLRDVPDTLELLNEECKPELPTLIISECVLCYMPEKETQSLIDGIIRLFKNGSWVSYDPMGGSDKNDRFGVIMQQNLRDSRQLEMPTLLINNSPEIYASRWTPNSDEQFERVVTDMWTYYNDKVPAEEKQRIKRLQFLDELEELKVMQSHYVIFFCKWNANPN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUJ7</accession>
    <name>SYF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor SYF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SYF1</name>
        <name type="ordered locus">CAGL0F02915g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing and cell cycle progression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446097.1">
        <property type="nucleotide sequence ID" value="XM_446097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUJ7"/>
    <dbReference type="SMR" id="Q6FUJ7"/>
    <dbReference type="FunCoup" id="Q6FUJ7">
        <property type="interactions" value="1143"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUJ7"/>
    <dbReference type="EnsemblFungi" id="CAGL0F02915g-T">
        <property type="protein sequence ID" value="CAGL0F02915g-T-p1"/>
        <property type="gene ID" value="CAGL0F02915g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887745"/>
    <dbReference type="KEGG" id="cgr:2887745"/>
    <dbReference type="CGD" id="CAL0129874">
        <property type="gene designation" value="CAGL0F02915g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02915g"/>
    <dbReference type="eggNOG" id="KOG2047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007736_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUJ7"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000137">
        <property type="entry name" value="Pre-mRNA-splicing factor syf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000205727" description="Pre-mRNA-splicing factor SYF1">
        <location>
            <begin position="1"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 1">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 2">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 3">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 4">
        <location>
            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 5">
        <location>
            <begin position="458"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 6">
        <location>
            <begin position="517"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 7">
        <location>
            <begin position="589"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 8">
        <location>
            <begin position="628"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 9">
        <location>
            <begin position="707"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 10">
        <location>
            <begin position="743"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="835" mass="98986" checksum="A740D838E526176A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUU5</accession>
    <name>Q6FUU5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0F00583g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUU5"/>
    <dbReference type="FunCoup" id="Q6FUU5">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUU5"/>
    <dbReference type="KEGG" id="cgr:2887666"/>
    <dbReference type="CGD" id="CAL0131014">
        <property type="gene designation" value="CAGL0F00583g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00583g"/>
    <dbReference type="eggNOG" id="KOG3834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_742267_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUU5"/>
    <dbReference type="OMA" id="SSTQHIW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106103">
        <property type="term" value="C:COPII vesicles tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000183">
        <property type="entry name" value="Golgi reassembly-stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="179"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="306"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0131014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="372" mass="40912" checksum="45F5BF3989DF4536" modified="2004-07-19" version="1">MFKIAKNLVKTFEQTLSLSDQDRLDGFFQSIPPNLLESQIHSNTDMSTLSDVLSGLRVVYVDELQLQLESYFDFIVGIDDDPLPLMNNQHGYLYPDYNEIIRLLNIHAEQASPVKLNVWSAKGGTFRDEYMSLSAIPSDENQMEDINLSNDTPHHQLSSKIFSPLGFKVQWTPLIAATYTYHVLQLNIEGGPAHAAGLIPDEDYIIGSQDGLLATGGETLLQDLIRSRANHDLILYVYNKVVDCVRPVTVNIGPDGRLGCGVGYGFLHRIPTVRKQEDGNTSMHSNKGITNAPTAAIPVPTFDQPMSSETFVPGIAKPPPTSKSSKKHAVNISTMGDYFSEGKDQSPTPKPSTGDKDASIPPPPSKNTEETQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUV2</accession>
    <name>ITPA_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="1">ITPase</shortName>
            <shortName evidence="1">Inosine triphosphatase</shortName>
            <ecNumber evidence="1">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="1">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">HAM1</name>
        <name type="ordered locus">CAGL0F00429g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:28611"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="1"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445992.1">
        <property type="nucleotide sequence ID" value="XM_445992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUV2"/>
    <dbReference type="SMR" id="Q6FUV2"/>
    <dbReference type="FunCoup" id="Q6FUV2">
        <property type="interactions" value="773"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUV2"/>
    <dbReference type="EnsemblFungi" id="CAGL0F00429g-T">
        <property type="protein sequence ID" value="CAGL0F00429g-T-p1"/>
        <property type="gene ID" value="CAGL0F00429g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887788"/>
    <dbReference type="KEGG" id="cgr:2887788"/>
    <dbReference type="CGD" id="CAL0131098">
        <property type="gene designation" value="CAGL0F00429g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_F00429g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00429g"/>
    <dbReference type="eggNOG" id="KOG3222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FUV2"/>
    <dbReference type="OMA" id="YDPIFQP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008828">
        <property type="term" value="F:dATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047840">
        <property type="term" value="F:dCTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036217">
        <property type="term" value="F:dGTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036219">
        <property type="term" value="F:GTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009217">
        <property type="term" value="P:purine deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009213">
        <property type="term" value="P:pyrimidine deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000009">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413132" description="Inosine triphosphate pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <sequence length="192" mass="21433" checksum="1ED9E0055476536A" modified="2004-07-19" version="1">MAPTEITFVTGNANKLKEVQMLLAAEDKKGSITLKNEPLDLDELQDVDLKAIALTKCKQAVKELGVGTPVFVEDTALTFDEFNGLPGAYIKWFLKSMSLEKIVKLLEPYSNKGAEAITTIAYCDENGEYHIFQGITKGKIVDSRGPTNFGWDSIFEPLEGKGMTYAEMEKDFKNTLSHRGKAFVEFKKFLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUX4</accession>
    <name>Q6FUX4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0E06446g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUX4"/>
    <dbReference type="FunCoup" id="Q6FUX4">
        <property type="interactions" value="716"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUX4"/>
    <dbReference type="KEGG" id="cgr:2887377"/>
    <dbReference type="CGD" id="CAL0128626">
        <property type="gene designation" value="CAGL0E06446g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06446g"/>
    <dbReference type="eggNOG" id="KOG2863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005893_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FUX4"/>
    <dbReference type="OMA" id="KWWFSAH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032197">
        <property type="term" value="P:retrotransposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016074">
        <property type="term" value="P:sno(s)RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="13">
        <location>
            <begin position="280"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0128626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="405" mass="47487" checksum="947109DE390DE2AA" modified="2004-07-19" version="1">MNERKLRIAVQGCCHGELNKVFATVADMHKRTPIDLLIILGDFQSIRDNSDFQSISIPPKYQKLGDFHAYYENDYYRAPVFTIVIGGNHESMRHLMQLPYGGYLANNIYYMGYSGVVWFKGFRIAALSGIWKEWDFEKKRPSWKFLEENNKWKDSVRQLYHIRKDDVAPLFALSDNIDICLSHDWPSGVVHYGNVKQLLKYKPFFEKDIKSGKLGNPIAWKLLTNLKPRWWFSAHLHVKYEAEITHNKRRLADSKGAKKLKSNSDEIELNLDDESSLDLSCHDDSLDSAEHTRFLSLDKCMPRRKWLEIVEIEKRYDSIPQGLDCDKMYWDPSYIIALQNLEKQSRLVADTPFNEIIWSRFSSGHIDDINWHKYEIPKYESGLQRDEASQTNYFLSKHMLSKGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV48</accession>
    <name>Q6FV48_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0E04796g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
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        <location>
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    </feature>
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            <end position="470"/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0128644"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG58815.1"/>
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    <sequence length="653" mass="73740" checksum="95A729EA1CBDA15E" modified="2004-07-19" version="1"> </sequence>
</entry>
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    <accession>Q6FVA3</accession>
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            <fullName evidence="5">Protein SPA2</fullName>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
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                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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            <end position="459"/>
        </location>
    </feature>
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        <location>
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            <end position="595"/>
        </location>
    </feature>
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        <location>
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        </location>
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        <location>
            <begin position="577"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="845" mass="95307" checksum="FC7617CD8BB638DD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVD9</accession>
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        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10 11" type="ordered locus">CAGL0E02673g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
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                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
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                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
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        <property type="protein sequence ID" value="CAG58724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG3164">
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        <property type="component" value="Chromosome E"/>
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    <dbReference type="GO" id="GO:0032040">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="248"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0128912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="263" mass="30448" checksum="2A0916A504E63CF6" modified="2004-07-19" version="1">MRQKRAKSYRKQLLVYNHTFKFREPYQVLLDDQIVMDSTTSKYDLVKALKRTLQAEVKPMITQCCMQALYETKNEHAIDLGKEFERRRCGHMPGEAVSPKECILNVVDVKGKNKHRYVVACQDVEIRRLLRKVPGVPLLHISRSVMIMEPLSDASAKVSRMEEESKLFRGLNDPKYAGLKGEHEEEEQSKEQTVAKKRKIGPKQPNPLSMKKKKKENTKKEQQTETSADQSQPTKRRRSRKHKHGSKNSTDTNENGNLSEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVX6</accession>
    <name>Q6FVX6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0D04752g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445618.1">
        <property type="nucleotide sequence ID" value="XM_445618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVX6"/>
    <dbReference type="FunCoup" id="Q6FVX6">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVX6"/>
    <dbReference type="KEGG" id="cgr:2887110"/>
    <dbReference type="CGD" id="CAL0128377">
        <property type="gene designation" value="CAGL0D04752g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D04752g"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FVX6"/>
    <dbReference type="OMA" id="PSVENCV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="352" mass="39221" checksum="0CDD8A6295D31432" modified="2004-07-19" version="1">MSKIQQIRNTIRSIGTGYGLMSLTWKAVPTEQEQAFGAMKKAIDLARASNHIAFFNVGEFYGKDRVNLHLVRDFFKKYPELREHVIISCKGAMDLSDLHAMGKYDDVVKSVEACTEAIGGFIEIFEPARLDMDICKEGEVYPKESIQALKDLCDKGVIGAISLSEVDEKVINAVAADFGEYLACVEVELSLFCDDILHNGVAKACSDHNMAIICYSPLGKGILTGQITKNSDIPDGDFRKMLKSFSDEALQHNQEIVSFIRTEIIEKRPAGKEITLPQVALAWIKHWNGDSSYPNAKFIPIPSGSSAARVAENFDEEKSTISDEEFKKLNKYAFNFKPVGARYEFVSDPTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVY9</accession>
    <name>Q6FVY9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0D04378g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVY9"/>
    <dbReference type="FunCoup" id="Q6FVY9">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVY9"/>
    <dbReference type="KEGG" id="cgr:2886979"/>
    <dbReference type="CGD" id="CAL0128161">
        <property type="gene designation" value="CAGL0D04378g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D04378g"/>
    <dbReference type="eggNOG" id="KOG1620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004422_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVY9"/>
    <dbReference type="OMA" id="RVRIGWQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000829">
        <property type="term" value="F:diphosphoinositol pentakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000827">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010919">
        <property type="term" value="P:regulation of inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="729"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0128161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1053" mass="121187" checksum="7932BE4973C1CE06" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW23</accession>
    <name>Q6FW23_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ACP1</name>
        <name evidence="16 17" type="ordered locus">CAGL0D03586g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445571.1">
        <property type="nucleotide sequence ID" value="XM_445571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW23"/>
    <dbReference type="FunCoup" id="Q6FW23">
        <property type="interactions" value="803"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW23"/>
    <dbReference type="GeneID" id="2887165"/>
    <dbReference type="KEGG" id="cgr:2887165"/>
    <dbReference type="CGD" id="CAL0128107">
        <property type="gene designation" value="ACP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03586g"/>
    <dbReference type="eggNOG" id="KOG1748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW23"/>
    <dbReference type="OMA" id="RFKTPRD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0128107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG58482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="116" mass="13206" checksum="FC9D2BBA62860D46" modified="2004-07-19" version="1">MLRTVVNVARQRPMMMAKANMQMLRPVRFYSQGLSKDVVQKRVVDVIKAFDKTSASANITEDTLFHKDLKLDSLDTVELLVAIEEEFDVEFPDKVADELKSVKETVDYILSNPDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW87</accession>
    <name>Q6FW87_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0D02134g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW87"/>
    <dbReference type="STRING" id="284593.Q6FW87"/>
    <dbReference type="KEGG" id="cgr:2887057"/>
    <dbReference type="CGD" id="CAL0128235">
        <property type="gene designation" value="CAGL0D02134g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02134g"/>
    <dbReference type="eggNOG" id="ENOG502QU02">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039436_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW87"/>
    <dbReference type="OMA" id="VAMESEM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24145">
        <property type="entry name" value="Mgr3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53981" checksum="9E09DCF8E88CC83A" modified="2004-07-19" version="1">MLRRVILVSRFGVRSFGQSSRWRQISASANRAYSVENGIDEAPQSDKSGRYSRLAMRVVGAAVIGVGLWWFYWPHHTFPSSVATILRKGLWQETEKFGKNYHRGLQYYRDALKECDKLGVDPLSDEYTGIEIKIAEMHERLDDLENACEIYDHIMQKYLDYLLTTSVSDLDKVGRYIKRDLSVLIKYLQHRDDKYLGKTMLLHHLRVLQNVIYTRYPEISEFLQEQQAVLDTVVKPTSEHRPFEFIDLADGSQTAIGKKLSGEMLDDVVGLFKDELFTALDLFTQYCLQSNDVPAALRNQLMTVQLMSLANVKKSQILFSQANLGSILYLQAEKIEGVLYKLEKEKSSLENEVATDTSKDNEENYYLNLLHSNHDRYVKLSLQCFQGVLNSAEITDNFEEMLDPLSMKAAALAVYGIGVWNIHEGNLKKARKLLKESAKFAKETSFDSLLKEAEKELRKVRKMIKQEKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWG8</accession>
    <name>Q6FWG8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Beta-mannosyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BMT1</name>
        <name evidence="8 9" type="ordered locus">CAGL0D00286g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BMT family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445426.1">
        <property type="nucleotide sequence ID" value="XM_445426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWG8"/>
    <dbReference type="STRING" id="284593.Q6FWG8"/>
    <dbReference type="CAZy" id="GT91">
        <property type="family name" value="Glycosyltransferase Family 91"/>
    </dbReference>
    <dbReference type="GeneID" id="2887196"/>
    <dbReference type="KEGG" id="cgr:2887196"/>
    <dbReference type="CGD" id="CAL0128063">
        <property type="gene designation" value="BMT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00286g"/>
    <dbReference type="eggNOG" id="ENOG502QTZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013841_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWG8"/>
    <dbReference type="OMA" id="DRCTEYL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021988">
        <property type="entry name" value="BMT1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12141">
        <property type="entry name" value="BMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0128063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="733" mass="83978" checksum="CDF45A0DE7A105EB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWR7</accession>
    <name>Q6FWR7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0C03465g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWR7"/>
    <dbReference type="FunCoup" id="Q6FWR7">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWR7"/>
    <dbReference type="KEGG" id="cgr:2886727"/>
    <dbReference type="CGD" id="CAL0127502">
        <property type="gene designation" value="CAGL0C03465g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03465g"/>
    <dbReference type="eggNOG" id="ENOG502S4R3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082503_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWR7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033101">
        <property type="term" value="C:cellular bud membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059107">
        <property type="entry name" value="Mso1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14477">
        <property type="entry name" value="Mso1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mso1 N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Mso1 membrane-polarising" evidence="3">
        <location>
            <begin position="150"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0127502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="207" mass="22816" checksum="E52655AEBBFA41B1" modified="2004-07-19" version="1">MSASSEHGSTRMWDKFKTSTKSLSSSLSQLSIKPETDGSTPTSTVVHKALVKFYKHQEPFQGFPGWLGHKEDLPDEQKILKKQQNHQSKSSRTGDSITSKFDSLRGGFSEKREERPDAASQRTTAGMSFHSIYDKPTSSTDLSSMASPSVRSPLRARSTWSSEADSAKISSAGTNSTAESNNGSAMDPQNMMRARLLRRNTRPLNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWU2</accession>
    <name>Q6FWU2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentamidine resistance factor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0C02871g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWU2"/>
    <dbReference type="FunCoup" id="Q6FWU2">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWU2"/>
    <dbReference type="KEGG" id="cgr:2886864"/>
    <dbReference type="CGD" id="CAL0127456">
        <property type="gene designation" value="CAGL0C02871g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02871g"/>
    <dbReference type="eggNOG" id="ENOG502S645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061833_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWU2"/>
    <dbReference type="OMA" id="EKWGVNN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0127456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="44855" checksum="CB626FE4640359B5" modified="2004-07-19" version="1">MQIAARNNLLWIATRHSSNTVQANRLFELYKNGKLQVVTSHTKIQDDFNSTRSLPMVEFPKNRIFTEVENDTKVGNWRKPITKYYRLGISLLKFYRDGIQNTYAVYRDSRRFLKGFGSQNYKDAIPSMLRIIESQELQLKRNVLTNNTNDLAFKRADLVEMMRRNEIYKLPNFFIICLVFEELTAVLCYFFPQVAPRNCMTPGGYFKISNKKIEQFKKLTREVITDSEQYLPPYALSNSQIYGIIKNSEMPISRGKLYLRNMFNIKDKLIQDLTIWYQYIYIDDWYLVTTLLKGKELRLDRSELVNCIYERKLYQKGENLNEMMLSKEGTDTLVRRLIDYWSYRFGNTIIIDGKLTFNEKWGITNLKSMLPENTLTIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX88</accession>
    <name>Q6FX88_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein STE50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">STE50</name>
        <name evidence="4 5" type="ordered locus">CAGL0B00858g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445008.1">
        <property type="nucleotide sequence ID" value="XM_445008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX88"/>
    <dbReference type="FunCoup" id="Q6FX88">
        <property type="interactions" value="126"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX88"/>
    <dbReference type="GeneID" id="2886618"/>
    <dbReference type="KEGG" id="cgr:2886618"/>
    <dbReference type="CGD" id="CAL0127758">
        <property type="gene designation" value="STE50"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B00858g"/>
    <dbReference type="eggNOG" id="ENOG502RXZB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051042_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX88"/>
    <dbReference type="OMA" id="QDWRQYV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032093">
        <property type="term" value="F:SAM domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09536">
        <property type="entry name" value="SAM_Ste50_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015316">
        <property type="entry name" value="SAM_Ste50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09235">
        <property type="entry name" value="SAM_Ste50p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="216"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0127758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG57908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36403" checksum="439ECFDD529FB462" modified="2004-07-19" version="1">MDDSQKTLRQGTLLKDNFDKWTTDEVVQWCGTVLGKDEQEPLFTRIRDNNIDGSVLQELTLQDCKELTDNDLKEAIKLKLWLNKLIDSQLGEDDVPTEDIVVVLKNLHTTVSQKLLDFQSQYSGLRADVVEIMKRSKTAEHGMSSPQLTPSTASSKPSGARTDYFDHGQLRQSPRAKEVRPTLLYNKSTPNSNSNSNSKYHDQIIHANSSLTIPNIKSNLSPIEPLKQLKASKEDSCEKILKNAMVRHNLADQDWKQYVLVISYGDQERILDLAEKPVVIFKNLKRQGLHPSIMLRRRGDFEEVDMSMNGLSSADVTPGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXB2</accession>
    <name>Q6FXB2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-decapping enzyme subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0B01331g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXB2"/>
    <dbReference type="SMR" id="Q6FXB2"/>
    <dbReference type="FunCoup" id="Q6FXB2">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXB2"/>
    <dbReference type="KEGG" id="cgr:2886678"/>
    <dbReference type="CGD" id="CAL0127846">
        <property type="gene designation" value="CAGL0B01331g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01331g"/>
    <dbReference type="eggNOG" id="KOG2868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113008_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXB2"/>
    <dbReference type="OMA" id="IWIHTVA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098562">
        <property type="term" value="C:cytoplasmic side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098745">
        <property type="term" value="C:RNA decapping complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09804">
        <property type="entry name" value="Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0127846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG57927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23610" checksum="EB7405BA0F3B99BD" modified="2004-07-19" version="1">MSVSNGNDDAEQALEFYRKALNFNVIGRYDPKIKQLLFHTPHASVYKWDIERDEWAKLEYQGVLAIYLRDIGNGQDFLPPQDSTMDASVLAGSMTQGNENYGQGLMLSGRDIYNYGLIILNRLNPDNFSMGIVPNNVVNKRKVFDSIEDAENPLECMGVEVKDELVIIKNLKHEVYGIWIHTVEDRKNVYELIKYLLENEPKTSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXE6</accession>
    <name>Q6FXE6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0B02541g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXE6"/>
    <dbReference type="FunCoup" id="Q6FXE6">
        <property type="interactions" value="349"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXE6"/>
    <dbReference type="KEGG" id="cgr:2886558"/>
    <dbReference type="CGD" id="CAL0127106">
        <property type="gene designation" value="CAGL0B02541g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B02541g"/>
    <dbReference type="eggNOG" id="ENOG502QVTM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026029_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXE6"/>
    <dbReference type="OMA" id="KRFVIKG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009303">
        <property type="term" value="P:rRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="5">
        <location>
            <begin position="403"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0127106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG57981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="588" mass="67146" checksum="A2E28236B55C39ED" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXF1</accession>
    <name>Q6FXF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="3">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0B02431g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="3"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXF1"/>
    <dbReference type="FunCoup" id="Q6FXF1">
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</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
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                <person name="Jauniaux N."/>
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                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
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                <person name="Swennene D."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXF4</accession>
    <name>Q6FXF4_CANGA</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="5 6" type="ordered locus">CAGL0B02365g</name>
    </gene>
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        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
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                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
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                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
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                <person name="Fabre E."/>
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                <person name="Jauniaux N."/>
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                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
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                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
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                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
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                <person name="Swennene D."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
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                <person name="Scarpelli C."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="entry name" value="Cwc2/Slt11"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018835">
        <property type="entry name" value="RNA-binding_domain_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF10">
        <property type="entry name" value="RNA-BINDING PROTEIN NAB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10567">
        <property type="entry name" value="Nab6_mRNP_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10378">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="604"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="862"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="928"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0127696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG57973.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117903" checksum="FBA353522509D38A" modified="2008-09-23" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXP1</accession>
    <name>Q6FXP1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SCP120</name>
        <name evidence="3 4" type="ordered locus">CAGL0B04235g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445154.1">
        <property type="nucleotide sequence ID" value="XM_445154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXP1"/>
    <dbReference type="GeneID" id="2886581"/>
    <dbReference type="KEGG" id="cgr:2886581"/>
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        <property type="gene designation" value="SCP120"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04235g"/>
    <dbReference type="HOGENOM" id="CLU_888514_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXP1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274285" evidence="2">
        <location>
            <begin position="22"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="313" mass="35630" checksum="231A11CC8AA5C631" modified="2004-07-19" version="1">MNSKIVSTLVILLLILFSCNATLITDEAAKLRVVSRIEGAIATSWMDKAKLKLSIITGKHANFRSDLPIETVQPNYLQYLVNSISNMHEVNLVLLLPELEDYNDSDIWKIRDSLEDFIKGAQNLTEKLDNASWMRKKLYASTVRANTIFYLRHLLFRSSFLSYMTQKGNEDPNLMLTELIQIIEESKVTLLTAIKIIAIFETNNFESLLGILPTINNNDSTEQALVVNQLGYELCPECEKQRREEMETEHLWQDAYIKTMALLLGRTAAFVVFCTAIGAYSCTAALLVFGCKAYIIWTQIWIDSIKLSLGKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXR0</accession>
    <name>Q6FXR0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SUI2</name>
        <name evidence="12 13" type="ordered locus">CAGL0B03795g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXR0"/>
    <dbReference type="FunCoup" id="Q6FXR0">
        <property type="interactions" value="1418"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXR0"/>
    <dbReference type="KEGG" id="cgr:2886561"/>
    <dbReference type="CGD" id="CAL0127098">
        <property type="gene designation" value="SUI2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03795g"/>
    <dbReference type="eggNOG" id="KOG2916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033458_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FXR0"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990856">
        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1130:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.190:FF:000002">
        <property type="entry name" value="Translation initiation factor 2, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0127098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="303" mass="34572" checksum="7AF4834D0899CACE" modified="2004-07-19" version="1">MSINHCRFYENKYPDVDDVVMVNVQQIAEMGAYVKLLEYDNIEGMILLSELSRRRIRSIQKLIRVGKNDVAVVLRVDKEKGYIDLSKRRVSSEDIIKCEEKYQKSKTVHSILRYCAEKFQIPLEDLYKTIAWPLSRKFGHAYEAFKLSIIDETVWEGIEPPSQDILNELKTYISKRLTPQAVKIRADVEVSCFSYEGIDAIKEALKSAEDMSTEQMQIKVKLVAAPLYVLTTQALDKQIGIDLLGKAIDKINEVISKYGGVCNITMPPKAVTATEDAELQALLESKEQDNRSDSEDEDNSDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXU9</accession>
    <name>Q6FXU9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SCL1</name>
        <name evidence="9 10" type="ordered locus">CAGL0A00407g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444790.1">
        <property type="nucleotide sequence ID" value="XM_444790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXU9"/>
    <dbReference type="FunCoup" id="Q6FXU9">
        <property type="interactions" value="1146"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXU9"/>
    <dbReference type="MEROPS" id="T01.971"/>
    <dbReference type="GeneID" id="2886460"/>
    <dbReference type="KEGG" id="cgr:2886460"/>
    <dbReference type="CGD" id="CAL0126727">
        <property type="gene designation" value="SCL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A00407g"/>
    <dbReference type="eggNOG" id="KOG0182">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FXU9"/>
    <dbReference type="OMA" id="YGYDMPV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0126727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG57681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="254" mass="28141" checksum="89728747C167B70B" modified="2004-07-19" version="1">MSGGAAAASAAGYDRHITIFSPEGRLYQVEYAFKATNQTNLNSLAVRGKNCSVIINQKKVPDKLLDPSTVSYIFKISKTIGMVANGPIPDARNAAARAKGEAAEFRYKYGYDMPCDVLAKRMANLSQIYTQRAYMRPLGVILTFISVDEELGPSIYKCDPAGYYVGYKATATGPKQQELTTSLENYYKKKNVGSHLDMEEWEKVVEFGITQMIDSLGTEFSKKDLEIGVATENKFIILTPDEIEERLVAIAEQD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FYA6</accession>
    <name>MUS81_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Crossover junction endonuclease MUS81</fullName>
            <ecNumber>3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MUS81</name>
        <name type="ordered locus">CAGL0A03256g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444909.1">
        <property type="nucleotide sequence ID" value="XM_444909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FYA6"/>
    <dbReference type="SMR" id="Q6FYA6"/>
    <dbReference type="FunCoup" id="Q6FYA6">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FYA6"/>
    <dbReference type="EnsemblFungi" id="CAGL0A03256g-T">
        <property type="protein sequence ID" value="CAGL0A03256g-T-p1"/>
        <property type="gene ID" value="CAGL0A03256g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886325"/>
    <dbReference type="KEGG" id="cgr:2886325"/>
    <dbReference type="CGD" id="CAL0126939">
        <property type="gene designation" value="CAGL0A03256g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A03256g"/>
    <dbReference type="eggNOG" id="KOG2379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014329_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FYA6"/>
    <dbReference type="OMA" id="ELGDAMW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21036">
        <property type="entry name" value="WH_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000307">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000011">
        <property type="entry name" value="Crossover junction endonuclease MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047417">
        <property type="entry name" value="WHD_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21136">
        <property type="entry name" value="WHD_MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223703" description="Crossover junction endonuclease MUS81">
        <location>
            <begin position="1"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="ERCC4">
        <location>
            <begin position="348"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="628" mass="72027" checksum="D50C41E10BB70DC1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2025-06-18" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q86Z42</accession>
    <accession>Q6FXB4</accession>
    <accession>Q870I6</accession>
    <name>MTAL2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mating-type-like protein ALPHA2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>MTL1alpha2 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MTL1ALPHA2</name>
        <name type="synonym">ALPHA2</name>
        <name type="ordered locus">CAGL0B01265g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Genome Biol." volume="4" first="R10.1" last="R10.9">
            <title>Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata.</title>
            <authorList>
                <person name="Wong S."/>
                <person name="Fares M.A."/>
                <person name="Zimmermann W."/>
                <person name="Butler G."/>
                <person name="Wolfe K.H."/>
            </authorList>
            <dbReference type="PubMed" id="12620120"/>
            <dbReference type="DOI" id="10.1186/gb-2003-4-2-r10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Eukaryot. Cell" volume="2" first="328" last="340">
            <title>Three mating type-like loci in Candida glabrata.</title>
            <authorList>
                <person name="Srikantha T."/>
                <person name="Lachke S.A."/>
                <person name="Soll D.R."/>
            </authorList>
            <dbReference type="PubMed" id="12684382"/>
            <dbReference type="DOI" id="10.1128/EC.2.2.328-340.2003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>VARIANT PRO-150</scope>
        <source>
            <strain>1480.47</strain>
            <strain>PB921</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Infect. Immun." volume="71" first="7109" last="7118">
            <title>Phenotypic switching and mating type switching of Candida glabrata at sites of colonization.</title>
            <authorList>
                <person name="Brockert P.J."/>
                <person name="Lachke S.A."/>
                <person name="Srikantha T."/>
                <person name="Pujol C."/>
                <person name="Galask R."/>
                <person name="Soll D.R."/>
            </authorList>
            <dbReference type="PubMed" id="14638801"/>
            <dbReference type="DOI" id="10.1128/IAI.71.12.7109-7118.2003"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text>Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="3">Only present in alpha-cells (classes II and III).</text>
    </comment>
    <comment type="miscellaneous">
        <text>There are three genetic loci for mating type genes in C.glabrata. MTL1 seems to be the expression locus that determines the mating type of the cell, whereas MTL2 (containing MTL2A1) and MTL3 (containing MTL3ALPHA1 and MTL3ALPHA2) appear to represent silenced repositories of mating type information. Notably, MTL3ALPHA2 contains a unique stretch coding for 22 amino acids at the C-terminus that is not shared by MTL1ALPHA2.</text>
    </comment>
    <comment type="miscellaneous">
        <text>Haploid C.glabrata strains can switch mating type, however, neither mating nor diploid forms of C.glabrata have been observed so far.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TALE/M-ATYP homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="AY181247">
        <property type="protein sequence ID" value="AAO25592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY191463">
        <property type="protein sequence ID" value="AAP06782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY191464">
        <property type="protein sequence ID" value="AAP06784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q86Z42"/>
    <dbReference type="SMR" id="Q86Z42"/>
    <dbReference type="FunCoup" id="Q86Z42">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q86Z42"/>
    <dbReference type="EnsemblFungi" id="CAGL0B01265g-T">
        <property type="protein sequence ID" value="CAGL0B01265g-T-p1"/>
        <property type="gene ID" value="CAGL0B01265g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886680"/>
    <dbReference type="CGD" id="CAL0127104">
        <property type="gene designation" value="MATalpha2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01265g"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091806_1_0_1"/>
    <dbReference type="InParanoid" id="Q86Z42"/>
    <dbReference type="OMA" id="KVQIKNW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000049175" description="Mating-type-like protein ALPHA2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox; TALE-type" evidence="1">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In strain: PB921." evidence="2">
        <original>L</original>
        <variation>P</variation>
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="12684382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="14638801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="186" mass="21816" checksum="BC606BB35753A42D" modified="2003-06-01" version="1">MSKKSRISITHLLNPIQEENLKEKLQEINNQLISLCSSLPKRQSLPGPSSDILRFLSRNNLDPQEIGLIKTTYRLSTLLSKLREHEIVFNVVTKDHLLKKGVPNHYAASYRGHRFTRENVQILETWYRNHIDNPYLDHNSQQYLAQKTNLSKIQIKNWVANRRRKQKSIYISPFRPTLMAQNSLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>B4UMX4</accession>
    <name>B4UMX4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0B01589g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAR57998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UMX4"/>
    <dbReference type="FunCoup" id="B4UMX4">
        <property type="interactions" value="236"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UMX4"/>
    <dbReference type="KEGG" id="cgr:9487962"/>
    <dbReference type="CGD" id="CAL0127074">
        <property type="gene designation" value="CAGL0B01589g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01589g"/>
    <dbReference type="eggNOG" id="KOG0001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_6_4_1"/>
    <dbReference type="InParanoid" id="B4UMX4"/>
    <dbReference type="OMA" id="YAGKQMA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAR57998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="77" mass="8568" checksum="9ECBFBCFF146D3EA" modified="2008-09-23" version="1">MIIKVKTLTGKEIPVEVSGEDKVYHIKELLEEKEGIPASQQRLIFHGKQINNDDTISTAKLSDGMQLHLVLTLRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>B4UMY2</accession>
    <name>B4UMY2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MFA2</name>
        <name evidence="1 2" type="ordered locus">CAGL0C01919g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAR58006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002999523.1">
        <property type="nucleotide sequence ID" value="XM_002999477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UMY2"/>
    <dbReference type="FunCoup" id="B4UMY2">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UMY2"/>
    <dbReference type="GeneID" id="9487971"/>
    <dbReference type="KEGG" id="cgr:9487971"/>
    <dbReference type="CGD" id="CAL0127558">
        <property type="gene designation" value="MFA2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C01919g"/>
    <dbReference type="eggNOG" id="ENOG502SCDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_220658_0_0_1"/>
    <dbReference type="InParanoid" id="B4UMY2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000772">
        <property type="term" value="F:mating pheromone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035296">
        <property type="entry name" value="Mfa1/2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17317">
        <property type="entry name" value="MFA1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0127558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR58006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="34" mass="3974" checksum="F3BE970FFE47CC26" modified="2008-09-23" version="1">MQPTIEATQKDNTQEKRDNYIVKGFFWSPDCVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN61</accession>
    <name>B4UN61_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0M10235g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAR58077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN61"/>
    <dbReference type="FunCoup" id="B4UN61">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UN61"/>
    <dbReference type="KEGG" id="cgr:9488060"/>
    <dbReference type="CGD" id="CAL0137137">
        <property type="gene designation" value="CAGL0M10235g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M10235g"/>
    <dbReference type="eggNOG" id="ENOG502S4UD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150783_1_0_1"/>
    <dbReference type="InParanoid" id="B4UN61"/>
    <dbReference type="OMA" id="NIWRMVG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="3"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0137137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAR58077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="93" mass="10649" checksum="E5DD55894EFECEBA" modified="2008-09-23" version="1">MSRYQEADNDKKLESLATKLSTFRNINEDIGRQAQIDSSVIDSISESFSSLLNDLKNSSSRLTRSMSMGSGVWRMVFIALSVFFIIYTLYKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FII8</accession>
    <name>Q6FII8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PWP6</name>
        <name evidence="4 5" type="ordered locus">CAGL0M14069g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449956.1">
        <property type="nucleotide sequence ID" value="XM_449956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FII8"/>
    <dbReference type="STRING" id="284593.Q6FII8"/>
    <dbReference type="GeneID" id="2891618"/>
    <dbReference type="KEGG" id="cgr:2891618"/>
    <dbReference type="CGD" id="CAL0137423">
        <property type="gene designation" value="PWP6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M14069g"/>
    <dbReference type="HOGENOM" id="CLU_006076_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FII8"/>
    <dbReference type="OMA" id="FTNSQDY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273993" description="PA14 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="55"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0137423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="866" mass="93636" checksum="2D07F4EC2A79662E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ73</accession>
    <name>CIAO1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CIA1</name>
        <name type="ordered locus">CAGL0M08646g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with NAR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Preferentially localized to the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449721.1">
        <property type="nucleotide sequence ID" value="XM_449721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ73"/>
    <dbReference type="SMR" id="Q6FJ73"/>
    <dbReference type="FunCoup" id="Q6FJ73">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ73"/>
    <dbReference type="EnsemblFungi" id="CAGL0M08646g-T">
        <property type="protein sequence ID" value="CAGL0M08646g-T-p1"/>
        <property type="gene ID" value="CAGL0M08646g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891282"/>
    <dbReference type="KEGG" id="cgr:2891282"/>
    <dbReference type="CGD" id="CAL0136897">
        <property type="gene designation" value="CAGL0M08646g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M08646g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08646g"/>
    <dbReference type="eggNOG" id="KOG0645">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_8_1"/>
    <dbReference type="InParanoid" id="Q6FJ73"/>
    <dbReference type="OMA" id="MPILASC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000705">
        <property type="entry name" value="Probable cytosolic iron-sulfur protein assembly protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000382510" description="Probable cytosolic iron-sulfur protein assembly protein 1">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="109"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="199"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="301"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <sequence length="337" mass="38019" checksum="E6767EE6E9C3DD7E" modified="2004-07-19" version="1">MPLQLAKSLKLHNDKVWSIDFEPVRGLLATGSTDRAIKVLQLKNGKENLLDVLDDTVHKKAVRSVAWRPHSDLLAAGSFDSTISIWTQSDLDLEEGAKLEMELLAIIEGHENEVKGISWSQDGCLLATCSRDKSVWIWETDEAGEEYECISVLQEHSQDVKHVVWHTKHNLLASSSYDDTVRIWKDYDDDWECAAVLTGHEGTIWCSDFSKEEDPIRLCSGSDDSTVRVWKYIGDDEDDQQEWVCESTLPNAHRSQIYGVAWSPSGRIASVGADGVLAVYKEKQNDSEVSEWEISATYKAAHTVYEINTVKWVNIDGKEMLITAGDDGRVNLWNYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJM8</accession>
    <name>Q6FJM8_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M05027g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJM8"/>
    <dbReference type="FunCoup" id="Q6FJM8">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJM8"/>
    <dbReference type="KEGG" id="cgr:2891576"/>
    <dbReference type="CGD" id="CAL0136589">
        <property type="gene designation" value="CAGL0M05027g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05027g"/>
    <dbReference type="eggNOG" id="ENOG502QSKI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019711_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJM8"/>
    <dbReference type="OMA" id="IEAYQHC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0136589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="742" mass="83072" checksum="E6DA3BEBC072135C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJP1</accession>
    <name>RRP36_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Ribosomal RNA-processing protein 36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RRP36</name>
        <name type="ordered locus">CAGL0M04719g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RRP36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449553.1">
        <property type="nucleotide sequence ID" value="XM_449553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJP1"/>
    <dbReference type="SMR" id="Q6FJP1"/>
    <dbReference type="FunCoup" id="Q6FJP1">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJP1"/>
    <dbReference type="EnsemblFungi" id="CAGL0M04719g-T">
        <property type="protein sequence ID" value="CAGL0M04719g-T-p1"/>
        <property type="gene ID" value="CAGL0M04719g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891562"/>
    <dbReference type="KEGG" id="cgr:2891562"/>
    <dbReference type="CGD" id="CAL0136679">
        <property type="gene designation" value="CAGL0M04719g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04719g"/>
    <dbReference type="eggNOG" id="KOG3190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048802_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FJP1"/>
    <dbReference type="OMA" id="ERKEMPW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000397625" description="rRNA biogenesis protein RRP36">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="188"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="313" mass="37332" checksum="282F9C1F16CA6476" modified="2004-07-19" version="1">MSYYFKNIKPSYDDDSDEVSDEQDLDAILASKMRGRAESDDESSEEEDDGLSKLSFGSLKKAEDQLEEEERGELRKKRKPQHSKPINDEPEVRHKVYKEEEQEESDSESGSDDGAFFEEDERDNHSRPKNKNSKKRKHAPTEHSSKKRVSKIRDIPGLEIARQAKSGIYQDVRFTKATGEATDFSVIRRRYKFLDEYREKEIEEMERLLNDKKFVNKAESREIENMKEKVRSMKSRLQSVKNRELEQQIVKDYEGKLNEGNKNRFHLKKAEKRKVIQKWKFDHMKAKQREKVMERKRKKKLGKEFKQFEFHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJY6</accession>
    <name>Q6FJY6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional regulatory protein UME1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M02563g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJY6"/>
    <dbReference type="FunCoup" id="Q6FJY6">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJY6"/>
    <dbReference type="KEGG" id="cgr:2891466"/>
    <dbReference type="CGD" id="CAL0137133">
        <property type="gene designation" value="CAGL0M02563g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02563g"/>
    <dbReference type="eggNOG" id="ENOG502QSEV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036523_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJY6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016479">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040020">
        <property type="term" value="P:regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50752" checksum="87006D6AB532CF24" modified="2004-07-19" version="1">MTVDTEIASNKLRNEEFKIWKKTIPLLYQHISTMKPKYANASKGTIKDVPCCLTFSDEVIPNKANGTLSTVIYYGIGNEIYSLDCDLPLGLHLQKDTLQPNEKLQLPQFDQIVSRIQSEDLSPKWRAAANCNIYKIKCVGNGKVVALLDSGAIVWFQESTESPVSMVDGGAKIIPNKYELEEDFVNDSLNKIDFDFDLSLNGEKIIVSQAVLNEDRTVIKVFSNIDKDLGKLLISLDLPGTKSVHNIKFYNDNIFGFCDNSGNLYFYDSRNLATPIWKIENEHILSFAFSPLVETLLITGGANGIINFWDVKRLTVKTATTGGDKRQESLLSLSNHVEEPISSVEFSASSPSEFITVGISGSIYHWDVFNYFEKVSELFSEGGDQSAIDSLDTEEIQAESLTFYHTGGSRRHLGKSTKKNSVSVHPIIEGLIGTIDTDGLITVYKPFTGVLPEAEDS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-24" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK63</accession>
    <name>RS3A_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">40S ribosomal protein S1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">RPS1</name>
        <name type="ordered locus">CAGL0M00814g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK63"/>
    <dbReference type="SMR" id="Q6FK63"/>
    <dbReference type="FunCoup" id="Q6FK63">
        <property type="interactions" value="1500"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK63"/>
    <dbReference type="EnsemblFungi" id="CAGL0M00814g-T">
        <property type="protein sequence ID" value="CAGL0M00814g-T-p1"/>
        <property type="gene ID" value="CAGL0M00814g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891604"/>
    <dbReference type="CGD" id="CAL0137117">
        <property type="gene designation" value="CAGL0M00814g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M00814g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00814g"/>
    <dbReference type="eggNOG" id="KOG1628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062507_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK63"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000389365" description="Small ribosomal subunit protein eS1">
        <location>
            <begin position="2"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="1">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="255" mass="28730" checksum="9144D5EBF7C20344" modified="2004-07-19" version="1">MAVGKNKRLSKGKKGLKKKVVDPFTRKEWYDIKAPSTFENRNVGKTLVNKSTGLKSASDALKGRVVEVCLADLQGSEDHSFRKVKLRVDDVQGKNLLTNFHGMDFTADKLRSMVRKWQTLIEANVTVKTSDEYIIRVFAIAFTRKQSNQVKRTAYAQSSHIRAIRKVISDILTREVSNSTLAQFTSKLIPEVINKEIENATKDIFPLQNVHIRKVKLLKQPKFDLGSLMALHGEGSAEEKGKKVSGFKDEVLETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK64</accession>
    <name>Q6FK64_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M00792g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449380.1">
        <property type="nucleotide sequence ID" value="XM_449380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK64"/>
    <dbReference type="KEGG" id="cgr:2891603"/>
    <dbReference type="CGD" id="CAL0136377">
        <property type="gene designation" value="CAGL0M00792g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00792g"/>
    <dbReference type="HOGENOM" id="CLU_2305732_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK64"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="100" mass="11207" checksum="F2F556A4F194E9D4" modified="2004-07-19" version="1">MSSQAFALCRKRFFHCLSQLRCTIFQNLTACGSVGPRRSSGNPGSLPSWDGHCSQWLPQDHRWGPLPSEPKTMPRFEPNLSLTSAWPQPKLSPGSKVRLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-24" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK91</accession>
    <name>MG101_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MGM101</name>
        <name type="ordered locus">CAGL0M00198g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MGM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449353.1">
        <property type="nucleotide sequence ID" value="XM_449353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK91"/>
    <dbReference type="FunCoup" id="Q6FK91">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK91"/>
    <dbReference type="EnsemblFungi" id="CAGL0M00198g-T">
        <property type="protein sequence ID" value="CAGL0M00198g-T-p1"/>
        <property type="gene ID" value="CAGL0M00198g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891149"/>
    <dbReference type="KEGG" id="cgr:2891149"/>
    <dbReference type="CGD" id="CAL0136347">
        <property type="gene designation" value="CAGL0M00198g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00198g"/>
    <dbReference type="eggNOG" id="ENOG502RXU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028692_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FK91"/>
    <dbReference type="OMA" id="INWETSW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000045816" description="Mitochondrial genome maintenance protein MGM101">
        <location>
            <begin position="23"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="244" mass="27144" checksum="4C51629D651556BB" modified="2004-07-19" version="1" precursor="true">MQRLLKFSGHGSRALFLARRWNSNIASGTAGTFQTTAKPLRSVKPTEAALALNGKFLESTNGNENGITSMGSIDWYTSWHGLGSKPFDATVQKALALPLEPTDIEIKPDGLIYLPEIKYRRILNRAFGAGGWGLVPRSQTIVTSKLVTREYGLVCHGQLVSVSRGEQDYFSETGIPTATEGCKSNALMRCCKDLGIGSELWDPVFIKRFKTEHCVEKFVTHIATSKKKKIWIRKDRSVEYPYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKJ0</accession>
    <name>Q6FKJ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0L11176g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKJ0"/>
    <dbReference type="FunCoup" id="Q6FKJ0">
        <property type="interactions" value="647"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKJ0"/>
    <dbReference type="KEGG" id="cgr:2891029"/>
    <dbReference type="CGD" id="CAL0136150">
        <property type="gene designation" value="CAGL0L11176g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11176g"/>
    <dbReference type="eggNOG" id="KOG2875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027543_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FKJ0"/>
    <dbReference type="OMA" id="ITKMCHS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="11">
        <location>
            <begin position="130"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0136150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG62228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="366" mass="41590" checksum="F1CC9883C5E6FFE4" modified="2004-07-19" version="1">MSINGLLNVSAGELCLKNVLQTGQSFRWLLDEATGIYSTTLKISDTLGYSIITLRQDVDFGQVFYEVLNAKVDTETIENHLKNYFRLDVDLQNLHKNHWLANDEKFKMLDHKGIRILGQEPWETLVSFICSTNNNIGRISKMCHALSENFGEYIDEYKGTKYYTFPSSEDIATKATEIQLRGLGFGYRAKYIIETAKKFVEDKKKYGLSDDAQFLNEVVAKKGYLEAREFLMGYCGVGPKVADCVCLMGLHMDEVVPVDVHVGRIAKRDYNIQAPKKFLQELRGQFDHLPITKKKINPELDYIRLKFTEIWGEYAGWAQGLLFFRETDKSDASAAKKRKTTSSPAASKKPKLDTNELVSAISVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKM6</accession>
    <name>Q6FKM6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0L10384g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKM6"/>
    <dbReference type="FunCoup" id="Q6FKM6">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKM6"/>
    <dbReference type="KEGG" id="cgr:2891069"/>
    <dbReference type="CGD" id="CAL0135182">
        <property type="gene designation" value="CAGL0L10384g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10384g"/>
    <dbReference type="eggNOG" id="KOG1973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074406_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKM6"/>
    <dbReference type="OMA" id="PCDIVRS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF103">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="11">
        <location>
            <begin position="169"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="9">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="9">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="9">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="9">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0135182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG62192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="221" mass="25916" checksum="5ABB2F9706D95431" modified="2004-07-19" version="1">MESRIVSSAEQATDIRYSFLNTLDHFSCEYVRTLWLIQYLDNKCLDGARDEEALELQICGKAEYLNKLVEERVSFLQQYKQDLEMQKGINKRYSQLLSRKKGTSTVVRQSSKTTTKKQNGKKLLLKINLKKAYRRDMELEKKRKDYLQKSSNESKKREVKDANGDEERYCFCNDVSYGAMIACDNSKCEREWFHYPCIGMTKPPSGKWYCSEKCRLQGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKT2</accession>
    <name>Q6FKT2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0L08888g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
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                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
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                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
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        <property type="protein sequence ID" value="CAG62132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="284593.Q6FKT2"/>
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        <property type="gene designation" value="CAGL0L08888g"/>
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    <dbReference type="eggNOG" id="KOG1933">
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        <property type="component" value="Chromosome L"/>
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        <property type="term" value="C:fungal-type vacuole membrane"/>
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        <property type="term" value="F:sterol binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:sphingolipid metabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
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    </dbReference>
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        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
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        <property type="entry name" value="NPC1_MLD"/>
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    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
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        <property type="entry name" value="NPC1_MLD"/>
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    </dbReference>
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        <property type="entry name" value="NPC1_N"/>
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    </dbReference>
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        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
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        <location>
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        </location>
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        </location>
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        <location>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
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                <person name="Jauniaux N."/>
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                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
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                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        <subcellularLocation>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL03</accession>
    <name>Q6FL03_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0L07216g</name>
    </gene>
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        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        </lineage>
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    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
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                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
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                <person name="Despons L."/>
                <person name="Fabre E."/>
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                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
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                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449091.1">
        <property type="nucleotide sequence ID" value="XM_449091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL03"/>
    <dbReference type="FunCoup" id="Q6FL03">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL03"/>
    <dbReference type="CAZy" id="GT39">
        <property type="family name" value="Glycosyltransferase Family 39"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890979"/>
    <dbReference type="CGD" id="CAL0136120">
        <property type="gene designation" value="CAGL0L07216g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07216g"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FL03"/>
    <dbReference type="OMA" id="KNVTPRL"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097582">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097583">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900101">
        <property type="term" value="P:regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="598"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="399"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0136120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG62061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="858" mass="96895" checksum="BCCCE3274A69F536" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL27</accession>
    <name>Q6FL27_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L06688g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449067.1">
        <property type="nucleotide sequence ID" value="XM_449067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL27"/>
    <dbReference type="KEGG" id="cgr:2890666"/>
    <dbReference type="CGD" id="CAL0135084">
        <property type="gene designation" value="CAGL0L06688g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06688g"/>
    <dbReference type="HOGENOM" id="CLU_401691_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL27"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="509"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0135084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="685" mass="77635" checksum="70495449241AD4D3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLA8</accession>
    <name>RS23_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein uS12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>40S ribosomal protein S23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPS23</name>
        <name type="ordered locus">CAGL0L04840g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLA8"/>
    <dbReference type="SMR" id="Q6FLA8"/>
    <dbReference type="FunCoup" id="Q6FLA8">
        <property type="interactions" value="908"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLA8"/>
    <dbReference type="EnsemblFungi" id="CAGL0L04840g-T">
        <property type="protein sequence ID" value="CAGL0L04840g-T-p1"/>
        <property type="gene ID" value="CAGL0L04840g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890709"/>
    <dbReference type="CGD" id="CAL0135448">
        <property type="gene designation" value="CAGL0L04840g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L04840g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04840g"/>
    <dbReference type="eggNOG" id="KOG1749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115574_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FLA8"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0379">Hydroxylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000146476" description="Small ribosomal subunit protein uS12">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="modified residue" description="Hydroxyproline" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="145" mass="16038" checksum="5A89ADF540DA1311" modified="2004-07-19" version="1">MGKGKPRGLNSARKLRVHRRNNRWAENNYKKRLLGTAFKSSPFGGSSHAKGIVLEKLGIESKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVSLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLF7</accession>
    <name>Q6FLF7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L03762g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448937.1">
        <property type="nucleotide sequence ID" value="XM_448937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLF7"/>
    <dbReference type="FunCoup" id="Q6FLF7">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890540"/>
    <dbReference type="CGD" id="CAL0136076">
        <property type="gene designation" value="CAGL0L03762g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03762g"/>
    <dbReference type="eggNOG" id="ENOG502SCTI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1749394_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLF7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="149" mass="16968" checksum="CAC48D4E750BA4FA" modified="2004-07-19" version="1">MEKAIPFIRSNQEIEFRVGDRDVYIHLPSFVLGALVIGLVGPILKTVIGGIWVGLILFSKFAVVIGIALTIIWILSGSQKRQVKRSKPTYTETINKIRPQEDSEADIGSYKYFNIPVEKEPYIKRKPSISTISIDEKDLYTNFVRKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLP8</accession>
    <name>Q6FLP8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0L01749g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLP8"/>
    <dbReference type="FunCoup" id="Q6FLP8">
        <property type="interactions" value="980"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLP8"/>
    <dbReference type="KEGG" id="cgr:2890888"/>
    <dbReference type="CGD" id="CAL0136004">
        <property type="gene designation" value="CAGL0L01749g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01749g"/>
    <dbReference type="eggNOG" id="KOG2267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026253_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FLP8"/>
    <dbReference type="OMA" id="RINYKPW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="11">
        <location>
            <begin position="317"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0136004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="502" mass="59510" checksum="24A58BAA302F6EE3" modified="2004-07-19" version="1">MFRQSKKRVSMRRNFAEDRGDASAIIIGATTTEEEKKLYQRIYENKLSFYDIPPQGEITLEEFEIWAIDRLKLLLEIESCLARNKTLKEIEGIIKPLFKKYNIFNNMDTFEDRKKEYYSHFILRLCFCKSKELRDKFVRIETMLLRLRFNMLSSTDQAKFVKSLNLPSLQFIDEEEKAELSTQLYQTISRDLQFTLNLADEQQRQLYFKNEKFIKLPFESVIELVGNRQVFLKNGYAYLPQFQQLNLIANEFSTKLQEELIKTYQYLPRLNEDDRLIPILNHLSSGYTIADSGSFDSQFGNNEDNEINAKSVWSEEISKHYPLSVKNLFYGLKENNHLRYHGRQQLTLFLKGIGLSVDEALKFWHDAFTKNNKMTTEKFNKEYRYNIRHSYGLEGNRINYKPWDCRTILSKPRPNRGEYHGCPFRDWNHDRLTSELSKMGLTTQQITDVLDSCDKHEYTIACTKVFEMTHNVPEGESMHISHPNLYFERSRQLEKKAKGEKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLQ6</accession>
    <name>RSE1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RSE1</name>
        <name type="ordered locus">CAGL0L01507g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448838.1">
        <property type="nucleotide sequence ID" value="XM_448838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLQ6"/>
    <dbReference type="SMR" id="Q6FLQ6"/>
    <dbReference type="FunCoup" id="Q6FLQ6">
        <property type="interactions" value="1429"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLQ6"/>
    <dbReference type="EnsemblFungi" id="CAGL0L01507g-T">
        <property type="protein sequence ID" value="CAGL0L01507g-T-p1"/>
        <property type="gene ID" value="CAGL0L01507g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890878"/>
    <dbReference type="KEGG" id="cgr:2890878"/>
    <dbReference type="CGD" id="CAL0136188">
        <property type="gene designation" value="CAGL0L01507g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01507g"/>
    <dbReference type="eggNOG" id="KOG1898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003246_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLQ6"/>
    <dbReference type="OMA" id="IANDICT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000218628" description="Pre-mRNA-splicing factor RSE1">
        <location>
            <begin position="1"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1296" mass="146718" checksum="9C3CBA77A8359D5E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLU6</accession>
    <name>Q6FLU6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0L00561g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLU6"/>
    <dbReference type="STRING" id="284593.Q6FLU6"/>
    <dbReference type="KEGG" id="cgr:2891106"/>
    <dbReference type="CGD" id="CAL0135106">
        <property type="gene designation" value="CAGL0L00561g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L00561g"/>
    <dbReference type="eggNOG" id="KOG0810">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042423_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FLU6"/>
    <dbReference type="OMA" id="ISETHNM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="5">
        <location>
            <begin position="162"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0135106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="264" mass="30826" checksum="509533039DE86B5B" modified="2004-07-19" version="1">MSQEYQAILSDVQNIQTQLRIYDQLLQNISNLHNVIYSQIDENSEVNKGKLDNLAAEIAKLQQGVANKIKQLSTKIKFHDNEHYVHYSAIRDQFLSLIRKQRLIEYNWKLSCRNEVKRQIDLMSLDLSDAQIDDYLADPENEIYQSIFKRYLLSNEDAKMALNEVEHRMKEIKNLEKRMNDLAILFKEMEELVVQQEEPIDKIDTNVEKVVVDLESGITHTEQAIHIAEQKRKNKKLLISIIFYVCAILLLSIFVAVIVTVSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLZ5</accession>
    <name>Q6FLZ5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inorganic phosphate transport protein PHO88</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PHO88</name>
        <name evidence="3 4" type="ordered locus">CAGL0K12276g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLZ5"/>
    <dbReference type="FunCoup" id="Q6FLZ5">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889978"/>
    <dbReference type="CGD" id="CAL0134391">
        <property type="gene designation" value="PHO88"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12276g"/>
    <dbReference type="eggNOG" id="KOG4554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099163_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLZ5"/>
    <dbReference type="OMA" id="ITYSEYD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0134391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21599" checksum="ACE2CAE8C0E4517A" modified="2004-07-19" version="1">MNPQVSNIIIMLVMMQISRRIDMEDETNILYIRIAYVASIAIAYVVYQYTRSKVVAKNDLTTLKYVEQTSPFSAEALEKSQKEKFNVTTVRDYDLKELDSAIKSIYTGVLMMGFMHFYMGYVNPLFMQSISPVKSALEHNVVKIHLFNKPAVGDLKRPFVAPSLFGGSAKNSTPAEAVEKAEKAGNGGAGIKAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM86</accession>
    <name>TFB5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>General transcription and DNA repair factor IIH subunit TFB5</fullName>
            <shortName>TFIIH subunit TFB5</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>RNA polymerase II transcription factor B subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TFB5</name>
        <name type="ordered locus">CAGL0K10098g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TFB5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448658.1">
        <property type="nucleotide sequence ID" value="XM_448658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM86"/>
    <dbReference type="SMR" id="Q6FM86"/>
    <dbReference type="FunCoup" id="Q6FM86">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM86"/>
    <dbReference type="EnsemblFungi" id="CAGL0K10098g-T">
        <property type="protein sequence ID" value="CAGL0K10098g-T-p1"/>
        <property type="gene ID" value="CAGL0K10098g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890214"/>
    <dbReference type="KEGG" id="cgr:2890214"/>
    <dbReference type="CGD" id="CAL0133909">
        <property type="gene designation" value="CAGL0K10098g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K10098g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10098g"/>
    <dbReference type="eggNOG" id="KOG3451">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166246_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FM86"/>
    <dbReference type="OMA" id="IYNPMDE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006294">
        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1220:FF:000002">
        <property type="entry name" value="RNA polymerase II transcription factor B subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1220">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035935">
        <property type="entry name" value="TFB5-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009400">
        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28580:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06331">
        <property type="entry name" value="Tfb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01395">
        <property type="entry name" value="Tbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142897">
        <property type="entry name" value="TFB5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000119279" description="General transcription and DNA repair factor IIH subunit TFB5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q3E7C1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="73" mass="8617" checksum="C24369A9CA445FE2" modified="2004-07-19" version="1">MVRARRGVLLKCDPSIKALIVQIDSERHDIILEELDETHLLVHPTKVEFIKMELNRLLSKNIYNPLDEEEEEH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMA9</accession>
    <name>SMP3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>GPI mannosyltransferase 4</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GPI mannosyltransferase IV</fullName>
            <shortName>GPI-MT-IV</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SMP3</name>
        <name type="ordered locus">CAGL0K09548g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi.</text>
    </comment>
    <comment type="pathway">
        <text>Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448635.1">
        <property type="nucleotide sequence ID" value="XM_448635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMA9"/>
    <dbReference type="FunCoup" id="Q6FMA9">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMA9"/>
    <dbReference type="CAZy" id="GT22">
        <property type="family name" value="Glycosyltransferase Family 22"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q6FMA9">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0K09548g-T">
        <property type="protein sequence ID" value="CAGL0K09548g-T-p1"/>
        <property type="gene ID" value="CAGL0K09548g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890237"/>
    <dbReference type="KEGG" id="cgr:2890237"/>
    <dbReference type="CGD" id="CAL0134813">
        <property type="gene designation" value="CAGL0K09548g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09548g"/>
    <dbReference type="eggNOG" id="KOG4123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022957_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FMA9"/>
    <dbReference type="OMA" id="GIMHQNG"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000246275" description="GPI mannosyltransferase 4">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="496" mass="57033" checksum="EBF98F87E4E4DD77" modified="2004-07-19" version="1">MDNKLIWLLPAIGLVVALQPSYIHPDEHFQTLEMLMIKFYGISGTVPWEFEPTNNARSYFPLYAFYGPLFYLMRDILKVQNPLNILRIIRFYNFMLYLSVLYYALPKLVNENKLQNKGRVNEALVFILSSYITWCYQCHSFSNSLETILLLLVLSNYTDILSNKAGLLQLVSTGFLISVGTFTRISFPAFLLLPSIQVFLKVLYRKWIQMVVIAVSMTLSTSIIVYFDTFMYESDEIIIAPLKNVVYNLNVDNLAKHGLHPRYTHLLVNIPLILGPGLLMIRNTKNDFLNLPLLSIISSLFFLSALRHQELRFLLPVVPLFSTLLTRFRYRPYLFRIWLVFNAAMCIIMGIFHQGGVIPMISNINAEQDLTIDIWWKTYSPPTWLYNNDILTVSTTSIVNNIENLDLVQFNVKTNHVVDLKGCDFDLVLEAIQNFRINGVKSLRLIVPNSMTSNVAALNQTYLVTKENSVFPHLDLDHLDSGIQNIIGLSEYKVSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMF8</accession>
    <name>RS21_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small ribosomal subunit protein eS21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>40S ribosomal protein S21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPS21</name>
        <name type="ordered locus">CAGL0K08382g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text>Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMF8"/>
    <dbReference type="SMR" id="Q6FMF8"/>
    <dbReference type="FunCoup" id="Q6FMF8">
        <property type="interactions" value="1031"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMF8"/>
    <dbReference type="EnsemblFungi" id="CAGL0K08382g-T">
        <property type="protein sequence ID" value="CAGL0K08382g-T-p1"/>
        <property type="gene ID" value="CAGL0K08382g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890354"/>
    <dbReference type="CGD" id="CAL0134011">
        <property type="gene designation" value="CAGL0K08382g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K08382g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08382g"/>
    <dbReference type="eggNOG" id="KOG3486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167122_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FMF8"/>
    <dbReference type="OMA" id="GESDACM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000461">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000194757" description="Small ribosomal subunit protein eS21">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="87" mass="9723" checksum="52E1C9CACD391F04" modified="2004-07-19" version="1">MENDKGQLVELYIPRKCSATNRIIKADDHASVQINIAKVDEEGRAIPGEYITYALSGNVRARGESDDSLNRLAQNDGLLKNVWSYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMZ3</accession>
    <name>Q6FMZ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FKS2</name>
        <name evidence="14 15" type="ordered locus">CAGL0K04037g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q6FMZ3"/>
    <dbReference type="FunCoup" id="Q6FMZ3">
        <property type="interactions" value="744"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMZ3"/>
    <dbReference type="CAZy" id="GT48">
        <property type="family name" value="Glycosyltransferase Family 48"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890040"/>
    <dbReference type="CGD" id="CAL0134701">
        <property type="gene designation" value="FKS2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04037g"/>
    <dbReference type="eggNOG" id="KOG0916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000844_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FMZ3"/>
    <dbReference type="OMA" id="AWTDFFI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="695"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1379"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1466"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1493"/>
            <end position="1510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1581"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1620"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1662"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1691"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1822"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="319"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0134701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG61362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1897" mass="217612" checksum="14AD1B7BD5F336AB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN12</accession>
    <name>SPC24_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Probable kinetochore protein SPC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SPC24</name>
        <name type="ordered locus">CAGL0K03619g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <text evidence="2">Associated with kinetochores.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448382.1">
        <property type="nucleotide sequence ID" value="XM_448382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN12"/>
    <dbReference type="SMR" id="Q6FN12"/>
    <dbReference type="FunCoup" id="Q6FN12">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN12"/>
    <dbReference type="EnsemblFungi" id="CAGL0K03619g-T">
        <property type="protein sequence ID" value="CAGL0K03619g-T-p1"/>
        <property type="gene ID" value="CAGL0K03619g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890132"/>
    <dbReference type="KEGG" id="cgr:2890132"/>
    <dbReference type="CGD" id="CAL0134409">
        <property type="gene designation" value="CAGL0K03619g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03619g"/>
    <dbReference type="eggNOG" id="ENOG502S3GS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095757_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN12"/>
    <dbReference type="OMA" id="ENMPPNA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000246661" description="Probable kinetochore protein SPC24">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="24"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q04477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="201" mass="23155" checksum="48A281542F00FDAA" modified="2004-07-19" version="1">MASTEEIVQMMQEASAEFAEADDVSFLDKMNSNIAQLEQQLREQMDESRQNIAKLEINLIDTEKSIGSLRELMKDATDEATIMKGSDKLNNLIDELQATENEIQMMNSEIEKKVSKLVEDEDNTSSEYEMISKELEQEYDPVFASNILKLKLYRSLGVRLDLDNNQILIQNKELGTIDTLPLEDELTEFFKVKYIWSRIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNH4</accession>
    <name>Q6FNH4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0J11660g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448220.1">
        <property type="nucleotide sequence ID" value="XM_448220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNH4"/>
    <dbReference type="STRING" id="284593.Q6FNH4"/>
    <dbReference type="KEGG" id="cgr:2889460"/>
    <dbReference type="CGD" id="CAL0133626">
        <property type="gene designation" value="CAGL0J11660g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11660g"/>
    <dbReference type="eggNOG" id="KOG0981">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009193_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FNH4"/>
    <dbReference type="OMA" id="HRWKEVK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.10:FF:000003">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018521">
        <property type="entry name" value="TopoIB_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00176">
        <property type="entry name" value="TOPO_IB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="267"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="604"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0133626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="744" mass="86963" checksum="9018F29970640D10" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNH5</accession>
    <name>Q6FNH5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0J11638g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="8"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNH5"/>
    <dbReference type="FunCoup" id="Q6FNH5">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNH5"/>
    <dbReference type="KEGG" id="cgr:2889459"/>
    <dbReference type="CGD" id="CAL0133112">
        <property type="gene designation" value="CAGL0J11638g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11638g"/>
    <dbReference type="eggNOG" id="KOG0575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_46_2_1"/>
    <dbReference type="InParanoid" id="Q6FNH5"/>
    <dbReference type="OMA" id="IQIHKSM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090619">
        <property type="term" value="C:meiotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031619">
        <property type="term" value="P:homologous chromosome orientation in meiotic metaphase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990813">
        <property type="term" value="P:meiotic centromeric cohesion protection in anaphase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090306">
        <property type="term" value="P:meiotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990395">
        <property type="term" value="P:meiotic spindle pole body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904750">
        <property type="term" value="P:negative regulation of protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045793">
        <property type="term" value="P:positive regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140281">
        <property type="term" value="P:positive regulation of mitotic division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140429">
        <property type="term" value="P:positive regulation of mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010696">
        <property type="term" value="P:positive regulation of mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110083">
        <property type="term" value="P:positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031031">
        <property type="term" value="P:positive regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903353">
        <property type="term" value="P:regulation of nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902542">
        <property type="term" value="P:regulation of protein localization to mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070194">
        <property type="term" value="P:synaptonemal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000647">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000005">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="81"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="10">
        <location>
            <begin position="553"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="10">
        <location>
            <begin position="654"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0133112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="746" mass="85897" checksum="04C6418DC4E1F1D2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNM4</accession>
    <name>Q6FNM4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J10538g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448170.1">
        <property type="nucleotide sequence ID" value="XM_448170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNM4"/>
    <dbReference type="KEGG" id="cgr:2889608"/>
    <dbReference type="CGD" id="CAL0129491">
        <property type="gene designation" value="CAGL0J10538g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10538g"/>
    <dbReference type="eggNOG" id="ENOG502QR2T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010834_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FNM4"/>
    <dbReference type="OMA" id="IILWATH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="410" mass="46174" checksum="EC2F6B920D185E9A" modified="2004-07-19" version="1">MTVRPELSFPAKDLRRNLISLQPIENFVPVTCDTKRPIKCLIIGVHGYFPNKAVDIILGERTGTSQRFVSQAESAVQLYFKELGVAVDTTTLALEKEGTVAKRVEFFVDVLGEYRETLAEADFIYFVSHSQGVPVTVNLIGHLLIKGILQLDIDRVSHMSDKPIYTQEKIVSVLGMAGVNYGPLYGADKNIWLRLFSVVERKSLMELFEFQNPATKLSMDYMEKVQYILDAGVKITFVGSVNDQVVPLYSSLASFLQHPNIQRGIFYTSQCDVPPFIMGCILDSITLLNSGKKDQGFIKEISPYLHGPLTGNGHSDLYFQSEVYTYGIKHALNSQSIKHCPSPIIRSDIVSLKVNPYNLPWTMRGLLNEIEKELGKEEVKKLYKLYDEWAPNTPLHQSLRIKLSGVTSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNQ9</accession>
    <name>Q6FNQ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial GTP/GDP carrier protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0J09790g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNQ9"/>
    <dbReference type="FunCoup" id="Q6FNQ9">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNQ9"/>
    <dbReference type="KEGG" id="cgr:2889420"/>
    <dbReference type="CGD" id="CAL0133086">
        <property type="gene designation" value="CAGL0J09790g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09790g"/>
    <dbReference type="eggNOG" id="KOG0750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053371_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNQ9"/>
    <dbReference type="OMA" id="GQPWFSD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="117"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="211"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0133086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32910" checksum="6960F6D484239E2F" modified="2004-07-19" version="1">MAHNDRKQSGVARLLGSASAGILEIGVFHPVDTISKRLMSNHTKITSGAQLNSVIFRDHAAEAFGKRVFTLFPGLGYAAVYKILQRVYKYGGQPFANEFLNKHFKKDFDSAFGDKTGKALRSATAGSLIGIGEIVLLPLDVLKIKRQTNPEAFKGRGFLKILKDEGIFNLYRGWGWTAARNAPGSFALFGGNAFAKEYILGLQDYSQATWSQNFISSIVGASASLIVSAPLDVIKTRIQNRNFDNPESGFKIVKNTLKNEGFTAFFKGLTPKLLTTGPKLVFSFALAQSLIPMFDNMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNR6</accession>
    <name>Q6FNR6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nuclear pore protein GLE1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Nucleoporin GLE1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">RNA export factor GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0J09636g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNR6"/>
    <dbReference type="FunCoup" id="Q6FNR6">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNR6"/>
    <dbReference type="KEGG" id="cgr:2889716"/>
    <dbReference type="CGD" id="CAL0132914">
        <property type="gene designation" value="CAGL0J09636g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09636g"/>
    <dbReference type="eggNOG" id="KOG2412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029651_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNR6"/>
    <dbReference type="OMA" id="VPANIHS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.510:FF:000003">
        <property type="entry name" value="Nucleoporin GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="168"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00075092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0132914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG61079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="530" mass="61019" checksum="CB36ECEF0CA10B68" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNT5</accession>
    <name>Q6FNT5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Regulator of phospholipase D SRF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0J09196g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNT5"/>
    <dbReference type="FunCoup" id="Q6FNT5">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889947"/>
    <dbReference type="CGD" id="CAL0132780">
        <property type="gene designation" value="CAGL0J09196g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09196g"/>
    <dbReference type="eggNOG" id="ENOG502QPXG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027163_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FNT5"/>
    <dbReference type="OMA" id="TRFDKEW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="53259" checksum="6748AFC03B3DAAB6" modified="2004-07-19" version="1">MERMVKDVVGHPQDPDERSDNSVSDQPRVDGGKQSNKGNVGHGNGVSDHKRQMVSLNPYGLYPSTVPPFVLESDFRRLHGINDDFNDREVRWANFIGNVGSNVAYSTEQRLPSRGIANNATLRHNYSVGNIKDQPNRHIEDIIDPLVSTGNNSINESASLDHEEMERKRKIQEEILYDLDSEWKGGERLDAVFNFSVNKDFEFKNEKDRIDWVNYISKVKNAYYAPNKESSGINDESSSSLSQQQEGNRGDRQNYDWIEELNKEKEKWKKLKQRKIQKWKPALSNLLFYNQYLPLGFRIVIGILCLISLGLSVRIYQNSDSSIEQVEGGGADLDTGIPQQASTIMAICVNTIAIAYTFYIAIDEFSGKPLGLRNPLGKLKLILLDLLFIIFASANLALAFNTRFDKEWVCTGLGVTIAEEEVYYPKIPYICRKQKALASFLFVLLFAWVVTFSVSIARVVDKVHSSATRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP02</accession>
    <name>CWC25_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor CWC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CWC25</name>
        <name type="ordered locus">CAGL0J07700g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CWC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448042.1">
        <property type="nucleotide sequence ID" value="XM_448042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP02"/>
    <dbReference type="SMR" id="Q6FP02"/>
    <dbReference type="FunCoup" id="Q6FP02">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP02"/>
    <dbReference type="EnsemblFungi" id="CAGL0J07700g-T">
        <property type="protein sequence ID" value="CAGL0J07700g-T-p1"/>
        <property type="gene ID" value="CAGL0J07700g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889902"/>
    <dbReference type="KEGG" id="cgr:2889902"/>
    <dbReference type="CGD" id="CAL0133598">
        <property type="gene designation" value="CAGL0J07700g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J07700g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07700g"/>
    <dbReference type="eggNOG" id="KOG3869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025093_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FP02"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000384">
        <property type="term" value="F:first spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051376">
        <property type="entry name" value="CWC25_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16196:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000079586" description="Pre-mRNA-splicing factor CWC25">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="176" mass="20659" checksum="A5A68FBD50BA631A" modified="2004-07-19" version="1">MGTGDLNLLKSWNPKLVKNRKKVWEKEQRLLEEDEKIRKRQLEIAKEKEEEELLAGRDSTKGRKTGLEWMYQDDPTAKEDYLLGKKKLDTTVIKKAEVMEENQTPLTKINKTTVIPDAIYSKEDPMARFGTKVKRNKVVKKEPVKPLRGKTTNEPRTDNIKPKSDYKKRLQEELDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP45</accession>
    <name>Q6FP45_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTD kinase subunit gamma Ctk3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J06754g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP45"/>
    <dbReference type="FunCoup" id="Q6FP45">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP45"/>
    <dbReference type="KEGG" id="cgr:2889551"/>
    <dbReference type="CGD" id="CAL0133352">
        <property type="gene designation" value="CAGL0J06754g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06754g"/>
    <dbReference type="eggNOG" id="ENOG502RZM5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056411_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP45"/>
    <dbReference type="OMA" id="HYEDFHQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTD kinase subunit gamma Ctk3 C-terminal" evidence="1">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="349" mass="40145" checksum="F53EAD81BB4F1D78" modified="2004-07-19" version="1">MDSFEARLQFIQVIKNLQKSLNVSKEDTDGTLGIGLGSGQSSGANSVSHSGSYSNIQELDDTTIGTQVSKSMSDPLQFYLKHYAHHYEDFHQCLFDTGLKMDPLHRLNIVIFYYQIILALVAEMKKRKLDTSSLQATVVYEHLIPSMPRIFEICLPKDDWKALSNLKSCTDIYYNLLRLLKTLPGYQLEMSPEEMTLSEYTMDSEEVIQAMTQPTSELDWKTIANDDKPQNVSQSILWTRELLNDRMIKKYVVFKTFVTNGVCNLKNSHNSSTSNNNVSNILHRMENDRERHKRQKENNWVVERVSQSMLDENEFKAAWNSITSLPSLSRSDQKDIRQLHTIARGSYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP60</accession>
    <name>Q6FP60_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0J06380g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447984.1">
        <property type="nucleotide sequence ID" value="XM_447984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP60"/>
    <dbReference type="FunCoup" id="Q6FP60">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP60"/>
    <dbReference type="KEGG" id="cgr:2889535"/>
    <dbReference type="CGD" id="CAL0133570">
        <property type="gene designation" value="CAGL0J06380g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06380g"/>
    <dbReference type="eggNOG" id="ENOG502SCJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145563_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FP60"/>
    <dbReference type="OMA" id="RCISRNT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64602">
        <property type="entry name" value="F1 ATPase inhibitor, IF1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0133570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="93" mass="10812" checksum="D94B18F30D28691D" modified="2004-07-19" version="1">MLRLNAINTLKQSKSVTPACQTAMRRYSNIPPPVGGFSSTGQSDTFNKREKAAEDYFIKQHEKEQLKNLREQLKHHKEQLQDLEEKIEKITKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP62</accession>
    <name>Q6FP62_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J06336g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447982.1">
        <property type="nucleotide sequence ID" value="XM_447982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP62"/>
    <dbReference type="STRING" id="284593.Q6FP62"/>
    <dbReference type="KEGG" id="cgr:2889533"/>
    <dbReference type="CGD" id="CAL0133072">
        <property type="gene designation" value="CAGL0J06336g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06336g"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018149_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP62"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012104">
        <property type="entry name" value="PHO85_cyclin_1/2/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016511">
        <property type="entry name" value="Cyclin_Pcl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="55"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="314" mass="35951" checksum="CD234C777C72395E" modified="2004-07-19" version="1">MFETPPYCGLNPVEYEILVRFLKRNVTYEMLTFLISKTNSMIKIKKTNSPKPVELSLFVEELVASSKVQASTLMATAVYLDRLSRIIPSNVCGIETTKHRMFLGCLILSSKSLDDSSLFNKHWTKYCNGLLTLKEVNSIERELLSYFNWDINIQIEELYNTLEPILKPIREEMVTRRYTLYLPTPSSSPGKIDGRIKLSSHPVLQKQIAEEISTYLDDASPVSSISTFYDSESPTSMQSGHNGRLYLCDNCSTPALGNSTVSSEYVLDSSNQRKRGHSSDLKSTKSEEEESNLEYLFKRDKKLVRWNNRWSMVF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP78</accession>
    <name>ADE_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine deaminase</fullName>
            <shortName evidence="1">ADE</shortName>
            <ecNumber evidence="1">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Adenine aminohydrolase</fullName>
            <shortName evidence="1">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AAH1</name>
        <name type="ordered locus">CAGL0J05984g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="1"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447966.1">
        <property type="nucleotide sequence ID" value="XM_447966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP78"/>
    <dbReference type="SMR" id="Q6FP78"/>
    <dbReference type="FunCoup" id="Q6FP78">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP78"/>
    <dbReference type="EnsemblFungi" id="CAGL0J05984g-T">
        <property type="protein sequence ID" value="CAGL0J05984g-T-p1"/>
        <property type="gene ID" value="CAGL0J05984g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889775"/>
    <dbReference type="KEGG" id="cgr:2889775"/>
    <dbReference type="CGD" id="CAL0133440">
        <property type="gene designation" value="CAGL0J05984g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J05984g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05984g"/>
    <dbReference type="eggNOG" id="KOG1097">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039228_7_0_1"/>
    <dbReference type="InParanoid" id="Q6FP78"/>
    <dbReference type="OMA" id="NHFTIHA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000039">
        <property type="entry name" value="Adenine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF6">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000256233" description="Adenine deaminase">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03145"/>
        </source>
    </evidence>
    <sequence length="347" mass="39697" checksum="F48170A9E08B8C9F" modified="2004-07-19" version="1">MVPESFLLELPKCEHHLHLEGTLEPDLLFPLAKRNNIQLPDHFPQTPEELAVRYTQFKDLQDFLDYYYIGTNVLLKEEDFFDLAWAYFTKVSKQGLVHAELFYDPQSHTTRGVSLETVTRGFERACKKAHEELGITSKLIMCLLRHLPPQDCLQTIEEAEQLIKSGVIHGLGLDSAEKPFPPSLFVECYERAAKINPELRLTAHAGEEGTHQFVSDALDLLNVTRIDHGVNSKQSEELMARLAEQQTLLTVCPLSNVKLQVVQSVKEIPLQLFLDKNIAFSLNSDDPAYFGGYILDNYYQVNKDFPDWDFKVWERIAKNGINGSWCEQKRKEELLAKVDAVVAKYTN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPD9</accession>
    <name>DPH2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Diphthamide biosynthesis protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Diphtheria toxin resistance protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DPH2</name>
        <name type="ordered locus">CAGL0J04576g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1 (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the DPH1 subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447905.1">
        <property type="nucleotide sequence ID" value="XM_447905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPD9"/>
    <dbReference type="SMR" id="Q6FPD9"/>
    <dbReference type="FunCoup" id="Q6FPD9">
        <property type="interactions" value="1010"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPD9"/>
    <dbReference type="EnsemblFungi" id="CAGL0J04576g-T">
        <property type="protein sequence ID" value="CAGL0J04576g-T-p1"/>
        <property type="gene ID" value="CAGL0J04576g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889446"/>
    <dbReference type="KEGG" id="cgr:2889446"/>
    <dbReference type="CGD" id="CAL0133634">
        <property type="gene designation" value="CAGL0J04576g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04576g"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015210_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FPD9"/>
    <dbReference type="OMA" id="QIWNENH"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120513">
        <property type="term" value="C:2-(3-amino-3-carboxypropyl)histidine synthase complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000083385" description="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2">
        <location>
            <begin position="1"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="551" mass="61807" checksum="119AA0EAF51EF506" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPK3</accession>
    <name>Q6FPK3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0J03146g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
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    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
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        <property type="entry name" value="RIBORDTASEM1"/>
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    <sequence length="894" mass="100462" checksum="78BF53E31557AF46" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ20</accession>
    <name>Q6FQ20_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CTP-dependent diacylglycerol kinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I09812g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
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            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        <property type="term" value="P:mitotic nuclear membrane biogenesis"/>
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    </dbReference>
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        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001210">
        <property type="term" value="P:regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Dgk1-like"/>
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        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="164"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="234"/>
            <end position="250"/>
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            <begin position="262"/>
            <end position="279"/>
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            <begin position="1"/>
            <end position="27"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32448" checksum="1CEAC05A6D4E697F" modified="2004-07-19" version="1">MSHSQSNSNSDSNIKNRKRTGSRVDPMYDAKNPKYKHAEDIHLPVTEIHLKSHEWFGDFITKHEIPRKLFHSSIGFITLYYYTKGVDYRLVNPFLIVGFVTVFVLDCIRLNWPFFNFLYCRVVGALMRKKEIHTYNGVLWYLLGLIYSFTFFSKDVILISLFLLSWSDTAASTIGRRYGYLTPKITKNKSLAGSLAAFVVGFLTCLSFYGFFVPHYNWANKSGEIMWTPETSRLGLYQISFLGGFVASLSEGVEIFNWDDNFTIPVLSSIFMNAVIKFFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ23</accession>
    <name>Q6FQ23_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0I09746g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ23"/>
    <dbReference type="FunCoup" id="Q6FQ23">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888944"/>
    <dbReference type="CGD" id="CAL0129915">
        <property type="gene designation" value="CAGL0I09746g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09746g"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019048_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FQ23"/>
    <dbReference type="OMA" id="FWYTVSS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="96"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0129915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="463" mass="51628" checksum="F3024A6B5ADFF037" modified="2004-07-19" version="1">MIQTQHITTTKRRGSLHKNLFDPEVVNIPSPKSYNYAGKREYRGSSARNGLLYTINPREQFLSSLIGEEQWEYLHESFTSGLAYIQQTLSSRSKLQIPLLCLVWYVVSSISSNLCRTILKGFPHPVALTEIQFLFTAILCTSFISLINYYERPRRHHSGLSHWVRMFPEGTFPEYLDGDFHNSIVNKFLKPSALAMQCCLPLGIFQFVGHISTHKATSMIPVSLVHSMKALSPIVTVGYYRLVEQKQYTRATYTSLCAIVAGVICTCFSGKSKSNREPHYYQGLLFALLSMAIFVAQNIFAKGVLTHKSSKSAKSVRGARGANSKPDKGQLDKITILLYCSCIGFVLTLPVLLSSMLFSSAVTTTYHPFFKLVALLLLHNVAHFLQAMLAFQLIGLLSPVNYSVANIAKRIVVICVALLWESKHSPAGLLGVAVTMAGLYGYDRARSETPGLRHPPQNKYTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQH9</accession>
    <name>Q6FQH9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FBP26</name>
        <name evidence="7 8" type="ordered locus">CAGL0I06094g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447515.1">
        <property type="nucleotide sequence ID" value="XM_447515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQH9"/>
    <dbReference type="FunCoup" id="Q6FQH9">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQH9"/>
    <dbReference type="GeneID" id="2889373"/>
    <dbReference type="KEGG" id="cgr:2889373"/>
    <dbReference type="CGD" id="CAL0132240">
        <property type="gene designation" value="FBP26"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06094g"/>
    <dbReference type="eggNOG" id="KOG0234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006383_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQH9"/>
    <dbReference type="OMA" id="RWIQERC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0132240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="450" mass="51978" checksum="BF3B95A1310529BC" modified="2004-07-19" version="1">MPVTTISNMNDSRICVVMVGLPARGKSFISQKILRYLSWLSINAKCFNVGNYRYKAGVIKPDAKFFDFNNPEGYRVREEAAQQAVSDMLKWYEEENGVVAVLDATNSTRKRRDWILEICAQNNIMPMFIESWCDNEKIVETNVIDISTTSPDYEGSDPEESKRDLYNRIACYRDAYETLSLENDNNMTFVKLVNIEDEIIINKIQSYLQSRIVFYVMNIRPKPRTIWLSRHGESIYNVEKKIGGDSLLSPRGVQYSKKLKELVDEHVGDAPLTVWTSTLVRTQQTAQHLPYKKLQWKALDELDAGVCDGMTYEEIEEVYPEDFKARDEDKYEYRYRGGESYRDVVVRLEPVIMELERQENVLIITHQAVLRCIYAYFMNVPQEESPWMSIPLHTLIKLEPRAYGTKVTRIKANIPAVSTYKEKGTSQVGESAADLSKFQKLLVDAPELKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQM6</accession>
    <name>Q6FQM6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRP2</name>
        <name evidence="10 11" type="ordered locus">CAGL0I05016g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447468.1">
        <property type="nucleotide sequence ID" value="XM_447468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQM6"/>
    <dbReference type="FunCoup" id="Q6FQM6">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQM6"/>
    <dbReference type="GeneID" id="2889086"/>
    <dbReference type="KEGG" id="cgr:2889086"/>
    <dbReference type="CGD" id="CAL0132266">
        <property type="gene designation" value="TRP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05016g"/>
    <dbReference type="eggNOG" id="KOG1223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_1"/>
    <dbReference type="InParanoid" id="Q6FQM6"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005950">
        <property type="term" value="C:anthranilate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.120.10:FF:000003">
        <property type="entry name" value="Anthranilate synthase component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="9">
        <location>
            <begin position="37"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="8">
        <location>
            <begin position="228"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0132266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="506" mass="57088" checksum="26C737C0038A7E94" modified="2004-07-19" version="1">MQIQPDLPTLKGLYEQNNALDEGINMYPVYAFLPALDLTPHVAYLKLAQLNNKDRTESFLLESAKTTDELDRYSFIGVSPRKIIKTGPTEGIETDPLDVLEEEMSQFKLATNVPGLPKLSGGAIGYISYDCIRYFEPKTKRDLKDVLQLPEAYLMMCDTIIAFDHVFQRFQIMHNINTKKQSLEEGYSHAVEIINDIIKRMTDDSKPIPYPEQPPIKMDRSFQSNIGQEGYENHVGNLIEHIKKGDIIQAVPSQRVARPTDLHPFNIYRHLRTVNPSPYLFYIDCLDFQIIGASPELLCKSDSKNKVITHPIAGTIKRGATTEEDDELGNQLRNSLKDRAEHVMLVDLARNDINRVCDPKTTNVDKLLTIQKFSHVQHLVSQVSGTLRPDKTRFDAFRSIFPAGTVSGAPKVKAMELISELEGERRGVYAGAVGNWSYDGKTMDTCIALRTMVYKNGTAYLQAGGGIVFDSDKYDEYIETMNKMMANHNTIVQAEKIWAEKVGTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQT1</accession>
    <name>Q6FQT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cardiolipin synthase (CMP-forming)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0I03784g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQT1"/>
    <dbReference type="FunCoup" id="Q6FQT1">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQT1"/>
    <dbReference type="KEGG" id="cgr:2889256"/>
    <dbReference type="CGD" id="CAL0132524">
        <property type="gene designation" value="CAGL0I03784g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03784g"/>
    <dbReference type="eggNOG" id="KOG1617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FQT1"/>
    <dbReference type="OMA" id="RIAMSPY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043337">
        <property type="term" value="F:cardiolipin synthase (CMP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007006">
        <property type="term" value="P:mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF60">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE (CMP-FORMING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0132524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30114" checksum="797217D0B53DFD28" modified="2004-07-19" version="1">MSIPMLPAILSKNVGLRSIRCVRGGYLRVVLGASIGMRPYSDLKVNKKDFLTIPNVITITRIATTPMIGYFLLNNQLVPALSLFAYSSITDFLDGYIARRYNMKSDAGTILDPMADKLLMIITTAALALPPGPQVIPIGIASLILGRDILMGFSAIFIRYASLKQKYHFVTWKSFWDFFKYPSAVVKPLTISKWNTFLQMIYLGLAVFIMILDQYDTKVQEANEQKDTTLDINTLKTGFSWLGYIVGATTVISGTSYVFSKSAVTFIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQV0</accession>
    <name>Q6FQV0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0I03366g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQV0"/>
    <dbReference type="FunCoup" id="Q6FQV0">
        <property type="interactions" value="883"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQV0"/>
    <dbReference type="KEGG" id="cgr:2889056"/>
    <dbReference type="CGD" id="CAL0130199">
        <property type="gene designation" value="CAGL0I03366g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03366g"/>
    <dbReference type="eggNOG" id="KOG3347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079096_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FQV0"/>
    <dbReference type="OMA" id="QCEIFGT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0130199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="212" mass="24317" checksum="10C05AED7984FE55" modified="2004-07-19" version="1">MGSRRFHPNIIVTGTPGCGKSTTCELLQRRLDGYKYYNISEFAEEHKCYDGYDEGRKSHIVDEDKLLDELEPLLLEGKSIIDWHVNDVFPERLIDLVVVLRSENGKLYDRLKARGYHDSKIEENLDAEIMGVVLQDAQESYEPEIVVELQSNTTEDMENNVDRINTWVDNWVEEHKDGVSSELKDGKKYASYSSEEEEETSDGEDEEASASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR82</accession>
    <name>Q6FR82_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EPA23</name>
        <name evidence="5 6" type="ordered locus">CAGL0I00220g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447262.1">
        <property type="nucleotide sequence ID" value="XM_447262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR82"/>
    <dbReference type="STRING" id="284593.Q6FR82"/>
    <dbReference type="GeneID" id="2889307"/>
    <dbReference type="KEGG" id="cgr:2889307"/>
    <dbReference type="CGD" id="CAL0130346">
        <property type="gene designation" value="EPA23"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00220g"/>
    <dbReference type="eggNOG" id="ENOG502S8JT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OMA" id="DPIANSC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000128">
        <property type="term" value="P:flocculation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flocculin"/>
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        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
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    <dbReference type="Pfam" id="PF00624">
        <property type="entry name" value="Flocculin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273512" description="PA14 domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="843"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="4">
        <location>
            <begin position="86"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0130346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="864" mass="94523" checksum="4A8B27795AF7E682" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRC7</accession>
    <name>Q6FRC7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H09636g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447217.1">
        <property type="nucleotide sequence ID" value="XM_447217.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FRC7">
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    </dbReference>
    <dbReference type="KEGG" id="cgr:2888740"/>
    <dbReference type="CGD" id="CAL0131548">
        <property type="gene designation" value="CAGL0H09636g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09636g"/>
    <dbReference type="eggNOG" id="ENOG502RZ5Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072626_0_1_1"/>
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    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019619">
        <property type="term" value="P:3,4-dihydroxybenzoate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF28">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="25397" checksum="AA14D591BC10DAD1" modified="2004-07-19" version="1">MTLEGYVVKLKDYGACDVSDGLLHYCKIDDGGFFPDLIQRSGPHKTIVGPAYTVLFASVDDPRPEVNYIDNIPAGAFMIIALEKSLQEKPEQITQALYGGLMANRAQYQNSAGTIVFGRVRDLGEHKECGQPLFSLGVGTCAPKKAVKPVATNVSLPILLPNGCTSAISPGDVLVADENGVVRIPKDTLLESGDKLINYIEQQIAADTLVMEDIRNGIPAKQSQKDRRAALKQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRI1</accession>
    <name>Q6FRI1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0H08371g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRI1"/>
    <dbReference type="FunCoup" id="Q6FRI1">
        <property type="interactions" value="968"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRI1"/>
    <dbReference type="KEGG" id="cgr:2888787"/>
    <dbReference type="CGD" id="CAL0130048">
        <property type="gene designation" value="CAGL0H08371g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08371g"/>
    <dbReference type="eggNOG" id="KOG2872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRI1"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0130048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG60096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="360" mass="40787" checksum="A359A37A983523D6" modified="2004-07-19" version="1">MFPELKNDLILRAARGEAVERPPCWLMRQAGRYLPEYHEVKGNRDFFEVCRDAEVASEITIQPVRRYAGLLDAAIIFSDILVIPQAMGMKVEMVEGKGPHFPEPLRTSEDLQKVLDYKVDIKKELNWAFEAITLTRKKLDGQVPLFGFCGAPWTLLVYMTEGGGSRLFRFAKQWINEKPEESHKLLQAITDVAVEFLAQQVVAGAQILQVFESWGGELSAGDFDEFSLPYLRQIATKVPKRLKELGVEEHIPMIVFAKGSWYALDKLCDSGYNVVSLDWCWDPKEAVKINNNRVVLQGNLDPGVMYGSDEIISKKTKTMIEGFGGGKKNYIVNFGHGTHPFMDTEKIRHFLEECHRIGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRI2</accession>
    <name>Q6FRI2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0H08349g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRI2"/>
    <dbReference type="FunCoup" id="Q6FRI2">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRI2"/>
    <dbReference type="KEGG" id="cgr:2888893"/>
    <dbReference type="CGD" id="CAL0130060">
        <property type="gene designation" value="CAGL0H08349g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08349g"/>
    <dbReference type="eggNOG" id="KOG2505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014293_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FRI2"/>
    <dbReference type="OMA" id="AQKTIHR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036266">
        <property type="term" value="C:Cdc48p-Npl4p-Vms1p AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072671">
        <property type="term" value="P:mitochondria-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="12">
        <location>
            <begin position="233"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="581"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0130060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG60095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="650" mass="74214" checksum="6219A5B07B95448F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRY1</accession>
    <name>Q6FRY1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0H05005g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRY1"/>
    <dbReference type="FunCoup" id="Q6FRY1">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888669"/>
    <dbReference type="CGD" id="CAL0131440">
        <property type="gene designation" value="CAGL0H05005g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05005g"/>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016665_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FRY1"/>
    <dbReference type="OMA" id="WRLIKGW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901352">
        <property type="term" value="P:negative regulation of phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001247">
        <property type="term" value="P:positive regulation of phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="201"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0131440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="452" mass="52109" checksum="1563CA7285EC2DFE" modified="2004-07-19" version="1">MTTSKDTMSSNKKESHLPLEREVVLSPEKELLLKQAWVYLLQLWGVSVNGDIVFKDAHHGDIDGLSTQMSALSTGSSEPKKKKTSLFGRLTGSDHHDTSKHATHETEHHTRHTQIPYVKDGVHPEFTKLELDSKATYKEFWESLRLEPADPNILRFLKARKWHMDKTIHMIAKDMSWRTKSGYDINSILDGGEYEFVKTKKKGVIKNLELQKAIVAGKDKDGKPYILARPKLHYSSDQTEEEIEKYALLVIEQAKLFLRPPEIAQCSIVFDLGGFSMSNMDYGPVKFLITCFEAHYPECLAHLFIHKAPWIFTPIWNIVKNWLDPTVATKITFTKNVEELARYIDIKQIPTYLGGELDLDMEHYEMPDGSKDELLRDEETRDKLLKEREQLIQNFLKLTAEWIESDDNEKQSISIRNKRALASEKITQNYIQIDPYIRSRSAYDISGALVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRY6</accession>
    <name>Q6FRY6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Platinum sensitivity protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H04895g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRY6"/>
    <dbReference type="FunCoup" id="Q6FRY6">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRY6"/>
    <dbReference type="KEGG" id="cgr:2888678"/>
    <dbReference type="CGD" id="CAL0129656">
        <property type="gene designation" value="CAGL0H04895g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04895g"/>
    <dbReference type="eggNOG" id="ENOG502S12B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103058_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRY6"/>
    <dbReference type="OMA" id="AHCRVYP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19480">
        <property type="entry name" value="Psy3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031779">
        <property type="entry name" value="Psy3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16836">
        <property type="entry name" value="PSY3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0129656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26445" checksum="DB3D1EA07B1924A7" modified="2004-07-19" version="1">MEILKHCRIYPISSFCATTETYFKIPEDLVNQHLALRTRKLGHIHVVEHSFRLSKVKKKLITTNLDENSGLILLIDVISCWKQFARSLVNNGQSIAYLSSASLCQFDGLLNFLGQLIDSPDEALKRCIFTDSYSCLQQPLTGIIIDNLSYYQTPVAMREFSALQKMLKSLRSTFGCWTMTTSYGLEYYNGVEGGTSTLYTSSGTSFTRLPVSYIKDTDLVLMRDTEDTYHLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS02</accession>
    <name>Q6FS02_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0H04543g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446992.1">
        <property type="nucleotide sequence ID" value="XM_446992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS02"/>
    <dbReference type="STRING" id="284593.Q6FS02"/>
    <dbReference type="KEGG" id="cgr:2888895"/>
    <dbReference type="CGD" id="CAL0130326">
        <property type="gene designation" value="CAGL0H04543g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04543g"/>
    <dbReference type="eggNOG" id="KOG0439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1481792_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS02"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="7">
        <location>
            <begin position="27"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0130326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="182" mass="21050" checksum="0C1B8F3199270535" modified="2004-07-19" version="1">MSYFKLIRFIVSNSSHLMLISTASTMYTRIDPEQLVFEDVVQCRRVLRVRNVSDENIIYKVRTTAPDLYIVRPNVHTILQGQELELEFVYLGQETSHSGRDKFMIITAPVGDTSYDKQVLETDWDKIVSGELKHRAVSKKIPVLMTSEEGVRGAREYIPTRKYVIMLCVMLVIVAYILKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSA2</accession>
    <name>Q6FSA2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0H02233g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSA2"/>
    <dbReference type="FunCoup" id="Q6FSA2">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSA2"/>
    <dbReference type="KEGG" id="cgr:2888876"/>
    <dbReference type="CGD" id="CAL0131892">
        <property type="gene designation" value="CAGL0H02233g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02233g"/>
    <dbReference type="eggNOG" id="KOG1626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040684_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FSA2"/>
    <dbReference type="OMA" id="KEVDRWH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000007">
        <property type="entry name" value="Inorganic pyrophosphatase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0131892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="298" mass="33930" checksum="5669236AF9319675" modified="2004-07-19" version="1">MQCYKMAFKKLALINQCRRAYGSIRQGSKYSTTYRQYLKLEDGSVGSYFHDVPIGIQKDKCYVNMVVEVPRWSSGKFEISKELKLNPITQDVKKGKVRFVNNIFPYHGYIHNYGAIPQTWENVTSSSSLPGVKEPLFGDNDPLDCCDIGSTVLKMGDIKTVKVLGSLALVDDGELDWKIMVINTEDPMHEKINNLADVEKYCPGLLDATRYWFKNYKVPTGKPVNEFAFNGEFQDYDKTMKTIEQCHQEWKGLVAGKISASPNILLPTTERKGTSISVKDDRLPDTPVPDHVNKWYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSF7</accession>
    <name>Q6FSF7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0H00869g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSF7"/>
    <dbReference type="FunCoup" id="Q6FSF7">
        <property type="interactions" value="1014"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSF7"/>
    <dbReference type="KEGG" id="cgr:2888531"/>
    <dbReference type="CGD" id="CAL0130635">
        <property type="gene designation" value="CAGL0H00869g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00869g"/>
    <dbReference type="eggNOG" id="KOG2460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018649_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FSF7"/>
    <dbReference type="OMA" id="LAYIKYN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="565"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0130635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="596" mass="68896" checksum="97AB713127DBC0D8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSF8</accession>
    <name>HUT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HUT1</name>
        <name type="ordered locus">CAGL0H00847g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen. Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446836.1">
        <property type="nucleotide sequence ID" value="XM_446836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSF8"/>
    <dbReference type="SMR" id="Q6FSF8"/>
    <dbReference type="FunCoup" id="Q6FSF8">
        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSF8"/>
    <dbReference type="GlyCosmos" id="Q6FSF8">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0H00847g-T">
        <property type="protein sequence ID" value="CAGL0H00847g-T-p1"/>
        <property type="gene ID" value="CAGL0H00847g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888648"/>
    <dbReference type="KEGG" id="cgr:2888648"/>
    <dbReference type="CGD" id="CAL0130036">
        <property type="gene designation" value="CAGL0H00847g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00847g"/>
    <dbReference type="eggNOG" id="KOG1581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036019_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FSF8"/>
    <dbReference type="OMA" id="CGAIGQV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120112">
        <property type="term" value="P:UDP-glucose transmembrane transport into endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000213406" description="UDP-galactose transporter homolog 1">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="362" mass="40395" checksum="D7A9FEE2D5FCBBA3" modified="2004-07-19" version="1">MSKSNSIFPVLFCAAGIYASFLTWALVQEPLTTQVWENSHKRFQCPNVIAVVQAVAAVCVGYFYMRAKGAQRNYGAIAMVRDYAKPLALISFTQSASSPLSQYALQYVDYLTYMLAKSCKMIPVLLVHLIIYRTTISRKKSVVAVLVSIGVTIFTIGGSKGKISGSISGSNDEHFFQKASGFLLLFLSLFMDGLTNATQDKMLKNNRVQMAIQNAETQDKKQQHKVFHTLTGAHMMFALNFFVAIWNIAYLLVIDRGQICNAHAMLKKDPIIVSYLLAYALCGSLGQCFIFYTLELYGSLVLIMITVTRKMMSMLLSIIVFGKTVNATQWLGIVIVFSGITWEALDKRREKKALEAKVQKSE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-23" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSJ4</accession>
    <name>RPC3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName>RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RPC82</name>
        <name type="synonym">RPC3</name>
        <name type="ordered locus">CAGL0G10109g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446800.1">
        <property type="nucleotide sequence ID" value="XM_446800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSJ4"/>
    <dbReference type="SMR" id="Q6FSJ4"/>
    <dbReference type="FunCoup" id="Q6FSJ4">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSJ4"/>
    <dbReference type="EnsemblFungi" id="CAGL0G10109g-T">
        <property type="protein sequence ID" value="CAGL0G10109g-T-p1"/>
        <property type="gene ID" value="CAGL0G10109g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887998"/>
    <dbReference type="KEGG" id="cgr:2887998"/>
    <dbReference type="CGD" id="CAL0130440">
        <property type="gene designation" value="CAGL0G10109g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G10109g"/>
    <dbReference type="eggNOG" id="KOG2587">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010734_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSJ4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20912">
        <property type="entry name" value="RPC3_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000351030" description="DNA-directed RNA polymerase III subunit RPC3">
        <location>
            <begin position="1"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine-zipper">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="666" mass="76187" checksum="F16BAD32C7E5FA98" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSP3</accession>
    <name>Q6FSP3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0G08932g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSP3"/>
    <dbReference type="FunCoup" id="Q6FSP3">
        <property type="interactions" value="814"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSP3"/>
    <dbReference type="KEGG" id="cgr:2888080"/>
    <dbReference type="CGD" id="CAL0129199">
        <property type="gene designation" value="CAGL0G08932g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08932g"/>
    <dbReference type="eggNOG" id="KOG0809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038177_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FSP3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006675">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="235"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0129199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="367" mass="42730" checksum="F519FD8743C4A9BB" modified="2004-07-19" version="1">MFRDRTNLYLSYRRTFPHNVRLSSTYRDDSDKATTEFDIDNEAYPMIEMGVHSKGKNTLPPVFIDIARDIDDYLDKVREHTAKLHKLYQKNSLPGFEDKTHDEKLIEDISFKVIQLFQKCYNIMKKLKGIYDDQTVDGRRLNRGELMILDNVQKSYADKIQIESNKFRALQNNYLKFLNKDDLKPISNNTLKSSSANETALLEEDTIGGIGAREQQEIEEYSRQTLQRRQATSSDNYLHVRDEEITQLAQGVLEVSTIFREMQSLIIDQGTIIDRIDYNLENTVIELKSAQNELNKATTYQKRTQKCKIILLLTLCVIALIFFILLKPRGGSTRVVHEVEQVPVPVHPEINDFENDKRYIEDNIQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSR0</accession>
    <name>Q6FSR0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GTP-binding protein RHO3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0G08558g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSR0"/>
    <dbReference type="FunCoup" id="Q6FSR0">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSR0"/>
    <dbReference type="KEGG" id="cgr:2888124"/>
    <dbReference type="CGD" id="CAL0130426">
        <property type="gene designation" value="CAGL0G08558g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08558g"/>
    <dbReference type="eggNOG" id="KOG0393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_21_2_1"/>
    <dbReference type="InParanoid" id="Q6FSR0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090338">
        <property type="term" value="P:positive regulation of formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010590">
        <property type="term" value="P:regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000780">
        <property type="entry name" value="Rho GTPase Rho3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0130426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="227" mass="25263" checksum="0003B3DE5E0A9C16" modified="2004-07-19" version="1">MAFLCGSSSSQSSGSKKPVERKIVILGDGACGKTSLLNVFTRGYFPEVYEPTVFENYIHDIFVDNRHITLSLWDTAGQEEFDRLRSLSYSDTHTIMLCFSIDSRDSLENVKNKWVGEITDHCEGVNLVLVALKCDLRNNENNVITPNNIQNNRNNNNNNNLITYEEGLAMAKQIGALRYLECSAKLNKGVNEAFTEAARVALTAKNATDNINSNSSSNEKDSFCTIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSR1</accession>
    <name>Q6FSR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G08492g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSR1"/>
    <dbReference type="STRING" id="284593.Q6FSR1"/>
    <dbReference type="KEGG" id="cgr:2888122"/>
    <dbReference type="CGD" id="CAL0129361">
        <property type="gene designation" value="CAGL0G08492g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08492g"/>
    <dbReference type="HOGENOM" id="CLU_515789_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSR1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding" evidence="1">
        <location>
            <begin position="282"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="528" mass="61427" checksum="09CF9B9ABC871D6B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT02</accession>
    <name>Q6FT02_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0G06446g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446642.1">
        <property type="nucleotide sequence ID" value="XM_446642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT02"/>
    <dbReference type="KEGG" id="cgr:2888175"/>
    <dbReference type="CGD" id="CAL0137523">
        <property type="gene designation" value="CAGL0G06446g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06446g"/>
    <dbReference type="HOGENOM" id="CLU_2196609_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT02"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0137523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="108" mass="12738" checksum="A6A2551750869BAC" modified="2004-07-19" version="1">MLILTTTWNHIARQDSCNHLSNRCMKCVISFYTLEDMLAIVNILDYTWYANAGVLRYAYQRTDSDVKPRLDSLYHPSPPHFGLEDKHTNIQTYKQHLSYTPPPRHQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT97</accession>
    <name>Q6FT97_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alpha-1,3-mannosyltransferase MNT3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0G04279g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446547.1">
        <property type="nucleotide sequence ID" value="XM_446547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT97"/>
    <dbReference type="CAZy" id="GT71">
        <property type="family name" value="Glycosyltransferase Family 71"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888078"/>
    <dbReference type="CGD" id="CAL0129204">
        <property type="gene designation" value="CAGL0G04279g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04279g"/>
    <dbReference type="eggNOG" id="ENOG502RZ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015387_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FT97"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0129204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="660" mass="76824" checksum="BCDB41E716D1715A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTB4</accession>
    <name>Q6FTB4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0G03861g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTB4"/>
    <dbReference type="FunCoup" id="Q6FTB4">
        <property type="interactions" value="375"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTB4"/>
    <dbReference type="KEGG" id="cgr:2888333"/>
    <dbReference type="CGD" id="CAL0130737">
        <property type="gene designation" value="CAGL0G03861g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03861g"/>
    <dbReference type="eggNOG" id="KOG2986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030279_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FTB4"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0130737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG59457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="310" mass="35778" checksum="C70AB182F10EAA00" modified="2004-07-19" version="1">MSQFLLRDARRSLLRPLRRCYSSNFSNQAIEIESGLQRELDGILNSFDAPITYAFGYGSGVFKQVGYDSTDKPQIDLILAVEDPVEFHSRNIKQNSHHYSSLKYFGPKVISRFQDVGAGIYFNPYANINGNEVKYGIVSMKRILNDLKNWESFYIAGRLQKPVKVLKTNPTIEHYNHLNLKAAATLAKHLISVKYPEKFDEFQFYKEITGLSYLGDIRYHLGAENPKKVENIVTKNFDKFRMYYKPIYEDVVVNNGYYLPPGFTLKNSLKKIQYRIQRTSLTQMLKGVATAGITKSVKYAWAKRMKSRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTI8</accession>
    <name>Q6FTI8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0G02167g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTI8"/>
    <dbReference type="FunCoup" id="Q6FTI8">
        <property type="interactions" value="1277"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTI8"/>
    <dbReference type="KEGG" id="cgr:2888008"/>
    <dbReference type="CGD" id="CAL0130715">
        <property type="gene designation" value="CAGL0G02167g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02167g"/>
    <dbReference type="eggNOG" id="KOG2121">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006220_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTI8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000065">
        <property type="entry name" value="Ribonuclease Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="11">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0130715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="826" mass="94344" checksum="5B495952AA022701" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTI9</accession>
    <name>Q6FTI9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0G02145g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTI9"/>
    <dbReference type="STRING" id="284593.Q6FTI9"/>
    <dbReference type="KEGG" id="cgr:2888062"/>
    <dbReference type="CGD" id="CAL0137547">
        <property type="gene designation" value="CAGL0G02145g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02145g"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_444920_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTI9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07596">
        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="135"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0137547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="529" mass="60906" checksum="418375D15F4E96C3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTL1</accession>
    <name>Q6FTL1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0G01672g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Component of the lid subcomplex of the 19S RC.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTL1"/>
    <dbReference type="FunCoup" id="Q6FTL1">
        <property type="interactions" value="1176"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTL1"/>
    <dbReference type="KEGG" id="cgr:2888370"/>
    <dbReference type="CGD" id="CAL0129520">
        <property type="gene designation" value="CAGL0G01672g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01672g"/>
    <dbReference type="eggNOG" id="KOG0687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031814_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FTL1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="211"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0129520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="417" mass="47554" checksum="84B28AB219E9828B" modified="2004-07-19" version="1">MVDDKKFNEEEDGEVQYVDPTVNKVPNYEASELAFVLTQDKLSSKHSEVLDKLMKLIEEEEMAPYYKYLAEEYVPQGGLLKFDKSLYDRLVEKNEQKIADFKKKIEEIEENDEGELERAQAWINLGEYYAQIGDRINAQETLEKALEKAISTGAKIDVMLTITRIGFFYNDQLFVKDRLAQTNAMIEKGGDWERRNRYKTYKGIHSLAIRDFKEAANLLVDSLATFTSIELTSYENIATYASVAGLFALERTDLKAKVVDSPDLLSLINTTPALQSISSLTISLYTSDYASYFPFLLETYDNVLIPSKYLNVHADYFVREMRRKVYAQLLESYKTLSLKSMASAFGVSVEFLDNDLGKFIPNRQLNCVIDRVNGIVETNRPDNKNAQYSLLVKQGDGLLTKLQKYGAAVRLTGSDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTM5</accession>
    <name>Q6FTM5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0G01320g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTM5"/>
    <dbReference type="FunCoup" id="Q6FTM5">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTM5"/>
    <dbReference type="KEGG" id="cgr:2888054"/>
    <dbReference type="CGD" id="CAL0130336">
        <property type="gene designation" value="CAGL0G01320g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01320g"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036115_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTM5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="191"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="252"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0130336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="438" mass="48694" checksum="52C3E0F6E23FB5F9" modified="2004-07-19" version="1">MSELTSSGGPRSLQNRNTKNLSIAIEHQKPELTSLQEIPEVRPQMQSNFSSGTIYRRSTLDSDKSVRKPGNTIYSVTPKLDRVQSASPIYASSMEIDNKKKLGRVHSLSLSIKTKNLPTRNSNSLKSGHIRNRSFTMSGAETSTPLITDESESRNLKKEFMNKVGSRVQQQDFDMDAMYSEIYQNTAYTEGPLLVVEPSIYLYSEPNLSVILNYDVVINVAKEIDNLKQHIPAGMAIDYYHVPWTHASQISKDLAWLTEVMHTAVTKGKKILVHCQCGVSRSASLIVGYMMRYENLALNDAYAKLKEIAKDISPNMGLIFQLMEWNDMLPSLRNNEASSKTTVQSMDMSQNIPLETTKNVSTSKFDNSSYGMSSSITISDTTSGNSPSSANSISLQNESFPVLNSKELTLTDLSNNNILNGSYKNAADVVADSSQLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTP7</accession>
    <name>Q6FTP7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin biosynthesis protein CHS5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CHS5</name>
        <name evidence="8 9" type="ordered locus">CAGL0G00814g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446397.1">
        <property type="nucleotide sequence ID" value="XM_446397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTP7"/>
    <dbReference type="FunCoup" id="Q6FTP7">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTP7"/>
    <dbReference type="GeneID" id="2888154"/>
    <dbReference type="KEGG" id="cgr:2888154"/>
    <dbReference type="CGD" id="CAL0129391">
        <property type="gene designation" value="CHS5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00814g"/>
    <dbReference type="eggNOG" id="KOG1181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019904_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FTP7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000282">
        <property type="term" value="P:cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17742">
        <property type="entry name" value="BRCT_CHS5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000077">
        <property type="entry name" value="Chitin biosynthesis protein CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031673">
        <property type="entry name" value="Chs5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052827">
        <property type="entry name" value="CHS_Export/Cell_Fusion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031669">
        <property type="entry name" value="Fn3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47351:SF1">
        <property type="entry name" value="CHITIN BIOSYNTHESIS PROTEIN CHS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16892">
        <property type="entry name" value="CHS5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16893">
        <property type="entry name" value="fn3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="78"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="166"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="429"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="582" mass="64166" checksum="E0D9A76D8CB94EC9" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTR3</accession>
    <name>Q6FTR3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0G00374g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTR3"/>
    <dbReference type="FunCoup" id="Q6FTR3">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTR3"/>
    <dbReference type="KEGG" id="cgr:2888091"/>
    <dbReference type="CGD" id="CAL0129173">
        <property type="gene designation" value="CAGL0G00374g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00374g"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008679_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FTR3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002107">
        <property type="term" value="P:generation of mature 3'-end of 5S rRNA generated by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042780">
        <property type="term" value="P:tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="9">
        <location>
            <begin position="330"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0129173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="660" mass="74090" checksum="391BF5B77809973D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTS3</accession>
    <name>Q6FTS3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0G00154g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTS3"/>
    <dbReference type="FunCoup" id="Q6FTS3">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTS3"/>
    <dbReference type="KEGG" id="cgr:2888412"/>
    <dbReference type="CGD" id="CAL0137601">
        <property type="gene designation" value="CAGL0G00154g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00154g"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019916_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTS3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="97"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0137601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="433" mass="49189" checksum="933E1AD2BC354FB7" modified="2004-07-19" version="1">MFTLPALTRDITVEVNTSAQKSSAVRRPIEPVGKYFMHHAQRTLRNHTWSEFEKLQAEQNVKKVDESNVDPDEALFDQEIADVSLLTHDPRDWKTADLYAAMGLSKLRFRATENQIIKSHRKQVVKYHPDKQSAHGAGLDQDGFFKIIQKSFETLTDVTKRRQYDSCDFNADVLPPKKGTDYDFYEAWGPVFEAEARFSKKTPVPSLGDAKSTKKEVEAFYSFWHRFDSWRTFEFLDEDVPDDSSNRDHKRYIERKNKAARDKKKTADNARLVKLVERALSEDPRIKQFKEEEKKEKERKKWEKEAGSRAEAEAKAKAEAEAKAKAEAEAQEAALAKADKKKAKEAAKAAKKKNKRAIRNLPKESDYFGDSDKASAIDEQVGLIVDSIVDEELVEIAGKIKASPADGKVVLQEAAKKLSDSGKLPASLLSYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTU5</accession>
    <name>Q6FTU5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0F08745g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTU5"/>
    <dbReference type="FunCoup" id="Q6FTU5">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTU5"/>
    <dbReference type="KEGG" id="cgr:2887776"/>
    <dbReference type="CGD" id="CAL0131378">
        <property type="gene designation" value="CAGL0F08745g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08745g"/>
    <dbReference type="eggNOG" id="ENOG502S4WH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_186295_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTU5"/>
    <dbReference type="OMA" id="KWTVHES"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="86" mass="9736" checksum="B6A48709B917C19E" modified="2004-07-19" version="1">MTRTNKWTVHEAKANARYFTRNGNFGESPNSVKREGSGKGNWGKPGDEINDLIDAGEIPPIFNKQRRGSNNQQNEHKLGKVQNREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU01</accession>
    <name>Q6FU01_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0F07491g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU01"/>
    <dbReference type="FunCoup" id="Q6FU01">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU01"/>
    <dbReference type="KEGG" id="cgr:2887837"/>
    <dbReference type="CGD" id="CAL0131022">
        <property type="gene designation" value="CAGL0F07491g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07491g"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_13_1_1"/>
    <dbReference type="InParanoid" id="Q6FU01"/>
    <dbReference type="OMA" id="HDQASTN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120155">
        <property type="term" value="C:MIH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032038">
        <property type="term" value="F:myosin II heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903476">
        <property type="term" value="P:protein localization to cell division site involved in mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006903">
        <property type="term" value="P:vesicle targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000082">
        <property type="entry name" value="Myosin light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="73"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0131022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="141" mass="15725" checksum="D2A7F0A41C59D5B0" modified="2004-07-19" version="1">MSQNKDIFTLFDKKGQGSIPKDVVGDYLRAIGYNPTNKQVTEILSGSGEALTLPEVEELVKKNEAMLDATTKGKLEDFVKAFQVFDKDNTGKVSVGDLRYMLTGLGEKLTDEEVDELLKGIEVDSEGQIDYKKFIEDVLRQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU02</accession>
    <name>RMD9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein RMD9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RMD9</name>
        <name type="ordered locus">CAGL0F07469g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the 3'-UTR of mitochondrial mRNAs. Involved in the processing or stability of mitochondrial mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated. Phosphorylation promotes binding to RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RMD9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446292.1">
        <property type="nucleotide sequence ID" value="XM_446292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU02"/>
    <dbReference type="SMR" id="Q6FU02"/>
    <dbReference type="STRING" id="284593.Q6FU02"/>
    <dbReference type="EnsemblFungi" id="CAGL0F07469g-T">
        <property type="protein sequence ID" value="CAGL0F07469g-T-p1"/>
        <property type="gene ID" value="CAGL0F07469g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887885"/>
    <dbReference type="KEGG" id="cgr:2887885"/>
    <dbReference type="CGD" id="CAL0131290">
        <property type="gene designation" value="CAGL0F07469g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_F07469g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07469g"/>
    <dbReference type="eggNOG" id="ENOG502QUSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019840_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU02"/>
    <dbReference type="OMA" id="DCVFQTL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070935">
        <property type="term" value="P:3'-UTR-mediated mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090615">
        <property type="term" value="P:mitochondrial mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903108">
        <property type="term" value="P:regulation of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0749">Sporulation</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000301783" description="RNA-binding protein RMD9, mitochondrial">
        <location>
            <begin position="38"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="616" mass="71001" checksum="48E9BFFD4F41F4FC" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU45</accession>
    <name>RNA14_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RNA14</name>
        <name type="ordered locus">CAGL0F06479g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Nucleus and/or cytoplasm.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446249.1">
        <property type="nucleotide sequence ID" value="XM_446249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU45"/>
    <dbReference type="SMR" id="Q6FU45"/>
    <dbReference type="FunCoup" id="Q6FU45">
        <property type="interactions" value="1279"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU45"/>
    <dbReference type="EnsemblFungi" id="CAGL0F06479g-T">
        <property type="protein sequence ID" value="CAGL0F06479g-T-p1"/>
        <property type="gene ID" value="CAGL0F06479g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887866"/>
    <dbReference type="KEGG" id="cgr:2887866"/>
    <dbReference type="CGD" id="CAL0129762">
        <property type="gene designation" value="CAGL0F06479g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_F06479g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06479g"/>
    <dbReference type="eggNOG" id="KOG1914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007630_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FU45"/>
    <dbReference type="OMA" id="PKRQYFK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072423">
        <property type="term" value="P:response to DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <feature type="chain" id="PRO_0000238521" description="mRNA 3'-end-processing protein RNA14">
        <location>
            <begin position="1"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 1">
        <location>
            <begin position="46"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 2">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 3">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 4">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 5">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="HAT 6">
        <location>
            <begin position="290"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="571"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="646" mass="76307" checksum="056196438D2D2795" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU55</accession>
    <name>Q6FU55_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PWWP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0F06215g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU55"/>
    <dbReference type="FunCoup" id="Q6FU55">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU55"/>
    <dbReference type="KEGG" id="cgr:2887688"/>
    <dbReference type="CGD" id="CAL0130904">
        <property type="gene designation" value="CAGL0F06215g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06215g"/>
    <dbReference type="eggNOG" id="ENOG502QTTV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031574_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU55"/>
    <dbReference type="OMA" id="WPAMIIP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036437">
        <property type="term" value="C:Isw1b complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05840">
        <property type="entry name" value="PWWP_ScIOC4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IOC4-like_PWWP"/>
    </dbReference>
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        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="2">
        <location>
            <begin position="7"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0130904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="449" mass="52138" checksum="52D63083620FD37D" modified="2004-07-19" version="1">MPNIYQPTDVVLAKVKGFPAWPAMVIPKELIPENVWKIRSRISVDKAETKEDQDSTPDEEFGSDYDPNDYIIYSKVLKFKKNKEQPSLYCVKFMCDDSYIWVKQSDMQPLSVEECQEWLASKTKKNKKLIPAYEMAMKGSSGIDVWEFVEYGSMGKPDEDEYIEDDFEEPATTRRSRSKNAKIKPMRSSSRQRKKLESSVDEDDIGEAGRRTRTRAKQTNSKRDQLHALEDIIETPNKRTRKEQISKKVQTKKTKAIKPKIPEKEYYKYEDDDDWSIVGLGPQETEIGKCLSAVVKKSISKKSGDRHSEMKLDLEDKILSINKLLEVSLYKMIKNDQNQDDSLKNDLELIADEIAVALNIKGSMTEFLTVFNSNNQLIMNYRLLMNLGKKDLEKWNLWDDFQSFFQTIYDCAFIPDSHQWEVPLEEDTNNEVQPPNEVKESIQEEILAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUA9</accession>
    <name>Q6FUA9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0F04917g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUA9"/>
    <dbReference type="FunCoup" id="Q6FUA9">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUA9"/>
    <dbReference type="CAZy" id="CBM21">
        <property type="family name" value="Carbohydrate-Binding Module Family 21"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887862"/>
    <dbReference type="CGD" id="CAL0131352">
        <property type="gene designation" value="CAGL0F04917g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04917g"/>
    <dbReference type="eggNOG" id="KOG3986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014598_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUA9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF51">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT GAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="172"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="682" mass="77815" checksum="DDCACEEE022AF71B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUI1</accession>
    <name>Q6FUI1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exosome complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0F03289g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the C1D family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUI1"/>
    <dbReference type="FunCoup" id="Q6FUI1">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUI1"/>
    <dbReference type="KEGG" id="cgr:2887626"/>
    <dbReference type="CGD" id="CAL0131380">
        <property type="gene designation" value="CAGL0F03289g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03289g"/>
    <dbReference type="eggNOG" id="KOG4835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101423_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FUI1"/>
    <dbReference type="OMA" id="FQGTHTK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011082">
        <property type="entry name" value="Exosome-assoc_fac/DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341:SF3">
        <property type="entry name" value="NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15341">
        <property type="entry name" value="SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0131380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="149" mass="17529" checksum="C4D1046ACCC1382B" modified="2004-07-19" version="1">MSEEIKSIRPYIKQLDKRLAELTELVQDYASPLEETLVKETDELKRLKTTNNYAYILASLMFSYVKLLSGHDTQHLNEKVMVELQRVRGYIERTKKLENKLKNKVSEQELKQETVKSQIRKTLGQPTISKQNFKNKHIKFEESSKVSKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUM5</accession>
    <name>YPI1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Type 1 phosphatases regulator YPI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">YPI1</name>
        <name type="ordered locus">CAGL0F02255g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446069.1">
        <property type="nucleotide sequence ID" value="XM_446069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUM5"/>
    <dbReference type="SMR" id="Q6FUM5"/>
    <dbReference type="FunCoup" id="Q6FUM5">
        <property type="interactions" value="177"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUM5"/>
    <dbReference type="EnsemblFungi" id="CAGL0F02255g-T">
        <property type="protein sequence ID" value="CAGL0F02255g-T-p1"/>
        <property type="gene ID" value="CAGL0F02255g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887827"/>
    <dbReference type="KEGG" id="cgr:2887827"/>
    <dbReference type="CGD" id="CAL0129177">
        <property type="gene designation" value="CAGL0F02255g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_F02255g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02255g"/>
    <dbReference type="eggNOG" id="KOG4102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098333_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FUM5"/>
    <dbReference type="OMA" id="AYEVQPH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005977">
        <property type="term" value="P:glycogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900180">
        <property type="term" value="P:regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000333471" description="Type 1 phosphatases regulator YPI1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="146" mass="17038" checksum="386AC0ACFF15EF17" modified="2004-07-19" version="1">MNQVSEGSRTVSVEEMPRVLQLRAANTNITEGESTSQSRNVRWEEDVVDNENMNKKKTKICCIFHPAQEEEDPEQLCPSDHEHSSSSSSSSSSESDDDDKYNSEQRRQRRIERRRRRQKTNRPASPNAYEIQPDYSEYRKRMNANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUW2</accession>
    <name>Q6FUW2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low-affinity Fe(2+) transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FET4</name>
        <name evidence="2 3" type="ordered locus">CAGL0F00187g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445982.1">
        <property type="nucleotide sequence ID" value="XM_445982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUW2"/>
    <dbReference type="FunCoup" id="Q6FUW2">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUW2"/>
    <dbReference type="GeneID" id="2887595"/>
    <dbReference type="KEGG" id="cgr:2887595"/>
    <dbReference type="CGD" id="CAL0129949">
        <property type="gene designation" value="FET4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00187g"/>
    <dbReference type="eggNOG" id="ENOG502QRCK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028340_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUW2"/>
    <dbReference type="OMA" id="WQVVMQD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007251">
        <property type="entry name" value="Iron_permease_Fet4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04120">
        <property type="entry name" value="Iron_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="64955" checksum="9B6A3CCCBED6260B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV75</accession>
    <name>ALG14_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ALG14</name>
        <name type="ordered locus">CAGL0E04180g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ALG14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445869.1">
        <property type="nucleotide sequence ID" value="XM_445869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV75"/>
    <dbReference type="FunCoup" id="Q6FV75">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV75"/>
    <dbReference type="EnsemblFungi" id="CAGL0E04180g-T">
        <property type="protein sequence ID" value="CAGL0E04180g-T-p1"/>
        <property type="gene ID" value="CAGL0E04180g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887310"/>
    <dbReference type="KEGG" id="cgr:2887310"/>
    <dbReference type="CGD" id="CAL0128750">
        <property type="gene designation" value="CAGL0E04180g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_E04180g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04180g"/>
    <dbReference type="eggNOG" id="KOG3339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064541_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FV75"/>
    <dbReference type="OMA" id="GTCCIIT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098548">
        <property type="term" value="C:cytoplasmic side of Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000123812" description="UDP-N-acetylglucosamine transferase subunit ALG14">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="6"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="25"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P38242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="242" mass="27335" checksum="9EA27118E191F599" modified="2004-07-19" version="1">MPFLSTAHLCALLLILGCFYIGRLIKVIPILRFACAGEAEIKPLFIQPKSNDGIHLFVFLGSGGHTGEMLRLLQNHQEVLLNKRNTFYIGYSDDDSKARFLSMVEKYDFKAERIHFYPFAKAREVNAGPIASIVTISKTLLTGFTNVLSIKMNTLGQPHLTLLNGPGTCCIINFWLKLLEWLIYIPYLSNGSNVVYIESLARIESLSLTGKILYLLADVFVVQWEELKVRKAPRSEYYGILV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-02-28" modified="2025-04-09" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV98</accession>
    <name>TPO12_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multidrug transporter TPO1_2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Clotrimazole exporter TPO1_2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Drug:H(+) antiporter TPO1_2</fullName>
            <shortName evidence="6">DHA TPO1_2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TPO1_2</name>
        <name type="ordered locus">CAGL0E03674g</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Mol. Cell. Proteomics" volume="15" first="57" last="72">
            <title>Membrane proteome-wide response to the antifungal drug clotrimazole in Candida glabrata: role of the transcription factor CgPdr1 and the drug:H+ antiporters CgTpo1_1 and CgTpo1_2.</title>
            <authorList>
                <person name="Pais P."/>
                <person name="Costa C."/>
                <person name="Pires C."/>
                <person name="Shimizu K."/>
                <person name="Chibana H."/>
                <person name="Teixeira M.C."/>
            </authorList>
            <dbReference type="PubMed" id="26512119"/>
            <dbReference type="DOI" id="10.1074/mcp.M114.045344"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2017" name="Cell. Microbiol." volume="19" first="0" last="0">
            <title>The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata.</title>
            <authorList>
                <person name="Santos R."/>
                <person name="Costa C."/>
                <person name="Mil-Homens D."/>
                <person name="Romao D."/>
                <person name="de Carvalho C.C."/>
                <person name="Pais P."/>
                <person name="Mira N.P."/>
                <person name="Fialho A.M."/>
                <person name="Teixeira M.C."/>
            </authorList>
            <dbReference type="PubMed" id="27780306"/>
            <dbReference type="DOI" id="10.1111/cmi.12686"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Multidrug resistance transporter involved in resistance to azole antifungal drugs such as the imidazoles miconazole, ketoconazole, and tioconazole; as well as the triazoles itraconazole and fluconazole (PubMed:26512119). Also plays a role in the resistance to other antifungal drug families such as the polyene amphotericin B, the pyrimide analog flucytosine, the fungicide mancozeb, and the polyamine spermine (PubMed:26512119). Decreases the intracellular accumulation of clotrimazole by mediating its extrusion from cells (PubMed:26512119). Plays a role in biofilm formation (PubMed:27780306).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4 5">Expression is up-regulated by clotrimazole (PubMed:26512119). Expression is also up-regulated during biofilm formation (PubMed:27780306).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 5">Leads to intracellular accumulation of clotrimazole and increases the susceptibility to clotrimazole but also to other imidazoles such as miconazole, ketoconazole, and tioconazole; as well as triazoles such as itraconazole and fluconazole (PubMed:26512119). Also increases susceptibility to other antifungal drug families such as the polyene amphotericin B, the pyrimide analog flucytosine, the fungicide mancozeb, and the polyamine spermine (PubMed:26512119). Decreases virulence in a Galleria mellonella model of infection, limits the survival when exposed to phagocytosis and impairs biofilm formation by decreasing the expression ofthe adhesin encoding genes ALS1, EAP1, and EPA1 (PubMed:27780306).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445846.1">
        <property type="nucleotide sequence ID" value="XM_445846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV98"/>
    <dbReference type="SMR" id="Q6FV98"/>
    <dbReference type="STRING" id="284593.Q6FV98"/>
    <dbReference type="GlyCosmos" id="Q6FV98">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0E03674g-T">
        <property type="protein sequence ID" value="CAGL0E03674g-T-p1"/>
        <property type="gene ID" value="CAGL0E03674g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887382"/>
    <dbReference type="KEGG" id="cgr:2887382"/>
    <dbReference type="CGD" id="CAL0128758">
        <property type="gene designation" value="TPO1_2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_E03674g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E03674g"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="InParanoid" id="Q6FV98"/>
    <dbReference type="OMA" id="AQNWPLR"/>
    <dbReference type="PHI-base" id="PHI:6626"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044010">
        <property type="term" value="P:single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000443415" description="Multidrug transporter TPO1_2">
        <location>
            <begin position="1"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="26512119"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="27780306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="26512119"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
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    <sequence length="577" mass="63342" checksum="7A864FFFAE95BD26" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVG5</accession>
    <name>CSN10_CANGA</name>
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        <recommendedName>
            <fullName>COP9 signalosome complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RRI2</name>
        <name type="synonym">CSN10</name>
        <name type="ordered locus">CAGL0E02057g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <text evidence="1">Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response.</text>
    </comment>
    <comment type="subunit">
        <text>Component of a COP9 signalosome-like (CSN) complex.</text>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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            <begin position="1"/>
            <end position="643"/>
        </location>
    </feature>
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        <location>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVQ2</accession>
    <name>Q6FVQ2_CANGA</name>
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        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="9 10" type="ordered locus">CAGL0D06600g</name>
    </gene>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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            <taxon>Saccharomycetales</taxon>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0043484">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
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    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="CLK_kinases"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="286"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0127995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="725" mass="82703" checksum="2ABC29943BE90591" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVT6</accession>
    <name>Q6FVT6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sporulation-specific protein 75</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0D05720g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVT6"/>
    <dbReference type="FunCoup" id="Q6FVT6">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886991"/>
    <dbReference type="CGD" id="CAL0128213">
        <property type="gene designation" value="CAGL0D05720g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05720g"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FVT6"/>
    <dbReference type="OMA" id="PITNEIW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="679"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="747"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="57"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="490"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0128213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="881" mass="101786" checksum="903B98469EB058F7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVY0</accession>
    <name>Q6FVY0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0D04642g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVY0"/>
    <dbReference type="FunCoup" id="Q6FVY0">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVY0"/>
    <dbReference type="KEGG" id="cgr:2887087"/>
    <dbReference type="CGD" id="CAL0127957">
        <property type="gene designation" value="CAGL0D04642g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D04642g"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_12_4_1"/>
    <dbReference type="InParanoid" id="Q6FVY0"/>
    <dbReference type="OMA" id="KNAEMFM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010696">
        <property type="term" value="P:positive regulation of mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="169"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="262"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="266"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0127957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="399" mass="46317" checksum="B2E85487074C5FA4" modified="2004-07-19" version="1">MSSMSSSSMDSAQRKPSEDEKMDRPALTNVEVNRALPGGRKAQPLTEQEKKRHPMYRKPSRIRREDSDASYMANSKKRQVFQDNADDDEPTGKDQESRIKRAKVQDRQIKWVDLDSKEKNNIAMVVEYTNDIFDFLYEREKNTIPMHNYLLDRKSKYHLRPATRAVLVDWLVEVHDKFQCYPETLYLGINIMDRFLSQHKVDINKLQLLAVTSLFIAAKFEEINLPKLSEYAYITDGAASKDDIKVSEMFILTELKFSLDWPNPLNFLRRLSKADGYDGECRMIAKFILEYSLCSSKFVGEKPSELAAMAIFLARRILKRESPIWDDTFIHYSGGIDALNDNHFQNLCTIMINEIAQPATKLTALCDKYKSIKGGTIYDKTIKWCKDQMERNYENVFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW37</accession>
    <name>Q6FW37_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0D03234g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW37"/>
    <dbReference type="FunCoup" id="Q6FW37">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW37"/>
    <dbReference type="KEGG" id="cgr:2886990"/>
    <dbReference type="CGD" id="CAL0128007">
        <property type="gene designation" value="CAGL0D03234g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03234g"/>
    <dbReference type="eggNOG" id="KOG1605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020262_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FW37"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903293">
        <property type="term" value="C:phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="4">
        <location>
            <begin position="236"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0128007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG58468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="410" mass="46050" checksum="5D30FA307BD5AE9D" modified="2004-07-19" version="1">MGFISALFCCSSNSTTDSITTKQITSQNNNRDTSNTDPEKYHQNVKMMTYNNTTTLTPERDSSLNKHNNSSSPQIADINASKRPRTTPDISANPQNNNIPQVNVPDDALSRSSSDSGQQRILKGSWTIGGEDEKMDDHTHLKIHGDEDMGEMSNEKTTINESNSELDRSTQSSSEMTYQPTDNQGGIITSVYDNDVDMDRDVTPPYDEPYVDLAALQEDQYHAPGYNTLLPPQTEQFKGKKCLVLDLDETLVHSSFKYLRTADFVLPVNIDDQVHNVYVIKRPGVDEFLKRVGELYEVVVFTASVARYGDPLLDILDQHKSIHHRLFREACYNYEGNYIKNLSQIGRPLSEIIILDNSPASYIFHPQHAIPVSSWFSDSHDNELIDIVPLLEDLSSNSVLDVGKVLDVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW72</accession>
    <name>Q6FW72_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0D02464g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW72"/>
    <dbReference type="FunCoup" id="Q6FW72">
        <property type="interactions" value="813"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW72"/>
    <dbReference type="KEGG" id="cgr:2887140"/>
    <dbReference type="CGD" id="CAL0128501">
        <property type="gene designation" value="CAGL0D02464g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02464g"/>
    <dbReference type="eggNOG" id="KOG1888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003016_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FW72"/>
    <dbReference type="OMA" id="KRKCCAH"/>
    <dbReference type="PHI-base" id="PHI:9271"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="181"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0128501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="871" mass="100942" checksum="E90D2EE458EB32DA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWB3</accession>
    <name>Q6FWB3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="5">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0D01518g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="5"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWB3"/>
    <dbReference type="FunCoup" id="Q6FWB3">
        <property type="interactions" value="1277"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWB3"/>
    <dbReference type="KEGG" id="cgr:2887237"/>
    <dbReference type="CGD" id="CAL0128323">
        <property type="gene designation" value="CAGL0D01518g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01518g"/>
    <dbReference type="eggNOG" id="KOG2015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_13_0_1"/>
    <dbReference type="InParanoid" id="Q6FWB3"/>
    <dbReference type="OMA" id="HIIEYVI"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120123">
        <property type="term" value="C:ubiquitin activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="3"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="4">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0128323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="297" mass="32885" checksum="EC54E47B8750F655" modified="2004-07-19" version="1">MAMKVLVLGAGGLGCELLKNLARYDYVSEIHVVDLDTIELSNLNRQFLFREQDIGKYKAEVAAHAIGKRVTDKVIVPHVTDLTTLDATFYSQFQFVISGLDAIAPRRYVNQVLVDITRASAFEICIPFIDGGVEGLKGHIKTIIPGINACWECSIDTLPHESAMNNPMCTVANNPRSLEHIVEYVVLISNPDADLDDLAVCTQLLDQCRQRASQYGIDCSELTLSKMAGIAKRVIPTVSTTNSIVAAMCCEQLNCIYRDLWDPESSPNFTTINGAEGMYIFSFQYQRNPECTVCSML</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWF4</accession>
    <name>RL31_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein eL31</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPL31</name>
        <name type="ordered locus">CAGL0D00616g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWF4"/>
    <dbReference type="SMR" id="Q6FWF4"/>
    <dbReference type="FunCoup" id="Q6FWF4">
        <property type="interactions" value="990"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWF4"/>
    <dbReference type="EnsemblFungi" id="CAGL0D00616g-T">
        <property type="protein sequence ID" value="CAGL0D00616g-T-p1"/>
        <property type="gene ID" value="CAGL0D00616g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887139"/>
    <dbReference type="CGD" id="CAL0128133">
        <property type="gene designation" value="CAGL0D00616g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_D00616g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00616g"/>
    <dbReference type="eggNOG" id="KOG0893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112570_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FWF4"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000153784" description="Large ribosomal subunit protein eL31">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="113" mass="12976" checksum="31B7877C5005DA4A" modified="2004-07-19" version="1">MAGLKDVVTREYTINMHKRLHGVSFKKRAPKAVKEIKKFAKLHMGTEDVRLAPELNQEIWKRGVKGVAFRLRLRISRKRNEEENAKNPLFSYVEPVFVASAKGLQTTVVEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWJ5</accession>
    <name>Q6FWJ5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PRS5</name>
        <name evidence="14 15" type="ordered locus">CAGL0C05181g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445399.1">
        <property type="nucleotide sequence ID" value="XM_445399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWJ5"/>
    <dbReference type="FunCoup" id="Q6FWJ5">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWJ5"/>
    <dbReference type="GeneID" id="2886791"/>
    <dbReference type="KEGG" id="cgr:2886791"/>
    <dbReference type="CGD" id="CAL0127250">
        <property type="gene designation" value="PRS5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05181g"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FWJ5"/>
    <dbReference type="OMA" id="TCDLHES"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000076">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0127250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="481" mass="51706" checksum="A92ADC00D60231AC" modified="2004-07-19" version="1">MSNIVIFGGDSHPDLVKRICENLDIEPAKVTLGKFSNGETSVQLGSSVREKDVYVIQSGCGHVNDTFLQLLILISACKSSSASRVTAVMPYFCYSRQPDIPYTVKGAPIISNPKESNPTDSRPGTPGFKLMTQKPGSESPFKSLDTAIRSTIHMENPQPMRKPAPPTPQMSQSRIPVIPGGKAQPPSGSSNDAGEMFNAQNAGYKLWVVQAGTLIANLLTAAGADHVITMDLHDPQFPGFFDIPVDNLYCKPIVQGYIKHEIPDYKDAVIVSPDAGGAKRATAIADALELSFALIHKERRSQLLKGPPDASLSSGGGVPLSPKPLVANLNNASIAGPSSTEMRRSSSSASIHSNASQSSASKYIQTTMLVGDVRDKVCIIIDDLVDTSYTINRAAKLLKDQGAKKVYAIITHGIFSGDALTRIRSSKIDKLVISNSVPQDRTVSILGKDRVDVIDVSKVFGEAIRRIHNGESISMLFEHGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX25</accession>
    <name>Q6FX25_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EPA8</name>
        <name evidence="4 5" type="ordered locus">CAGL0C00847g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445219.1">
        <property type="nucleotide sequence ID" value="XM_445219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX25"/>
    <dbReference type="STRING" id="284593.Q6FX25"/>
    <dbReference type="GeneID" id="2886801"/>
    <dbReference type="KEGG" id="cgr:2886801"/>
    <dbReference type="CGD" id="CAL0127446">
        <property type="gene designation" value="EPA8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00847g"/>
    <dbReference type="eggNOG" id="ENOG502S8JT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355247_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX25"/>
    <dbReference type="OMA" id="HINDTPC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48184:SF1">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48184">
        <property type="entry name" value="RICIN B-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273671" description="PA14 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="91"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0127446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="790" mass="82834" checksum="49C4C7CFE83FD96A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX67</accession>
    <name>Q6FX67_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0B00396g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57887.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX67"/>
    <dbReference type="FunCoup" id="Q6FX67">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX67"/>
    <dbReference type="KEGG" id="cgr:2886607"/>
    <dbReference type="CGD" id="CAL0126988">
        <property type="gene designation" value="CAGL0B00396g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B00396g"/>
    <dbReference type="eggNOG" id="KOG4604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068905_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FX67"/>
    <dbReference type="OMA" id="DEHGRKW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0126988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG57887.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="88" mass="9633" checksum="F3152899108FB454" modified="2008-09-23" version="2">MSNKEETKAKTVDYTPVRSILNDKWDVVLSNMIVKMGLGFGVGVVTSVLFFKRRSFPVWLGVGFGAGRGYSEGDAIFRSTAGLRSVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXD4</accession>
    <name>Q6FXD4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0B01815g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXD4"/>
    <dbReference type="FunCoup" id="Q6FXD4">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXD4"/>
    <dbReference type="KEGG" id="cgr:2886603"/>
    <dbReference type="CGD" id="CAL0127038">
        <property type="gene designation" value="CAGL0B01815g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01815g"/>
    <dbReference type="eggNOG" id="KOG1569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FXD4"/>
    <dbReference type="OMA" id="KTHFKIW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0127038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG57948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="31663" checksum="AAD490D2F6647CED" modified="2004-07-19" version="1">MLRIGSKVRYCNANRVIFNSALFGRRLLATEAAPIPQAAAPTLTKEQAKKREMKRLALKKAEAKKPANIHPLYMPIPLALRYLRSAEVGRPTQHQTITVTTLVVADKGNAALAGNILFPHPLKQMKIAIFSSNKEKLDELKSKYSKQVKIAGGEDMIADIKSGKIKVDGVNKVFATPEIFPTIASQLGRVLGPKGLMPNLKKQHQNTVGEDLDSLIEENLGQVSFRQRGNSLSVSVGRCNFSDRDILENIIAVRNAFKQSVSSQVAKKPSILGKTTISTTAGPGIVIDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXH2</accession>
    <name>Q6FXH2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-mannosyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BMT3</name>
        <name evidence="6 7" type="ordered locus">CAGL0B02926g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BMT family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445099.1">
        <property type="nucleotide sequence ID" value="XM_445099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXH2"/>
    <dbReference type="STRING" id="284593.Q6FXH2"/>
    <dbReference type="CAZy" id="GT91">
        <property type="family name" value="Glycosyltransferase Family 91"/>
    </dbReference>
    <dbReference type="GeneID" id="2886504"/>
    <dbReference type="KEGG" id="cgr:2886504"/>
    <dbReference type="CGD" id="CAL0127692">
        <property type="gene designation" value="BMT3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B02926g"/>
    <dbReference type="eggNOG" id="ENOG502QTZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013841_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FXH2"/>
    <dbReference type="OMA" id="DWKGPED"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021988">
        <property type="entry name" value="BMT1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12141">
        <property type="entry name" value="BMT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0127692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG57999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="618" mass="71311" checksum="C7CFEFF035493FEA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXN3</accession>
    <name>POA1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ADP-ribose 1''-phosphate phosphatase</fullName>
            <ecNumber>3.1.3.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">POA1</name>
        <name type="ordered locus">CAGL0B04411g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ADP-alpha-D-ribose 1''-phosphate + H2O = ADP-D-ribose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="ChEBI" id="CHEBI:58753"/>
            <dbReference type="EC" id="3.1.3.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the POA1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.84"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445162.1">
        <property type="nucleotide sequence ID" value="XM_445162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXN3"/>
    <dbReference type="SMR" id="Q6FXN3"/>
    <dbReference type="FunCoup" id="Q6FXN3">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXN3"/>
    <dbReference type="EnsemblFungi" id="CAGL0B04411g-T">
        <property type="protein sequence ID" value="CAGL0B04411g-T-p1"/>
        <property type="gene ID" value="CAGL0B04411g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886571"/>
    <dbReference type="KEGG" id="cgr:2886571"/>
    <dbReference type="CGD" id="CAL0127810">
        <property type="gene designation" value="CAGL0B04411g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04411g"/>
    <dbReference type="eggNOG" id="ENOG502S60W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054419_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FXN3"/>
    <dbReference type="OMA" id="CQGSWGK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047407">
        <property type="term" value="F:ADP-ribosyl-[dinitrogen reductase] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140291">
        <property type="term" value="P:peptidyl-glutamate ADP-deribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02901">
        <property type="entry name" value="Macro_Poa1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050892">
        <property type="entry name" value="ADP-ribose_metab_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521:SF0">
        <property type="entry name" value="ADP-RIBOSE GLYCOHYDROLASE OARD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12521">
        <property type="entry name" value="PROTEIN C6ORF130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0904">Protein phosphatase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000324905" description="ADP-ribose 1''-phosphate phosphatase">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Macro" evidence="2">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="179" mass="19982" checksum="9B24E3DE8759C2E4" modified="2004-07-19" version="1">MSNIHYIKGNILKGRTYKRIIIHSCNANGAWGGGIAYQLAVKHPKAEEVYVDLCERFGQKLLGKCVVIPSYSDDDVLIGCLFTSIFGGASHGSGTSIVDYTDKALSHFDELLAKEQSKSDNANLDKEIEKLLKLKSGVLKDYKLEMPKINSGIFGVPWPETEEVLKKYDRSMNFTVYEL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXQ5</accession>
    <name>GPI14_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>GPI mannosyltransferase 1</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GPI mannosyltransferase I</fullName>
            <shortName>GPI-MT-I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Glycosylphosphatidylinositol-anchor biosynthesis protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GPI14</name>
        <name type="ordered locus">CAGL0B03905g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text>Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445140.1">
        <property type="nucleotide sequence ID" value="XM_445140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXQ5"/>
    <dbReference type="SMR" id="Q6FXQ5"/>
    <dbReference type="FunCoup" id="Q6FXQ5">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXQ5"/>
    <dbReference type="CAZy" id="GT50">
        <property type="family name" value="Glycosyltransferase Family 50"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0B03905g-T">
        <property type="protein sequence ID" value="CAGL0B03905g-T-p1"/>
        <property type="gene ID" value="CAGL0B03905g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886715"/>
    <dbReference type="KEGG" id="cgr:2886715"/>
    <dbReference type="CGD" id="CAL0127722">
        <property type="gene designation" value="CAGL0B03905g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03905g"/>
    <dbReference type="eggNOG" id="KOG3893">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024220_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FXQ5"/>
    <dbReference type="OMA" id="LINCWIL"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180041">
        <property type="term" value="F:dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000246227" description="GPI mannosyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="431" mass="50244" checksum="41CD6DAA67BF7C0B" modified="2004-07-19" version="1">MFKLGTIGLLSLAVLLRIAFFLFGVYQDEHFTVKYTDIDYQVFNDAAWFVAHRKSPYNRDTYRYTPLLSWLLLPNHMIPWFHFGKLIFVLCDLATGVLILQMLKKLKSKYRYGTDRMTIMAAIWLLNPMVITISTRGNAESVLCFLILSFLYCFLCEQYLLGGLLFGLSIHFKIYPIIYALPIAIYVAAAHYNKTQSVFKSSFKLFLVGFSTLIVLILLTVFMYMLYGDKFIDQTYLYHIYRTDHRHNFSVWNMLLYFNSALPKTSELSKFVFLPQMIIVLAISLTQLRRPSSFPLLCNVLFLETFAFVTFNKVCTSQYFIWYLIFLPFVLYNTRISMRRGIVMLVVWVATQALWLRQGYLLEFEGQNVFYPGLFCASVGFFVSNAWILGQFIEDTIIQNDYVYRIEPSESRSKDSAVIDKPAIAKTEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXR2</accession>
    <name>Q6FXR2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0B03707g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXR2"/>
    <dbReference type="FunCoup" id="Q6FXR2">
        <property type="interactions" value="944"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXR2"/>
    <dbReference type="KEGG" id="cgr:2886563"/>
    <dbReference type="CGD" id="CAL0127132">
        <property type="gene designation" value="CAGL0B03707g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03707g"/>
    <dbReference type="eggNOG" id="KOG2732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021763_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FXR2"/>
    <dbReference type="OMA" id="HCILIGT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006278">
        <property type="term" value="P:RNA-templated DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.430:FF:000002">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.50:FF:000005">
        <property type="entry name" value="DNA polymerase delta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="11">
        <location>
            <begin position="47"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="10">
        <location>
            <begin position="205"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0127132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="479" mass="53763" checksum="698659FA25F10D6D" modified="2004-07-19" version="1">MDSLLEKFNSKRTSTHEKPLQRARINEDFEQDNAFALDFDKRDYSPQYHFLYQYRLTVLKNRIREQCYKKWDAGFQLNGKEVVEKKNVLDIQGKEPCWCIGTIYREMKYKPNVLEEVMNDTYGTVDINPESYTDPDGTDEIMLEDESGRLILVGDMIAETPFITGTVIGVLGMEADAGTFQVLDLCYPKALPQEPMPAATSKGKIALVSGINISTTAQERVIKLQLLQEYLMGRLGNEEAVAQIGRLLICGDSIDFNPSSEDPGALVNKLDEFGKFLGNTLQSISIDIMPGANDPSDRTLPQQPLHKALFRENLGQYFDKVNANLLNLVTNPYVFSINGLELLTTAGQNITDICKYVIPAKSDTESTTNVSTDDTDAKCAKTTEHILDLMECTLKWQNIAPTAPDTLWCYPYKDRDPFILNKWPHVYIVGNQPYFGTRKVSLDGVEVVMISVPTFSETGQIVLLDLEDLSTEVVTIGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY55</accession>
    <name>Q6FY55_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol phosphorylceramide synthase regulatory subunit KEI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0A02794g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY55"/>
    <dbReference type="FunCoup" id="Q6FY55">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY55"/>
    <dbReference type="KEGG" id="cgr:2886367"/>
    <dbReference type="CGD" id="CAL0126851">
        <property type="gene designation" value="CAGL0A02794g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02794g"/>
    <dbReference type="eggNOG" id="ENOG502QT2Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103819_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FY55"/>
    <dbReference type="OMA" id="DQPVGFN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070917">
        <property type="term" value="F:inositol phosphoceramide synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013862">
        <property type="entry name" value="Kei1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28077:SF1">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE REGULATORY SUBUNIT KEI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08552">
        <property type="entry name" value="Kei1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0126851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG57780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="25371" checksum="3B53F9BD261FDCFA" modified="2004-07-19" version="1">MRLNKISFPKSFFGFLPLYLGVEIVLGITILNKCSGAYGILALFTGHPLDYMQWISYLWSVFTLIVFSQGLFMIHKPKLIVFSQILVYFTADTVLTCFFTLWFSAQWFQSANEEKHETSAPVGVSQNYRRSTDLASQGASERYEYTVTMLFTLVTLMFRMYFNFILASFVQELLRHPKYMVDQDDVEQDLKNKSAIKRWWIKSQKFCYKLCRHTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY84</accession>
    <name>Q6FY84_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 12">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0A04235g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 12"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY84"/>
    <dbReference type="FunCoup" id="Q6FY84">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY84"/>
    <dbReference type="KEGG" id="cgr:2886335"/>
    <dbReference type="CGD" id="CAL0126871">
        <property type="gene designation" value="CAGL0A04235g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04235g"/>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014892_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FY84"/>
    <dbReference type="OMA" id="TDYNLSC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990468">
        <property type="term" value="C:NuA3b histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="14">
        <location>
            <begin position="194"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="588"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="619"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0126871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG57844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="719" mass="83067" checksum="EA80F3A37A3A46BB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B4UMY1</accession>
    <name>B4UMY1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0C01435g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAR58005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UMY1"/>
    <dbReference type="FunCoup" id="B4UMY1">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UMY1"/>
    <dbReference type="KEGG" id="cgr:9487970"/>
    <dbReference type="CGD" id="CAL0127638">
        <property type="gene designation" value="CAGL0C01435g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C01435g"/>
    <dbReference type="eggNOG" id="KOG4122">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_1_2_1"/>
    <dbReference type="InParanoid" id="B4UMY1"/>
    <dbReference type="OMA" id="MWAPVAV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_bL36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052143">
        <property type="entry name" value="Mitoribosomal_bL36m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_bL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_bL36_sp"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46909:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL36M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="Ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0127638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAR58005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="82" mass="9608" checksum="98BB82239CE707D3" modified="2008-09-23" version="1">MFPFQLLNRSISSVVRNSVLRPLPMMAATKPLMAPRMLLLFNRGFKVRTSVKKMCSDCYIVRRKGRVYVYCKSNKKHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-31" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>F2Z6H8</accession>
    <name>F2Z6H8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOD-type homing endonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">HO</name>
        <name evidence="2 3" type="ordered locus">CAGL0G05423g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446596.1">
        <property type="nucleotide sequence ID" value="XM_446596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F2Z6H8"/>
    <dbReference type="FunCoup" id="F2Z6H8">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="284593.F2Z6H8"/>
    <dbReference type="GeneID" id="2888324"/>
    <dbReference type="KEGG" id="cgr:2888324"/>
    <dbReference type="CGD" id="CAL0137675">
        <property type="gene designation" value="HO"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05423g"/>
    <dbReference type="eggNOG" id="ENOG502QUGM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033909_0_0_1"/>
    <dbReference type="InParanoid" id="F2Z6H8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007868">
        <property type="entry name" value="Hom_end_hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007869">
        <property type="entry name" value="Homing_endonuc_PI-Sce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006142">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004042">
        <property type="entry name" value="Intein_endonuc_central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05204">
        <property type="entry name" value="Hom_end"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05203">
        <property type="entry name" value="Hom_end_hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00379">
        <property type="entry name" value="INTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55608">
        <property type="entry name" value="Homing endonucleases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50819">
        <property type="entry name" value="INTEIN_ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOD-type homing endonuclease" evidence="1">
        <location>
            <begin position="214"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="578" mass="66443" checksum="7B28F924A0CE2232" modified="2011-05-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIL1</accession>
    <name>Q6FIL1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein transport protein GOT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M13563g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIL1"/>
    <dbReference type="FunCoup" id="Q6FIL1">
        <property type="interactions" value="871"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIL1"/>
    <dbReference type="KEGG" id="cgr:2891224"/>
    <dbReference type="CGD" id="CAL0137453">
        <property type="gene designation" value="CAGL0M13563g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13563g"/>
    <dbReference type="eggNOG" id="KOG1743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124519_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FIL1"/>
    <dbReference type="OMA" id="MWLTDAQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15236" checksum="91B11E05787B422E" modified="2004-07-19" version="1">MWLSESQKFGVAFTFGGVLFFIFGIFTFFDRALLALGNILFLIGVVLIIGSQKTLIFFSRPTKRRGSILFLLGIFLILIKWTFIGFLVESLGIVGLFGDFFGIIVQFLRSLPIIGPILSHPAVAPIVDKIAGVRVLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIQ2</accession>
    <name>Q6FIQ2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-lysine N-methyltransferase EFM4</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Elongation factor methyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">EFM4</name>
        <name evidence="9 10" type="ordered locus">CAGL0M12639g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449892.1">
        <property type="nucleotide sequence ID" value="XM_449892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIQ2"/>
    <dbReference type="FunCoup" id="Q6FIQ2">
        <property type="interactions" value="776"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIQ2"/>
    <dbReference type="GeneID" id="2891443"/>
    <dbReference type="KEGG" id="cgr:2891443"/>
    <dbReference type="CGD" id="CAL0136925">
        <property type="gene designation" value="CAGL0M12639g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M12639g"/>
    <dbReference type="eggNOG" id="KOG1271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044783_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FIQ2"/>
    <dbReference type="OMA" id="PTPSFQF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000287">
        <property type="entry name" value="Protein-lysine N-methyltransferase EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Methyltransferase" evidence="8">
        <location>
            <begin position="64"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="228" mass="25874" checksum="57D6F609F1E151D7" modified="2004-07-19" version="1">MEDTTKLNTSKLGTKEYWDDFYALERQNFEKNPEDTGECWFNDNDAEEKMVEFLMDACGMHNISQECTMIDLGTGNGHLLFALTEEGFHGQMLGVDYSEQSVKFANEIVANKELGEHLRFAQADIFDNNWNPGKFNVVLDKGTLDAIALSGLKFDDDKTIVDVYSKCVERLMEPGSVFLITSCNFTQEELIKIIETDSLKMWECVNYPVFEFGGVKGTTICTVAFVKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIS9</accession>
    <name>KPYK1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pyruvate kinase 1</fullName>
            <shortName>PK 1</shortName>
            <ecNumber>2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PYK1</name>
        <name type="ordered locus">CAGL0M12034g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIS9"/>
    <dbReference type="SMR" id="Q6FIS9"/>
    <dbReference type="FunCoup" id="Q6FIS9">
        <property type="interactions" value="1050"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIS9"/>
    <dbReference type="EnsemblFungi" id="CAGL0M12034g-T">
        <property type="protein sequence ID" value="CAGL0M12034g-T-p1"/>
        <property type="gene ID" value="CAGL0M12034g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891415"/>
    <dbReference type="CGD" id="CAL0137479">
        <property type="gene designation" value="PYK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M12034g"/>
    <dbReference type="eggNOG" id="KOG2323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FIS9"/>
    <dbReference type="OMA" id="RVHHIGE"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000112110" description="Pyruvate kinase 1">
        <location>
            <begin position="1"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P14618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="501" mass="54668" checksum="D3F800A625D7FD4E" modified="2004-07-19" version="1">MDSRLARLTTLQTSAGEELRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYEYHKSVIDNARKSEELYPGRPLAIALDTKGPEIRTGTTTNEVDYPIPPNHEMIFTTDDKYAKACDDKIMYLDYKNITKVISAGRIIYVDDGVLSFEVLQVVDDKTLKVKSLNAGKICSHKGVNLPGTDVDLPALSEKDKADLRFGVENGVHMIFASFIRTAQDVLTIREVLGEDGKDIKIVVKIENQQGVNNFDEILKVTDAVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPTRAEVSDVGNAVLDGADCVMLSGETAKGNYPINAVTTMAETALIAEQAIAYLPNYDDIRNCTPKPTSTTETVAASAVAAVFEQKAKAIIVLSTSGTTARLVSKYRPNCPIILVTRNARTARFSHLYRGVFPFVYEKESVSDWTEDVEARLNFGIEQAIEFGILKKGDTYVSIQGFKAGVGHSNTLQVSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIU4</accession>
    <name>Q6FIU4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">AHP1</name>
        <name evidence="9 10" type="ordered locus">CAGL0M11704g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449850.1">
        <property type="nucleotide sequence ID" value="XM_449850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIU4"/>
    <dbReference type="FunCoup" id="Q6FIU4">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIU4"/>
    <dbReference type="GeneID" id="2891245"/>
    <dbReference type="KEGG" id="cgr:2891245"/>
    <dbReference type="CGD" id="CAL0136519">
        <property type="gene designation" value="AHP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11704g"/>
    <dbReference type="eggNOG" id="KOG0541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072440_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FIU4"/>
    <dbReference type="OMA" id="YTMNGWA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="6">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="175" mass="18946" checksum="88C08E3787CCC9D1" modified="2004-07-19" version="1">MAAPQVNEKFDVKDIKFQYIDFDQSVSHDACAMPSTTSWSDFLAKNKTVVITGAPAAFSPTCSISHIPGYISKLSDLEAKGVDQVVVVTVDNPFANEAWAKNLGVQNTKHIKFATDAGAELVRHLGYELKVGEGVYWSGRWTVIVKDGVVVYAGNESNPASDVTVSSVEEALKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIV8</accession>
    <name>Q6FIV8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0M11396g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIV8"/>
    <dbReference type="FunCoup" id="Q6FIV8">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIV8"/>
    <dbReference type="KEGG" id="cgr:2891405"/>
    <dbReference type="CGD" id="CAL0137405">
        <property type="gene designation" value="CAGL0M11396g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11396g"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002664_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FIV8"/>
    <dbReference type="OMA" id="MPEQAHT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045921">
        <property type="term" value="P:positive regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903896">
        <property type="term" value="P:positive regulation of IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="108"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="14">
        <location>
            <begin position="1143"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="537"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="666"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="804"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1050"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="506"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="834"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0137405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG62816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1192" mass="134431" checksum="5453966BFED45393" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIZ7</accession>
    <name>MAF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MAF1</name>
        <name type="ordered locus">CAGL0M10351g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449797.1">
        <property type="nucleotide sequence ID" value="XM_449797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIZ7"/>
    <dbReference type="FunCoup" id="Q6FIZ7">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIZ7"/>
    <dbReference type="EnsemblFungi" id="CAGL0M10351g-T">
        <property type="protein sequence ID" value="CAGL0M10351g-T-p1"/>
        <property type="gene ID" value="CAGL0M10351g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891361"/>
    <dbReference type="KEGG" id="cgr:2891361"/>
    <dbReference type="CGD" id="CAL0136927">
        <property type="gene designation" value="CAGL0M10351g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M10351g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M10351g"/>
    <dbReference type="eggNOG" id="KOG3104">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037043_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FIZ7"/>
    <dbReference type="OMA" id="INIGPFG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000213971" description="Repressor of RNA polymerase III transcription MAF1">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="391" mass="44346" checksum="FE06EFCC00134295" modified="2004-07-19" version="1">MKFIDELDIERVNQVLNFETIDCKIVGGCDIFTTKAVASDRKLYKTIDHHLDTILQDNESYNLALQQQIALDAEDKNERSMSPGGQRRDSSSFWEQKRRMSVSDSPIYLQHINGNLNESNGAQGEIVADLVPPIIKTSKLNDHNLKELVSNYEAGYSSSSSVESLTHKNKERRTSSLSSTGGKVDKLRADSSTANDITARSVLNDTSRTLNLGPFGPINEPSSRRTFAYLIAILNASYPDHDFSLLEPTDFKRSSIKSFIAKFENSMYSLGRKPEEWIWEVINSHMTLSDCVLYQYCPTQSFLDDEPGHLWSLIGFFFNKKRKRVAYVYLLASRLQLAVNNAIGTPDEMQNEDGTFRNNNTTSFDNNNTQFEGEYDLTYEENAIVDDDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ12</accession>
    <name>Q6FJ12_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M10021g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449782.1">
        <property type="nucleotide sequence ID" value="XM_449782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ12"/>
    <dbReference type="FunCoup" id="Q6FJ12">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891346"/>
    <dbReference type="CGD" id="CAL0137279">
        <property type="gene designation" value="CAGL0M10021g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M10021g"/>
    <dbReference type="eggNOG" id="ENOG502QW4R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038590_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ12"/>
    <dbReference type="OMA" id="RKCVICE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="503" mass="57347" checksum="97E79611CDF16D32" modified="2004-07-19" version="1">MDDQTRLRVFEPLDCNSFVSATPNSTHLSKLSVQTPTTSSFIRNPYERDQTALENQSGSELLRWKYDQREFMFNSNSTPSKNSNSQTEKYEFPITEKLVKNKNPGCKRRTNQLIGAKPSRPSGLQNVTSKLELLDETHFTSLPIPAPKGTKIDNSAILSDIIDDNSDDIITADDSVILPSKRSFRTPANEIKVHNNGNKRYISYKYSNRYPERESSPSEQMISSGKDTHPIVIVEDYLLSDSERSFTESTRKRKRYNSNNDGLKPKLSLHNLKTKIRSSNTDHLPVKKKVHYLKECSTVDSSTNEENEAGSSKCIKEVLNEFLPPKSNSADCDLYISNLLSKGTNELKRCVICEKILYEVSSLLYKENDFKELVCGSCTEKYETIAKLLEGCELESTFEYSLDSSSFEANTLDSSLIQSSHTVCREVTPPHNSSLQHMRRDSFSEDLIKALQSQLIKNSKQIPENSIFPNKALSWFIDARRKLRWRWRVSGLLPEFTINNNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ43</accession>
    <name>Q6FJ43_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase C-like 1</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 26" type="ordered locus">CAGL0M09361g</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 28">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ43"/>
    <dbReference type="FunCoup" id="Q6FJ43">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ43"/>
    <dbReference type="KEGG" id="cgr:2891315"/>
    <dbReference type="CGD" id="CAL0136549">
        <property type="gene designation" value="CAGL0M09361g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09361g"/>
    <dbReference type="eggNOG" id="KOG0694">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_54_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ43"/>
    <dbReference type="OMA" id="QCTHLVP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032186">
        <property type="term" value="P:cellular bud neck septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903139">
        <property type="term" value="P:positive regulation of cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090334">
        <property type="term" value="P:regulation of cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000769">
        <property type="term" value="P:regulation of establishment or maintenance of cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070610">
        <property type="term" value="P:regulation of fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060211">
        <property type="term" value="P:regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037778">
        <property type="entry name" value="C2_fungal_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="24">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="24">
        <location>
            <begin position="112"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="20">
        <location>
            <begin position="201"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
        <location>
            <begin position="422"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="22">
        <location>
            <begin position="489"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="817"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="23">
        <location>
            <begin position="1077"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="556"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="786"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="685"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="592"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="786"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="846"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="CGD" id="CAL0136549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CAG62729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1144" mass="130708" checksum="FC084151D5059D68" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2025-06-18" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJD5</accession>
    <name>NACA_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Nascent polypeptide-associated complex subunit alpha</fullName>
            <shortName>NAC-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">EGD2</name>
        <name type="ordered locus">CAGL0M07161g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Predominantly cytoplasmic, may also transiently localize to the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAC-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449659.1">
        <property type="nucleotide sequence ID" value="XM_449659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJD5"/>
    <dbReference type="SMR" id="Q6FJD5"/>
    <dbReference type="FunCoup" id="Q6FJD5">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJD5"/>
    <dbReference type="EnsemblFungi" id="CAGL0M07161g-T">
        <property type="protein sequence ID" value="CAGL0M07161g-T-p1"/>
        <property type="gene ID" value="CAGL0M07161g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891708"/>
    <dbReference type="KEGG" id="cgr:2891708"/>
    <dbReference type="CGD" id="CAL0137119">
        <property type="gene designation" value="EGD2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M07161g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07161g"/>
    <dbReference type="eggNOG" id="KOG2239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057806_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FJD5"/>
    <dbReference type="OMA" id="SQKMIFA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006613">
        <property type="term" value="P:cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14278">
        <property type="entry name" value="UBA_NAC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000273484" description="Nascent polypeptide-associated complex subunit alpha">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="UBA">
        <location>
            <begin position="126"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="165" mass="17894" checksum="B757BB9D6E0317EF" modified="2004-07-19" version="1">MAEIPEGANVTILNRNEKKARELISKLGLKKVPGIIRVTFRKKDNQIFAIEKPEVFRSVGGNYVVFGEAKVDNFTQRLAAAQQQAQSQTATKTPEDIQADMQAAAVANENKTEGDAAEEDVDAGDLSNDDIDLVVQQTNATKGQAIKALKEHNGDIVNAIMSLSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJI2</accession>
    <name>NPL4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Nuclear protein localization protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NPL4</name>
        <name type="ordered locus">CAGL0M06105g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Localizes mainly at the nuclear periphery and the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NPL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449612.1">
        <property type="nucleotide sequence ID" value="XM_449612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJI2"/>
    <dbReference type="SMR" id="Q6FJI2"/>
    <dbReference type="FunCoup" id="Q6FJI2">
        <property type="interactions" value="1012"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJI2"/>
    <dbReference type="EnsemblFungi" id="CAGL0M06105g-T">
        <property type="protein sequence ID" value="CAGL0M06105g-T-p1"/>
        <property type="gene ID" value="CAGL0M06105g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891660"/>
    <dbReference type="KEGG" id="cgr:2891660"/>
    <dbReference type="CGD" id="CAL0137323">
        <property type="gene designation" value="CAGL0M06105g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06105g"/>
    <dbReference type="eggNOG" id="KOG2834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017172_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJI2"/>
    <dbReference type="OMA" id="KWSRTGR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036266">
        <property type="term" value="C:Cdc48p-Npl4p-Vms1p AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000837">
        <property type="term" value="C:Doa10p ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030894">
        <property type="term" value="C:replisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099638">
        <property type="term" value="P:endosome to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072671">
        <property type="term" value="P:mitochondria-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024682">
        <property type="entry name" value="Npl4_Ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
        <property type="entry name" value="NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11543">
        <property type="entry name" value="UN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000339440" description="Nuclear protein localization protein 4">
        <location>
            <begin position="1"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="MPN" evidence="2">
        <location>
            <begin position="238"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="580" mass="65349" checksum="197DADFBE42E2B88" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJK9</accession>
    <name>Q6FJK9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0M05489g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449585.1">
        <property type="nucleotide sequence ID" value="XM_449585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJK9"/>
    <dbReference type="FunCoup" id="Q6FJK9">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="CAZy" id="GT15">
        <property type="family name" value="Glycosyltransferase Family 15"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891632"/>
    <dbReference type="CGD" id="CAL0137385">
        <property type="gene designation" value="CAGL0M05489g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05489g"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJK9"/>
    <dbReference type="OMA" id="YCDIQYD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF11">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0137385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="426" mass="50194" checksum="E230B8F6A8F77311" modified="2004-07-19" version="1">MGAVKKKLMPKSAMFVRKYEKTIRVGFASFLMALTVLFLMHKPDAGTTAMAPQQTMAGFTSVVKNGQPGYVIPASDLLQDVKEHPLDDGVKEKAAFITLARNGDLWSLVNTIRHVEDRLNHRYHYDWVFLNDKGFTDEFIRLTSALVSGKAKYGKVPKEHWEVPSHIDKEKYEISRRKMVLDKVPYGDSTPYRHMCRYQSGLFYRHELVQEYDYYWRVDTDITVFCNFQYDIFKFLRQNKKKYGFVISLTEYEETIPTLWATVKEFMKKYPQHIHKNNFLNFISDDGGETYNGCHFWTNFEVGDLNFWRSQAYTDFFNFLDQKGGFYYERWGDAPVHSIAAALLLDKDEIHFFDGFGYHHPDFQSCPHEEEVRLQNKCTCNFSKDKIWMTYYFCNLRYFEAKEIGLPPKIEANLDEEYKKKLKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJN9</accession>
    <name>Q6FJN9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M04763g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449555.1">
        <property type="nucleotide sequence ID" value="XM_449555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJN9"/>
    <dbReference type="FunCoup" id="Q6FJN9">
        <property type="interactions" value="1142"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJN9"/>
    <dbReference type="KEGG" id="cgr:2891564"/>
    <dbReference type="CGD" id="CAL0136345">
        <property type="gene designation" value="CAGL0M04763g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04763g"/>
    <dbReference type="eggNOG" id="KOG3274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052828_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FJN9"/>
    <dbReference type="OMA" id="LFITWNK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="234" mass="26892" checksum="25D67708F9689718" modified="2004-07-19" version="1">MVGKNNELYAFYAFLQLYKHMGHVQRDYSLRQVAEALYDTTLIIKEDTSLFITWKRLDSQKTSIDSDDDDGYALRGCIGTFAKLPIEAGIQRYSLIAALEDSRFTPISERELKTLKCSCNILRHFEKIYSSGDDHGDIDNWEIGKNGIELLFKHPKSGKTCSATFLPDVMVEQGWDKKETFLNLIQKAGCWNEAGQILNDYEKYFLEVIKYEGKKSEITYDAFISGFEKLETLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJU0</accession>
    <name>Q6FJU0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M03641g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJU0"/>
    <dbReference type="FunCoup" id="Q6FJU0">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJU0"/>
    <dbReference type="KEGG" id="cgr:2891514"/>
    <dbReference type="CGD" id="CAL0137059">
        <property type="gene designation" value="CAGL0M03641g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03641g"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005350_12_2_1"/>
    <dbReference type="InParanoid" id="Q6FJU0"/>
    <dbReference type="OMA" id="VECDHIS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000133">
        <property type="term" value="C:polarisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070649">
        <property type="term" value="P:formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000057">
        <property type="entry name" value="GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="318"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="721" mass="82599" checksum="1CA33B6DCE88866D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJU1</accession>
    <name>Q6FJU1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M03619g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJU1"/>
    <dbReference type="SMR" id="Q6FJU1"/>
    <dbReference type="FunCoup" id="Q6FJU1">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJU1"/>
    <dbReference type="KEGG" id="cgr:2891513"/>
    <dbReference type="CGD" id="CAL0136707">
        <property type="gene designation" value="CAGL0M03619g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03619g"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FJU1"/>
    <dbReference type="OMA" id="FAINKPC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="7">
        <location>
            <begin position="63"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="404" mass="45510" checksum="F1F09986353FF340" modified="2004-07-19" version="1">MNGIFAIEKPSGISSNQFMMQVQKIFNNSAVFSKEIERATAERRKQFEQQTGKKASKRKLRKVSKVKMGHGGTLDPLASGVLVLGVGTGTKQLSQYLSGTVKVYETEALFGISTTSGDSEGEILSRNSVKHLKLEDVKTVEEKFRGSLKQTPPIYSALKMNGKSLHEYAREGKPLPRAIEPRQVTIYDLEILPKTLSKDHDYKLIETEDESNSQIVKDLNANMLFDTLYYSKEYVEKMNLPSEVAAIEPPIPLTDEEKQEIGELKDKYRAPLLHAKASVSSGTYIRSLVSDIGKAMRTSCYMTKLIRIQQQEWSLEKNNVFKLEDFTDKDEQVWAKVLEIVLEKGSSVNIVEELKNAESLYQQQIKDLKVKETEDLAGATGSTAQPVVEETEHNDLKRKHEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKD2</accession>
    <name>Q6FKD2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0L12518g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449312.1">
        <property type="nucleotide sequence ID" value="XM_449312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKD2"/>
    <dbReference type="KEGG" id="cgr:2890703"/>
    <dbReference type="CGD" id="CAL0135368">
        <property type="gene designation" value="CAGL0L12518g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12518g"/>
    <dbReference type="HOGENOM" id="CLU_2096570_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKD2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0135368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="116" mass="13773" checksum="3910D221CFC22C44" modified="2004-07-19" version="1">MHGFHSKERVMRYRILMETQVLVLYWSIPHKGDAKWLYNHSTTAGLSWMNNSTNMIYVRTRVEAPELDIHNFERTRLHLQLTTRLKDIAMRTFIFPGSRLDSIKMVDNYNGCDFHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKP0</accession>
    <name>Q6FKP0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L09933g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKP0"/>
    <dbReference type="FunCoup" id="Q6FKP0">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKP0"/>
    <dbReference type="KEGG" id="cgr:2891087"/>
    <dbReference type="CGD" id="CAL0135612">
        <property type="gene designation" value="CAGL0L09933g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09933g"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052404_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKP0"/>
    <dbReference type="OMA" id="KKWQPLP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14372">
        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0135612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="408" mass="46896" checksum="B115F197B003829D" modified="2004-07-19" version="1">MGKKSQKAEKAEDKPVLEKETGEDLDSKQQEPIEEPVEVKQDKDEAKEEDLEEVKEDVGDSAKKDITEDTTTKKVENPLLLQLKEAFPNIEEQYVKAVIIASQGALDPAFNALLFLSDPESGKDIELPREPVQQNPSLPPRRKQTQLEQDEMLARQLDKEYNRKRRGERRHHNEREAGRNYERYNNDDLEEDSWSQFVEKDLPEITARAKGSLQETATKVGTWFNGVKKNFIGEGEENDSAYYQDDSHGRDLDEDYGTYVEQQERRQRRGVQDPGYRRGDEQRLNARHRFNSFGASATDDVEGGISLRDEEFGEDEDEEVPPQLPSRARSNDSKKDSEEVKPQEGKKDKVVAETTYIDTPENKEKTKRKWQPLPPEPLNATPTKVNASTKKNKNESEDEFLINSDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKS6</accession>
    <name>Q6FKS6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0L09020g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SNF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKS6"/>
    <dbReference type="FunCoup" id="Q6FKS6">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKS6"/>
    <dbReference type="KEGG" id="cgr:2891099"/>
    <dbReference type="CGD" id="CAL0136178">
        <property type="gene designation" value="CAGL0L09020g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09020g"/>
    <dbReference type="eggNOG" id="KOG3341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070147_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FKS6"/>
    <dbReference type="OMA" id="QIVEVCM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0136178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="233" mass="26992" checksum="4B96E2E9A9A9EDF4" modified="2004-07-19" version="1">MPNFGLSAFDHLNDESYKNVSSNILERQSLELEQQLEVFQGRLIDFAKKHNKDLKANPEFRSRFLRMCSSIGIDPLEIFEKDQHLFNVDDFYYEISVKIIEVCRETKDMNGGVISFDELRNGYFKNLNVTMEDLEKSIDMIQVLDGGFKVFSIRGKKFLRSVPNEITGDQTKILEVCSIMGYASISLLRANFQWDAVRGRSVLEDMAANSMLWIDNQAGNEILYWDPSWIMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKV5</accession>
    <name>Q6FKV5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tropomyosin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L08338g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKV5"/>
    <dbReference type="STRING" id="284593.Q6FKV5"/>
    <dbReference type="KEGG" id="cgr:2890614"/>
    <dbReference type="CGD" id="CAL0135128">
        <property type="gene designation" value="CAGL0L08338g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08338g"/>
    <dbReference type="eggNOG" id="KOG1003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104738_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FKV5"/>
    <dbReference type="OMA" id="AGHYERR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000142">
        <property type="term" value="C:cellular bud neck contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003786">
        <property type="term" value="F:actin lateral binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000282">
        <property type="term" value="P:cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000001">
        <property type="entry name" value="Tropomyosin alpha-1 chain isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000533">
        <property type="entry name" value="Tropomyosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19269">
        <property type="entry name" value="TROPOMYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00261">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0135128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="19355" checksum="52CD118501288A49" modified="2004-07-19" version="1">MDKVKEKLTNLKLEAESWQEKYEELKEQMKQLEQDNIQKENEIKSLTVKNQQLDQEVEKLEDQIKETKELAEESTTLKSHNENFNKKNQMLEEELEETDRKLKETSDRLKEIELNSETLERKTAALQEERDEWEKKYEEVAAKYEDAKKELEEFANSLENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKZ7</accession>
    <name>Q6FKZ7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">DNA polymerase</fullName>
            <ecNumber evidence="21">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 26" type="ordered locus">CAGL0L07348g</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Catalytic component of DNA polymerase delta (DNA polymerase III) which participates in chromosomal DNA replication. Required during synthesis of the lagging DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Participates in leading strand synthesis during replication initiation and termination. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="21"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKZ7"/>
    <dbReference type="FunCoup" id="Q6FKZ7">
        <property type="interactions" value="820"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKZ7"/>
    <dbReference type="KEGG" id="cgr:2890985"/>
    <dbReference type="CGD" id="CAL0135386">
        <property type="gene designation" value="CAGL0L07348g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07348g"/>
    <dbReference type="eggNOG" id="KOG0969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FKZ7"/>
    <dbReference type="OMA" id="CNNCRPR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903459">
        <property type="term" value="P:mitotic DNA replication lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006278">
        <property type="term" value="P:RNA-templated DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.730:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.730:FF:000006">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 21" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 21" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 21" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 21" id="KW-0408">Iron</keyword>
    <keyword evidence="16 21" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="23">
        <location>
            <begin position="247"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="22">
        <location>
            <begin position="545"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="24">
        <location>
            <begin position="1008"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00055225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="CGD" id="CAL0135386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CAG62067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1096" mass="124391" checksum="92DD001D5FBEBA97" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLC7</accession>
    <name>Q6FLC7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0L04422g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLC7"/>
    <dbReference type="FunCoup" id="Q6FLC7">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLC7"/>
    <dbReference type="KEGG" id="cgr:2890637"/>
    <dbReference type="CGD" id="CAL0135192">
        <property type="gene designation" value="CAGL0L04422g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04422g"/>
    <dbReference type="eggNOG" id="KOG2839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_5_3_1"/>
    <dbReference type="InParanoid" id="Q6FLC7"/>
    <dbReference type="OMA" id="ESDESCQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008796">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052846">
        <property type="term" value="F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052847">
        <property type="term" value="F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052845">
        <property type="term" value="F:inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990174">
        <property type="term" value="F:phosphodiesterase decapping endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071545">
        <property type="term" value="P:inositol phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0135192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="176" mass="19986" checksum="9B86297A8602EF37" modified="2004-07-19" version="1">MSLSMEARSGRANQVYGEDGARLVAGCVCLTSDRHHVLMISSSANRNKWILPKGGIETDEPDYKQTAIRETWEEAGCTGEIVSSLGVVKDMRPPKAKTMDRATFERAKSDAEVNKNPPRSEFHFYELIIGKLEDNFPEMHKRDRKLFTYREAKQNLVEAKRPELLEALTRSSIIKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLP9</accession>
    <name>DCW1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mannan endo-1,6-alpha-mannosidase DCW1</fullName>
            <ecNumber>3.2.1.101</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Defective cell wall 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Endo-alpha-1-&gt;6-D-mannanase DCW1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DCW1</name>
        <name type="ordered locus">CAGL0L01727g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for normal synthesis of the cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448845.1">
        <property type="nucleotide sequence ID" value="XM_448845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLP9"/>
    <dbReference type="SMR" id="Q6FLP9"/>
    <dbReference type="FunCoup" id="Q6FLP9">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLP9"/>
    <dbReference type="CAZy" id="GH76">
        <property type="family name" value="Glycoside Hydrolase Family 76"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q6FLP9">
        <property type="glycosylation" value="12 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0L01727g-T">
        <property type="protein sequence ID" value="CAGL0L01727g-T-p1"/>
        <property type="gene ID" value="CAGL0L01727g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890890"/>
    <dbReference type="KEGG" id="cgr:2890890"/>
    <dbReference type="CGD" id="CAL0136136">
        <property type="gene designation" value="DCW1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01727g"/>
    <dbReference type="eggNOG" id="ENOG502QSWP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025694_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FLP9"/>
    <dbReference type="OMA" id="CERNGLC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007117">
        <property type="term" value="P:budding cell bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0134">Cell wall</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0336">GPI-anchor</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000012123" description="Mannan endo-1,6-alpha-mannosidase DCW1">
        <location>
            <begin position="19"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000012124" description="Removed in mature form" evidence="2">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="GPI-anchor amidated serine" evidence="2">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="446" mass="49699" checksum="A0620B99956608ED" modified="2004-07-19" version="1" precursor="true">MRLVTLLSGLVSLVSVFGLELDLDDYASLQNATALVAYGLMDYYTGDQYGKTVGMFSDPYYWWQAGGAWGCMLDYWYFMQNDTYNDKIMAALLHQTGDNNDYVPLNQSTTEGNDDQAFWGIAVMQAAERKFPNPPDDKPQWLYLTQAVFNTMALRWDSETCGGGLRWQIFVWNSGYDYKNTVSNGALFHIAARLARYTGNQSYVDWAERVYDWMEDVHLIDNGTYRYVYDGVSINDNCTTVTKYQWTYNQGLMLSGSAYLFNMTGSDLWHERTHAFLNASRVFFNNSILYEAACQGPNTCNTDQRSFKAYFARFLGSTAELVPETRQQIMTWLNTSALAAAKSCSGGTDGHTCGLNWFRDDWDGMYGLGEQMAALEVMVNTQALKRAPPYNATNGGNSTGDGAAGTKPHPTNLAPLHITGGSRAGAGIITAIIGISIIACALWLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLV3</accession>
    <name>Q6FLV3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0L00407g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FLV3">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLV3"/>
    <dbReference type="KEGG" id="cgr:2891112"/>
    <dbReference type="CGD" id="CAL0134992">
        <property type="gene designation" value="CAGL0L00407g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L00407g"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_22_1_1"/>
    <dbReference type="InParanoid" id="Q6FLV3"/>
    <dbReference type="OMA" id="LCHKNCD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044547">
        <property type="term" value="F:DNA topoisomerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
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        <property type="term" value="P:meiotic chromosome segregation"/>
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        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
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        <property type="term" value="P:mitotic sister chromatid segregation"/>
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    </dbReference>
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        <property type="term" value="P:negative regulation of meiotic joint molecule formation"/>
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    </dbReference>
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        <property type="term" value="P:regulation of reciprocal meiotic recombination"/>
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    </dbReference>
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        <property type="term" value="P:telomere maintenance via recombination"/>
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        <property type="term" value="P:telomeric 3' overhang formation"/>
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    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SF2_C_RecQ"/>
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    </dbReference>
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        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
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        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
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        <property type="entry name" value="RecQ family helicase MusN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HRDC domain"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
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        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
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        <property type="entry name" value="Helicase_Sgs1"/>
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        <property type="entry name" value="HRDC_dom_sf"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="RecQ_Zn-bd"/>
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        <property type="entry name" value="RQC_domain"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
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        <property type="entry name" value="RecQ_Zn_bind"/>
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        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HELICc"/>
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        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="636"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="835"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1146"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="173"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1146"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0134992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG61761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1371" mass="156173" checksum="5570DADACC198979" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLX4</accession>
    <name>Q6FLX4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Iron transport multicopper oxidase FET5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0K12738g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLX4"/>
    <dbReference type="FunCoup" id="Q6FLX4">
        <property type="interactions" value="668"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLX4"/>
    <dbReference type="KEGG" id="cgr:2890425"/>
    <dbReference type="CGD" id="CAL0133809">
        <property type="gene designation" value="CAGL0K12738g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12738g"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_3_1"/>
    <dbReference type="InParanoid" id="Q6FLX4"/>
    <dbReference type="OMA" id="GHNFQIV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061841">
        <property type="term" value="C:high-affinity iron exporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
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        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF434">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274084" description="Iron transport multicopper oxidase FET5" evidence="10">
        <location>
            <begin position="18"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="568"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="26"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="11">
        <location>
            <begin position="156"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="12">
        <location>
            <begin position="364"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0133809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG61733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="70837" checksum="D23C521710619E33" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM73</accession>
    <name>Q6FM73_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-3-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.150</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Type III PIP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0K10384g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + ADP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57923"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
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        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.150" evidence="2"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="Q6FM73"/>
    <dbReference type="FunCoup" id="Q6FM73">
        <property type="interactions" value="898"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM73"/>
    <dbReference type="KEGG" id="cgr:2890091"/>
    <dbReference type="CGD" id="CAL0134255">
        <property type="gene designation" value="CAGL0K10384g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10384g"/>
    <dbReference type="eggNOG" id="KOG0230">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000480_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FM73"/>
    <dbReference type="OMA" id="QSVWNDT"/>
    <dbReference type="PHI-base" id="PHI:9274"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000285">
        <property type="term" value="F:1-phosphatidylinositol-3-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03334">
        <property type="entry name" value="Fab1_TCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17300">
        <property type="entry name" value="PIPKc_PIKfyve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.810.10:FF:000001">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 3-phosphate 5-kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000283">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000005">
        <property type="entry name" value="1-phosphatidylinositol-3-phosphate 5-kinase (Fab1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
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    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044769">
        <property type="entry name" value="PIKfyve_PIPKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45748:SF7">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 3-PHOSPHATE 5-KINASE-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01504">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="281"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="16">
        <location>
            <begin position="1757"/>
            <end position="2092"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="458"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1576"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1751"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1021"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1338"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1774"/>
            <end position="1785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012009"/>
        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0134255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG61634.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="2104" mass="241859" checksum="113BDF6EF154E489" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM80</accession>
    <name>Q6FM80_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase-associated protein LEO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K10230g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM99</accession>
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        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
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        <name evidence="2 3" type="ordered locus">CAGL0K09812g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
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            <dbReference type="Proteomes" id="UP000002428"/>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="37531" checksum="FEB62BF30421AE58" modified="2004-07-19" version="1">MAVRVRVRGRKSKGKGHGHGGERITVKQEAGEDIDQLVQVQKPRAKLRVQEAATQKRREKPAARVTPAREVPLADRIEVKHKSVKTSRTGSNDRQRNRANGVDPFERMIRHQLGVIGYTEITNPQMKRFLSLSTPNKINAMRGLGFTDERIMSLFNSTGVKVTELSMKKADQMQKQKQNQKDSSDTGFGKRKEKSTNGVRNNTQSIEGTPSTIVDTPRNGLEIPLMSPGLAITNRNKLVISTSTKPDNGNLLTIYNLTLGLDQEKLKDILESYGNTEIDKVVVRDLPTGSAMATVHLKEPSTEELIRVRDFFHGATVDGRTIQVMISADPTKNLSSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMC4</accession>
    <name>Q6FMC4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YTP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0K09218g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMC4"/>
    <dbReference type="FunCoup" id="Q6FMC4">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMC4"/>
    <dbReference type="KEGG" id="cgr:2890252"/>
    <dbReference type="CGD" id="CAL0134613">
        <property type="gene designation" value="CAGL0K09218g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09218g"/>
    <dbReference type="eggNOG" id="ENOG502QW3E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012543_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FMC4"/>
    <dbReference type="OMA" id="NKGWAWN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012768285" description="Protein YTP1" evidence="3">
        <location>
            <begin position="16"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="560"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="4">
        <location>
            <begin position="68"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="5">
        <location>
            <begin position="293"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0134613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="66475" checksum="A5210EE8545E6EDC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMG9</accession>
    <name>Q6FMG9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0K08140g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMG9"/>
    <dbReference type="FunCoup" id="Q6FMG9">
        <property type="interactions" value="1105"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMG9"/>
    <dbReference type="KEGG" id="cgr:2890343"/>
    <dbReference type="CGD" id="CAL0134633">
        <property type="gene designation" value="CAGL0K08140g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08140g"/>
    <dbReference type="eggNOG" id="KOG3330">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087110_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMG9"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033106">
        <property type="term" value="C:cis-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="197" mass="22529" checksum="C68233C7BCD00DCB" modified="2004-07-19" version="1">MSRSQSISSQSKSLKITGEEIWKNKVEKVNSELFNLTYGSIVSQLCIDYKRDFKKVNEQLFSMGYNIGIRLIEDFLARTALPRCDTMLRTSEVISKCAFKVFLNITPTVTNWSQSQDTFSLLIDENPLSDFVELPMDAVNQLWYSNILCGVLKGALEMVQLDCDVWFISDILRGDPQTELRIKLNKVLKDEIPIGED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-05-10" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMQ0</accession>
    <name>PPN1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Endopolyphosphatase</fullName>
            <ecNumber>3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PPN1</name>
        <name type="ordered locus">CAGL0K06237g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Processing by proteases in the vacuole may be required for activation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448494.1">
        <property type="nucleotide sequence ID" value="XM_448494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMQ0"/>
    <dbReference type="SMR" id="Q6FMQ0"/>
    <dbReference type="FunCoup" id="Q6FMQ0">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMQ0"/>
    <dbReference type="GlyCosmos" id="Q6FMQ0">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0K06237g-T">
        <property type="protein sequence ID" value="CAGL0K06237g-T-p1"/>
        <property type="gene ID" value="CAGL0K06237g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890459"/>
    <dbReference type="KEGG" id="cgr:2890459"/>
    <dbReference type="CGD" id="CAL0134089">
        <property type="gene designation" value="CAGL0K06237g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06237g"/>
    <dbReference type="eggNOG" id="KOG3770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013424_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FMQ0"/>
    <dbReference type="OMA" id="WAERYSV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000058544" description="Endopolyphosphatase">
        <location>
            <begin position="1"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="topological domain" description="Vacuolar" evidence="2">
        <location>
            <begin position="36"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="534"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q04119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="663" mass="76352" checksum="DC75EC4189E9646C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-01-10" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMT2</accession>
    <name>SGO1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Shugoshin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SGO1</name>
        <name type="ordered locus">CAGL0K05445g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the shugoshin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448462.1">
        <property type="nucleotide sequence ID" value="XM_448462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMT2"/>
    <dbReference type="SMR" id="Q6FMT2"/>
    <dbReference type="FunCoup" id="Q6FMT2">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMT2"/>
    <dbReference type="EnsemblFungi" id="CAGL0K05445g-T">
        <property type="protein sequence ID" value="CAGL0K05445g-T-p1"/>
        <property type="gene ID" value="CAGL0K05445g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890486"/>
    <dbReference type="KEGG" id="cgr:2890486"/>
    <dbReference type="CGD" id="CAL0134399">
        <property type="gene designation" value="CAGL0K05445g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05445g"/>
    <dbReference type="eggNOG" id="ENOG502QSMK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019322_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMT2"/>
    <dbReference type="OMA" id="HQPKTYR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070199">
        <property type="term" value="P:establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051383">
        <property type="term" value="P:kinetochore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034090">
        <property type="term" value="P:maintenance of meiotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051757">
        <property type="term" value="P:meiotic sister chromatid separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034096">
        <property type="term" value="P:positive regulation of maintenance of meiotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011516">
        <property type="entry name" value="Shugoshin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07558">
        <property type="entry name" value="Shugoshin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000055446" description="Shugoshin">
        <location>
            <begin position="1"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="331"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="483"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="603" mass="68724" checksum="DD5BC8C6A9417AAB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN34</accession>
    <name>Q6FN34_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0K03113g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN34"/>
    <dbReference type="FunCoup" id="Q6FN34">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN34"/>
    <dbReference type="KEGG" id="cgr:2890222"/>
    <dbReference type="CGD" id="CAL0134541">
        <property type="gene designation" value="CAGL0K03113g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03113g"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FN34"/>
    <dbReference type="OMA" id="ARQWTIR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000029">
        <property type="entry name" value="Obg-like ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF9">
        <property type="entry name" value="OBG-LIKE ATPASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="6">
        <location>
            <begin position="26"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="427" mass="48332" checksum="DECDD36F0582FC38" modified="2004-07-19" version="1">MKPTTNKKAKMKLPNILDALKVTNNPTSGIVGLANVGKSTFFQTITNSHLGTAANYPYATIDPEVAKVPIPSPELPVLQKLYQSGKVIPAALTIYDIAGLTRGASEGHGLGNKFLSDIRHVDGIFNLVRGFKDENITHIEGNVDPVRDLSVVQDELILKDLEFIDNVREKASRKLRMLSKNSKEYQEYNFEIELLGKLEEHLYDGKRISNFKNEDEKWNVDEIKVLRRNNFLTAKPSLTLLNVSPEEYLQLHSQNTLENAAFSKEVTEWLKEYSPNDDLIYFSAEYEKNYLEYTKNNDKSGLAQYCKNVAGTDINTSDKRTALPDIILRMKHLLGLISFYTCGPLEVRQWNIRRGNNAQEAAGVIHTDLQETFISADIINYESLRDIEPPLDESYLKKKGLIKRVGKQYIMEENDIALFKAAGGKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNL2</accession>
    <name>Q6FNL2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="14">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ERG7</name>
        <name evidence="17 18" type="ordered locus">CAGL0J10824g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-2,3-epoxysqualene = lanosterol</text>
            <dbReference type="Rhea" id="RHEA:14621"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="EC" id="5.4.99.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:14622"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="13">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="14"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448182.1">
        <property type="nucleotide sequence ID" value="XM_448182.1"/>
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        <property type="gene designation" value="ERG7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10824g"/>
    <dbReference type="eggNOG" id="KOG0497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009074_2_1_1"/>
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    <dbReference type="OMA" id="CWARQTI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:lanosterol synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:ergosterol biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:triterpenoid biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="16">
        <location>
            <begin position="86"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="15">
        <location>
            <begin position="388"/>
            <end position="720"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0133068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG61133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="733" mass="83810" checksum="880BB8EB258E8AB2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNS0</accession>
    <name>Q6FNS0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0J09548g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAG61075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="cgr:2889937"/>
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        <property type="gene designation" value="CAGL0J09548g"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09548g"/>
    <dbReference type="eggNOG" id="KOG2744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002419_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNS0"/>
    <dbReference type="OMA" id="NPIVCGR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031496">
        <property type="term" value="P:positive regulation of mating type switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="ARID_Swi1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964:SF27">
        <property type="entry name" value="HAT-TRICK, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="6">
        <location>
            <begin position="491"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="206"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="615"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="256"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="615"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="692"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="718"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0133226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1417" mass="158626" checksum="78092941AD72187E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="163" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNS8</accession>
    <name>Q6FNS8_CANGA</name>
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        <recommendedName>
            <fullName evidence="11">Cell division control protein 48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CDC48</name>
        <name evidence="8 9" type="ordered locus">CAGL0J09350g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448116.1">
        <property type="nucleotide sequence ID" value="XM_448116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNS8"/>
    <dbReference type="FunCoup" id="Q6FNS8">
        <property type="interactions" value="1572"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNS8"/>
    <dbReference type="GeneID" id="2889928"/>
    <dbReference type="KEGG" id="cgr:2889928"/>
    <dbReference type="CGD" id="CAL0129459">
        <property type="gene designation" value="CDC48"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09350g"/>
    <dbReference type="eggNOG" id="KOG0730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_0_1"/>
    <dbReference type="InParanoid" id="Q6FNS8"/>
    <dbReference type="OMA" id="VWPAYPE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071630">
        <property type="term" value="P:nuclear protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000004">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="7">
        <location>
            <begin position="35"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="6">
        <location>
            <begin position="135"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="247"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="520"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="792"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="830" mass="91061" checksum="EB6CC1B5330A2A4F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNT3</accession>
    <name>Q6FNT3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">homocitrate synthase</fullName>
            <ecNumber evidence="6">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LYS21</name>
        <name evidence="17 18" type="ordered locus">CAGL0J09240g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="6"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448111.1">
        <property type="nucleotide sequence ID" value="XM_448111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNT3"/>
    <dbReference type="FunCoup" id="Q6FNT3">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNT3"/>
    <dbReference type="GeneID" id="2889949"/>
    <dbReference type="KEGG" id="cgr:2889949"/>
    <dbReference type="CGD" id="CAL0133504">
        <property type="gene designation" value="LYS21"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09240g"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FNT3"/>
    <dbReference type="OMA" id="NMFAHES"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="16">
        <location>
            <begin position="34"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="409"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0133504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG61062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="437" mass="48415" checksum="C72C5ED01CD22833" modified="2004-07-19" version="1">MDQYQQVTESTPTVETSNPYGPNPADFLSNVKEFQLIDSTLREGEQFANAFFDTEKKIEIAKALDDFGVDYIELTSPVASEQSFRDCKAICNLGLKAKILTHIRCHMDDAKVAVETGVDGVDVVIGTSKFLRQYSHGKDMNYIAKSAIEVIEFVKSKGIEIRFSSEDSFRSDLVDLLNIYKTVDKIGVNRVGIADTVGCANPRQVYELVRTLKSVVSCDIECHFHNDTGCAIANAYTALEGGAKLIDVSVLGIGERNGITPLGGLMARMIVAAPEYVKSKYKLHKIRDIENLVAEAVEVNIPFNNPITGFCAFTHKAGIHAKAILANPSTYEILDPHDFGMKRYIHFANRLTGWNAIKSRVDQLNLNLTDDQVKEVTTKIKKLGDIRPLNIDDVDSIIKDFHADLATPMVRPTEDGADNEEPLQLDEPAKKKSKLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNT4</accession>
    <name>Q6FNT4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CDC53</name>
        <name evidence="7 8" type="ordered locus">CAGL0J09218g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448110.1">
        <property type="nucleotide sequence ID" value="XM_448110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNT4"/>
    <dbReference type="FunCoup" id="Q6FNT4">
        <property type="interactions" value="1179"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNT4"/>
    <dbReference type="GeneID" id="2889948"/>
    <dbReference type="KEGG" id="cgr:2889948"/>
    <dbReference type="CGD" id="CAL0133046">
        <property type="gene designation" value="CDC53"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09218g"/>
    <dbReference type="eggNOG" id="KOG2166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004747_6_1_1"/>
    <dbReference type="InParanoid" id="Q6FNT4"/>
    <dbReference type="OMA" id="IREWDRY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043224">
        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000038">
        <property type="entry name" value="CDC53p Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000014">
        <property type="entry name" value="CDC53p Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000675">
        <property type="entry name" value="Cell division cycle-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="6">
        <location>
            <begin position="439"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0133046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="822" mass="94721" checksum="99CA0FC9E11BAAC8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNU9</accession>
    <name>TBG_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Tubulin gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Gamma-tubulin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TUB4</name>
        <name type="ordered locus">CAGL0J08888g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448095.1">
        <property type="nucleotide sequence ID" value="XM_448095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNU9"/>
    <dbReference type="SMR" id="Q6FNU9"/>
    <dbReference type="FunCoup" id="Q6FNU9">
        <property type="interactions" value="746"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNU9"/>
    <dbReference type="EnsemblFungi" id="CAGL0J08888g-T">
        <property type="protein sequence ID" value="CAGL0J08888g-T-p1"/>
        <property type="gene ID" value="CAGL0J08888g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889469"/>
    <dbReference type="KEGG" id="cgr:2889469"/>
    <dbReference type="CGD" id="CAL0133032">
        <property type="gene designation" value="CAGL0J08888g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J08888g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08888g"/>
    <dbReference type="eggNOG" id="KOG1374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015718_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FNU9"/>
    <dbReference type="OMA" id="HRYISIL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008275">
        <property type="term" value="C:gamma-tubulin small complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005822">
        <property type="term" value="C:inner plaque of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005824">
        <property type="term" value="C:outer plaque of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051417">
        <property type="term" value="P:microtubule nucleation by spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000767">
        <property type="term" value="P:positive regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000048450" description="Tubulin gamma chain">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="144"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="465" mass="52344" checksum="730825BE406D0F75" modified="2004-07-19" version="1">MTGEIITIQVGQCGNHVGKYFWNQLLKEHGIDKDGYSKYNDDLTHIREDDTNPFFKQITNNRYVPRAIMIDLEPAAVTDVQSSFNDLFNPRNTWVSSEGLGAGNSWSTGYDRGVQNQDRIMDIIDRELDSTDNFEGFQLLHSVAGGTGSGLGSSLLEALTDRYSKSFITTYSVFPSKQSEVVVGPYNTVLTLRRLCEDADASIIFDNNALLNLTARTFRDPNTSYEHTNQLISSALSSITNSLRFPSYMYNSMASIFSTLIPTPELHFLTPNFTPFTPDYIIGGQRYKKNTAYDVLLDLLDPFNSLVTQRSDMVTHFNVFSTVIGEVDQNHILRALPKMQQRLNMPSWSTSALNVNIGRRSPYLPPLESRENSVSGLMLSNTSAITSVFERSASAFDKLFYKGAFLNQFESGQLFQNGLDEFVESREVITRMMEEYSNAEQDTYLDDILNEDDIMIGGFDNEGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNZ1</accession>
    <name>Q6FNZ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein SIP3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0J07942g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNZ1"/>
    <dbReference type="FunCoup" id="Q6FNZ1">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNZ1"/>
    <dbReference type="KEGG" id="cgr:2889860"/>
    <dbReference type="CGD" id="CAL0132962">
        <property type="gene designation" value="CAGL0J07942g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07942g"/>
    <dbReference type="eggNOG" id="ENOG502QU87">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001720_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNZ1"/>
    <dbReference type="OMA" id="TKVEWLW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1046"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1078"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="308"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="9">
        <location>
            <begin position="770"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0132962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1244" mass="145162" checksum="2D1670F9CFF03856" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPJ6</accession>
    <name>Q6FPJ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminopeptidase P N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0J03300g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPJ6"/>
    <dbReference type="FunCoup" id="Q6FPJ6">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPJ6"/>
    <dbReference type="KEGG" id="cgr:2889735"/>
    <dbReference type="CGD" id="CAL0133260">
        <property type="gene designation" value="CAGL0J03300g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03300g"/>
    <dbReference type="eggNOG" id="KOG2414">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FPJ6"/>
    <dbReference type="OMA" id="DSYFWYL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="7">
        <location>
            <begin position="46"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0133260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="487" mass="55246" checksum="37B29456753C54A0" modified="2004-07-19" version="1">MTMMLRRYLSNGAKFVNRPKVQWNLGQRLHENRPFLLQPGELTPGITAAEYYQRRAELVRNLPVGSCLIILANQIKFASGAVFYPFQQDNDLFYLTGWNEPDSIMVLEKPSENIEDHELTMFVPPKNEFKEKWEGFRTGVDAVKEFFNADHSYSVDNSMSMVNELAKIIKRNKGIYFDPDSNKNSKINSNILNLIKETNKGTPKKLKSLVADLRKVKSESEIRLMRRAGQISGRSYNMAMAQRFRNERTLHTFLEHKFISGGCDKSAYIPVVATGPNALCIHYTSNDDVMYDDEMVLVDAAGALGGYCSDISRTWPVAGKWPSSAHKDLYEAVLNVQRESLKNCKKALENNMSLHDLHEASVKLTKQELKNLNFSKATEIAEKLYPHYIGHNLGLDVHDVPEVSRFNPLVEGQVITIEPGLYIPDSPEYPAEFRNIGIRIEDDVVLKKDGYINLTVEAVKEIKDIENVMQNGTTTDFEDDVVSPLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPW2</accession>
    <name>Q6FPW2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome-interacting protein CIC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J00473g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPW2"/>
    <dbReference type="FunCoup" id="Q6FPW2">
        <property type="interactions" value="658"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPW2"/>
    <dbReference type="KEGG" id="cgr:2889876"/>
    <dbReference type="CGD" id="CAL0133592">
        <property type="gene designation" value="CAGL0J00473g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J00473g"/>
    <dbReference type="eggNOG" id="KOG1685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049748_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPW2"/>
    <dbReference type="OMA" id="SFYKPWK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="365" mass="41087" checksum="20EB225834DC8CB2" modified="2004-07-19" version="1">MAKKGVKKQVKNKEEGLSRERIGRALGSLKKYLEAQEGGEKTQLLEDESLGDLQLLFTNAESFTGSKKSFKLKLVDVKHSLYAKWKAASATEIKDFKVLLILKDSDVSKVTQDELYDQLNESGIEIDEIICGKDLKTTYKAYEARNAFISQFSLVIADDSVVTALPKLLGGKAYSKVETTPIPIRCNLKGQFSLNALTNQIKKIYLHKLPVRAPRGNMLNVHLGRVNWFTDEEIIDNIESVADALIKDAKIRNIMLKTTTSPSLPIYRNDNVIDEMVKENTVDDEKAEDVKTVKIGEVDVELSNFDRALMEVANPEEYETMFSKQISKAKRAREEEPEVEEKTPVKKGKNDSKQVKGKKSPKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ67</accession>
    <name>Q6FQ67_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="11">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="11">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="11">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="primary">PSD2</name>
        <name evidence="14 15" type="ordered locus">CAGL0I08745g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="11">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endosome membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The C2 domains have an essential, but non-catalytic function. They may facilitate interaction with PstB2 and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="11"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447627.1">
        <property type="nucleotide sequence ID" value="XM_447627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ67"/>
    <dbReference type="FunCoup" id="Q6FQ67">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ67"/>
    <dbReference type="GeneID" id="2888997"/>
    <dbReference type="KEGG" id="cgr:2888997"/>
    <dbReference type="CGD" id="CAL0132488">
        <property type="gene designation" value="CAGL0I08745g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08745g"/>
    <dbReference type="eggNOG" id="KOG2419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002661_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ67"/>
    <dbReference type="OMA" id="KTSWRKH"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10 11" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023539825" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="11">
        <location>
            <begin position="1"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023539826" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="11">
        <location>
            <begin position="1135"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="572"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="193"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="396"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="493"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="991"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="1048"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="11">
        <location>
            <position position="1135"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="11">
        <location>
            <position position="1135"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="11">
        <location>
            <begin position="1134"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="11">
        <location>
            <position position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0132488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1233" mass="140739" checksum="88EA967FCD6BD41B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQA7</accession>
    <name>Q6FQA7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0I07777g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQA7"/>
    <dbReference type="FunCoup" id="Q6FQA7">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQA7"/>
    <dbReference type="KEGG" id="cgr:2889007"/>
    <dbReference type="CGD" id="CAL0132084">
        <property type="gene designation" value="CAGL0I07777g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07777g"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087689_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQA7"/>
    <dbReference type="OMA" id="KYYTSWC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5013017284" description="Thioredoxin domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="5"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0132084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="240" mass="27508" checksum="D6D6314F376F045F" modified="2004-07-19" version="1">MRFSLILAVLAVAFAEIIPIESIDQFYDLANKDGTYTVVKYYTEWCSHCKKLKSVYKELDEQLSSESNLNAPIQFVEVDCDTYGSTICKRLPGYPIVEVVKPPTLDANTTVTDTPTLFERVKRAIFGENTWTISDDRIVRFEGSRSVNPLQGFITMVVNKDVMKRQLMDIIEGRPIEAQDKVLNAIKEYYNELEHNNLVHERARLERILKTNDDGQLDIVKGQLELINLLETTNEIVDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQC3</accession>
    <name>Q6FQC3_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0I07425g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQC3"/>
    <dbReference type="FunCoup" id="Q6FQC3">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889220"/>
    <dbReference type="CGD" id="CAL0132686">
        <property type="gene designation" value="CAGL0I07425g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07425g"/>
    <dbReference type="HOGENOM" id="CLU_861098_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQC3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="279" mass="31811" checksum="9CBBE4E73BC0B61B" modified="2004-07-19" version="1">MSQLAKLDNVAVVRHVLNYAVLRIDVGSTMGWGLYRDCWAGETSGYVSYFLRDDDEDVTLVGATDLAGGYDFNVVPLVLCGVKGVDEKIEKFVQFFTAVAAKYKAMYSAVYGNWLKLLESYCYFSSSLVWHNWSKWCQSNGSSKLDKDTSTYLYDKLIANYLILGESNQYSIDQFTTVLKNRMLRIYNSTRKRTFGKKKIENYNPYLNYGIWFDLSNGIVLFINCELAATIELNEMKLHSSFGACIDELPIDDLVRKLLVFCNMSLVECLMRETSGPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQE1</accession>
    <name>Q6FQE1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe repressor of activation 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I06985g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQE1"/>
    <dbReference type="FunCoup" id="Q6FQE1">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQE1"/>
    <dbReference type="KEGG" id="cgr:2889061"/>
    <dbReference type="CGD" id="CAL0129895">
        <property type="gene designation" value="CAGL0I06985g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06985g"/>
    <dbReference type="eggNOG" id="KOG3348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FQE1"/>
    <dbReference type="OMA" id="VHAFSQK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071281">
        <property type="term" value="P:cellular response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9547" checksum="121C275DE413EB29" modified="2004-07-19" version="1">MITEEHLREKLKTSIPDVYHVIVTDLSYGCGQSFDVVVVSNTFVGKNKIQRSRLVNGALKEELADIHAFSCKCYSEEEWSKIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQL4</accession>
    <name>Q6FQL4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc transporter YKE4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0I05280g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQL4"/>
    <dbReference type="FunCoup" id="Q6FQL4">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQL4"/>
    <dbReference type="KEGG" id="cgr:2889200"/>
    <dbReference type="CGD" id="CAL0132750">
        <property type="gene designation" value="CAGL0I05280g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05280g"/>
    <dbReference type="eggNOG" id="KOG2693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQL4"/>
    <dbReference type="OMA" id="HEVPHHI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF16">
        <property type="entry name" value="ZINC TRANSPORTER ZIP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274788" description="Zinc transporter YKE4" evidence="7">
        <location>
            <begin position="19"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0132750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="38020" checksum="12A807F684580E7E" modified="2004-07-19" version="1">MIAIGILVLSLCSQFCIGHSIEGKHDHGSGSGHSHSHTHPGDDNSYIQQFTFDVLEKYVFQYSPKVNALLASTIIQATPCLLVLLVPGLRNITNMNDESILITALEAFAFGTLMGDIFCHLIPESFQLFPAHEVGSSLFYGFLGFLVLDKLMKMLNEDDSELGHSHGHSHSHSHTQKSDNDESTNEKESKPHSAKNTNATKYIHVISGLLHHSVDGLVLASSFYVSTATGAITTVAILFHEVPHELGDFSIMLSSGFTYWGAFKAQMTIGMSAIVGTLFSCYLNETGQSTFNFETDRLLPITAGGFIFMATTGLLPRILAHKPTSNYSTFSIQLLCILVGFYTMSAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQN5</accession>
    <name>Q6FQN5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Chitin synthase</fullName>
            <ecNumber evidence="2 7">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0I04818g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 7"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQN5"/>
    <dbReference type="SMR" id="Q6FQN5"/>
    <dbReference type="FunCoup" id="Q6FQN5">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQN5"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889366"/>
    <dbReference type="CGD" id="CAL0132482">
        <property type="gene designation" value="CAGL0I04818g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04818g"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004760_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FQN5"/>
    <dbReference type="OMA" id="TTMRETE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="592"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="656"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="855"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="9">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0132482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="914" mass="105013" checksum="32FA4E3AB88926CF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQP5</accession>
    <name>Q6FQP5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial chaperone TCM62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I04598g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQP5"/>
    <dbReference type="FunCoup" id="Q6FQP5">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQP5"/>
    <dbReference type="KEGG" id="cgr:2889036"/>
    <dbReference type="CGD" id="CAL0132178">
        <property type="gene designation" value="CAGL0I04598g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04598g"/>
    <dbReference type="eggNOG" id="KOG0356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485763_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQP5"/>
    <dbReference type="OMA" id="PSKMCAD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="64114" checksum="3078803D5B7305AA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2025-04-09" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQU6</accession>
    <name>SC132_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein transport protein SEC13-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SEC132</name>
        <name type="ordered locus">CAGL0I03454g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447398.1">
        <property type="nucleotide sequence ID" value="XM_447398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQU6"/>
    <dbReference type="SMR" id="Q6FQU6"/>
    <dbReference type="STRING" id="284593.Q6FQU6"/>
    <dbReference type="EnsemblFungi" id="CAGL0I03454g-T">
        <property type="protein sequence ID" value="CAGL0I03454g-T-p1"/>
        <property type="gene ID" value="CAGL0I03454g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889177"/>
    <dbReference type="CGD" id="CAL0130139">
        <property type="gene designation" value="CAGL0I03454g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I03454g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03454g"/>
    <dbReference type="eggNOG" id="KOG1332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FQU6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0906">Nuclear pore complex</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000295410" description="Protein transport protein SEC13-2">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="7"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="149"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="209"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="261"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q04491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="303" mass="33237" checksum="66852BE8B0DA1A45" modified="2004-07-19" version="1">MVKIENAHEGVIHHAALNYYGTRLATCSSDKTVKIFEINDVNNSSSLLETLVGHEGPVWYADWCHPSLGENLLATCGYDGKVLIWKESGHGGKMQIIGKHAVHSASVNCVKWAPHEYGLILLCGSADGKISVVELKDGQIASTKILDNAHKFGVNSISWAPLMKTDSSDDGDETTAVKQFISGGNDNLVKIWKFDDDQETYVVADTLEGHKDAVTAVDWSPTTLLQSYVASVSNDKQCLVWTQDHSSKKNDWKKISVNEGKFEQKLGSVSWSLSGNLLAVSDDDKNVTIWKESGDGKWEEVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR22</accession>
    <name>Q6FR22_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0I01584g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR22"/>
    <dbReference type="FunCoup" id="Q6FR22">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR22"/>
    <dbReference type="DNASU" id="2889321"/>
    <dbReference type="KEGG" id="cgr:2889321"/>
    <dbReference type="CGD" id="CAL0130059">
        <property type="gene designation" value="CAGL0I01584g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01584g"/>
    <dbReference type="eggNOG" id="KOG2271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019986_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR22"/>
    <dbReference type="OMA" id="VKHYSWM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0130059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="722" mass="82511" checksum="79A2F9D4BE561FF0" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR63</accession>
    <name>Q6FR63_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I00638g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR63"/>
    <dbReference type="FunCoup" id="Q6FR63">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR63"/>
    <dbReference type="KEGG" id="cgr:2889299"/>
    <dbReference type="CGD" id="CAL0132260">
        <property type="gene designation" value="CAGL0I00638g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00638g"/>
    <dbReference type="eggNOG" id="KOG4288">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055314_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FR63"/>
    <dbReference type="OMA" id="WERADIF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="260" mass="29295" checksum="EAB620FBDC5DFFBC" modified="2004-07-19" version="1">MQSLLVFGGNGFLGKRICQEAIRQGLKVTSISRSGQPPSSSNAGDLKWIEKVNWKSADIFEPESYASSLREADHVVHSMGILLENENYKKLLNGGSFELKFGANPLEKTDSGNFTYERMNKESVLILAKAFDTVKKANPRTSLSYISADNWNPIITDGYINSKREAERELLKFKSFRTIVARPGFMYDENRNASDKRHLVQSTLDFFNWTNKTLLGNSIRCVNNMIRPTISAQQVSRALVAKINDPSFSGILYLEDLLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRC9</accession>
    <name>Q6FRC9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cold shock-induced protein TIR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIR5</name>
        <name evidence="5 6" type="ordered locus">CAGL0H09592g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447215.1">
        <property type="nucleotide sequence ID" value="XM_447215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRC9"/>
    <dbReference type="FunCoup" id="Q6FRC9">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRC9"/>
    <dbReference type="KEGG" id="cgr:2888530"/>
    <dbReference type="CGD" id="CAL0131672">
        <property type="gene designation" value="TIR5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09592g"/>
    <dbReference type="eggNOG" id="ENOG502RYU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071083_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRC9"/>
    <dbReference type="OMA" id="MAYTKIA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000992">
        <property type="entry name" value="SRP1_TIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000420">
        <property type="entry name" value="Yeast_PIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00399">
        <property type="entry name" value="PIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00660">
        <property type="entry name" value="SRP1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50256">
        <property type="entry name" value="PIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273491" description="Cold shock-induced protein TIR1" evidence="4">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="22899" checksum="84CE286F575C85B7" modified="2004-07-19" version="1">MAYSKTAILIAAAAALVSAQTPQQLDELNVILDDVKSNLSSYMSLVQDPSSGITLANLPAGVLNLGMALASATDDSYTTLYKDIDFDGIVPFLSKLPWYSERLAGKLAKDLGEASSSAAPSSSAAPSSSAAPTTSSSAAPTTSSSAAPSSSKASSSAAPSSSKASSSAAPSSSKAASSSAKASSSAKASTTVVTSATKAAISQIGDGQIQAQTANGAGKVAAGMGAGVIAAAALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRJ5</accession>
    <name>Q6FRJ5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0H08063g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRJ5"/>
    <dbReference type="FunCoup" id="Q6FRJ5">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRJ5"/>
    <dbReference type="KEGG" id="cgr:2888438"/>
    <dbReference type="CGD" id="CAL0131610">
        <property type="gene designation" value="CAGL0H08063g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08063g"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FRJ5"/>
    <dbReference type="OMA" id="QLRDWSD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0131610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="290" mass="31222" checksum="83DF9D49904CFC5B" modified="2004-07-19" version="1">MVNTLDKTFLEKSSWKPDLFKGKVGFVTGGAGTICRVQVEALVLLGCKVAIIGRDHEKTERVAKEISSLVDNPDAVLPISKVDVREVKQLESAVKRTVDRYGRIDYVIAGAAGNFICDFNHLSANAFKSVVSIDLLGSFNTAKATMPELIKSRGSILFVSATFHYYGVPFQSHVGAAKAGIDALSNALAVEMGPFGVRSNCIAPGAIQGTEGFDRLIGDASKKKTTSKIPLQRLGTTEDIAQATVYLFSPAASYVSGTIQIVDGAMWHIGTHFAHELYPDLLFKDPKAKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRP0</accession>
    <name>DAD4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DAD4</name>
        <name type="ordered locus">CAGL0H07073g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the DASH complex that connects microtubules with kinetochores and couples microtubule depolymerisation to chromosome movement; it is involved in retrieving kinetochores to the spindle poles before their re-orientation on the spindle in early mitosis and allows microtubule depolymerization to pull chromosomes apart and resist detachment during anaphase. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and microtubules. Kinetochores also serve as an input point for the spindle assembly checkpoint, which delays anaphase until all chromosomes have bioriented on the mitotic spindle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 2">Component of the DASH complex consisting of ASK1, DAD1, DAD2, DAD3, DAD4, DAM1, DUO1, HSK3, SPC19 and SPC34, with a stoichiometry of one copy of each subunit per complex. Multiple DASH complexes oligomerize to form a ring that encircles spindle microtubules and organizes the rod-like NDC80 complexes of the outer kinetochore. DASH complex oligomerization strengthens microtubule attachments (By similarity). On cytoplasmic microtubules, DASH complexes appear to form patches instead of rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447104.1">
        <property type="nucleotide sequence ID" value="XM_447104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRP0"/>
    <dbReference type="SMR" id="Q6FRP0"/>
    <dbReference type="FunCoup" id="Q6FRP0">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRP0"/>
    <dbReference type="EnsemblFungi" id="CAGL0H07073g-T">
        <property type="protein sequence ID" value="CAGL0H07073g-T-p1"/>
        <property type="gene ID" value="CAGL0H07073g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888581"/>
    <dbReference type="KEGG" id="cgr:2888581"/>
    <dbReference type="CGD" id="CAL0129896">
        <property type="gene designation" value="CAGL0H07073g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H07073g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07073g"/>
    <dbReference type="eggNOG" id="ENOG502S890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177920_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRP0"/>
    <dbReference type="OMA" id="SQMWANY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051987">
        <property type="term" value="P:positive regulation of attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990976">
        <property type="term" value="P:protein transport along microtubule to mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000176049" description="DASH complex subunit DAD4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P69851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q50HP4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="73" mass="8467" checksum="A6E2A1487DE425F5" modified="2004-07-19" version="1">MVENPYEEVQVNVLSRIIANVEKLNQSVRTLNQELENVNKRNKNLEVMGQICENYHRSVQFNLEATGNKKPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRY0</accession>
    <name>Q6FRY0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Central kinetochore subunit CTF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H05027g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRY0"/>
    <dbReference type="FunCoup" id="Q6FRY0">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRY0"/>
    <dbReference type="KEGG" id="cgr:2888453"/>
    <dbReference type="CGD" id="CAL0131574">
        <property type="gene designation" value="CAGL0H05027g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05027g"/>
    <dbReference type="eggNOG" id="ENOG502QS8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022668_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRY0"/>
    <dbReference type="OMA" id="NYLWRNK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="CDD" id="cd22647">
        <property type="entry name" value="CTF3_NTD_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0131574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="81101" checksum="F15C18F342667B47" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS03</accession>
    <name>RL32_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein eL32</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPL32</name>
        <name type="ordered locus">CAGL0H04521g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446991.1">
        <property type="nucleotide sequence ID" value="XM_446991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS03"/>
    <dbReference type="SMR" id="Q6FS03"/>
    <dbReference type="FunCoup" id="Q6FS03">
        <property type="interactions" value="1042"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS03"/>
    <dbReference type="EnsemblFungi" id="CAGL0H04521g-T">
        <property type="protein sequence ID" value="CAGL0H04521g-T-p1"/>
        <property type="gene ID" value="CAGL0H04521g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888848"/>
    <dbReference type="KEGG" id="cgr:2888848"/>
    <dbReference type="CGD" id="CAL0131998">
        <property type="gene designation" value="CAGL0H04521g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H04521g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04521g"/>
    <dbReference type="eggNOG" id="KOG0878">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071479_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FS03"/>
    <dbReference type="OMA" id="GPHNTAK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000131140" description="Large ribosomal subunit protein eL32">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="131" mass="14780" checksum="97133CFE34994069" modified="2004-07-19" version="1">MAASLPHPKIVKKHTKKFKRHHSDRYHRVSENWRKQKGIDSVVRRRFRGNISEPTIGYGSNKKTKFMSPSGHKVVLVSNLKDLETLTMHTKSYAAEIAHNVSSKNRVTLLARAKALGVKVTNAKGRLALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS96</accession>
    <name>Q6FS96_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H02365g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446898.1">
        <property type="nucleotide sequence ID" value="XM_446898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS96"/>
    <dbReference type="FunCoup" id="Q6FS96">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888810"/>
    <dbReference type="CGD" id="CAL0130356">
        <property type="gene designation" value="CAGL0H02365g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02365g"/>
    <dbReference type="eggNOG" id="KOG3020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FS96"/>
    <dbReference type="OMA" id="VPCFGWH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="298" mass="33935" checksum="BB3B67B1EE7B8B00" modified="2004-07-19" version="1">MLVDAHCHLDGSADSRGCAEYARNVRVCLMSTNPQDAEMLSVGIGLGNAVCAFGVHPWFSHWFYVGDAPGKLEHYSRVMQADAADEGFLSLVDELPDPIDLDQYIRDHFPKGRWQVIGEVGLDKLFRVKRRDGTLSRWHVSMDHQRVVLDRFLDLAVRTGLSVSLHGVKAHGSLLDRCEKKLLNTPCNICLHSYTGPADTLTALWIRKFGHERIFVSLSQYINLDDKHRAVTENILDICPKTCILPETDFEINKHDAQRLEMSLRTVYNFIGQRWGIDNYEELMQTNFESFYGHSIAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSF1</accession>
    <name>RUVB2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>RuvB-like helicase 2</fullName>
            <ecNumber>3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RVB2</name>
        <name type="ordered locus">CAGL0H01001g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">May form heterododecamers with RVB1. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446843.1">
        <property type="nucleotide sequence ID" value="XM_446843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSF1"/>
    <dbReference type="SMR" id="Q6FSF1"/>
    <dbReference type="FunCoup" id="Q6FSF1">
        <property type="interactions" value="1746"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSF1"/>
    <dbReference type="EnsemblFungi" id="CAGL0H01001g-T">
        <property type="protein sequence ID" value="CAGL0H01001g-T-p1"/>
        <property type="gene ID" value="CAGL0H01001g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888577"/>
    <dbReference type="KEGG" id="cgr:2888577"/>
    <dbReference type="CGD" id="CAL0132044">
        <property type="gene designation" value="CAGL0H01001g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H01001g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01001g"/>
    <dbReference type="eggNOG" id="KOG2680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028311_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FSF1"/>
    <dbReference type="OMA" id="IINTEPY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000165665" description="RuvB-like helicase 2">
        <location>
            <begin position="1"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="476" mass="52030" checksum="590BE57AC0BB154A" modified="2004-07-19" version="1">MSIQTSDPNDPNGSLKSLSLIAAHSHITGLGLDDNLQPRASSEGMVGQLQARRAAGVILRMIQNGSIAGRAILVAGPPSTGKTALAMGLSQSLGKDVPFTAITGSEIFSLELSKTEALTQAFRKSIGIKIKEETELIEGEVVEIQIDRSITGGHKQGKLTIKTTDMETIYELGNKMIDGLTKEKVLAGDVISIDKASGKITKLGRSFARSRDYDAMGYDTKFVQCPEGELQKRKTVVHTVSLHEIDVINSRTQGFLALFTGDTGEIRSEVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDEFAPIIMMATNRGISKTRGTNYKSPHGLPLDLLDRSIIITTSNYNEEEIKTILTIRAQEEEVELSPDALDLLTKTGGETSLRYSSNLISVAQQIALKRKSNTVEVADVKKAYLLFLDSSRSVKFVQENQDQYIDDNGKVIISTSGEMTQPADGEAMDTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSG7</accession>
    <name>Q6FSG7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2Fe-2S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0H00660g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSG7"/>
    <dbReference type="FunCoup" id="Q6FSG7">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSG7"/>
    <dbReference type="KEGG" id="cgr:2888826"/>
    <dbReference type="CGD" id="CAL0131858">
        <property type="gene designation" value="CAGL0H00660g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00660g"/>
    <dbReference type="eggNOG" id="KOG3309">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082632_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FSG7"/>
    <dbReference type="OMA" id="QSPWQGY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000013">
        <property type="entry name" value="Adrenodoxin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF65">
        <property type="entry name" value="FERREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="11">
        <location>
            <begin position="55"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0131858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="167" mass="18532" checksum="5F671DEE7E970131" modified="2004-07-19" version="1">MQHILRRSIVPISRNIGLSRRFADRPLWQSSARLFSTSMMLSHGHIKKPNPGEELHVTYILKDGSQKTYEVADGDTLLDIAQANNLDMEGACGGSCACSTCHVIVDPDYYDAIPEPEDDENDMLDLAYGLTETSRLGCQVKMSKDIDGIRVALPAMTRNVSNNDFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSG9</accession>
    <name>Q6FSG9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator HFI1/ADA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0H00616g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSG9"/>
    <dbReference type="FunCoup" id="Q6FSG9">
        <property type="interactions" value="1344"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSG9"/>
    <dbReference type="KEGG" id="cgr:2888605"/>
    <dbReference type="CGD" id="CAL0131862">
        <property type="gene designation" value="CAGL0H00616g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00616g"/>
    <dbReference type="eggNOG" id="ENOG502RX84">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033254_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FSG9"/>
    <dbReference type="OMA" id="NWLIKDI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22933">
        <property type="entry name" value="HFD_HFI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21277:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50243" checksum="3DE579D7ED7B9804" modified="2004-07-19" version="1">MTAVQPQMRAMTPSFTGSGGTLTNGNSALFVKNAVGTPISMIDSNQLNDIPSAGNYNSSNLTSNLKLKESLIEDQRVDISSMIEEITGILGRDQWTKYAQILSLFILGKLSRKELVNELDILFSGSNNMKPKMMRLHNHLLLGILANSLRENPLTMIKNGSWGFGNGTNANGKQSKKGNKHNSQIELYKKIVMSLPIEDRNRIKSITKDAGKRGFVFCSVLQSRLNNIPKIPIVTNADTLKRIKNDNMKTPLEWSQDIMNGFGAPLASESYSLPDTDSFYLRIVGIAREHGIVGNIDAGCIDLISLALDVYLKNIIEMAIDTVRYRKKKYSDYYDLDDFGTYQAVSSGTDTSKDAKDDIMEIERKRTISLTNEDIYTSLSLFPNMADASGAYYNAMNLGLVNDDELVIKSSSIDDLPDFLEEKPFFTPVDEKNIGTPTELNWLIRDILTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSK5</accession>
    <name>Q6FSK5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HDA1 complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G09867g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSK5"/>
    <dbReference type="FunCoup" id="Q6FSK5">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSK5"/>
    <dbReference type="KEGG" id="cgr:2888294"/>
    <dbReference type="CGD" id="CAL0137659">
        <property type="gene designation" value="CAGL0G09867g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09867g"/>
    <dbReference type="eggNOG" id="ENOG502QT9V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026579_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSK5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070823">
        <property type="term" value="C:HDA1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021006">
        <property type="entry name" value="Hda2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026216">
        <property type="entry name" value="HDA3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11496">
        <property type="entry name" value="HDA2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02093">
        <property type="entry name" value="HDA1SUBUNIT3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="623"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="481"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="644" mass="74505" checksum="D795E758E3815FD5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSZ1</accession>
    <name>Q6FSZ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="6">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0G06732g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="6"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSZ1"/>
    <dbReference type="FunCoup" id="Q6FSZ1">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSZ1"/>
    <dbReference type="KEGG" id="cgr:2888233"/>
    <dbReference type="CGD" id="CAL0130739">
        <property type="gene designation" value="CAGL0G06732g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06732g"/>
    <dbReference type="eggNOG" id="KOG2367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004588_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FSZ1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF2">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="13">
        <location>
            <begin position="56"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0130739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG59580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="608" mass="67332" checksum="1640C698ECD31504" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSZ2</accession>
    <name>Q6FSZ2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ORI1</name>
        <name evidence="1 2" type="ordered locus">CAGL0G06710g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_446652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSZ2"/>
    <dbReference type="STRING" id="284593.Q6FSZ2"/>
    <dbReference type="KEGG" id="cgr:2888145"/>
    <dbReference type="CGD" id="CAL0130841">
        <property type="gene designation" value="ORI1"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_2542347_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSZ2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0130841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="83" mass="9339" checksum="498A19139442D93E" modified="2004-07-19" version="1">MRFPLPLESQLSPFDYHQVRDKFGFKTPLFALTHFESQTMSSLSGMRGLEENGISTGIAKGYKSTPHVRSWGFLSFLHGVISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT52</accession>
    <name>Q6FT52_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TPS2</name>
        <name evidence="3 4" type="ordered locus">CAGL0G05335g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446592.1">
        <property type="nucleotide sequence ID" value="XM_446592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT52"/>
    <dbReference type="FunCoup" id="Q6FT52">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT52"/>
    <dbReference type="CAZy" id="GT20">
        <property type="family name" value="Glycosyltransferase Family 20"/>
    </dbReference>
    <dbReference type="GeneID" id="2888142"/>
    <dbReference type="KEGG" id="cgr:2888142"/>
    <dbReference type="CGD" id="CAL0129888">
        <property type="gene designation" value="TPS2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05335g"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FT52"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009758">
        <property type="term" value="P:carbohydrate utilization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="890" mass="101836" checksum="DF09917A09730189" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT63</accession>
    <name>Q6FT63_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22" type="ordered locus">CAGL0G05071g</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:14761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="EC" id="2.3.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 18">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="7"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT63"/>
    <dbReference type="FunCoup" id="Q6FT63">
        <property type="interactions" value="433"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT63"/>
    <dbReference type="KEGG" id="cgr:2888433"/>
    <dbReference type="CGD" id="CAL0129293">
        <property type="gene designation" value="CAGL0G05071g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05071g"/>
    <dbReference type="eggNOG" id="KOG1357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_7_2_1"/>
    <dbReference type="InParanoid" id="Q6FT63"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017059">
        <property type="term" value="C:serine palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000047">
        <property type="entry name" value="serine palmitoyltransferase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF3">
        <property type="entry name" value="LD36009P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="20">
        <location>
            <begin position="161"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0129293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG59508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="565" mass="63879" checksum="2B194E11479D73BF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT66</accession>
    <name>NMD4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Nonsense-mediated decay protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NMD4</name>
        <name type="ordered locus">CAGL0G05005g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nonsense-mediated decay of mRNAs containing premature stop codons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446578.1">
        <property type="nucleotide sequence ID" value="XM_446578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT66"/>
    <dbReference type="SMR" id="Q6FT66"/>
    <dbReference type="FunCoup" id="Q6FT66">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT66"/>
    <dbReference type="EnsemblFungi" id="CAGL0G05005g-T">
        <property type="protein sequence ID" value="CAGL0G05005g-T-p1"/>
        <property type="gene ID" value="CAGL0G05005g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887981"/>
    <dbReference type="KEGG" id="cgr:2887981"/>
    <dbReference type="CGD" id="CAL0130793">
        <property type="gene designation" value="CAGL0G05005g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_G05005g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05005g"/>
    <dbReference type="eggNOG" id="ENOG502RYBU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1273151_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT66"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18717">
        <property type="entry name" value="PIN_ScNmd4p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000096876" description="Nonsense-mediated decay protein 4">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <sequence length="244" mass="28254" checksum="28ABD4E4C26F5AA0" modified="2004-07-19" version="1">MNQYNFILDASAFEKGLGNVKRWCQSNGNVDGKKNVYLRFYVPTFTLQELNFLQYRHKSFSAKEALKFIDKLETATSEGQRNHVVIGRKKEEDLRSDLELFIEFPDILDAVTWPTVLSYCTEGQATIDSLNKLPKRFKILLKSCVYKCHLEDDDRIRWILVTEDPQVRKIASQCHIPWCSIVDADSIISKDMNDRSFRDSEKFNSMMLKRGVAKSENMDGKEVIKTNFDQTVYATRGSGKLWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTA5</accession>
    <name>Q6FTA5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0G04059g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTA5"/>
    <dbReference type="FunCoup" id="Q6FTA5">
        <property type="interactions" value="1089"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTA5"/>
    <dbReference type="KEGG" id="cgr:2888065"/>
    <dbReference type="CGD" id="CAL0130683">
        <property type="gene designation" value="CAGL0G04059g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04059g"/>
    <dbReference type="eggNOG" id="KOG2807">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028556_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FTA5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000477">
        <property type="entry name" value="General transcription and DNA repair factor IIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="103"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0130683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG59466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="439" mass="49184" checksum="07D1A63D1575D894" modified="2004-07-19" version="1">MSSDEDEVVRKPRNDDMRKRALRNGNAGKKKKVVKKKKKLANENLQGASGGYAWEDEIKRSWDLVAVEDEGDMATLVASIVEARKKRAAKSDVTPYQRGIIRTLILTIDSSEAMLEKDLRPNRHAMIIQQAIDFVHEFFDQNPISQMGIVTMRNGLAQLVSQVSGNPQDHIDALKSIRKQEPKGNPSLQNALEMARGLLLPVPAHCTREVLIVFGSLSSNDPGDIHQTIASLVQEQIRVKVLGLSAEVAICKELCKQTNMGDTSFYQVLLDETHLKKLFDEAVTPLPVNKINRGFTLVKMGFPTRIFEEQPTFCACHAKLIYGGYFCPNCNSKVCSLPTVCPCCDLMLILSTHLARSFHHLMPLKTFVEVPAAESFPTENCYSCQMKFPIIKSQKSNQMLTSSRYRCEECKNDYCIDCDVFIHESLHTCPGCESKATII</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTJ2</accession>
    <name>RL3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein uL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPL3</name>
        <name type="ordered locus">CAGL0G02079g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446452.1">
        <property type="nucleotide sequence ID" value="XM_446452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTJ2"/>
    <dbReference type="SMR" id="Q6FTJ2"/>
    <dbReference type="FunCoup" id="Q6FTJ2">
        <property type="interactions" value="919"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTJ2"/>
    <dbReference type="EnsemblFungi" id="CAGL0G02079g-T">
        <property type="protein sequence ID" value="CAGL0G02079g-T-p1"/>
        <property type="gene ID" value="CAGL0G02079g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888296"/>
    <dbReference type="KEGG" id="cgr:2888296"/>
    <dbReference type="CGD" id="CAL0129309">
        <property type="gene designation" value="CAGL0G02079g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_G02079g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02079g"/>
    <dbReference type="eggNOG" id="KOG0746">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033361_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FTJ2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000077245" description="Large ribosomal subunit protein uL3">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="387" mass="43842" checksum="BF82A4C770BAE39B" modified="2004-07-19" version="1">MSHRKYEAPRHGHLGFLPRKRAASVRGRVKSFPKDDKSKPVALTSFLGYKAGMTTIVRDLDRPGSKFHKREIVEAVTVVDTPPVVVVGVVGYVETPRGLRSLTTVWAEHLSDEVKRRFYKNWYKSKKKAFTKYSAKYAQNGAEIERELARIKKYATVVRVLVHTQVRKTPLVQKKAHLAEIQLNGGSISEKVDWAREHFEKTVSVDSVFEQNEMIDAIAVTKGHGFEGVTHRWGTKKLPRKTHRGLRKVACIGAWHPAHVMWSVARAGQRGYHHRTSINHKIYRIGKGDDEGNAATNFDRTKKTINPMGGFVHYGMVNNDFVMVKGSIPGCKKRVVTLRKSLYTNTSRKAVEEVTLKWIDTASKFGKGRFQTPAEKHAFMGTLKKDL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-18" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTN2</accession>
    <name>DIC1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial dicarboxylate transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Dicarboxylate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DIC1</name>
        <name type="ordered locus">CAGL0G01166g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Mitochondrial dicarboxylic transporter catalyzing the exchange of dicarboxylic acids like malate and succinate for inorganic phosphate. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. Does not transport glutathione. Required for growth on ethanol and acetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-malate(in) + phosphate(out) = (S)-malate(out) + phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:71607"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446412.1">
        <property type="nucleotide sequence ID" value="XM_446412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTN2"/>
    <dbReference type="SMR" id="Q6FTN2"/>
    <dbReference type="FunCoup" id="Q6FTN2">
        <property type="interactions" value="964"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTN2"/>
    <dbReference type="EnsemblFungi" id="CAGL0G01166g-T">
        <property type="protein sequence ID" value="CAGL0G01166g-T-p1"/>
        <property type="gene ID" value="CAGL0G01166g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888386"/>
    <dbReference type="KEGG" id="cgr:2888386"/>
    <dbReference type="CGD" id="CAL0130061">
        <property type="gene designation" value="CAGL0G01166g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_G01166g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01166g"/>
    <dbReference type="eggNOG" id="KOG0759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_1_1"/>
    <dbReference type="InParanoid" id="Q6FTN2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0050">Antiport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0592">Phosphate transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000233004" description="Mitochondrial dicarboxylate transporter">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="3">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="3">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="3">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="3">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=5" evidence="3">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="3">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar 1" evidence="4">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar 2" evidence="4">
        <location>
            <begin position="96"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar 3" evidence="4">
        <location>
            <begin position="198"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q06143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9UBX3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="295" mass="32976" checksum="DAC73A477F826BF5" modified="2004-07-19" version="1">MSEKQVKYPWWYGGAAGIFAVMNTHPLDLTKVRLQAAPIPKPTIVQMLRSILKNEGIVGLYAGLSASLLRQCTYTTARFGMYDALKEHVIPRDKLTNMWYLLGASMVSGALGGLAGNFADLINIRMQNDSALPLDKRRNYKNAIDGMVKIYKAEGAKSLFLTGWKPNMVRGVLMTASQVVTYDMFKNFLVTKYNMDPKKNSTHLTSSLLAGFVATTVCSPADVIKTIVMNAHKKPGHNHDSSFKILMEAINKEGPSFMFRGWVPSFTRLAPFTMLIFFAMEQLKKYRVGMPKEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTV8</accession>
    <name>Q6FTV8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0F08459g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTV8"/>
    <dbReference type="FunCoup" id="Q6FTV8">
        <property type="interactions" value="1124"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTV8"/>
    <dbReference type="KEGG" id="cgr:2887794"/>
    <dbReference type="CGD" id="CAL0131210">
        <property type="gene designation" value="CAGL0F08459g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08459g"/>
    <dbReference type="eggNOG" id="KOG1247">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FTV8"/>
    <dbReference type="OMA" id="HLNTTEY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10290">
        <property type="entry name" value="GST_C_MetRS_N_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000037">
        <property type="entry name" value="Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018285">
        <property type="entry name" value="Met-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001100">
        <property type="entry name" value="PRK00133.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09635">
        <property type="entry name" value="MetRS-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl-tRNA synthetase N-terminal heteromerisation" evidence="14">
        <location>
            <begin position="11"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="13">
        <location>
            <begin position="197"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="610"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0131210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG59260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="750" mass="85254" checksum="0445A1BC50603217" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTY5</accession>
    <name>GPI10_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>GPI mannosyltransferase 3</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GPI mannosyltransferase III</fullName>
            <shortName>GPI-MT-III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Glycosylphosphatidylinositol-anchor biosynthesis protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GPI10</name>
        <name type="ordered locus">CAGL0F07843g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text>Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446309.1">
        <property type="nucleotide sequence ID" value="XM_446309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTY5"/>
    <dbReference type="FunCoup" id="Q6FTY5">
        <property type="interactions" value="913"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTY5"/>
    <dbReference type="CAZy" id="GT22">
        <property type="family name" value="Glycosyltransferase Family 22"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q6FTY5">
        <property type="glycosylation" value="6 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0F07843g-T">
        <property type="protein sequence ID" value="CAGL0F07843g-T-p1"/>
        <property type="gene ID" value="CAGL0F07843g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887751"/>
    <dbReference type="KEGG" id="cgr:2887751"/>
    <dbReference type="CGD" id="CAL0129444">
        <property type="gene designation" value="CAGL0F07843g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07843g"/>
    <dbReference type="eggNOG" id="KOG1771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012353_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FTY5"/>
    <dbReference type="OMA" id="HEWPDYL"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000246261" description="GPI mannosyltransferase 3">
        <location>
            <begin position="1"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="508"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="612" mass="71387" checksum="625C1A22C15435FD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU26</accession>
    <name>Q6FU26_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0F06897g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446268.1">
        <property type="nucleotide sequence ID" value="XM_446268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU26"/>
    <dbReference type="FunCoup" id="Q6FU26">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU26"/>
    <dbReference type="KEGG" id="cgr:2887806"/>
    <dbReference type="CGD" id="CAL0129324">
        <property type="gene designation" value="CAGL0F06897g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06897g"/>
    <dbReference type="eggNOG" id="KOG1204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_11_1"/>
    <dbReference type="InParanoid" id="Q6FU26"/>
    <dbReference type="OMA" id="SAYPRWG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05367">
        <property type="entry name" value="SPR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0129324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="258" mass="28369" checksum="A70070868AE3A04B" modified="2004-07-19" version="1">MSQTEQKVILVTGVSRGIGKSIVDTLFSLDKNVIVYGIARSEAPLKALKDTYGDRFFYTVGDITNDDTLKKYVNSAIEGHGKINSLIANAGVLEPVQNINNIDVNAWKQLYNINFFSIVSLVDIALPHLKKTHGSALFVSSDASDTYFSSWGAYGSSKAALNHFAMTLANEEKAVRALAVAPGIVDTDMQVNIRENLGPQGMSQEHLEMFRDLKKDNKLLHSSIPATVYSKLALNGIPEEINGQYLSFDAEVLKEFQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUJ6</accession>
    <name>Q6FUJ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">YL23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0F02937g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUJ6"/>
    <dbReference type="FunCoup" id="Q6FUJ6">
        <property type="interactions" value="1126"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUJ6"/>
    <dbReference type="KEGG" id="cgr:2887769"/>
    <dbReference type="CGD" id="CAL0131000">
        <property type="gene designation" value="CAGL0F02937g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02937g"/>
    <dbReference type="eggNOG" id="KOG0886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FUJ6"/>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="11">
        <location>
            <begin position="14"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="10">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00082757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0131000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="165" mass="17753" checksum="1C97BDC6338FF957" modified="2004-07-19" version="1">MPPKFDPNEVKYLYLRAVGGEVGASAALAPKIGPLGLSPKKVGEDIAKATKDFKGIKVTVQLKIQNRQATASVVPSASSLVITALKEPPRDRKKDKNVKHSGNVALDEIIEIARQMKEKSFGKNLASVTKEILGTAQSVGCRVDFKNPHDIIEAINAGEIEIPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUK4</accession>
    <name>Q6FUK4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0F02761g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUK4"/>
    <dbReference type="FunCoup" id="Q6FUK4">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUK4"/>
    <dbReference type="KEGG" id="cgr:2887708"/>
    <dbReference type="CGD" id="CAL0129396">
        <property type="gene designation" value="CAGL0F02761g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02761g"/>
    <dbReference type="eggNOG" id="KOG3076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FUK4"/>
    <dbReference type="OMA" id="HYVDEGM"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0129396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="210" mass="22963" checksum="539BA854954D36A6" modified="2004-07-19" version="1">MKRVTVLISGSGSNLQALLDAEREGKLPGISITHVISSSKKAYGLERAAAAGVPTTIHSLYNYTKSIPKEDVAQKKLARRQFEKDLAQVVLESKPDLVVCAGWLLILGPDFLAILKGIPILNLHPALPGQFDGTTHAIEMAWNKCQEDNKPLKAGCMVHYVIEEVDKGEPLVVKELEIVPGKETLDQYEERVHKAEHVAIVEATLKALAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUN9</accession>
    <name>Q6FUN9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ino eighty subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0F01903g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUN9"/>
    <dbReference type="FunCoup" id="Q6FUN9">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUN9"/>
    <dbReference type="KEGG" id="cgr:2887889"/>
    <dbReference type="CGD" id="CAL0131016">
        <property type="gene designation" value="CAGL0F01903g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01903g"/>
    <dbReference type="eggNOG" id="ENOG502S125">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105947_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUN9"/>
    <dbReference type="OMA" id="KINYEMV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31641" checksum="6C83ACEE567AD9AD" modified="2004-07-19" version="1">MSYEELIKNDLQLQYARNAVRYYKSNTVPEFLEKDPHKKSVIQRLSDTVNSQASSVNVSRNSTPAPSLGPMSTAGSASANTTSNGPGGNVRRHIISVDDSLKINYEMVKNVPGNFPSRIGIRTPDEMDMHEEELQDKLALENEANTVKTKIYKQKLFDDNDTVLELVGTQLSHFQDPHTPSDQSKPRLSLREQLECLQKIQDNLLQDYKDSQKEEKKWFVLKELLLEANTELDLFSSQDYPNKVINLGDGASTSQHSDTALVFNRNKRQKLSNGSYSSIF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUS6</accession>
    <name>NOP12_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NOP12</name>
        <name type="ordered locus">CAGL0F01023g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-25S rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RRM RBM34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446018.1">
        <property type="nucleotide sequence ID" value="XM_446018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUS6"/>
    <dbReference type="SMR" id="Q6FUS6"/>
    <dbReference type="FunCoup" id="Q6FUS6">
        <property type="interactions" value="951"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUS6"/>
    <dbReference type="EnsemblFungi" id="CAGL0F01023g-T">
        <property type="protein sequence ID" value="CAGL0F01023g-T-p1"/>
        <property type="gene ID" value="CAGL0F01023g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887717"/>
    <dbReference type="KEGG" id="cgr:2887717"/>
    <dbReference type="CGD" id="CAL0130862">
        <property type="gene designation" value="CAGL0F01023g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01023g"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006468_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUS6"/>
    <dbReference type="OMA" id="KCTDEQM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12669">
        <property type="entry name" value="RRM1_Nop12p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12670">
        <property type="entry name" value="RRM2_Nop12p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034777">
        <property type="entry name" value="Nop12_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047189">
        <property type="entry name" value="RRM2_Nop12p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF25">
        <property type="entry name" value="RNA-BINDING PROTEIN 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000081667" description="Nucleolar protein 12">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 1" evidence="2">
        <location>
            <begin position="112"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RRM 2" evidence="2">
        <location>
            <begin position="228"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="396" mass="45327" checksum="1D70036456F1BBD0" modified="2004-07-19" version="1">MNLFPETVATDDKVSQLFKTSNALDKKATPLIKVQKIEVIKKTDKDADGDEKMEDAASDDAKVKKPSKKKLAKKNKETKTPEQVPEEPEKLVEEGKESKKSTKEDEIEKASRTIFVGNLSNEVIISKSTYKLFQKLFNNIDDDDENKKLPIQSIRFRSVSFEDALPRKVAFVQQKLHKSRASVNAYIVYKEQSPLLNKLIKRLNGQVFSNRHLRVDSITHPAPHDKQRSVFVGNLDFEEDEESLWKHFGACGSIEYVRIVRDPKTNMGKGFAYVQFNELQSVSKALLLNEKPMISQNEHLKKRKLRVTRCKNIRKVEPTLKSGKYMTDGQKTKLGRAKKILNKAERSKLLKELTVEGIRATKDDSKPVLKKGKKERSKTGRVTKRSQAFKKSQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUW1</accession>
    <name>Q6FUW1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0F00209g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445983.1">
        <property type="nucleotide sequence ID" value="XM_445983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUW1"/>
    <dbReference type="KEGG" id="cgr:2887643"/>
    <dbReference type="CGD" id="CAL0131426">
        <property type="gene designation" value="CAGL0F00209g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00209g"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_0_6_1"/>
    <dbReference type="InParanoid" id="Q6FUW1"/>
    <dbReference type="OMA" id="WILPNFP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="91"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0131426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="540" mass="60696" checksum="8BC216A6B981ED88" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV27</accession>
    <name>Q6FV27_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0E05258g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV27"/>
    <dbReference type="STRING" id="284593.Q6FV27"/>
    <dbReference type="KEGG" id="cgr:2887287"/>
    <dbReference type="CGD" id="CAL0128906">
        <property type="gene designation" value="CAGL0E05258g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05258g"/>
    <dbReference type="eggNOG" id="KOG0860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064620_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FV27"/>
    <dbReference type="OMA" id="VRKKMWW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15874">
        <property type="entry name" value="R-SNARE_Snc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016444">
        <property type="entry name" value="Synaptobrevin/VAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45701">
        <property type="entry name" value="SYNAPTOBREVIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005409">
        <property type="entry name" value="Synaptobrevin_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0128906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="108" mass="12207" checksum="A52572FEA1D62883" modified="2004-07-19" version="1">MASNDNYDPYLLSEDGGQSKAAALKSEIDDTVDIMRNNINKVAERGEMLTSIDDKADNLAMSAQGFKRGANRVRRQMWYKDLKMRMCLFLVIVILLVVIIVPIVVHFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVC7</accession>
    <name>CGR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>rRNA-processing protein CGR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CGR1</name>
        <name type="ordered locus">CAGL0E02937g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CGR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445817.1">
        <property type="nucleotide sequence ID" value="XM_445817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVC7"/>
    <dbReference type="SMR" id="Q6FVC7"/>
    <dbReference type="FunCoup" id="Q6FVC7">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVC7"/>
    <dbReference type="EnsemblFungi" id="CAGL0E02937g-T">
        <property type="protein sequence ID" value="CAGL0E02937g-T-p1"/>
        <property type="gene ID" value="CAGL0E02937g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887426"/>
    <dbReference type="KEGG" id="cgr:2887426"/>
    <dbReference type="CGD" id="CAL0128582">
        <property type="gene designation" value="CAGL0E02937g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_E02937g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02937g"/>
    <dbReference type="eggNOG" id="ENOG502S7VB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125051_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FVC7"/>
    <dbReference type="OMA" id="NGKQWHD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000278950" description="rRNA-processing protein CGR1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="114" mass="14109" checksum="78BAFB2DF8C08DBF" modified="2004-07-19" version="1">MVEEEAKGLPVSKRVWKQEKEPLRANSRVVKNKKLTSWELKKQKRLEEQQYKERLKALKDEKLETKRQQIEAMKLRREKKEEKERYERLAAKMHAKKVERLRRREKRNKALKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVH0</accession>
    <name>Q6FVH0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0E01947g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVH0"/>
    <dbReference type="SMR" id="Q6FVH0"/>
    <dbReference type="STRING" id="284593.Q6FVH0"/>
    <dbReference type="KEGG" id="cgr:2887405"/>
    <dbReference type="CGD" id="CAL0128968">
        <property type="gene designation" value="CAGL0E01947g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01947g"/>
    <dbReference type="eggNOG" id="KOG4205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FVH0"/>
    <dbReference type="OMA" id="HTIMREP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12330">
        <property type="entry name" value="RRM2_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000721">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="206"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="384"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0128968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="452" mass="50283" checksum="F99E615A2E4DB2A4" modified="2004-07-19" version="1">MSSDEEDFNDIYDTKDESKVDAKDDVKAEEKVPEAATSALDQLAALQASSANPDSNKDDAAKMPWETLQNTLNQLQTVTKEESPDKSKEEKSSNASVDSGTNVQSGNTGDRTVKADLSKDSCKMFIGGLNWETTEDGLRDYFSKYGKVEELKIMKDPATGRSRGFGFLTFESASSVDEVVKTQHILDGKVIDPKRAIPREEQDKTGKIFVGGIGPDVRPKEFEEFFAQWGTIIDAQLMLDKDTGRSRGFGFITYDTPDAVDKVCQNKFIDFKGRKIEIKRAAPRHLQKTGGARQPAQQSSNSQYGMGTGSNSSGQYPGYGFQDPMMFSNPMMSGYNPMFANNNPQMQEYFQKMQDYYKQVQQQGGMDYNQMYQQQMQQMAMMMPGFNPSTMGQQSQGSPDANSTKSQSNEASTPTPDDQDRGNKDSSRRSGGPGGFRGRPNDSRRGYHPYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVJ3</accession>
    <name>Q6FVJ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0E01441g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FVJ3">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVJ3"/>
    <dbReference type="KEGG" id="cgr:2887487"/>
    <dbReference type="CGD" id="CAL0128602">
        <property type="gene designation" value="CAGL0E01441g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01441g"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020039_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVJ3"/>
    <dbReference type="OMA" id="HIFGREC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01197">
        <property type="entry name" value="FANCL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="681"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
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        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
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        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
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        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="600"/>
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        </location>
    </feature>
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        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0128602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="717" mass="77178" checksum="2899AAB1757C26FB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVU6</accession>
    <name>Q6FVU6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0D05500g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FVU6">
        <property type="interactions" value="1159"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVU6"/>
    <dbReference type="KEGG" id="cgr:2886971"/>
    <dbReference type="CGD" id="CAL0128387">
        <property type="gene designation" value="CAGL0D05500g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05500g"/>
    <dbReference type="eggNOG" id="KOG2973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037769_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FVU6"/>
    <dbReference type="OMA" id="MCILLTN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061770">
        <property type="term" value="F:translation elongation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="95"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="296"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0128387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="377" mass="43226" checksum="54EDC7FFF4DAC0D2" modified="2004-07-19" version="1">MPTQLEELVSFLHSPQPAVRQIALDNLVGFSTGPSASIFKYDNYRALDDLKVLMKEKSRTLVQQSATVLANLCDDAVMRKKLADDKEFLEYLTWKICDLGNTSSDIMCILLSNLSKEDSITYVFEIVREDNDKDLPPLDKDVFKSKRVIDCLMDCFVKGYDRELNKFANYDYLSYFFADVSRFKIGRTYFIETQEYDGVVPISKLLVFTEKYDSKTRREGVASTIKNSLFDSETHERILTDEEINLLPYILLPIASAKDSEIDEEDMFNLPDELQLLPEDKTRDPVPSIVCTHLESILLLCTTKAAREFMRSKSVYPLIRELHKNVEDEDIGELCYRIVNMLMRGDPNAPVEEMPAKSVEDGDDEDEDDEDALMEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVU9</accession>
    <name>Q6FVU9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ROX1</name>
        <name evidence="6 7" type="ordered locus">CAGL0D05434g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445645.1">
        <property type="nucleotide sequence ID" value="XM_445645.1"/>
    </dbReference>
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    <dbReference type="STRING" id="284593.Q6FVU9"/>
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    <dbReference type="KEGG" id="cgr:2887244"/>
    <dbReference type="CGD" id="CAL0128503">
        <property type="gene designation" value="ROX1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05434g"/>
    <dbReference type="eggNOG" id="KOG0527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1151660_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVU9"/>
    <dbReference type="OMA" id="KEKEWHR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HMG-box_ROX1-like"/>
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    </dbReference>
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        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
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        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FI18025P1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="146"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="146"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0128503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="241" mass="26741" checksum="0D49BAA0F1DF3CDA" modified="2004-07-19" version="1">MQSNVTLPPISQLLATLPSGLESKLVPGASISLTATSCGTPQPQVEAPSSPSSVASNNSSLSTASLSSLSSVCTAKSFFENRAYTTTSAMLNSNAVHKKMSFSEDLRTTPLTAQNIALRGLEMNREKSNVSSMSSAVTKAASPRHIPRPRNAFILFRQHMHRKLFPKLTKDKQKSSDNSSSFKTNSECSREIGQKWRNLDPEEKKYWNELARKEKEWHRMKYPNYKYTPTKKNANSSPLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW11</accession>
    <name>Q6FW11_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0D03850g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="cgr:2887260"/>
    <dbReference type="CGD" id="CAL0128403">
        <property type="gene designation" value="CAGL0D03850g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03850g"/>
    <dbReference type="eggNOG" id="ENOG502QWTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017671_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW11"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX PROTEIN RSC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0128403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="834" mass="95539" checksum="20F95C712C4B99B5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWC6</accession>
    <name>Q6FWC6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0D01232g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWC6"/>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWC6"/>
    <dbReference type="KEGG" id="cgr:2887223"/>
    <dbReference type="CGD" id="CAL0128495">
        <property type="gene designation" value="CAGL0D01232g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01232g"/>
    <dbReference type="eggNOG" id="KOG4504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053195_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWC6"/>
    <dbReference type="OMA" id="SHKSNDV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Putative vacuolar sorting receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273567" description="MRH domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="9">
        <location>
            <begin position="32"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0128495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="329" mass="37476" checksum="C2053F243D9C3011" modified="2004-07-19" version="1">MLLSCLLLLLSCLPIKAAKAEDNEKPFCAVMNPLTGTYIDLSQLSTSPNEEFQMTQRRNNKKTKSNKTRWLVKDWEGKTNFTLSVCSSPVVSKEEKDQLSNTTGAFYVVNDTEHGYTMKYVSIGDFSSEPRLTGIYDTRVLTLKYENGSMCPNGKDRKATLLNFICDKTVSSKAQISYVGNLHECSYFFEIRSVYACPTSNKTNEVNVYGIFISIIVIFFMVEYACRKWLFKDGSVKSVRLHDNYSSSTTSFARDDMRWEMNRHNRSLWKTIPMKVFGGTFRFVGSVVGGLLTKNNSRAQYSAVSTNQQSPFYRDMEEQNDILDSLDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWR0</accession>
    <name>Q6FWR0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional repressor Tup1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TUP1</name>
        <name evidence="9 10" type="ordered locus">CAGL0C03608g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAG58240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_445334.1"/>
    </dbReference>
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    <dbReference type="STRING" id="284593.Q6FWR0"/>
    <dbReference type="GeneID" id="2886749"/>
    <dbReference type="KEGG" id="cgr:2886749"/>
    <dbReference type="CGD" id="CAL0127654">
        <property type="gene designation" value="TUP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03608g"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_23_1"/>
    <dbReference type="InParanoid" id="Q6FWR0"/>
    <dbReference type="OMA" id="HYLVPYN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="376"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="411"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="452"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="502"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="557"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="599"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0127654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="643" mass="70510" checksum="7C4F1C67ECF6570D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWU5</accession>
    <name>Q6FWU5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0C02805g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWU5"/>
    <dbReference type="FunCoup" id="Q6FWU5">
        <property type="interactions" value="1110"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWU5"/>
    <dbReference type="KEGG" id="cgr:2886857"/>
    <dbReference type="CGD" id="CAL0127476">
        <property type="gene designation" value="CAGL0C02805g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02805g"/>
    <dbReference type="eggNOG" id="KOG1533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FWU5"/>
    <dbReference type="OMA" id="ATHNYFL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0127476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="347" mass="40087" checksum="2A9DE15BF1007856" modified="2004-07-19" version="1">MPFGQIVIGPPGSGKSTYCNGCSQFFNAIGRHAQIVNMDPANDKLPYPCAVDIRDFITLEEIMSEQQLGPNGGLMYAIESLDKSIDMFILQIKSLVEQEKAYVVFDCPGQVELFTHHSALFHVFKRLERDLKIRLCVVNLIDCHYLTSPTQYISILLLALRSMLMMDLPQINVFSKIDMIKSYGELPFRLDYYTEVQDLDYLMPHIEKENNTLMAKRYSKLTETISELVSDFNLVSFEVLAVDDKESMINLQSIVDKANGYIFGSSEVGGDTVWAEATREGALIANYDIQDRWIDNKEMYDKMEQERRAEILRDREMQEKEVDVDNEDEWEAALREWEEKQNTDYVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-25" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWV2</accession>
    <name>ATP10_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial ATPase complex subunit ATP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATP10</name>
        <name type="ordered locus">CAGL0C02651g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in assembly of the mitochondrial F1-F0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445292.1">
        <property type="nucleotide sequence ID" value="XM_445292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWV2"/>
    <dbReference type="SMR" id="Q6FWV2"/>
    <dbReference type="FunCoup" id="Q6FWV2">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWV2"/>
    <dbReference type="EnsemblFungi" id="CAGL0C02651g-T">
        <property type="protein sequence ID" value="CAGL0C02651g-T-p1"/>
        <property type="gene ID" value="CAGL0C02651g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886914"/>
    <dbReference type="KEGG" id="cgr:2886914"/>
    <dbReference type="CGD" id="CAL0127364">
        <property type="gene designation" value="CAGL0C02651g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_C02651g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02651g"/>
    <dbReference type="eggNOG" id="KOG4614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047290_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FWV2"/>
    <dbReference type="OMA" id="YFPNFHG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000071725" description="Mitochondrial ATPase complex subunit ATP10">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="273" mass="31628" checksum="5D32166333E2B7A5" modified="2004-07-19" version="1">MRVVFQQCTKFSTSCNRAFLARFLKPVMNASPKEHVVKQLLKPVGLNVPPRPNIKYSEGNSWLDLFDGAKTEERIKELEIEFAKSGMYEMATFRKTNGKLFLSPESYWKADKALYFPHLSGRTLSSEDHGNVEDVLRGKTSVIRVFSTQVGDKISREYIKNTELGIDNYENQSCQVIDINFLENKLKSWLFKLSLNNLKSTVPVQRHDNYWLCHREQIPFLMRERLLINNVYSGYIFVVDPNLKIRFMACGPASADEFNKLWKVVGQLSKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX37</accession>
    <name>Q6FX37_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">SWI5-dependent HO expression protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SHE3</name>
        <name evidence="13 14" type="ordered locus">CAGL0C00583g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SHE3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445207.1">
        <property type="nucleotide sequence ID" value="XM_445207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX37"/>
    <dbReference type="STRING" id="284593.Q6FX37"/>
    <dbReference type="GeneID" id="2886844"/>
    <dbReference type="KEGG" id="cgr:2886844"/>
    <dbReference type="CGD" id="CAL0127506">
        <property type="gene designation" value="CAGL0C00583g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00583g"/>
    <dbReference type="eggNOG" id="ENOG502QSQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_707870_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX37"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031398">
        <property type="entry name" value="She3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17078">
        <property type="entry name" value="SHE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0127506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG58111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="390" mass="43712" checksum="4BAE9EC02880B6A9" modified="2004-07-19" version="1">MAENTSPTKLGQQYNLHVMNMQSPNRFDFENEDTRNSTSGSVYGTDNERDIWSANARGTPLSFSSSGNNDGDSAKADASTLPSASFGGGGSNISSKVIESLNVQVDTLSNTNLQLTSQYQEVLKKLQDAVDREAEWSETVSKLQVHNREINTALEDKTAELKECDNNLLAIKKEYEQITTENSKLASDYKELSKSLGSLRGQYAKSKIRKNILQSLQEEYKQACNDEIEAVRNNLDMVESKIGHYNSDEKQKLDDILDAHSVLEKEVTSRKLENETAIEELETKWNDLSTKVHLESITEHYSSFKSELTELCEKMDIPVKQFPQTTRNRTPNMVMERSRFRKPTPDASKRASFYGITSPMLQQGFKIPDVASSSAGKPKNSVLPGVKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX91</accession>
    <name>Q6FX91_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0B00792g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX91"/>
    <dbReference type="STRING" id="284593.Q6FX91"/>
    <dbReference type="KEGG" id="cgr:2886602"/>
    <dbReference type="CGD" id="CAL0127048">
        <property type="gene designation" value="CAGL0B00792g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B00792g"/>
    <dbReference type="eggNOG" id="KOG2590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039873_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX91"/>
    <dbReference type="OMA" id="FYRIVNM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="258"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="396"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0127048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG57905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="445" mass="50571" checksum="9E1E5298790088B1" modified="2004-07-19" version="1">MSAEVVTEVPQETKKEVKKELIPAPAPVTSPWKSTATAESMPELKVAELLEETRKRKNKSPQPAIKSSANTKWVPIQVSITVSNNVNSNNNRKNNNRKTRQTPKRAPSGPSNSNQQAKQSTPNSESKQNQQQQEAPQQTQNEKPVAPSMAEAKKTEEIASEQPQSQQSQTTQKPYTNQRRRYNNSPNTHTTKQFRPSSNNSNSTFNNGEAPRHPQHNNRYNKHSNRAQYSGYRSHNHHYNNRYQNRQMVKIDQSFYPLQPAMMAINNVARQIEYYFSADNMNKDEFLKTKLSKDGYAPLELISKFYRLVNMSFGGDQNIILAALREIVNNAEATVEVAIAGEQSSETEQAESLLTKYYIRSKEFSQWVPETVTNEFVAETILTEGSLERFMAQVITPPPRSYNHHKTTPENQTEDESSKESNEGETEKSDESVVQQPESSSTEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXF0</accession>
    <name>Q6FXF0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0B02453g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXF0"/>
    <dbReference type="FunCoup" id="Q6FXF0">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXF0"/>
    <dbReference type="KEGG" id="cgr:2886694"/>
    <dbReference type="CGD" id="CAL0127670">
        <property type="gene designation" value="CAGL0B02453g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B02453g"/>
    <dbReference type="eggNOG" id="KOG3886">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044099_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FXF0"/>
    <dbReference type="OMA" id="QQKDHIF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000006">
        <property type="entry name" value="GTR1p Cytoplasmic GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0127670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG57977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="316" mass="36214" checksum="82FFBD4AFAEE1C35" modified="2004-07-19" version="1">MDDGGNRKKLLLMGRSGSGKSSMRSIIFSNYSAFDTRRLGVTMDVEHSHLRFLGNMTLNLWDCGGQDVFMENYFSKQKDHIFQMVQVLIHVFDVESQEVMKDIEIFTRALRQLRKYSPDAKIFVLLHKMDLVQLDKREELFRLMMKKLKETSADYGFPDLVGFATSIWDESLYRAWSQIVCSLIPNMSVHQSNLKKLKQVMDAYEIILFEKTTCLVICSSNDPGSATTTTTTTSAPTSTTIDKLDPKRFEKISSIMKNYKESCTKLKSGFKNLVLNDNIYVSELSSNMVCFIVLNNSNESHQLVSENIKKASQFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXG6</accession>
    <name>Q6FXG6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ILV5</name>
        <name evidence="21 22" type="ordered locus">CAGL0B03047g</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445105.1">
        <property type="nucleotide sequence ID" value="XM_445105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXG6"/>
    <dbReference type="FunCoup" id="Q6FXG6">
        <property type="interactions" value="789"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXG6"/>
    <dbReference type="GeneID" id="2886604"/>
    <dbReference type="KEGG" id="cgr:2886604"/>
    <dbReference type="CGD" id="CAL0127068">
        <property type="gene designation" value="ILV5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03047g"/>
    <dbReference type="eggNOG" id="ENOG502QQBF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FXG6"/>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="19">
        <location>
            <begin position="61"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="20">
        <location>
            <begin position="251"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0127068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG58005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="399" mass="44568" checksum="E2241C86A034D728" modified="2004-07-19" version="1">MIRAQASRLICNSRVITSKRTFALAARAASMRPAASLMAQKSIKPIVATRGIKQINFGGTVETVYERADWPREKLLNYFANDTFALIGYGSQGYGQGLNLRDNGLNVIIGVRKDGASWKAAIEDGWVPGENLFEVEEAVKKGTYVMNLLSDAAQSETWNSLKPLLTKGKTLYFSHGFSPVFKDLTHVEPPKDIDVILVAPKGSGRTVRSLFKEGRGINSSYAVWNDVSGKAHEKAQALAVAVGSGYVYQTTFEKEVNSDLYGERGCLMGGIHGMFLAQYEVLRENGHSPSEAFNETVEEATQSLYPLIGKYGMDYMYDACSTTARRGALDWYPIFKDALKPVFQDLYESTKNGSETKRSLEFNSQPDYREKLESELQTIRDMEIWRVGKEVRKLRPENQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXI4</accession>
    <name>Q6FXI4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Central kinetochore subunit CHL4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0B02673g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXI4"/>
    <dbReference type="FunCoup" id="Q6FXI4">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXI4"/>
    <dbReference type="KEGG" id="cgr:2886675"/>
    <dbReference type="CGD" id="CAL0127732">
        <property type="gene designation" value="CAGL0B02673g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B02673g"/>
    <dbReference type="eggNOG" id="ENOG502QVRZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031572_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXI4"/>
    <dbReference type="OMA" id="HPASLRW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0127732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG57987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="54370" checksum="D4B9E67466C9B0E2" modified="2004-07-19" version="1">MELEDTYVPKLKDDIIYRKLNRLKVDQLCELSVKWTRKFGAGSQDPISVEEVKQTIEGYLAQQVNKKTVIAQMMYVYWPMGLNAYQLAEIDCILLMERPANYSWKSKYLKNSLTGQNSNFSMNPKKFVSALKNELTKLYLTHFFLCQHAVLPVLILRIQSYDTNNLFLSSVKRNRIILNEEIFEQKLIKSKENQLISRKPYYLVFGINTPFIIHSPENDIYASFIHDCIERVLSFRDPIILEEKTKTPILNLEKILIIDGPSRYSKAMGQWSKYAEGQVETTPFGDIESHESYKGRRILVRKIHDLDDLDEVNHEDRDTKRLRLQKNMIRFKGSENGIIHEKIFEIKKKIDKVYNLSQKQSNILLSKYTSLLPMKKAHYTVTNDNWSGPYNKEDEDVDIAIIEGESDKGSQSISLKLIGNDIFGGLHELCDRNLIDIEHMPGWLTGENGASSGIIKNNEFTATVSPKSGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXK5</accession>
    <name>Q6FXK5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0B03201g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXK5"/>
    <dbReference type="FunCoup" id="Q6FXK5">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886529"/>
    <dbReference type="CGD" id="CAL0127804">
        <property type="gene designation" value="CAGL0B03201g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03201g"/>
    <dbReference type="eggNOG" id="ENOG502RZH0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079711_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXK5"/>
    <dbReference type="OMA" id="MEELYVY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0127804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="318" mass="36982" checksum="E2B27DECADEEEF27" modified="2004-07-19" version="1">MSGETVYVRGENGEVVRLSQVLACEDSKELVNYFWGIQDSRMVKFKCSETIADNLKVEVFLGNTHIKSGMPFYIVEFNDSDEEFSVWRSDGQWGADEAVVQGWYDTLHGNHRSAKKTKSDDWREFVGTKRMQEHPNKIELENSLKKLNVDWSNCNASVFWKEIDNHCRVDAKQASKHATASTEGFHHIVLLALIKAELSKNKHVIKNQIDAFHARMSRKHRFRKSRKDSIMESISEDSCEDEEMIRVRSLSPNYTTATHSPRAVEDIDNETSKQIMSNFNMLFKPIVENFEDVYLDKYSKYPERKRRKQATNRVSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXM2</accession>
    <name>Q6FXM2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0B04675g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445173.1">
        <property type="nucleotide sequence ID" value="XM_445173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXM2"/>
    <dbReference type="STRING" id="284593.Q6FXM2"/>
    <dbReference type="KEGG" id="cgr:2886584"/>
    <dbReference type="CGD" id="CAL0127146">
        <property type="gene designation" value="CAGL0B04675g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04675g"/>
    <dbReference type="eggNOG" id="KOG2869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023334_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FXM2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0127146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="396" mass="44920" checksum="3B43997137052643" modified="2004-07-19" version="1">MKVVSIDKGKSERGRTVLTIVPEDKEDLFAMYQIIDIGDVVIFKKLYTNKSEDTNKKTVTDLARIKLKILNREFDIKDEYLRYKGISCPDESGTENIDSEVPIGKYISFSIVYNHPITIYKSHFNKYAEQLLAEACEPESQADTAAVVLQEGISHICLLTASSTILKQKVEFSMPKKKNAKDVEKFEAKMEKFYRATYDAIVKQLDFDQIRMVIICSPGFYAKTLLTNIMKYASQDQNDLILKNEAIFVVAHCSTGYLQGISEVLKNPEYASLLEDTKFVKEALIFDDFLEHIETEDDKAWYGKTEIYKAAEMEAIDTLLITSNTLRSDDIAEREKNMDLIEQIKAQNGKVIVFSNFRDSGVELQHIGGFACLLKYPVPDLDDLANDAPPDTLITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXQ1</accession>
    <name>Q6FXQ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0B03993g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXQ1"/>
    <dbReference type="FunCoup" id="Q6FXQ1">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXQ1"/>
    <dbReference type="KEGG" id="cgr:2886651"/>
    <dbReference type="CGD" id="CAL0127802">
        <property type="gene designation" value="CAGL0B03993g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03993g"/>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FXQ1"/>
    <dbReference type="OMA" id="STQGRNM"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="53"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="388"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0127802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG58044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="583" mass="62580" checksum="2F99794A6480F9B4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXZ7</accession>
    <name>Q6FXZ7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GIT1</name>
        <name evidence="10 11" type="ordered locus">CAGL0A01243g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444825.1">
        <property type="nucleotide sequence ID" value="XM_444825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXZ7"/>
    <dbReference type="FunCoup" id="Q6FXZ7">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXZ7"/>
    <dbReference type="GeneID" id="2886451"/>
    <dbReference type="KEGG" id="cgr:2886451"/>
    <dbReference type="CGD" id="CAL0126807">
        <property type="gene designation" value="GIT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01243g"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_46_12_1"/>
    <dbReference type="InParanoid" id="Q6FXZ7"/>
    <dbReference type="OMA" id="IMFTNFQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001406">
        <property type="term" value="F:glycerophosphodiester transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="67"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0126807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG57716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="531" mass="58808" checksum="1BBBF133BAF79FEE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY44</accession>
    <name>Q6FY44_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase subunit f, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0A03036g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY44"/>
    <dbReference type="FunCoup" id="Q6FY44">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY44"/>
    <dbReference type="KEGG" id="cgr:2886345"/>
    <dbReference type="CGD" id="CAL0126635">
        <property type="gene designation" value="CAGL0A03036g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A03036g"/>
    <dbReference type="eggNOG" id="ENOG502S739">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152700_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FY44"/>
    <dbReference type="OMA" id="TIDYQMH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0126635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG57791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="11226" checksum="E09D010A2A8C0055" modified="2004-07-19" version="1">MIFKRAVSTLIPPKVVSAQQLGAAPNAKRIANVVSFYKSLPQGPATAANNAGYGRFLGKYKSKYYDGENASGKPIWHLSLAVITFGYSLEYFFHLRHHKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY99</accession>
    <name>Q6FY99_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Heme-binding protein HMX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAGL0A03905g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY99"/>
    <dbReference type="FunCoup" id="Q6FY99">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY99"/>
    <dbReference type="KEGG" id="cgr:2886403"/>
    <dbReference type="eggNOG" id="KOG4480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049906_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY99"/>
    <dbReference type="OMA" id="YYVFDAI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000343">
        <property type="entry name" value="Haem_Oase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG57829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32669" checksum="DEB3B26C95185860" modified="2004-07-19" version="1">MSVRFAVALRHGKLYRQGILAFYYVFQAIEQEIDALLSIDTATGATGATDVSDQKLLASKIVKQFWMPEFRRTEQLYKDLLLLYSPEYPTSTELDAMLVDHQLPPQLQGFVDMVHATVRQNPVTVLAYCHVMYLALFAGGKVMRSTLYRNTGLFPKFEHLSSKELARKGTNFFTFSDAGVDVENQLKWQYKKNYELATREALAENDKLEIIDVAKRIFERNMDIIQEIGQLNKEALTNNKLDLLQYVFEELKFYNKDRSHQQLVYAVLVLLALLVLYRIVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>B4UMX0</accession>
    <name>B4UMX0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EPA10</name>
        <name evidence="4 5" type="ordered locus">CAGL0A01284g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAR57994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002999510.1">
        <property type="nucleotide sequence ID" value="XM_002999464.1"/>
    </dbReference>
    <dbReference type="SMR" id="B4UMX0"/>
    <dbReference type="STRING" id="284593.B4UMX0"/>
    <dbReference type="GeneID" id="9487958"/>
    <dbReference type="KEGG" id="cgr:9487958"/>
    <dbReference type="CGD" id="CAL0126693">
        <property type="gene designation" value="EPA10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01284g"/>
    <dbReference type="eggNOG" id="ENOG502RW40">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254288_0_0_1"/>
    <dbReference type="InParanoid" id="B4UMX0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002827128" description="PA14 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="128"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="888"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0126693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAR57994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1401" mass="148103" checksum="ACCCADD5EF36C0A8" modified="2008-09-23" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN22</accession>
    <name>B4UN22_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAGL0I10246g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAR58038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN22"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I10246g"/>
    <dbReference type="eggNOG" id="ENOG502SFJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_266781_0_0_1"/>
    <dbReference type="InParanoid" id="B4UN22"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049451">
        <property type="entry name" value="AWP2-like_YTTT_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20646">
        <property type="entry name" value="Hpf1_C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002824255" description="PA14 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="44"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1085"/>
            <end position="1107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAR58038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1240" mass="135199" checksum="C00810F94F7CC671" modified="2008-09-23" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-02-08" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN34</accession>
    <name>SPG4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Stationary phase protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SPG4</name>
        <name type="ordered locus">CAGL0K03459g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stationary phase-essential protein not required for growth on nonfermentable carbon sources.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAR58050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002999577.1">
        <property type="nucleotide sequence ID" value="XM_002999531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN34"/>
    <dbReference type="SMR" id="B4UN34"/>
    <dbReference type="FunCoup" id="B4UN34">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0K03459g-T">
        <property type="protein sequence ID" value="CAGL0K03459g-T-p1"/>
        <property type="gene ID" value="CAGL0K03459g"/>
    </dbReference>
    <dbReference type="GeneID" id="9488029"/>
    <dbReference type="KEGG" id="cgr:9488029"/>
    <dbReference type="CGD" id="CAL0134707">
        <property type="gene designation" value="CAGL0K03459g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K03459g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03459g"/>
    <dbReference type="eggNOG" id="ENOG502S7JY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2158879_0_0_1"/>
    <dbReference type="InParanoid" id="B4UN34"/>
    <dbReference type="OMA" id="AHEYREP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020485">
        <property type="entry name" value="Spg4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17325">
        <property type="entry name" value="SPG4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000405000" description="Stationary phase protein 4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="94" mass="10753" checksum="77C5D7D00E5640B8" modified="2008-09-23" version="1">MPSFWDSFAVYNRNKHAKGDVHGGHMSQNMGGQPMYLQAKEHADIKKKEDGTLEAKIETPDGPRLVDVSNMTQQEFERTYNSLRKGEPNNRVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIN7</accession>
    <name>Q6FIN7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M12969g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449907.1">
        <property type="nucleotide sequence ID" value="XM_449907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIN7"/>
    <dbReference type="FunCoup" id="Q6FIN7">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIN7"/>
    <dbReference type="KEGG" id="cgr:2891197"/>
    <dbReference type="CGD" id="CAL0136727">
        <property type="gene designation" value="CAGL0M12969g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M12969g"/>
    <dbReference type="eggNOG" id="ENOG502S01E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072880_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIN7"/>
    <dbReference type="OMA" id="EHIMKDP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012470">
        <property type="entry name" value="Pup1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07954">
        <property type="entry name" value="DUF1689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0136727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="339" mass="38964" checksum="67995C57612B6641" modified="2004-07-19" version="1">MADNKGDVKAPPSWLNSPAFQESYQKAIEFYEKDEVLDARDRLELSKKYTSIARAQFIGGWAGFSAVFITPFAYRYYKTGAIRGVKVPRNFVFGLVAMVVSTQLSGSMMYKKKLQELDPTGELAAKYESKINKNKQRNQYGDFEADVPTLIDENQNQNPPSRYQKEFDMMNLLKNGSAPKWAMYFYTTYQNPRRRFPNPVEMMDELKKAQRQPLAPFLHQRDPFGLFKDQNEKNDEKNDAYPNPTKNAKPADNNQLPLEPPKPELSWNKVRQQNSGKATTAWDRIRNGEHLNDNNDGFDDDLDPFEESKSNVGPTINKPTKEEFKNLVEQERNGGSGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIX2</accession>
    <name>Q6FIX2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M11066g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449822.1">
        <property type="nucleotide sequence ID" value="XM_449822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIX2"/>
    <dbReference type="STRING" id="284593.Q6FIX2"/>
    <dbReference type="KEGG" id="cgr:2891390"/>
    <dbReference type="CGD" id="CAL0136837">
        <property type="gene designation" value="CAGL0M11066g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11066g"/>
    <dbReference type="eggNOG" id="KOG0653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020695_12_3_1"/>
    <dbReference type="InParanoid" id="Q6FIX2"/>
    <dbReference type="OMA" id="IMEYSIC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="105"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="6">
        <location>
            <begin position="198"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="202"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="333" mass="38379" checksum="5B35920C1706A955" modified="2004-07-19" version="1">MDMDKRVERVPLAEVRASNVLSQPVTISSSKRKLEVYDGEETPAKKVKVVDQVAIRDVATVPEYSTDIFKNLFKSEEDTIPSHNYLLDEKSEYHIRANMRAILVDWLVDVHRNFKCLPETLLLAINILDRVLSSTKVSVSKLQLVAVTSLFIACKYEEVKLPKIANFAYITDGAATVEDIREAEFNILETLRFNINWPNPLNFLRRLSQIDDYNYELRDIAKFVLEFIMCTHYFVNYKPSFLSAMAIYLSKRICNDESSNHNEGILTTWSATHTEYSGGINPNNDPKFNDSLNVLIDEFKQPSNSTKSLLAKYKANTYHGMFFRVQDWCLNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ11</accession>
    <name>Q6FJ11_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAGL0M10043g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ11"/>
    <dbReference type="FunCoup" id="Q6FJ11">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ11"/>
    <dbReference type="ESTHER" id="canga-q6fj11">
        <property type="family name" value="Duf_676"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891347"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007367_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ11"/>
    <dbReference type="OMA" id="FSNIGCD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00741">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF20">
        <property type="entry name" value="LIPASE YDR444W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
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    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
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            <end position="406"/>
        </location>
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            <begin position="425"/>
            <end position="465"/>
        </location>
    </feature>
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            <begin position="484"/>
            <end position="522"/>
        </location>
    </feature>
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            <begin position="425"/>
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        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62761.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="658" mass="74916" checksum="2DC835D9F95912DE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ53</accession>
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        <recommendedName>
            <fullName evidence="12">Protein JSN1</fullName>
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        <name evidence="9 10" type="ordered locus">CAGL0M09108g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAG62717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="Q6FJ53"/>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ53"/>
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        <property type="gene designation" value="CAGL0M09108g"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09108g"/>
    <dbReference type="eggNOG" id="KOG4574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009728_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ53"/>
    <dbReference type="OMA" id="TWACQKI"/>
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        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032473">
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0009277">
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        <property type="term" value="P:establishment of mitochondrion localization"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
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    </dbReference>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
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    </dbReference>
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        <property type="entry name" value="ARM-type_fold"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="Pumilio_domain_protein"/>
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        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PUM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="339"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="8">
        <location>
            <begin position="534"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="597"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="5">
        <location>
            <begin position="670"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="477"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="891"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1052"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="891"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="921"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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        </location>
    </feature>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="1099"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0137057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122419" checksum="0AA847D40940A5CD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJC1</accession>
    <name>Q6FJC1_CANGA</name>
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        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PEX12</name>
        <name evidence="18 19" type="ordered locus">CAGL0M07469g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449673.1">
        <property type="nucleotide sequence ID" value="XM_449673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJC1"/>
    <dbReference type="FunCoup" id="Q6FJC1">
        <property type="interactions" value="577"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJC1"/>
    <dbReference type="GeneID" id="2891722"/>
    <dbReference type="KEGG" id="cgr:2891722"/>
    <dbReference type="CGD" id="CAL0137335">
        <property type="gene designation" value="PEX12"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07469g"/>
    <dbReference type="eggNOG" id="KOG0826">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031067_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJC1"/>
    <dbReference type="OMA" id="QHYLARC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044721">
        <property type="term" value="P:protein import into peroxisome matrix, substrate release"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000659">
        <property type="entry name" value="Peroxisome assembly protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="33"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0137335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG62649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="425" mass="48395" checksum="82387C1A72868E9F" modified="2004-07-19" version="1">MSFFSNLPATATSNSGEGVSSLFPTIFEIVSSQEIDELLPASIRYILTNYWISRYPSWTTLQVNNYFEEWFGVGVQGLVEWYHIDKYNSTFVDKFYGLQRFNNSDPVLTQAQAIRQAREAGNPNLQWPKSLQLTNGQKRVVFLQKIILPYISHRLSEVYNKLKSRIAMLSTELDDETGGADKKTKLKRFVIKWFVRLYPLWNSLTSLLNMVVKLAFLTGRTGSMTFLEYLFKIEYTRMTLPLENGSISPSKTLKNNERPTRTNMSSIRGIFESAIGSLGGMAGLTGSQLFPAFIFMLRVYQWWNTEDLTTKLQKKLNDIDKDIPRPPNAHISEEASNDSFEDSEMSQISEKIGTKKSDICPICKDSIENPCVLETGYVTCYACALDYIPKHEGRCPVTGKRLLGCQFDSESGEWKVVTGIRRLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJK3</accession>
    <name>Q6FJK3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">YFH1</name>
        <name evidence="13 14" type="ordered locus">CAGL0M05643g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449591.1">
        <property type="nucleotide sequence ID" value="XM_449591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJK3"/>
    <dbReference type="FunCoup" id="Q6FJK3">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJK3"/>
    <dbReference type="GeneID" id="2891639"/>
    <dbReference type="KEGG" id="cgr:2891639"/>
    <dbReference type="CGD" id="CAL0137115">
        <property type="gene designation" value="YFH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05643g"/>
    <dbReference type="eggNOG" id="KOG3413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080880_2_4_1"/>
    <dbReference type="InParanoid" id="Q6FJK3"/>
    <dbReference type="OMA" id="PNRYDYY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010040">
        <property type="term" value="P:response to iron(II) ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0137115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG62567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="176" mass="19827" checksum="938CB0FEC988514F" modified="2004-07-19" version="1">MIRNILRRSAARVRIPVTSATCASRLVMSIRLATSTRYYSNGNEGGPAMTNGVQIPKEVLELPLQQYHQHSESFLEGLFDNLEELSENYPQHIPEVEYSHGVMSLTVAGVGTYVINKQPPNKQIWLSSPNSGPNRFDLYKGEWISLRNNETLLSVLDKELHDALPNDAEFKVESDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJK4</accession>
    <name>Q6FJK4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">inositol phosphorylceramide mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.370</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0M05621g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1&lt;-&gt;6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:155885"/>
            <dbReference type="ChEBI" id="CHEBI:155926"/>
            <dbReference type="EC" id="2.4.1.370"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:64597"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.370" evidence="8"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJK4"/>
    <dbReference type="FunCoup" id="Q6FJK4">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="CAZy" id="GT32">
        <property type="family name" value="Glycosyltransferase Family 32"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891638"/>
    <dbReference type="CGD" id="CAL0137251">
        <property type="gene designation" value="CAGL0M05621g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05621g"/>
    <dbReference type="eggNOG" id="ENOG502QS3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036369_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FJK4"/>
    <dbReference type="OMA" id="EYLFYSW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103064">
        <property type="term" value="F:inositol phosphorylceramide mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0137251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="441" mass="51189" checksum="6FAB447A6F1C5195" modified="2004-07-19" version="1">MKKELKLLIYANFMLVVFILYYTFDLLMLCIDDTFQDALLDFELNPPRDRVTGLEVHDGKPELIPKIIHQTYKTEDIPEQWKESQKKCIDLHPDYEYILWTDEMALKFIKEEYAWFLDTFENYKYPIQRADAIRYFILSHYGGIYIDLDDGCERRLDPLLKVPAFVRKTSPLGVSNNVMGSVPRHPFYLKLLNSLKHYDKYWFIPYLTIMGSTGPLFVSVIWKQYKRWGVPENGVVRIMQPADYKKHTYSFFSISKGSSWHMDDAVFMKSLENHILSCVVAGFIVGFIILYGEYVFYCWLCASWLGSSNDPEAESQDDEDDFIYNKGSQYYQQGHGSIFLGTSISPLRKLNKSLFSTLYTKLVPSSSSSSASACSVSEKYSTPKLSRSVAEYYSLRKENSVHFNSPTPKGKRSRKDSNVRFTNFLLSDIEKLDPNVEDLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJR4</accession>
    <name>Q6FJR4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M04213g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449530.1">
        <property type="nucleotide sequence ID" value="XM_449530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJR4"/>
    <dbReference type="FunCoup" id="Q6FJR4">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJR4"/>
    <dbReference type="MEROPS" id="C26.A05"/>
    <dbReference type="KEGG" id="cgr:2891539"/>
    <dbReference type="CGD" id="CAL0136523">
        <property type="gene designation" value="CAGL0M04213g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04213g"/>
    <dbReference type="eggNOG" id="KOG3179">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054974_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FJR4"/>
    <dbReference type="OMA" id="PWIQTLK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="100"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="255" mass="28817" checksum="E1568E54A9786934" modified="2004-07-19" version="1">MTVAARKVAIFYTDHPNEWSRDDGTFATMAVELLEQAKEHEPYVGAEGGIEYRVFDVYNGELPSVDELSSGDYLGLYITGSRYDSFDTETQWIVDLRKLLYRLVNETTLPIVGICFGHQVLARSLGAQVGRNPKGLEAGVHGVQLNATGKTLFSRDRLYLSELHSDHVEEVPPGYENWGHTEKSHCQGLYKPQRVLTFQGHPEFTTQLAIKSTQHKHQTGQLSDEEYAETIQRCHSNNDGVHAARNIWKLYHGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJS3</accession>
    <name>Q6FJS3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein DAL82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M04015g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJS3"/>
    <dbReference type="FunCoup" id="Q6FJS3">
        <property type="interactions" value="625"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJS3"/>
    <dbReference type="KEGG" id="cgr:2891530"/>
    <dbReference type="CGD" id="CAL0136587">
        <property type="gene designation" value="CAGL0M04015g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04015g"/>
    <dbReference type="eggNOG" id="ENOG502S89R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1008314_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJS3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31271" checksum="D9C46E31763786AB" modified="2004-07-19" version="1">MRVESQQSAIVLLELMDKYKPHLKPYAYRLHSWERVLADYNSRLHTKYRQIRTIKNKFERLKYMYLQDRGSEQFKGYSEAELVLLERLISESDGVSVKDPIVRDNGMSQGALASGGRPPEPALVPRLPMLGGQLLKQSTINNIIEPTPPPLDTISIGMPKNAKKPSIQDTGLAGQPTMEDSTVTAGTPLDTSIFDGDTRIPTRKNSLDVHTIQDLVRKLSDQQKQEDQLMIMKEAELSKKYMTQADFLSYKKQNRAIQLQILNVITSLLETPTKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJY7</accession>
    <name>Q6FJY7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M02541g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449457.1">
        <property type="nucleotide sequence ID" value="XM_449457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJY7"/>
    <dbReference type="KEGG" id="cgr:2891465"/>
    <dbReference type="CGD" id="CAL0136445">
        <property type="gene designation" value="CAGL0M02541g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02541g"/>
    <dbReference type="HOGENOM" id="CLU_3242076_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJY7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0136445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="43" mass="4870" checksum="D2F9DEF8320FDA55" modified="2004-07-19" version="1">MLGAPISRDTPRKTRSKTQFFQGPIVSLITEKCTYEWGNPSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK16</accession>
    <name>Q6FK16_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M01914g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449428.1">
        <property type="nucleotide sequence ID" value="XM_449428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK16"/>
    <dbReference type="STRING" id="284593.Q6FK16"/>
    <dbReference type="KEGG" id="cgr:2891754"/>
    <dbReference type="CGD" id="CAL0137097">
        <property type="gene designation" value="CAGL0M01914g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01914g"/>
    <dbReference type="eggNOG" id="ENOG502S2KG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_406515_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK16"/>
    <dbReference type="OMA" id="YHRFACY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="676" mass="76946" checksum="DFC2DA9CC9A62A79" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK72</accession>
    <name>Q6FK72_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0M00616g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK72"/>
    <dbReference type="FunCoup" id="Q6FK72">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK72"/>
    <dbReference type="KEGG" id="cgr:2891595"/>
    <dbReference type="CGD" id="CAL0137293">
        <property type="gene designation" value="CAGL0M00616g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00616g"/>
    <dbReference type="eggNOG" id="KOG2195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005688_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FK72"/>
    <dbReference type="OMA" id="QGSTEWV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03874">
        <property type="entry name" value="M28_PMSA_TfR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="384"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="4">
        <location>
            <begin position="690"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0137293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="772" mass="88102" checksum="DF492F5B673361B3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK88</accession>
    <name>Q6FK88_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2C-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M00264g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK88"/>
    <dbReference type="FunCoup" id="Q6FK88">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK88"/>
    <dbReference type="KEGG" id="cgr:2891147"/>
    <dbReference type="CGD" id="CAL0136637">
        <property type="gene designation" value="CAGL0M00264g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00264g"/>
    <dbReference type="eggNOG" id="KOG4784">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029122_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK88"/>
    <dbReference type="OMA" id="QAMKVFY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0136637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="41180" checksum="755660BBBBDBC8BF" modified="2004-07-19" version="1">MKYLVEELENVGVTLIAVEALNNVSYSISTNRSTLELRVINDSYKTSIRLKGLNLDNLYDEKNGHIHLSETSCGYVRLKRKTQALTNRISLVDLPDDKWNIERFKKMQGFQIACNNCKLVVLDSEVNIKKISEMPSEFWAEFMDYWHCHKPTIGESKTDAKPYDYYKELKPRLNEVLVGNTYFQTIGSTIDRKVVVQTDGSVDCSNCRSTLGYKEGSEILVLEKQNLQLQDTFKELSEDYPGYLVVLARILSLLKFNSTRYFALKTGGQKPIFIWVLAYDCSVAYTGNELVQRAYKLLYKDSWDRPPSSMEDIQLSDDLLDSFLQQLTKIHELIPENLKMFNGWKVSYMSIEDTNPI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKB1</accession>
    <name>SET1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="1">2.1.1.354</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>COMPASS component SET1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SET1</name>
        <name type="ordered locus">CAGL0L12980g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The RxxxRR motif forms an adapter helix that bridges the nucleosome and ubiquitin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class V-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="1"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449333.1">
        <property type="nucleotide sequence ID" value="XM_449333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKB1"/>
    <dbReference type="SMR" id="Q6FKB1"/>
    <dbReference type="FunCoup" id="Q6FKB1">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKB1"/>
    <dbReference type="EnsemblFungi" id="CAGL0L12980g-T">
        <property type="protein sequence ID" value="CAGL0L12980g-T-p1"/>
        <property type="gene ID" value="CAGL0L12980g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890583"/>
    <dbReference type="KEGG" id="cgr:2890583"/>
    <dbReference type="CGD" id="CAL0135102">
        <property type="gene designation" value="SET1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12980g"/>
    <dbReference type="eggNOG" id="KOG1080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004391_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKB1"/>
    <dbReference type="OMA" id="ERLPCLC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905088">
        <property type="term" value="P:positive regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903341">
        <property type="term" value="P:regulation of meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055092">
        <property type="term" value="P:sterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12302">
        <property type="entry name" value="RRM_scSet1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000056">
        <property type="entry name" value="Histone-lysine N-methyltransferase, H3 lysine-4 specific"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048669">
        <property type="entry name" value="SET1_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21569">
        <property type="entry name" value="SET1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000269768" description="Histone-lysine N-methyltransferase, H3 lysine-4 specific">
        <location>
            <begin position="1"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="969"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="648"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="891"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RxxxRR motif" evidence="1">
        <location>
            <begin position="935"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="897"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="1085"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="1111" mass="127906" checksum="79C2294F8540340F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKC4</accession>
    <name>Q6FKC4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0L12694g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKC4"/>
    <dbReference type="FunCoup" id="Q6FKC4">
        <property type="interactions" value="1135"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKC4"/>
    <dbReference type="KEGG" id="cgr:2890606"/>
    <dbReference type="CGD" id="CAL0135978">
        <property type="gene designation" value="CAGL0L12694g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12694g"/>
    <dbReference type="eggNOG" id="KOG2280">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008909_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKC4"/>
    <dbReference type="OMA" id="YVTFWYP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035542">
        <property type="term" value="P:regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099022">
        <property type="term" value="P:vesicle tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="488"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0135978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="806" mass="93025" checksum="A76C73F5C3EFF8F4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKC8</accession>
    <name>Q6FKC8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAGL0L12606g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKC8"/>
    <dbReference type="FunCoup" id="Q6FKC8">
        <property type="interactions" value="789"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKC8"/>
    <dbReference type="KEGG" id="cgr:2890602"/>
    <dbReference type="eggNOG" id="KOG0433">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_7_2_1"/>
    <dbReference type="InParanoid" id="Q6FKC8"/>
    <dbReference type="OMA" id="PVYWGTE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000029">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.830">
        <property type="entry name" value="Ile-tRNA synthetase CP2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="10">
        <location>
            <begin position="72"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="11">
        <location>
            <begin position="744"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG62290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="982" mass="112207" checksum="E9969CB013A2FD90" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKF7</accession>
    <name>Q6FKF7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0L11946g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FKF7">
        <property type="interactions" value="1416"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKF7"/>
    <dbReference type="KEGG" id="cgr:2890951"/>
    <dbReference type="CGD" id="CAL0136200">
        <property type="gene designation" value="CAGL0L11946g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11946g"/>
    <dbReference type="eggNOG" id="KOG0951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKF7"/>
    <dbReference type="OMA" id="WISCETE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="497"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="714"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1346"/>
            <end position="1522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="2140" mass="242611" checksum="925BF36BABF9237A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKJ9</accession>
    <name>CAF20_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Cap-associated protein CAF20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CAF20</name>
        <name type="ordered locus">CAGL0L10978g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CAF20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449245.1">
        <property type="nucleotide sequence ID" value="XM_449245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKJ9"/>
    <dbReference type="SMR" id="Q6FKJ9"/>
    <dbReference type="FunCoup" id="Q6FKJ9">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKJ9"/>
    <dbReference type="EnsemblFungi" id="CAGL0L10978g-T">
        <property type="protein sequence ID" value="CAGL0L10978g-T-p1"/>
        <property type="gene ID" value="CAGL0L10978g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891020"/>
    <dbReference type="KEGG" id="cgr:2891020"/>
    <dbReference type="CGD" id="CAL0135778">
        <property type="gene designation" value="CAGL0L10978g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L10978g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10978g"/>
    <dbReference type="eggNOG" id="ENOG502S2E7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128343_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKJ9"/>
    <dbReference type="OMA" id="GRPKVKH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010606">
        <property type="term" value="P:positive regulation of cytoplasmic mRNA processing body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031456">
        <property type="entry name" value="Caf20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17052">
        <property type="entry name" value="CAF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000330085" description="Cap-associated protein CAF20">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="154" mass="17274" checksum="199C5821ADBAE764" modified="2004-07-19" version="1">MIKYSIDELIQLKPSETLKVSFDHVEFRNIIEKVVELQKLKEEEFHSHHGNRRRSSHHHMKPKIKHNKPKVKTDADGWSTLEPATAGHEEESSSSATPAAAATTKTGAPQETIRVKPNNKNISSSRPADNSDIIADKQTHGFNAFAALEDEEDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKN6</accession>
    <name>XRN2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>5'-3' exoribonuclease 2</fullName>
            <ecNumber>3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RAT1</name>
        <name type="ordered locus">CAGL0L10120g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Possesses 5'-&gt;3' exoribonuclease activity (By similarity). Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II (By similarity). Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity (By similarity). The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449208.1">
        <property type="nucleotide sequence ID" value="XM_449208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKN6"/>
    <dbReference type="SMR" id="Q6FKN6"/>
    <dbReference type="FunCoup" id="Q6FKN6">
        <property type="interactions" value="1172"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKN6"/>
    <dbReference type="EnsemblFungi" id="CAGL0L10120g-T">
        <property type="protein sequence ID" value="CAGL0L10120g-T-p1"/>
        <property type="gene ID" value="CAGL0L10120g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891058"/>
    <dbReference type="KEGG" id="cgr:2891058"/>
    <dbReference type="CGD" id="CAL0135840">
        <property type="gene designation" value="CAGL0L10120g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L10120g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10120g"/>
    <dbReference type="eggNOG" id="KOG2044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006038_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FKN6"/>
    <dbReference type="OMA" id="ITHDMVV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110103">
        <property type="term" value="C:RNA polymerase II termination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904595">
        <property type="term" value="P:positive regulation of termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043144">
        <property type="term" value="P:sno(s)RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030846">
        <property type="term" value="P:termination of RNA polymerase II transcription, poly(A)-coupled"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0806">Transcription termination</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000249921" description="5'-3' exoribonuclease 2">
        <location>
            <begin position="2"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="939"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="468"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="948"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P40848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q02792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1018" mass="117656" checksum="ED5034F0A90B5912" modified="2007-01-23" version="3"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKP7</accession>
    <name>Q6FKP7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0L09779g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKP7"/>
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        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891080"/>
    <dbReference type="CGD" id="CAL0135560">
        <property type="gene designation" value="CAGL0L09779g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09779g"/>
    <dbReference type="eggNOG" id="ENOG502SA6M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151392_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKP7"/>
    <dbReference type="OMA" id="WGEYLFD"/>
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        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013726">
        <property type="entry name" value="Mitofissin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28075:SF1">
        <property type="entry name" value="DUF1748-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08520">
        <property type="entry name" value="Mitofissin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0135560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="82" mass="9511" checksum="28ACFEC2592498B7" modified="2004-07-19" version="1">MSVGSIVRWGVDLTLVAIVLASLRRSTGLVLRYETMGFSGWIHGYLQWGEMCFGYLKSYVKRSPWFRPQVTYDGFKKIEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKT5</accession>
    <name>Q6FKT5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome quality control complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0L08822g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKT5"/>
    <dbReference type="FunCoup" id="Q6FKT5">
        <property type="interactions" value="1065"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKT5"/>
    <dbReference type="KEGG" id="cgr:2891090"/>
    <dbReference type="CGD" id="CAL0135210">
        <property type="gene designation" value="CAGL0L08822g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08822g"/>
    <dbReference type="eggNOG" id="KOG2030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003612_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FKT5"/>
    <dbReference type="OMA" id="MFLEFFA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904678">
        <property type="term" value="F:alpha-aminoacyl-tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140708">
        <property type="term" value="P:CAT tailing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043043">
        <property type="term" value="P:peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.310.10:FF:000003">
        <property type="entry name" value="Zinc knuckle domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="8">
        <location>
            <begin position="586"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="9">
        <location>
            <begin position="908"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="720"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="825"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="864"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="340"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="762"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="825"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="864"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1012"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0135210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1031" mass="118459" checksum="3032E00F1F698F01" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKX8</accession>
    <name>Q6FKX8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0L07788g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKX8"/>
    <dbReference type="FunCoup" id="Q6FKX8">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKX8"/>
    <dbReference type="KEGG" id="cgr:2891005"/>
    <dbReference type="CGD" id="CAL0135110">
        <property type="gene designation" value="CAGL0L07788g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07788g"/>
    <dbReference type="eggNOG" id="KOG3771">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072096_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKX8"/>
    <dbReference type="OMA" id="TRFCAYF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060988">
        <property type="term" value="P:lipid tube assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07591">
        <property type="entry name" value="BAR_Rvs161p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000014">
        <property type="entry name" value="Protein hob3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037429">
        <property type="entry name" value="Rvs161/Hob3_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="5">
        <location>
            <begin position="15"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0135110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="265" mass="30436" checksum="482E345561658D54" modified="2004-07-19" version="1">MSWEGFKKAINRAGNSVIIKNVDKTIDKEYDMEERRFRVLQKAGESLQKEAKGYLDSLRAVTASQVTIAEVISNLYDDSKYISGGGYNVGNYYLQCVQDFDTETVKQLDGPFRETVLDPVTKFATYFKEIDEAIKKREHKKKDYDAAKAKVRRMIDKPAKDASKLPRAEKEMALAKDIYENLNNQLKTELPQLVSLRVPYFDPSFEALVKIQLRFCTDGYTRLAQIQQYLDQQSRDDYANGLLDDKIEELLHQMMGLDICALGLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL25</accession>
    <name>RT09_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit protein uS9m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>37S ribosomal protein S9, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MRPS9</name>
        <name type="ordered locus">CAGL0L06732g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449069.1">
        <property type="nucleotide sequence ID" value="XM_449069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL25"/>
    <dbReference type="SMR" id="Q6FL25"/>
    <dbReference type="FunCoup" id="Q6FL25">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL25"/>
    <dbReference type="EnsemblFungi" id="CAGL0L06732g-T">
        <property type="protein sequence ID" value="CAGL0L06732g-T-p1"/>
        <property type="gene ID" value="CAGL0L06732g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890668"/>
    <dbReference type="KEGG" id="cgr:2890668"/>
    <dbReference type="CGD" id="CAL0136082">
        <property type="gene designation" value="CAGL0L06732g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06732g"/>
    <dbReference type="eggNOG" id="KOG1697">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036531_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL25"/>
    <dbReference type="OMA" id="RESAMWA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000001">
        <property type="entry name" value="30S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_uS9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001099">
        <property type="entry name" value="PRK00132.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="1">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000030646" description="Small ribosomal subunit protein uS9m">
        <location>
            <begin status="unknown"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="288" mass="32961" checksum="AD4D8B18FF4E303D" modified="2004-07-19" version="1" precursor="true">MWMRVNRMLGNVSVRQFSNVRLVAQEYSMRVQQARNRIVPKSLTFYSANPLHEEKISRLESLLKKYALPSSQKLPGADISAEENLKQNPRPSWISFSDYALIGGGTRLKPRHYEHFIQLLNKLNNIDPQLVNTEIKNELSKYIKKSSIQSQKTQQKELDEFGRSVAIGKRKAATAKVYLVRGEGKILVNGRQLNDYFLKMKDRESIAYPLQVVDSLGKYNVFATCRGGGPTGQAEAIMHAIAKALLVFNPLLKPRLRKAGVITRDYRHVERKKPGKKKARKMPTWVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLH0</accession>
    <name>Q6FLH0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0L03476g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG61894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="cgr:2890735"/>
    <dbReference type="CGD" id="CAL0135252">
        <property type="gene designation" value="CAGL0L03476g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03476g"/>
    <dbReference type="eggNOG" id="KOG1418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013394_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FLH0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="231"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="365"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="756"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="756"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0135252"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG61894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="796" mass="89301" checksum="7D24DEE975884D64" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLR9</accession>
    <name>Q6FLR9_CANGA</name>
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        <recommendedName>
            <fullName evidence="5">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6 7" type="ordered locus">CAGL0L01199g</name>
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    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAG61795.1"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG4137">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071116_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FLR9"/>
    <dbReference type="OMA" id="LPTHMKF"/>
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        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="5">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0135322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="132" mass="15074" checksum="A58C0846E1DC94AC" modified="2004-07-19" version="1">MEVDRIEVLKEVFAQNVQAASLGFKRQHQKRVGKGRHKSCKQLLSDEQKRINNECLNNGKVPKVTYFNVEAPPSLKPAKKYCDITGLKANYRSPTNNIRYHNAEIYQLVVKPMAAGVDQEYLKLRGANFVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLY5</accession>
    <name>Q6FLY5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K12496g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLY5"/>
    <dbReference type="FunCoup" id="Q6FLY5">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLY5"/>
    <dbReference type="KEGG" id="cgr:2889988"/>
    <dbReference type="CGD" id="CAL0133913">
        <property type="gene designation" value="CAGL0K12496g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12496g"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q6FLY5"/>
    <dbReference type="OMA" id="SIDITHC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097472">
        <property type="term" value="F:cyclin-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060633">
        <property type="term" value="P:negative regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="360" mass="41450" checksum="433A2953762D2598" modified="2004-07-19" version="1">MNSPRQLITHTKIASIYRVKDLAVKIVSTEHHIPPHNVQRERRILRKLAVEPVNQGYGAHVIKLIEDQCKNSNIELWFKFYPIDLEDYLRSCFKPQNKFNPYYTLGEVLETSLRSSYVNEFDVNEFAKDFFLQIVKGLNFIHQSGIIHRDIKPRNIVLEKLSTGKFNLVLIDFGISYDITETNIDERPDSKITDVSTSIYKAPELLFGVKNYSSAVDIWAMLVILSNFFSLASDCKNYLSSCFDDGYRPGEEDGSDIKLIFSIFEKFGVPTANEWPEVINHGSSEVFNGFFGNSDTSRYIMKLSAVEQRQIIASTFPRIEELSDTKFKNKLYEILVKMASYESTCRITALEILQLLENNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM44</accession>
    <name>Q6FM44_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0K11132g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM44"/>
    <dbReference type="FunCoup" id="Q6FM44">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM44"/>
    <dbReference type="KEGG" id="cgr:2890088"/>
    <dbReference type="CGD" id="CAL0133985">
        <property type="gene designation" value="CAGL0K11132g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11132g"/>
    <dbReference type="eggNOG" id="ENOG502R3P5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_554561_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM44"/>
    <dbReference type="OMA" id="WKNLDRI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043954">
        <property type="entry name" value="Snu56_snRNP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19097">
        <property type="entry name" value="Snu56_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="477" mass="54126" checksum="6A5183768E5E81E7" modified="2004-07-19" version="1">MMRKRARNGYDGDRENRSALNKKAKRHPALTQDSYDLWKNLDRIRKLHKNSDKVLKRSVVLIPLSCETNNTIVQCIQHLLRYVDQERLHFKTVSGQLYTHVVILRNFSVLDFCLVVPVLLSAVKRLNSKTSDYFKFDSHIFCNGTFFVPDNTVISIDRTTLQLKETALRLIPGFKELNCTPTESNNIQDMINTLANFISKVKFGKNKDDIYATFKRELALFSKRTRFGLGEVSMLEKGMLIDSQAVIDKNLPLVQNTKAKLQTYVQTLLDENEDKITTEVQTTAAKSSDAISSTNGNNNVASKPIQSRFQNNQSHNVPSSRYSHQATSTAIRKPYTAKEASPLPTQSRASPGRPRFMTIEEIRGRCIATVRASIDSVKKISAYQIVKVYVKFPKKDSDTLFSNLDELRNKSNCNIVVLHYNNEHESKQWLDGLDLTRYIRGQDEPNASTVRILSIGGVAEYIVTALEGILALLQEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM59</accession>
    <name>Q6FM59_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="14">IMP dehydrogenase</shortName>
            <shortName evidence="14">IMPD</shortName>
            <shortName evidence="14">IMPDH</shortName>
            <ecNumber evidence="14 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22 23" type="ordered locus">CAGL0K10780g</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="14 20"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM59"/>
    <dbReference type="FunCoup" id="Q6FM59">
        <property type="interactions" value="1355"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM59"/>
    <dbReference type="KEGG" id="cgr:2890108"/>
    <dbReference type="CGD" id="CAL0133879">
        <property type="gene designation" value="CAGL0K10780g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10780g"/>
    <dbReference type="eggNOG" id="KOG2550">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FM59"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
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</entry>
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    <accession>Q6FM71</accession>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
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                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
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                <person name="Swennene D."/>
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                <person name="Zeniou-Meyer M."/>
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                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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    <sequence length="186" mass="21569" checksum="3E1E05C4FD9409CF" modified="2004-07-19" version="1">MSQLEQASVTMNSSLEFINMQNPPPPKDSPYLAYIDKGCGESPTNIKSVPYPTRRRSTNYVNTLRDKGLLREMEEVRTDVDKVSSKGDNNYTYGNLTSMSQQDMKHESSKYFMAGSSHIPPQFDKLVYMGDSIDYDGPRRQYMEAEDAMDPLYKGYNGKVYKRRPSFQYEDFKKDVYDKLHIFNDN</sequence>
</entry>
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    <accession>Q6FMA2</accession>
    <name>Q6FMA2_CANGA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2 3" type="ordered locus">CAGL0K09746g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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        <name type="synonym">Nakaseomyces glabratus</name>
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            <taxon>Saccharomycetales</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
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                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
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                <person name="Beyne E."/>
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                <person name="de Daruvar A."/>
                <person name="Despons L."/>
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                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
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                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
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                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMA2"/>
    <dbReference type="STRING" id="284593.Q6FMA2"/>
    <dbReference type="KEGG" id="cgr:2890198"/>
    <dbReference type="CGD" id="CAL0134963">
        <property type="gene designation" value="CAGL0K09746g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09746g"/>
    <dbReference type="eggNOG" id="KOG4051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333163_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMA2"/>
    <dbReference type="OMA" id="RFKKPYD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043189">
        <property type="term" value="C:H4/H2A histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012423">
        <property type="entry name" value="Eaf7/MRGBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07904">
        <property type="entry name" value="Eaf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
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        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
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            <begin position="257"/>
            <end position="279"/>
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            <end position="315"/>
        </location>
    </feature>
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        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
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        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="417"/>
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    </feature>
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        <location>
            <begin position="440"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
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        <location>
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            <end position="686"/>
        </location>
    </feature>
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        <location>
            <begin position="716"/>
            <end position="758"/>
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            <end position="783"/>
        </location>
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        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="858" mass="95349" checksum="CCC5D6E1E1BCBBF6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMF6</accession>
    <name>Q6FMF6_CANGA</name>
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        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0K08426g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMP24/GP25L family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG61551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FMF6">
        <property type="interactions" value="1007"/>
    </dbReference>
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    <dbReference type="KEGG" id="cgr:2890314"/>
    <dbReference type="CGD" id="CAL0134321">
        <property type="gene designation" value="CAGL0K08426g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08426g"/>
    <dbReference type="eggNOG" id="KOG1692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FMF6"/>
    <dbReference type="OMA" id="MQVRDRN"/>
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        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="57"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0134321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="230" mass="26146" checksum="A48411295454B380" modified="2004-07-19" version="1">MGNRIEKELRVVGGEDIVRFYSHSISYNKGKMLFGILVALFLSVVSAHNVLLPPHGRRCFTEKLGKGDELSITFQFGDRDPESSHQLTGDFTLTGVDSNTLHKTLRDVSHGDVVFSAPHSGNFEYCFSNENSNIKTKDVTFNMHGIVYVDLDDPNANTLDSAVRKLAKLTNEVKDEQSYIVIRERTHRNTAESTNDRVKWWSIFQLGLVVANSLFQIYYLKRFFEVTSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMG8</accession>
    <name>Q6FMG8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0K08162g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMG8"/>
    <dbReference type="FunCoup" id="Q6FMG8">
        <property type="interactions" value="2085"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMG8"/>
    <dbReference type="KEGG" id="cgr:2890344"/>
    <dbReference type="CGD" id="CAL0134261">
        <property type="gene designation" value="CAGL0K08162g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08162g"/>
    <dbReference type="eggNOG" id="ENOG502QQ2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007860_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FMG8"/>
    <dbReference type="OMA" id="RSRQTCF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090207">
        <property type="term" value="P:regulation of triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="3">
        <location>
            <begin position="62"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0134261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="716" mass="81257" checksum="AC0730C5F9B60DF7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMJ3</accession>
    <name>MYO3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Myosin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Class I unconventional myosin MYO3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Type I myosin MYO3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MYO3</name>
        <name type="ordered locus">CAGL0K07590g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The tail domain participates in molecular interactions that specify the role of the motor domain (By similarity). It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylation of the TEDS site (Ser-357) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448551.1">
        <property type="nucleotide sequence ID" value="XM_448551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMJ3"/>
    <dbReference type="SMR" id="Q6FMJ3"/>
    <dbReference type="STRING" id="284593.Q6FMJ3"/>
    <dbReference type="EnsemblFungi" id="CAGL0K07590g-T">
        <property type="protein sequence ID" value="CAGL0K07590g-T-p1"/>
        <property type="gene ID" value="CAGL0K07590g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890383"/>
    <dbReference type="KEGG" id="cgr:2890383"/>
    <dbReference type="CGD" id="CAL0134555">
        <property type="gene designation" value="MYO3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K07590g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07590g"/>
    <dbReference type="eggNOG" id="KOG0162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000192_7_6_1"/>
    <dbReference type="InParanoid" id="Q6FMJ3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007121">
        <property type="term" value="P:bipolar cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01378">
        <property type="entry name" value="MYSc_Myo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11858">
        <property type="entry name" value="SH3_Myosin-I_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000015">
        <property type="entry name" value="Myosin I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4820:FF:000004">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000007">
        <property type="entry name" value="Myosin IE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035535">
        <property type="entry name" value="Fungal_myosin-I_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010926">
        <property type="entry name" value="Myosin_TH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036072">
        <property type="entry name" value="MYSc_Myo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF837">
        <property type="entry name" value="MYOSIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06017">
        <property type="entry name" value="Myosin_TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51757">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0505">Motor protein</keyword>
    <keyword id="KW-0518">Myosin</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0728">SH3 domain</keyword>
    <feature type="chain" id="PRO_0000338544" description="Myosin-3">
        <location>
            <begin position="1"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="4">
        <location>
            <begin position="36"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="IQ 1">
        <location>
            <begin position="719"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="IQ 2">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="TH1" evidence="5">
        <location>
            <begin position="773"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="3">
        <location>
            <begin position="1116"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="1">
        <location>
            <begin position="404"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="988"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1106"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1203"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="997"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1050"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1106"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1203"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1238"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="129"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="1252" mass="141600" checksum="EBEB17C7DDBFEBBA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMT3</accession>
    <name>Q6FMT3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Type 2A phosphatase activator TIP41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0K05423g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMT3"/>
    <dbReference type="FunCoup" id="Q6FMT3">
        <property type="interactions" value="859"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMT3"/>
    <dbReference type="KEGG" id="cgr:2890485"/>
    <dbReference type="CGD" id="CAL0134073">
        <property type="gene designation" value="CAGL0K05423g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05423g"/>
    <dbReference type="eggNOG" id="KOG3224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039187_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FMT3"/>
    <dbReference type="OMA" id="DMILFED"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0134073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="46423" checksum="5AD420DAB14D9509" modified="2004-07-19" version="1">MSASDPSLPNGAKKPNRPGAERGPGINAIQINAAREMHAMSIRGRNPRNANTTSGSSILTRTTIPVEASHTSTFATPSAPDTTINKSPKKKNDIPHHVCNNNPNNPNCPHCGTVIIPSPRATLPLKDSPSITVADTWKVTTQKRPILNSQELDDWEANKLQKLPLPEMIFGNNFVRIDNVKNGWYIEFNALDALRQVNLEDTGLRVAHSKVWMQSKQKQQQQQQQQQQQQQEKTSSSESSSANPLEIAHPYDWTYTTLYKGTTPTDAKLPKFEEDIGAELPIDKLSRPDKILFFDDMILFEDELADNGISVLNVKIRVMHERLLLLSRFFLRVDDVLVRVIDTRVYVDFTDNIVIREFKKHECHYNELLAKHQRSNKKTLHDPKAALRDSNWVVEHTPLIERKAEIIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN28</accession>
    <name>Q6FN28_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mmc1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0K03245g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448366.1">
        <property type="nucleotide sequence ID" value="XM_448366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN28"/>
    <dbReference type="KEGG" id="cgr:2890166"/>
    <dbReference type="CGD" id="CAL0134021">
        <property type="gene designation" value="CAGL0K03245g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03245g"/>
    <dbReference type="eggNOG" id="ENOG502RY8K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_586688_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN28"/>
    <dbReference type="OMA" id="AFVYYQL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Mmc1 C-terminal" evidence="2">
        <location>
            <begin position="352"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0134021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="476" mass="54918" checksum="4B8474B2A6C88C22" modified="2004-07-19" version="1">MLLFGSARRCVHGWSHVAKQLGKYGVDEVAISKLRLLQENTAIRCGVLMNTRQGSFGSAFVTDKEALGSSWVPTLINRWVNEDKTPVLMKYGDQFREINGEVRTFEIPSSFLKETNAEILEIPEQDQSKDKRLPHVHDGCHVYLDIRGDPTVSQPTWPTIEIEDVLSKGKLLLTNQIDSQMALESLLKYNNSTISEYLNKQNASNFDRIRAKLVDKLKDGNLIRTELKSSIRRYLQSTDRDISNEKRLIGKRDLTNEEIDKWAECSHKTLRDEIVPSFLSFARAHLSLWKLYTYSPAKLKLNFMEYCMIPLYKVHEIENSAKVLEANMFREFDLETVSAQVMTPILPTTEIQKIGRIQTEINKAIYKQFFTIQLPMVLCALLGVVSEQFSAYYMGSLAALGIVLGFWRCMKQWQYILNGYTRKVAFLLKDRIELRRAELKKLSDRCFEEKALAAKKKKELLEPLLEVDLRQKNKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNM8</accession>
    <name>Q6FNM8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0J10450g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448166.1">
        <property type="nucleotide sequence ID" value="XM_448166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNM8"/>
    <dbReference type="STRING" id="284593.Q6FNM8"/>
    <dbReference type="KEGG" id="cgr:2889604"/>
    <dbReference type="CGD" id="CAL0132878">
        <property type="gene designation" value="CAGL0J10450g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10450g"/>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014001_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FNM8"/>
    <dbReference type="OMA" id="FQYYPQY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000011">
        <property type="entry name" value="SEC14 cytosolic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="102"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="306" mass="34934" checksum="DE413D155C6BEB4B" modified="2004-07-19" version="1">MSEEAIKKEKEILDSFPSVCEPGSPSGTPGNLNDSQKKALAQLKEQLQKDGYKLRLDDATLLRFLRARKFNVAMAKEMYVACEKWRKSAGVDTILEDFHYEEKPLVAKYYPQYYHKIDKDGRPVYFEELGTVNLNEMYKITTHERMIKNLVWEYESFVKYRLPACSRSRGYLIETSCTIMDLKGISISSAYHVLSYVKEASHIGQNYYPERMGKFYLINAPFGFSTAFRLFKPFLDPVTVSKIFILGSSYKKELLKQIPAENLPVKYGGKSEVSSSKGGLALSDIGPWRDPKFIGPEGEAPKSFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNN3</accession>
    <name>Q6FNN3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nucleoporin SEH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0J10340g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNN3"/>
    <dbReference type="FunCoup" id="Q6FNN3">
        <property type="interactions" value="1297"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNN3"/>
    <dbReference type="KEGG" id="cgr:2889599"/>
    <dbReference type="CGD" id="CAL0133134">
        <property type="gene designation" value="CAGL0J10340g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10340g"/>
    <dbReference type="eggNOG" id="KOG2445">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032441_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FNN3"/>
    <dbReference type="OMA" id="NAPTRRW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000578">
        <property type="entry name" value="Nucleoporin seh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF3">
        <property type="entry name" value="NUCLEOPORIN SEH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0133134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG61112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38283" checksum="4FAABCC3078A4FF4" modified="2004-07-19" version="1">MQPFNTGHEDIVHDVAYDFYGRTMATCSSDQHIKVFKLDKDATRWEVNDSWRAHDSSIVSLDWASPEYGRIIASASYDKTIKIWEEDPNQEECSGRRWTRLCTLNDSKGSLYCVKFAPSHLGLRIASIGNDGIMRMYDALDPSNLRSWTMTAEVKVLPVAPANNLQSAFGLSWCFTRFSPEKIAVCALDQAYIYQRGKDGHFYQAGKLPGHTSLIRSISWAPLIGRPYHLIATGCKDGRVRIFRVNDSPSKSNTPNLSDSDDYNMEDQGIKQRQNNTDLEVELLSEHDDHKGEVWSVSWNLTGTILSSTGEDGKVRLWKSTYSNEYKCMSIITSKQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNT7</accession>
    <name>Q6FNT7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho GDP-dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J09152g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rho GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNT7"/>
    <dbReference type="FunCoup" id="Q6FNT7">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNT7"/>
    <dbReference type="KEGG" id="cgr:2889945"/>
    <dbReference type="CGD" id="CAL0133734">
        <property type="gene designation" value="CAGL0J09152g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09152g"/>
    <dbReference type="eggNOG" id="KOG3205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076228_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FNT7"/>
    <dbReference type="OMA" id="YKPTAAK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005094">
        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.50.30:FF:000001">
        <property type="entry name" value="Rho GDP-dissociation inhibitor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.30">
        <property type="entry name" value="Coagulation Factor XIII, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000406">
        <property type="entry name" value="Rho_GDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024792">
        <property type="entry name" value="RhoGDI_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980:SF3">
        <property type="entry name" value="LD16419P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10980">
        <property type="entry name" value="RHO GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02115">
        <property type="entry name" value="Rho_GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00492">
        <property type="entry name" value="RHOGDI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0133734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="200" mass="22975" checksum="B5440B9AB02958EB" modified="2004-07-19" version="1">MSEPDFNDFEESTNDDKYKVSEKKTVDEYKKLDAEDESLAKWKESLGLSSDVLPLEFPGDTRKVVIQKIQLLVDTEKEPITFDLTNETTIKELASKRYKVKEKSIYKLRITFKVQHEIITGLRYVQYIKKAGIAVDKIDDHLGSYAPNTKQKPFYEVELPESEAPSGFLARGNYSAVSKFIDDDKTTHLTLNWGVEIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNV6</accession>
    <name>Q6FNV6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PMT2</name>
        <name evidence="18 19" type="ordered locus">CAGL0J08734g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448088.1">
        <property type="nucleotide sequence ID" value="XM_448088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNV6"/>
    <dbReference type="FunCoup" id="Q6FNV6">
        <property type="interactions" value="985"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNV6"/>
    <dbReference type="CAZy" id="GT39">
        <property type="family name" value="Glycosyltransferase Family 39"/>
    </dbReference>
    <dbReference type="GeneID" id="2889674"/>
    <dbReference type="KEGG" id="cgr:2889674"/>
    <dbReference type="CGD" id="CAL0133244">
        <property type="gene designation" value="PMT2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08734g"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FNV6"/>
    <dbReference type="OMA" id="MCGWDDN"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="661"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="328"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="395"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="459"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0133244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG61039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="742" mass="84788" checksum="B1862874B8E9B2B4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNZ6</accession>
    <name>Q6FNZ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0J07832g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNZ6"/>
    <dbReference type="FunCoup" id="Q6FNZ6">
        <property type="interactions" value="512"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNZ6"/>
    <dbReference type="KEGG" id="cgr:2889908"/>
    <dbReference type="CGD" id="CAL0133618">
        <property type="gene designation" value="CAGL0J07832g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07832g"/>
    <dbReference type="eggNOG" id="KOG4548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040204_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNZ6"/>
    <dbReference type="OMA" id="HPFENAF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="9">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0133618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="265" mass="30249" checksum="450A0695CBE9E5AD" modified="2004-07-19" version="1">MLSVRGLATAAKATGSPAVKVGLILSRVPLVSPEKSELESSYYKYMSELERRLMWTFPAYFYFKKGTLSEHRFYAAQKGPISKQEGVWFPKGVPDIKHGRERSQKQTINLPKSKQQEGQASDDISRPIIANSIVTEADKNNDLTSLERSLRRTLYLLIKDKKGIWKFPNFDIGEEKSLHRAAEKGIREIGGENMNTWTVSRTPAAVLKDDPKSSQFLIKSHILMGRFDIQDKRILSDFAWLSKDEIKGKVEKNYYEKISFLLSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP08</accession>
    <name>Q6FP08_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="2 10">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0J07568g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="8">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2 10"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP08"/>
    <dbReference type="FunCoup" id="Q6FP08">
        <property type="interactions" value="746"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP08"/>
    <dbReference type="MEROPS" id="C01.085"/>
    <dbReference type="KEGG" id="cgr:2889896"/>
    <dbReference type="CGD" id="CAL0129659">
        <property type="gene designation" value="CAGL0J07568g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07568g"/>
    <dbReference type="eggNOG" id="KOG4128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038600_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FP08"/>
    <dbReference type="OMA" id="DDGGWWQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000091">
        <property type="entry name" value="Aminopeptidase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="11">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0129659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="466" mass="54061" checksum="1FFCD4A82770CDE3" modified="2004-07-19" version="1">MYRLRSLIRPIRKYSMSRSLAIDEIASWDKELSKDLHHQLATTVLKNINADDALLNKTRLQEQDVRVFNTKLSVDCTPVTNQRASGRCWLFAATNHLRVNVVKELQLKDFELSQAYLFFYDKLEKANYFLDQITQSHEEPVDSRLVQYLLTDPTQDGGQYSMFLNIVKKYGLIPKDLYNDAAYSTTASRKWNSILTSKLREFAETIRETLKTKDVESKEFKELRTSMQKEIFRLMTLFMDLPPVKPDEKFTWTYQDKDKKVHTIESTPLEFASKYAKLDAAKPVSLINDPRNPYGKLIKIDRLGNVIGGEETLYLNVDNKTLTDLIVKRLKNDKPVFFGSHTPKYMDKKTGVMDIDLWNYHAIKYDLKQSKASRIEYHESLMTHAMLITAAHVDDDGNPVRFCVENSWGKDSGKDGMYVMTPEYFEEYCYQIVVDIDELPTDLAEKFDDKEPIVLPIWDPMGALAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP20</accession>
    <name>ATG4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Probable cysteine protease ATG4</fullName>
            <ecNumber>3.4.22.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Autophagy-related protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATG4</name>
        <name type="ordered locus">CAGL0J07304g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448024.1">
        <property type="nucleotide sequence ID" value="XM_448024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP20"/>
    <dbReference type="SMR" id="Q6FP20"/>
    <dbReference type="FunCoup" id="Q6FP20">
        <property type="interactions" value="331"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP20"/>
    <dbReference type="MEROPS" id="C54.001"/>
    <dbReference type="EnsemblFungi" id="CAGL0J07304g-T">
        <property type="protein sequence ID" value="CAGL0J07304g-T-p1"/>
        <property type="gene ID" value="CAGL0J07304g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889587"/>
    <dbReference type="KEGG" id="cgr:2889587"/>
    <dbReference type="CGD" id="CAL0132844">
        <property type="gene designation" value="CAGL0J07304g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07304g"/>
    <dbReference type="eggNOG" id="KOG2674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021259_5_3_1"/>
    <dbReference type="InParanoid" id="Q6FP20"/>
    <dbReference type="OMA" id="CKINESE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0788">Thiol protease</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000215859" description="Probable cysteine protease ATG4">
        <location>
            <begin position="1"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9Y4P1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="483" mass="54515" checksum="BD200D7CB53423B0" modified="2004-07-19" version="1">METIHNISNRLQEVLATNKSVNVDTDNDSLSSNQEDNEVEKVRHLVVILGEKYSYAVDRNTGINALMQWFTTNSEIPEEILNAIRSKLNFTYRTNFEPIERAPDGPSPINPLIMLRINPIDAIENVFNNRECFFTDVGWGCMIRTGQSLLGNALQRVKSTVKDQPYIYEMDDTKEITDLFKDNTKSAFSLQNFVKCGRIYNKIAPGEWFGPATTATCIRYLIQENPCYGIEACYISVSSGDIFKENIQGMIDRYPNGNILILLGIKLGLDSVHERYWGEIKTMLESPFSVGIAGGRPSSSLYFFGYFDDTLLFFDPHNSQTALIDDFDESCHTENFGKLNFSDLDPSMLLGFLLPCSKWDEFQEFTSLLTIVNVLDGMDQYRDPDLNSNDIGNVELSPQLKLSQTPDAITDDDYVDIGALIQGNSMNINDRDNGYQEVQCKNQQIVIMDSLNETKPLEIEKVLVGQGTNLVNATTPCREAFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPE9</accession>
    <name>Q6FPE9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) endonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0J04356g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPE9"/>
    <dbReference type="FunCoup" id="Q6FPE9">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPE9"/>
    <dbReference type="KEGG" id="cgr:2889633"/>
    <dbReference type="CGD" id="CAL0133316">
        <property type="gene designation" value="CAGL0J04356g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04356g"/>
    <dbReference type="eggNOG" id="KOG1294">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010374_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPE9"/>
    <dbReference type="OMA" id="YTVWNTL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="461"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="12">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="12">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0133316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG60844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="505" mass="57268" checksum="FD13F3978862664E" modified="2004-07-19" version="1">MGAIDPLLPDNIRFVTFNVNGVRTFFHYAPFSEMRQSLRSVFDWFESDVITFQELKTEPLSLNKWGKVDGFYSFISIPQKRKGYSGVGCWVRIPPRDSPKYNALQVLRAEEGITGYLEVKNGKQSVSYRDDSEIGIGGYIPDDSLPDHISTSDALQLDSEGRCVIVELKCGIVVISVYCPANSTCTDEGEVFRMRYLKLLFARIRNLQMMGKMVVLMGDLNICRDLIDHAVSLEEYHISIGNESTGTQIDEEYRDFAIKFIVNPEVPHRLLLNQILDDSMVPNTDNEFCLIDTTRKVQGRDRLKMYTVWNTLKNTRPSNFGSRIDFILVSKDLGNNIEKADILPDINGSDHCPVFCDINLNNLTLTSNISVEEKIPKFEARYRYNMTNRNIFDMFAKKSGKSSSSIGNKLKSEPIKDKVSKPIHKRSAEAITDKMGTTPNQTPKDKIALFFQGSFGPPPLCKHKQHAILKTSKTSNNPGKKFWTCSKPRGHQNDENSSCGFFEWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPG4</accession>
    <name>Q6FPG4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HMG2-induced ER-remodeling protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J04026g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPG4"/>
    <dbReference type="FunCoup" id="Q6FPG4">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889667"/>
    <dbReference type="CGD" id="CAL0129501">
        <property type="gene designation" value="CAGL0J04026g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04026g"/>
    <dbReference type="eggNOG" id="ENOG502QYHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007231_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPG4"/>
    <dbReference type="OMA" id="LMRNMQR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF30">
        <property type="entry name" value="GLC7-INTERACTING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
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                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPS6"/>
    <dbReference type="FunCoup" id="Q6FPS6">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPS6"/>
    <dbReference type="KEGG" id="cgr:2889837"/>
    <dbReference type="CGD" id="CAL0129577">
        <property type="gene designation" value="CAGL0J01309g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01309g"/>
    <dbReference type="eggNOG" id="ENOG502QW07">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022149_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FPS6"/>
    <dbReference type="OMA" id="STNWLYQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="50587" checksum="634E52AC54D4FEAD" modified="2004-07-19" version="1">MSDSETKLRSRSGSQKPDYKIDTEGLEIRDDDDNDVDYHEHDAEHDGEDGSGRKKRSREDDDEDEDVSLEDDDEDEDEDDEDDGGKSEAREGPHKRARAKRARSATPMGGAGSTRKSEISYPIDEEGHLLPVYKYEYETLEDPEGEKKITADGDLLDGREFTIRSFAIAENNAQKFMLSTEVARTMGYRDSYMFFQYHPSVYKFVLGQNQKNHLIDQNIIPYSYRSRKITIVAAKSIYKEFGAKVIKSGKSPHDDYYVTVFPVRGQKPKPTASDLKRQEKQKSATATPTELPKKQSPLLSNPTFLEYRNSVANTFTGNSKLNSTNWLYQHAAACSRFNSDLYYDRVRVLLIEQQGLRDPYTNTLHIPQNVQSTKVLDWYKEVDEEQEPNEDAITCETIIKSSNIARPKTNLCDVAPEIYEGVVDEETKKAILAQQEYERQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQH4</accession>
    <name>Q6FQH4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PIR1</name>
        <name evidence="10 11" type="ordered locus">CAGL0I06204g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447520.1">
        <property type="nucleotide sequence ID" value="XM_447520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQH4"/>
    <dbReference type="FunCoup" id="Q6FQH4">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQH4"/>
    <dbReference type="GeneID" id="2889152"/>
    <dbReference type="KEGG" id="cgr:2889152"/>
    <dbReference type="CGD" id="CAL0130077">
        <property type="gene designation" value="PIR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06204g"/>
    <dbReference type="eggNOG" id="ENOG502QQD8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039662_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQH4"/>
    <dbReference type="OMA" id="GSNDIFY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000420">
        <property type="entry name" value="Yeast_PIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00399">
        <property type="entry name" value="PIR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00929">
        <property type="entry name" value="PIR_REPEAT_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50256">
        <property type="entry name" value="PIR_REPEAT_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="9">
        <location>
            <begin position="265"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0130077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="349" mass="35763" checksum="9684630533950FB5" modified="2004-07-19" version="1">MQYKKTLAASALATSALAAYVPGKPWSTLTPSATFKGGITDYASTFGIAVQPIATPASVAKRAVSQIGDGQVQATTKTTSTLAPKAPISQIGDGQIQATTKTQAAPVSQIGDGQIQATTKTKAAPVSQIGDGQIQATTKTQAAPVSQIGDGQIQATTKTQAAPVSQIGDGQIQATTKTQAAPVSQIGDGQIQATTKTKATGVSQIGDGQIQATKTGSTTPSQPPMNNSTIPVPNNNATLPVNAKDPVRAESCKVDGTLEMNLKGGILTDGKGRIGSIVANRQFQFDGPPPQAGAIFAAGWSLTPEGNLAIGDNDVFYQCLSGNFYNLYDQHIGSQCTPVHLSAIDLIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQL5</accession>
    <name>Q6FQL5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chromatin structure-remodeling complex protein RSC8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0I05258g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447479.1">
        <property type="nucleotide sequence ID" value="XM_447479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQL5"/>
    <dbReference type="STRING" id="284593.Q6FQL5"/>
    <dbReference type="KEGG" id="cgr:2889202"/>
    <dbReference type="CGD" id="CAL0132690">
        <property type="gene designation" value="CAGL0I05258g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05258g"/>
    <dbReference type="eggNOG" id="KOG1279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004447_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FQL5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF150">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX PROTEIN RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIRM" evidence="9">
        <location>
            <begin position="69"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="10">
        <location>
            <begin position="286"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="291"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0132690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="58141" checksum="9D0088C13E824A53" modified="2004-07-19" version="1">MSTAEYCRVLQVRVKQRIHQSNMASVGDTVGSGEAVVGGAEKRKMSYVEEAEKLQEKTYRFMAKQTHPVIIPSYASWFDLCSVHQIEKDAVPDFFNGSSPIYKTPKSYMEARNFMVNTFRLAPYEYLTITAVRRNLTLDVASVMKIHSLLENWGLINYQVDPRAKQTLRGKKYFGNYKTVLDVPESLQPHLTDENMKDVAVDISVQMKQYNSTNDYNLLVSNHNSHSLTKPKIYVCFTCGNDIGQVMYHNLRAKEMNICSRCFKEGHFSSNFQASDFIKLNNVNNTNDKIWTDEELLLLLEGIELYEDKWDKIADHVGHFKTVEECVQKFLILPIEDRFIRDTISSETKRKNVGVSVSQDNISAFKDLIENNASEPVNPIENETYEKLERLTTILVEKITDKLSVIDEADSKLIATKGTFFKDSEKLLNDKISLNKQTIELNNELKSKKIYKTIKSSNSKDIHLVLKDNSEIRHEQELDSSHLSKLVSRDSDAVSIRNSEAYRPLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQT4</accession>
    <name>Q6FQT4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0I03718g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQT4"/>
    <dbReference type="FunCoup" id="Q6FQT4">
        <property type="interactions" value="1375"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQT4"/>
    <dbReference type="KEGG" id="cgr:2889149"/>
    <dbReference type="CGD" id="CAL0132570">
        <property type="gene designation" value="CAGL0I03718g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03718g"/>
    <dbReference type="eggNOG" id="KOG0292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007565_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQT4"/>
    <dbReference type="OMA" id="EMTYQKQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="205"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="13">
        <location>
            <begin position="343"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="15">
        <location>
            <begin position="627"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="842"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="840"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0132570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG60347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1201" mass="134960" checksum="C09C6D940B66FA9C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQY0</accession>
    <name>Q6FQY0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0I02574g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQY0"/>
    <dbReference type="FunCoup" id="Q6FQY0">
        <property type="interactions" value="894"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQY0"/>
    <dbReference type="KEGG" id="cgr:2889387"/>
    <dbReference type="CGD" id="CAL0129979">
        <property type="gene designation" value="CAGL0I02574g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02574g"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQY0"/>
    <dbReference type="OMA" id="LTRCMAG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="17"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0129979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="401" mass="45229" checksum="CF2EE0038641883F" modified="2004-07-19" version="1">MPFVKDFKPIALKDTNMFKPIKIGNTEVAHRVVMPPLTRMRAHHPGNVPNKEWAVEYYKQRSQRPGTMIITEGAFPCAQAGGYDNAPGIWSEEQVAEWTKIFKAIHDNKSFVWVQLWVLGRQAFPDTLARDGLRYDSASDEVYMDKESEEKAKKSNNPQHGITKDEIKQYIKDYVQAAKNSIAAGADGVEIHSANGYLLNQFLDPISNKRTDEYGGSIENRARFTLEVVDAIVDAIGPEKTGIRFSPYGTFGTMSGGAEPLIVAQYAYVLGELEKRAKAGKKLAFVHLVEPRVTNPFFTEGQGEYKDGTNDFAYSIWTGPIIRAGNYALHPEIAKEHVNNDDRTLIGYGRFFIANPDIVDRIEKGLPLNKYDRDTFYAMTTEGYLDYPTYDEAIKMGWDKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR44</accession>
    <name>PP4R3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein phosphatase 4 regulatory subunit 3</fullName>
            <shortName>PP4R3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PSY2</name>
        <name type="ordered locus">CAGL0I01056g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Regulatory subunit 3 (R3) of the histone H2A phosphatase complex (HTP-C) consisting of PPH3, PSY2 and PSY4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447300.1">
        <property type="nucleotide sequence ID" value="XM_447300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR44"/>
    <dbReference type="FunCoup" id="Q6FR44">
        <property type="interactions" value="970"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR44"/>
    <dbReference type="EnsemblFungi" id="CAGL0I01056g-T">
        <property type="protein sequence ID" value="CAGL0I01056g-T-p1"/>
        <property type="gene ID" value="CAGL0I01056g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888910"/>
    <dbReference type="KEGG" id="cgr:2888910"/>
    <dbReference type="CGD" id="CAL0132566">
        <property type="gene designation" value="CAGL0I01056g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01056g"/>
    <dbReference type="eggNOG" id="KOG2175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004909_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FR44"/>
    <dbReference type="OMA" id="YHRYMIS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000002">
        <property type="term" value="P:negative regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902660">
        <property type="term" value="P:negative regulation of glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001034">
        <property type="term" value="P:positive regulation of double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000455">
        <property type="entry name" value="Psy2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055236">
        <property type="entry name" value="EVH1_PP4R3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22972">
        <property type="entry name" value="EVH1_PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000223656" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3">
        <location>
            <begin position="1"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <sequence length="842" mass="96559" checksum="D83F1AAACAD2083A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR85</accession>
    <name>Q6FR85_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PUB1</name>
        <name evidence="5 6" type="ordered locus">CAGL0H10604g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447259.1">
        <property type="nucleotide sequence ID" value="XM_447259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR85"/>
    <dbReference type="FunCoup" id="Q6FR85">
        <property type="interactions" value="957"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR85"/>
    <dbReference type="GeneID" id="2888479"/>
    <dbReference type="KEGG" id="cgr:2888479"/>
    <dbReference type="CGD" id="CAL0131936">
        <property type="gene designation" value="PUB1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10604g"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025000_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FR85"/>
    <dbReference type="OMA" id="RINWASK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12622">
        <property type="entry name" value="RRM3_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000599">
        <property type="entry name" value="Poly(A) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="58"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="146"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="315"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="416" mass="46779" checksum="EF323722A44B24A1" modified="2004-07-19" version="1">MSEEIKNEVIETPEEVIEKPEEVSQEVEGDNASQENDDDKPSVVPASATKGGRETSDRVLYVGNLDKSITEDLLKQYFQAGGPIQNVKIIEDMKNEYVNYAFVEYIRSHDANVALQTLNGVQLENKTLKINWAFETQQAAENDDTFNLFVGDLNVDVDDETLAGTFREFPTFIQAHVMWDMQTGRSRGYGFVSFSNQEEAQKAMDAMQGKDLSGRQIRINWATKRERNMGNNFGNNRGSRGGNFRPYGNQGHHNRNNRNMMPPAMGMPMDGLMPMQQGQQNGQQPNVQQQQPMVPPPVNPQAIEDMIRRAPPRVTTAYIGNIPHYATEADLIPLLQNFGFILDFTHYPEKGCCFIKYDTHEQAAVCIVALANFPFQGRNLRTGWGKERTNFMPPQGAPGQQMPVMMDPSQAPPAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR87</accession>
    <name>Q6FR87_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0H10560g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR87"/>
    <dbReference type="FunCoup" id="Q6FR87">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888782"/>
    <dbReference type="CGD" id="CAL0131834">
        <property type="gene designation" value="CAGL0H10560g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10560g"/>
    <dbReference type="eggNOG" id="ENOG502SA5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150136_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR87"/>
    <dbReference type="OMA" id="MDIFAYF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="144" mass="16541" checksum="895935BC86A86DA6" modified="2004-07-19" version="1">MDFFKFLIVLVIVVLFILVLPWLSGIGSYSIQKAAVSNKKSPDSRREKLKNKLDKSVALNFSLKDKNDESDGKSSHVSKRGEFDIDSKTGLKRRVLSRYDQDPNNFDFDIDELIDEDRKEEAKEEQQRIKKFGGKSSEAYEGFV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR93</accession>
    <name>ATG20_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATG20</name>
        <name type="ordered locus">CAGL0H10428g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Functions in protein retrieval from the endocytic pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447251.1">
        <property type="nucleotide sequence ID" value="XM_447251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR93"/>
    <dbReference type="FunCoup" id="Q6FR93">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR93"/>
    <dbReference type="EnsemblFungi" id="CAGL0H10428g-T">
        <property type="protein sequence ID" value="CAGL0H10428g-T-p1"/>
        <property type="gene ID" value="CAGL0H10428g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888784"/>
    <dbReference type="KEGG" id="cgr:2888784"/>
    <dbReference type="CGD" id="CAL0130256">
        <property type="gene designation" value="CAGL0H10428g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10428g"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014456_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FR93"/>
    <dbReference type="OMA" id="CRRMKEV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010009">
        <property type="term" value="C:cytoplasmic side of endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000213821" description="Autophagy-related protein 20">
        <location>
            <begin position="1"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="283"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="753" mass="84641" checksum="B68985FA37415151" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRA1</accession>
    <name>Q6FRA1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TRM7</name>
        <name evidence="9 10" type="ordered locus">CAGL0H10252g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_447243.1"/>
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    <dbReference type="KEGG" id="cgr:2888674"/>
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        <property type="gene designation" value="CAGL0H10252g"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_009422_1_2_1"/>
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        <property type="component" value="Chromosome H"/>
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        <property type="term" value="P:wobble position ribose methylation"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
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    </dbReference>
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        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
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        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="8">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
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    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF01728"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0131666"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60176.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="309" mass="34863" checksum="FE365574DFFDE73A" modified="2004-07-19" version="1">MGKSSKDKRDLYYRKAKEEGYRARSAYKLLQLNEEFHFLDDPELKRVVDLCAAPGSWSQVLSRKLFAEREPVADGQEDDRKIIAVDLQPMSPIDHVITLQADITHPRTLERIYELFGNQKADFVCSDGAPDVTGLHDLDEYIQHQLIMSALQLTTCVLKRGGTFVAKIFRGRDIDMLYSQLGYLFEKIVCAKPRSSRGTSLEAFIVCIGYNPPAGWEPKLDVNSSVTEFFATCDLGKLSIDDTLQPWKDQPRSIADFMACGSLSSYDSDATYHDLPKYGVALDPVQAPTNPPYKRALELKRDGKLTRNI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2025-06-18" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRM0</accession>
    <name>MKAR_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.1.1.330</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">3-ketoacyl-CoA reductase</fullName>
            <shortName evidence="4">3-ketoreductase</shortName>
            <shortName evidence="4">KAR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Microsomal beta-keto-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">CAGL0H07513g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="EC" id="1.1.1.330"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endoplasmic reticulum membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.330" evidence="4"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRM0"/>
    <dbReference type="SMR" id="Q6FRM0"/>
    <dbReference type="FunCoup" id="Q6FRM0">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRM0"/>
    <dbReference type="EnsemblFungi" id="CAGL0H07513g-T">
        <property type="protein sequence ID" value="CAGL0H07513g-T-p1"/>
        <property type="gene ID" value="CAGL0H07513g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888772"/>
    <dbReference type="CGD" id="CAL0131832">
        <property type="gene designation" value="IFA38"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H07513g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07513g"/>
    <dbReference type="eggNOG" id="KOG1014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_38_0_1"/>
    <dbReference type="InParanoid" id="Q6FRM0"/>
    <dbReference type="OMA" id="LVAPGMM"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141040">
        <property type="term" value="F:very-long-chain 3-oxoacyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000357303" description="Very-long-chain 3-oxoacyl-CoA reductase">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Lowers pKa of active site Tyr" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="L0E2Z4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="O93868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P38286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03107"/>
        </source>
    </evidence>
    <sequence length="352" mass="39332" checksum="AAA96B74AE86CCA5" modified="2004-07-19" version="1">MTFVRELEVASQNSRAFNVTLWFIFIFGLLKLVPFALRFLSMVFDLFVLPPVNYAKYGCKAGDYAVVTGASDGIGKEFASQLASKGFNLVLISRTESKLVALKDELEGKFNIKAKILAIDISADSKDNYNKIYSLCDDLPISILVNNVGQSHSIPVPFLATEEEEMRNIITINNTATLMITQIIAPIIIRTVKKHRESGDKKLKSQRGLILTMGSFGGLIPTPLLATYSGSKAFLQNWSSSLAGELAADNVDVELVLSYLVTSAMSKVRRTSMMIPNPRTFVKSTLRNIGRRCGAQDRYGTITPFWSHAIYHFVIEELFGVYARVVNEINYKFHKSIRIRAVRKAVREAKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRZ0</accession>
    <name>Q6FRZ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0H04807g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRZ0"/>
    <dbReference type="FunCoup" id="Q6FRZ0">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRZ0"/>
    <dbReference type="KEGG" id="cgr:2888502"/>
    <dbReference type="CGD" id="CAL0130500">
        <property type="gene designation" value="CAGL0H04807g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04807g"/>
    <dbReference type="eggNOG" id="KOG1331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029501_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FRZ0"/>
    <dbReference type="OMA" id="VHEVYQQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006448">
        <property type="term" value="P:regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="46"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0130500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="269" mass="31048" checksum="B6E440969651D53A" modified="2004-07-19" version="1">MADLKEEEYVHKVYNEIAPHFSETRYKPWPIVTDFLMTRPMGSVGIDVGCGNGKYLNVNPNIYIIGSDRSSGLIQCAHEIDPINYNVLVADGMRLPHLDNRFDFAISIAVVHHWTTRERRISAIKHILSKVRSGGQALIYCWALEQGNSRRGYHEGMEQDVLVPWVLQEKKKKEPTKKQSSQRAKPDLTNVAPQDRAAFVANWKKEQEQLRLKEEEAKQKNEEQKEDVKYRFYHLYKKGELEEDCEAAGAIVVRGGYEKDNWYVIAQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS53</accession>
    <name>Q6FS53_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Choline transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0H03399g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid/choline transporter (ACT) (TC 2.A.3.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS53"/>
    <dbReference type="FunCoup" id="Q6FS53">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888497"/>
    <dbReference type="CGD" id="CAL0131654">
        <property type="gene designation" value="CAGL0H03399g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03399g"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004495_2_4_1"/>
    <dbReference type="InParanoid" id="Q6FS53"/>
    <dbReference type="OMA" id="GIPWIAF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901235">
        <property type="term" value="F:(R)-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015220">
        <property type="term" value="F:choline transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034228">
        <property type="term" value="F:ethanolamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031460">
        <property type="term" value="P:glycine betaine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004756">
        <property type="entry name" value="AA_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00907">
        <property type="entry name" value="2A0304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0131654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="61429" checksum="FA1AB83A32501295" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSB2</accession>
    <name>Q6FSB2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H01947g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446882.1">
        <property type="nucleotide sequence ID" value="XM_446882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSB2"/>
    <dbReference type="FunCoup" id="Q6FSB2">
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    </dbReference>
    <dbReference type="KEGG" id="cgr:2888899"/>
    <dbReference type="CGD" id="CAL0131846">
        <property type="gene designation" value="CAGL0H01947g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01947g"/>
    <dbReference type="eggNOG" id="ENOG502S6F0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100331_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FSB2"/>
    <dbReference type="OMA" id="NENSEMH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="204" mass="22620" checksum="3FDAB805D368E0F4" modified="2004-07-19" version="1">MERLNSLERSLPPEQPPTEKAIATLNSELSQEFKLAANSVTKLYRLANERASLVRHQGYLDCVEDVLSLIDGSTGSNGSNGSKEPTVEDIREWCLKRRQEMLSSKDGRVDSHRSDGRGGQGRVAPKVDFHLQKSFLGKTEVPQGGKIEVPTFKLGKPPLSVEHHARPGRRRQLNTPAATNTTFTSTPNNENSEMHESVPKKPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSF0</accession>
    <name>Q6FSF0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease H2 subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribonuclease HI subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0H01023g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSF0"/>
    <dbReference type="FunCoup" id="Q6FSF0">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSF0"/>
    <dbReference type="KEGG" id="cgr:2888570"/>
    <dbReference type="CGD" id="CAL0131802">
        <property type="gene designation" value="CAGL0H01023g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01023g"/>
    <dbReference type="eggNOG" id="ENOG502RB2X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_802143_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSF0"/>
    <dbReference type="OMA" id="DNHDKNW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09270">
        <property type="entry name" value="RNase_H2-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040456">
        <property type="entry name" value="RNase_H2_suB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019024">
        <property type="entry name" value="RNase_H2_suB_wHTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09468">
        <property type="entry name" value="RNase_H2-Ydr279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="8">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Ribonuclease H2 subunit B wHTH" evidence="7">
        <location>
            <begin position="143"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0131802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="344" mass="39326" checksum="748F71701A977F64" modified="2004-07-19" version="1">MTIEDEQKRVGIEGICLLPSEIKLLSEAYFFELPASSNNESSSTTKLLKYGTEIYQVTDYCFGKGRKYEKVKDEINDRYHYDEEGKPLRSAIHVNSEDKTNYTVLPNANIKYFSKYDLTYNLIGFKFKDCVTGKESEYFKPTHKETTKKDDDRYLTLRDHQDMLIDNGHANWSQIPSPTLEHCLSNISDQIEEAGDKYYKITLDKILNYLKLKIVNIVENFPNSISVPPSLDKNDLNAFKIFIASNILVSLVPKIIFVSLQDDDIPIEKYDISVKQAFHDIEVFYKTSTDKDAEQKILLEAATNVGMPGDSGPRQMDKKPKKVVPKKPKVAVGRGAIDGFFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSF5</accession>
    <name>Q6FSF5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H00913g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSF5"/>
    <dbReference type="STRING" id="284593.Q6FSF5"/>
    <dbReference type="KEGG" id="cgr:2888460"/>
    <dbReference type="CGD" id="CAL0131946">
        <property type="gene designation" value="CAGL0H00913g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00913g"/>
    <dbReference type="eggNOG" id="ENOG502S4TX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1001148_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSF5"/>
    <dbReference type="OMA" id="RIVMERC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="1">
        <location>
            <begin position="85"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="278" mass="31311" checksum="68B2E1DE217A3CA1" modified="2004-07-19" version="1">MDIAQQLRRLEDTAEEAQEQWLAELDCAYAQFNERIADLTKYDREKCKRRFDALFAWRNSGGGSGGGSGQGPHGQRLRFRFKHTPRLKTSTEAPAGDPAARSTPPLQHVDAVLELSEMQMKRVFNLDRLDRCVVLYDGASNDAMSAFSMAHARNTVVSLNVPQMLGSIFVTDCEHTTLLIRLRFGEKVQIRLHNLVNCQIQVEPADNTASAQTVIIEDCDEVTFHSTAQDLIAIRNFNVFKAHTDKPPYKWGPPLPDQDQDPIKLREAYIAAERGIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSK1</accession>
    <name>Q6FSK1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="16">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0G09955g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="16"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSK1"/>
    <dbReference type="FunCoup" id="Q6FSK1">
        <property type="interactions" value="914"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSK1"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888141"/>
    <dbReference type="CGD" id="CAL0137723">
        <property type="gene designation" value="CAGL0G09955g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09955g"/>
    <dbReference type="eggNOG" id="KOG2978">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_13_1_1"/>
    <dbReference type="InParanoid" id="Q6FSK1"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000119">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="18">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0137723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG59720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="265" mass="29457" checksum="B94E3905EDDD1DB8" modified="2004-07-19" version="1">MSIENSVIVPAYHEKLNIKPLTTRLFAALGNEGSKITELIFVDDNSQDGSVEEVEALHKQGYNVRIIVRTDERGLSSAVLKGFHEAKGEYLICMDADLQHPPESVPSLFDSLRKHPFVLGTRYAPGVGIDKDWPLHRRVISSTARMMARPLTTASDPMSGFFGLQKKYLTKANPQDINSQGFKIALELLAKLPLPANEPIGEIPFSFGVRVEGESKLSGKVIIQYLEQLKELYVFKYGANTLIAVFAIAVLLALYILLKLRSLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT43</accession>
    <name>Q6FT43_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G05522g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446601.1">
        <property type="nucleotide sequence ID" value="XM_446601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT43"/>
    <dbReference type="KEGG" id="cgr:2888148"/>
    <dbReference type="CGD" id="CAL0130685">
        <property type="gene designation" value="CAGL0G05522g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05522g"/>
    <dbReference type="HOGENOM" id="CLU_2413045_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT43"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="92" mass="10320" checksum="36C4A1E55DC92F0B" modified="2004-07-19" version="1">MELDIQWASEVHDYRIKQRDPWETHKGTIAIVLPLGSPLFLQSFVVVTFTRNGLPAWRTHMPTINTSLQDATCLPSPPRGVIAVTGYGKCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTP2</accession>
    <name>Q6FTP2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0G00946g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTP2"/>
    <dbReference type="FunCoup" id="Q6FTP2">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTP2"/>
    <dbReference type="KEGG" id="cgr:2888304"/>
    <dbReference type="CGD" id="CAL0137687">
        <property type="gene designation" value="CAGL0G00946g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00946g"/>
    <dbReference type="eggNOG" id="KOG3355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070631_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTP2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160203">
        <property type="term" value="P:mitochondrial disulfide relay system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="68"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0137687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="174" mass="19715" checksum="506A5280460AD18C" modified="2004-07-19" version="1">MSPEEGLTGRKIIYDEDGKPCRSCNTLLDFKFATGTISKAGSVIPAMAATDNSAEELIPGSKTYKKIDPPDVQQLGASSWSLLHSIAAKYPKTPSETQQKEMSQFLNIFSHIYPCNWCAADFEKYIRENAPKVSSREELGRWMCDAHNKVNVKLGKPKFNCDFWEKRWKDGWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTP3</accession>
    <name>Q6FTP3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GLM5</name>
        <name evidence="6 7" type="ordered locus">CAGL0G00924g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTP3"/>
    <dbReference type="FunCoup" id="Q6FTP3">
        <property type="interactions" value="692"/>
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    <dbReference type="STRING" id="284593.Q6FTP3"/>
    <dbReference type="KEGG" id="cgr:2888033"/>
    <dbReference type="CGD" id="CAL0137583">
        <property type="gene designation" value="GLM5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00924g"/>
    <dbReference type="eggNOG" id="KOG2141">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006786_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FTP3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097078">
        <property type="term" value="C:FAL1-SGD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="940"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="257"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="492"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="566"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
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            <end position="299"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="422"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0137583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1196" mass="136559" checksum="C9CD4CEB7FF25384" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTQ8</accession>
    <name>EFG1P_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>rRNA-processing protein EFG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EFG1</name>
        <name type="ordered locus">CAGL0G00484g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EFG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_446386.1"/>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTQ8"/>
    <dbReference type="EnsemblFungi" id="CAGL0G00484g-T">
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        <property type="gene ID" value="CAGL0G00484g"/>
    </dbReference>
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    <dbReference type="KEGG" id="cgr:2888404"/>
    <dbReference type="CGD" id="CAL0130825">
        <property type="gene designation" value="CAGL0G00484g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00484g"/>
    <dbReference type="eggNOG" id="KOG4484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066912_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FTQ8"/>
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        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071027">
        <property type="term" value="P:nuclear RNA surveillance"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000321">
        <property type="term" value="P:re-entry into mitotic cell cycle after pheromone arrest"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Efg1"/>
    </dbReference>
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        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000330266" description="rRNA-processing protein EFG1">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="24"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="229" mass="26579" checksum="7A3C99B8484D22FD" modified="2004-07-19" version="1">MSGVRMQKKNRRALGQSLEMAQFLDSGSNKIKRRIRDLERLLKKKKDILPSNIIVEKERTLEALRLELHNHEVKENIRKNAKKYHMVRFFERKKALRRYKKALKTYKADENEANKEALENAEVDLCYVVNFPKSEKYISIFTEDDTEASAETNLRRKAFRQLVRGKIADKSLPVSLSNILAGKKLSEEAIGVTLDDALSRSNQTDASHQESDEDSDSNENEKEEDDFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTS9</accession>
    <name>Q6FTS9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0F09141g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446365.1">
        <property type="nucleotide sequence ID" value="XM_446365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTS9"/>
    <dbReference type="KEGG" id="cgr:2887852"/>
    <dbReference type="CGD" id="CAL0129701">
        <property type="gene designation" value="CAGL0F09141g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F09141g"/>
    <dbReference type="HOGENOM" id="CLU_2775709_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTS9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0129701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="69" mass="7991" checksum="1123C7272E7B794D" modified="2004-07-19" version="1">MKNADCRLFTFYCLNPTPFLTHYFRYQFKNSPNSRTLLLTQECLGTLFKDSPKNLLSHVTLVKGSNTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTT6</accession>
    <name>Q6FTT6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0F08987g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTT6"/>
    <dbReference type="FunCoup" id="Q6FTT6">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTT6"/>
    <dbReference type="KEGG" id="cgr:2887901"/>
    <dbReference type="CGD" id="CAL0131364">
        <property type="gene designation" value="CAGL0F08987g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08987g"/>
    <dbReference type="eggNOG" id="KOG1772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125101_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FTT6"/>
    <dbReference type="OMA" id="EHMGSKD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.620:FF:000004">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.620">
        <property type="entry name" value="F1F0 ATP synthase subunit B, membrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.730">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0131364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="114" mass="12908" checksum="8B8E41E7BD2EE684" modified="2004-07-19" version="1">MSQKNGIATLLKAEKEAHEIVTEARKYRQEKIKQAKLDASKEIENYKAKKEQELKDFESNNAGGVQELEKKADAEVQSELDEIKKTVESKKKQVVDLLLEAVTKPTTEVHINAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-05-10" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTV3</accession>
    <name>SFH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Chromatin structure-remodeling complex subunit SFH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>RSC complex subunit SFH1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>SNF5 homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SFH1</name>
        <name type="ordered locus">CAGL0F08569g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and required for cell cycle progression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446341.1">
        <property type="nucleotide sequence ID" value="XM_446341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTV3"/>
    <dbReference type="SMR" id="Q6FTV3"/>
    <dbReference type="FunCoup" id="Q6FTV3">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTV3"/>
    <dbReference type="EnsemblFungi" id="CAGL0F08569g-T">
        <property type="protein sequence ID" value="CAGL0F08569g-T-p1"/>
        <property type="gene ID" value="CAGL0F08569g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887854"/>
    <dbReference type="CGD" id="CAL0129348">
        <property type="gene designation" value="CAGL0F08569g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08569g"/>
    <dbReference type="eggNOG" id="KOG1649">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014421_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FTV3"/>
    <dbReference type="OMA" id="NFHNRIR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017393">
        <property type="entry name" value="Sfh1/SNF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038126">
        <property type="entry name" value="SWI_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000205958" description="Chromatin structure-remodeling complex subunit SFH1">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9USM3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="403" mass="44819" checksum="64A172A3F548B108" modified="2004-07-19" version="1">MSNRAVPQGYLANLQFRIRSDNLPLLSTVQPSRGHKRGGRAVNYAEFDNELLEDFSNFPTFDIDSDSNDEEQSSASAGNDDPQANANGGEAAGVNGQGSGDGGSANTGAGRHGKSQLTAEMEKNYKTGVPDLNEQKDSLNVLRYQKIRESFQHGKIAVPYRLYVPPELSTGQQEAILIPITLNVEHGNNTISDAFVWNVNDTSISVEDFVTTYCNDLGLYGNVSLHSQIVSSINEQIQELENVASLVIPDLEVVVNLTCTIQGKFFEDYFQWNLSDKSLSPEKFALIIVADLGLAREFAPGIAHSLHEYLLHVKKEWAEGSLHQDTVPNEAAFGYLAGVRLNIDDLGAKWAPKVEYLTQEEIQKREIEKERNMRRLKRESDRMGGGARRGRRRLDDLELTMKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTY4</accession>
    <name>Q6FTY4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">UPC2B</name>
        <name evidence="3 4" type="ordered locus">CAGL0F07865g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTY4"/>
    <dbReference type="SMR" id="Q6FTY4"/>
    <dbReference type="STRING" id="284593.Q6FTY4"/>
    <dbReference type="KEGG" id="cgr:2887701"/>
    <dbReference type="CGD" id="CAL0131362">
        <property type="gene designation" value="UPC2B"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07865g"/>
    <dbReference type="eggNOG" id="ENOG502QRM1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011669_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTY4"/>
    <dbReference type="OMA" id="EVWPTIT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070452">
        <property type="term" value="P:positive regulation of ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900436">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000911">
        <property type="term" value="P:positive regulation of sterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="844" mass="93766" checksum="FAC3320FEB5A179F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU60</accession>
    <name>Q6FU60_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator p15 (PC4) C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0F06039g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU60"/>
    <dbReference type="FunCoup" id="Q6FU60">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU60"/>
    <dbReference type="KEGG" id="cgr:2887726"/>
    <dbReference type="CGD" id="CAL0129404">
        <property type="gene designation" value="CAGL0F06039g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06039g"/>
    <dbReference type="eggNOG" id="KOG2712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065855_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU60"/>
    <dbReference type="OMA" id="MNRADDD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075297">
        <property type="term" value="P:negative regulation of ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051053">
        <property type="term" value="P:negative regulation of DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045945">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.31.10:FF:000003">
        <property type="entry name" value="SUB1p Transcriptional coactivator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0129404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="277" mass="30918" checksum="D662ED29B079D6CF" modified="2004-07-19" version="1">MSYYSRYRKKNNNNGGASPGNNGGNLNLAAGLGQPDAIFDLGKNKRVTVRQFRNINLIDIREYYMDNATGEMRPGKKGISLTEDLYDEFLRHRLNIDDALRRLGSKRPRTKTVRLLSDDEDEEADEKPISSSSEKQEAIRENKDKDSNKNSASTNSKKHKKEGEEVEEPKKKQKKPAPPTLLPHEEKIRNLELEANATIIVPSKGKVTPPPTSDAQSQPQLPPLATVSDAPAHTESTTGKADIANLVDHHDNSTDEEFAKTLEAEMNRADDDESEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU76</accession>
    <name>Q6FU76_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0F05687g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05687g"/>
    <dbReference type="eggNOG" id="ENOG502QRGG">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018066_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU76"/>
    <dbReference type="OMA" id="NIYIHDG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="343"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="670"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="789" mass="89874" checksum="92982653D4FD8B3B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUF0</accession>
    <name>Q6FUF0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Phosphomevalonate kinase</fullName>
            <ecNumber evidence="3 13">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ERG8</name>
        <name evidence="15 16" type="ordered locus">CAGL0F03993g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP</text>
            <dbReference type="Rhea" id="RHEA:16341"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16342"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3 13"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446144.1">
        <property type="nucleotide sequence ID" value="XM_446144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUF0"/>
    <dbReference type="FunCoup" id="Q6FUF0">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUF0"/>
    <dbReference type="GeneID" id="2887874"/>
    <dbReference type="KEGG" id="cgr:2887874"/>
    <dbReference type="CGD" id="CAL0131034">
        <property type="gene designation" value="ERG8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03993g"/>
    <dbReference type="eggNOG" id="KOG4519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022059_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FUF0"/>
    <dbReference type="OMA" id="LVIHRTM"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031388">
        <property type="term" value="P:organic acid phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01219">
        <property type="entry name" value="Pmev_kin_ERG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="14">
        <location>
            <begin position="150"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR017288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0131034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG59068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="448" mass="49747" checksum="5BEA2A1AD43602B2" modified="2004-07-19" version="1">MKNMERAYSAPGKVLLVGGYLVLDPKYDSYVVAVSSRMHAVVSEEKYNETLDGFHIQFTSPQFNNECWNYSVNSQNGYVPVEVSGNRNPFLEKTVLNVLSFIGPASGKTFPNVIKIDIYSDAGYHSQNNSITRSNGLKSFQFHKTGIAQVPKTGLGSSAGLVVVCTTALLSCFLNDNPLLDELDLIHNLSQLSHCQAQGKIGSGFDVAAAVYGSIKYRRFQPDLISRLPTLSSDNYREYRFEMSKLIKSNWNIKHESIVLPAGLRLVLGDVRGGSETVELVKKVKLWYTNNYPRSEEIYNNINEANLSFIDAMLQLQQLQKADNDKYKGLLKAINTGNDQQFKEILHLKAAIAKIRENFRLITQESGADIEPEAQTKLLDACSQLNGVIGGVVPGAGGYDAVSIISTEDTNLNENTTSSEFDSVTWLDLKQEAVGLKLENPEYYRDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUP9</accession>
    <name>Q6FUP9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L1c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">RP4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">YL31</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0F01683g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58969.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUP9"/>
    <dbReference type="SMR" id="Q6FUP9"/>
    <dbReference type="FunCoup" id="Q6FUP9">
        <property type="interactions" value="753"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUP9"/>
    <dbReference type="KEGG" id="cgr:2887585"/>
    <dbReference type="CGD" id="CAL0130910">
        <property type="gene designation" value="CAGL0F01683g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01683g"/>
    <dbReference type="eggNOG" id="KOG3434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105624_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUP9"/>
    <dbReference type="OMA" id="YQLRFYN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000003">
        <property type="entry name" value="60S ribosomal protein L22-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00077545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0130910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58969.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="120" mass="13675" checksum="0214FC58D34D2AEF" modified="2008-09-23" version="2">MAPNTARKQKVVKTFTVDVSAPTENGVFDPASYAKYLIDHIKVENVVGNLGNAITVEEDGSVVTIVSTTKFSGKYLKYLTKKYLKKNQLRDWIRFVSTKTNSYRLAFYQVTPEEEEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUX6</accession>
    <name>Q6FUX6_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0E06402g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445968.1">
        <property type="nucleotide sequence ID" value="XM_445968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUX6"/>
    <dbReference type="KEGG" id="cgr:2887375"/>
    <dbReference type="CGD" id="CAL0128714">
        <property type="gene designation" value="CAGL0E06402g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06402g"/>
    <dbReference type="HOGENOM" id="CLU_2359492_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUX6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="96" mass="11011" checksum="8B1F5BCDCC5B9943" modified="2004-07-19" version="1">MYNEINECLTKQTSLPQFPPSIILANQLPRTSLTLYIQASSITRVRCIPTSVLQCNTFLNSPKVHFVGKGVVSIRHLMELQYFFTPYVYSLLILFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV13</accession>
    <name>Q6FV13_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">DNA repair protein REV1</fullName>
            <ecNumber evidence="14">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0E05588g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="14"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV13"/>
    <dbReference type="FunCoup" id="Q6FV13">
        <property type="interactions" value="909"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV13"/>
    <dbReference type="KEGG" id="cgr:2887536"/>
    <dbReference type="CGD" id="CAL0129034">
        <property type="gene designation" value="CAGL0E05588g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05588g"/>
    <dbReference type="eggNOG" id="KOG2093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003901_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FV13"/>
    <dbReference type="OMA" id="PPKYMGM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000023">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 14" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="80"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="258"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0129034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG58850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="887" mass="101825" checksum="D7A47B23D271464D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV28</accession>
    <name>Q6FV28_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0E05236g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445916.1">
        <property type="nucleotide sequence ID" value="XM_445916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV28"/>
    <dbReference type="FunCoup" id="Q6FV28">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV28"/>
    <dbReference type="KEGG" id="cgr:2887286"/>
    <dbReference type="CGD" id="CAL0129106">
        <property type="gene designation" value="CAGL0E05236g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05236g"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FV28"/>
    <dbReference type="OMA" id="MPAWRFM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="344" mass="39783" checksum="2CE932EB284582BD" modified="2004-07-19" version="1">MTTKLVKQIRFGASGLKISPIIIGCMSYGSKNWADWVLEDKEKIFGILKRAYDRGLRTYDTADMYSNGYSERLLKEFFEKYQIKRETVVIMSKVFYAVDEDLDLHHGLDINEVEDLHLTNQRGLSRRHILEAVKNSTERLGTYIDVLQIHRLDKETPMKEIMKALNDVVEAGYARYIGSSSMLATEFAELQFIAEKHNWFQFVSLQSFYNLLNREDEREIIPFAKRHNIALTPWSPNARGLLTRPVSKISVRIKSDPTFKIVGLDKLTEDQKEIINRVEEVAKKHNTSMAIISNSWVLSKGCNPIVGLNSIARVDEAIASIDFELPEEDIKYLEEPYLPKKFYY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-06-18" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV36</accession>
    <name>MED5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NUT1</name>
        <name type="synonym">MED5</name>
        <name type="ordered locus">CAGL0E05060g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445908.1">
        <property type="nucleotide sequence ID" value="XM_445908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV36"/>
    <dbReference type="SMR" id="Q6FV36"/>
    <dbReference type="FunCoup" id="Q6FV36">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV36"/>
    <dbReference type="EnsemblFungi" id="CAGL0E05060g-T">
        <property type="protein sequence ID" value="CAGL0E05060g-T-p1"/>
        <property type="gene ID" value="CAGL0E05060g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887379"/>
    <dbReference type="KEGG" id="cgr:2887379"/>
    <dbReference type="CGD" id="CAL0129110">
        <property type="gene designation" value="NUT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05060g"/>
    <dbReference type="eggNOG" id="ENOG502R1HB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_281615_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FV36"/>
    <dbReference type="OMA" id="FTCFAQF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000302771" description="Mediator of RNA polymerase II transcription subunit 5">
        <location>
            <begin position="1"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1099" mass="125498" checksum="92A4F440AB4ED6BC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV51</accession>
    <name>Q6FV51_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0E04708g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV51"/>
    <dbReference type="FunCoup" id="Q6FV51">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV51"/>
    <dbReference type="KEGG" id="cgr:2887511"/>
    <dbReference type="CGD" id="CAL0128628">
        <property type="gene designation" value="CAGL0E04708g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04708g"/>
    <dbReference type="eggNOG" id="ENOG502QQNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015737_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FV51"/>
    <dbReference type="OMA" id="WIGIKEI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39444" checksum="35CCD010C2E84FE9" modified="2004-07-19" version="1">MTSSKELLVKEDIHSIDKLPKIENYKAPKYPVVLCHGLSGFDKLILIPSVFRLTKMISSSINLNNSDHFLEIDDDTEGASVRNKGLLEIEYWIGIKEILEKNGCQTITTKVPGMGSIEERALALNASIEREVKKLQKKQKKNSWFSRNEKIKLNLLAHSMGGLDCRYLIAKLPKRNYQVASLTTISTPHRGSEMADYITKLFFDLKPKKESAPNIHLPICFYQLTTTYMQYFNENVRDDPKVKYFSYGSYFKPKWYNVLAWPWKVIAKATNDGLNDGLVTIKSSEWGEYQGTLKNVDHLDIINWKNKLQDDYLKYFPKIGYEPINILDFYLHVTDNLARNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV69</accession>
    <name>Q6FV69_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transcription factor STP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0E04312g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes, including the amino-acid permeases AGP1, BAP2, BAP3 and GNP1. Binding to promoters is facilitated by DAL81. Involved in the repression of genes subject to nitrogen catabolite repression and genes involved in stress response. Negatively regulated by inner nuclear membrane proteins ASI1, ASI2 and ASI3, which prevent unprocessed precursor forms that escape cytoplasmic anchoring from inducing SPS-sensor-regulated genes. May be involved in pre-tRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts (via Region II) with SSY5; protease component of the SPS-sensor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445875.1">
        <property type="nucleotide sequence ID" value="XM_445875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV69"/>
    <dbReference type="FunCoup" id="Q6FV69">
        <property type="interactions" value="793"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV69"/>
    <dbReference type="KEGG" id="cgr:2887531"/>
    <dbReference type="CGD" id="CAL0128556">
        <property type="gene designation" value="CAGL0E04312g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04312g"/>
    <dbReference type="eggNOG" id="ENOG502S1NP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025391_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FV69"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002194">
        <property type="entry name" value="STP1p Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="321"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0128556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG58794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="688" mass="76126" checksum="C5A9D6AB5AEA08D4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVE5</accession>
    <name>Q6FVE5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADIPOR-like receptor IZH2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0E02519g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVE5"/>
    <dbReference type="FunCoup" id="Q6FVE5">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVE5"/>
    <dbReference type="KEGG" id="cgr:2887489"/>
    <dbReference type="CGD" id="CAL0129122">
        <property type="gene designation" value="CAGL0E02519g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02519g"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023075_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FVE5"/>
    <dbReference type="OMA" id="EPWQQDN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF52">
        <property type="entry name" value="ADIPONECTIN RECEPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="36264" checksum="C8E5D8F202A33C5C" modified="2004-07-19" version="1">MGDVHQRKVATMVTTEEQPLIGTDGQIKLRKKTVVRKLYTWEEIPEWQKDNEHIHTGYVRETSSVMECIRSLFYLHNETVNIYSHLIPAIAFFSTIFFNKYVVPTYSTTTLIDYLIIDIFFLGAFSCLILSSTFHCLKSHSLRVAVFGNKLDYLGIVFLIVASMVSILYYGFHGNPWFFGIFSLITMTFGAACAVVSLKDTFRSREWRPYRAALFVIFGLSAVLPILAGLFKYGPTETWTRIQLKWVILEGVFYIFGAFLYGIRFPEKMSPGSFDLWGHSHQIFHILVVVAALCHLKALLGSYSLVHYRFMIDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVG0</accession>
    <name>Q6FVG0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0E02167g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVG0"/>
    <dbReference type="FunCoup" id="Q6FVG0">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVG0"/>
    <dbReference type="KEGG" id="cgr:2887280"/>
    <dbReference type="CGD" id="CAL0128960">
        <property type="gene designation" value="CAGL0E02167g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02167g"/>
    <dbReference type="eggNOG" id="KOG0011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1294717_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVG0"/>
    <dbReference type="OMA" id="NCMVSAP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000753">
        <property type="term" value="P:cell morphogenesis involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.70">
        <property type="entry name" value="Get5 dimerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040474">
        <property type="entry name" value="MDY2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031765">
        <property type="entry name" value="Mdy2_get4-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16843">
        <property type="entry name" value="Get5_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18514">
        <property type="entry name" value="MDY2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="67"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="202" mass="22293" checksum="0FD3CC74F1766918" modified="2004-07-19" version="1">MATPEFEFASKFLTLATLQEPKFAQNYQKPLKDVNSIGVALPALKYKYDPTRVSKQLPSGADATASVELTLKSIRPPKFTFTDKFGSDATVFTVKQRVVDEGHCRHIQSVKLLLKGKVLHDNMVLKDLGVSNAAITVMIAKEEEIKSTPPTIEARTPASVPWSDIQALLNNKVANADEAKTMFEQLQKGYELAQQSSTPQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVQ5</accession>
    <name>Q6FVQ5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0D06534g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445689.1">
        <property type="nucleotide sequence ID" value="XM_445689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVQ5"/>
    <dbReference type="KEGG" id="cgr:2887202"/>
    <dbReference type="CGD" id="CAL0128109">
        <property type="gene designation" value="CAGL0D06534g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D06534g"/>
    <dbReference type="HOGENOM" id="CLU_2249795_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVQ5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273550" evidence="2">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="104" mass="11295" checksum="CE55792FF113B8B5" modified="2004-07-19" version="1">MVLCSFLLQVFSCHVVNTRVKGIFQSFCGTDSYVQQPDLSFPTAQPTRLALPPQTTSVATHYQPASSLHLPAFDHSVPPCAGTSPPPLKSSEQTRTHLDAQKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVV8</accession>
    <name>Q6FVV8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0D05214g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVV8"/>
    <dbReference type="FunCoup" id="Q6FVV8">
        <property type="interactions" value="615"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVV8"/>
    <dbReference type="KEGG" id="cgr:2887045"/>
    <dbReference type="CGD" id="CAL0128523">
        <property type="gene designation" value="CAGL0D05214g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05214g"/>
    <dbReference type="eggNOG" id="KOG3504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169255_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FVV8"/>
    <dbReference type="OMA" id="PRTNKYP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0128523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="59" mass="6746" checksum="8B1D583EDB5F4F98" modified="2004-07-19" version="1">MAKSKNHTAHNQTRKAHRNGIKKPKTYKYPSLKGVDPKFRRNHRHALRGTAKTLAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVZ0</accession>
    <name>Q6FVZ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GCV1</name>
        <name evidence="11 12" type="ordered locus">CAGL0D04356g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445604.1">
        <property type="nucleotide sequence ID" value="XM_445604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVZ0"/>
    <dbReference type="FunCoup" id="Q6FVZ0">
        <property type="interactions" value="1332"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVZ0"/>
    <dbReference type="GeneID" id="2886978"/>
    <dbReference type="KEGG" id="cgr:2886978"/>
    <dbReference type="CGD" id="CAL0128529">
        <property type="gene designation" value="GCV1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D04356g"/>
    <dbReference type="eggNOG" id="KOG2770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_0_1"/>
    <dbReference type="InParanoid" id="Q6FVZ0"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001567">
        <property type="entry name" value="PRK00389.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="18"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="315"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0128529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="391" mass="43066" checksum="E8CDBA8AB784AE65" modified="2004-07-19" version="1">MSLVLKRFNSTALKKTALHDLHVSLGGTMVEFAGYSMPVLYKGQTHIESHLWTRQNAGLFDVSHMLQSRLTGAEATKLLHSVTPTDFANLPQGTGSLSVLLNEHGGVVDDTIITKEQDNQYYIVTNAGCVDRDTEFLKGEVSKLDCSWDIIQGRSLLALQGPKAQQVLERLVTRDSKLNELYFGERKEFTLDDATATRIGVARGGYTGEDGFEISVENGKANEFAQKLLDNELTKPIGLAARDSLRLEAGMCLYGHELTESITPVEAGLAWVISKSRRDAGSEDQFNGYSKIIDQLKNKTHEIIRIAYKYKGKGPAARPGAKIFLEDGETQIGEVTSGSAAPSLNNINIGQGYVKRAHNKKGKTVLIQVRNKFYPAELAKMPLVQTHYHKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW58</accession>
    <name>Q6FW58_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="12">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0D02772g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="12"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW58"/>
    <dbReference type="FunCoup" id="Q6FW58">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW58"/>
    <dbReference type="KEGG" id="cgr:2887224"/>
    <dbReference type="CGD" id="CAL0128293">
        <property type="gene designation" value="CAGL0D02772g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02772g"/>
    <dbReference type="eggNOG" id="KOG0289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023894_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW58"/>
    <dbReference type="OMA" id="MIAYSNE"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0128293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="533" mass="59765" checksum="0E7FA949883C91B3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWK4</accession>
    <name>Q6FWK4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ADO1</name>
        <name evidence="13 14" type="ordered locus">CAGL0C04983g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445390.1">
        <property type="nucleotide sequence ID" value="XM_445390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWK4"/>
    <dbReference type="FunCoup" id="Q6FWK4">
        <property type="interactions" value="1357"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWK4"/>
    <dbReference type="GeneID" id="2886918"/>
    <dbReference type="KEGG" id="cgr:2886918"/>
    <dbReference type="CGD" id="CAL0127176">
        <property type="gene designation" value="ADO1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04983g"/>
    <dbReference type="eggNOG" id="KOG2854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045832_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FWK4"/>
    <dbReference type="OMA" id="RTMCTYL"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="46"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0127176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG58296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="338" mass="36272" checksum="837B088DC6E794CE" modified="2004-07-19" version="1">MSPSLICLCNPLLDIQATVNDDYLKKYNLNANDAVLLETGSTDPRFAIYEELPTFPDVKYVAGGAGQNTARGSAYVLGKGQVGYFGSVGEDKYSKKLLEENEAAGVISLYQVQKDISTGKCAALITGHNRSLVTDLGAANHFKPEHLDKHWDQVTGAKMFYIGGFHLTVSPDAIVKIGQHAKETGKPVVLNLSAPFIPQFFKDALVKVLPYVTIVVANESEAASYAEAFGLTCDKTDLVAIAKEIIGDSSEKKVVFTHGLEPTVLVTKDSDKSFPVKPLDSSKIVDTNGAGDAFAGGFMAGLVQGKSLEQSIDMGQWLAALSIQEVGPSYPKEKIEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWK7</accession>
    <name>Q6FWK7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Carbamoyl phosphate synthase arginine-specific large chain</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26 27" type="ordered locus">CAGL0C04917g</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">Large subunit of the arginine-specific carbamoyl phosphate synthase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, hydrogencarbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The large subunit (synthetase) binds the substrates ammonia (free or transferred from glutamine from the small subunit), hydrogencarbonate and ATP and carries out an ATP-coupled ligase reaction, activating hydrogencarbonate by forming carboxy phosphate which reacts with ammonia to form carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWK7"/>
    <dbReference type="FunCoup" id="Q6FWK7">
        <property type="interactions" value="483"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWK7"/>
    <dbReference type="KEGG" id="cgr:2886783"/>
    <dbReference type="CGD" id="CAL0127438">
        <property type="gene designation" value="CAGL0C04917g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04917g"/>
    <dbReference type="eggNOG" id="KOG0370">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_3_1"/>
    <dbReference type="InParanoid" id="Q6FWK7"/>
    <dbReference type="OMA" id="FPFNKFP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="24">
        <location>
            <begin position="153"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="24">
        <location>
            <begin position="698"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="25">
        <location>
            <begin position="959"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00058046"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="CGD" id="CAL0127438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CAG58293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
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        </source>
    </evidence>
    <sequence length="1113" mass="123126" checksum="ED43F94649707CD4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX40</accession>
    <name>Q6FX40_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0C00517g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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    <dbReference type="InParanoid" id="Q6FX40"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    </dbReference>
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            <end position="291"/>
        </location>
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        <location>
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            <end position="842"/>
        </location>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
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            <dbReference type="Pfam" id="PF17286"/>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG58108.1"/>
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        <source>
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    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX93</accession>
    <name>Q6FX93_CANGA</name>
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        <recommendedName>
            <fullName evidence="8">Glucose-induced degradation protein 7</fullName>
        </recommendedName>
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        <name evidence="5 6" type="ordered locus">CAGL0B00748g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
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            <taxon>Saccharomycetes</taxon>
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            <taxon>Saccharomycetaceae</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
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                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="LisH"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="728"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="784"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="469"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0127724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG57903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="91955" checksum="A67AA02B3EFBC50F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXN6</accession>
    <name>Q6FXN6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">OLA1</name>
        <name evidence="7 8" type="ordered locus">CAGL0B04345g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445159.1">
        <property type="nucleotide sequence ID" value="XM_445159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXN6"/>
    <dbReference type="FunCoup" id="Q6FXN6">
        <property type="interactions" value="1096"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXN6"/>
    <dbReference type="GeneID" id="2886656"/>
    <dbReference type="KEGG" id="cgr:2886656"/>
    <dbReference type="CGD" id="CAL0127040">
        <property type="gene designation" value="CAGL0B04345g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04345g"/>
    <dbReference type="eggNOG" id="KOG1491">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FXN6"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900036">
        <property type="term" value="P:positive regulation of cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="21"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="305"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0127040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="393" mass="43953" checksum="7338C59034C2AC4B" modified="2004-07-19" version="1">MPPKKQVEEKKVLLGRPGNNLKAGIVGLANVGKSTFFQAITRSPLGNPANYPFATIDPEEARVIVPSPRFDELVNIYKPASEVPAHLTVYDIAGLTKGASAGEGLGNAFLSHIRAVDSIYQVVRCFDDAEIIHIEGDVDPVRDLEIISTELRLKDIEFSQKALEAAEKIAKRGGQSLEVKQKKEEMALIERIIKLLEDGQRVYNQTWTPKEVEVINSLYLLTAKPTIYLINLSERDYIRKKNKHLLRIKEWVDKYSPGDLIIPFSVSLEEKLSHMSIEEGEEELKQLGTTSALPKIITTMRQKLDLISFFTCGPDEVREWTIRNGTKAPQAAGVIHNDLMNTFILAQVMKYSDVIEYKDDNAIKAAGKLLQKGKDYVVEDGDVIYFRAGAGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXQ2</accession>
    <name>Q6FXQ2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0B03971g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445143.1">
        <property type="nucleotide sequence ID" value="XM_445143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXQ2"/>
    <dbReference type="FunCoup" id="Q6FXQ2">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXQ2"/>
    <dbReference type="KEGG" id="cgr:2886567"/>
    <dbReference type="CGD" id="CAL0127784">
        <property type="gene designation" value="CAGL0B03971g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03971g"/>
    <dbReference type="eggNOG" id="ENOG502QUA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020178_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FXQ2"/>
    <dbReference type="OMA" id="WTMVNLR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="130"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0127784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="543" mass="61969" checksum="A55DA88F745952D2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY14</accession>
    <name>Q6FY14_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">SED5-binding protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0A01848g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG57739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FY14">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY14"/>
    <dbReference type="KEGG" id="cgr:2886459"/>
    <dbReference type="CGD" id="CAL0126605">
        <property type="gene designation" value="CAGL0A01848g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01848g"/>
    <dbReference type="eggNOG" id="KOG1984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004589_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FY14"/>
    <dbReference type="OMA" id="RLCKHGD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="10">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="11">
        <location>
            <begin position="300"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="13">
        <location>
            <begin position="541"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="12">
        <location>
            <begin position="636"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="9">
        <location>
            <begin position="776"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0126605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG57739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="934" mass="104761" checksum="072B9F50D9C34E7A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY18</accession>
    <name>Q6FY18_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0A01760g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY18"/>
    <dbReference type="STRING" id="284593.Q6FY18"/>
    <dbReference type="KEGG" id="cgr:2886306"/>
    <dbReference type="CGD" id="CAL0126669">
        <property type="gene designation" value="CAGL0A01760g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01760g"/>
    <dbReference type="eggNOG" id="KOG1195">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_6_2_1"/>
    <dbReference type="InParanoid" id="Q6FY18"/>
    <dbReference type="OMA" id="VANRWAI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="12">
        <location>
            <begin position="33"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="11">
        <location>
            <begin position="488"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0126669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG57735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="605" mass="69154" checksum="CFAC7A9FE3072025" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY38</accession>
    <name>Q6FY38_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0A02299g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444864.1">
        <property type="nucleotide sequence ID" value="XM_444864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY38"/>
    <dbReference type="FunCoup" id="Q6FY38">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY38"/>
    <dbReference type="KEGG" id="cgr:2886276"/>
    <dbReference type="CGD" id="CAL0126895">
        <property type="gene designation" value="CAGL0A02299g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02299g"/>
    <dbReference type="HOGENOM" id="CLU_070145_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY38"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274961" description="Secreted protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0126895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG57757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31118" checksum="E11B86BB56DDDF42" modified="2004-07-19" version="1">MSALNGRAYVPKFALKLVCLLLCFELVSIVSAMGGIPTGLPEPQLQNNLDVDDSDNLVTIPDEGNFHDYIEKYAGKNTPLLDKRSGNLIVDIKKVKDASDSSSIQPHTTKVYSKNKKTHTFKVMSLNSTEEVWSDWFPVSKCDIGLGDNDNQIKLKYAYHYNWTKEDTLDADFKHIKSLLKLPISKEVGIGNTFKCGAEAGQTVQVWLQQRCIKALIQTQECTKESSRVIKCNDWDNGTYIMAPLKGIGNVQFGCSGTDNHTECDAKMDPKLGKKFKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY98</accession>
    <name>Q6FY98_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0A03927g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY98"/>
    <dbReference type="FunCoup" id="Q6FY98">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY98"/>
    <dbReference type="KEGG" id="cgr:2886399"/>
    <dbReference type="CGD" id="CAL0126721">
        <property type="gene designation" value="CAGL0A03927g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A03927g"/>
    <dbReference type="eggNOG" id="ENOG502QQBW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033072_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY98"/>
    <dbReference type="OMA" id="CSEEHWA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="2">
        <location>
            <begin position="71"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0126721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG57830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="437" mass="50579" checksum="8AB722C78C2EFC22" modified="2004-07-19" version="1">MIRTRTRAVQNTGKFYACVSKRQLMGFVRNALGLDPPPSPDEPTEQNRFHPWDQSPAVDLRERAARIKTLAKCPVTHKPIQYTCPISGIPTHHSREAWEQDKEYHASKKYEILKKVNIYEHDLRSGRPFPEFDFPRDQGPDRTVNLTNWDLFLYTRSFYSMDTEFQLAAVTKMLSYPITIGSVLHQFSPYSLNPKGPITLEGLKSLAALRYTLYPLQNRAVTTTAKNKPMRIFILGARAEAQLPGHVWKQLQFLFPQQNFEIHFIGPESLYDRERNEYIRSATANGETAADGTTSSIPVTKRIDETMKFFYHTDYFHTLHTAQDFFPYDPYQDVFFMFHPGLASPESKDTWMKDTVKGLLDTKCAIFTTGFNKKDMADDIQILQDTYGKEMDMLMNPVKNVFGSTKWELDDSDPHSVYQFNMYIAGFRGKRYHPIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN27</accession>
    <name>B4UN27_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein transport protein YOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0J03245g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAR58043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN27"/>
    <dbReference type="FunCoup" id="B4UN27">
        <property type="interactions" value="272"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UN27"/>
    <dbReference type="KEGG" id="cgr:9488020"/>
    <dbReference type="CGD" id="CAL0129873">
        <property type="gene designation" value="CAGL0J03245g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03245g"/>
    <dbReference type="eggNOG" id="KOG4779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152125_0_1_1"/>
    <dbReference type="InParanoid" id="B4UN27"/>
    <dbReference type="OMA" id="VQTVMRM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002824257" description="Protein transport protein YOS1" evidence="8">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0129873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAR58043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10225" checksum="5992911B50DDEBB1" modified="2008-09-23" version="1">MIFGLGRLFYVTLLLINAVAVLSEERFLSRIGLGRSGSEAPAFGQNANSTKSKVVQLIGAVQTLLRNRTMQELTHSVPLIGINILVIVYELLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-31" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F2Z613</accession>
    <name>F2Z613_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GAS2</name>
        <name evidence="15 16" type="ordered locus">CAGL0M13849g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Lipid-anchor</topology>
            <topology evidence="1 11">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F2Z613"/>
    <dbReference type="FunCoup" id="F2Z613">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="284593.F2Z613"/>
    <dbReference type="CAZy" id="CBM43">
        <property type="family name" value="Carbohydrate-Binding Module Family 43"/>
    </dbReference>
    <dbReference type="CAZy" id="GH72">
        <property type="family name" value="Glycoside Hydrolase Family 72"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891237"/>
    <dbReference type="CGD" id="CAL0137357">
        <property type="gene designation" value="GAS2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13849g"/>
    <dbReference type="eggNOG" id="ENOG502QPST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021855_2_1_1"/>
    <dbReference type="InParanoid" id="F2Z613"/>
    <dbReference type="OMA" id="QDHTECM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000005">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005129424" description="1,3-beta-glucanosyltransferase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="14">
        <location>
            <begin position="377"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="483"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="483"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0137357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG62926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="565" mass="60396" checksum="11EEEBBA1F376302" modified="2011-05-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-31" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>F2Z6J1</accession>
    <name>F2Z6J1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0C04213g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445359.1">
        <property type="nucleotide sequence ID" value="XM_445359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F2Z6J1"/>
    <dbReference type="KEGG" id="cgr:2886792"/>
    <dbReference type="CGD" id="CAL0127498">
        <property type="gene designation" value="CAGL0C04213g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04213g"/>
    <dbReference type="HOGENOM" id="CLU_1199656_0_0_1"/>
    <dbReference type="InParanoid" id="F2Z6J1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="231" mass="25965" checksum="86FFDE4AE6A17390" modified="2011-05-31" version="1">MLIKRGHQQLCDALFGAESKGLGGNSSDMSNITLAEENIIVAQEPEKLIISNSGLMFLNASTDCYQLGTCEDRKYPKQNIELSKPITWVKISGTFAGILLLGFIIALAIKLNMERQRIKHFRGSGDISIITRDDPESLPLRERYRESMENQPVPQYTRTAGENSNDLGYYDSNGMFHFKQGRQNRPDDSIPGILRRNIAIPNYGPLNDNEVEVYLHAPPPTYQPTYQLSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIL2</accession>
    <name>Q6FIL2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0M13541g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIL2"/>
    <dbReference type="FunCoup" id="Q6FIL2">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIL2"/>
    <dbReference type="KEGG" id="cgr:2891223"/>
    <dbReference type="CGD" id="CAL0136731">
        <property type="gene designation" value="CAGL0M13541g"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_465513_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIL2"/>
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        <property type="component" value="Chromosome M"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of cellular response to glucose starvation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aur-like"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="48"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="547"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="547"/>
            <end position="577"/>
        </location>
    </feature>
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        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
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        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
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        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
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            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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        <source>
            <dbReference type="CGD" id="CAL0136731"/>
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        <source>
            <dbReference type="EMBL" id="CAG62912.1"/>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="622" mass="69673" checksum="AEFE7179B9AD74F2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIR7</accession>
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        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="9 10" type="ordered locus">CAGL0M12298g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
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            <taxon>Saccharomycetes</taxon>
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            <taxon>Saccharomycetaceae</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
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            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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    <dbReference type="OMA" id="CANENII"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF29">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
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    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="141"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="93"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="133"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0136757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="994" mass="113171" checksum="C1A012DDC5D522DC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ15</accession>
    <name>Q6FJ15_CANGA</name>
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        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8 9" type="ordered locus">CAGL0M09955g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ15"/>
    <dbReference type="STRING" id="284593.Q6FJ15"/>
    <dbReference type="KEGG" id="cgr:2891343"/>
    <dbReference type="CGD" id="CAL0137247">
        <property type="gene designation" value="CAGL0M09955g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09955g"/>
    <dbReference type="eggNOG" id="KOG4124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013026_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJ15"/>
    <dbReference type="OMA" id="QPIDITY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001987">
        <property type="entry name" value="Transcription factor SFP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051580">
        <property type="entry name" value="ZnF-Chromatin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23057:SF0">
        <property type="entry name" value="JUXTAPOSED WITH ANOTHER ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="463" mass="51424" checksum="1E7AD8BCB2208D0F" modified="2004-07-19" version="1">MEYNSLMMDAHDVGEYEMGDAFKATHLNVKDGGGQRMSYSVSPSSRPLMTAGEEVVHHIPTRGPSDAQAARLRRDSIAHSQGIGGVSWGSLSISSWLRDEVMLQHPSSQQSYQNQERKFSINNGLLQIQMNAPIGQGPISASTNTFLPHLEEQYCKDYSCCGISLPGLHDLLRHYEEAHISTSPGTSMSRPVGGSDASMGMSTGTVQTRNLMDRSMGSHGMSPPTPMSSQSKIGSNTSINMHQISGANNNNNIKSKYMVNRGHNSNNIVDTVSTNEVFLNNGRGTTSMETSRGTQPIHKHAHPQALQNMMMPPNNGSTQGLHSSNVDIAIDDDDDDEDDDDDDEDDEEEEEQDKKEFYIDDPARRLYVMDHEEYKPFKCPVIGCDKTYKNQNGLKYHRLHGHQNQTLRENADGTFSVIDPESNEVSTLDAMGNDKDKPYRCEVCGKRYKNLNGLKYHRGHSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ24</accession>
    <name>Q6FJ24_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M09757g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCNDBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449770.1">
        <property type="nucleotide sequence ID" value="XM_449770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ24"/>
    <dbReference type="FunCoup" id="Q6FJ24">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ24"/>
    <dbReference type="KEGG" id="cgr:2891334"/>
    <dbReference type="CGD" id="CAL0136317">
        <property type="gene designation" value="CAGL0M09757g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09757g"/>
    <dbReference type="eggNOG" id="ENOG502QZAU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067849_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ24"/>
    <dbReference type="OMA" id="WIDTWEI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.10">
        <property type="entry name" value="Talin, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049318">
        <property type="entry name" value="GCIP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20936">
        <property type="entry name" value="GCIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="7">
        <location>
            <begin position="49"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like C-terminal" evidence="8">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="353" mass="39506" checksum="DB0ADCC245654220" modified="2004-07-19" version="1">MGEEVTFAELKELAGSIKEQFVDPYKNDIGALKKISSETKLQGSDPLTELEKLAKILKAYSTKLGIICEPSKLHGNYHAAYTELKNYADSLFYLLSLLPLFTREQGKLYASYLNEDVFTQVLGLLNGTEMLCDEICSSSKENEGDNKDRLISVGIIWASCDELCDIVKGGNYGLLSKRIALSCGLVDDVLEDIHGWLEDPQLEGADDFLGDDLDSIDELEDGVKKMGIDGDDEEMIEIVKKFLSEWQTKIKMIKLLLSSFSKSITLTTGKNIPNLGSKLDELNKLHKQVILHLDELVSDVFMSGAAFDEDEMGPSIADLNDTLAKMVHIIKEISKQDPKKSKWIDVWNNKYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ58</accession>
    <name>Q6FJ58_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M08976g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ58"/>
    <dbReference type="FunCoup" id="Q6FJ58">
        <property type="interactions" value="807"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ58"/>
    <dbReference type="KEGG" id="cgr:2891297"/>
    <dbReference type="CGD" id="CAL0136849">
        <property type="gene designation" value="CAGL0M08976g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08976g"/>
    <dbReference type="eggNOG" id="KOG2769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015750_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ58"/>
    <dbReference type="OMA" id="CVMHPRF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="41"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="316"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="456" mass="53190" checksum="2FD1BACB9321DBAE" modified="2004-07-19" version="1">MPPKNTTSRKPRSGRGLDVELHPALASSNANIIKAQQKQVNPYLSDIGQQNGKVFKKYKDGLRFYKKGEISAQLHKEREELARRLKEEELRAAAEKAHRVSLAEQKRERIANAEIPDDSIGEELYMQRFKDIPNYEWWDESYLDKSGNILPKYTTEYPEDMDSDYDSDDMNSGVECMKSQTEETGPPSIRYVQHPVPIKIPEEITAPKMYLTKLEHKKARRRNRKLQREEKMAKVQLGLEPKPETKVKLSNMMNVLDNNKNISDPTAWENMVKDQIEERRQRHIQENEKRHEEAVLRKKSKVSDQIEGSEDLFCKAFYFQSLQNPKIRYKLKMNSQQLNLKGFCLRVGEGGPGIIVVIGKEKSCNFYKKLVCTRIKWNENFKIKDATNNGELIDMTGNYAVEIWDGLLKETKLRNWFMKICQTEDEMKNILQQNDALSFFNLFIENKAENTNLSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJC8</accession>
    <name>Q6FJC8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyl phosphorylinositol ceramide synthase SUR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M07315g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJC8"/>
    <dbReference type="CAZy" id="GT32">
        <property type="family name" value="Glycosyltransferase Family 32"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891715"/>
    <dbReference type="CGD" id="CAL0136283">
        <property type="gene designation" value="CAGL0M07315g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07315g"/>
    <dbReference type="eggNOG" id="ENOG502QS3D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036369_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FJC8"/>
    <dbReference type="OMA" id="SSWHTED"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="42706" checksum="8E928F0BAB8C6D96" modified="2004-07-19" version="1">MKREVAYLAITNAFLVFFILFYTFDLLTLCIDDTIHDTLTASDLNSSVPREDELIPRIIHQTYKTEDIPKHWIEGQHRCQELHSDYQYIMWTDQMALDFITEHYSWFLPTFVGYKRPIQRADAIRYFILYHYGGIYIDLDDKCERPLDNLLKLPAFVRKTSPLGISNDVMGSMPGHPFFWKAIHNLNHYNKNWYVPYLTIMSSTGPLFISIVWKHYRRWKIFTKNYVPVKIIQPQDYKGSSSSFFSIVKGSSWHTDDAKWMKSLENHILSCVVAGFIFAFFILYGEYIFYCWLCYKKPITLTNSDSGSKNSWSSKLLWVWNRIKFRSSSYTTTYPTTPTTSPKRSRKDSNAVFDIEKRTVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJD9</accession>
    <name>Q6FJD9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1 6">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M07073g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 6"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJD9"/>
    <dbReference type="FunCoup" id="Q6FJD9">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJD9"/>
    <dbReference type="KEGG" id="cgr:2891704"/>
    <dbReference type="CGD" id="CAL0137387">
        <property type="gene designation" value="CAGL0M07073g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07073g"/>
    <dbReference type="eggNOG" id="KOG2255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FJD9"/>
    <dbReference type="OMA" id="HDELQVP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="196" mass="22542" checksum="1A31A5207B97866E" modified="2004-07-19" version="1">MKLEKSIKYGRAMNKARHLCLTGIGNPEPSYKGTRHNVGLTVLDLLIKQLVPRDQHVFRREGKVHVLRTPTITFIRSDIGFMNLSGRSVVPMWQKLYTDHTDYAVIHDELSLRTGALQLRQPQASLRGHNGLRDISAHWRHQYYKLAIGIDRPESRDPQAVADYVLSKVPQRDATYIENTTTSKALELLQRQFPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJG0</accession>
    <name>Q6FJG0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M06589g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJG0"/>
    <dbReference type="FunCoup" id="Q6FJG0">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJG0"/>
    <dbReference type="KEGG" id="cgr:2891682"/>
    <dbReference type="CGD" id="CAL0136943">
        <property type="gene designation" value="CAGL0M06589g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06589g"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021278_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FJG0"/>
    <dbReference type="OMA" id="EPICINI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="225" mass="25909" checksum="1409C3CF70F05852" modified="2004-07-19" version="1">MDKRILLLIGGGHDTGVKSMSNELKTKFDSLFPESNIKVIDIDYEQEYMISPARIKRSYSNEDYDFDVLYNTLTHQSEHKAEGEVDIIIVCGCYALYNQKINELANLRVFVESDGDVRLINKIRSENIDNSEQLATTLQEYLQNLRPEMENYIEPTRVHAHLIIPYANKDSGVAIIVDGMVKIVNEVSNSRSPDRQNSKEIARNQLYDFLGESMDNERSRYYDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJH8</accession>
    <name>Q6FJH8_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0M06193g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJH8"/>
    <dbReference type="FunCoup" id="Q6FJH8">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJH8"/>
    <dbReference type="KEGG" id="cgr:2891664"/>
    <dbReference type="CGD" id="CAL0137213">
        <property type="gene designation" value="CAGL0M06193g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06193g"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_57_1_1"/>
    <dbReference type="InParanoid" id="Q6FJH8"/>
    <dbReference type="OMA" id="NYALKCT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903341">
        <property type="term" value="P:regulation of meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0137213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="316" mass="34827" checksum="76F7D8FD27E76923" modified="2004-07-19" version="1">MMEVLKQIEIPGGGPSTCGVFSRDGQWLAVVRGIEVYIYETSGYQLRETLVLEHAAGVSQICWSPDGKCIASCSDDFTVVVTHRQLGLLHRLVGHTAPVISLCYNNKGNLLFTSSMDESIKVWDVLTGTVMKTMSAHSEPVVSIDLSDNDGSILSSGSHDGLIRIFDTATGHCLKTLTYDKDWQSETGVVPIAKVKFSANTKYLLVKSYDGVVKIWDSVSGDVVRTFKPSNKKYNLTHCCGMDFMYPQSTQSPLILSGYEKGEIYCWDSNTKAELQVLKIEECDSAIISIDCHNNLMCSLSLAGNCTIWKYVTETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJQ1</accession>
    <name>Q6FJQ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M04499g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJQ1"/>
    <dbReference type="FunCoup" id="Q6FJQ1">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJQ1"/>
    <dbReference type="KEGG" id="cgr:2891552"/>
    <dbReference type="CGD" id="CAL0137033">
        <property type="gene designation" value="CAGL0M04499g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04499g"/>
    <dbReference type="eggNOG" id="KOG0186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029274_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJQ1"/>
    <dbReference type="OMA" id="IIKYVPW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000017">
        <property type="entry name" value="Proline dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF0">
        <property type="entry name" value="PROLINE DEHYDROGENASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="204"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0137033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="469" mass="52426" checksum="889D68A9FF657789" modified="2004-07-19" version="1">MLRIYRPRVMAIARRYVSQTAQTSNAMVADTTDPMMNPMQPKLSSHSQLPPSSVAYLKTLSRAEVFSLGMIGLATTSKPVLNLVIKLFPYVPMPLIKMFVSRLYCGGDNINEVKTFGEKLQKRGISNMMLSLTIEDSEGTKNIDINYIVEETIKSVHGVLKPNLVNQLEKCGNDAKKINEIAPGYIALKPSALVSNPHDVLMNFNNPDPHWVAQREKLIDNCSRIAQEIYDLNNDLLKKYPSRTAPFCVATIDAEKYDLQNSGVYELQRILFQKFNKLSSPMVSVIGTWQLYLVDSAAQLAREHARAMKEGYKLGVKLVRGAYIHSETKRDSIIFKTKEGTDENYDAVMTTVIQDLLKNGTKSYYGHLVVASHNYGSQMLATKILKDAPENVGKANIVLGQLLGMSDNVTHDLITKHGAKNIIKYVPWGPPLETKDYLLRRLQENGDAVKSDNGFPLVKAVIKSLFSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJS8</accession>
    <name>Q6FJS8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kri1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0M03905g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJS8"/>
    <dbReference type="FunCoup" id="Q6FJS8">
        <property type="interactions" value="695"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJS8"/>
    <dbReference type="KEGG" id="cgr:2891525"/>
    <dbReference type="CGD" id="CAL0136923">
        <property type="gene designation" value="CAGL0M03905g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03905g"/>
    <dbReference type="eggNOG" id="KOG2409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009647_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FJS8"/>
    <dbReference type="OMA" id="KIMATRH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="444"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="275"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="550"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0136923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="586" mass="68593" checksum="C56511615A77B370" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKE4</accession>
    <name>Q6FKE4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI transamidase component GAA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L12232g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKE4"/>
    <dbReference type="FunCoup" id="Q6FKE4">
        <property type="interactions" value="623"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKE4"/>
    <dbReference type="KEGG" id="cgr:2890690"/>
    <dbReference type="CGD" id="CAL0134980">
        <property type="gene designation" value="CAGL0L12232g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12232g"/>
    <dbReference type="eggNOG" id="KOG3566">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007442_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FKE4"/>
    <dbReference type="OMA" id="RESEWNI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036762">
        <property type="entry name" value="GAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="66691" checksum="AA8DC3A3CA885CA0" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKI9</accession>
    <name>Q6FKI9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent DNA helicase PIF1</fullName>
            <ecNumber evidence="16">5.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">DNA 5'-3' helicase PIF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">DNA repair and recombination helicase PIF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PIF1</name>
        <name evidence="19 20" type="ordered locus">CAGL0L11198g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Involved in the maintenance of ribosomal (rDNA). Required for efficient fork arrest at the replicaion fork barrier within rDNA. Involved in the maintenance of mitochondrial (mtDNA). Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks. May inhibit replication progression to allow time for repair. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer. Interacts with telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the helicase family. PIF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="16"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449255.1">
        <property type="nucleotide sequence ID" value="XM_449255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKI9"/>
    <dbReference type="FunCoup" id="Q6FKI9">
        <property type="interactions" value="860"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKI9"/>
    <dbReference type="GeneID" id="2891030"/>
    <dbReference type="KEGG" id="cgr:2891030"/>
    <dbReference type="CGD" id="CAL0135186">
        <property type="gene designation" value="CAGL0L11198g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11198g"/>
    <dbReference type="eggNOG" id="KOG0987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001613_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKI9"/>
    <dbReference type="OMA" id="FAFESKA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033678">
        <property type="term" value="F:5'-3' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061995">
        <property type="term" value="F:ATP-dependent protein-DNA complex displacement activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="PIF1_helicase"/>
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        <property type="entry name" value="PIF1_RRM3_pfh1"/>
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        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE"/>
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        <property type="entry name" value="Pif1_2B_dom"/>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="5 16" id="KW-0227">DNA damage</keyword>
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    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10 16" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
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    <feature type="DNA-binding region" evidence="16">
        <location>
            <begin position="745"/>
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            <begin position="799"/>
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        <ligand>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="841" mass="95238" checksum="0B79FC76DBF82337" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKZ1</accession>
    <name>Q6FKZ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0L07480g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAG62073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_449103.1"/>
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    <dbReference type="STRING" id="284593.Q6FKZ1"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07480g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_885654_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKZ1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="280"/>
            <end position="309"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0135396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62073.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="314" mass="34687" checksum="726F41A03FD242E9" modified="2004-07-19" version="1">MYLTAPMYSPSATSTMNIQKVVSQLNVNEQNNILLPSLATCGTHLKSNTDDDMKLLLNKFAFHNSNYFLQPTIHTSNSSSASSTAVSSPVVAPMLQNSLPSPSLSPQQFKLDSESPNNIVPPKIVVEEADQIQESPKPKRVKRRTKSASSMKKAPIKVVFDSSNSHNMSTEAIVNGVPSPATSPKPKRKNSTGTMSRSPFKTFNGCLNVNGKQDKKVLLGHISKPSNKVYSNRSSVIKLKDNTQKIEQRRKHICQICLTGFTTSGHLSRHAKIHTGEKSHVCPHEGCNQSFSRHDNCLQHYRTHSKKKEQSQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL10</accession>
    <name>Q6FL10_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RRM Nup35-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0L07062g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL10"/>
    <dbReference type="FunCoup" id="Q6FL10">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL10"/>
    <dbReference type="DNASU" id="2890829"/>
    <dbReference type="KEGG" id="cgr:2890829"/>
    <dbReference type="CGD" id="CAL0135240">
        <property type="gene designation" value="CAGL0L07062g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07062g"/>
    <dbReference type="eggNOG" id="ENOG502QWFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024892_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL10"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031990">
        <property type="term" value="P:mRNA export from nucleus in response to heat stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12721">
        <property type="entry name" value="RRM_Nup53p_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007846">
        <property type="entry name" value="RRM_NUP35_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21527:SF6">
        <property type="entry name" value="NUCLEOPORIN NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05172">
        <property type="entry name" value="RRM_Nup35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51472">
        <property type="entry name" value="RRM_NUP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6 8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM Nup35-type" evidence="9">
        <location>
            <begin position="233"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0135240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="486" mass="53921" checksum="667653DFDAD33DC8" modified="2004-07-19" version="1">MTASVKQDRFSNVNLLYSIQDKYQTNQDQSFHSNQSNLSTTGNYNALKSLSMLPPPSMGMATNSDVGTKNDMGSVSWYNNPKKKSNLHNNLSKRSLLLRSTGNENKSETSSGIHLKNNGFNLADFSKKDSSDLLQKKDNLGATDIYNSTTDYPPTTSLHDWQREDEFGIVQTASNTSNYGEPNSKSYHNNSYGGLIKTPNVFDKSGQSSGYKLSSTIGKNNTDVNKNDNNSAIYSESAVIVFGYPEYLSNQVITHFSHFGNILEDFEILRSSTGINNNTFRLHANLNALQEGSMSTKLPIFTGEGWVKITYDSPTSALRALKENGTVFTGHLIGCIPYSKSAVEQLALISVDKSDDIGSIDLGQINKSVNEDSRNKGSNGKVYPSLGSVDHIEPINGRQKEANMKSFGTPIINNNQQYLDHSIMAHPRHKLDIQDGKSLFVHNSSHHKTQFLDNIEKKIKEKEANKNESGSWSGRLTNWVFGWDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL20</accession>
    <name>Q6FL20_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">THI3</name>
        <name evidence="14 15" type="ordered locus">CAGL0L06842g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449074.1">
        <property type="nucleotide sequence ID" value="XM_449074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL20"/>
    <dbReference type="FunCoup" id="Q6FL20">
        <property type="interactions" value="372"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL20"/>
    <dbReference type="GeneID" id="2890819"/>
    <dbReference type="KEGG" id="cgr:2890819"/>
    <dbReference type="CGD" id="CAL0135988">
        <property type="gene designation" value="THI3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06842g"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FL20"/>
    <dbReference type="OMA" id="LRQEWVW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071301">
        <property type="term" value="P:cellular response to vitamin B1"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090180">
        <property type="term" value="P:positive regulation of thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070623">
        <property type="term" value="P:regulation of thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="13">
        <location>
            <begin position="15"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="11">
        <location>
            <begin position="212"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="12">
        <location>
            <begin position="416"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0135988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG62044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="71895" checksum="191A0B315D72082E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL31</accession>
    <name>Q6FL31_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NAS6</name>
        <name evidence="4 5" type="ordered locus">CAGL0L06600g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449063.1">
        <property type="nucleotide sequence ID" value="XM_449063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL31"/>
    <dbReference type="FunCoup" id="Q6FL31">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL31"/>
    <dbReference type="GeneID" id="2890662"/>
    <dbReference type="KEGG" id="cgr:2890662"/>
    <dbReference type="CGD" id="CAL0136118">
        <property type="gene designation" value="NAS6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06600g"/>
    <dbReference type="eggNOG" id="KOG4412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_2_1"/>
    <dbReference type="InParanoid" id="Q6FL31"/>
    <dbReference type="OMA" id="WAVAYNR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904855">
        <property type="term" value="F:proteasome regulatory particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0136118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="231" mass="25465" checksum="5AACCA033E1F4957" modified="2004-07-19" version="1">MEFPLHKACLNNEPRKVQELLESSDPFKAVVQRDDDGRVPLHWAVSIQSDAIIKLLLPYMKSVDIDTLTDEAGWTPFHISCSIGHLDIVDQLYNNNPDARPNLDLQTSQGVTALHLAVAKKHLEVCKYLIKLGASVRIKDKKGQIALHRAAAVGSIGVVEFLCSTAKSPVNWKDASGWTPLFHAIAEGHADIAVLLVNKFSADYEVEDSDGKKPIDVAPSESVKEYFSKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL82</accession>
    <name>Q6FL82_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inorganic phosphate transporter PHO86</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PHO86</name>
        <name evidence="2 3" type="ordered locus">CAGL0L05456g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449012.1">
        <property type="nucleotide sequence ID" value="XM_449012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL82"/>
    <dbReference type="FunCoup" id="Q6FL82">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL82"/>
    <dbReference type="GeneID" id="2890791"/>
    <dbReference type="KEGG" id="cgr:2890791"/>
    <dbReference type="CGD" id="CAL0136176">
        <property type="gene designation" value="PHO86"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05456g"/>
    <dbReference type="eggNOG" id="ENOG502QSU5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076919_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL82"/>
    <dbReference type="OMA" id="ELWGVQF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010966">
        <property type="term" value="P:regulation of phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024297">
        <property type="entry name" value="Pho86"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11124">
        <property type="entry name" value="Pho86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34183" checksum="9E305FF7F2F8E514" modified="2004-07-19" version="1">MVGDLRRAVPQIDATLNAPLDKDAPPTIYASSLTPSMATAALNLPADFLKQKQGLANKTLICHPVVISAIGLFLSTYLAIQINVPKNTSSSIAGYLYQIFLMNKKEVITALLFTLIAASFVFTLLSRVSDLYFRAVIDNVVESKGEQLYGVNLNDISVLTKKEVEQKPKEFRENLENTHIIIYRETPIALVSIAKNNVLSTKDSLVMSISTIGSRRVYIRSGIIEDLLDWAMIRTRKIGAAGNYGKSMKIICEIYSFDQDMKKILKSKGFVKVQSARIKENRLLGGLFGIKKELWGVQFHYEKKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLA5</accession>
    <name>Q6FLA5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAGL0L04928g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLA5"/>
    <dbReference type="STRING" id="284593.Q6FLA5"/>
    <dbReference type="MEROPS" id="S59.951"/>
    <dbReference type="DNASU" id="2890713"/>
    <dbReference type="KEGG" id="cgr:2890713"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011051_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLA5"/>
    <dbReference type="OMA" id="PHENGKS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF30">
        <property type="entry name" value="NUCLEOPORIN NUP100_NSP100-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="13">
        <location>
            <begin position="880"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="55"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="114"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="234"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="490"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="811"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="391"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="416"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="534"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="567"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="621"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG61959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1024" mass="105507" checksum="0BE5631570ADCE82" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLC8</accession>
    <name>Q6FLC8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L04400g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
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                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
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        <property type="entry name" value="TRANSCRIPTION FACTOR PDR8-RELATED"/>
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        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0135568"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG61936.1"/>
        </source>
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        </source>
    </evidence>
    <sequence length="987" mass="112705" checksum="F15B008874905F22" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLD9</accession>
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        <recommendedName>
            <fullName evidence="7">Factor arrest protein 11</fullName>
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        <name evidence="4 5" type="ordered locus">CAGL0L04158g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
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        <lineage>
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            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
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                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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    <dbReference type="InParanoid" id="Q6FLD9"/>
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        <property type="component" value="Chromosome L"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:re-entry into mitotic cell cycle after pheromone arrest"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Far11/STRP_N"/>
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        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="213"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="582"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="179"/>
        </location>
    </feature>
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            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0135232"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG61925.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="107358" checksum="6D152F02EFB30911" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
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        <name evidence="3 4" type="ordered locus">CAGL0L03069g</name>
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        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
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            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
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                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FLI9">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLI9"/>
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        <property type="gene designation" value="CAGL0L03069g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03069g"/>
    <dbReference type="eggNOG" id="KOG2845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042447_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLI9"/>
    <dbReference type="OMA" id="MWASPQE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="181"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0135748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="532" mass="61207" checksum="00176F077400B7BE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLL0</accession>
    <name>Q6FLL0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0L02607g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLL0"/>
    <dbReference type="FunCoup" id="Q6FLL0">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLL0"/>
    <dbReference type="KEGG" id="cgr:2890859"/>
    <dbReference type="CGD" id="CAL0135198">
        <property type="gene designation" value="CAGL0L02607g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02607g"/>
    <dbReference type="eggNOG" id="KOG4419">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019028_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLL0"/>
    <dbReference type="OMA" id="QTIGNHE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012723219" evidence="1">
        <location>
            <begin position="16"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="363"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0135198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="585" mass="66446" checksum="C29185EF4C4837C3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLT8</accession>
    <name>Q6FLT8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein SYG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0L00737g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLT8"/>
    <dbReference type="FunCoup" id="Q6FLT8">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLT8"/>
    <dbReference type="KEGG" id="cgr:2890928"/>
    <dbReference type="CGD" id="CAL0135678">
        <property type="gene designation" value="CAGL0L00737g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L00737g"/>
    <dbReference type="eggNOG" id="KOG1162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006116_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FLT8"/>
    <dbReference type="OMA" id="SIPWAHA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14475">
        <property type="entry name" value="SPX_SYG1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF103">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 53 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="8">
        <location>
            <begin position="600"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="885"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="887"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="901"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0135678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="911" mass="105630" checksum="2BA5A9DEF7A9904F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLU2</accession>
    <name>ACS1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Acetyl-coenzyme A synthetase 1</fullName>
            <ecNumber>6.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Acetate--CoA ligase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Acyl-activating enzyme 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ACS1</name>
        <name type="ordered locus">CAGL0L00649g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Microsome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448802.1">
        <property type="nucleotide sequence ID" value="XM_448802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLU2"/>
    <dbReference type="SMR" id="Q6FLU2"/>
    <dbReference type="FunCoup" id="Q6FLU2">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLU2"/>
    <dbReference type="EnsemblFungi" id="CAGL0L00649g-T">
        <property type="protein sequence ID" value="CAGL0L00649g-T-p1"/>
        <property type="gene ID" value="CAGL0L00649g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891117"/>
    <dbReference type="KEGG" id="cgr:2891117"/>
    <dbReference type="CGD" id="CAL0136172">
        <property type="gene designation" value="CAGL0L00649g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L00649g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L00649g"/>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_3_6_1"/>
    <dbReference type="InParanoid" id="Q6FLU2"/>
    <dbReference type="OMA" id="AIKASWP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016880">
        <property type="term" value="F:acid-ammonia (or amide) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019654">
        <property type="term" value="P:acetate fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0492">Microsome</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000208407" description="Acetyl-coenzyme A synthetase 1">
        <location>
            <begin position="1"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Microbody targeting signal" evidence="2">
        <location>
            <begin position="702"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="434"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="458"/>
            <end position="463"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="565"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="704" mass="79263" checksum="9E3D72E57E80536A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLW3</accession>
    <name>Q6FLW3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-mannosyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BMT7</name>
        <name evidence="7 8" type="ordered locus">CAGL0K12980g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BMT family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448781.1">
        <property type="nucleotide sequence ID" value="XM_448781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLW3"/>
    <dbReference type="STRING" id="284593.Q6FLW3"/>
    <dbReference type="CAZy" id="GT91">
        <property type="family name" value="Glycosyltransferase Family 91"/>
    </dbReference>
    <dbReference type="GeneID" id="2890125"/>
    <dbReference type="KEGG" id="cgr:2890125"/>
    <dbReference type="CGD" id="CAL0134123">
        <property type="gene designation" value="BMT7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12980g"/>
    <dbReference type="eggNOG" id="ENOG502QTZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383085_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLW3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021988">
        <property type="entry name" value="BMT1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12141">
        <property type="entry name" value="BMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="83437" checksum="04A6C11CC1D77740" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM23</accession>
    <name>Q6FM23_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial oxaloacetate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0K11616g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria. Exports alpha-isopropylmalate from mitochondrial matrix to the cytosol, where it serves as a precursor for leucine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3S)-3-isopropylmalate(in) + sulfate(out) = (2R,3S)-3-isopropylmalate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:76347"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:76348"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:76349"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2S)-2-isopropylmalate(in) + sulfate(out) = (2S)-2-isopropylmalate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:76343"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:76344"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:76345"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>malonate(in) + sulfate(out) = malonate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73195"/>
            <dbReference type="ChEBI" id="CHEBI:15792"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:73196"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:73197"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>oxaloacetate(in) + sulfate(out) = oxaloacetate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:76351"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:76352"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:76353"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:73215"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:73216"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:73217"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM23"/>
    <dbReference type="FunCoup" id="Q6FM23">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM23"/>
    <dbReference type="KEGG" id="cgr:2890524"/>
    <dbReference type="CGD" id="CAL0134747">
        <property type="gene designation" value="CAGL0K11616g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11616g"/>
    <dbReference type="eggNOG" id="KOG0755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_14_3_1"/>
    <dbReference type="InParanoid" id="Q6FM23"/>
    <dbReference type="OMA" id="GFYDPMR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034658">
        <property type="term" value="F:isopropylmalate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901239">
        <property type="term" value="F:malonate(1-) transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015131">
        <property type="term" value="F:oxaloacetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015116">
        <property type="term" value="F:sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000039">
        <property type="entry name" value="Solute carrier family 25 member 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 18" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="122"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="17">
        <location>
            <begin position="223"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0134747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG61684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="320" mass="34841" checksum="8706DB2BD9E79505" modified="2004-07-19" version="1">MAKGEDKIQKSAAQKVSKFGSFTAGGLAACIAVTVTNPIEVVKIRMQLQGELMAANQRIYTNPFQAMGVVFRNEGIRGLQKGLVAAYIYQIALNGSRLGFYEPIRAVMNKTFYPDQESHKVQSVGINVFAGAASGIIGAVMGSPLFLVKTRLQSYSNAIKIGEQTHYTGVWNGLKTIYMTEGVKGLFRGIDAAILRTGAGSSVQLPIYNTAKNFLLRNDIMEDGPSLHLTASTISGLGVAVVMNPWDVILTRIYNQKGDLYKGPIDCLVKTVKIEGITALYKGFEAQVFRIGPHTILCLTFLEQTMKLVHAFESKVLGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM35</accession>
    <name>Q6FM35_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein IVY1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K11363g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61672.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM35"/>
    <dbReference type="FunCoup" id="Q6FM35">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM35"/>
    <dbReference type="KEGG" id="cgr:2890068"/>
    <dbReference type="CGD" id="CAL0134175">
        <property type="gene designation" value="CAGL0K11363g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11363g"/>
    <dbReference type="eggNOG" id="ENOG502QTA6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034174_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FM35"/>
    <dbReference type="OMA" id="ALENMAH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037470">
        <property type="entry name" value="IVY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407:SF1">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61672.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="46148" checksum="2E4DF6875567A30E" modified="2008-09-23" version="2">MNGKEENFKSPARYAAHLSEFYPLVNGESHGQMSNKEDMHTPDRRSYLEEPITPRSQMHTRRTSSVASGVSSISDIQSFVTKRDVKLTSDALKELHETSYRFSKALNSVATEANAMAKSLESIARLKGCGDDIAQNLLSAGGLFYLVGNHDLIMANYLDEYLGENLLKDIDEFKVDSKTLENSFKAKSKSETVKLRLQEKHNRQLGKRKIRNLLAYRESLLSLQNTLDDLETLKHNYYVDSYELVESTCSKVLGKVASLSRAQLEISENIARKGWAGGGLDNLLQVSDDQYNKDTMETEEEQDNPTAAQPTLTKTQSDNGGRASLSPSQTGLRSPIKAIQEGSIKTNDQSSLLRGDESQDQEAQNSIDRESENNYDVTENSFSLPPTRKDDLEDAGSSENILSGLDKLKIDEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMA8</accession>
    <name>Q6FMA8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="13">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0K09570g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="13"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMA8"/>
    <dbReference type="FunCoup" id="Q6FMA8">
        <property type="interactions" value="572"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMA8"/>
    <dbReference type="KEGG" id="cgr:2890238"/>
    <dbReference type="CGD" id="CAL0134931">
        <property type="gene designation" value="CAGL0K09570g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09570g"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035066_5_2_1"/>
    <dbReference type="InParanoid" id="Q6FMA8"/>
    <dbReference type="OMA" id="RYASGVC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0134931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG61599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="397" mass="45837" checksum="672B616549120694" modified="2004-07-19" version="1">MGYFIPKEAIANLKYYKYQSEDRSLISNYILRPYWRWFSQLFPMWMAPNLVTLSGLGFIILNVLTVLYYDPYLNTETPRWTYFSYALGLFLYQTFDACDGMHARRTGQSSPLGELFDHCIDSLNTTLSLFPVCSMLGCGYSMILIGTQFMVLGNFYLSTWEEFYTHRLFLSEFSGPVEGILLLVFQFILCGLFGTQRVWHTKLLSIHLPLTIGNSDIFELETVHLMICFSTFALLFNILAATSNVFQYFKEHNKKNDMEEVEAEKKEAMIALMPFFIYFATVFALVAVDNLFISFPFIISVGLTMAFVVGRMIVGHLTKQKFPLVNFPMFIPISQLIMYIIFVCYFKSDRETMVLALLWGGFGVSLGIHAMFINEIIYEFTTYLDVYALSIKHPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMF5</accession>
    <name>Q6FMF5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0K08470g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448589.1">
        <property type="nucleotide sequence ID" value="XM_448589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMF5"/>
    <dbReference type="KEGG" id="cgr:2890316"/>
    <dbReference type="CGD" id="CAL0134947">
        <property type="gene designation" value="CAGL0K08470g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08470g"/>
    <dbReference type="HOGENOM" id="CLU_2960536_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMF5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0134947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="59" mass="6524" checksum="0CA1D4B9859154DA" modified="2004-07-19" version="1">MSMFAMGCPDVIQIIQLCGGKSTEGSSYHELIRGYSIACIDVLVSRLLVDICRHSFSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMG2</accession>
    <name>Q6FMG2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0K08294g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FMG2">
        <property type="interactions" value="805"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMG2"/>
    <dbReference type="KEGG" id="cgr:2890350"/>
    <dbReference type="CGD" id="CAL0134815">
        <property type="gene designation" value="CAGL0K08294g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08294g"/>
    <dbReference type="eggNOG" id="KOG3595">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000038_7_0_1"/>
    <dbReference type="InParanoid" id="Q6FMG2"/>
    <dbReference type="OMA" id="NERQMTR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000235">
        <property type="term" value="C:astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902850">
        <property type="term" value="P:microtubule cytoskeleton organization involved in mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000996">
        <property type="entry name" value="Cytoplasmic dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="1781"/>
            <end position="1918"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2056"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="2398"/>
            <end position="2547"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2999"/>
            <end position="3026"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3502"/>
            <end position="3564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0134815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG61545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="4041" mass="468182" checksum="1073571502CE4ED9" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMK5</accession>
    <name>Q6FMK5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0K07293g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMK5"/>
    <dbReference type="FunCoup" id="Q6FMK5">
        <property type="interactions" value="797"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMK5"/>
    <dbReference type="KEGG" id="cgr:2890400"/>
    <dbReference type="CGD" id="CAL0134751">
        <property type="gene designation" value="CAGL0K07293g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07293g"/>
    <dbReference type="eggNOG" id="KOG1180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_2_1"/>
    <dbReference type="InParanoid" id="Q6FMK5"/>
    <dbReference type="OMA" id="RWEPVFH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="86"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="696" mass="77143" checksum="6E101DCD6F7E3CF3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-06-18" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FML6</accession>
    <name>RMD9L_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein RMD9-like, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAGL0K07007g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in the processing or stability of mitochondrial mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated. Phosphorylation promotes binding to RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RMD9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448528.1">
        <property type="nucleotide sequence ID" value="XM_448528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FML6"/>
    <dbReference type="SMR" id="Q6FML6"/>
    <dbReference type="FunCoup" id="Q6FML6">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FML6"/>
    <dbReference type="EnsemblFungi" id="CAGL0K07007g-T">
        <property type="protein sequence ID" value="CAGL0K07007g-T-p1"/>
        <property type="gene ID" value="CAGL0K07007g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890387"/>
    <dbReference type="CGD" id="CAL0134107">
        <property type="gene designation" value="CAGL0K07007g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K07007g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07007g"/>
    <dbReference type="eggNOG" id="ENOG502QUSW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019840_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FML6"/>
    <dbReference type="OMA" id="EMKYGYL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000301789" description="RNA-binding protein RMD9-like, mitochondrial">
        <location>
            <begin position="80"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="566"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P53140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="736" mass="83630" checksum="0DBBFE6A2DA2D30E" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMP9</accession>
    <name>Q6FMP9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TSA1</name>
        <name evidence="13 14" type="ordered locus">CAGL0K06259g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMP9"/>
    <dbReference type="FunCoup" id="Q6FMP9">
        <property type="interactions" value="1079"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMP9"/>
    <dbReference type="PeroxiBase" id="4469">
        <property type="entry name" value="Cgl2CysPrx02"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890460"/>
    <dbReference type="CGD" id="CAL0134717">
        <property type="gene designation" value="TSA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06259g"/>
    <dbReference type="eggNOG" id="KOG0852">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_0_1"/>
    <dbReference type="InParanoid" id="Q6FMP9"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="PHI-base" id="PHI:9714"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="3"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0134717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG61456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="198" mass="21868" checksum="31707FBCD96379BB" modified="2004-07-19" version="1">MVAQVQKPAPTFKKTAVIDGMFEEVSLDKYKGKYVVLAFVPLAFTFVCPTEIVAFSEAAKRFEALDAQVLFASTDSEYSLLAWTNVARKDGGLGPVDIPLLADTNHKLSRDYGVLIEDEGIALRGLFIIDPKGIVRHITINDLPVGRNVEESLRLVEGFQWTDKNGTVLPCNWTPGSATIKPTVEDSKEYFKEANSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMU6</accession>
    <name>Q6FMU6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0K05093g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMU6"/>
    <dbReference type="FunCoup" id="Q6FMU6">
        <property type="interactions" value="1176"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMU6"/>
    <dbReference type="MEROPS" id="M41.004"/>
    <dbReference type="KEGG" id="cgr:2890505"/>
    <dbReference type="CGD" id="CAL0134383">
        <property type="gene designation" value="CAGL0K05093g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05093g"/>
    <dbReference type="eggNOG" id="KOG0734">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_9_3_1"/>
    <dbReference type="InParanoid" id="Q6FMU6"/>
    <dbReference type="OMA" id="MSHFEWA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="310"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="708"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="661"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0134383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG61409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="745" mass="80338" checksum="4B0B1E7AC8A326D8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMV7</accession>
    <name>Q6FMV7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxisomal membrane protein PEX17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PEX17</name>
        <name evidence="2 3" type="ordered locus">CAGL0K04851g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448437.1">
        <property type="nucleotide sequence ID" value="XM_448437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMV7"/>
    <dbReference type="FunCoup" id="Q6FMV7">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMV7"/>
    <dbReference type="GeneID" id="2890016"/>
    <dbReference type="KEGG" id="cgr:2890016"/>
    <dbReference type="CGD" id="CAL0133791">
        <property type="gene designation" value="PEX17"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04851g"/>
    <dbReference type="eggNOG" id="ENOG502S4G6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115007_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMV7"/>
    <dbReference type="OMA" id="REMKGWF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24486" checksum="40B611811C4502B7" modified="2004-07-19" version="1">MAYQESESIQWPDPQRIRNYKARNKTIRTIQSIFSNTGLLFTIFYVAVSTIVQPSLERQYNQRIELTAGALLEVRRLTNKLLRRLKSKNSSELELRSNTQEYADRCTQTESRYITDDFESDDDMHNDSDDNSITWNIISKKLVEVKDSLNRYNESCDRPSINMENLTFQSKLVVDQLSVAKDADKLGELSRTSVNNIREMKGWFVNGLVSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNA2</accession>
    <name>DBP10_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP10</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP10</name>
        <name type="ordered locus">CAGL0K01551g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448292.1">
        <property type="nucleotide sequence ID" value="XM_448292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNA2"/>
    <dbReference type="SMR" id="Q6FNA2"/>
    <dbReference type="FunCoup" id="Q6FNA2">
        <property type="interactions" value="1172"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNA2"/>
    <dbReference type="EnsemblFungi" id="CAGL0K01551g-T">
        <property type="protein sequence ID" value="CAGL0K01551g-T-p1"/>
        <property type="gene ID" value="CAGL0K01551g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890018"/>
    <dbReference type="KEGG" id="cgr:2890018"/>
    <dbReference type="CGD" id="CAL0134057">
        <property type="gene designation" value="CAGL0K01551g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01551g"/>
    <dbReference type="eggNOG" id="KOG0337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FNA2"/>
    <dbReference type="OMA" id="EDQFGMM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000865">
        <property type="entry name" value="ATP-dependent RNA helicase DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232312" description="ATP-dependent RNA helicase DBP10">
        <location>
            <begin position="1"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="146"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="396"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="860"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="946"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="266"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="897"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="958"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="969" mass="109562" checksum="3E2CCA59606C8401" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNA9</accession>
    <name>FAD1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAD synthase</fullName>
            <ecNumber evidence="4 5">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">FMN adenylyltransferase</fullName>
            <shortName evidence="6">FMNAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Flavin adenine dinucleotide synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FMNAT</name>
        <name evidence="7" type="ordered locus">CAGL0K01397g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="J. Mol. Biol." volume="389" first="388" last="400">
            <title>Structure and mechanism of a eukaryotic FMN adenylyltransferase.</title>
            <authorList>
                <person name="Huerta C."/>
                <person name="Borek D."/>
                <person name="Machius M."/>
                <person name="Grishin N.V."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="19375431"/>
            <dbReference type="DOI" id="10.1016/j.jmb.2009.04.022"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.20 ANGSTROMS) IN COMPLEX WITH ATP; FAD; FMN AND MG(2+)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>COFACTOR</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>PATHWAY</scope>
        <scope>SUBUNIT</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="journal article" date="2013" name="Biochemistry" volume="52" first="3615" last="3617">
            <title>The 'super mutant' of yeast FMN adenylyltransferase enhances the enzyme turnover rate by attenuating product inhibition.</title>
            <authorList>
                <person name="Huerta C."/>
                <person name="Grishin N.V."/>
                <person name="Zhang H."/>
            </authorList>
            <dbReference type="PubMed" id="23663086"/>
            <dbReference type="DOI" id="10.1021/bi400454w"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS)</scope>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>PATHWAY</scope>
        <scope>MUTAGENESIS OF ASN-62; ASP-66; ASP-168; ASP-181; TRP-184; ARG-297 AND ARG-300</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5">Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 5">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4 5">
            <dbReference type="Rhea" id="RHEA:17238"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by FAD.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="4">0.76 uM for FMN (at 25 degrees Celsius and at pH 7.5)</KM>
            <KM evidence="5">1 uM for FMN (at 25 degrees Celsius and at pH 7.5)</KM>
            <KM evidence="4">10.7 uM for ATP (at 25 degrees Celsius and at pH 7.5)</KM>
            <KM evidence="5">2 uM for ATP (at 25 degrees Celsius and at pH 7.5)</KM>
            <text evidence="4 5">kcat is 0.087 sec(-1) (at 25 degrees Celsius and at pH 7.5) (PubMed:19375431). kcat is 0.089 sec(-1) (at 25 degrees Celsius and at pH 7.5) (PubMed:23663086).</text>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text evidence="4 5">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PAPS reductase family. FAD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="4 5"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="3FWK">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.20 A"/>
        <property type="chains" value="A=1-304"/>
    </dbReference>
    <dbReference type="PDB" id="3G59">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.87 A"/>
        <property type="chains" value="A=1-304"/>
    </dbReference>
    <dbReference type="PDB" id="3G5A">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-304"/>
    </dbReference>
    <dbReference type="PDB" id="3G6K">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.35 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-304"/>
    </dbReference>
    <dbReference type="PDB" id="4KKV">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.74 A"/>
        <property type="chains" value="A=1-304"/>
    </dbReference>
    <dbReference type="PDBsum" id="3FWK"/>
    <dbReference type="PDBsum" id="3G59"/>
    <dbReference type="PDBsum" id="3G5A"/>
    <dbReference type="PDBsum" id="3G6K"/>
    <dbReference type="PDBsum" id="4KKV"/>
    <dbReference type="AlphaFoldDB" id="Q6FNA9"/>
    <dbReference type="SMR" id="Q6FNA9"/>
    <dbReference type="FunCoup" id="Q6FNA9">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNA9"/>
    <dbReference type="EnsemblFungi" id="CAGL0K01397g-T">
        <property type="protein sequence ID" value="CAGL0K01397g-T-p1"/>
        <property type="gene ID" value="CAGL0K01397g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890055"/>
    <dbReference type="CGD" id="CAL0134421">
        <property type="gene designation" value="FMNAT"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01397g"/>
    <dbReference type="eggNOG" id="KOG2644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056971_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FNA9"/>
    <dbReference type="OMA" id="TVFIDQE"/>
    <dbReference type="BRENDA" id="2.7.1.26">
        <property type="organism ID" value="1113"/>
    </dbReference>
    <dbReference type="BRENDA" id="2.7.7.2">
        <property type="organism ID" value="1113"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q6FNA9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000245">
        <property type="entry name" value="FAD synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000462797" description="FAD synthase">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 12">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 14">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 12">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 12">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 13 14">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 14">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 12">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 14">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 12">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 13 14">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="mutagenesis site" description="Decreases enzyme activity." evidence="5">
        <original>N</original>
        <variation>A</variation>
        <variation>S</variation>
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Strongly decreases enzyme activity." evidence="5">
        <original>D</original>
        <variation>A</variation>
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Strongly decreases enzyme activity." evidence="5">
        <original>D</original>
        <variation>A</variation>
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Increases enzyme activity. Decreases inhibition of activity by FAD." evidence="5">
        <original>D</original>
        <variation>A</variation>
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Decreases enzyme activity." evidence="5">
        <original>W</original>
        <variation>A</variation>
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Increases enzyme activity." evidence="5">
        <original>R</original>
        <variation>A</variation>
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="mutagenesis site" description="Strongly decreases enzyme activity." evidence="5">
        <original>R</original>
        <variation>A</variation>
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O74841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P38913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q8NFF5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="19375431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="23663086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000312" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="11">
        <source>
            <dbReference type="PDB" id="3FWK"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="12">
        <source>
            <dbReference type="PDB" id="3G59"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="13">
        <source>
            <dbReference type="PDB" id="3G5A"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="14">
        <source>
            <dbReference type="PDB" id="3G6K"/>
        </source>
    </evidence>
    <evidence type="ECO:0007744" key="15">
        <source>
            <dbReference type="PDB" id="4KKV"/>
        </source>
    </evidence>
    <sequence length="304" mass="35586" checksum="096BA253A955E063" modified="2004-07-19" version="1">MRLGDAAELCYNLTSSYLQIAAESDSIIAQTQRAINTTKSILINETFPKWSPLNGEISFSYNGGKDCQVLLLLYLSCLWEYYIVKLSQSQFDGKFHRFPLTKLPTVFIDHDDTFKTLENFIEETSLRYSLSLYESDRDKCETMAEAFETFLQVFPETKAIVIGIRHTDPFGEHLKPIQKTDANWPDFYRLQPLLHWNLANIWSFLLYSNEPICELYRYGFTSLGNVEETLPNPHLRKDKNSTPLKLNFEWEIENRYKHNEVTKAEPIPIADEDLVKIENLHEDYYPGWYLVDDKLERAGRIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNB9</accession>
    <name>Q6FNB9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0K01177g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNB9"/>
    <dbReference type="FunCoup" id="Q6FNB9">
        <property type="interactions" value="1050"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNB9"/>
    <dbReference type="KEGG" id="cgr:2890160"/>
    <dbReference type="CGD" id="CAL0134561">
        <property type="gene designation" value="CAGL0K01177g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01177g"/>
    <dbReference type="eggNOG" id="KOG3313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083737_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNB9"/>
    <dbReference type="OMA" id="YNWDVAQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0134561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="190" mass="22016" checksum="F16E14846F825B84" modified="2004-07-19" version="1">MDTLFNSTEKNPRGIPSAPFLEDIGAFMAKEKEFELVFSKFQERLSKYKFMLESKQATVRQLHVRIPDIENTLQVCRQLKQSKEDGEESALKFNYKLNETLFTKAQVDLTKDLNVGLWLGADVMLEYPIDEAIALLEKKLEDSQDSLRIAKEDVEFLRENITTMEVNCARLYNWDVELRKATKATEKLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNP5</accession>
    <name>Q6FNP5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine-protein phosphatase-like protein OCA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0J10098g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNP5"/>
    <dbReference type="FunCoup" id="Q6FNP5">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNP5"/>
    <dbReference type="KEGG" id="cgr:2889409"/>
    <dbReference type="CGD" id="CAL0129927">
        <property type="gene designation" value="CAGL0J10098g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10098g"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047845_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FNP5"/>
    <dbReference type="OMA" id="MPLNYSF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF74">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE-LIKE PROTEIN OCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0129927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG61100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21415" checksum="3B8DC5A6CEC111B6" modified="2004-07-19" version="1">MSGGRAKYIPPLNFAPIVSTDVSLYRSGYPMPLNYSFIRGQLHLKTIIYVGDKSEPMPEYAEFLERERINYHHIHMDSCRDPDIDAQMDRVLQLVLRADNYPILIHSNKGKHRVGVVVGIIRKLLQGWSIAGIYQEYGLFSGGLKDEADLEYITMFETDILMDPRTVPRFALRRHHPTVIQQETTP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNP9</accession>
    <name>TRM6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
            <shortName>tRNA(m1A58)MTase subunit TRM6</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TRM6</name>
        <name type="ordered locus">CAGL0J10010g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNP9"/>
    <dbReference type="SMR" id="Q6FNP9"/>
    <dbReference type="FunCoup" id="Q6FNP9">
        <property type="interactions" value="1003"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNP9"/>
    <dbReference type="EnsemblFungi" id="CAGL0J10010g-T">
        <property type="protein sequence ID" value="CAGL0J10010g-T-p1"/>
        <property type="gene ID" value="CAGL0J10010g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889430"/>
    <dbReference type="CGD" id="CAL0133494">
        <property type="gene designation" value="CAGL0J10010g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10010g"/>
    <dbReference type="eggNOG" id="KOG1416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010916_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FNP9"/>
    <dbReference type="OMA" id="TRCRPYQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038170">
        <property type="entry name" value="tRNA_m1A_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000256161" description="tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6">
        <location>
            <begin position="1"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P41814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="473" mass="53962" checksum="1C5E62CC3C4DB958" modified="2004-07-19" version="1">MDPLKSIVQDQHVILTLPSGNSKIVELKPDSSVSLGKFGAFQVNDILGWPLGTTFEIYYDNVEEIVENKKKKPKSNELNKVPVGKVRLYKEVATDDKAEEEVEEMDSSAVIPVELQNVLSSATNQGLINIGNDVQKLTMHDVERFKQQSASANEIITKMIESHGSFHQKTIYSQEKYLKRKKQKFAKFFTVDYLSSSMLLKFLVEKGDIQRVLDLSEESLGMILNLTNIRSDGTYLCMDETGGLIVYTMLERMFGGKEDLDAPGKIVVINENEHPNLDLLKFSNYSEKFIEKHVVTLSILDYFRPPTMEEVEGRFTPLSKEEVNKLKSGKRSAYSRKLKWYYTQLRVIEMATKQQYDGLVVASTLHLPSLVPRLAERVHGARPIVCFSQFKETLLELAHTLYSDLRYLAPTILETRCRPYQTARGKLHPLMTMRGGGGYLLWCHRVIPAPEPEIEEPTDVNADEQEEKKQKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNZ2</accession>
    <name>Q6FNZ2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Folic acid synthesis protein fol1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0J07920g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes three sequential steps of tetrahydrofolate biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 16">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the N-terminal section; belongs to the DHNA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the central section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNZ2"/>
    <dbReference type="FunCoup" id="Q6FNZ2">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNZ2"/>
    <dbReference type="KEGG" id="cgr:2889859"/>
    <dbReference type="CGD" id="CAL0132972">
        <property type="gene designation" value="CAGL0J07920g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07920g"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FNZ2"/>
    <dbReference type="OMA" id="ESEPMYF"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005740">
        <property type="term" value="C:mitochondrial envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000014">
        <property type="entry name" value="Folic acid synthesis protein fol1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016261">
        <property type="entry name" value="Folic_acid_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00526">
        <property type="entry name" value="folB_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000741">
        <property type="entry name" value="Folic_acid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 16" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="17">
        <location>
            <begin position="499"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0132972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG61003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="807" mass="90692" checksum="B934EED4ED7D5FBD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP68</accession>
    <name>Q6FP68_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">oxaloacetate tautomerase</fullName>
            <ecNumber evidence="10">5.3.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAGL0J06204g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>oxaloacetate = enol-oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:16021"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17479"/>
            <dbReference type="EC" id="5.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:16023"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP68"/>
    <dbReference type="FunCoup" id="Q6FP68">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP68"/>
    <dbReference type="KEGG" id="cgr:2889580"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FP68"/>
    <dbReference type="OMA" id="WNIAETI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000014">
        <property type="entry name" value="Uncharacterized mitochondrial hydrolase FMP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="12">
        <location>
            <begin position="11"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="261" mass="29023" checksum="C44BEDBD4E11342D" modified="2004-07-19" version="1">MSYTYLKDAKKIICIGRNYAAHIKELNNATPKQPFFFLKPMSSVVTPVDEKHAIKELPKQASYHGLNDDGTNPGTIQIPKGTVVHHEIEVALVMDKYISNANESEFTAADVYDSIRGVALALDLTARNVQDEAKKKGLPWSIGKGFDTFLPMSHMIPKTKFEANKENLQEAFRVTCDVNGTRRQDGNTNLMLYPLHKIIQHISTMMTLEPGDIILTGTPAGVGPIAAGDNISGQLYYTDDLLIDFNFDCVVRPGPYEYKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPH4</accession>
    <name>Q6FPH4_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0J03806g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447870.1">
        <property type="nucleotide sequence ID" value="XM_447870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPH4"/>
    <dbReference type="FunCoup" id="Q6FPH4">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPH4"/>
    <dbReference type="KEGG" id="cgr:2889657"/>
    <dbReference type="CGD" id="CAL0133648">
        <property type="gene designation" value="CAGL0J03806g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03806g"/>
    <dbReference type="eggNOG" id="ENOG502QSEV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036523_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPH4"/>
    <dbReference type="OMA" id="ANFYHSG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051457">
        <property type="term" value="P:maintenance of protein location in nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061186">
        <property type="term" value="P:negative regulation of silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="420" mass="46683" checksum="21D0E25169AEF3E9" modified="2004-07-19" version="1">MTWNKTATYEHISSIKPRFISRAFAAENQLKSLAFSNELVPDTDAHELKTKLLYSQGSEIYELECAYPLITEDKEPVSDYGDAFKAMENVPLQPKWVYQGETVAKMEFLGEEEDTNVIAMSKNGSLAWFTEGVKVPVHIVQEMMGPSTKFSSIHSLTRPDNLAVADFSLSLDQETIVKSQSNGDEEDSILKLIDNAGKPSEVLRVIRVPGTTVTHSVRFLDNHVFASCSDDNVIRFWDTRTADKPLWSLSDPQNGSLTAFDVSQLSGNLFATGFSTGVVKLWDARAVEDATLDLSNRQNGEEPIQKEIANWYHRGGDSVVDLKFSSTSPTEFLTVGGSGNVYHWDADYALSNYDPENHAPQEASEQLQNESLTFLHTGGSRRSTTAYGLRNTVAWHPVIEGLVAHVDPDTLITTYLPYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPN8</accession>
    <name>Q6FPN8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar import and degradation protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0J02332g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPN8"/>
    <dbReference type="FunCoup" id="Q6FPN8">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPN8"/>
    <dbReference type="KEGG" id="cgr:2889759"/>
    <dbReference type="CGD" id="CAL0132764">
        <property type="gene designation" value="CAGL0J02332g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02332g"/>
    <dbReference type="eggNOG" id="KOG1293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_316687_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPN8"/>
    <dbReference type="OMA" id="LRHLMYN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038739">
        <property type="entry name" value="ARMC8/Vid28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15651:SF7">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="767"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0132764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="894" mass="102594" checksum="2D7D2C5ECB32929E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPQ5</accession>
    <name>Q6FPQ5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J01936g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPQ5"/>
    <dbReference type="FunCoup" id="Q6FPQ5">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPQ5"/>
    <dbReference type="KEGG" id="cgr:2889814"/>
    <dbReference type="CGD" id="CAL0132900">
        <property type="gene designation" value="CAGL0J01936g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01936g"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025145_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FPQ5"/>
    <dbReference type="OMA" id="RPALMDK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0132900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="425" mass="48084" checksum="77F8519677C9F31F" modified="2004-07-19" version="1">MVVDSTYYDLLGIGPTATAVEIKKAYRKKSIQEHPDKNPNDPTATERFQAISEAYQVLSSEELRAKYDKFGKQEAIPKGGFEDAAEQFSAIFGGEAFASYIGELTLLKNLQKTEELNAEDEAQKQKEAEEAQKRKEKEEEMKKNGHVQGSGQDITVHPDPEGTKPKDDAVNQKKKTKLEEFEEQQKIEREKRIEELSKTLIERLSILTESVYDDACKNSFQKKFEEEANMLKMESFGVDILHTIGDIYCEKAKIFLASQNLFGFGGIFHSVKAKGGVLMDTLRTVSAAIDAQNTMKELEKMKEASTEDTEENSKNQQKTETETTTAPKPKPTAEELAQQEQLLMGKVLSAAWHGTKFEMTSTLRSVCDKVLDDQKIDLNTRIKRAEALRLLGKVFQKTYRTKSEQEEAQIFEELVAEATKKHRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPR4</accession>
    <name>Q6FPR4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GLM6</name>
        <name evidence="13 14" type="ordered locus">CAGL0J01595g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447780.1">
        <property type="nucleotide sequence ID" value="XM_447780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPR4"/>
    <dbReference type="STRING" id="284593.Q6FPR4"/>
    <dbReference type="GeneID" id="2889822"/>
    <dbReference type="KEGG" id="cgr:2889822"/>
    <dbReference type="CGD" id="CAL0133158">
        <property type="gene designation" value="GLM6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01595g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_806531_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPR4"/>
    <dbReference type="OMA" id="GQKESTH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000594">
        <property type="entry name" value="Transcription factor HIVEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0133158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG60727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="344" mass="39313" checksum="7131180CB143E782" modified="2004-07-19" version="1">MLSICRIFCKLILTPCDFEVSIKPQKTLPIMIAMDDRYYNLENKFVPVGLPAVSPSAQYYPADASRPQSNVQSPVYYVPQNQINYIQRPSVSYVPTMEDQQYTYTTMAHPQQQMILPVRNASPIEVQQQQLQQQQLQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPLVKLPPISAIIPPGNSSPVNTTGQVQTSDQARNYNPGFRQDVQIALNPKSLSAPTSGRNSISINPLMYNPHQQQQLLALAGVSIPPTLMEHQLTDAMTKQEIKLTKRQLKKATTRLRKQCPVCGKICSRPSTLKTHILIHTGDTPFKCTWKDCRKAFNVKSNLLRHLKSHEKNSLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPR6</accession>
    <name>Q6FPR6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0J01529g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPR6"/>
    <dbReference type="FunCoup" id="Q6FPR6">
        <property type="interactions" value="274"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPR6"/>
    <dbReference type="KEGG" id="cgr:2889819"/>
    <dbReference type="CGD" id="CAL0133752">
        <property type="gene designation" value="CAGL0J01529g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01529g"/>
    <dbReference type="eggNOG" id="KOG4299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016350_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPR6"/>
    <dbReference type="OMA" id="CCDPPIE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060195">
        <property type="term" value="P:negative regulation of antisense RNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="273"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0133752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="671" mass="75938" checksum="911698D67B6F2CB0" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ60</accession>
    <name>Q6FQ60_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Checkpoint serine/threonine-protein kinase BUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0I08899g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ60"/>
    <dbReference type="KEGG" id="cgr:2889013"/>
    <dbReference type="CGD" id="CAL0132274">
        <property type="gene designation" value="CAGL0I08899g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08899g"/>
    <dbReference type="eggNOG" id="KOG1166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002115_1_0_1"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="10">
        <location>
            <begin position="28"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="620"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="266"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="526"/>
            <end position="546"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="261"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
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            <begin position="526"/>
            <end position="539"/>
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    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="648"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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            <dbReference type="ARBA" id="ARBA00022454"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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        <source>
            <dbReference type="PROSITE" id="PS51489"/>
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        <source>
            <dbReference type="CGD" id="CAL0132274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG60571.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="931" mass="106981" checksum="3C2D3FF6FFD92564" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ73</accession>
    <name>Q6FQ73_CANGA</name>
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        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0I08569g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG60558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08569g"/>
    <dbReference type="eggNOG" id="KOG2604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011639_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ73"/>
    <dbReference type="OMA" id="DEFELWG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140312">
        <property type="term" value="F:cargo adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000301">
        <property type="term" value="P:retrograde transport, vesicle recycling within Golgi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="85"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="253"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0132438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="777" mass="90575" checksum="C260FD3E00EDFB45" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ84</accession>
    <name>Q6FQ84_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0I08327g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ84"/>
    <dbReference type="FunCoup" id="Q6FQ84">
        <property type="interactions" value="1275"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ84"/>
    <dbReference type="KEGG" id="cgr:2889403"/>
    <dbReference type="CGD" id="CAL0130274">
        <property type="gene designation" value="CAGL0I08327g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08327g"/>
    <dbReference type="eggNOG" id="KOG0466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FQ84"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005525">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:methionyl-initiator methionine tRNA binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EFTu-like_2"/>
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    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0130274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60547.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQB0</accession>
    <name>Q6FQB0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I07711g</name>
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    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
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                <person name="Thierry A."/>
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                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="240"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="574" mass="66532" checksum="30A70129A9D41B77" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQM5</accession>
    <name>Q6FQM5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0I05038g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQM5"/>
    <dbReference type="FunCoup" id="Q6FQM5">
        <property type="interactions" value="1468"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQM5"/>
    <dbReference type="KEGG" id="cgr:2889087"/>
    <dbReference type="CGD" id="CAL0132724">
        <property type="gene designation" value="CAGL0I05038g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05038g"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013173_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FQM5"/>
    <dbReference type="OMA" id="CLLHDRP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903753">
        <property type="term" value="P:negative regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904289">
        <property type="term" value="P:regulation of mitotic DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0132724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG60406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="459" mass="50753" checksum="52A2989CE9740C6C" modified="2004-07-19" version="1">MGQILSNPVIDKEHHSGADLLTAFGLCAMQGWRMSMEDAHIVEPNVLPETDDEHIAFYSIFDGHGGSAVAQFCGSKMVSILTSQESFKEKKLKQALIDTYLKTDEELLKDPEMRNDHSGCTATSILVSKLQQTLVCGNSGDSRTVLSINGVAKALSFDHKPTLTSERSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNDKLGPHEQIVTCVPDIVEHRLNYDNDEFVILACDGIWDCLSSQECVDLVHHGIMKGDMSLNDISSRIIDVCCSPTTEGTGIGCDNVSIVVVALLKENETINAWFERMRNKGYKPPHSFEEQRRSIFSYYQFPEDDEKVFDVTTKKPQDRFNQDSEISTGDEDERNKMEIDEDDNDRSGAQKKTGASIPVDLLSLEALLNGAGNIQLNQGPDNVSYISGSSLTDMINSLSRAAAMANNTRDSDSEEEDTKIIEDVSDKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQU0</accession>
    <name>Q6FQU0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0I03586g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQU0"/>
    <dbReference type="FunCoup" id="Q6FQU0">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQU0"/>
    <dbReference type="KEGG" id="cgr:2889183"/>
    <dbReference type="CGD" id="CAL0132294">
        <property type="gene designation" value="CAGL0I03586g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03586g"/>
    <dbReference type="eggNOG" id="KOG0221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_8_0_1"/>
    <dbReference type="InParanoid" id="Q6FQU0"/>
    <dbReference type="OMA" id="CSVYFMP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
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        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
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        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
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        <property type="entry name" value="MutS"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
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        <property type="entry name" value="MUTSac"/>
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        <property type="entry name" value="DNA repair protein MutS, domain III"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="238"/>
            <end position="570"/>
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        <location>
            <begin position="597"/>
            <end position="798"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0132294"/>
        </source>
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    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60341.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
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    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="99495" checksum="3D130C3B4ADF0DBC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRD5</accession>
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        <recommendedName>
            <fullName evidence="17">Protein BIM1</fullName>
        </recommendedName>
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        <name evidence="14 15" type="ordered locus">CAGL0H09438g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
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        <property type="protein sequence ID" value="CAG60142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG3000">
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        <property type="component" value="Chromosome H"/>
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        <property type="term" value="C:cytoplasmic microtubule"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:microtubule plus-end"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
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        <property type="term" value="C:spindle pole"/>
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        <property type="term" value="F:microtubule plus-end binding"/>
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        <property type="term" value="P:2-micrometer plasmid partitioning"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:microtubule depolymerization"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mitotic sister chromatid cohesion"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904825">
        <property type="term" value="P:protein localization to microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
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        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="13">
        <location>
            <begin position="197"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="113"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0130277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36808" checksum="4050EB9BF2C9D42A" modified="2004-07-19" version="1">MSGIGESRTELLNWLNDLLKLNYKKIEECGTGAAYCQIMDSIYGDVPMHRVRFNSTADYENQINYKVLQSNFTKHNIEKTVYVDKLIRCRFQDNLEFLQWLKKYWVNNKDGTPYDAEARRNYRPISSTNSGTPGTPSGLSSASNSSSTLNISKRRNMSDSTSLSRTQSLSTRYASGTSGNNINRRVTSEQIIALQTELSQSHNKIQEMEQEMGTFKEALTAMEAENNFYFSKLRDIEILVQTTQDFIKEGLYKGDVEELDKFTNKVQHILYATIESASNEETKDTNESNRITTNNTSSGNIASQTLEGESLRSSNNLIIDEETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRD9</accession>
    <name>Q6FRD9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0H09350g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FRD9">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRD9"/>
    <dbReference type="KEGG" id="cgr:2888633"/>
    <dbReference type="CGD" id="CAL0131526">
        <property type="gene designation" value="CAGL0H09350g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09350g"/>
    <dbReference type="eggNOG" id="KOG1140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238060_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRD9"/>
    <dbReference type="OMA" id="WANTISM"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990303">
        <property type="term" value="C:UBR1-RAD6 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904855">
        <property type="term" value="F:proteasome regulatory particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034620">
        <property type="term" value="P:cellular response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072671">
        <property type="term" value="P:mitochondria-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090089">
        <property type="term" value="P:regulation of dipeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120174">
        <property type="term" value="P:stress-induced homeostatically regulated protein degradation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19672">
        <property type="entry name" value="UBR-box_UBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF26">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="12">
        <location>
            <begin position="108"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="108"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="272"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1929"/>
            <end position="1965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1955"/>
            <end position="1965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0131526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG60138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1965" mass="226481" checksum="513D52120E150C8A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRK9</accession>
    <name>Q6FRK9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0H07755g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRK9"/>
    <dbReference type="FunCoup" id="Q6FRK9">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRK9"/>
    <dbReference type="KEGG" id="cgr:2888559"/>
    <dbReference type="CGD" id="CAL0131588">
        <property type="gene designation" value="CAGL0H07755g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07755g"/>
    <dbReference type="eggNOG" id="ENOG502S4CU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097653_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRK9"/>
    <dbReference type="OMA" id="HICAMYG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF14">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_25, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="172" mass="18726" checksum="7580B59C5DA915ED" modified="2004-07-19" version="1">MSSEGASAGEQLLDASRRNNSDLLSSIFETLGHDAEKIAELINTSKDPLGNTALHLCCKYGSWEVLDTILDQEGGIDIDPQNVDGDTPLHVTVRYCDEEPEHGLFIARNLIEVGADPRIKNINNQLPLDLVHGDDKDELIDLLQGAALAADNYDGDEGDEPELIDDDDGEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRR1</accession>
    <name>Q6FRR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0H06611g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447083.1">
        <property type="nucleotide sequence ID" value="XM_447083.1"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRR1"/>
    <dbReference type="KEGG" id="cgr:2888660"/>
    <dbReference type="CGD" id="CAL0131924">
        <property type="gene designation" value="CAGL0H06611g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06611g"/>
    <dbReference type="eggNOG" id="ENOG502QQKF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006407_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRR1"/>
    <dbReference type="OMA" id="PEVWKCW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="732"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="PIN" evidence="3">
        <location>
            <begin position="1085"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1213"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0131924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1282" mass="147222" checksum="DD60216A72D5BEA2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRR7</accession>
    <name>Q6FRR7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">REH1</name>
        <name evidence="11 12" type="ordered locus">CAGL0H06479g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447077.1">
        <property type="nucleotide sequence ID" value="XM_447077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRR7"/>
    <dbReference type="FunCoup" id="Q6FRR7">
        <property type="interactions" value="632"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRR7"/>
    <dbReference type="GeneID" id="2888835"/>
    <dbReference type="KEGG" id="cgr:2888835"/>
    <dbReference type="CGD" id="CAL0131784">
        <property type="gene designation" value="REH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06479g"/>
    <dbReference type="eggNOG" id="KOG2785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018787_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FRR7"/>
    <dbReference type="OMA" id="QRYHMKT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="74"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="99"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0131784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="411" mass="47023" checksum="000C0A53874D9D19" modified="2004-07-19" version="1">MSSTFTCNSCDIQFQTSDSQRYHMKTEWHRYNLKRRVANLPHISASMFAEKVQMSEREKREHMVDEFGFEILKAPDHGRKHKKRGSAAKPTSKEDKSEVPSNNIKSSANALHRTISPTESVASEMSALTTGSEYNTTDFGEDTASEYGFTSDSNYDYGSTTDESSDEEDHKLSVKHNHDDFKTTTCIYCGVENKEVERNIRHMFKSHGLYIPERSYLIDLDGLLKFLINHILVENKCMCCNYQGSSVESIRAHMDSKRHCKLPYETREERAVVGEFYDFSSLYSDEENEESENADDVEEAAGDSNGINSNYTVATIDDSGAELTLPTGVRLGHREGQRYYRQNLPLPPNHGESRRTVTAADRRMISGVTEKQYKKGMKKMQLLEQKAASEQIRKEVKRVNFQPHFRDPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRW7</accession>
    <name>Q6FRW7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H05313g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447027.1">
        <property type="nucleotide sequence ID" value="XM_447027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRW7"/>
    <dbReference type="FunCoup" id="Q6FRW7">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888861"/>
    <dbReference type="CGD" id="CAL0129799">
        <property type="gene designation" value="CAGL0H05313g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05313g"/>
    <dbReference type="HOGENOM" id="CLU_138673_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRW7"/>
    <dbReference type="OMA" id="IRTRWIV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0129799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="159" mass="18868" checksum="AE801E3974D7BDDA" modified="2004-07-19" version="1">MGFSRNFKGDSRKRPHSPDLYAIGEFKKSKLIEDLERLSLNDDVVSENNGLQIVDHNKFRRPHKDDTSHPGDRKWVITQIVDLMRAESLQVIPWIDYKQFAYNEWLKWYKIKLLSDDTLMIDIDNLLENDFYMRVEPTSNYRGQIEGNNETEDMDIDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRX5</accession>
    <name>Q6FRX5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0H05137g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRX5"/>
    <dbReference type="FunCoup" id="Q6FRX5">
        <property type="interactions" value="1040"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRX5"/>
    <dbReference type="KEGG" id="cgr:2888474"/>
    <dbReference type="CGD" id="CAL0130512">
        <property type="gene designation" value="CAGL0H05137g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05137g"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FRX5"/>
    <dbReference type="OMA" id="KTYMGPL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="31"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0130512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="497" mass="54239" checksum="9D5062B398F856FB" modified="2004-07-19" version="1">MAYKTAATKTIKLPNGLTYEQPTGLFINNEFVESSDGKTMTIENPSTQEPIVDVFSATKEDVDYAVDCAERAFEKSDWATQDPKVRARYLSKLADLMEEQLELIASIETLDNGKTIALSRGDVQLSINCIRDAASYADKVDGRSIDTGDGYMNYTIREPIGVCAQIIPWNFPLMMLSWKVGPALAMGNCIVLKPASATPLNALYFSSLCKQVGIPAGVVNIIPGPGGMVGTALTTHPKVRKVAFTGSTDIGKDIAVKASASNLKKITLELGGKSAHLVFNDANLEKTLPNLVNGIFKNAGQICSSGSRIYAQAGIYDRLLKEFKAYIEKNIKVGNPFDESNFQGAITNKEQYNTILKYINIGKEEGAKVLTGGETAAEKGYFIKPTVFYDVKEDMRVVKEEIFGPCVTISKFEEIEDGVAMANDSEFGLGAGIETENLSTALKVAKMLHSGTVWINTYNDFDSRVPFGGYKQSGYGREMGSEVYECYTQTKAVRIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS00</accession>
    <name>Q6FS00_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0H04587g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS00"/>
    <dbReference type="STRING" id="284593.Q6FS00"/>
    <dbReference type="KEGG" id="cgr:2888829"/>
    <dbReference type="CGD" id="CAL0131696">
        <property type="gene designation" value="CAGL0H04587g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04587g"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009020_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FS00"/>
    <dbReference type="OMA" id="DSIHHQR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="414"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="2"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0131696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="445" mass="48663" checksum="8D9512229B210374" modified="2004-07-19" version="1">MSTARSGVVTLLHTACGAGILAIPYAFRPFGLVPAIFMLLFCGLCSMMGLLLQSRIAKYGPLKNVSFFSLAQVVNPASSILFDAAIAIKCFGVGVSYMIVVGDLMPKIWSRVSSSGLLLSRNVNITLVMLFIVGPLCFMRRLNSLRYASMIAIGSVAYLCILVIVHFAHQTTELRELKGEVSVGLPHGEPTPLTTLPIFVFAYTCHHNMFSVINEQKNTGFTYVRYIAIVSILVAFVLYVVIGSTGYLTFGDNITGNIIALYPDTLSTTIGRIAIVLLVMLAFPLQCHPARESINNMIKYVQDRYSPQTSYELTAVDADNLEINNDVTSINSRANDKEEECMDTKRFMIITACILFCSYLLAISVTSLARVLAIVGATGSTTISFILPGYFGWSLIGTEYTSNGNQLPLRKSTVIFKYIGLVMTIWGIIIMITSLIASLFFGASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS26</accession>
    <name>Q6FS26_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CIT1</name>
        <name evidence="5 6" type="ordered locus">CAGL0H03993g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446968.1">
        <property type="nucleotide sequence ID" value="XM_446968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS26"/>
    <dbReference type="FunCoup" id="Q6FS26">
        <property type="interactions" value="1020"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS26"/>
    <dbReference type="GeneID" id="2888584"/>
    <dbReference type="KEGG" id="cgr:2888584"/>
    <dbReference type="CGD" id="CAL0131702">
        <property type="gene designation" value="CIT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03993g"/>
    <dbReference type="eggNOG" id="KOG2617">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FS26"/>
    <dbReference type="OMA" id="VLEWLFK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF8">
        <property type="entry name" value="CITRATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="472" mass="52538" checksum="6BF8EBE74444FD74" modified="2004-07-19" version="1">MSLSSAARATPALRAQAYKALTSTRAFSATSISSEKTLKDTFADIFPKQAEEIKQFKKEHGKTVIDQLLLEQAYGGMRGIKGIVWEGSVLDPEEGIRFRGRTIPEIKKELPTIGGSSEPVPEALFWLLLTGEVPTESQVKAFSADLASRSEVPEHVLKLLDSLPKDLHPMAQLSIAVNALETESKFAKAYARGVNKKEYWSYTFEDSLDLLGKLPVIASKIYRNIFKDGKICQVDPNADYGKNLAHLLGYTNKDFVDLMRLYLTIHSDHEGGNVSAHTTHLVGSALSSPYLSFAAGMNGLAGPLHGRANQEVLEWLFTFREEVKGDYSKETVEKYLWDTLNGGRVIPGYGHAVLRKTDPRYTAQREFALKHFPDYELFKLVSTIYDVAPKVLTKHGKTKNPWPNVDSHSGVLLQYYGLTEASFYTVLFGVSRAFGVLPQLIIDRAVGAPIERPKSFSTEKFKELVKSIESKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS56</accession>
    <name>Q6FS56_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAGL0H03333g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS56"/>
    <dbReference type="FunCoup" id="Q6FS56">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS56"/>
    <dbReference type="KEGG" id="cgr:2888843"/>
    <dbReference type="eggNOG" id="KOG1590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099502_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FS56"/>
    <dbReference type="OMA" id="CTTHFWG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="132" mass="15145" checksum="1E9494ABB3F2E0F6" modified="2004-07-19" version="1">MSQPVQRAATRSIIQKYINKETLKYVFTTHFWGPVSNFGIPIAALYDLKKDPTLISGPMTLALVAYSGVFMKYALAVTPKNYLLFACHFINESAQLGQGYRFIDFNYFKSDEEKNKIIEEYKVKAEQANEKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS70</accession>
    <name>PAN2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="1">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="1">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PAN2</name>
        <name type="ordered locus">CAGL0H03025g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="1"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446924.1">
        <property type="nucleotide sequence ID" value="XM_446924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS70"/>
    <dbReference type="SMR" id="Q6FS70"/>
    <dbReference type="FunCoup" id="Q6FS70">
        <property type="interactions" value="747"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS70"/>
    <dbReference type="EnsemblFungi" id="CAGL0H03025g-T">
        <property type="protein sequence ID" value="CAGL0H03025g-T-p1"/>
        <property type="gene ID" value="CAGL0H03025g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888907"/>
    <dbReference type="KEGG" id="cgr:2888907"/>
    <dbReference type="CGD" id="CAL0132004">
        <property type="gene designation" value="CAGL0H03025g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H03025g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03025g"/>
    <dbReference type="eggNOG" id="KOG1275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002369_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FS70"/>
    <dbReference type="OMA" id="TQELLWT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000295341" description="PAN2-PAN3 deadenylation complex catalytic subunit PAN2">
        <location>
            <begin position="1"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2" evidence="1">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3" evidence="1">
        <location>
            <begin position="197"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4" evidence="1">
        <location>
            <begin position="295"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="462"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease" evidence="1">
        <location>
            <begin position="888"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="1">
        <location>
            <begin position="336"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="891"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="893"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1000"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="1051"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <sequence length="1093" mass="123992" checksum="A7F5CE68F766C6C9" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSA6</accession>
    <name>Q6FSA6_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">STE12B</name>
        <name evidence="7 8" type="ordered locus">CAGL0H02145g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSA6"/>
    <dbReference type="STRING" id="284593.Q6FSA6"/>
    <dbReference type="KEGG" id="cgr:2888874"/>
    <dbReference type="CGD" id="CAL0131488">
        <property type="gene designation" value="STE12B"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02145g"/>
    <dbReference type="eggNOG" id="ENOG502QTVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435447_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSA6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000220">
        <property type="term" value="P:regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="580"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0131488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="628" mass="70640" checksum="93B2811CE0201D65" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSN0</accession>
    <name>Q6FSN0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MINDY deubiquitinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G09251g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSN0"/>
    <dbReference type="FunCoup" id="Q6FSN0">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSN0"/>
    <dbReference type="KEGG" id="cgr:2888049"/>
    <dbReference type="CGD" id="CAL0129783">
        <property type="gene designation" value="CAGL0G09251g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09251g"/>
    <dbReference type="eggNOG" id="KOG2427">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022566_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FSN0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016807">
        <property type="term" value="F:cysteine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007518">
        <property type="entry name" value="MINDY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033979">
        <property type="entry name" value="MINDY_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063">
        <property type="entry name" value="NF-E2 INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18063:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04424">
        <property type="entry name" value="MINDY_DUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MINDY deubiquitinase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="363" mass="40936" checksum="DA7889C23655BCD9" modified="2004-07-19" version="1">MNFATKRIRVDGNDRSILMQNENGPCALVALTNVLLLSSHHEHSELLELVQPKKVDLDQLLTVLADIAIATNPKDEELSVLLSLLPQLHTGLNINPRFDGTFEDTKELSVFKLFDIDIIHGWISSDDKVQKYTYEESQQLLTQAVDIRDRETPGSGNPQDDNILAEANLIEQFLNDSSTQLTPNGLNNINTTMKEGNYAVLFRNDHFATITKHNGNTYALVTDLGFRSCNNIVWEYMGSIDGSNDIFFDGIFEETELNDTAYTTMEATERKERVEQVDKDAQLAQQLQLEENEAIQEADKKQLPKKSTIPKTKTDKRGTNHHQTPSNATYKHTHSHHSRKNNKKHNSMNANASNKKSSDCVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSQ1</accession>
    <name>Q6FSQ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Nuclear protein STH1/NPS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">STH1</name>
        <name evidence="18 19" type="ordered locus">CAGL0G08756g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446743.1">
        <property type="nucleotide sequence ID" value="XM_446743.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FSQ1">
        <property type="interactions" value="1197"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSQ1"/>
    <dbReference type="GeneID" id="2888093"/>
    <dbReference type="KEGG" id="cgr:2888093"/>
    <dbReference type="CGD" id="CAL0129255">
        <property type="gene designation" value="STH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08756g"/>
    <dbReference type="eggNOG" id="KOG0386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_15_3_1"/>
    <dbReference type="InParanoid" id="Q6FSQ1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140054">
        <property type="term" value="F:histone H2A reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:histone H3K14ac reader activity"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0140008">
        <property type="term" value="F:histone H4 reader activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:chromosome segregation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromatin structure-remodeling complex subunit rsc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000843">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
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        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
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        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SNF2-rel_dom"/>
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        <property type="entry name" value="BROMODOMAIN"/>
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        <property type="entry name" value="BROMO"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="BROMODOMAIN_1"/>
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        <property type="entry name" value="BROMODOMAIN_2"/>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="17">
        <location>
            <begin position="290"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="465"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="778"/>
            <end position="939"/>
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    </feature>
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        <location>
            <begin position="1267"/>
            <end position="1337"/>
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            <end position="1180"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1205"/>
            <end position="1233"/>
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    </feature>
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        <location>
            <begin position="1070"/>
            <end position="1080"/>
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    </feature>
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        <location>
            <begin position="1118"/>
            <end position="1127"/>
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            <begin position="1165"/>
            <end position="1174"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50014"/>
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    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0129255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG59670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1354" mass="156904" checksum="8DEFC885F3EF2B1D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSS1</accession>
    <name>Q6FSS1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0G08272g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSS1"/>
    <dbReference type="FunCoup" id="Q6FSS1">
        <property type="interactions" value="1187"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSS1"/>
    <dbReference type="KEGG" id="cgr:2888202"/>
    <dbReference type="CGD" id="CAL0137733">
        <property type="gene designation" value="CAGL0G08272g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08272g"/>
    <dbReference type="eggNOG" id="KOG0359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FSS1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0137733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="549" mass="60171" checksum="222D923CFC9A84B6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSV0</accession>
    <name>Q6FSV0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0G07645g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446694.1">
        <property type="nucleotide sequence ID" value="XM_446694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSV0"/>
    <dbReference type="KEGG" id="cgr:2888342"/>
    <dbReference type="CGD" id="CAL0130831">
        <property type="gene designation" value="CAGL0G07645g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07645g"/>
    <dbReference type="HOGENOM" id="CLU_2399445_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSV0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0130831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="93" mass="10157" checksum="8C57259B438E0D57" modified="2004-07-19" version="1">MFQIFSRFDILFIPATTRFPPLVCLNGMHIPKLGQSALSQGMTTVNHNLNYRHGNNELGSQIQAIGTLKDIHDLVAITGQHAPAPPQPLLASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT56</accession>
    <name>Q6FT56_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0G05247g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT56"/>
    <dbReference type="FunCoup" id="Q6FT56">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT56"/>
    <dbReference type="MEROPS" id="C19.005"/>
    <dbReference type="KEGG" id="cgr:2888255"/>
    <dbReference type="CGD" id="CAL0137673">
        <property type="gene designation" value="CAGL0G05247g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05247g"/>
    <dbReference type="eggNOG" id="KOG1868">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005922_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FT56"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000115">
        <property type="entry name" value="DOA4p Ubiquitin hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF95">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Rhodanese" evidence="9">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="583"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0137673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="947" mass="107424" checksum="84ABDE555E36E4B6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTB3</accession>
    <name>Q6FTB3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0G03883g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTB3"/>
    <dbReference type="FunCoup" id="Q6FTB3">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTB3"/>
    <dbReference type="KEGG" id="cgr:2888376"/>
    <dbReference type="CGD" id="CAL0130564">
        <property type="gene designation" value="CAGL0G03883g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03883g"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FTB3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035617">
        <property type="term" value="P:stress granule disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005991">
        <property type="term" value="P:trehalose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1780.10:FF:000003">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="14">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="414"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="892"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0130564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG59458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="908" mass="101926" checksum="173AA6B60A64CCAB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTE6</accession>
    <name>Q6FTE6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Exosome complex component RRP46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0G03113g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTE6"/>
    <dbReference type="FunCoup" id="Q6FTE6">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTE6"/>
    <dbReference type="KEGG" id="cgr:2888364"/>
    <dbReference type="CGD" id="CAL0137613">
        <property type="gene designation" value="CAGL0G03113g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03113g"/>
    <dbReference type="eggNOG" id="KOG1069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FTE6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071042">
        <property type="term" value="P:nuclear polyadenylation-dependent mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="131"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25547" checksum="CC7226187AB9A9F1" modified="2004-07-19" version="1">MSQDIVVELGLLSEVDGSAKLLMNSTNVLCAVTGPVEPKARQELPTEMALEVIVRPAKGVPTPREKYLEDKIRAIFTPLITRHKYPRQLCQITCQIMEAGENEQLHNQKELSACVNSALLALVNAGVALNDLAAAVTIAVIDDQSQENKAQYIIGPSDEELEKSSSVHTIAMEVGDNGKKVKRVLLIESNGIFNDKVIFDILELSESACLNLCSNWRGVLTKHIQKELDLQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTH8</accession>
    <name>Q6FTH8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0G02387g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59393.1"/>
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        <property type="gene designation" value="CAGL0G02387g"/>
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        <property type="term" value="F:Rho GDP-dissociation inhibitor activity"/>
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        <property type="entry name" value="LIM_Homeobox_TF"/>
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        <property type="entry name" value="Znf_LIM"/>
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        <property type="entry name" value="LIM HOMEOBOX TRANSCRIPTION FACTOR 1 ALPHA, ISOFORM B"/>
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        <property type="entry name" value="LIM/HOMEOBOX PROTEIN LHX"/>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
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    </dbReference>
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        <property type="entry name" value="LIM_DOMAIN_1"/>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="554"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="24"/>
            <end position="144"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="253"/>
            <end position="292"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="506"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="85"/>
            <end position="103"/>
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            <begin position="118"/>
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            <begin position="180"/>
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            <begin position="229"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50023"/>
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    <sequence length="709" mass="80289" checksum="D0150FE98E1530CC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTL3</accession>
    <name>Q6FTL3_CANGA</name>
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        <recommendedName>
            <fullName evidence="6">Alanyl-transfer RNA synthetases family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0G01606g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_446431.1"/>
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        <property type="gene designation" value="CAGL0G01606g"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01606g"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_7_1_1"/>
    <dbReference type="InParanoid" id="Q6FTL3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043905">
        <property type="term" value="F:L-seryl-tRNA(Thr) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002196">
        <property type="term" value="F:Ser-tRNA(Ala) deacylase activity"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
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        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
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    <dbReference type="InterPro" id="IPR051335">
        <property type="entry name" value="Alanyl-tRNA_Editing_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43462:SF1">
        <property type="entry name" value="ALANYL-TRNA EDITING PROTEIN AARSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0137553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG59358.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="456" mass="51074" checksum="9D75F3F6DBF1D001" modified="2004-07-19" version="1">MTVATPAVVGALKCQREPFLLEDFETNVISCVKVDSKTAKKFLIGKEATHVLELEDTILFPEGGGQPSDTGYVTLRDDETKRINVVKVVREGLHAKHYVDQAIEPGSKISLHVDKEKRLDYMQQHTGQHLLSAILDNYYDNADTLSWSMGGIPSTKKPILEPSDYLNYLELPRKLSKDEISEITDKFNEIVSTNVMPITVKETIAVEKSESIEDVSTKKIPDDYDYTLGVLRTINIGELDKNPCCGTHLTATSQVQSILILDNQSTVRGTNSRLYFMCGKRVSLYAKMLTDYISSAKVELSCSESQISSKVVALKENLQKAKKKEQYFISQIAKFEGERLYQSLEEGKQLYVLKDEFGSLDLLLAIQKEFQELCDKNSKNCELLILCGRERASLMGSVVIISPDGEKIQKTVSELQSALKNLKGGGGKNGGKWQGKIMNFTDQEYDVLEHYLEQIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUA0</accession>
    <name>Q6FUA0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0F05115g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUA0"/>
    <dbReference type="FunCoup" id="Q6FUA0">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887641"/>
    <dbReference type="CGD" id="CAL0131126">
        <property type="gene designation" value="CAGL0F05115g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05115g"/>
    <dbReference type="eggNOG" id="ENOG502QVQ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402815_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUA0"/>
    <dbReference type="OMA" id="DFKPYMD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="75176" checksum="266CFDAF3F9C9367" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUV7</accession>
    <name>Q6FUV7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycosyltransferase HOC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0F00297g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUV7"/>
    <dbReference type="FunCoup" id="Q6FUV7">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUV7"/>
    <dbReference type="CAZy" id="GT32">
        <property type="family name" value="Glycosyltransferase Family 32"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887672"/>
    <dbReference type="CGD" id="CAL0131252">
        <property type="gene designation" value="CAGL0F00297g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00297g"/>
    <dbReference type="eggNOG" id="ENOG502QW2I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022381_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FUV7"/>
    <dbReference type="OMA" id="WIPENVS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF11">
        <property type="entry name" value="GLYCOSYLTRANSFERASE HOC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0131252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="45243" checksum="85980855E15DB6DA" modified="2004-07-19" version="1">MTMARKRSNFKILRIFFFLIAGLAGIALLLKLSSNARASDIQKILQNLPKEITQSINVANSNQKADADVMAKFAKLAEDIKLKQEEQSKQFERQRKVLERKLRNMKQISTDATLREKLAYNFEYDGKSRFPAFLWQTWSGSQTPEEVLHVKATWQEKNPGFVHEILTPEMMNALVHHYYSIVPEVVEAYKLLPDNILRIDFFKYLVLLARGGTYADIDTSPLQPIPNWIPETVEPSDIGLTVGIEHDAQAVDWRSHYVRRLQFGTWVIQAKPGHPVLREVVAQIVEHVLNNKDDLSTVNVRNDLSVMKFTGSALFTDAIMTYLNDFIKSGLDRKVTWRDFTKITSPKLVSDILVFPEFSFNVPENFDKEDPLRAQFFISHKGEKFWKAAPKVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUW7</accession>
    <name>Q6FUW7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hyphally-regulated cell wall protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0E06600g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445977.1">
        <property type="nucleotide sequence ID" value="XM_445977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUW7"/>
    <dbReference type="STRING" id="284593.Q6FUW7"/>
    <dbReference type="KEGG" id="cgr:2887333"/>
    <dbReference type="CGD" id="CAL0128728">
        <property type="gene designation" value="CAGL0E06600g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06600g"/>
    <dbReference type="eggNOG" id="ENOG502QPQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306733_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUW7"/>
    <dbReference type="OMA" id="CEECTEY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000128">
        <property type="term" value="P:flocculation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001389">
        <property type="entry name" value="Flocculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021031">
        <property type="entry name" value="Hyphal-reg_cell_wall_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00624">
        <property type="entry name" value="Flocculin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11765">
        <property type="entry name" value="Hyphal_reg_CWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274211" description="Hyphally-regulated cell wall protein N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Hyphally-regulated cell wall protein N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="634"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="848"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="851"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="865"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="884"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0128728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="965" mass="104284" checksum="AD18B89FB19DAF71" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV89</accession>
    <name>Q6FV89_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0E03872g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV89"/>
    <dbReference type="FunCoup" id="Q6FV89">
        <property type="interactions" value="922"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV89"/>
    <dbReference type="KEGG" id="cgr:2887271"/>
    <dbReference type="CGD" id="CAL0128766">
        <property type="gene designation" value="CAGL0E03872g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E03872g"/>
    <dbReference type="eggNOG" id="KOG3208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078034_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FV89"/>
    <dbReference type="OMA" id="QAYAVND"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0128766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="224" mass="25632" checksum="948A538EFEE2BE4D" modified="2004-07-19" version="1">MSKGPSFVTVRSEAISRESKTESLLGKYSTYAQAASSDATSQEKHLDEQIEKLLGERQDIIDNLTKIAEDTPNISASKQSQLQRHREILQEHWKNFRGIRSSIQQERNRLNLLFSVKNDIAQQQQATDNELFNDEEAYNQNESRRIDQSHNILDRLIVQAWETRENFNAQSSTLNSAGNKALQTLQRIPGVNLLIGKIGTRRRKNAIILASVTTICILFLFFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVA0</accession>
    <name>Q6FVA0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAGL0E03630g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="584"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        </location>
    </feature>
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            <end position="746"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG58763.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVL0</accession>
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        <recommendedName>
            <fullName evidence="8">Assembly chaperone of RPL4</fullName>
        </recommendedName>
    </protein>
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        <name evidence="5 6" type="ordered locus">CAGL0E01067g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tom70 family.</text>
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        <property type="protein sequence ID" value="CAG58653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="cgr:2887306"/>
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    </dbReference>
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        <property type="component" value="Chromosome E"/>
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        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
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        <property type="entry name" value="ASSEMBLY CHAPERONE OF RPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2025-06-18" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVM9</accession>
    <name>SRB8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SRB8</name>
        <name type="synonym">MED12</name>
        <name type="ordered locus">CAGL0E00627g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445715.1">
        <property type="nucleotide sequence ID" value="XM_445715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVM9"/>
    <dbReference type="SMR" id="Q6FVM9"/>
    <dbReference type="FunCoup" id="Q6FVM9">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVM9"/>
    <dbReference type="EnsemblFungi" id="CAGL0E00627g-T">
        <property type="protein sequence ID" value="CAGL0E00627g-T-p1"/>
        <property type="gene ID" value="CAGL0E00627g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887477"/>
    <dbReference type="KEGG" id="cgr:2887477"/>
    <dbReference type="CGD" id="CAL0129076">
        <property type="gene designation" value="SRB8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00627g"/>
    <dbReference type="eggNOG" id="KOG4522">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_256280_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVM9"/>
    <dbReference type="OMA" id="EFIVYHQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990508">
        <property type="term" value="C:CKM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000411">
        <property type="term" value="P:positive regulation of transcription by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000312969" description="Mediator of RNA polymerase II transcription subunit 12">
        <location>
            <begin position="1"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1358" mass="158953" checksum="134E226348B2BCA4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVR3</accession>
    <name>Q6FVR3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA wybutosine-synthesizing protein 3</fullName>
            <ecNumber evidence="3">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0D06336g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TYW3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="3"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVR3"/>
    <dbReference type="FunCoup" id="Q6FVR3">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVR3"/>
    <dbReference type="KEGG" id="cgr:2887001"/>
    <dbReference type="CGD" id="CAL0128177">
        <property type="gene designation" value="CAGL0D06336g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D06336g"/>
    <dbReference type="eggNOG" id="KOG1228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047426_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVR3"/>
    <dbReference type="OMA" id="TWLYVSH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1960.10:FF:000003">
        <property type="entry name" value="tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="13">
        <location>
            <begin position="9"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0128177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="269" mass="30308" checksum="E2CBD62DDCCDD4A3" modified="2004-07-19" version="1">MSKQNAFDQKKLAILQEINSDQLDLSPKGTIDVLCLPIIDLINSSPDMVTTSSCSGRISVFIEGQKAINGDVKVGGKGDGGVWLFVSHEFKDIDNWFDRTTASKNLNWVIDASNTKDINDDGSSSMILYKYEPFILHVKCRDFESASKLYNTAMACGFRESGIGSNFIVAIRINIKLDVPIGYVKENGHLALIVDPSYITVLDRITKAKFIENEKKMTVLFAKIKSEIVESPKDVNTQVKEETKEERRERKRREGLEKQRLLQQKQIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVR4</accession>
    <name>Q6FVR4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAGL0D06314g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVR4"/>
    <dbReference type="FunCoup" id="Q6FVR4">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVR4"/>
    <dbReference type="KEGG" id="cgr:2887000"/>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006715_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FVR4"/>
    <dbReference type="OMA" id="QFYSVIT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.970.30">
        <property type="entry name" value="eIF4G, eIF4E-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022745">
        <property type="entry name" value="eIF4G1_eIF4E-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036211">
        <property type="entry name" value="eIF4G_eIF4E-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12152">
        <property type="entry name" value="eIF_4G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101489">
        <property type="entry name" value="Eukaryotic initiation factor 4f subunit eIF4g, eIF4e-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="MIF4G" evidence="9">
        <location>
            <begin position="642"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="524"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="906"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="914"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="944"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="990" mass="112635" checksum="A92B495202BAB0ED" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="148" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVR5</accession>
    <name>Q6FVR5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0D06292g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVR5"/>
    <dbReference type="FunCoup" id="Q6FVR5">
        <property type="interactions" value="1185"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVR5"/>
    <dbReference type="KEGG" id="cgr:2886965"/>
    <dbReference type="CGD" id="CAL0128079">
        <property type="gene designation" value="CAGL0D06292g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D06292g"/>
    <dbReference type="eggNOG" id="KOG0728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FVR5"/>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="174"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0128079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="400" mass="44708" checksum="10875B2F9F5ED999" modified="2004-07-19" version="1">MISKGMVHESGIKPYFEHKIQETELKIRGKTENLRRLEAQRNALNDEVRFIKDELRLLQEPGSYVGEVIKVVSDKKVLVKVQPEGKYIVDVAKDINVKDLKASQRVCLRSDSYMLHKVLVNKADPLVSLMMVEKVPDSTYDMVGGLTKQIKEIKEVIELPVKHPELFESLGIAQPKGVILYGPPGTGKTLLARAVAHHTDCKFIRVSGAELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRVEGGGSGGGDSEVQRTMLELLNQLDGFETSKNIKIIMATNRLDILDPALLRPGRIDRKIEFPPPTVAARAEILRIHSRKMNLTRGINLRKIAEKMNGCSGADVKGVCTEAGMYALRERRIHVTQEDFELAVGKVMNKNQETAISEAKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWA0</accession>
    <name>Q6FWA0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0D01804g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWA0"/>
    <dbReference type="FunCoup" id="Q6FWA0">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWA0"/>
    <dbReference type="KEGG" id="cgr:2887038"/>
    <dbReference type="CGD" id="CAL0128205">
        <property type="gene designation" value="CAGL0D01804g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01804g"/>
    <dbReference type="eggNOG" id="ENOG502QRZ0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031639_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWA0"/>
    <dbReference type="OMA" id="WPRFYGW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06817">
        <property type="entry name" value="PLPDE_III_DSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="14">
        <location>
            <begin position="306"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0128205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG58405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="427" mass="47984" checksum="AD354B6D9F341E75" modified="2004-07-19" version="1">MKEYPEEYLGQHISTLPTPCMVIDEKKFNSNCENMLKHVGELGSLTEHPILFRAHVKTHKTTEGTLRQLGFEGTSAPFRSKAILVSTIKEAEGLLEYQDSINGVFVDDIAFSLPACVPEVLERLSSISTRVSNLRVFVDNIDHLENLKQFGRPKSGKKWSIFLKIDMGTSRAGLEVRSEEFKELVEKLCDESVKEVTQIFGLYAHAGHSYSSHDINEANGYLIDEITAVNEAAKLVGSVTEIEPRLLTLSVGATPTANSLSTKENKKLIDIIRNDLVAPLEIHCGNYPCYDLQQYSTKCIKLNKISAFVLASIVSKYEKRNEALINAGVLALARENSSIPGMGLCINTDKYLHAPRDFEVSSFVNRVSQEHGILQPYNRDKCEDWKLGEKLLVIPQHACITMAQFPYYFVFNDSGKVIDVWKPHQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWJ2</accession>
    <name>Q6FWJ2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3 11">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MET22</name>
        <name evidence="12 13" type="ordered locus">CAGL0C05247g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3 11"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445402.1">
        <property type="nucleotide sequence ID" value="XM_445402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWJ2"/>
    <dbReference type="FunCoup" id="Q6FWJ2">
        <property type="interactions" value="89"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWJ2"/>
    <dbReference type="GeneID" id="2886786"/>
    <dbReference type="KEGG" id="cgr:2886786"/>
    <dbReference type="CGD" id="CAL0127514">
        <property type="gene designation" value="MET22"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05247g"/>
    <dbReference type="eggNOG" id="KOG1528">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033446_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FWJ2"/>
    <dbReference type="OMA" id="MSYQQER"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052829">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042538">
        <property type="term" value="P:hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043647">
        <property type="term" value="P:inositol phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016078">
        <property type="term" value="P:tRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000015">
        <property type="entry name" value="3',5'-bisphosphate nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0127514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="357" mass="39193" checksum="3BC6A4E865800682" modified="2004-07-19" version="1">MAFERELLVATQAVRKASLLTRRIQADVIAHRDSTTITKSDSSPVTVGDFAAQTIIINAIKSNFPDDKIVGEESSDGLSDEFVSEILHQIKENDKIFDKQYNDSSIQFTSNEHPLSSLDDVRKVIDCGNYEGGNKGRFWCLDPIDGTKGFLRGDQFAVCLGLIIDGIVQVGCIGCPNLSLEKYGGSDLPGYKEFGYLFSAIKTQGAFYATCSTKVPDWKPIKVRQLKDTSEMISLEGVEKSHSSHDEQSQIKAKLGINNSLHLDSQVKYCLLALGLADVYLRLPIKLSYREKIWDHAAGNTIVLEAGGYHTDSMENLPLDFGKGRTLQTKGVIASSGPKDLHDLIVKTSADVINSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWL4</accession>
    <name>Q6FWL4_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0C04763g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445380.1">
        <property type="nucleotide sequence ID" value="XM_445380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWL4"/>
    <dbReference type="STRING" id="284593.Q6FWL4"/>
    <dbReference type="KEGG" id="cgr:2886940"/>
    <dbReference type="CGD" id="CAL0127288">
        <property type="gene designation" value="CAGL0C04763g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04763g"/>
    <dbReference type="eggNOG" id="KOG1688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052834_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWL4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0127288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="315" mass="37602" checksum="C8252ECDF87B7AB6" modified="2004-07-19" version="1">MLSLKPGATLVQKYKNLYQLCLDKCTAYTKVRWVAELSLVVLFLNRFVPLLDCYVYDSKLFDDLLIIFSCFTWGFLYDKLLQQEEGNLDVGEKLDDIHPILSRPPEFRIWYYCIGTTVYYILWELLIPPLPNWVGSLAFFLHSTYCLAYMFKVILQGENPTHQFYLDVCKRHTMARWISGIVLLFFVAFLYRCHYAWELCYYALGISILDAFIKYLRRMRDMYLQQCKDKSDQEANEAFREFRPYLRNSPEFILWCSCIKYTVWFLVLSLFNCLHDPDLFGLYVLIYDICWTVICVIKAILLMISYSTYQHRHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWR2</accession>
    <name>Q6FWR2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0C03575g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWR2"/>
    <dbReference type="STRING" id="284593.Q6FWR2"/>
    <dbReference type="KEGG" id="cgr:2886731"/>
    <dbReference type="CGD" id="CAL0127608">
        <property type="gene designation" value="CAGL0C03575g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03575g"/>
    <dbReference type="eggNOG" id="ENOG502S8X9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_411023_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWR2"/>
    <dbReference type="OMA" id="ISEWEIN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274941" evidence="2">
        <location>
            <begin position="20"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="668" mass="70584" checksum="D3FE530296EDAD45" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWT2</accession>
    <name>Q6FWT2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">M7GpppX diphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0C03113g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms heterodimer with DCS2; the interaction inhibits the DCS1 scavenger decapping activity during post-diauxic growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIT family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWT2"/>
    <dbReference type="FunCoup" id="Q6FWT2">
        <property type="interactions" value="830"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWT2"/>
    <dbReference type="KEGG" id="cgr:2886807"/>
    <dbReference type="CGD" id="CAL0127272">
        <property type="gene designation" value="CAGL0C03113g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03113g"/>
    <dbReference type="eggNOG" id="KOG3969">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041045_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FWT2"/>
    <dbReference type="OMA" id="RAYFHYQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106095">
        <property type="term" value="C:m7G(5')pppN diphosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044692">
        <property type="term" value="F:exoribonuclease activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031086">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-independent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.40:FF:000002">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000015">
        <property type="entry name" value="m7GpppX diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.40">
        <property type="entry name" value="Scavenger mRNA decapping enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008594">
        <property type="entry name" value="DcpS/DCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011145">
        <property type="entry name" value="Scavenger_mRNA_decap_enz_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12978:SF0">
        <property type="entry name" value="M7GPPPX DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05652">
        <property type="entry name" value="DcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028973">
        <property type="entry name" value="Scavenger_mRNA_decap_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102860">
        <property type="entry name" value="mRNA decapping enzyme DcpS N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR028973-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0127272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="41735" checksum="2BEFB760D09A1946" modified="2004-07-19" version="1">MASKAQDKVSTMAESEDFSTLIERFQFVKVLDSNPQTKVISLLGTIDGKDAIITAEKTHFVFDETVHKTASDENATPIFYHCENEYSCVNGIEELKQITNNDIYYWGLSVLRQSMDYNPTAKLNLIWPATPVHVKKYEQQNFHLIKETPEAYKRIVEPYIEEMHNKGRLAWVNNILYGEAEADRVVYKDYQEDNKKDSFIVLPDMKWDGNNLESLYLVAISYRDDIRSLRDLKMEDRDWLKNIYNKIRSIIPACYNYAVHPDELRVFIHYQPSYYHFHIHIVNIKHPGLGNGISTGKAILLDEIIDMLQYLGPEGYMRKTITYVIGENHDLWKRGLEEEVSKQLEADGIPKLPNIVEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWU3</accession>
    <name>Q6FWU3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Tubulin-specific chaperone A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0C02849g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tubulin-folding protein; involved in the early step of the tubulin folding pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
            <location evidence="2 9">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TBCA family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWU3"/>
    <dbReference type="FunCoup" id="Q6FWU3">
        <property type="interactions" value="717"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWU3"/>
    <dbReference type="KEGG" id="cgr:2886896"/>
    <dbReference type="CGD" id="CAL0127582">
        <property type="gene designation" value="CAGL0C02849g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02849g"/>
    <dbReference type="eggNOG" id="KOG3470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130569_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FWU3"/>
    <dbReference type="OMA" id="EECEMMI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000010">
        <property type="entry name" value="Tubulin-specific chaperone A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004226">
        <property type="entry name" value="TBCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036126">
        <property type="entry name" value="TBCA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21500:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02970">
        <property type="entry name" value="TBCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46988">
        <property type="entry name" value="Tubulin chaperone cofactor A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0127582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="106" mass="12532" checksum="18D2CF62E7029146" modified="2004-07-19" version="1">MSPTQLEIKVKALQRLVKEEKYYLQELKDQKKHVDELKADSSVDKYDLKKQEEVLADTERLLPTLYVKIKEFQDNLEEYLNTYNGNEDTKEAKEAIETSKKLLSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWY1</accession>
    <name>Q6FWY1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0C02013g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWY1"/>
    <dbReference type="FunCoup" id="Q6FWY1">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWY1"/>
    <dbReference type="KEGG" id="cgr:2886794"/>
    <dbReference type="CGD" id="CAL0127188">
        <property type="gene designation" value="CAGL0C02013g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02013g"/>
    <dbReference type="eggNOG" id="KOG0756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FWY1"/>
    <dbReference type="OMA" id="TRMQSKY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF5">
        <property type="entry name" value="AFR253WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="99"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="232"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0127188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36796" checksum="85259EE0D44FB367" modified="2004-07-19" version="1">MTQNKVNDNVTLITAGSVSGLFSATITYPFEFLKTGLQLHRNVVAAKPFEVLGYQVRTYFAGCSAVNIGVVMKTSLRFLAFDKASEWLRPPALAKDAPLSGVQLLMAGALTGTMESLCIIPFENVKVAMIQNSLLSHERLNTTTSNVQGQVANEVKKTFHKKPTLRSSYEALFPEKLPTNVLTTAAELYRQHGLRAYFKGTMPTLMRQVGNSVVRFTTFTMLKQFAPKEYQNNEYFATLLGLISSCAVVGATQPLDVIKTRMQAKDSVLLYRNSINCAYRIFVEEGFAMLWKGWLPRLMKVGLSGSVSFGIYQYTENMIALMRQERYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWY6</accession>
    <name>Q6FWY6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anaphase-promoting complex subunit CDC27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0C01903g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWY6"/>
    <dbReference type="FunCoup" id="Q6FWY6">
        <property type="interactions" value="985"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWY6"/>
    <dbReference type="KEGG" id="cgr:2886773"/>
    <dbReference type="CGD" id="CAL0127292">
        <property type="gene designation" value="CAGL0C01903g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C01903g"/>
    <dbReference type="eggNOG" id="KOG1126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008850_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FWY6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="551"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="687"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="721"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0127292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="87785" checksum="7A17B9CD8FD21523" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX60</accession>
    <name>Q6FX60_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0B00550g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ADP + ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16577"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.7.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>sulfate + ADP + H(+) = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16529"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ATP adenylyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX60"/>
    <dbReference type="FunCoup" id="Q6FX60">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX60"/>
    <dbReference type="KEGG" id="cgr:2886638"/>
    <dbReference type="CGD" id="CAL0127712">
        <property type="gene designation" value="CAGL0B00550g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B00550g"/>
    <dbReference type="eggNOG" id="ENOG502QRAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049915_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FX60"/>
    <dbReference type="OMA" id="DPFENPP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008796">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004780">
        <property type="term" value="F:sulfate adenylyltransferase (ADP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.70:FF:000001">
        <property type="entry name" value="APA1p AP4A phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000846">
        <property type="entry name" value="ATP_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="15">
        <location>
            <begin position="192"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0127712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG57894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="318" mass="36328" checksum="B2424425B324EB08" modified="2004-07-19" version="1">MIPETVGSLIAQKYKSAKENDHLHFIETESKAIKDDDSGMNFVISYTPSLLKKPERADAQKDGTDPFEKPEPELTILEDLNEDGQFKLLLNKFPVIANHTLLVTKEFKHQNTALTPPELMVAYKLLCTLDKTESKRHMVFYNSGPQSGSSQDHKHLQMLALPEDFVPFQDNLCAGKPHFLPDFKTEPLQDDKVSFAHYVLPMPEDSDSVDEDLMAMCYISLLQRALTFFQDWTNEKPNMEKSYNFLLTKKWICLIPRFRTQAESLEIGFNAVGYAGLVLVKKEDVFQKITEKPELINDVLLECGFPNTAGTKPTEYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="151" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXI1</accession>
    <accession>Q5YB66</accession>
    <name>Q6FXI1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase STE11</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">STE11</name>
        <name evidence="18 19" type="ordered locus">CAGL0B02739g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it phosphorylates the STE7 protein kinase which itself, phosphorylates the FUS3 and or KSS1 kinases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445090.1">
        <property type="nucleotide sequence ID" value="XM_445090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXI1"/>
    <dbReference type="FunCoup" id="Q6FXI1">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXI1"/>
    <dbReference type="GeneID" id="2886703"/>
    <dbReference type="KEGG" id="cgr:2886703"/>
    <dbReference type="CGD" id="CAL0127090">
        <property type="gene designation" value="STE11"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B02739g"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003051_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FXI1"/>
    <dbReference type="OMA" id="CFNADSI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032093">
        <property type="term" value="F:SAM domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071507">
        <property type="term" value="P:pheromone response MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000272">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="389"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0127090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG57990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="676" mass="76198" checksum="0B9AD5EBC9F43F69" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXL0</accession>
    <name>Q6FXL0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0B04939g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXL0"/>
    <dbReference type="FunCoup" id="Q6FXL0">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXL0"/>
    <dbReference type="KEGG" id="cgr:2886686"/>
    <dbReference type="CGD" id="CAL0127032">
        <property type="gene designation" value="CAGL0B04939g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04939g"/>
    <dbReference type="eggNOG" id="ENOG502R0JC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035072_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXL0"/>
    <dbReference type="OMA" id="DWIRYIN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055011">
        <property type="entry name" value="Tag1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055010">
        <property type="entry name" value="Tag1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055012">
        <property type="entry name" value="Tag1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22786">
        <property type="entry name" value="Tag1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22787">
        <property type="entry name" value="Tag1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20775">
        <property type="entry name" value="Tag1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 N-terminal" evidence="3">
        <location>
            <begin position="71"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 middle barrel-like" evidence="5">
        <location>
            <begin position="262"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 C-terminal" evidence="4">
        <location>
            <begin position="491"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0127032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="600" mass="68914" checksum="46E60A3B6C4B1D78" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY15</accession>
    <name>Q6FY15_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HXT5</name>
        <name evidence="12 13" type="ordered locus">CAGL0A01826g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57738.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444845.2">
        <property type="nucleotide sequence ID" value="XM_444845.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY15"/>
    <dbReference type="FunCoup" id="Q6FY15">
        <property type="interactions" value="1319"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY15"/>
    <dbReference type="GeneID" id="2886476"/>
    <dbReference type="KEGG" id="cgr:2886476"/>
    <dbReference type="CGD" id="CAL0126791">
        <property type="gene designation" value="HXT5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01826g"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="Q6FY15"/>
    <dbReference type="OMA" id="VMVVFAC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005353">
        <property type="term" value="F:fructose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015578">
        <property type="term" value="F:mannose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904659">
        <property type="term" value="P:D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="86"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0126791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG57738.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="588" mass="65689" checksum="A13A1B93F48E6050" modified="2008-09-23" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>B4UMZ9</accession>
    <name>B4UMZ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0F06693g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAR58023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UMZ9"/>
    <dbReference type="FunCoup" id="B4UMZ9">
        <property type="interactions" value="710"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UMZ9"/>
    <dbReference type="KEGG" id="cgr:9487988"/>
    <dbReference type="CGD" id="CAL0131060">
        <property type="gene designation" value="CAGL0F06693g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06693g"/>
    <dbReference type="eggNOG" id="KOG3480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162151_1_0_1"/>
    <dbReference type="InParanoid" id="B4UMZ9"/>
    <dbReference type="OMA" id="VGENMQK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11038:SF16">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="14">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0131060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAR58023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="93" mass="10205" checksum="C81A20B896724897" modified="2008-09-23" version="1">MSFLGLGGGAPQLSSQQKIQAAEAELDLVTDMFNRLVSNCYTKCINNAYNEGDLNKNEANCLDRCVAKYFETNVKVGENMQKLGQTFNAAGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN17</accession>
    <name>B4UN17_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0I06457g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAR58033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002999560.1">
        <property type="nucleotide sequence ID" value="XM_002999514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN17"/>
    <dbReference type="FunCoup" id="B4UN17">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UN17"/>
    <dbReference type="KEGG" id="cgr:9488011"/>
    <dbReference type="CGD" id="CAL0132582">
        <property type="gene designation" value="CAGL0I06457g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06457g"/>
    <dbReference type="eggNOG" id="ENOG502S504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115063_1_0_1"/>
    <dbReference type="InParanoid" id="B4UN17"/>
    <dbReference type="OMA" id="LNAWSCV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026770">
        <property type="entry name" value="RNase_K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31733">
        <property type="entry name" value="RIBONUCLEASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0132582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAR58033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="85" mass="9373" checksum="54DF17CEB3A473FD" modified="2008-09-23" version="1">MNPVVSSGKAWFCTILSAFGVVILSVIAHLFNTNHESFVGSINDPEDGPAVAKTVYLAALVYLVFFVFCGFQAYLSTRRRSIKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-31" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>F2Z629</accession>
    <name>F2Z629_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0B01203g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F2Z629"/>
    <dbReference type="FunCoup" id="F2Z629">
        <property type="interactions" value="534"/>
    </dbReference>
    <dbReference type="STRING" id="284593.F2Z629"/>
    <dbReference type="KEGG" id="cgr:2886683"/>
    <dbReference type="CGD" id="CAL0127910">
        <property type="gene designation" value="CAGL0B01203g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01203g"/>
    <dbReference type="eggNOG" id="KOG3475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150908_2_1_1"/>
    <dbReference type="InParanoid" id="F2Z629"/>
    <dbReference type="OMA" id="RMAYLKH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003214">
        <property type="entry name" value="PRK04179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0127910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG57922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="88" mass="9891" checksum="C39A3A9361EEB049" modified="2011-05-31" version="1">MGKGTPSFGKRHNKSHTLCNRCGRRSFHVQKKTCASCGYPSAKTRSYNWGQKAKRRHTTGTGRMRYLKHVARRFKNGFQSGTASKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-31" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>F2Z659</accession>
    <name>F2Z659_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mating factor alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MFalpha</name>
        <name evidence="4 5" type="ordered locus">CAGL0H03135g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F2Z659"/>
    <dbReference type="FunCoup" id="F2Z659">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="284593.F2Z659"/>
    <dbReference type="KEGG" id="cgr:2888712"/>
    <dbReference type="CGD" id="CAL0131914">
        <property type="gene designation" value="MFalpha"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03135g"/>
    <dbReference type="eggNOG" id="ENOG502S0T3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136956_0_0_1"/>
    <dbReference type="InParanoid" id="F2Z659"/>
    <dbReference type="OMA" id="AEAKWGW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000772">
        <property type="term" value="F:mating pheromone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007618">
        <property type="term" value="P:mating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016326">
        <property type="entry name" value="Mating_factor_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008675">
        <property type="entry name" value="Mating_factor_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05436">
        <property type="entry name" value="MF_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001866">
        <property type="entry name" value="Mating_factor_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0588">Pheromone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003293693" description="Mating factor alpha" evidence="2">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Mating factor alpha precursor N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0131914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="159" mass="17787" checksum="E467214D9CFF738A" modified="2011-05-31" version="1">MRFLRFISTVALLITGLATAQPVGEELGETVEVPSEAFIGYLDFGATNDVAILPISNKTNNGLLFVNTTLYNQATKGEKLSDFTKRDANPDAEAEAWHWVKIRKGQGLFRRSADASPEAEAWHWVRLRKGQGLFRRSADASPEAEAWHWVRLRKGQGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-31" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F2Z6E2</accession>
    <name>F2Z6E2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0J02156g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447799.1">
        <property type="nucleotide sequence ID" value="XM_447799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F2Z6E2"/>
    <dbReference type="FunCoup" id="F2Z6E2">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="284593.F2Z6E2"/>
    <dbReference type="KEGG" id="cgr:2889790"/>
    <dbReference type="CGD" id="CAL0132918">
        <property type="gene designation" value="CAGL0J02156g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02156g"/>
    <dbReference type="eggNOG" id="KOG0511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022885_2_0_1"/>
    <dbReference type="InParanoid" id="F2Z6E2"/>
    <dbReference type="OMA" id="EGARCIY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="274"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0132918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="500" mass="58115" checksum="55B49278EBFC4B7C" modified="2011-05-31" version="1">MVEGSATSIDPRFAELCMACRVGDIENADRLISTGININSVDEYDNSPLFLASLCGHEEVVKLLLERGAACDRDKFEGARCIYGALTDSIRDILLSHDISKAVDLNQPFATHISSLIRDFWFFMTFDLTIDFSKEDINFKAHKFLLNILCPEFFDSNWLCDNDSIDLSSVTDSATFEYFLGYAYLLPAVHKLSHRDYDELIKFSEVTKLHILTEFLHQSRTTYDAAEKSTLVMDFQFKFREYLREALKVFVEDKIINNYEENLNNITNKCLAFHDIYLRVQNHDTQVRYYPCHLAILERAPLFQLVFNSNFREKSVYISKSEYNDSITVNFPNCDFNVVEIILRYLYYDCPEIPIEYAAETVVMADILLEDRLKAIATANLVKSKSVFDYYSVFDILKLGWEMRSEKLEHFAAKEIAENLFKYEEDQNLKQAILESSQRISARQETDTIELVDDIRYYLVSSFVTNVNSDIVEEEDYENIEYQKRIAVVNKILRQLNIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIJ9</accession>
    <name>Q6FIJ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FKS3</name>
        <name evidence="14 15" type="ordered locus">CAGL0M13827g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449945.1">
        <property type="nucleotide sequence ID" value="XM_449945.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q6FIJ9"/>
    <dbReference type="FunCoup" id="Q6FIJ9">
        <property type="interactions" value="171"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIJ9"/>
    <dbReference type="CAZy" id="GT48">
        <property type="family name" value="Glycosyltransferase Family 48"/>
    </dbReference>
    <dbReference type="GeneID" id="2891236"/>
    <dbReference type="KEGG" id="cgr:2891236"/>
    <dbReference type="CGD" id="CAL0137469">
        <property type="gene designation" value="FKS3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13827g"/>
    <dbReference type="eggNOG" id="KOG0916">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000844_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FIJ9"/>
    <dbReference type="OMA" id="LWFWITV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF15">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="618"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1264"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1319"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1355"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1413"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1439"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1525"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1568"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1610"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1639"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1711"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1764"/>
            <end position="1788"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="237"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1814"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0137469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG62925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1840" mass="213290" checksum="B2E5C1081EDC7A52" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIT4</accession>
    <name>Q6FIT4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Kinetochore-associated protein MTW1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0M11924g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIT4"/>
    <dbReference type="FunCoup" id="Q6FIT4">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIT4"/>
    <dbReference type="KEGG" id="cgr:2891255"/>
    <dbReference type="CGD" id="CAL0136405">
        <property type="gene designation" value="CAGL0M11924g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11924g"/>
    <dbReference type="eggNOG" id="ENOG502S72R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046437_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIT4"/>
    <dbReference type="OMA" id="CTQAMET"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0136405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29690" checksum="6E9B2070D43297D8" modified="2004-07-19" version="1">MSAPSLRSTSVLTEHLEYPPVSLVDDIINAVNETMYKCTSAMEKYLLDRSEVDGVSYEEEIRVGVAKLESLMESAVDRNFDKLELYVLRNVLRVPEELLDAGVFRLKHQVDLEVVDPKLQHQVEIELEDKVRELETAFETHAQLKKKVRDLKTVAQRLNRFEDLLVRFVKEQGDDAEGVLRSLRPLDDTLKLLVLQLKRLYIESEENCSMDKVNTVVESTRQNGYRPNSSRTKYIDASADMVLEKLLHPTETDTSHKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIU2</accession>
    <name>HOG1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitogen-activated protein kinase HOG1</fullName>
            <shortName>MAP kinase HOG1</shortName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HOG1</name>
        <name type="ordered locus">CAGL0M11748g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Proline-directed serine/threonine-protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Activated by tyrosine and threonine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Dually phosphorylated on Thr-174 and Tyr-176, which activates the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449852.1">
        <property type="nucleotide sequence ID" value="XM_449852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIU2"/>
    <dbReference type="SMR" id="Q6FIU2"/>
    <dbReference type="FunCoup" id="Q6FIU2">
        <property type="interactions" value="802"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIU2"/>
    <dbReference type="EnsemblFungi" id="CAGL0M11748g-T">
        <property type="protein sequence ID" value="CAGL0M11748g-T-p1"/>
        <property type="gene ID" value="CAGL0M11748g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891247"/>
    <dbReference type="KEGG" id="cgr:2891247"/>
    <dbReference type="CGD" id="CAL0136993">
        <property type="gene designation" value="HOG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M11748g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11748g"/>
    <dbReference type="eggNOG" id="KOG0660">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q6FIU2"/>
    <dbReference type="OMA" id="NRYTDLN"/>
    <dbReference type="PHI-base" id="PHI:4625"/>
    <dbReference type="PHI-base" id="PHI:8395"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007231">
        <property type="term" value="P:osmosensory signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033262">
        <property type="term" value="P:regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000050">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000186329" description="Mitogen-activated protein kinase HOG1">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TXY">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5 6">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="29"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P32485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q16539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q4WSF6"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="447" mass="50111" checksum="9721E7EC5C05EF4F" modified="2004-07-19" version="1">MATNEEFIRTQIFGTVFEITNRYSDLNPVGMGAFGLVCSATDTLTNQQVAIKKIMKPFATAVLAKRTYRELKLLKHLRHENLICLQDIFLSPLEDIYFVTELQGTDLHRLLQTRPLEKQFVQYFHYQILRGLKYVHSAGVVHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFPGKDHVHQFSIITDLLGSPPSDVIDTICSENTLKFVTSLPHRDPIPFSERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPYLAPYHDPTDEPVAEAKFDWHFNDADLPVDTWRVMMYSEILDFHKIGGTDGQIDTSATFDDQVAAATVAAAQAQAHALAQAQMSQNMIDPNQLLNEDGTPVSGSIAENSSNSATTNLNGAAAGMNSASDTINEYANQAVHFANEFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ23</accession>
    <name>Q6FJ23_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CTS1</name>
        <name evidence="18 19" type="ordered locus">CAGL0M09779g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449771.1">
        <property type="nucleotide sequence ID" value="XM_449771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ23"/>
    <dbReference type="SMR" id="Q6FJ23"/>
    <dbReference type="FunCoup" id="Q6FJ23">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ23"/>
    <dbReference type="CAZy" id="CBM19">
        <property type="family name" value="Carbohydrate-Binding Module Family 19"/>
    </dbReference>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="GeneID" id="2891335"/>
    <dbReference type="KEGG" id="cgr:2891335"/>
    <dbReference type="CGD" id="CAL0136945">
        <property type="gene designation" value="CTS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09779g"/>
    <dbReference type="eggNOG" id="KOG4701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007818_7_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ23"/>
    <dbReference type="OMA" id="GTTCFAY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000125">
        <property type="entry name" value="CTS1p Endochitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005089">
        <property type="entry name" value="CBM19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03427">
        <property type="entry name" value="CBM_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274606" description="chitinase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="17">
        <location>
            <begin position="24"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="310"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="310"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0136945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG62749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="517" mass="54604" checksum="FDC8E5D938597270" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJA1</accession>
    <name>Q6FJA1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial protein PET191</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M07986g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJA1"/>
    <dbReference type="FunCoup" id="Q6FJA1">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJA1"/>
    <dbReference type="KEGG" id="cgr:2891745"/>
    <dbReference type="CGD" id="CAL0136419">
        <property type="gene designation" value="CAGL0M07986g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07986g"/>
    <dbReference type="eggNOG" id="KOG4114">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138069_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FJA1"/>
    <dbReference type="OMA" id="FLECKRG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0136419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12318" checksum="51937366594B1C56" modified="2004-07-19" version="1">MGASCKDQKRAVAICLQRSPCVMIERHKPQECLDNPELSKDLPELCIAQMKAFLDCKRGMVDMTKRFRGNAPLSTGKYDQQYDKLCSGDFNPREEMNKLNTLNSSEKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-01-04" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJI3</accession>
    <name>HSP7F_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Heat shock protein homolog SSE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SSE1</name>
        <name type="ordered locus">CAGL0M06083g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJI3"/>
    <dbReference type="SMR" id="Q6FJI3"/>
    <dbReference type="FunCoup" id="Q6FJI3">
        <property type="interactions" value="1361"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJI3"/>
    <dbReference type="EnsemblFungi" id="CAGL0M06083g-T">
        <property type="protein sequence ID" value="CAGL0M06083g-T-p1"/>
        <property type="gene ID" value="CAGL0M06083g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891659"/>
    <dbReference type="CGD" id="CAL0136515">
        <property type="gene designation" value="SSE1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M06083g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06083g"/>
    <dbReference type="eggNOG" id="KOG0103">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FJI3"/>
    <dbReference type="OMA" id="WEQSPEI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000020">
        <property type="entry name" value="Heat shock SSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000078393" description="Heat shock protein homolog SSE1">
        <location>
            <begin position="1"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="694" mass="77366" checksum="9868B6F66F9E3049" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJK0</accession>
    <name>Q6FJK0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCA7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SGF73</name>
        <name evidence="3 4" type="ordered locus">CAGL0M05709g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449594.1">
        <property type="nucleotide sequence ID" value="XM_449594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJK0"/>
    <dbReference type="FunCoup" id="Q6FJK0">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJK0"/>
    <dbReference type="GeneID" id="2891642"/>
    <dbReference type="KEGG" id="cgr:2891642"/>
    <dbReference type="CGD" id="CAL0137459">
        <property type="gene designation" value="SGF73"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05709g"/>
    <dbReference type="eggNOG" id="KOG4140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032226_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJK0"/>
    <dbReference type="OMA" id="EHQTKIG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
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        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046822">
        <property type="term" value="P:regulation of nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905634">
        <property type="term" value="P:regulation of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904802">
        <property type="term" value="P:RITS complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013243">
        <property type="entry name" value="SCA7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037804">
        <property type="entry name" value="SGF73"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041251">
        <property type="entry name" value="Znf_C2H2_13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47805:SF1">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08313">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18508">
        <property type="entry name" value="zf_C2H2_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51505">
        <property type="entry name" value="SCA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCA7" evidence="2">
        <location>
            <begin position="173"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="536" mass="59707" checksum="AB725CD6E90CF061" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJW3</accession>
    <name>Q6FJW3_CANGA</name>
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        <recommendedName>
            <fullName evidence="15 16">tRNA ligase</fullName>
            <ecNumber evidence="1 16">6.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22" type="ordered locus">CAGL0M03091g</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">One of the two proteins required for the splicing of precursor tRNA molecules containing introns. The ligation activity requires three enzymatic activities: phosphorylation of the 5' terminus of the 3' half-tRNA in the presence of ATP, opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester and ligation of the two tRNA halves in an ATP-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the TRL1 family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.3" evidence="1 16"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJW3"/>
    <dbReference type="FunCoup" id="Q6FJW3">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJW3"/>
    <dbReference type="KEGG" id="cgr:2891489"/>
    <dbReference type="CGD" id="CAL0137473">
        <property type="gene designation" value="CAGL0M03091g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03091g"/>
    <dbReference type="eggNOG" id="ENOG502QQB9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010316_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FJW3"/>
    <dbReference type="OMA" id="FHITLCH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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    </dbReference>
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        <property type="term" value="F:endonuclease activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity"/>
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        <property type="term" value="P:positive regulation of translation in response to stress"/>
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        <property type="term" value="P:regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
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        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="tRNA ligase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="T4-Rnl1-like_N"/>
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        <property type="entry name" value="Trl1_fun"/>
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        <property type="entry name" value="tRNA_lig_kin_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015965">
        <property type="entry name" value="tRNA_lig_PDEase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32004:SF1">
        <property type="entry name" value="TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09511">
        <property type="entry name" value="RNA_lig_T4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08302">
        <property type="entry name" value="tRNA_lig_CPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08303">
        <property type="entry name" value="tRNA_lig_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA_lig_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 16" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="T4 RNA ligase 1-like N-terminal" evidence="20">
        <location>
            <begin position="61"/>
            <end position="288"/>
        </location>
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    <feature type="domain" description="tRNA ligase kinase" evidence="19">
        <location>
            <begin position="389"/>
            <end position="556"/>
        </location>
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    <feature type="domain" description="tRNA ligase phosphodiesterase" evidence="18">
        <location>
            <begin position="561"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="17">
        <location>
            <position position="110"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00012724"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00034038"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR019634-50"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF08302"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08303"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF09511"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0137473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG62457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="830" mass="96238" checksum="38765F9F9FD0A4C5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJY4</accession>
    <name>Q6FJY4_CANGA</name>
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        <recommendedName>
            <fullName evidence="8">GLC7-interacting protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0M02607g</name>
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    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAG62436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene designation" value="CAGL0M02607g"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QYHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007231_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJY4"/>
    <dbReference type="OMA" id="KWGFFVQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF30">
        <property type="entry name" value="GLC7-INTERACTING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="95"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
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            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0136963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1204" mass="134636" checksum="85143A25F455F51D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJZ6</accession>
    <name>ATG5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATG5</name>
        <name type="ordered locus">CAGL0M02343g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Conjugated with ATG12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Conjugated to ATG12; which is essential for autophagy.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449448.1">
        <property type="nucleotide sequence ID" value="XM_449448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJZ6"/>
    <dbReference type="SMR" id="Q6FJZ6"/>
    <dbReference type="FunCoup" id="Q6FJZ6">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJZ6"/>
    <dbReference type="EnsemblFungi" id="CAGL0M02343g-T">
        <property type="protein sequence ID" value="CAGL0M02343g-T-p1"/>
        <property type="gene ID" value="CAGL0M02343g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891456"/>
    <dbReference type="KEGG" id="cgr:2891456"/>
    <dbReference type="CGD" id="CAL0136227">
        <property type="gene designation" value="CAGL0M02343g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02343g"/>
    <dbReference type="eggNOG" id="KOG2976">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051894_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FJZ6"/>
    <dbReference type="OMA" id="SIQKAVW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120095">
        <property type="term" value="C:vacuole-isolation membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140355">
        <property type="term" value="F:cargo receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051365">
        <property type="term" value="P:cellular response to potassium ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.190">
        <property type="entry name" value="Autophagy protein Apg5, helix rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007239">
        <property type="entry name" value="Atg5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048940">
        <property type="entry name" value="ATG5_HBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042526">
        <property type="entry name" value="Atg5_HR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048939">
        <property type="entry name" value="ATG5_UblA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042527">
        <property type="entry name" value="Atg5_UblA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13040:SF2">
        <property type="entry name" value="AUTOPHAGY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20637">
        <property type="entry name" value="ATG5_HBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20638">
        <property type="entry name" value="ATG5_UblA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000219001" description="Autophagy protein 5">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ATG12)" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="270" mass="30757" checksum="D45BD12B09C4D791" modified="2004-07-19" version="1">MGDSKELVWNGSINVQIKLDSRLLVDGVPEGRRLVNIRVPRESHIAIYTPLVLERLRNVLRSDIEELLPKVWYSYKDISLPWSIPFGTLFDIYNGAHKGISGSRDNYINVWKLNLVTDEKFPINVIPIIEGQDQLRKFMMQSWKQCCFILNGSSKRVMSLSLQDSLEVWEGVTERDYAKYSGVIKRILPRTPRRIPVAIHAANGGPIVQTTEPTLTDTSFSQAVEGIVKADFVVCQGIVMYLRDFSDTSLYDVYDKLHSIDGYLHLIANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK14</accession>
    <name>Q6FK14_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA repair and recombination protein RDH54</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">RAD homolog 54</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Recombination factor TID1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Two hybrid interaction with DMC1 protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26 27" type="ordered locus">CAGL0M01958g</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Involved in the recombinational repair of double-strand breaks (DSB) in DNA during mitosis and meiosis. Has DNA dependent ATPase activity. Promotes D-loop (displacement loop) formation with RAD51 recombinase. Modifies the topology of double-stranded DNA during the D-loop reaction to facilitate the invasion of the homologous duplex molecule by the initiating single-stranded DNA substrate. Required for adaptation from G2/M checkpoint arrest induced by a double strand break, by participating in monitoring the extent of single-stranded DNA produced by resection of DNA ends. This role is distinct from its roles in recombination. Promotes colocalization of RAD51 and DMC1 during meiotic recombination. Involved in crossover interference.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with RAD51 and DMC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK14"/>
    <dbReference type="FunCoup" id="Q6FK14">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK14"/>
    <dbReference type="KEGG" id="cgr:2891756"/>
    <dbReference type="CGD" id="CAL0136371">
        <property type="gene designation" value="CAGL0M01958g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01958g"/>
    <dbReference type="eggNOG" id="KOG0390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_10_1_1"/>
    <dbReference type="InParanoid" id="Q6FK14"/>
    <dbReference type="OMA" id="FTIMYRK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032392">
        <property type="term" value="P:DNA geometric change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030491">
        <property type="term" value="P:heteroduplex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000058">
        <property type="entry name" value="RDH54p DNA-dependent ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="301"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="25">
        <location>
            <begin position="635"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00072543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="CGD" id="CAL0136371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="CAG62406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="920" mass="104142" checksum="06439807CE121859" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKH2</accession>
    <name>Q6FKH2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 19">Serine/threonine-protein kinase RIO1</fullName>
            <ecNumber evidence="4 19">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25 26" type="ordered locus">CAGL0L11594g</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 19"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKH2"/>
    <dbReference type="FunCoup" id="Q6FKH2">
        <property type="interactions" value="1090"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKH2"/>
    <dbReference type="KEGG" id="cgr:2890972"/>
    <dbReference type="CGD" id="CAL0135814">
        <property type="gene designation" value="CAGL0L11594g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11594g"/>
    <dbReference type="eggNOG" id="KOG2270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FKH2"/>
    <dbReference type="OMA" id="HPMSLDF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030874">
        <property type="term" value="C:nucleolar chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016479">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090234">
        <property type="term" value="P:regulation of kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000755">
        <property type="entry name" value="Homoserine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017407">
        <property type="entry name" value="Ser/Thr_kinase_Rio1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038147">
        <property type="entry name" value="Ser/Thr_PK_RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="24">
        <location>
            <begin position="45"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="416"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="418"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="456"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR038147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR038147-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="CGD" id="CAL0135814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="CAG62246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="507" mass="59178" checksum="19BE367692B7A9AD" modified="2004-07-19" version="1">MDDLSDKFRNVKVSTDHINNQIMDKYGHKIKTDELSINKAKTNKDKANRATVENVLDPRTMRFLNALVNRGVIAGLNGCLSTGKEANVYHAFAGSKMATEQQSDEPKEDIDANAIPSKGNIDISENRAKTAEDLIREGRKEYAIKIYKTSILIFKDRERYVDGEFRFRNSRSQHNPRKMIKIWAEKEFRNLKRIYQMGVIPSPEPIEVKNNVLVMEFLNRGDGFASPKLRDYPYKDREEIYYYYHILVSYMRLLYQVCRLVHADLSEYNTIVHKEKLYMIDVSQSVEPEHPMSLDFLRMDIKNVNLYFEKMGIEIFQEKAIFQFVITDTLDKFDGDMNSYEDLRKYVATNIPIKRTQEDEAEDEVFRSLHLVRNLEGLEERDFDRFTDGKFDLLKSLLAQDNKKNYIAAQASKINVDSSDENISDSEDEGSDDGSDDDTDGSDEEEQYSEAESYEEVPKELKGKKYEDKDLKKQRKQEAKEAKREKRKTKVKKHIKKKLVNKTKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKP6</accession>
    <name>Q6FKP6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">CAGL0L09801g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449198.2">
        <property type="nucleotide sequence ID" value="XM_449198.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKP6"/>
    <dbReference type="FunCoup" id="Q6FKP6">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKP6"/>
    <dbReference type="KEGG" id="cgr:2891081"/>
    <dbReference type="eggNOG" id="KOG0530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026582_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKP6"/>
    <dbReference type="OMA" id="HRHTIID"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000009">
        <property type="entry name" value="CAAX geranylgeranyltransferase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG62168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="319" mass="37519" checksum="91E12A2983433A32" modified="2004-07-19" version="1">MLSWCAENFGDVEPMPIEMGSDELCKILYSDEYKLLLGLCRRLMSLGELSQRALLLTAKVIAIAPAFYTVWNYRYSIIKEQLSSLDKVEQGALVNKELDWLDEVTLSNPKNYQIWSYRQALLKVHPSPQLKRELPIIQLMIDEDTKNYHVWSYRKWCVLFFKDFNHELPFTDMMIRRDIYNNSAWTHRMFVWQHTESSSTQVIAEIDNYLRGKIELAPQNISCWTYLRGLYELFLHENYDPSIIRFAEGFIDGVLDSDSTAEKIETIESSYALEFLAHVYSRNPSTQEKALRAYQLLSDKFDPIRANLWQHKIKQLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL30</accession>
    <name>Q6FL30_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phosphate system positive regulatory protein PHO81</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PHO81</name>
        <name evidence="7 8" type="ordered locus">CAGL0L06622g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449064.1">
        <property type="nucleotide sequence ID" value="XM_449064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL30"/>
    <dbReference type="FunCoup" id="Q6FL30">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL30"/>
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        <property type="component" value="Chromosome L"/>
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        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
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        <property type="term" value="F:phosphoric diester hydrolase activity"/>
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        <property type="term" value="P:cellular response to phosphate starvation"/>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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        <property type="entry name" value="C2_GPCPD1"/>
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    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
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        <property type="entry name" value="SPX_dom"/>
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    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
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        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
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    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
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    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
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    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
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    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="411"/>
            <end position="435"/>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="446"/>
            <end position="472"/>
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        <location>
            <begin position="514"/>
            <end position="547"/>
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    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="549"/>
            <end position="581"/>
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    </feature>
    <feature type="domain" description="GP-PDE" evidence="6">
        <location>
            <begin position="816"/>
            <end position="1137"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
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    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62034.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
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    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1137" mass="127764" checksum="ADEC38551F20B95B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL92</accession>
    <name>Q6FL92_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MDH1</name>
        <name evidence="15 16" type="ordered locus">CAGL0L05236g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449002.1">
        <property type="nucleotide sequence ID" value="XM_449002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL92"/>
    <dbReference type="SMR" id="Q6FL92"/>
    <dbReference type="FunCoup" id="Q6FL92">
        <property type="interactions" value="944"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL92"/>
    <dbReference type="GeneID" id="2890781"/>
    <dbReference type="KEGG" id="cgr:2890781"/>
    <dbReference type="CGD" id="CAL0136024">
        <property type="gene designation" value="MDH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05236g"/>
    <dbReference type="eggNOG" id="KOG1494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047181_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FL92"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="165"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="24"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0136024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG61972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="336" mass="35566" checksum="C661A1AA8C88502C" modified="2004-07-19" version="1">MLSRISRRAFSSTRINPYKVTVLGANGGIGQPLSLLLKLNQKVTDLRLYDLRGAPGVASDLSHIPTNSTVKGFTPEEADGLKNALKDTDLVLIPAGVPRKPGMTRDDLFAINAGIVRDLATAAAESAPNAAILVISNPVNSTVPIVAEVLQKKGVYNPKKLFGVTTLDSIRASRFISEVVGTDPTQEKVNVVGGHSGITIIPLLSQTKYGDKLDKDQKDALIKRIQFGGDEVVKAKNGAGSATLSMAQAGALFANAVLSGFAGEQNVVEPSFVDSPLYKGEGIEFFASPVTLGKEGVVKIHPIGTISAEEEEMLATCKETLKKNIEKGINFVKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLA3</accession>
    <name>Q6FLA3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Factor arrest protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0L04994g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLA3"/>
    <dbReference type="FunCoup" id="Q6FLA3">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLA3"/>
    <dbReference type="KEGG" id="cgr:2890716"/>
    <dbReference type="CGD" id="CAL0135422">
        <property type="gene designation" value="CAGL0L04994g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04994g"/>
    <dbReference type="eggNOG" id="ENOG502S56F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116422_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLA3"/>
    <dbReference type="OMA" id="ECRANRQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000321">
        <property type="term" value="P:re-entry into mitotic cell cycle after pheromone arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0135422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="24028" checksum="CC7631D56197EB63" modified="2004-07-19" version="1">MNEGSYDNFEYLNLLAKNLSVGCRDSRKETDKIELLLKRLSKQSVVSYEEFSQRPSEETLDAYKKLSEPTTTEQLIRENYQLMYEIEQQEYINKRIIALVNSINEHLISIRNFIIEQKLARDQNNEIYMHENFTVRENLLKNSTELLKAREQCSRTNTEVVVEKFKKLYAEIDWDTLPSNLPDIIQVKEKIKHIKETYKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLF2</accession>
    <name>Q6FLF2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0L03872g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLF2"/>
    <dbReference type="FunCoup" id="Q6FLF2">
        <property type="interactions" value="650"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLF2"/>
    <dbReference type="KEGG" id="cgr:2890545"/>
    <dbReference type="CGD" id="CAL0135526">
        <property type="gene designation" value="CAGL0L03872g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03872g"/>
    <dbReference type="eggNOG" id="KOG3438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FLF2"/>
    <dbReference type="OMA" id="MRIQMYD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000012">
        <property type="entry name" value="DNA-directed RNA polymerases I and III subunit RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="7">
        <location>
            <begin position="56"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0135526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="137" mass="15320" checksum="75AF15DD3185EC3A" modified="2004-07-19" version="1">MSTEERIAKAESEDVEMTNGGALENVEEEDIEDQEEESLKTKIKLLPQATSEDGTCASFQIAQEDHTLGNALRYIIMKNPEVEFCGYSIPHPSEELLNLRIQTYGNITAVDALQKGLDDLIDLCDAVKDKFVQRLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLG8</accession>
    <name>Q6FLG8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BCK1</name>
        <name evidence="9 10" type="ordered locus">CAGL0L03520g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448926.1">
        <property type="nucleotide sequence ID" value="XM_448926.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FLG8">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLG8"/>
    <dbReference type="GeneID" id="2890737"/>
    <dbReference type="KEGG" id="cgr:2890737"/>
    <dbReference type="CGD" id="CAL0135680">
        <property type="gene designation" value="BCK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03520g"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002516_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLG8"/>
    <dbReference type="OMA" id="PWSNFEV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010447">
        <property type="term" value="P:response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1151"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="780"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="816"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1180"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0135680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1447" mass="161958" checksum="4AA9D021E55F3C7A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLM6</accession>
    <name>Q6FLM6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein ECM9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">CAGL0L02255g</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61838.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLM6"/>
    <dbReference type="FunCoup" id="Q6FLM6">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLM6"/>
    <dbReference type="eggNOG" id="ENOG502RXS6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062497_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLM6"/>
    <dbReference type="OMA" id="NYYCWNT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF8">
        <property type="entry name" value="PROTEIN ECM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG61838.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="33744" checksum="87A87AFAFC7830A9" modified="2008-09-23" version="2">MAISQYIVNNDTYLATVGLLLTTPENKTIINLHYKCLLELCADDTKALQREVVYLQRLLSCTNNRINKSSSLWLLYKKLYIQFNKTITFNVNTTLIKSAENHFSNYYAWNFARWYYINTTIEERSSLLTRTRYFCNTHFKDSAAWSAFMFMLLPIDDSHEKFLAENCLTDSLDHKSQPLEQEFVEKEVRSVINRIDILQCPEWSPFALVLAATKHMRGCPLHDIFVKWKQEINQYEAQNDTIKFFHRQPMFDKNDTNILSRQLFMHIAYKKTLLDKLLMFNEVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM38</accession>
    <name>Q6FM38_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0K11297g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448706.1">
        <property type="nucleotide sequence ID" value="XM_448706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM38"/>
    <dbReference type="FunCoup" id="Q6FM38">
        <property type="interactions" value="1183"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM38"/>
    <dbReference type="KEGG" id="cgr:2890065"/>
    <dbReference type="CGD" id="CAL0134277">
        <property type="gene designation" value="CAGL0K11297g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11297g"/>
    <dbReference type="eggNOG" id="KOG3354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077168_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FM38"/>
    <dbReference type="OMA" id="YEGDDYH"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="8"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0134277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="183" mass="20443" checksum="859D65D7A04D9943" modified="2004-07-19" version="1">MTNHKLKVIVLAGTAGTGKSTVAARLLKEYSTKYPGIKFVEGDELHPKANIDKMASGNPLNDDDRWGWLKEVALKSAQSAEEGGCGVSVVACSSLKKSYRDLIRSTRPDVEYHFVFLYGSKVEILNRLNSRKGHFMKSNMMESQFKDLQLPEESEANCVVVLLDHKGFDEIEDDVLKYTNTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMF2</accession>
    <name>Q6FMF2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vacuolar aminopeptidase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">CAGL0K08536g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448592.2">
        <property type="nucleotide sequence ID" value="XM_448592.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMF2"/>
    <dbReference type="FunCoup" id="Q6FMF2">
        <property type="interactions" value="241"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMF2"/>
    <dbReference type="MEROPS" id="M18.001"/>
    <dbReference type="KEGG" id="cgr:2890319"/>
    <dbReference type="eggNOG" id="KOG2596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019532_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FMF2"/>
    <dbReference type="OMA" id="DWPIAKI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="509" mass="57005" checksum="DDD604FBE9BB6CF9" modified="2004-07-19" version="1">MEEQRQIIEQLKQTLNALTVSQNTTSNKTPADEPFYHINEHTYEDCAQEFIDFTYENPTTYHVIEFFSKLLEGKGFKYLPEKKTWNDELEPGKPGRYYTIRNGTNMTAWVIGKKWKPESGVGVVASHVDSLTAKLKPASLMEKVEGYKLFGVAPYGGTLNELWFDRDLGIAGRVLYKKKNSSKVESTLVNSAPHPIGRIPSLAPHFGQPSEGPFNKETQAVPFFGWCCDIDDEGTITDEEKKCPLVGKHSILLLRYIAELAGIKVSEILQLDLDLFDVQKGTFGGIKKDFIFSPRMDDRLCSFTAMIAMAYYGATVDLDELSSFNMVALFDNEEVGSLTRQGAESTLLKTSICRTAKRFTNMEGLEPPTLFANSIVLSADVNHLFNPNFKEVYLKKHSPKPNWGMTISLDPNAHMATDVVGLAFVEELARKNKDTVQYFQIRNDSRSGGTVGPIVAAQLGARTIDVGISQLSMHSIRAATGTKDIAMAIKFFRGFFDNWREVYDNFGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMG5</accession>
    <name>Q6FMG5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0K08228g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMG5"/>
    <dbReference type="FunCoup" id="Q6FMG5">
        <property type="interactions" value="619"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMG5"/>
    <dbReference type="KEGG" id="cgr:2890347"/>
    <dbReference type="CGD" id="CAL0134921">
        <property type="gene designation" value="CAGL0K08228g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08228g"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012923_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FMG5"/>
    <dbReference type="OMA" id="YNLALFW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044395">
        <property type="term" value="P:protein targeting to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0134921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="433" mass="50340" checksum="7520C9622E387397" modified="2004-07-19" version="1">MGVATLFAELLNGCLAKYSALFSMLAMFMALYTILRHLMNYRKPYEQRLSIRILIVVPIFCITCLLSVLFPFYARRFVDPIREVYEAVVIYTFFSLLITYLGGEYEIISRRGLKHQPVNHFVPLVGQLLKKVDISNPNDFLWIKRGILQYVWFKPIYSISMICIDIWGLKQFEIALVVLFNISVSLSLYELALFWKCLYQDLLPFHPWPKFLCVKLIIFVSYWQGLIIQVLGYYRLLGKSIEYKHSELGYIYRNALLCFEMIGFAYLHQKAFPWEDYSIKSIPMGARMKLRYAIRDCFGIQDLIWDSKQALNGNTYYNYRNFDPSVETSLLGGVNRDTRIDRINEGLRFTNNGESRYWIDYGAIESGAQVSESIRNTDSAKDISADWDDSIDTSRYVQADPNYPVVWNIAGARYTNSTAQLRNEIIGRSSSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMI0</accession>
    <name>Q6FMI0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K07898g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448564.1">
        <property type="nucleotide sequence ID" value="XM_448564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMI0"/>
    <dbReference type="FunCoup" id="Q6FMI0">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890366"/>
    <dbReference type="CGD" id="CAL0133815">
        <property type="gene designation" value="CAGL0K07898g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07898g"/>
    <dbReference type="eggNOG" id="ENOG502QVZN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_674749_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMI0"/>
    <dbReference type="OMA" id="YFFVYSA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="480" mass="54128" checksum="C029F769D473C0C9" modified="2004-07-19" version="1">MSEQRPIRVAVLGGDSTGKTSFVSRLTLNIVHEVHYPTRDQTNWLFDFIPHSPVSRAILDAEAHERLAFRTPGSQVLEPIFSSPSVTDHVLLSPLVFQAFTDEFTQVRNQNKGRTLSYIRPMESSKKKKPHLYKYSYNNGKAAEANDKGIYLRGPTFMEKSPNNELPVNYVPPVYSPILIDIIDTPGFKPDMVVPFLEVSLFANLDKNILRGLADEPRQPVSTTSLLVASGASELNGKIDGYVFVYSAIPELSHLISPPSYDFSNTNKDVANLSIDKTKTNESIPWSSYTKKKDGGFSLLDVIRDCILDAWAEFRDYQRRWEMGQEDDVYSLFYTLKHMWKAEKDRSTKIQELRSYKTTLNSIETDPSSPDSPPPCLIVCTHTKDNMASPLLIEKGRQLATQWKCGFVALDNLEDYNVDVALSLLIREIAEKEKLQIGRGNKMHQSIGKDHSLHPSKSNPNNTESSSSGAVSMFKKFLRN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FML5</accession>
    <name>PRP5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-processing ATP-dependent RNA helicase PRP5</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PRP5</name>
        <name type="ordered locus">CAGL0K07029g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448529.1">
        <property type="nucleotide sequence ID" value="XM_448529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FML5"/>
    <dbReference type="SMR" id="Q6FML5"/>
    <dbReference type="FunCoup" id="Q6FML5">
        <property type="interactions" value="1144"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FML5"/>
    <dbReference type="EnsemblFungi" id="CAGL0K07029g-T">
        <property type="protein sequence ID" value="CAGL0K07029g-T-p1"/>
        <property type="gene ID" value="CAGL0K07029g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890388"/>
    <dbReference type="KEGG" id="cgr:2890388"/>
    <dbReference type="CGD" id="CAL0134379">
        <property type="gene designation" value="CAGL0K07029g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07029g"/>
    <dbReference type="eggNOG" id="KOG0334">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FML5"/>
    <dbReference type="OMA" id="FAQYVHT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000348">
        <property type="term" value="P:mRNA branch site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22474">
        <property type="entry name" value="KH-I_PRP5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000232360" description="Pre-mRNA-processing ATP-dependent RNA helicase PRP5">
        <location>
            <begin position="1"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="283"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="490"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="251"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="410"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="296"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="816" mass="92283" checksum="13ECEE42B733164C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMM0</accession>
    <name>Q6FMM0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MCX1</name>
        <name evidence="6 7" type="ordered locus">CAGL0K06919g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448524.1">
        <property type="nucleotide sequence ID" value="XM_448524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMM0"/>
    <dbReference type="FunCoup" id="Q6FMM0">
        <property type="interactions" value="694"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMM0"/>
    <dbReference type="GeneID" id="2890412"/>
    <dbReference type="KEGG" id="cgr:2890412"/>
    <dbReference type="CGD" id="CAL0134939">
        <property type="gene designation" value="MCX1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06919g"/>
    <dbReference type="eggNOG" id="KOG0745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FMM0"/>
    <dbReference type="OMA" id="HRSDFTN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="168"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="5">
        <location>
            <begin position="399"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0134939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="549" mass="60972" checksum="DED2F9062BB63A68" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMU1</accession>
    <name>Q6FMU1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0K05247g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMU1"/>
    <dbReference type="STRING" id="284593.Q6FMU1"/>
    <dbReference type="KEGG" id="cgr:2890511"/>
    <dbReference type="CGD" id="CAL0133941">
        <property type="gene designation" value="CAGL0K05247g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05247g"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006239_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMU1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="725"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1146"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1224" mass="136106" checksum="F9453AAE0FFB06B3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMV2</accession>
    <name>Q6FMV2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphorelay intermediate protein YPD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">YPD1</name>
        <name evidence="11 12" type="ordered locus">CAGL0K04961g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YPD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448442.1">
        <property type="nucleotide sequence ID" value="XM_448442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMV2"/>
    <dbReference type="FunCoup" id="Q6FMV2">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMV2"/>
    <dbReference type="GeneID" id="2890498"/>
    <dbReference type="KEGG" id="cgr:2890498"/>
    <dbReference type="CGD" id="CAL0134677">
        <property type="gene designation" value="YPD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04961g"/>
    <dbReference type="eggNOG" id="KOG4747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085158_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FMV2"/>
    <dbReference type="OMA" id="QTFKKMD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.160:FF:000010">
        <property type="entry name" value="Phosphorelay intermediate protein YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HPt" evidence="10">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="9">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0134677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="161" mass="18532" checksum="F1ACCB8BF8C6F204" modified="2004-07-19" version="1">MTTVPSEIIDWTILNEIVSMDEDDPDFSKGLIIQYIDQATTTFSEMDNLLGSIDNLKELDNLGHFLKGSSAALGLQRIAWACERIQNLGRKAEDSFPERTDILKNLPDKVSVDEEDKKEEKEEVPQDDKKYLYLIKKALAQARIEFKLARRELSDYYKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN99</accession>
    <name>Q6FN99_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0K01617g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN99"/>
    <dbReference type="FunCoup" id="Q6FN99">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN99"/>
    <dbReference type="KEGG" id="cgr:2890021"/>
    <dbReference type="CGD" id="CAL0134029">
        <property type="gene designation" value="CAGL0K01617g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01617g"/>
    <dbReference type="eggNOG" id="KOG0596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019372_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN99"/>
    <dbReference type="OMA" id="YRETQIG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:peroxisome"/>
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        <property type="term" value="C:spindle pole body"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein localization to kinetochore"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:regulation of attachment of spindle microtubules to kinetochore"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14131">
        <property type="entry name" value="PKc_Mps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000131">
        <property type="entry name" value="Dual specificity protein kinase TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016242">
        <property type="entry name" value="Mps1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027084">
        <property type="entry name" value="Mps1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000611">
        <property type="entry name" value="Ser/Thr_PK_MPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="447"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="774" mass="87908" checksum="5D95038A881139E2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNC3</accession>
    <name>Q6FNC3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial 20 kDa outer membrane protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import receptor subunit tom20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translocase of outer membrane 20 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0K01067g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Tom20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNC3"/>
    <dbReference type="FunCoup" id="Q6FNC3">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNC3"/>
    <dbReference type="KEGG" id="cgr:2890155"/>
    <dbReference type="CGD" id="CAL0134943">
        <property type="gene designation" value="CAGL0K01067g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01067g"/>
    <dbReference type="eggNOG" id="KOG4056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090411_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNC3"/>
    <dbReference type="OMA" id="PPPIFQI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000002">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0134943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG61232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="184" mass="20206" checksum="07EB5F4EDE3A8EFF" modified="2004-07-19" version="1">MAQSLGRTLAAATAVGAVALSAYALYFDHQRRSNPEFRKELKRRVKKEAKAAQVAEEQAKRQKLEKVTQYLTQELAADPIPASATERETVFTKNVELGERLSMTPGQELEAAAKFYKALTVYPNPADLLGIYQRSVPENIYEYIVLMIAIMPPANVSTFIRGAAAGNDNAAAKEVEESVADVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FND9</accession>
    <name>Q6FND9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein RTA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RTA1</name>
        <name evidence="8 9" type="ordered locus">CAGL0K00715g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448255.1">
        <property type="nucleotide sequence ID" value="XM_448255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FND9"/>
    <dbReference type="FunCoup" id="Q6FND9">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FND9"/>
    <dbReference type="GeneID" id="2890515"/>
    <dbReference type="KEGG" id="cgr:2890515"/>
    <dbReference type="CGD" id="CAL0134951">
        <property type="gene designation" value="RTA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00715g"/>
    <dbReference type="eggNOG" id="ENOG502QURG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033465_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FND9"/>
    <dbReference type="OMA" id="LMKHEVF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38597" checksum="3CADDC6BD649DEA3" modified="2004-07-19" version="1">MSTNSTINLSDDFKFDFYKYTPNLGASIAFAVLFLIAAIIITGQLWILTKSHRQFLTQWMNSPTYYANIRHYNTFKLFAAHIPLIVGCIIEVVGYIARSVSRHDVYSLPPFAVQVVLLLVGPTLYAASIYMVFGRMAHLMFVENLMIMPARFNTVIFVLGDVASLLLQAAGGGMQASASTEKAGSNIVTVGLFIQIAFFGIFMINEFLFVIRVRALRNKNKIASKSNTWIYYNWILIVNSAMILVRSIVRTVEFIQGYDGYITSHEYFLYIFDATPMFLLPLITIVFMMKYNIFEIQRESIQIQSELDKDYESEDNDSSLDIEADIEDGSENRMSKTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNG0</accession>
    <name>Q6FNG0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0K00231g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNG0"/>
    <dbReference type="FunCoup" id="Q6FNG0">
        <property type="interactions" value="902"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNG0"/>
    <dbReference type="KEGG" id="cgr:2890513"/>
    <dbReference type="CGD" id="CAL0133793">
        <property type="gene designation" value="CAGL0K00231g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00231g"/>
    <dbReference type="eggNOG" id="KOG1939">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002157_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FNG0"/>
    <dbReference type="OMA" id="QMGTQLR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="543"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="742"/>
            <end position="1275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0133793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1280" mass="141512" checksum="042613F37EAC4997" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNQ4</accession>
    <name>Q6FNQ4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial outer membrane protein porin 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J09900g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNQ4"/>
    <dbReference type="FunCoup" id="Q6FNQ4">
        <property type="interactions" value="1150"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNQ4"/>
    <dbReference type="KEGG" id="cgr:2889425"/>
    <dbReference type="CGD" id="CAL0133160">
        <property type="gene designation" value="CAGL0J09900g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09900g"/>
    <dbReference type="eggNOG" id="KOG3126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044399_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FNQ4"/>
    <dbReference type="OMA" id="KPCCSHE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044289">
        <property type="term" value="C:mitochondrial inner-outer membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051027">
        <property type="term" value="P:DNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042307">
        <property type="term" value="P:positive regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0626">Porin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0133160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30351" checksum="5B57DD61D7CD6720" modified="2004-07-19" version="1">MAPPFFSDIFKSVNDLLNKDFYHSTPAAVDLESVAKNGVKFNVKSKQLVKEGPLAATVDAKFTDKATGLTLTQGWSNANNLNTKIELNNITPGLKTELMTSFVPNISKVANLNLSFVQPFFTARGAFDLLKGPGFVGDMTLAHESGVVAGAQFGYDIAAGSLSKYAIALGYAAQDYHLGLNINNDQVTTATFFQNVSPQLQIGSRATLNPRQTVSNVNIEFATKYLPDPNSQVKAKISDAGIVALSYKQALRPGVTLGVGTSFDALKLSEPVHKIGWSLSFVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-11-23" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNR4</accession>
    <name>HEM3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Porphobilinogen deaminase</fullName>
            <shortName>PBG</shortName>
            <ecNumber>2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Hydroxymethylbilane synthase</fullName>
            <shortName>HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HEM3</name>
        <name type="ordered locus">CAGL0J09680g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="1">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="pathway">
        <text>Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="miscellaneous">
        <text>The porphobilinogen subunits are added to the dipyrromethan group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448130.1">
        <property type="nucleotide sequence ID" value="XM_448130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNR4"/>
    <dbReference type="SMR" id="Q6FNR4"/>
    <dbReference type="FunCoup" id="Q6FNR4">
        <property type="interactions" value="680"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNR4"/>
    <dbReference type="EnsemblFungi" id="CAGL0J09680g-T">
        <property type="protein sequence ID" value="CAGL0J09680g-T-p1"/>
        <property type="gene ID" value="CAGL0J09680g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889718"/>
    <dbReference type="KEGG" id="cgr:2889718"/>
    <dbReference type="CGD" id="CAL0133604">
        <property type="gene designation" value="CAGL0J09680g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J09680g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09680g"/>
    <dbReference type="eggNOG" id="KOG2892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FNR4"/>
    <dbReference type="OMA" id="NAHEWAG"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.40:FF:000002">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0350">Heme biosynthesis</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000143039" description="Porphobilinogen deaminase">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="1">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="329" mass="36835" checksum="9400A8E853FFB1C7" modified="2004-07-19" version="1">MTRESINIGGRRSKLAVVQSNHVRDLVQAKFPQYDCTVFTLQTLGDQIQFKPLYSFGGKALWTKELEDYLYCEDQEKRLDLIVHSLKDMPTLLPDGFELGCVTKRVDPTDCIVMPRGSPHRCLADLPEGAVVGTSSVRRSAQLKRKFPHLKYQSVRGNIHTRLEKLDDPEGPFQCLVLASAGLVRMGLEDRITQRLHSDIMYHAVGQGALGIEIRQGDKKILQILDEIADLESTVCCLAERSLMRTLEGGCSVPIGVESSYDHKTKKLLLKGIVVNVEGTMAIEDQQEVVVNDIREDSIKCGVLLAHKMIKDGAKKILDEINLERVIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNY6</accession>
    <name>Q6FNY6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein YIF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0J08052g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the YIF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNY6"/>
    <dbReference type="FunCoup" id="Q6FNY6">
        <property type="interactions" value="556"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNY6"/>
    <dbReference type="KEGG" id="cgr:2889915"/>
    <dbReference type="CGD" id="CAL0133536">
        <property type="gene designation" value="CAGL0J08052g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08052g"/>
    <dbReference type="eggNOG" id="KOG3094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047877_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FNY6"/>
    <dbReference type="OMA" id="SGYKFVH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0133536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="309" mass="35182" checksum="A4E64D85A0837651" modified="2004-07-19" version="1">MSYNPYSFQGEATANDRFRHGSQPSMEQGQPLFGAQQASQQQMPPQQQQQQQQPGFNFQNPTQSMAFQLGQSAFSNFIGEQNFSQFQETVSKATSANGSLSLYFQVTTNYVINKLRVILIPFTNKNWQRIPEAQQGSNGALSFMPPKDDINSPDMYIPIMGLVTYILIWNTQQGLKGSFNPENLYYKLSSTVAFVLLDLVILKLGLYLLVSTNSRTTNIVELICFVGYKFVPLILALFLPSSPIYLKMIVQVYLFIAFGVFLLRSVKFNLFTNTNSDMVTFNKATVRKCNYFLFVYGFIWQSILMWLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP57</accession>
    <name>Q6FP57_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J06468g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP57"/>
    <dbReference type="STRING" id="284593.Q6FP57"/>
    <dbReference type="CAZy" id="GT20">
        <property type="family name" value="Glycosyltransferase Family 20"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889539"/>
    <dbReference type="CGD" id="CAL0133442">
        <property type="gene designation" value="CAGL0J06468g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06468g"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002351_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FP57"/>
    <dbReference type="OMA" id="CHEFIVC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000099">
        <property type="entry name" value="Alpha,alpha-trehalose phosphate synthase subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0133442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1065" mass="119060" checksum="4AC8214675807B05" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPG0</accession>
    <name>Q6FPG0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial 2-oxodicarboxylate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAGL0J04114g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPG0"/>
    <dbReference type="FunCoup" id="Q6FPG0">
        <property type="interactions" value="233"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889646"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04114g"/>
    <dbReference type="eggNOG" id="KOG0754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_5_2_1"/>
    <dbReference type="InParanoid" id="Q6FPG0"/>
    <dbReference type="OMA" id="LPFQYQF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="200"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33453" checksum="86F9371547E2ED75" modified="2004-07-19" version="1">MSEKPLPFIYQFVSGAAAGVSELLVMYPLDVVKTRMQLQVGSGTGSGVAYNGVIDCLGQIVKREGFSRLYKGISSPMLMEAPKRATKFACNDSYQKMFKDLYGVDKLTQQISILSGSLAGVTEACVIVPFELVKIRLQDVNSKFNGPMEVVFKTIRETGILSLYNGLESTMWRNAFWNGGYFGVIFQIRALLPKAKTNTEKTTNDLIAGTIGGYCRYSTEHTILSVVKSRIQSGATTTLADGTVVPKYNWTWPSLFKIYSEEGFTALYKGFIPKILRLGPGGGIMLVVFNGMMAFFQEMKYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPI7</accession>
    <name>Q6FPI7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PPIase cyclophilin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0J03520g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPI7"/>
    <dbReference type="FunCoup" id="Q6FPI7">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPI7"/>
    <dbReference type="KEGG" id="cgr:2889698"/>
    <dbReference type="CGD" id="CAL0133008">
        <property type="gene designation" value="CAGL0J03520g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03520g"/>
    <dbReference type="eggNOG" id="KOG0880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FPI7"/>
    <dbReference type="OMA" id="LYEPNPP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF568">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE CPR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274761" description="PPIase cyclophilin-type domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="4">
        <location>
            <begin position="48"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0133008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="322" mass="36542" checksum="4B1CB80162C25D72" modified="2004-07-19" version="1">MLANILLFLFTMLFSMQSTLADSADVDLRSMYAPDPPATNRISMTISYFPKGSDVKKEVDFSIDVYGTVCPKARDNFITLIRGIKAVIEGRGSGVMTLRYPGTKFTNVLPNKYILGGEILPGISPYSIYGDKWPEENFDLKFDRPGRIAMWNHGQGKQESQFFISTNPKPDTELDGRYSIFGQVVSGLDVILNEVQHAEVSSTKDMILKYMVKEDLRLAKPDELHAKWLKRLEEYNNGDKTKGVSIARYFKAEETAAIPKKMPANALYNGYVRHSGFPLFKVFFILVSLAVCFYVFKHRAEFLKRTNIVSLKQWRSVPETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPK0</accession>
    <name>Q6FPK0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aldehyde dehydrogenase 5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALD5</name>
        <name evidence="11 12" type="ordered locus">CAGL0J03212g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Minor mitochondrial aldehyde dehydrogenase isoform. Plays a role in regulation or biosynthesis of electron transport chain components. Involved in the biosynthesis of acetate during anaerobic growth on glucose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447844.1">
        <property type="nucleotide sequence ID" value="XM_447844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPK0"/>
    <dbReference type="SMR" id="Q6FPK0"/>
    <dbReference type="FunCoup" id="Q6FPK0">
        <property type="interactions" value="648"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPK0"/>
    <dbReference type="GeneID" id="2889731"/>
    <dbReference type="KEGG" id="cgr:2889731"/>
    <dbReference type="CGD" id="CAL0132778">
        <property type="gene designation" value="ALD5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03212g"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FPK0"/>
    <dbReference type="OMA" id="WSNTFNK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019413">
        <property type="term" value="P:acetate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="49"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0132778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="517" mass="56166" checksum="D5DC80E441FC61CE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPQ2</accession>
    <name>Q6FPQ2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Mitochondrial nicotinamide adenine dinucleotide transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0J02002g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Mitochondrial inner membrane carrier protein that mediates the import of NAD(+) into mitochondria. Can transport NAD(+) by unidirectional transport or by exchange with intramitochondrially generated dAMP and dGMP. Also able to transport NAD(+) by exchange with AMP, GMP or deamido-NAD (+) in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>AMP(in) + NAD(+)(out) = AMP(out) + NAD(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:65424"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:65425"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GMP(in) + NAD(+)(out) = GMP(out) + NAD(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:65420"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:65421"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>dAMP(in) + NAD(+)(out) = dAMP(out) + NAD(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:65412"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58245"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:65413"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dGMP(in) + NAD(+)(out) = dGMP(out) + NAD(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:65416"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57673"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:65417"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>deamido-NAD(+)(in) + NAD(+)(out) = deamido-NAD(+)(out) + NAD(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:65428"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:65429"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPQ2"/>
    <dbReference type="FunCoup" id="Q6FPQ2">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889783"/>
    <dbReference type="CGD" id="CAL0132888">
        <property type="gene designation" value="CAGL0J02002g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02002g"/>
    <dbReference type="eggNOG" id="KOG0764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_1_1"/>
    <dbReference type="InParanoid" id="Q6FPQ2"/>
    <dbReference type="OMA" id="AFYNGMG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990549">
        <property type="term" value="P:mitochondrial NAD transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000081">
        <property type="entry name" value="NAD+ transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000106">
        <property type="entry name" value="NAD+ transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="66"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="166"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="16">
        <location>
            <begin position="270"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0132888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG60741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="40669" checksum="43EB6E7D71B0399F" modified="2004-07-19" version="1">MGQDEFYREKSHPEEICFPDSASPLTSTDVIEPFRGDTIDNKMEAYKGLVQEVPRVRNTLFGFTLNDNRINAISGALAGLLSGIVVCPLDVAKTRLQAQGLQTRTTENLYYRGSIGTMTTIVRDEGVRGLYKGLVPIIMGYFPTWMIYFSVYEFCKDNLRTNSSNWSFVSHSFSAITAGAVSTVVTNPIWVVKTRLMLQTHIGSNTTHYQGTYDAFKKIINQEGVKALYAGLVPSLLGLLHVAIHFPVYERLKVSFKCYQRDESSNESKINLKRLILASSVSKMVASVLSYPHEILRTRLQLKSDLPSHQRRLIPLIKITYIQEGIFGFYSGFGTNLFRTLPASAITLVSFEYVRNFLNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPQ9</accession>
    <name>Q6FPQ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20 21" type="ordered locus">CAGL0J01848g</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPQ9"/>
    <dbReference type="FunCoup" id="Q6FPQ9">
        <property type="interactions" value="1062"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPQ9"/>
    <dbReference type="KEGG" id="cgr:2889810"/>
    <dbReference type="CGD" id="CAL0132808">
        <property type="gene designation" value="CAGL0J01848g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01848g"/>
    <dbReference type="eggNOG" id="KOG0216">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FPQ9"/>
    <dbReference type="OMA" id="FFGVVHY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="41"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="207"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="483"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="19">
        <location>
            <begin position="590"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="698"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="1064"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0132808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG60734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1202" mass="135440" checksum="B741C34622203A66" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-10-25" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ15</accession>
    <name>GNT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Glucose N-acetyltransferase 1</fullName>
            <ecNumber>2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>N-acetylglucosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GNT1</name>
        <name type="ordered locus">CAGL0I09922g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text>N-acetylglucosaminyltransferase involved in the Golgi-specific modification of N-linked glycans.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GNT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447679.1">
        <property type="nucleotide sequence ID" value="XM_447679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ15"/>
    <dbReference type="FunCoup" id="Q6FQ15">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ15"/>
    <dbReference type="CAZy" id="GT8">
        <property type="family name" value="Glycosyltransferase Family 8"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q6FQ15">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0I09922g-T">
        <property type="protein sequence ID" value="CAGL0I09922g-T-p1"/>
        <property type="gene ID" value="CAGL0I09922g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889277"/>
    <dbReference type="KEGG" id="cgr:2889277"/>
    <dbReference type="CGD" id="CAL0130352">
        <property type="gene designation" value="CAGL0I09922g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09922g"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034860_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ15"/>
    <dbReference type="OMA" id="ILPHRVY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000087533" description="Glucose N-acetyltransferase 1">
        <location>
            <begin position="1"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Signal-anchor for type II membrane protein" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DXD">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="501" mass="58333" checksum="2D304213BCF509E6" modified="2004-07-19" version="1">MRLVSRRRLKGLALVAFALIGITIFVRILMEFQLEREVSFYKKFFRLKKDGLHGVYNPIDIKQIPKQTIDDLYRAKMETVSASKPIDWSKYAYVNYVTEPNYLCNTLIMFHALIKKFGTKAKLELLISNELFKSEIQSRNEQVQRILKKIRELDSEQIVIKEVQNIVKPTDQSPWNESLTKLLVFGLTEYERIIYLDNDAILQDKMDELFFLPNDITFAAPLTYWFMSEKDLEKTYKEVQHDKMSINLNKYTKQLSNRIRNGKEIYNHLPALPQSLYLNSDRVAKEILDSTSSASPLFDADSLKKVGKVKFASNLMVIKPSQETYDYIINDCLPRIVNKKEKYDMDLINEELYNLRHVVSRQVTLFRKLRSAFKPSILVLPFGTYGILTGSIRKPQEHMIMRNDILGYKNIDDEGNEIQKSIEEVVLNNKYIHFSDFPLGKPWAYSSFDQLKCRVDPASSKDVAADQKNCDVWNSIYESYFTQRMVCSKDDSPKASEIQAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ75</accession>
    <name>MED10_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NUT2</name>
        <name type="synonym">MED10</name>
        <name type="ordered locus">CAGL0I08525g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447619.1">
        <property type="nucleotide sequence ID" value="XM_447619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ75"/>
    <dbReference type="SMR" id="Q6FQ75"/>
    <dbReference type="FunCoup" id="Q6FQ75">
        <property type="interactions" value="630"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ75"/>
    <dbReference type="EnsemblFungi" id="CAGL0I08525g-T">
        <property type="protein sequence ID" value="CAGL0I08525g-T-p1"/>
        <property type="gene ID" value="CAGL0I08525g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888923"/>
    <dbReference type="KEGG" id="cgr:2888923"/>
    <dbReference type="CGD" id="CAL0132398">
        <property type="gene designation" value="CAGL0I08525g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08525g"/>
    <dbReference type="eggNOG" id="KOG3046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096169_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ75"/>
    <dbReference type="OMA" id="QYQRAKM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF13">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000303167" description="Mediator of RNA polymerase II transcription subunit 10">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="199" mass="22051" checksum="7C444C5FFF1511EF" modified="2004-07-19" version="1">MGSVKSSNPALEGLHEELGVMEEQIRSIIESFIELGVSVYDFPGTPEASQGMVTNLKRNVDRIFKLNQTSNDPQSALKDVNVPLEVVQYIEDGRNPDIYTREFVEAIRRSNQYQRAKMHGMGMLRDSLAEKIKEQFPELKDDVENIVQRTNMKPTGQARVNSGTTNMTTTAEQSNVVNATAGDVGTNANTTESVEQNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ76</accession>
    <name>Q6FQ76_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoadenylyl-sulfate reductase (thioredoxin)</fullName>
            <ecNumber evidence="3">1.8.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">PAdoPS reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0I08503g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="3"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ76"/>
    <dbReference type="FunCoup" id="Q6FQ76">
        <property type="interactions" value="702"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ76"/>
    <dbReference type="KEGG" id="cgr:2888922"/>
    <dbReference type="CGD" id="CAL0132658">
        <property type="gene designation" value="CAGL0I08503g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08503g"/>
    <dbReference type="eggNOG" id="KOG0189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044089_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FQ76"/>
    <dbReference type="OMA" id="PIARWTQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="13">
        <location>
            <begin position="43"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0132658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="259" mass="29585" checksum="4DD1B7FD23BEB7FE" modified="2004-07-19" version="1">MKVYNLNNGISVTEEQLAHWNQALSQLEPQEILKWSLATFPHLFQTTAFGLTGLATIDMLSKLGADALVPLITIDTLHLFPQTVTLRENVEDKYYRPHGKTIHVYKPIGCDTEQQFADKYGEFLWETDDDKYDYLVKVEPAARAYKDLQVTAVFTGRRKSQGSARSELQFVEIEELTGIIKINPLANWTFDQVKQYIDDNAVPYNELLDLGYKSIGDYHSTVPVKEGEDERSGRWKGKAKTECGIHETSRFAKFLKQDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ96</accession>
    <name>Q6FQ96_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ROA1</name>
        <name evidence="10 11" type="ordered locus">CAGL0I08019g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
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                <person name="Jauniaux N."/>
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                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
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                <person name="Zivanovic I."/>
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                <person name="Thierry A."/>
                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_000604_57_4_1"/>
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        <property type="entry name" value="ABC2_TM"/>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="473"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="511"/>
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    </feature>
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        <location>
            <begin position="591"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1029"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1104"/>
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        <location>
            <begin position="1139"/>
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        <location>
            <begin position="1169"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1257"/>
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        <location>
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    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <sequence length="1285" mass="144443" checksum="42E32A146225842C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQK2</accession>
    <name>Q6FQK2_CANGA</name>
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        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0I05588g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG60429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQK2"/>
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        <property type="gene designation" value="CAGL0I05588g"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
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        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102264">
        <property type="term" value="F:tRNA-dihydrouridine20 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="DUS_fam"/>
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    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 10 12" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="14">
        <location>
            <begin position="10"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="338"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0130322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG60429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="371" mass="41728" checksum="3B5DD0232A532D6C" modified="2004-07-19" version="1">MDMYAGKLVLAPMVRAGELPTRLMALKYGAGLVWSPEIIDKKLIQTQRVENSSLSSVDYVMPSGVLVFRTVPSLERGKLIFQIGSADPALAKEAALKVIQDVDGIDLNCGCPKHFSIHAGMGSALLKKPEKLCSILKELVEHVGTPHGKPISCKIRLLEDEASTLELVKMICDTGIRNLTVHCRTTPMRNRETPIRDYIDSIFSVCKKAGVSLLINGAIRHREEFEQLFSYNPEIGGMIAEAAESNPTVFSKDVLPWHQTVKEFLEIAKKYENNIGNTKYMLSRLVPGKSKFFQYYAQCKTVEDLDHISSLIDDNGEPKGDPSEYLIKRREEEKLLKRQEGERKALERKLAKQQKRELEVESDSNKKPKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQQ5</accession>
    <name>Q6FQQ5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0I04378g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447439.1">
        <property type="nucleotide sequence ID" value="XM_447439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQQ5"/>
    <dbReference type="STRING" id="284593.Q6FQQ5"/>
    <dbReference type="CAZy" id="GT15">
        <property type="family name" value="Glycosyltransferase Family 15"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889048"/>
    <dbReference type="CGD" id="CAL0132180">
        <property type="gene designation" value="CAGL0I04378g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04378g"/>
    <dbReference type="eggNOG" id="KOG4472">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024327_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FQQ5"/>
    <dbReference type="OMA" id="DWYFRVE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF10">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0132180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="424" mass="50115" checksum="7A49D9F986FA83B4" modified="2004-07-19" version="1">MHAHQVNIKAVILLTTLTVLVWLPSFREWNRILSLRSKDQHYLDKSALIRSKYLQKTRDTIYKPLKMSSHTAADNNNLITTSMDINNFEKQNATFVMLARNSDVNDAVEAIKSLESRFNHKYHYDWAFFNDVPFDEDFIRRTTEVASGKTQYGLIPKDNWDIPSWINKTTMNNNMNIFNEENMLYGSSISYRNMCRYNSGFFFRQKLLDGYDYYMRVDPDVHFLCDLPYDPFEMMVVNHKKYGFVITMHEIGSTIPTLWDTVKKFISQHSDLINKNNLLGFLTDKNDLGKNKFKAHFQDDYNLCHFWTNLEVGDLNFFRSDKYLKFFDFLDANGGFYYERWGDAPIHSIAAALFLDKDEIIHFEEIGYHHMPYYHCPMPNAFWDSHKCACSRSGQFNVINNEINCLPRYWKHNGKTFVKEPGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQU8</accession>
    <name>Q6FQU8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0I03410g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQU8"/>
    <dbReference type="FunCoup" id="Q6FQU8">
        <property type="interactions" value="734"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQU8"/>
    <dbReference type="KEGG" id="cgr:2889175"/>
    <dbReference type="CGD" id="CAL0132698">
        <property type="gene designation" value="CAGL0I03410g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03410g"/>
    <dbReference type="eggNOG" id="KOG0967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FQU8"/>
    <dbReference type="OMA" id="WIKYKRD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-dep_DNA_ligase"/>
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        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="468"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0132698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG60333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="724" mass="81834" checksum="478F553CDA7840EA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRG8</accession>
    <name>Q6FRG8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0H08690g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRG8"/>
    <dbReference type="FunCoup" id="Q6FRG8">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRG8"/>
    <dbReference type="KEGG" id="cgr:2888720"/>
    <dbReference type="CGD" id="CAL0129748">
        <property type="gene designation" value="CAGL0H08690g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08690g"/>
    <dbReference type="eggNOG" id="KOG1861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015513_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FRG8"/>
    <dbReference type="OMA" id="RETMNFK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="251"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="440" mass="50856" checksum="634265665D8AF1F4" modified="2004-07-19" version="1">MSYNQVTPIALGQRSKRKIVPKAEPKDDKKIEVQANKGKNVLKKPPVANTNSVVNPAVSVFPQPNKVRPSRIAQKGPTKQNNTNGSNRTNKKLKSNEGKVRHPNNNRTNSSGGLSETERRRKRAERFSKANNTISKNELEHEDNFSDLNSIGTKSHIFNKDQRIVGRCQKLEKSYLRLTSEPNPEMIRPPEVLEKALEMLMEKYKNKEVNYTYLCDQFKSIRQDLRVQMIEDSFTMTVYQEHARIALENDDLGEFNQCQSRLMVLYDNTTIKRTHREEFTVYLILYYVLMQDYSAIDALKLELIRERGRSIKNAGIALAFEIAETRLVGNYHKFMKLCASLKGLGQKLIKAFMDQEILKTLVTICRSYNQVNLVFLTKELEFETADETIQYLKRKNLGNYIVTKNLNMPNEFKYLDTKACRIEVIQAYAKLKKVDIKGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRL9</accession>
    <name>Q6FRL9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cell division control protein 28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0H07535g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRL9"/>
    <dbReference type="SMR" id="Q6FRL9"/>
    <dbReference type="FunCoup" id="Q6FRL9">
        <property type="interactions" value="1184"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRL9"/>
    <dbReference type="KEGG" id="cgr:2888771"/>
    <dbReference type="CGD" id="CAL0131580">
        <property type="gene designation" value="CAGL0H07535g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07535g"/>
    <dbReference type="eggNOG" id="KOG0594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q6FRL9"/>
    <dbReference type="OMA" id="YLYQITR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001033">
        <property type="term" value="P:negative regulation of double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051447">
        <property type="term" value="P:negative regulation of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903500">
        <property type="term" value="P:negative regulation of mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045930">
        <property type="term" value="P:negative regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045875">
        <property type="term" value="P:negative regulation of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905168">
        <property type="term" value="P:positive regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045819">
        <property type="term" value="P:positive regulation of glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051446">
        <property type="term" value="P:positive regulation of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045931">
        <property type="term" value="P:positive regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904291">
        <property type="term" value="P:positive regulation of mitotic DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010696">
        <property type="term" value="P:positive regulation of mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901319">
        <property type="term" value="P:positive regulation of trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010898">
        <property type="term" value="P:positive regulation of triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990139">
        <property type="term" value="P:protein localization to nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902889">
        <property type="term" value="P:protein localization to spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010568">
        <property type="term" value="P:regulation of budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010570">
        <property type="term" value="P:regulation of filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905634">
        <property type="term" value="P:regulation of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090169">
        <property type="term" value="P:regulation of spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000144">
        <property type="entry name" value="Cyclin-dependent kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="8"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0131580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG60058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="298" mass="34086" checksum="6C0C58197DEEBF27" modified="2004-07-19" version="1">MSSELANYKRLEKVGEGTYGVVYKALDLRPGKGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKLYLVLEFLDLDLKRYMESIPKDQPLGVNIIKKFMVQLCKGIAYCHAHRILHRDLKPQNLLIDKEGNLKLGDFGLARAFGVPLRAYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCNRKPIFSGDSEIDQIFKIFRILGTPSEAVWPDIVYLPDFKPSFPQWRRKDLAEVVPSLDPHGIDLLDKLLAYDPINRISARRAANHPYFHEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRS0</accession>
    <name>Q6FRS0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SSR1</name>
        <name evidence="9 10" type="ordered locus">CAGL0H06413g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRS0"/>
    <dbReference type="STRING" id="284593.Q6FRS0"/>
    <dbReference type="KEGG" id="cgr:2888857"/>
    <dbReference type="CGD" id="CAL0131444">
        <property type="gene designation" value="SSR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06413g"/>
    <dbReference type="eggNOG" id="ENOG502S1X2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078308_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRS0"/>
    <dbReference type="OMA" id="ICPNDNA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044650">
        <property type="term" value="P:adhesion of symbiont to host cell"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274162" description="CFEM domain-containing protein" evidence="7">
        <location>
            <begin position="20"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="8">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="124"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0131444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="212" mass="20683" checksum="F3AA15BBB2320C99" modified="2004-07-19" version="1">MRAAVVSAVVLGLFSQVLATPPACLLACVAQVSKQSSQCHTLNQVGCFCENENTAIKNCLDSICPNGNSDAAYTAFKNSCGDVGKAVASVSSSMSSSMSSSASSSMSSSMSSSSSSSSSASSSISSVSSSTSSVVTTGSSSAPKVSESTTSTPSSTASSTFTITSSKPSSVSSTKTSQKPSSSHAISTFSAGANAINAGSGLAVIAAAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSH3</accession>
    <name>Q6FSH3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Histone demethylase JHD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0H00528g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSH3"/>
    <dbReference type="FunCoup" id="Q6FSH3">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSH3"/>
    <dbReference type="KEGG" id="cgr:2888565"/>
    <dbReference type="CGD" id="CAL0131984">
        <property type="gene designation" value="CAGL0H00528g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00528g"/>
    <dbReference type="eggNOG" id="KOG1246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000991_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FSH3"/>
    <dbReference type="OMA" id="TFPKCYH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071041">
        <property type="term" value="P:antisense RNA transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060623">
        <property type="term" value="P:regulation of chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="11">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="ARID" evidence="10">
        <location>
            <begin position="73"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="256"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="12">
        <location>
            <begin position="383"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="199"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0131984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="86240" checksum="926A371C883B4F3A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSM0</accession>
    <name>Q6FSM0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G09537g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="cgr:2888390"/>
    <dbReference type="CGD" id="CAL0130472">
        <property type="gene designation" value="CAGL0G09537g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09537g"/>
    <dbReference type="HOGENOM" id="CLU_2512403_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSM0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="85" mass="9699" checksum="CE5E1C09CCDFCDEC" modified="2004-07-19" version="1">MSNESTIEPDTPPADDRMKSRDTADKDGGETHNGKKDYGKVKHWVEVEQGIPVKSFTSYTLNLSGWVREDQKKEVKDERKDTSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSN9</accession>
    <name>Q6FSN9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein YIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0G09064g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSN9"/>
    <dbReference type="FunCoup" id="Q6FSN9">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSN9"/>
    <dbReference type="KEGG" id="cgr:2888040"/>
    <dbReference type="CGD" id="CAL0130049">
        <property type="gene designation" value="CAGL0G09064g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09064g"/>
    <dbReference type="eggNOG" id="ENOG502S8CN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_588135_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSN9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0130049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="56578" checksum="E2942CBD14BF657F" modified="2004-07-19" version="1">MGLPITLYQEDMNSLHLPQKRNLDQFIRERFPSVAYPTASELRSLRRGNTSVRPLTQVIRQEVYAYFMNNNVNERIFASIEDNTANHRRQNMYDWDSAGIDRWTIDIDPETVEINDVPNLNGYRCNQNYDNSLWMYFNESNNFEQFYLYDTKENRYVKGCLERSLVEHNDTLCCVDAKSGMNNYQFLLGFTSGKVVLVTSTLLGDDGLNAWCESEVVYQSRTSSHPIRNNSRYNGIVTVNASLLPSYVLSFNIKEGLILSELTDHSNYKIDIPYNNQDFSDVDSSQFSAVVNFPQFVLSNGVQIWNYENVLQINASLFPVDHEVKFWLKPEEKIKYIKPMPKQEHLFVVTTERGVSIPINPANNHVPRGRAVRSSNADPSYSEVTNVIPVFTLADYNENQYQLETFNSEQYLMTTQQHLYGTSLTIYQYSNASKDWFSLGFVDIRAKFNIRKIKALSILESHDDQNPNQKPKLLIHANDGTIRHFKICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSX1</accession>
    <name>Q6FSX1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAGL0G07188g</name>
        <name evidence="3" type="ORF">CAGL0G07183g1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446673.1">
        <property type="nucleotide sequence ID" value="XM_446673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSX1"/>
    <dbReference type="KEGG" id="cgr:90657431"/>
    <dbReference type="CGD" id="CAL0000203871">
        <property type="gene designation" value="CAGL0G07188g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07188g"/>
    <dbReference type="HOGENOM" id="CLU_1015627_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSX1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0000203871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="274" mass="32313" checksum="8180ADC661F96A3D" modified="2004-07-19" version="1">MVAPASNRNTRPAEEPERTSRPAEEPERTTRPSETPDSDYDSSLDLYPPDSDLLEEESKLRHYLKDEVEHLTKKIARSNARRKEWLTDMRGAVRKFRTLPDKVLINNIRRATDDDIKYDLTKIREDLPSRITIKTFLKAIDNHYERSSKETVRHVNLIDRPKFITAASLRRARDAFENICDEENMTCAIYATKHYLPPRIERQIDDLHWPSPSTILDELDNEIEKRKAKEKYFKSNKYKNKFNKRRYNPKRFNNNRRNNNSSGGGFSSNKNTKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT12</accession>
    <name>LTE1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Guanine nucleotide exchange factor LTE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LTE1</name>
        <name type="ordered locus">CAGL0G06226g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GDP-GTP exchange factor component of the mitotic exit network (MEN). Fine-tunes the timing of the mitotic exit and couples this event with cytokinesis. May also be involved in proprotein-processing in the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Bud</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the LTE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446632.1">
        <property type="nucleotide sequence ID" value="XM_446632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT12"/>
    <dbReference type="SMR" id="Q6FT12"/>
    <dbReference type="FunCoup" id="Q6FT12">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT12"/>
    <dbReference type="EnsemblFungi" id="CAGL0G06226g-T">
        <property type="protein sequence ID" value="CAGL0G06226g-T-p1"/>
        <property type="gene ID" value="CAGL0G06226g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888077"/>
    <dbReference type="KEGG" id="cgr:2888077"/>
    <dbReference type="CGD" id="CAL0129973">
        <property type="gene designation" value="CAGL0G06226g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06226g"/>
    <dbReference type="eggNOG" id="KOG3417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004883_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT12"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031536">
        <property type="term" value="P:positive regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902480">
        <property type="term" value="P:protein localization to mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000019">
        <property type="entry name" value="Guanine nucleotide exchange factor LTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019804">
        <property type="entry name" value="Ras_G-nucl-exch_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00720">
        <property type="entry name" value="RASGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000285405" description="Guanine nucleotide exchange factor LTE1">
        <location>
            <begin position="1"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="2">
        <location>
            <begin position="29"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="3">
        <location>
            <begin position="1073"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="694"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="842"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="844"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="1318" mass="150362" checksum="A919771CEC287D67" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTA1</accession>
    <name>Q6FTA1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="3 13">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0G04147g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cleaves A-5'-PPP-5'A to yield AMP and ADP. Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine. Is most effective on dinucleoside triphosphates. Negatively regulates intracellular dinucleoside polyphosphate levels, which elevate following heat shock.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="3 13"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTA1"/>
    <dbReference type="FunCoup" id="Q6FTA1">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTA1"/>
    <dbReference type="KEGG" id="cgr:2888120"/>
    <dbReference type="CGD" id="CAL0130675">
        <property type="gene designation" value="CAGL0G04147g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04147g"/>
    <dbReference type="eggNOG" id="KOG3379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_7_2_1"/>
    <dbReference type="InParanoid" id="Q6FTA1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015964">
        <property type="term" value="P:diadenosine triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="14">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="12">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="11">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0130675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG59470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="190" mass="22315" checksum="0B94BE9176062176" modified="2004-07-19" version="1">MSGSTPIYFSKFLVTEQVFFRTRFSYALVNLKPITKGHVLVVPLRSQVVQLSQLTPQENADYFNTVQLIHQFMKWVYKAQAVNIAIQDGPEAGQSVPHLHTHIIPRYKENNIGDKVYERLDDWDLRRDEYMKARDMNEEGTNLRPDQDDVRIARSMEEMKKEVDFLKAQLEEFLSNHCDVKKWLPTDARQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTE0</accession>
    <name>YKR18_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>IML2-like protein CAGL0G03245g</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAGL0G03245g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in mitochondrial DNA stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IML2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446504.1">
        <property type="nucleotide sequence ID" value="XM_446504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTE0"/>
    <dbReference type="FunCoup" id="Q6FTE0">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0G03245g-T">
        <property type="protein sequence ID" value="CAGL0G03245g-T-p1"/>
        <property type="gene ID" value="CAGL0G03245g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888070"/>
    <dbReference type="CGD" id="CAL0137759">
        <property type="gene designation" value="CAGL0G03245g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03245g"/>
    <dbReference type="eggNOG" id="KOG3783">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014926_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTE0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000333360" description="IML2-like protein CAGL0G03245g">
        <location>
            <begin position="1"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P36114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="751" mass="85129" checksum="F50E6033C22C934A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTE9</accession>
    <name>Q6FTE9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0G03047g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTE9"/>
    <dbReference type="STRING" id="284593.Q6FTE9"/>
    <dbReference type="KEGG" id="cgr:2888351"/>
    <dbReference type="CGD" id="CAL0130705">
        <property type="gene designation" value="CAGL0G03047g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03047g"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_4_1"/>
    <dbReference type="InParanoid" id="Q6FTE9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034973">
        <property type="term" value="C:Sid2-Mob1 complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:regulation of cytokinesis"/>
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        <property type="entry name" value="MobB_Sid2p-like"/>
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        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
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        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="AGC_KINASE_CTER"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="144"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="445"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0130705"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG59422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="539" mass="62709" checksum="7B2A606EA82FB978" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTG2</accession>
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        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3 4" type="ordered locus">CAGL0G02739g</name>
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    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene designation" value="CAGL0G02739g"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02739g"/>
    <dbReference type="eggNOG" id="ENOG502S1IW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451446_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTG2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR XBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="274"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="693" mass="80126" checksum="3F174BD73CC9B69B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTP5</accession>
    <name>Q6FTP5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0G00858g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTP5"/>
    <dbReference type="FunCoup" id="Q6FTP5">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTP5"/>
    <dbReference type="KEGG" id="cgr:2888169"/>
    <dbReference type="CGD" id="CAL0130239">
        <property type="gene designation" value="CAGL0G00858g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00858g"/>
    <dbReference type="eggNOG" id="ENOG502S35T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056209_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTP5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007567">
        <property type="entry name" value="Mid2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04478">
        <property type="entry name" value="Mid2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Mid2" evidence="3">
        <location>
            <begin position="167"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0130239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="353" mass="36961" checksum="4DF0298F90A5842A" modified="2004-07-19" version="1">MKLLLVLMAVATAQIVPNTIPTNTNTNTNAINTNAINTNINNNGSYSISSSISSVSSVQSISSFSSFSSLSSSSSSSIASVPTLSVLPTSSNSSTISSTSLSSSSSSSASSSLSSSSSSISSSSSSSSSSTTSSTSSSSSSSSSSSSSSSSSSSSSSTITTPTTTENPTITSIIEGKTILSDLYTTITYTPTATHGANNKKVHHGLSKKNRNIVIGCVVGIGVPLIVLTLFLLYVFCIRSPKTDFINSDGKVITAYRPNKITKWWNALMGREITEEYQSKSPLGGEASDFEDSELAYADDDDESLSYGASNMDSRQPNRNNSGASHPTRSNNLIMEEDRFYDEHGNELTTTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTS5</accession>
    <name>Q6FTS5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TOG1</name>
        <name evidence="10 11" type="ordered locus">CAGL0F09229g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446369.1">
        <property type="nucleotide sequence ID" value="XM_446369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTS5"/>
    <dbReference type="FunCoup" id="Q6FTS5">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTS5"/>
    <dbReference type="KEGG" id="cgr:2887909"/>
    <dbReference type="CGD" id="CAL0130984">
        <property type="gene designation" value="TOG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F09229g"/>
    <dbReference type="eggNOG" id="ENOG502RYRF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023197_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTS5"/>
    <dbReference type="OMA" id="GLNRWEY"/>
    <dbReference type="PHI-base" id="PHI:10883"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900409">
        <property type="term" value="P:positive regulation of cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="815"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0130984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="835" mass="96239" checksum="0DFAE7BCD6D962EC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTV1</accession>
    <name>SWC4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>SWR1-complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SWC4</name>
        <name type="ordered locus">CAGL0F08613g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SWC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446343.1">
        <property type="nucleotide sequence ID" value="XM_446343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTV1"/>
    <dbReference type="SMR" id="Q6FTV1"/>
    <dbReference type="FunCoup" id="Q6FTV1">
        <property type="interactions" value="1067"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTV1"/>
    <dbReference type="EnsemblFungi" id="CAGL0F08613g-T">
        <property type="protein sequence ID" value="CAGL0F08613g-T-p1"/>
        <property type="gene ID" value="CAGL0F08613g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887793"/>
    <dbReference type="KEGG" id="cgr:2887793"/>
    <dbReference type="CGD" id="CAL0131238">
        <property type="gene designation" value="CAGL0F08613g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08613g"/>
    <dbReference type="eggNOG" id="KOG2656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018539_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FTV1"/>
    <dbReference type="OMA" id="GNTTMYQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000076338" description="SWR1-complex protein 4">
        <location>
            <begin position="1"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="SANT">
        <location>
            <begin position="181"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="363"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="532" mass="60570" checksum="D4D6CC61FD1E3215" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTZ0</accession>
    <name>Q6FTZ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA mismatch repair protein S5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0F07733g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTZ0"/>
    <dbReference type="SMR" id="Q6FTZ0"/>
    <dbReference type="FunCoup" id="Q6FTZ0">
        <property type="interactions" value="803"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTZ0"/>
    <dbReference type="KEGG" id="cgr:2887615"/>
    <dbReference type="CGD" id="CAL0130958">
        <property type="gene designation" value="CAGL0F07733g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07733g"/>
    <dbReference type="eggNOG" id="KOG1979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FTZ0"/>
    <dbReference type="OMA" id="ANYHVKK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032390">
        <property type="term" value="C:MutLbeta complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097587">
        <property type="term" value="C:MutLgamma complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000713">
        <property type="term" value="P:meiotic heteroduplex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03483">
        <property type="entry name" value="MutL_Trans_MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000079">
        <property type="entry name" value="DNA mismatch repair protein MLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000014">
        <property type="entry name" value="DNA mismatch repair protein Mlh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="8">
        <location>
            <begin position="212"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="555"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="664"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0130958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="723" mass="81273" checksum="C9CB3514024A08BE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU42</accession>
    <name>PALI_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>pH-response regulator protein palI/RIM9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RIM9</name>
        <name type="ordered locus">CAGL0F06545g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the palI/RIM9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446252.1">
        <property type="nucleotide sequence ID" value="XM_446252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU42"/>
    <dbReference type="FunCoup" id="Q6FU42">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU42"/>
    <dbReference type="EnsemblFungi" id="CAGL0F06545g-T">
        <property type="protein sequence ID" value="CAGL0F06545g-T-p1"/>
        <property type="gene ID" value="CAGL0F06545g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887915"/>
    <dbReference type="KEGG" id="cgr:2887915"/>
    <dbReference type="CGD" id="CAL0130890">
        <property type="gene designation" value="CAGL0F06545g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_F06545g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06545g"/>
    <dbReference type="eggNOG" id="ENOG502S1J0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084537_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FU42"/>
    <dbReference type="OMA" id="DWPGWLM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000058210" description="pH-response regulator protein palI/RIM9">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="30"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="151"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="176"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="246" mass="28186" checksum="ABB35C61B072541E" modified="2004-07-19" version="1">MHLFDLRTLLAILVSICVVFQAFPLATVPLNKNLILGQYMGYHFGVFGWCFVDKGVTIACHCKFRPDSIETYKYTDQLLFPSLYKVTISTLLVVHPVSFAFTCILWIMALIIRLSRFGRCPIFILSAATWSLAAFLLALLSALVDLLLFVNKLKWPGWLVLASVPLMAICCSWLWSLRRQVSAIFYERKAYATQTYSRFDSMELSHIDTKFSDDQSIYETYTLERVPYSKNEAIEEPALTYYTSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV17</accession>
    <name>Q6FV17_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0E05478g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV17"/>
    <dbReference type="FunCoup" id="Q6FV17">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV17"/>
    <dbReference type="KEGG" id="cgr:2887565"/>
    <dbReference type="CGD" id="CAL0128572">
        <property type="gene designation" value="CAGL0E05478g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05478g"/>
    <dbReference type="eggNOG" id="KOG4134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060987_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FV17"/>
    <dbReference type="OMA" id="YMQTASH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000004">
        <property type="entry name" value="RNA polymerase I subunit Rpa43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="9">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="RPA43 OB" evidence="10">
        <location>
            <begin position="127"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0128572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="304" mass="34361" checksum="C2393FFAFAD3BEC6" modified="2004-07-19" version="1">MAQLKRSAEEIKKIKFIKRHKSQVKNPLDPKDGVSNCILKVPVALYVSLAPMYLKEPTNGIMKQHLDPMIMKYNSKVGGVVLGYDNLEIIDADPLNPSDAEEKLIKITPDTPFGYTWCHTDLYIWKPQVGDILEGHIFIQSASHIGILIHDAFNASIKKNNIPNDWSFIHNEDEEQEEQQDDENNKNNYNNRSIGHWVNANGETIDGKIKFRVRSVYTTGRVISVDGTLLDDPSIWGQGQSRSPAEKLPVVSNKKIIFDDEVSAENKETHQELEIPEPNENKEGEILYEENSSESSSDDSSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV26</accession>
    <name>Q6FV26_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GRE2(B)</name>
        <name evidence="4 5" type="ordered locus">CAGL0E05280g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445918.1">
        <property type="nucleotide sequence ID" value="XM_445918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV26"/>
    <dbReference type="SMR" id="Q6FV26"/>
    <dbReference type="FunCoup" id="Q6FV26">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV26"/>
    <dbReference type="GeneID" id="2887288"/>
    <dbReference type="KEGG" id="cgr:2887288"/>
    <dbReference type="CGD" id="CAL0129012">
        <property type="gene designation" value="GRE2(B)"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05280g"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_9_2_1"/>
    <dbReference type="InParanoid" id="Q6FV26"/>
    <dbReference type="OMA" id="IGREFRF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0129012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="351" mass="38969" checksum="EC75B4CD4E43035F" modified="2004-07-19" version="1">MTAANNNTTVFVSGASGFIAQHIIRQLLDQNYKVIGSVRSTEKGDNLKNAIFKSANFNYEIVKDIADLNAFDPVFEKHGKDIKVVLHTASPLNFTTTEYEKDLLIPAVNGTKGILESIKKYAAQTVERVVVTSSFASHTSTVDMCNTKGKITEDSWNQDSWENCQTDAVRAYFGSKKFAEEAAWEFLNKNKDAVKFKLATVDPVYVFGPQNHIEPGKKVLNVSSEVINQLVHLKKDDPLPQVACGYIDVRDIAKAHILAFQKDELIGQRLLLHSGLFTVQTLLDAINEQFPELRGKIPAGEPGSNKPEDLLTPIDNTKTKKLLGFEFRDLKTIIQDTVSQILEAENASAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVC8</accession>
    <name>Q6FVC8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Family 17 glucosidase SCW11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0E02915g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445816.1">
        <property type="nucleotide sequence ID" value="XM_445816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVC8"/>
    <dbReference type="FunCoup" id="Q6FVC8">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVC8"/>
    <dbReference type="CAZy" id="GH17">
        <property type="family name" value="Glycoside Hydrolase Family 17"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887425"/>
    <dbReference type="CGD" id="CAL0129052">
        <property type="gene designation" value="CAGL0E02915g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02915g"/>
    <dbReference type="eggNOG" id="ENOG502QS0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027285_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FVC8"/>
    <dbReference type="OMA" id="GCKSKAT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000160">
        <property type="entry name" value="Probable beta-glucosidase btgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF24">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273490" description="Family 17 glucosidase SCW11" evidence="9">
        <location>
            <begin position="21"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="100"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="105"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0129052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="52919" checksum="8CB763BFA7740BD3" modified="2004-07-19" version="1">MLPFIQLLYLALYLTSDVLAMPLRKREIVTRVHTASTTNTVTNFFSTTTQVIIAPTVQVIISGDTTLFSTMVGEGGDINAEPTTTITSIIQVKRVSLANEQPTATSTTPMLDSSSSSATTTSSAISSDITTTSIPSSSSIPTTTPSSSSSSSSSSSSIQSSSIRFASQVVNLENVEANQNQQKQEEQQHVHNTAHISTPVVEMTTTTSSSSTTTLEPTASQSSTSNNNADTTIKSAPIAIAYSPYNNDGTCKSADQVKEDLQLIKSKGINQIRMYGTDCNSLQTVLPNAKSIGLSVNQGLWITSSGVDSIDIPLQQLINYGQTNGWDVFAYITVGNEAVISQYCSVSDLVSKIGQVRGQLKAAGYTGQLTTSEPPVTYEQHPELCTASGIDFVGINPHAYFDTYSSADTAGSFVKGQIELVQKACGTGNIVVTETGYPSAGIQNGGNIPSKPNQLIAIQKILEATNNQVTLLSCFNDFWKAPGPYGIEQYFGILDNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVE8</accession>
    <name>Q6FVE8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0E02453g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVE8"/>
    <dbReference type="FunCoup" id="Q6FVE8">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVE8"/>
    <dbReference type="KEGG" id="cgr:2887495"/>
    <dbReference type="CGD" id="CAL0128804">
        <property type="gene designation" value="CAGL0E02453g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02453g"/>
    <dbReference type="eggNOG" id="KOG4392">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090381_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FVE8"/>
    <dbReference type="OMA" id="MNAPSRY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0128804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="120" mass="13558" checksum="BFCA660E89137E16" modified="2004-07-19" version="1">MNAPDRFELFLLGEGESKLKIDPDTKAPNAVVITFEKEDHTLGNLIRAELLNDNKVLFAAYKVEHPFFARFKLRIQTVEGYDPKDALRNACSSIINKLGALKSNFETEWNLQTLAADDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVF5</accession>
    <name>Q6FVF5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0E02299g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVF5"/>
    <dbReference type="FunCoup" id="Q6FVF5">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVF5"/>
    <dbReference type="KEGG" id="cgr:2887546"/>
    <dbReference type="CGD" id="CAL0128958">
        <property type="gene designation" value="CAGL0E02299g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02299g"/>
    <dbReference type="eggNOG" id="KOG0802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026577_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVF5"/>
    <dbReference type="OMA" id="SDNLCII"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000838">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-M complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="350"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="414"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0128958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG58708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="545" mass="61881" checksum="5172682870A25331" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVH7</accession>
    <name>Q6FVH7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">YPS6</name>
        <name evidence="10 11" type="ordered locus">CAGL0E01793g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445767.1">
        <property type="nucleotide sequence ID" value="XM_445767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVH7"/>
    <dbReference type="STRING" id="284593.Q6FVH7"/>
    <dbReference type="MEROPS" id="A01.030"/>
    <dbReference type="GeneID" id="2887357"/>
    <dbReference type="KEGG" id="cgr:2887357"/>
    <dbReference type="CGD" id="CAL0129054">
        <property type="gene designation" value="YPS6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01793g"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="InParanoid" id="Q6FVH7"/>
    <dbReference type="OMA" id="SHQGNGC"/>
    <dbReference type="PHI-base" id="PHI:7930"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="49"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0129054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="516" mass="55941" checksum="938862920AF1EBBA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVH9</accession>
    <name>Q6FVH9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">YPS4</name>
        <name evidence="11 12" type="ordered locus">CAGL0E01749g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445765.1">
        <property type="nucleotide sequence ID" value="XM_445765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVH9"/>
    <dbReference type="MEROPS" id="A01.030"/>
    <dbReference type="GeneID" id="2887370"/>
    <dbReference type="KEGG" id="cgr:2887370"/>
    <dbReference type="CGD" id="CAL0128780">
        <property type="gene designation" value="YPS4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01749g"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013253_9_1_1"/>
    <dbReference type="InParanoid" id="Q6FVH9"/>
    <dbReference type="OMA" id="TNEPIFP"/>
    <dbReference type="PHI-base" id="PHI:7928"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05470">
        <property type="entry name" value="pepsin_retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000011">
        <property type="entry name" value="Aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012384379" description="Peptidase A1 domain-containing protein" evidence="9">
        <location>
            <begin position="16"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="50"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="342"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0128780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="482" mass="53211" checksum="3720EBF88BA91533" modified="2004-07-19" version="1">MKYTLLLNLISCAQALLKLDFEKVPEQNLALNKRDDKGLQLELENGGLLYAVQLSVGTPPQNITVQLDTGSSDLWFTSEANPYCKNNRKHSPKKSQIEPLNDADYPTSPNQIPKSLRDIDCKAFGFFNTSKSSTYKNNGTNFTLSYADTTFASGPWGVDTLSFNGVKVDNVTFGLAAFSNSTTPVFGISLPARETTNQLAANGSRIGPNSYEYSNFPMLLKEQGIVKKIAYSVYLNDTRSKYGSILFGAVDQSKYIGTLYTLPLVNSLYKQVSKPFQFEITLNGIGLQTADKNYTLYDQKLATLLDTGVTTSVLPAKVAALVASKVNGTIDDDNGFIKLDKCPNKKEKRTVVFNFGGAEISIDIRDLTRKIKGKCYLQMQARDDIEFAALGDIFLRHVYVVYNLEDEEISIANANFNYSTPDIQEIVSTVPGAVKAPQYYNTYSVYPTATAVTGDVFTPEATMSMSNNSVALRKRTTLKPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVK8</accession>
    <name>Q6FVK8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear mRNA export factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0E01111g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the SAC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVK8"/>
    <dbReference type="FunCoup" id="Q6FVK8">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVK8"/>
    <dbReference type="KEGG" id="cgr:2887308"/>
    <dbReference type="CGD" id="CAL0128988">
        <property type="gene designation" value="CAGL0E01111g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01111g"/>
    <dbReference type="eggNOG" id="KOG1860">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006094_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVK8"/>
    <dbReference type="OMA" id="FQGTCLD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030029">
        <property type="term" value="P:actin filament-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000008">
        <property type="entry name" value="Nuclear mRNA export protein SAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017173">
        <property type="entry name" value="Sac3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024293">
        <property type="entry name" value="SAC3_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12209">
        <property type="entry name" value="SAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037320">
        <property type="entry name" value="mRNA_export_factor_Sac3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="247"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="488"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1079"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1013"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0128988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1195" mass="136668" checksum="75487F243DBAF3EB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVM2</accession>
    <name>Q6FVM2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SUP35</name>
        <name evidence="16 17" type="ordered locus">CAGL0E00781g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445722.1">
        <property type="nucleotide sequence ID" value="XM_445722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVM2"/>
    <dbReference type="FunCoup" id="Q6FVM2">
        <property type="interactions" value="984"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVM2"/>
    <dbReference type="GeneID" id="2887452"/>
    <dbReference type="KEGG" id="cgr:2887452"/>
    <dbReference type="CGD" id="CAL0128704">
        <property type="gene designation" value="SUP35"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00781g"/>
    <dbReference type="eggNOG" id="KOG0459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_8_1"/>
    <dbReference type="InParanoid" id="Q6FVM2"/>
    <dbReference type="OMA" id="ARFDECT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="261"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="66"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="164"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0128704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG58641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="688" mass="77999" checksum="3BA760D47B74E3D9" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVT4</accession>
    <name>Q6FVT4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0D05764g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVT4"/>
    <dbReference type="FunCoup" id="Q6FVT4">
        <property type="interactions" value="206"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVT4"/>
    <dbReference type="KEGG" id="cgr:2887174"/>
    <dbReference type="CGD" id="CAL0128301">
        <property type="gene designation" value="CAGL0D05764g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05764g"/>
    <dbReference type="eggNOG" id="KOG4775">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_304658_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVT4"/>
    <dbReference type="OMA" id="WDRATVR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018907">
        <property type="entry name" value="Spindle_body_associated_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10638">
        <property type="entry name" value="Sfi1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="261"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="582"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Spindle body associated protein C-terminal" evidence="3">
        <location>
            <begin position="772"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0128301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="103973" checksum="9FD5C8CEA6E41A69" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW05</accession>
    <name>Q6FW05_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="8">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="7">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0D03982g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="7"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW05"/>
    <dbReference type="FunCoup" id="Q6FW05">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW05"/>
    <dbReference type="KEGG" id="cgr:2887218"/>
    <dbReference type="CGD" id="CAL0128545">
        <property type="gene designation" value="CAGL0D03982g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03982g"/>
    <dbReference type="eggNOG" id="KOG2455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FW05"/>
    <dbReference type="OMA" id="FAGIHFT"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="78"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0128545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="574" mass="63787" checksum="FC434CC71FC218D4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWB6</accession>
    <name>Q6FWB6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0D01452g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWB6"/>
    <dbReference type="SMR" id="Q6FWB6"/>
    <dbReference type="FunCoup" id="Q6FWB6">
        <property type="interactions" value="849"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWB6"/>
    <dbReference type="KEGG" id="cgr:2887035"/>
    <dbReference type="CGD" id="CAL0128325">
        <property type="gene designation" value="CAGL0D01452g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01452g"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061288_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FWB6"/>
    <dbReference type="OMA" id="ARKMKEC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005823">
        <property type="term" value="C:central plaque of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990819">
        <property type="term" value="C:mating projection actin fusion focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045160">
        <property type="term" value="C:myosin I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:mitogen-activated protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032120">
        <property type="term" value="P:ascospore-type prospore membrane formation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:cell budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000742">
        <property type="term" value="P:karyogamy involved in conjugation with cellular fusion"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903525">
        <property type="term" value="P:regulation of membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051300">
        <property type="term" value="P:spindle pole body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000224">
        <property type="entry name" value="CMD1p Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0128325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="147" mass="16136" checksum="A39B7A59E2DFF479" modified="2004-07-19" version="1">MSSNLTEEQIAEFKEAFALFDKDNNGSISSSELATVMRSLGLSPSEAEVTDLMNEIDVDGNHQIEFSEFLALMSRQLKSNDSEQELLEAFKVFDKNGDGLISAAELKHVLTSIGEKLTDAEVDEMLREVSDGSGEINIQQFAALLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWD0</accession>
    <name>Q6FWD0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome B pre-mRNA-processing protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0D01144g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWD0"/>
    <dbReference type="FunCoup" id="Q6FWD0">
        <property type="interactions" value="162"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWD0"/>
    <dbReference type="KEGG" id="cgr:2887169"/>
    <dbReference type="CGD" id="CAL0128521">
        <property type="gene designation" value="CAGL0D01144g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01144g"/>
    <dbReference type="eggNOG" id="ENOG502SAQZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149479_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWD0"/>
    <dbReference type="OMA" id="PRYYDRI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005761">
        <property type="term" value="C:mitochondrial ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18273" checksum="E387E6D1AC7A60CF" modified="2004-07-19" version="1">MSTPPAVREAAKQVVKCLERFPADRFKHLTSFKDIQISRFNRIAGVSLKGEDAANEKKPSLSEVKDMISRTSGPLGLQKDFLKKLQGALQQDMVSEEGLTKQKRSLEVLMSDKYKNYYEVGDKLYKPNGNPEYYQRLMDELTGKKKENLFTGLRTVFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWQ6</accession>
    <name>Q6FWQ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0C03696g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWQ6"/>
    <dbReference type="FunCoup" id="Q6FWQ6">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886765"/>
    <dbReference type="CGD" id="CAL0127276">
        <property type="gene designation" value="CAGL0C03696g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03696g"/>
    <dbReference type="eggNOG" id="ENOG502QSRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016933_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWQ6"/>
    <dbReference type="OMA" id="IRYWNEF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:intracellular phosphate ion homeostasis"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:microautophagy"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="735"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="773"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="805"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0127276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="831" mass="95253" checksum="E51D13E2768B1C83" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWU8</accession>
    <name>Q6FWU8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein FUN14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0C02739g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FUN14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWU8"/>
    <dbReference type="FunCoup" id="Q6FWU8">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWU8"/>
    <dbReference type="KEGG" id="cgr:2886823"/>
    <dbReference type="CGD" id="CAL0127302">
        <property type="gene designation" value="CAGL0C02739g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02739g"/>
    <dbReference type="eggNOG" id="ENOG502S4F4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103433_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FWU8"/>
    <dbReference type="OMA" id="GWIRINL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007014">
        <property type="entry name" value="FUN14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04930">
        <property type="entry name" value="FUN14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0127302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21309" checksum="FE9A2811F661B0C0" modified="2004-07-19" version="1">MLLLGRFTGVGARRLFSMNAMRPLRSAMPMAWRRSGNVGLKTAFMGLAFAAPFSVSMLTPSRTIYNDTAVDIGANVLKQTGLSQAEVEVVKGERKVRLDYRGLCLGSILGVGAGVIIGKISGVLAYFTVFAFLVLQWMKNRGLIDKNSSQLRGLYRVAKVGFVDEEGNARFVNSENLCFKLSFLLTFLLAAVNTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWY8</accession>
    <name>Q6FWY8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0C01859g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58162.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445256.2">
        <property type="nucleotide sequence ID" value="XM_445256.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWY8"/>
    <dbReference type="STRING" id="284593.Q6FWY8"/>
    <dbReference type="KEGG" id="cgr:2886740"/>
    <dbReference type="CGD" id="CAL0127426">
        <property type="gene designation" value="CAGL0C01859g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C01859g"/>
    <dbReference type="eggNOG" id="KOG1688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052834_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWY8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0127426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58162.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="51112" checksum="CD46E2AFB079545A" modified="2008-09-23" version="2">METPCPPERRLHHMVFSRLPPKTRLDTAQLTKQKARSIVQRKAQRHKHKNTKHKTHTLRTMRTRPLISRVLKGWRIGCTLEDYKIEPDEMLSSKPDATLDHNDHKYKKLYRLCLAKSTAYTKLRWVVELSLVVLFLSRFKPLPDCYVYDGKWFDDLYCFLSGCTYGFVNDKVLQQYNEYLDVGEKPDVFHPILSRPSEFKFWHYCIRTTVYYILWELLVSQCRPLFWPLAFVLHSTYCLAYVFKVFLRSENPTHQFYLDVCKRHTMARWISGIGLLSFVLFLYRCHYAWELCYYALGISILDAFIMCLTRMHDIYSQQPKDNSQEANEASMEFRPYLRNSPEFILWCICIKHTVWFLVLSLFEVRYDQEDIVVFIFFYDVYWTVICVIKAVLLMNSYGTYQHRYVNEMRWLQDTMALDGVLKCPPCM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX31</accession>
    <name>RSA3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Ribosome assembly protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RSA3</name>
        <name type="ordered locus">CAGL0C00715g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with nucleolar pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RSA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445213.1">
        <property type="nucleotide sequence ID" value="XM_445213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX31"/>
    <dbReference type="SMR" id="Q6FX31"/>
    <dbReference type="FunCoup" id="Q6FX31">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX31"/>
    <dbReference type="EnsemblFungi" id="CAGL0C00715g-T">
        <property type="protein sequence ID" value="CAGL0C00715g-T-p1"/>
        <property type="gene ID" value="CAGL0C00715g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886879"/>
    <dbReference type="KEGG" id="cgr:2886879"/>
    <dbReference type="CGD" id="CAL0127294">
        <property type="gene designation" value="CAGL0C00715g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00715g"/>
    <dbReference type="eggNOG" id="ENOG502S5DP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119118_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX31"/>
    <dbReference type="OMA" id="DAHNNNK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051898">
        <property type="entry name" value="Ribosome_Assembly_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028217">
        <property type="entry name" value="Rsa3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28127:SF1">
        <property type="entry name" value="RIBOSOME ASSEMBLY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14615">
        <property type="entry name" value="Rsa3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000097463" description="Ribosome assembly protein 3">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="190" mass="21681" checksum="A0DDC729C4B83E05" modified="2004-07-19" version="1">MPSQEIFKTKQRKSTNRRRKKRRTAESESDSDSSSSSAASDIEMTNEEEKNDNNSPIISDVELSDLENESEKRDVYELDKETKNKLANIPLTRTEFTSRKDKSVPINLNAVQNKLEMSEEQLKDRIATDQSKEQDAYLNLMFENFGDELNAFRTASDFNSKTVNILANVLKDGTALFDNETLKSIVKSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX51</accession>
    <name>Q6FX51_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-lactate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HSP31</name>
        <name evidence="9 10" type="ordered locus">CAGL0C00275g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS). Important for viability in stationary phase. May negatively regulate TORC1 in response to nutrient limitation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="2"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445193.1">
        <property type="nucleotide sequence ID" value="XM_445193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX51"/>
    <dbReference type="FunCoup" id="Q6FX51">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX51"/>
    <dbReference type="GeneID" id="2886921"/>
    <dbReference type="KEGG" id="cgr:2886921"/>
    <dbReference type="CGD" id="CAL0127480">
        <property type="gene designation" value="HSP31"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00275g"/>
    <dbReference type="eggNOG" id="ENOG502RZ3Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070319_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FX51"/>
    <dbReference type="OMA" id="LHPFEVF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03147">
        <property type="entry name" value="GATase1_Ydr533c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000051">
        <property type="entry name" value="Glutathione-independent glyoxalase HSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="8">
        <location>
            <begin position="29"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0127480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="236" mass="25495" checksum="9A03005C64C01242" modified="2004-07-19" version="1">MAAKKVLLALTSYNGDFYEDGAKTGVFVVEAMHPFNLFTEKGFEVDFVSETGKYGWDEHSLIPDFLSGKDKEDFDNENSSFHKALKNVKAAKDVKASDYDIFFASAGHGTLFDYPKAKELQGLAEDIYANGGVVAAVCHGPAIFDGLKDKKTGKPLIEGKAITGFTDIGEVVLNVDKIMKDKGLLSVEDIAKKYGAKYLAPIGPWDDFSITDGKLVTGVNPASAHSTAQRAIDALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX54</accession>
    <name>Q6FX54_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AWP7</name>
        <name evidence="3 4" type="ordered locus">CAGL0C00209g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445190.1">
        <property type="nucleotide sequence ID" value="XM_445190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX54"/>
    <dbReference type="STRING" id="284593.Q6FX54"/>
    <dbReference type="GeneID" id="2886748"/>
    <dbReference type="KEGG" id="cgr:2886748"/>
    <dbReference type="CGD" id="CAL0127320">
        <property type="gene designation" value="AWP7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00209g"/>
    <dbReference type="eggNOG" id="ENOG502S6R6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_626983_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX54"/>
    <dbReference type="OMA" id="PETITMM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000992">
        <property type="entry name" value="SRP1_TIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00660">
        <property type="entry name" value="SRP1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273674" evidence="2">
        <location>
            <begin position="19"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="437" mass="44106" checksum="F64C8CAB5EC0BF33" modified="2004-07-19" version="1">MKLSKSLVAVYALIGVNAIDPTTTLAPTDFRVNMIELQAYLADIKGHMMQYLSFQGAHPDQPYPSQMIGAVMFGNTSPLSEIAPETITMMITGVPWYSERLIGAIASRLADEGIATAWPTSSSSTKTTTTMSTSNSSPTSISSSDSTASSDSTFSSSVSSSSSTSVTSSTSASSSTSVTSSTSASSSTSASSSTSASSSTSASSSTSASSSTSASSSTSASSSTSASSSSLYVSALSSVSASSSPSSHTSSVVASNSSSFPTLMSTVSSTESVTSHQEASLSSSVTISSSSVALTSKQTSSQNSAFANKTVSIPSPSTSIFTDTVGKTITKVITYCSETDNQGNVGTRTSSYTIDASNANLDATGSLVVSRETTTKSRRQDASEAITGKSHSLTSSVSVVELHSSAVISQYAGSAANLSCLSRIGALATLLALLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX84</accession>
    <name>Q6FX84_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0B00946g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX84"/>
    <dbReference type="STRING" id="284593.Q6FX84"/>
    <dbReference type="KEGG" id="cgr:2886572"/>
    <dbReference type="CGD" id="CAL0127160">
        <property type="gene designation" value="CAGL0B00946g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B00946g"/>
    <dbReference type="eggNOG" id="ENOG502S2FC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_702391_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX84"/>
    <dbReference type="OMA" id="GNDDNKY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG57912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="394" mass="42090" checksum="1CA783B6E7B5EE9C" modified="2004-07-19" version="1">MSSVDELIGQAERDIENGEHGNAISNLTRAAQSDPDERQMSMIERLLGMLVDYVRSRDGNGGDGSRDGSRDIGSGSGERGMGDSMMSALMSSSGGSSQAQLGKLALLGTMMGSGSGKQQSQGQGFNWGSALSLFSGQSGKQSAANAGTGALLASLASSYFKGSGSKPQQQQQQQGGSYGQQYGGNYQQHQPQQQESSTFSSIASMASNYFNKPQQGQGNGYGNQNQNAGSNQGHQNYGQNQGYNNQGQGSHGYGQNEYSNDGYGQSRPPQQQNQESGTFSSIMNMASSYMHKNDGQGQGRPPSNQYSNNGGGYGHGDGAYSNQSQNYGSNQNYGSNQNYGSNQNYSQPNHNQGYGNQEYGYNQGNDNYGRPQQQRPNNDNGEGFNFQGHFSNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXF5</accession>
    <name>Q6FXF5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0B02343g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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        <property type="component" value="Chromosome B"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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        <property type="entry name" value="AMINOTRIAZOLE RESISTANCE PROTEIN"/>
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        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
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        <property type="entry name" value="MFS_1"/>
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        <property type="entry name" value="MFS general substrate transporter"/>
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        <property type="entry name" value="MFS"/>
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    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    </feature>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG57972.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="537" mass="59014" checksum="E39A75BC8C15BF94" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXG1</accession>
    <name>Q6FXG1_CANGA</name>
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        <recommendedName>
            <fullName evidence="17">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CCH1</name>
        <name evidence="21 22" type="ordered locus">CAGL0B02211g</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="23">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.</text>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="16">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="CGD"/>
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        <property type="entry name" value="Volt_channel_dom_sf"/>
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        <location>
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            <end position="76"/>
        </location>
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        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
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        </location>
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            <begin position="288"/>
            <end position="304"/>
        </location>
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        </source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00057587"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0127760"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG57966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="2124" mass="246687" checksum="475747D44EC51667" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXL4</accession>
    <name>Q6FXL4_CANGA</name>
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        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0B04851g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QSNK">
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    </dbReference>
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    <dbReference type="InParanoid" id="Q6FXL4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007120">
        <property type="term" value="P:axial cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000755">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057454">
        <property type="entry name" value="Bud3_C"/>
    </dbReference>
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        <property type="entry name" value="Bud3_N"/>
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        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12015">
        <property type="entry name" value="Bud3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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        </location>
    </feature>
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            <end position="834"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="1092"/>
        </location>
    </feature>
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        <location>
            <begin position="1345"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="944"/>
            <end position="956"/>
        </location>
    </feature>
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        <location>
            <begin position="1070"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1346"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1540" mass="175200" checksum="0BA5C5DB5153A475" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXL6</accession>
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        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="12 13" type="ordered locus">CAGL0B04807g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
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        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="3">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXL6"/>
    <dbReference type="KEGG" id="cgr:2886711"/>
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    <dbReference type="Proteomes" id="UP000002428">
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    <dbReference type="GO" id="GO:0010494">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21607">
        <property type="entry name" value="RRM3_HRB1_GBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GBP2p Poly(A+) RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000508">
        <property type="entry name" value="Protein HRB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
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    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="119"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="222"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="341"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0127762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="419" mass="47351" checksum="ACD86E1B7749A3A0" modified="2004-07-19" version="1">MSDYPEYRSRSRSPSRRRLSVDDGMRAPRGGYGDAPRGRDRRYEDYRGDFRRGGYGGRRGSSRGRGFGGYRGYGAPPPRMGGRGFGRRGGYGHRPRGGPMMAREMEPPYEEKIDRNYDNSIFIGNLSFDATPEDLHDFFGQAGEVLRADIITSRGRHRGMGTVEFTSPEGVDNAIRDFNGVEFMGRPLFVRQDNPPPEPMESLPPMRERFNDYPPEGRPPMFEVFIVNLPYSMTWQTLKDLFREAGDVIRADIELDRNGFSRGFGTVFYGTQEEMFNAIERFNGFDVDGRILQVREGKNSTGYQAPYQAPPPPQEQEIEMEPPTGPSQFTENVVGGGERSTLIYCSNLPLTTATGDLYDLFETIGRVRHAELKFDESGAPTGIAVIEYENVEDADFCIQRLNNYNYGGCDLDISYAKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXS5</accession>
    <name>Q6FXS5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0A04521g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXS5"/>
    <dbReference type="FunCoup" id="Q6FXS5">
        <property type="interactions" value="1276"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXS5"/>
    <dbReference type="KEGG" id="cgr:2886292"/>
    <dbReference type="CGD" id="CAL0126633">
        <property type="gene designation" value="CAGL0A04521g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04521g"/>
    <dbReference type="eggNOG" id="KOG3283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080597_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FXS5"/>
    <dbReference type="OMA" id="QRPHYRK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018283">
        <property type="entry name" value="Ribosomal_eS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01193">
        <property type="entry name" value="RIBOSOMAL_S8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0126633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG57857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="201" mass="22440" checksum="30D5A44C854F189E" modified="2004-07-19" version="1">MGISRDSRHKRAATGAKRAQFRKKRKFELGRQPANTKIGGKRIHAVRTRGGNQKFRALRIETGNFSWASEGVAKKTRIVGVVYHPSNNELVRTNTLTKAAIVQIDATPFRQWYEAHYGQTLGKKKNAKTEEEVAKPSKSAERKWAARAASAKVESAVDSQFSAGRLYACISSRPGQSGRCDGYILEGEELAFYLRRLTAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXX4</accession>
    <name>Q6FXX4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="2 13">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EST2</name>
        <name evidence="15 16" type="ordered locus">CAGL0A00869g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Chromosome</location>
            <location evidence="13">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="2 13"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444808.1">
        <property type="nucleotide sequence ID" value="XM_444808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXX4"/>
    <dbReference type="FunCoup" id="Q6FXX4">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXX4"/>
    <dbReference type="GeneID" id="2886360"/>
    <dbReference type="KEGG" id="cgr:2886360"/>
    <dbReference type="CGD" id="CAL0126685">
        <property type="gene designation" value="EST2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A00869g"/>
    <dbReference type="eggNOG" id="KOG1005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012565_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXX4"/>
    <dbReference type="OMA" id="CYDSIPR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090399">
        <property type="term" value="P:replicative senescence"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd01648">
        <property type="entry name" value="TERT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01365">
        <property type="entry name" value="TELOMERASERT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 13" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9 13" id="KW-0779">Telomere</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="14">
        <location>
            <begin position="400"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0126685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG57699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="851" mass="98674" checksum="CCB0F339CEE446BD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXY1</accession>
    <name>Q6FXY1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0A00649g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444801.1">
        <property type="nucleotide sequence ID" value="XM_444801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXY1"/>
    <dbReference type="STRING" id="284593.Q6FXY1"/>
    <dbReference type="KEGG" id="cgr:2886463"/>
    <dbReference type="CGD" id="CAL0126603">
        <property type="gene designation" value="CAGL0A00649g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A00649g"/>
    <dbReference type="HOGENOM" id="CLU_1970244_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXY1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0126603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG57692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="127" mass="14626" checksum="CC37AFC922A24621" modified="2004-07-19" version="1">MKFIKFTIRSGAVGVYFNDIHIKISLRSINYTKLVSYNKPIPYQDRSIELLENSTSEVIQYKPCAPSHQGTNIKTTIIERQAMRFTKELSPEEIEFVDMSLSGMRPSVCEYLSHVSYRETGILSVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXZ9</accession>
    <name>Q6FXZ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DIP5</name>
        <name evidence="11 12" type="ordered locus">CAGL0A01199g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444823.1">
        <property type="nucleotide sequence ID" value="XM_444823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXZ9"/>
    <dbReference type="FunCoup" id="Q6FXZ9">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXZ9"/>
    <dbReference type="GeneID" id="2886303"/>
    <dbReference type="KEGG" id="cgr:2886303"/>
    <dbReference type="CGD" id="CAL0126839">
        <property type="gene designation" value="DIP5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01199g"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_1_1"/>
    <dbReference type="InParanoid" id="Q6FXZ9"/>
    <dbReference type="OMA" id="FWSVMVN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="94"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0126839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG57714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="613" mass="68748" checksum="856F48B14C7F0FA0" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY28</accession>
    <name>Q6FY28_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thioredoxin reductase</fullName>
            <ecNumber evidence="9">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TRR1</name>
        <name evidence="12 13" type="ordered locus">CAGL0A02530g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="9"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444874.1">
        <property type="nucleotide sequence ID" value="XM_444874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY28"/>
    <dbReference type="STRING" id="284593.Q6FY28"/>
    <dbReference type="GeneID" id="2886359"/>
    <dbReference type="KEGG" id="cgr:2886359"/>
    <dbReference type="CGD" id="CAL0126825">
        <property type="gene designation" value="TRR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02530g"/>
    <dbReference type="eggNOG" id="KOG0404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FY28"/>
    <dbReference type="OMA" id="ANKFYWI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000064">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="5"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0126825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG57767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="319" mass="34414" checksum="9D9C7AECDB1C6DD4" modified="2004-07-19" version="1">MPHNRVTIIGSGPAAHTAAIYLARAEMKPTLYEGMLANGIAAGGQLTTTTEIENFPGFPEGLTGTELMDRMRAQSTKFGTNIITETISKVDLSAKPFKLWTEFNEDGEPITTDAIVMATGASAKRLDLPGEDKYWQQGISACAVCDGAVPIFRNKPLAVVGGGDSACEEAEFLTKYGSKVFMIVRKDHLRASTIMQRRVEKNEKIEVLFNSVSLEAKGDGKFLNALRIKNVKTNEESDLPVNGLFYAIGHNPATDIVKGQVETDESGYIKTVPGSSLTSIPGFFAAGDVQDSRYRQAITSAGSGCMAALDAERYLTELE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY61</accession>
    <name>BCP1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">BCP1</name>
        <name type="ordered locus">CAGL0A02673g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BCP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444881.1">
        <property type="nucleotide sequence ID" value="XM_444881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY61"/>
    <dbReference type="SMR" id="Q6FY61"/>
    <dbReference type="FunCoup" id="Q6FY61">
        <property type="interactions" value="1058"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY61"/>
    <dbReference type="EnsemblFungi" id="CAGL0A02673g-T">
        <property type="protein sequence ID" value="CAGL0A02673g-T-p1"/>
        <property type="gene ID" value="CAGL0A02673g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886368"/>
    <dbReference type="KEGG" id="cgr:2886368"/>
    <dbReference type="CGD" id="CAL0126797">
        <property type="gene designation" value="CAGL0A02673g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_A02673g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02673g"/>
    <dbReference type="eggNOG" id="KOG3034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068770_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FY61"/>
    <dbReference type="OMA" id="VKFYRKE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000249699" description="Protein BCP1">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q06338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="276" mass="31648" checksum="B1543C937E6BC22C" modified="2004-07-19" version="1">MVQAIKLSELGNRKRRNDPVNEDEESEIDISSTDSEEENAGDEEQEIVNIDFDFFDGNPDVDFHAVKHLIRQLLGPQESNRVQLSALSDLILSSPTTTIKTDGKESDPYCFLSFINYKENKDSDYAKYLRKLDTRIETFLQTLDNTGNKSCALVMSERLINMPPEVVTPLYRITMEDAAAANEGKPFDFYVIVSRKYEVNFDMDEAEGDASARSKKRVRGKSEVDYFHEEDRFFEKHAKVHFDGESKKGLIASYIIIDHDSLVKSINEFEQEVSTW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-02-01" modified="2025-06-18" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q96WT3</accession>
    <accession>Q6FU48</accession>
    <name>FET3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Iron transport multicopper oxidase FET3</fullName>
            <ecNumber>1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FET3</name>
        <name type="ordered locus">CAGL0F06413g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2000-08" db="EMBL/GenBank/DDBJ databases">
            <title>Cloning and characterizing a multicopper oxidase gene from Candida glabrata.</title>
            <authorList>
                <person name="Tatsuno K."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>cg1012</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron transport multicopper ferroxidase required for Fe(2+) high affinity uptake. Required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="1">Binds 4 Cu cations per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
            <orientation evidence="3">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-"/>
    <dbReference type="EMBL" id="AB047078">
        <property type="protein sequence ID" value="BAB62813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446246.1">
        <property type="nucleotide sequence ID" value="XM_446246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q96WT3"/>
    <dbReference type="SMR" id="Q96WT3"/>
    <dbReference type="FunCoup" id="Q96WT3">
        <property type="interactions" value="788"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q96WT3"/>
    <dbReference type="GlyCosmos" id="Q96WT3">
        <property type="glycosylation" value="11 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0F06413g-T">
        <property type="protein sequence ID" value="CAGL0F06413g-T-p1"/>
        <property type="gene ID" value="CAGL0F06413g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887784"/>
    <dbReference type="KEGG" id="cgr:2887784"/>
    <dbReference type="CGD" id="CAL0131028">
        <property type="gene designation" value="FET3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06413g"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006504_7_3_1"/>
    <dbReference type="InParanoid" id="Q96WT3"/>
    <dbReference type="OMA" id="CDIAPGS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901684">
        <property type="term" value="P:arsenate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046688">
        <property type="term" value="P:response to copper ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000025">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0186">Copper</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0410">Iron transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000002957" description="Iron transport multicopper oxidase FET3">
        <location>
            <begin position="18"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="18"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="560"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="581"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like 1">
        <location>
            <begin position="42"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like 2">
        <location>
            <begin position="190"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like 3">
        <location>
            <begin position="382"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" description="type 2 copper site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 3 copper site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 3 copper site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 3 copper site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="1">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 2 copper site" evidence="1">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 3 copper site" evidence="1">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 3 copper site" evidence="1">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="1">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 3 copper site" evidence="1">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="type 1 copper site" evidence="1">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="635" mass="72020" checksum="6D6333BECFFD401F" modified="2001-12-01" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIP4</accession>
    <name>Q6FIP4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein ZIP4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M12815g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIP4"/>
    <dbReference type="FunCoup" id="Q6FIP4">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIP4"/>
    <dbReference type="KEGG" id="cgr:2891451"/>
    <dbReference type="CGD" id="CAL0136903">
        <property type="gene designation" value="CAGL0M12815g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M12815g"/>
    <dbReference type="eggNOG" id="KOG4814">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308367_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIP4"/>
    <dbReference type="OMA" id="ILMRMIM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="984" mass="114061" checksum="D3B7B253F1F2D267" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIS1</accession>
    <name>Q6FIS1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BolA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M12210g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIS1"/>
    <dbReference type="FunCoup" id="Q6FIS1">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIS1"/>
    <dbReference type="KEGG" id="cgr:2891423"/>
    <dbReference type="CGD" id="CAL0137201">
        <property type="gene designation" value="CAGL0M12210g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M12210g"/>
    <dbReference type="eggNOG" id="KOG2313">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109462_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FIS1"/>
    <dbReference type="OMA" id="FNDSYKH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990229">
        <property type="term" value="C:iron-sulfur cluster assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16350" checksum="8201EA96E4C4A5D9" modified="2004-07-19" version="1">MYRSVSRVPVFSISNLIKRNITKMSSETPLNMRTDGPVITSITTKIKAKFPDVEHLAVFNDSYKHKGHEPMETAENTTESHIRLEIVTEAFKGLNLPKRHRLVYGLLKEEFDDMGLHALQLTTKTPEEYAKSQQSSKAQTCKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIV6</accession>
    <name>Q6FIV6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M11440g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIV6"/>
    <dbReference type="KEGG" id="cgr:2891407"/>
    <dbReference type="CGD" id="CAL0136667">
        <property type="gene designation" value="CAGL0M11440g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11440g"/>
    <dbReference type="eggNOG" id="ENOG502QTSE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015811_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIV6"/>
    <dbReference type="OMA" id="PMAWYLS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF82">
        <property type="entry name" value="ACTIVATORY PROTEIN CHA4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="575" mass="65860" checksum="FB06F3FB0E610665" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIW6</accession>
    <name>Q6FIW6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22" type="ordered locus">CAGL0M11220g</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 18">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIW6"/>
    <dbReference type="SMR" id="Q6FIW6"/>
    <dbReference type="FunCoup" id="Q6FIW6">
        <property type="interactions" value="1077"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIW6"/>
    <dbReference type="KEGG" id="cgr:2891397"/>
    <dbReference type="CGD" id="CAL0137365">
        <property type="gene designation" value="CAGL0M11220g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11220g"/>
    <dbReference type="eggNOG" id="KOG2310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009535_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FIW6"/>
    <dbReference type="OMA" id="QNHTGHT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010791">
        <property type="term" value="P:DNA double-strand break processing involved in repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010780">
        <property type="term" value="P:meiotic DNA double-strand break formation involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062176">
        <property type="term" value="P:R-loop processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16 18" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 18" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 18" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 18" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="20">
        <location>
            <begin position="291"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="550"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="628"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000882-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0137365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG62808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="656" mass="74846" checksum="70A4539625C2C843" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIX6</accession>
    <name>Q6FIX6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminodeoxychorismate synthase</fullName>
            <ecNumber evidence="4">2.6.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-aminobenzoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">p-aminobenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0M10934g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.85" evidence="4"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIX6"/>
    <dbReference type="FunCoup" id="Q6FIX6">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIX6"/>
    <dbReference type="MEROPS" id="C26.958"/>
    <dbReference type="KEGG" id="cgr:2891385"/>
    <dbReference type="CGD" id="CAL0137349">
        <property type="gene designation" value="CAGL0M10934g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M10934g"/>
    <dbReference type="eggNOG" id="KOG1224">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIX6"/>
    <dbReference type="OMA" id="DWSVNIR"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008153">
        <property type="term" value="P:4-aminobenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010117">
        <property type="entry name" value="PabB_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01823">
        <property type="entry name" value="PabB-fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF18">
        <property type="entry name" value="AMINODEOXYCHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="270"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="488"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0137349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG62798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="773" mass="88181" checksum="9F80C0B627406B4A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ31</accession>
    <name>AIM36_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 36, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Found in mitochondria protein 39</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">AIM36</name>
        <name type="synonym">FMP39</name>
        <name type="ordered locus">CAGL0M09614g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIM36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449763.1">
        <property type="nucleotide sequence ID" value="XM_449763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ31"/>
    <dbReference type="FunCoup" id="Q6FJ31">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ31"/>
    <dbReference type="EnsemblFungi" id="CAGL0M09614g-T">
        <property type="protein sequence ID" value="CAGL0M09614g-T-p1"/>
        <property type="gene ID" value="CAGL0M09614g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891327"/>
    <dbReference type="KEGG" id="cgr:2891327"/>
    <dbReference type="CGD" id="CAL0137381">
        <property type="gene designation" value="CAGL0M09614g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09614g"/>
    <dbReference type="eggNOG" id="ENOG502S2G9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090420_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ31"/>
    <dbReference type="OMA" id="RVAIFPQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000399722" description="Altered inheritance of mitochondria protein 36, mitochondrial">
        <location>
            <begin position="34"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="230" mass="25556" checksum="B3FFF604241B6958" modified="2004-07-19" version="1" precursor="true">MALMRLGLRIPARLGSNLPVAQLGIRAAKHRFYATAPRNDGGELPSIKKLLMIGLAGTAVFVLAVNSLDKQQPKNSYSESEFESLQRLKRKVALFPGNQLKVYGVLGTEKYNKIVSGGKIVDPRKIIEKHRTTAGDRYEALLNILYDKYGAVEYFDMLPQGLMVKLVSLYMKDNCSEGDTVVILDFPKSIKDASQFETEVAGISKFIVSQKLKDTDICKYYDAVGKLESV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ48</accession>
    <name>CSN12_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>COP9 signalosome complex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CSN12</name>
        <name type="ordered locus">CAGL0M09251g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response.</text>
    </comment>
    <comment type="subunit">
        <text>Component of a COP9 signalosome-like (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449746.1">
        <property type="nucleotide sequence ID" value="XM_449746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ48"/>
    <dbReference type="SMR" id="Q6FJ48"/>
    <dbReference type="FunCoup" id="Q6FJ48">
        <property type="interactions" value="980"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ48"/>
    <dbReference type="EnsemblFungi" id="CAGL0M09251g-T">
        <property type="protein sequence ID" value="CAGL0M09251g-T-p1"/>
        <property type="gene ID" value="CAGL0M09251g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891310"/>
    <dbReference type="CGD" id="CAL0136487">
        <property type="gene designation" value="CAGL0M09251g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M09251g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09251g"/>
    <dbReference type="eggNOG" id="KOG2688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031567_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FJ48"/>
    <dbReference type="OMA" id="ESQTNWI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0736">Signalosome</keyword>
    <feature type="chain" id="PRO_0000121038" description="COP9 signalosome complex subunit 12">
        <location>
            <begin position="1"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="233"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="449" mass="52648" checksum="50065C165F8673FD" modified="2004-07-19" version="1">MEYSRFVDCFERRSYTAEFLEFVGFKLSSEPLGATALILGGSQAKQARYGDVNALYDAIVQIKLKESLTSLRELDPNAAVKKNKQRKVHQRVVDVFQALTNELRILNKILERSDDSVWLVYPVYTVCHDVSTFLRDTGKYMQLESRKQLWEECIRVIHRSFMICLNDKNPNMQENKRGGCILFANLEMMFYKMLRNRDMMKNLIKVLESTGMTDISRQRDNKVLKRHRSQKIIFNYFIGEYYGCYLFQFNKAQEHLQVCVSEFPVKYTSSKWFKRIIHLYTQFRMLATSNKLIHVELPRETNEKFANAYDSDLMNKCYKNGDTIVFDELIKEHAAQYLIDGTYSAMLLIKELVFLRLVKVCYKVNDKKSILPLDLIAAGYRIHFRNHDNEENRVTTTNPRKLQKKNEDLLDELECRIANLIANGRIKGYLSHSQRCMVLSKTEPFPLAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ70</accession>
    <name>AKR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Palmitoyltransferase AKR1</fullName>
            <ecNumber>2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Ankyrin repeat-containing protein AKR1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">AKR1</name>
        <name type="ordered locus">CAGL0M08712g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Early endosome membrane</location>
            <topology>Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449724.1">
        <property type="nucleotide sequence ID" value="XM_449724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ70"/>
    <dbReference type="SMR" id="Q6FJ70"/>
    <dbReference type="FunCoup" id="Q6FJ70">
        <property type="interactions" value="625"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ70"/>
    <dbReference type="EnsemblFungi" id="CAGL0M08712g-T">
        <property type="protein sequence ID" value="CAGL0M08712g-T-p1"/>
        <property type="gene ID" value="CAGL0M08712g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891285"/>
    <dbReference type="KEGG" id="cgr:2891285"/>
    <dbReference type="CGD" id="CAL0137231">
        <property type="gene designation" value="CAGL0M08712g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M08712g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08712g"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012510_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FJ70"/>
    <dbReference type="OMA" id="RECQSHS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090029">
        <property type="term" value="P:negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000301">
        <property type="entry name" value="Palmitoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0040">ANK repeat</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000212920" description="Palmitoyltransferase AKR1">
        <location>
            <begin position="1"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="326"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="423"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="568"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 2">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 3">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 4">
        <location>
            <begin position="159"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 5">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 6">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK 7">
        <location>
            <begin position="292"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="3">
        <location>
            <begin position="454"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="1">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="763" mass="85540" checksum="E5A42F43026BEA59" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJC7</accession>
    <name>LGE1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulatory protein LGE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LGE1</name>
        <name type="ordered locus">CAGL0M07337g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in transcriptional activation. Also required for ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Its precise role in H2BK123ub1 formation however is unclear.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449667.1">
        <property type="nucleotide sequence ID" value="XM_449667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJC7"/>
    <dbReference type="STRING" id="284593.Q6FJC7"/>
    <dbReference type="EnsemblFungi" id="CAGL0M07337g-T">
        <property type="protein sequence ID" value="CAGL0M07337g-T-p1"/>
        <property type="gene ID" value="CAGL0M07337g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891716"/>
    <dbReference type="KEGG" id="cgr:2891716"/>
    <dbReference type="CGD" id="CAL0136585">
        <property type="gene designation" value="CAGL0M07337g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07337g"/>
    <dbReference type="eggNOG" id="ENOG502SA4A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_888515_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJC7"/>
    <dbReference type="OMA" id="YSANSRH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22897">
        <property type="entry name" value="Lge1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021581">
        <property type="entry name" value="Tscrpt_reg_Lge1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11488">
        <property type="entry name" value="Lge1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000076232" description="Transcriptional regulatory protein LGE1">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="313" mass="34425" checksum="BE0A9BD496320FC8" modified="2004-07-19" version="1">MSDERYQSRYGRYDSGRGGRSGYYSNYQNSSHHRSNDGPNTNTHGPSNGNGNSGGYYHGYYNRHGSMNGRAASSGRGYYGGHNTHITSAPHNNPNAYSRAPATGNTSYTGSYYSRGGNSSGRGGYSSYNRGGYHASHQYNNGGYYHRNNNYNSSYTERQKSVSGDSATSGGMKYTSSHRTTHVTHPAHPPITIQRSGSNGNGVAQGNASSGEVPTAPRRETTAQNNGRDKREEQLKKYGISNMAQGYLEIMDQNSSSTTSVTQTEIELDEKLREMNSQVFRTMCELALVENQYTRDTLNVQLTQEKLDTLLLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJJ1</accession>
    <name>OAF3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Oleate activated transcription factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">OAF3</name>
        <name type="ordered locus">CAGL0M05907g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional inhibitor with a significantly increased number of target genes in response to oleate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OAF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449603.1">
        <property type="nucleotide sequence ID" value="XM_449603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJJ1"/>
    <dbReference type="SMR" id="Q6FJJ1"/>
    <dbReference type="FunCoup" id="Q6FJJ1">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJJ1"/>
    <dbReference type="EnsemblFungi" id="CAGL0M05907g-T">
        <property type="protein sequence ID" value="CAGL0M05907g-T-p1"/>
        <property type="gene ID" value="CAGL0M05907g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891651"/>
    <dbReference type="KEGG" id="cgr:2891651"/>
    <dbReference type="CGD" id="CAL0136453">
        <property type="gene designation" value="CAGL0M05907g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05907g"/>
    <dbReference type="eggNOG" id="ENOG502QQCV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018684_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJJ1"/>
    <dbReference type="OMA" id="WCAPEDG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF33">
        <property type="entry name" value="OLEATE ACTIVATED TRANSCRIPTION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000409038" description="Oleate activated transcription factor 3">
        <location>
            <begin position="1"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="891" mass="103392" checksum="53BC76A7C20514B3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJL0</accession>
    <name>Q6FJL0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M05467g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJL0"/>
    <dbReference type="FunCoup" id="Q6FJL0">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJL0"/>
    <dbReference type="ESTHER" id="canga-q6fjl0">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891631"/>
    <dbReference type="CGD" id="CAL0137361">
        <property type="gene designation" value="CAGL0M05467g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05467g"/>
    <dbReference type="eggNOG" id="ENOG502QVGS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068926_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJL0"/>
    <dbReference type="OMA" id="YRKLWQF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="77"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="354" mass="41047" checksum="F9844D26D15747A9" modified="2004-07-19" version="1">MEVLREACSLEGELVNGRVDDILAKYEQVPQRELSRVIDSRDFEVRFLKERTRVVTLDGIDMRCFDNIRDGERRDSVFLLIHGLGGSMDQFQPLMKLLTLLKYRVIALDLPGFGQSGSSTNGYDMLYVTSVVKKVVDNNIENKTDIDFKVVGHSMGCYIASHFVQMYHEEYNIDKLVLTCPPPPSISTLRQDNYIMKMAMRGLMWAPFIFNIYRVWFDQSKGLNSSGIMNFFSANTETFQDEETENKNLKFRKLWQFSNNIKIDTSTIFSYFLGWKFPDWEDLDNIINTNNVELVVIYAEHDKITPKQDAQLIFDAFKNVAATKKKLLEITNCGHNIFFNCPEKACKLFQEQVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJW1</accession>
    <name>Q6FJW1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M03135g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJW1"/>
    <dbReference type="FunCoup" id="Q6FJW1">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJW1"/>
    <dbReference type="KEGG" id="cgr:2891491"/>
    <dbReference type="CGD" id="CAL0137125">
        <property type="gene designation" value="CAGL0M03135g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03135g"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008578_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJW1"/>
    <dbReference type="OMA" id="DIINHTW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:early endosome"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903577">
        <property type="term" value="P:cellular response to L-arginine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000397">
        <property type="term" value="P:positive regulation of ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="420"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1073" mass="118786" checksum="1A2C58E223E3AEFD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK37</accession>
    <name>Q6FK37_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M01430g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK37"/>
    <dbReference type="FunCoup" id="Q6FK37">
        <property type="interactions" value="1048"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK37"/>
    <dbReference type="KEGG" id="cgr:2891176"/>
    <dbReference type="CGD" id="CAL0137177">
        <property type="gene designation" value="CAGL0M01430g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01430g"/>
    <dbReference type="eggNOG" id="KOG2048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002392_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FK37"/>
    <dbReference type="OMA" id="STYITEW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000896">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="751" mass="84929" checksum="29E680493552CF11" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKH3</accession>
    <name>SBE22_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein SBE22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SBE22</name>
        <name type="ordered locus">CAGL0L11572g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With SBE2, is involved in cell wall integrity and polarity processes like bud growth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SBE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449271.1">
        <property type="nucleotide sequence ID" value="XM_449271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKH3"/>
    <dbReference type="SMR" id="Q6FKH3"/>
    <dbReference type="FunCoup" id="Q6FKH3">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKH3"/>
    <dbReference type="EnsemblFungi" id="CAGL0L11572g-T">
        <property type="protein sequence ID" value="CAGL0L11572g-T-p1"/>
        <property type="gene ID" value="CAGL0L11572g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890971"/>
    <dbReference type="KEGG" id="cgr:2890971"/>
    <dbReference type="CGD" id="CAL0135442">
        <property type="gene designation" value="CAGL0L11572g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11572g"/>
    <dbReference type="eggNOG" id="ENOG502QR4N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019068_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKH3"/>
    <dbReference type="OMA" id="WWNILER"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031403">
        <property type="entry name" value="Sbe2/Sbe22_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053949">
        <property type="entry name" value="SBE2/SBE22_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053948">
        <property type="entry name" value="SBE2/SBE22_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17076">
        <property type="entry name" value="SBE2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22874">
        <property type="entry name" value="SBE2_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22876">
        <property type="entry name" value="SBE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000320508" description="Protein SBE22">
        <location>
            <begin position="1"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="169"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="813" mass="92043" checksum="F3A11057F4F23FBF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKP1</accession>
    <name>Q6FKP1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAGL0L09911g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62173.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891086"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09911g"/>
    <dbReference type="eggNOG" id="ENOG502SFJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_251278_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKP1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049451">
        <property type="entry name" value="AWP2-like_YTTT_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20646">
        <property type="entry name" value="Hpf1_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273431" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1375"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62173.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1451" mass="156237" checksum="2C805415505D1437" modified="2008-09-23" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKS8</accession>
    <name>SPB4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent rRNA helicase SPB4</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SPB4</name>
        <name type="ordered locus">CAGL0L08976g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449166.1">
        <property type="nucleotide sequence ID" value="XM_449166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKS8"/>
    <dbReference type="SMR" id="Q6FKS8"/>
    <dbReference type="FunCoup" id="Q6FKS8">
        <property type="interactions" value="1286"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKS8"/>
    <dbReference type="EnsemblFungi" id="CAGL0L08976g-T">
        <property type="protein sequence ID" value="CAGL0L08976g-T-p1"/>
        <property type="gene ID" value="CAGL0L08976g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891097"/>
    <dbReference type="KEGG" id="cgr:2891097"/>
    <dbReference type="CGD" id="CAL0135944">
        <property type="gene designation" value="CAGL0L08976g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08976g"/>
    <dbReference type="eggNOG" id="KOG0345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_26_4_1"/>
    <dbReference type="InParanoid" id="Q6FKS8"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232325" description="ATP-dependent rRNA helicase SPB4">
        <location>
            <begin position="1"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="38"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="252"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="4">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box" evidence="4">
        <location>
            <begin position="172"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="617" mass="70790" checksum="1E33D196D4FCE603" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKV9</accession>
    <name>Q6FKV9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0L08250g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKV9"/>
    <dbReference type="FunCoup" id="Q6FKV9">
        <property type="interactions" value="1087"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKV9"/>
    <dbReference type="KEGG" id="cgr:2890562"/>
    <dbReference type="CGD" id="CAL0135812">
        <property type="gene designation" value="CAGL0L08250g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08250g"/>
    <dbReference type="eggNOG" id="KOG1123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008213_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKV9"/>
    <dbReference type="OMA" id="RCQEIDY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000019">
        <property type="term" value="P:regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001111">
        <property type="term" value="P:RNA polymerase II promoter clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001113">
        <property type="term" value="P:transcription open complex formation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="393"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="609"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0135812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG62105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="862" mass="97438" checksum="A2146AEA68834D97" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLC9</accession>
    <name>PNS1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PNS1</name>
        <name type="ordered locus">CAGL0L04378g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448965.1">
        <property type="nucleotide sequence ID" value="XM_448965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLC9"/>
    <dbReference type="SMR" id="Q6FLC9"/>
    <dbReference type="FunCoup" id="Q6FLC9">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLC9"/>
    <dbReference type="GlyCosmos" id="Q6FLC9">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0L04378g-T">
        <property type="protein sequence ID" value="CAGL0L04378g-T-p1"/>
        <property type="gene ID" value="CAGL0L04378g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890635"/>
    <dbReference type="KEGG" id="cgr:2890635"/>
    <dbReference type="CGD" id="CAL0135642">
        <property type="gene designation" value="CAGL0L04378g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04378g"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026724_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLC9"/>
    <dbReference type="OMA" id="DTIFVAM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000191732" description="Protein PNS1">
        <location>
            <begin position="1"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="169"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="415"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="topological domain" description="Extracellular" evidence="2">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="510"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="557" mass="62610" checksum="F4F72FEFD23BE910" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLN9</accession>
    <name>Q6FLN9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">CAGL0L01969g</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLN9"/>
    <dbReference type="FunCoup" id="Q6FLN9">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLN9"/>
    <dbReference type="KEGG" id="cgr:2890677"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_0_1"/>
    <dbReference type="InParanoid" id="Q6FLN9"/>
    <dbReference type="OMA" id="FHHMVMG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG61825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26365" checksum="1736E384D41D5DCA" modified="2004-07-19" version="1">MLDLFERVKACLFDMDGLLINTEDIYTLTLNRILKEYGLGPLTWDVKIQLQGLPGPEAGKKIIETYKLPLTPKELETKNIEIQNDYWPTAAFLPGALELLKYLKSKNIPIALCTSSNKIKFKGKTSHLGEGFNLFDAIVTGDDERIPSGRGKPFPDVWQVGLKSLNDKFNTSISPSECLVFEDGIIGVQSGRAFGAHVIWVPHQESLPFIDNAADVLQGQGEQLNTLEELELSKYGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-06" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLY9</accession>
    <name>BST1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>GPI inositol-deacylase</fullName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">BST1</name>
        <name type="ordered locus">CAGL0K12408g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448755.1">
        <property type="nucleotide sequence ID" value="XM_448755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLY9"/>
    <dbReference type="SMR" id="Q6FLY9"/>
    <dbReference type="FunCoup" id="Q6FLY9">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLY9"/>
    <dbReference type="ESTHER" id="canga-q6fly9">
        <property type="family name" value="PGAP1"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q6FLY9">
        <property type="glycosylation" value="10 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0K12408g-T">
        <property type="protein sequence ID" value="CAGL0K12408g-T-p1"/>
        <property type="gene ID" value="CAGL0K12408g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889984"/>
    <dbReference type="KEGG" id="cgr:2889984"/>
    <dbReference type="CGD" id="CAL0133825">
        <property type="gene designation" value="CAGL0K12408g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12408g"/>
    <dbReference type="eggNOG" id="KOG3724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006103_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLY9"/>
    <dbReference type="OMA" id="WVRNLAV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034368">
        <property type="term" value="P:protein-lipid complex remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000277633" description="GPI inositol-deacylase">
        <location>
            <begin position="1"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="717"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="847"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="964"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="654"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="837"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="898"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="949"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1011" mass="115797" checksum="413C16BFF84A8FD5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLZ8</accession>
    <name>Q6FLZ8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Carrier protein YMC1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0K12210g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLZ8"/>
    <dbReference type="FunCoup" id="Q6FLZ8">
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    </dbReference>
    <dbReference type="KEGG" id="cgr:2889975"/>
    <dbReference type="CGD" id="CAL0134647">
        <property type="gene designation" value="CAGL0K12210g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12210g"/>
    <dbReference type="eggNOG" id="KOG0758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_16_2_1"/>
    <dbReference type="InParanoid" id="Q6FLZ8"/>
    <dbReference type="OMA" id="ATFVTFE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000163">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF51">
        <property type="entry name" value="CARRIER PROTEIN YMC2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="127"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="222"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0134647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34240" checksum="F98E3E917B607F4B" modified="2004-07-19" version="1">MSEEFPTPQLLNELEDVPPPTPYGRVVKDIFAGTMGGVAQVLVGQPFDTTKVRLQTSKTKIGVIEVVQNLLRNEGALAFYKGMLTPLLGVGICVSVQFGVNESMKRFFAAYNADRVDPQKHVPLPLHQYYLCGLTGGVVNSFLAAPIEHVRIRLQTQTSQGNERQFKGPFDCIKKLAKAKALMRGLLPTMIRAGHGLGTYFAAYEALVVKEFEKGTPRNQIPAWKLCSFGALSGTILWLTVYPVDVVKSVLQTDSIENPKYKNSIIKATRALYKQHGIPAFFKGFVPTMIRAAPANAATFVSFEMTMRVLG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM00</accession>
    <name>EXO84_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Exocyst complex component EXO84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EXO84</name>
        <name type="ordered locus">CAGL0K12166g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
        <text evidence="1">Cell periphery. The polarization of EXO84 requires actin cables (By similarity).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EXO84 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448744.1">
        <property type="nucleotide sequence ID" value="XM_448744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM00"/>
    <dbReference type="SMR" id="Q6FM00"/>
    <dbReference type="FunCoup" id="Q6FM00">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM00"/>
    <dbReference type="EnsemblFungi" id="CAGL0K12166g-T">
        <property type="protein sequence ID" value="CAGL0K12166g-T-p1"/>
        <property type="gene ID" value="CAGL0K12166g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889972"/>
    <dbReference type="KEGG" id="cgr:2889972"/>
    <dbReference type="CGD" id="CAL0134525">
        <property type="gene designation" value="CAGL0K12166g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12166g"/>
    <dbReference type="eggNOG" id="KOG2215">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014732_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM00"/>
    <dbReference type="OMA" id="AAWLPNR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001927">
        <property type="term" value="P:exocyst assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0268">Exocytosis</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="chain" id="PRO_0000118979" description="Exocyst complex component EXO84">
        <location>
            <begin position="1"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="479"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="1">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="764" mass="86315" checksum="756789BE5D90DF00" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="150" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM06</accession>
    <name>Q6FM06_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P-type Na(+) transporter</fullName>
            <ecNumber evidence="19">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ENA1</name>
        <name evidence="24 25" type="ordered locus">CAGL0K12034g</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="19"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM06"/>
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    <proteinExistence type="inferred from homology"/>
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            <end position="1041"/>
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            <dbReference type="EMBL" id="CAG61701.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1087" mass="120280" checksum="723508E4DA380836" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM52</accession>
    <name>Q6FM52_CANGA</name>
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        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly protein COX14</fullName>
        </recommendedName>
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        <name evidence="6 7" type="ordered locus">CAGL0K10956g</name>
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    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="protein sequence ID" value="CAG61655.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome K"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:negative regulation of mitochondrial translation"/>
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        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0133865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="7641" checksum="03292CE4824D4F11" modified="2004-07-19" version="1">MARYAWYTRATDTLHRLTVLTIIGGSLYMTGGLVYTLYMNGKRYEQKVITDKKDEMNQLEGAVSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM70</accession>
    <name>Q6FM70_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0K10472g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM70"/>
    <dbReference type="FunCoup" id="Q6FM70">
        <property type="interactions" value="1035"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM70"/>
    <dbReference type="KEGG" id="cgr:2890095"/>
    <dbReference type="CGD" id="CAL0134223">
        <property type="gene designation" value="CAGL0K10472g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10472g"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_6_1"/>
    <dbReference type="InParanoid" id="Q6FM70"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071232">
        <property type="term" value="P:cellular response to histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071264">
        <property type="term" value="P:positive regulation of translational initiation in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006448">
        <property type="term" value="P:regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000882">
        <property type="entry name" value="Translation initiation regulator (Gcn20)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="199"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="532"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="283"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0134223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="752" mass="84814" checksum="865E3D35461D57F6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMB7</accession>
    <name>Q6FMB7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0K09372g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMB7"/>
    <dbReference type="FunCoup" id="Q6FMB7">
        <property type="interactions" value="544"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMB7"/>
    <dbReference type="KEGG" id="cgr:2890259"/>
    <dbReference type="CGD" id="CAL0134765">
        <property type="gene designation" value="CAGL0K09372g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09372g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039422_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMB7"/>
    <dbReference type="OMA" id="HICCIDE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900436">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0134765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="396" mass="42374" checksum="91D1A12C9B3ED1A7" modified="2004-07-19" version="1">MAKRPVRLPSDNKERPFKCEHCSRGFHRLEHKKRHMRTHTGEKPHGCSFPGCGKSFSRSDELKRHNRTHTGVSQKKKKTKGKGAKIQDPMAGEEKLVELVNVQFPVPYTSVQNGETNMSPPIPGSQPISIPIANPLPHPTSGVYFNVQPGTSPLVAIAQQQLGMVNYHGYPTVAASESITPVPILSTSASSVALSDMSHTSSAFSNIGGGHSGAGSLSTSPSSMNDVYLNCNSNNLPHKVNNTTNPCAPTLPPVINITNSAVGYNNVLNSLQNKTSKANSRVTKAEKGGPLLSTSPIDIKPLSTNNSSTSLVALLKSDASLAPLKKGPLQLASSTRSTAKYLDGVSDGDDNRYYSQGDEDQDDDTDTCTTPRENIKITLPPLSNLIKGIEIFNGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN00</accession>
    <name>Q6FN00_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NFACT RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0K03883g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN00"/>
    <dbReference type="FunCoup" id="Q6FN00">
        <property type="interactions" value="566"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN00"/>
    <dbReference type="KEGG" id="cgr:2890144"/>
    <dbReference type="CGD" id="CAL0134141">
        <property type="gene designation" value="CAGL0K03883g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03883g"/>
    <dbReference type="eggNOG" id="KOG3272">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076656_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FN00"/>
    <dbReference type="OMA" id="YHDEKAV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0134141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="204" mass="24310" checksum="F3B2BDC121416383" modified="2004-07-19" version="1">MVYFYESQPELGYDGYQVIIGKDKFENDLLIKYGYRELNYMWFHTDKYSSGHVYLKMKESEKSLGDVPKAVVEDCLQLCKSESIQGNKMPECTIIYTPWHNLRKNRYMKPGEVSFKSVKNCKKTVCYNRDNKILNRLSKTRVEIYDDVEKLLHEAKKSKDPNYFTDYISRNRDSLVEAEKVRKQLSKLAKQKKKKETEEEFYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN23</accession>
    <name>Q6FN23_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LAF1</name>
        <name evidence="5 6" type="ordered locus">CAGL0K03377g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN23"/>
    <dbReference type="FunCoup" id="Q6FN23">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890172"/>
    <dbReference type="CGD" id="CAL0133829">
        <property type="gene designation" value="LAF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03377g"/>
    <dbReference type="eggNOG" id="KOG0283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008245_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN23"/>
    <dbReference type="OMA" id="FHPNDDR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="408"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="448"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="834"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
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        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="859"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0133829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG61332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="978" mass="108521" checksum="E3F42B7F14F4EFE7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN57</accession>
    <name>Q6FN57_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING finger protein ETP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0K02563g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN57"/>
    <dbReference type="FunCoup" id="Q6FN57">
        <property type="interactions" value="784"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN57"/>
    <dbReference type="KEGG" id="cgr:2890263"/>
    <dbReference type="CGD" id="CAL0134389">
        <property type="gene designation" value="CAGL0K02563g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02563g"/>
    <dbReference type="eggNOG" id="KOG0804">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009969_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FN57"/>
    <dbReference type="OMA" id="RFNSIEP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045471">
        <property type="term" value="P:response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12717">
        <property type="entry name" value="RRM_ETP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034931">
        <property type="entry name" value="ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="247"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="8">
        <location>
            <begin position="281"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="446"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="586" mass="68323" checksum="550DFA56268A1321" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN61</accession>
    <name>Q6FN61_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DSS4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DSS4</name>
        <name evidence="4 5" type="ordered locus">CAGL0K02475g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448333.1">
        <property type="nucleotide sequence ID" value="XM_448333.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FN61">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN61"/>
    <dbReference type="GeneID" id="2890310"/>
    <dbReference type="KEGG" id="cgr:2890310"/>
    <dbReference type="CGD" id="CAL0134287">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02475g"/>
    <dbReference type="eggNOG" id="KOG4113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124782_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN61"/>
    <dbReference type="OMA" id="GPIGMVC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007515">
        <property type="entry name" value="Mss4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13276:SF0">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04421">
        <property type="entry name" value="Mss4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51796">
        <property type="entry name" value="MSS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0134287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17072" checksum="3D714EC7A7736688" modified="2004-07-19" version="1">MASTGKVRKARCQFTECASSLISVPAVDSKTTDRLIYFPGAIMEKYKIMETREGADAQKEYEFLVVPEFWDFDNIGVSRDLCQVTEDRDNAEFKFEWDGHTWELIHCQRYLACAECDRGPIGLLCEVQDANDHSSTRKICLLSIASVDCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN73</accession>
    <name>Q6FN73_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K02211g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN73"/>
    <dbReference type="FunCoup" id="Q6FN73">
        <property type="interactions" value="1208"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN73"/>
    <dbReference type="KEGG" id="cgr:2890298"/>
    <dbReference type="CGD" id="CAL0134305">
        <property type="gene designation" value="CAGL0K02211g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02211g"/>
    <dbReference type="eggNOG" id="KOG3117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065858_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN73"/>
    <dbReference type="OMA" id="RHTKSER"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="351" mass="40117" checksum="5B6A59A680FAD369" modified="2004-07-19" version="1">MSLKSTLREINESLKATSESLDKLQDQYESGLPIEGGLKKYLGKDGSGNEQVSLLTLKNDSMLAYLNSLLHILHDKMDRTGERVTADGHRERTIEHRVVLERGVKPLEKKISYQLDKLTRAYTRMEKEYTDAEKRAAEKSAHREAEDSDSADDSSDEELSYRPNASALVASKDKTSRDRKNKGDEGEGDESGEDEEKSGVYRPPKINAVLPPQQHHFEDRFVARDHKNKSNRSRMQAMEDYIKENSEQPDWESSIGANIVNHGRGGVKSLRDTEKERQVTTYEEENFTRLNVGSSSAEKRKQKQRERNAKVNIIGGEDFSIFNSKRKLEDSTSRRGNKKSRNAWDRAKRRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN88</accession>
    <name>FBRL_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>rRNA 2'-O-methyltransferase fibrillarin</fullName>
            <ecNumber>2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">NOP1</name>
        <name type="ordered locus">CAGL0K01859g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles that contain SNU13, NOP1, SIK1/NOP56 and NOP58, plus a guide RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <text evidence="1">Fibrillar region of the nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448306.1">
        <property type="nucleotide sequence ID" value="XM_448306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN88"/>
    <dbReference type="SMR" id="Q6FN88"/>
    <dbReference type="FunCoup" id="Q6FN88">
        <property type="interactions" value="1190"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN88"/>
    <dbReference type="EnsemblFungi" id="CAGL0K01859g-T">
        <property type="protein sequence ID" value="CAGL0K01859g-T-p1"/>
        <property type="gene ID" value="CAGL0K01859g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890032"/>
    <dbReference type="KEGG" id="cgr:2890032"/>
    <dbReference type="CGD" id="CAL0134523">
        <property type="gene designation" value="CAGL0K01859g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K01859g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01859g"/>
    <dbReference type="eggNOG" id="KOG1596">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059055_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FN88"/>
    <dbReference type="OMA" id="WNPNKSK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000148522" description="rRNA 2'-O-methyltransferase fibrillarin">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="219"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="modified residue" description="Asymmetric dimethylarginine" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="323" mass="34129" checksum="8D60BD39C3A6A9D4" modified="2004-07-19" version="1">MSFRPGSRGGARGGRGGSRGGFGGRGGSRGGFGGRGGSRGGSRGGFGGRGGSRGGPRGGSRGGPRGGARGGARGGAKGGAKVVIEPHKHDGVYIARGKEDLLVTKNMAPGESVYGEKRVSVEEPSKEDGVPPTKVEYRVWNPFRSKLAAGIMGGLDELFIAPGKKVLYLGAASGTSVSHVSDVVGPEGVVYAVEFSHRPGRELISMAKKRPNVIPIIEDARHPQKYRMLVGMVDAVFADVAQPDQARIIALNSHMFLKDQGGVVISIKANCIDSTVDAETVFAREVQKLREEKIKPLEQLTLEPYERDHCIVIGRYMRSGLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNA0</accession>
    <name>Q6FNA0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Actin-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K01595g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNA0"/>
    <dbReference type="FunCoup" id="Q6FNA0">
        <property type="interactions" value="1155"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNA0"/>
    <dbReference type="KEGG" id="cgr:2890020"/>
    <dbReference type="CGD" id="CAL0134549">
        <property type="gene designation" value="CAGL0K01595g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01595g"/>
    <dbReference type="eggNOG" id="KOG0677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027965_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FNA0"/>
    <dbReference type="OMA" id="WEDMQHL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44232" checksum="385546610395DFFD" modified="2004-07-19" version="1">MDPHNPIVLDQGTGFVKIGRAGENFPDYTFPSIVGRPILRAEERATINKPLKDIMIGDEASDVRSYLQISYPMENGIIKNWTDMELLWDYAFFNQMQLPTTSGGKILLTEPPMNPVKNREQMCEVMFEKYDFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESVVLNHLTRRLDVAGRDVTRHLIDLLSRRGYAFNRSADFETVRQIKEKLCYVSYDLDLDTKLARETTTLVENYELPDGRIIKVGQERFEAPECLFQPNLVDVEQAGIGELLFNTIQSADVDVRSSLYKAIVLSGGSSMYPGLPSRLEKELKQLWFTRVLNNDPTRLDKFKVRIEDPPRRRHMVFIGGAVLASIMADKDHMWLTKQEWRESGAAAMSKFGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNE1</accession>
    <name>Q6FNE1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">40S ribosomal protein S14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0K00671g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNE1"/>
    <dbReference type="FunCoup" id="Q6FNE1">
        <property type="interactions" value="1057"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNE1"/>
    <dbReference type="KEGG" id="cgr:2890227"/>
    <dbReference type="CGD" id="CAL0134445">
        <property type="gene designation" value="CAGL0K00671g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00671g"/>
    <dbReference type="eggNOG" id="KOG0407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_6_0_1"/>
    <dbReference type="InParanoid" id="Q6FNE1"/>
    <dbReference type="OMA" id="IYASHND"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0134445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14666" checksum="BCFC1963C574C477" modified="2004-07-19" version="1">MAKDLVQSRDASQVFGVARIYASFNDTFVHVTDLSGRETISRVTGGMKVKADRDESSPYAAMLAAQDVAAKCLEVGITAVHVKIRATGGTRTKTPGPGGQAALRALARSGLRIGRIEDVTPVPSDSTRKKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNE6</accession>
    <name>Q6FNE6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0K00539g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNE6"/>
    <dbReference type="FunCoup" id="Q6FNE6">
        <property type="interactions" value="616"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNE6"/>
    <dbReference type="KEGG" id="cgr:2890184"/>
    <dbReference type="CGD" id="CAL0134771">
        <property type="gene designation" value="CAGL0K00539g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00539g"/>
    <dbReference type="eggNOG" id="KOG0937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026996_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FNE6"/>
    <dbReference type="OMA" id="KPLIWCD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099638">
        <property type="term" value="P:endosome to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="175"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="456" mass="52352" checksum="1669EB8407FD6176" modified="2004-07-19" version="1">MASAIYFCDNKGRPLLSRKYRDDIPFSAIDRFPILLSNFEEETNLIPPCIEHNGIQFLFIQHNDLYLVAIATSISCNAALIFSFLHKVIEVLSEYLKAVEEESIRDNFVIIYELLDEMMDYGIPQITEPKMLKQYITQKSFKLKKAAKKKRNAARPPTSLTNSVSWRPEGIKHKKNEAFLDIIESINMLMTQKGQVLRSEIIGEVKVKSKLSGMPDLKLGINDKGLFSKYLEGDENGVPIAPDDSSVDESKPKKKRSNNMELEDLKFHQCVRLSKFENEKQITFIPPDGDFELMSYRLSTAIKPLIWCDVNIKTHSKSRIEIFCRAKAQIKKKSTATNVEILIPVPEDADTPVFKYSHGSIKYVPEKNAILWKIRTFPGDKEYSMAAEMGLPSTNAGEESEKLKRPVQVKFQIPYFTTSGIQVRYLKIEEKNLQYKSYPWVRYITKSGDDYTIRLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNU4</accession>
    <name>SEC31_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein transport protein SEC31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SEC31</name>
        <name type="ordered locus">CAGL0J08998g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">COPII-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448100.1">
        <property type="nucleotide sequence ID" value="XM_448100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNU4"/>
    <dbReference type="SMR" id="Q6FNU4"/>
    <dbReference type="FunCoup" id="Q6FNU4">
        <property type="interactions" value="779"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNU4"/>
    <dbReference type="EnsemblFungi" id="CAGL0J08998g-T">
        <property type="protein sequence ID" value="CAGL0J08998g-T-p1"/>
        <property type="gene ID" value="CAGL0J08998g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889475"/>
    <dbReference type="KEGG" id="cgr:2889475"/>
    <dbReference type="CGD" id="CAL0133638">
        <property type="gene designation" value="CAGL0J08998g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08998g"/>
    <dbReference type="eggNOG" id="KOG0307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003033_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FNU4"/>
    <dbReference type="OMA" id="AQWAFGG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070863">
        <property type="term" value="P:positive regulation of protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021614">
        <property type="entry name" value="Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009917">
        <property type="entry name" value="SRA1/Sec31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11549">
        <property type="entry name" value="Sec31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07304">
        <property type="entry name" value="SRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0931">ER-Golgi transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000295433" description="Protein transport protein SEC31">
        <location>
            <begin position="1"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="60"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="207"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="261"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 8; interaction with SEC13" evidence="2">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="960"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1037"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1129"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="1281" mass="139375" checksum="CC08FF57DEBD236B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-18" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNU6</accession>
    <name>PPID_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Peptidyl-prolyl cis-trans isomerase D</fullName>
            <shortName>PPIase D</shortName>
            <ecNumber>5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Rotamase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CPR6</name>
        <name type="ordered locus">CAGL0J08954g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448098.1">
        <property type="nucleotide sequence ID" value="XM_448098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNU6"/>
    <dbReference type="SMR" id="Q6FNU6"/>
    <dbReference type="FunCoup" id="Q6FNU6">
        <property type="interactions" value="1181"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNU6"/>
    <dbReference type="EnsemblFungi" id="CAGL0J08954g-T">
        <property type="protein sequence ID" value="CAGL0J08954g-T-p1"/>
        <property type="gene ID" value="CAGL0J08954g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889473"/>
    <dbReference type="KEGG" id="cgr:2889473"/>
    <dbReference type="CGD" id="CAL0129771">
        <property type="gene designation" value="CPR6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08954g"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_37_0_1"/>
    <dbReference type="InParanoid" id="Q6FNU6"/>
    <dbReference type="OMA" id="EMEQNCN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000045">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <keyword id="KW-0802">TPR repeat</keyword>
    <feature type="chain" id="PRO_0000232945" description="Peptidyl-prolyl cis-trans isomerase D">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 1">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 2">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 3">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="371" mass="41646" checksum="2FCCF06AFD0EEA8B" modified="2004-07-19" version="1">MTRPKAYFDISIGGTPKGRIVFELYKDVVPKTAENFLKLCEGKSGMAKSKPDVPLSYKGSIFHRVIKDFMIQFGDFTNFDGTGGESIYGEKFEDENFEIKHDKPFLLSMANAGPNTNGSQAFITCVPTPHLDGKHVVFGEVIEGKRLVRLIEKQQTEDGTDKPMHDVKVEGCGLLPDDYEVPADAEQTPTDEFGDNYEESLKDDAKVDLKKVETVIKAIETVKDIGTKQFKEQNYEVALAKYKKCDKFLKEYFPDDLNEEDMKKINDFKVTVPLNIAIAALKSKDYRSVMVACSEVLYAEAADAKAKAKALYRRGLAYYHVNDTDMALADLEMATTFQPNDAAIAKAINDTIKKRKQETEKQKKSLSKMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNW0</accession>
    <name>Q6FNW0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J08657g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNW0"/>
    <dbReference type="FunCoup" id="Q6FNW0">
        <property type="interactions" value="625"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNW0"/>
    <dbReference type="KEGG" id="cgr:2889670"/>
    <dbReference type="CGD" id="CAL0133038">
        <property type="gene designation" value="CAGL0J08657g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08657g"/>
    <dbReference type="eggNOG" id="KOG0700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021928_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FNW0"/>
    <dbReference type="OMA" id="DHNAWNP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="152"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="557" mass="62127" checksum="EE1F3F0C5347F4E2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNZ4</accession>
    <name>RTC4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RTC4</name>
        <name type="ordered locus">CAGL0J07876g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448050.1">
        <property type="nucleotide sequence ID" value="XM_448050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNZ4"/>
    <dbReference type="SMR" id="Q6FNZ4"/>
    <dbReference type="FunCoup" id="Q6FNZ4">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNZ4"/>
    <dbReference type="EnsemblFungi" id="CAGL0J07876g-T">
        <property type="protein sequence ID" value="CAGL0J07876g-T-p1"/>
        <property type="gene ID" value="CAGL0J07876g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889857"/>
    <dbReference type="KEGG" id="cgr:2889857"/>
    <dbReference type="CGD" id="CAL0133756">
        <property type="gene designation" value="CAGL0J07876g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07876g"/>
    <dbReference type="eggNOG" id="ENOG502S1RG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818877_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNZ4"/>
    <dbReference type="OMA" id="WESHIRT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000408795" description="Restriction of telomere capping protein 4">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="339" mass="38599" checksum="56AB97E8657A1030" modified="2004-07-19" version="1">MEDSIDLQRESLNKLIPESGSDDTSSSDEVNGLPTSSDGADDVSLINSEDLNSSLLKSDPGGTNKSDQTKNDETDSNDDQRIVLSGGVELEEVQETVKVYNNVKQALLEVETTDESQLILDKIKRDSQYSSDTECESRDADSELEDIQLEFRSKYPQLQIPYSDELCVKIIPYLDIVYDILSGVVTSMYYTRAKRAAMDSKKAFLSAEDFRNLDINLFTAGYFGLRRQLKVGNIIYEKFRDELARSKSPKIQWWGPIDFANYVLAPEVLVSFVLDTCQNKRSVQLTSRQDVYELFDNTTYYGNTVTDNEPLESWELSRKKRKYGPTNNQKTHKTRKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP27</accession>
    <name>Q6FP27_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0J07150g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448017.1">
        <property type="nucleotide sequence ID" value="XM_448017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP27"/>
    <dbReference type="STRING" id="284593.Q6FP27"/>
    <dbReference type="KEGG" id="cgr:2889571"/>
    <dbReference type="CGD" id="CAL0132926">
        <property type="gene designation" value="CAGL0J07150g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07150g"/>
    <dbReference type="eggNOG" id="ENOG502QW20">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008453_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP27"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089716">
        <property type="term" value="C:Pip2-Oaf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071400">
        <property type="term" value="P:cellular response to oleic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032000">
        <property type="term" value="P:positive regulation of fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF29">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="944"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0132926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1022" mass="115914" checksum="2D046242CDD91D72" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPC8</accession>
    <name>Q6FPC8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J04840g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPC8"/>
    <dbReference type="FunCoup" id="Q6FPC8">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPC8"/>
    <dbReference type="KEGG" id="cgr:2889558"/>
    <dbReference type="CGD" id="CAL0132896">
        <property type="gene designation" value="CAGL0J04840g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04840g"/>
    <dbReference type="eggNOG" id="KOG3159">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FPC8"/>
    <dbReference type="OMA" id="KCAVIGK"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="138"/>
            <end position="322"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
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            <dbReference type="CGD" id="CAL0132896"/>
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    <evidence type="ECO:0000313" key="8">
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    <sequence length="412" mass="47073" checksum="10846A4AD0B37B6C" modified="2004-07-19" version="1">MLKLGTRLLPALPARRTSMVRYMATNTPFDLDESDPKYKELNTMYEEMFSGETVPYMSNDATDEVSEVDLLNEEIDSLYNVGMNNPRHIKINTSTELNKLIKGEGPFVLRSISHNPYFNLALEDYLFRNTPIDKNSKSFDSHRLVFYINNKCAVIGKNQNIWEELHLQKLKEKGYEVLRRLSGGGAVLHDLGNVNYSYICSRDEFDTKYFNGRIVSWLKQYNHALPVSLNQRGDILSNGFKISGSAYKVALGKAYHHGTMLIKSNLSDFKGLLKPDIIEGINWETNSVVSVRSPIENLPLPSPDTFIDLCTSQFNKMFHLNNNSYVCNESVMENNDDIKETMQKLQSNDWKYHSGPKFKVHIRDSKTGKEHSIAVEKGFIVDSTLKGVEAQDFNNFLHNVDKYITVNKANIL</sequence>
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    <name>Q6FPH0_CANGA</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2008" name="Chem. Biol." volume="15" first="990" last="996">
            <title>Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase.</title>
            <authorList>
                <person name="Liu J."/>
                <person name="Bolstad D.B."/>
                <person name="Smith A.E."/>
                <person name="Priestley N.D."/>
                <person name="Wright D.L."/>
                <person name="Anderson A.C."/>
            </authorList>
            <dbReference type="PubMed" id="18804036"/>
            <dbReference type="DOI" id="10.1016/j.chembiol.2008.07.013"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH NADPH</scope>
    </reference>
    <reference evidence="13 14 15" key="3">
        <citation type="journal article" date="2009" name="Chem. Biol. Drug Des." volume="73" first="62" last="74">
            <title>Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors.</title>
            <authorList>
                <person name="Liu J."/>
                <person name="Bolstad D.B."/>
                <person name="Smith A.E."/>
                <person name="Priestley N.D."/>
                <person name="Wright D.L."/>
                <person name="Anderson A.C."/>
            </authorList>
            <dbReference type="PubMed" id="19152636"/>
            <dbReference type="DOI" id="10.1111/j.1747-0285.2008.00745.x"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH NADPH</scope>
    </reference>
    <reference evidence="16 17 18" key="4">
        <citation type="journal article" date="2011" name="Chem. Biol. Drug Des." volume="78" first="505" last="512">
            <title>Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity.</title>
            <authorList>
                <person name="Paulsen J.L."/>
                <person name="Bendel S.D."/>
                <person name="Anderson A.C."/>
            </authorList>
            <dbReference type="PubMed" id="21726415"/>
            <dbReference type="DOI" id="10.1111/j.1747-0285.2011.01169.x"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) IN COMPLEX WITH NADPH</scope>
    </reference>
    <reference evidence="19 20 21" key="5">
        <citation type="journal article" date="2013" name="Bioorg. Med. Chem. Lett." volume="23" first="1279" last="1284">
            <title>Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.</title>
            <authorList>
                <person name="Paulsen J.L."/>
                <person name="Viswanathan K."/>
                <person name="Wright D.L."/>
                <person name="Anderson A.C."/>
            </authorList>
            <dbReference type="PubMed" id="23375226"/>
            <dbReference type="DOI" id="10.1016/j.bmcl.2013.01.008"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 3-217 IN COMPLEX WITH NADPH</scope>
    </reference>
    <reference evidence="22" key="6">
        <citation type="journal article" date="2014" name="J. Med. Chem." volume="57" first="2643" last="2656">
            <title>Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata.</title>
            <authorList>
                <person name="G-Dayanandan N."/>
                <person name="Paulsen J.L."/>
                <person name="Viswanathan K."/>
                <person name="Keshipeddy S."/>
                <person name="Lombardo M.N."/>
                <person name="Zhou W."/>
                <person name="Lamb K.M."/>
                <person name="Sochia A.E."/>
                <person name="Alverson J.B."/>
                <person name="Priestley N.D."/>
                <person name="Wright D.L."/>
                <person name="Anderson A.C."/>
            </authorList>
            <dbReference type="PubMed" id="24568657"/>
            <dbReference type="DOI" id="10.1021/jm401916j"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH NADPH</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dihydrofolate reductase family.</text>
    </comment>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 14">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 14">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0133636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="3CSE"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="3EEJ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="3EEK"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="3EEL"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="3QLX"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="3QLY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="3QLZ"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="3RO9"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="3ROA"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="4H98"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="4HOG"/>
        </source>
    </evidence>
    <sequence length="217" mass="25050" checksum="AF1E7DC86BB5BE80" modified="2004-07-19" version="1">MSKVPVVGIVAALLPEMGIGFQGNLPWRLAKEMKYFREVTTLTNDNSKQNVVIMGRKTWESIPQKFRPLPKRINVVVSRSFDGELRKVEDGIYHSNSLRNCLTALQSSLANENKIERIYIIGGGEIYRQSMDLADHWLITKIMPLPETTIPQMDTFLQKQELEQRFYDNSDKLVDFLPSSIQLEGRLTSQEWNGELVKGLPVQEKGYQFYFTLYTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPQ0</accession>
    <name>Q6FPQ0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0J02046g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447794.1">
        <property type="nucleotide sequence ID" value="XM_447794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPQ0"/>
    <dbReference type="KEGG" id="cgr:2889785"/>
    <dbReference type="CGD" id="CAL0132876">
        <property type="gene designation" value="CAGL0J02046g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02046g"/>
    <dbReference type="HOGENOM" id="CLU_2605798_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPQ0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="79" mass="9090" checksum="BD50596BD25C3FA6" modified="2004-07-19" version="1">MLYSRRRNCTGSKDLCFHAQLQDLSDIGALLFTLEFTGKRYTYYIFLRQTLQTVWPLWTGSVLPHWIYSIASVGGPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPT0</accession>
    <name>Q6FPT0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J01221g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPT0"/>
    <dbReference type="FunCoup" id="Q6FPT0">
        <property type="interactions" value="786"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPT0"/>
    <dbReference type="KEGG" id="cgr:2889833"/>
    <dbReference type="CGD" id="CAL0129669">
        <property type="gene designation" value="CAGL0J01221g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01221g"/>
    <dbReference type="eggNOG" id="KOG2485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011106_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FPT0"/>
    <dbReference type="OMA" id="GVLWPKF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902775">
        <property type="term" value="P:mitochondrial large ribosomal subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01856">
        <property type="entry name" value="YlqF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="3">
        <location>
            <begin position="149"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0129669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="351" mass="40199" checksum="7CB82E358AF6784F" modified="2004-07-19" version="1">MSYRCYSSLSFVPRHVLPRFNIPKSDFKGHQVKAIKKFKKLSPGLNMLIELRDIRAPLSTRNVIFDNILRSNRSLERLVVYTKKDMTSGNANGKQYFKKLSQWHAQLNEKFIILDGRDTSDAKQLLKILQWENHKVESRGMRLPLGYRAFIAGMPNVGKSTLVNTLRRVTNPSSSGTKFKKVARTGSEAGVTRSTSEVIRLMPTTNNSSPIYLIDSPGVGLPGRLTNQNRMLTLSMCGAVKTSLIEPVIQADYLLYLMNLQNPLPGAEWYPKYKSEPTNDIYEVLRRLAKNKESFDENVVATNWVNKWRLDSKNLLFDVETLLPADAFSYRDYVDKQLEELGELTFLRERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPV0</accession>
    <name>Q6FPV0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J00737g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPV0"/>
    <dbReference type="FunCoup" id="Q6FPV0">
        <property type="interactions" value="896"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPV0"/>
    <dbReference type="KEGG" id="cgr:2889865"/>
    <dbReference type="CGD" id="CAL0133344">
        <property type="gene designation" value="CAGL0J00737g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J00737g"/>
    <dbReference type="eggNOG" id="KOG1779">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130128_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FPV0"/>
    <dbReference type="OMA" id="CASILCQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0133344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="82" mass="8879" checksum="3AA80736D9A2191A" modified="2004-07-19" version="1">MVLVQDLLHPTAASEARKHKLKTLVQAPRSYFLDVKCPGCLNITTVFSHAQTAVTCESCSTVLCTPTGGKAKLSEGTSFRRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ36</accession>
    <name>HSM3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>DNA mismatch repair protein HSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HSM3</name>
        <name type="ordered locus">CAGL0I09460g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S5B/HSM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447658.1">
        <property type="nucleotide sequence ID" value="XM_447658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ36"/>
    <dbReference type="SMR" id="Q6FQ36"/>
    <dbReference type="FunCoup" id="Q6FQ36">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ36"/>
    <dbReference type="EnsemblFungi" id="CAGL0I09460g-T">
        <property type="protein sequence ID" value="CAGL0I09460g-T-p1"/>
        <property type="gene ID" value="CAGL0I09460g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888931"/>
    <dbReference type="KEGG" id="cgr:2888931"/>
    <dbReference type="CGD" id="CAL0132546">
        <property type="gene designation" value="CAGL0I09460g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09460g"/>
    <dbReference type="eggNOG" id="ENOG502QWEK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044760_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ36"/>
    <dbReference type="OMA" id="YMEQMVL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12794">
        <property type="entry name" value="Hsm3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040752">
        <property type="entry name" value="HSM3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041335">
        <property type="entry name" value="HSM3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18794">
        <property type="entry name" value="HSM3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18795">
        <property type="entry name" value="HSM3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000301757" description="DNA mismatch repair protein HSM3">
        <location>
            <begin position="1"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="481" mass="55648" checksum="BCB88838D5FD0E43" modified="2004-07-19" version="1">MEQVFLEINEKLPGLLTTGGSDATFAESSKLIERCNLALISFTGTPTAVMDDTIKLMKSILASNESYNIDYDQLMDLMSQMVIKYPFDRILELFTVEELALALNSPIERLNIMTCVVVEYSEPSGLFASTTLIDILLQKYLDEDSSVNLVNSIEKVWKKTAQDELIRRRILENNYNFLSEVKNNEPNSLVFTRLLELLKICFTYLKSTEFRNSLFLISKKMIMDAVKDNILVFISICEYFTSIFSIVQDQKSQNPSKIICVRNCENTIMLFGDLFQNRSEFPDIEQFALSYLFKMFKILSYFDDLIVFEKLDNGYIHIEDGNEYLTDFLSFISPQYLYKKHLNIIKSKGHVRPSEISIIRNLCMSSDCFDIIKKNITAEDILAMPYLEQMILLEKMSQYDYSVKFLAQHLPKVMGSLISKDVKELLDRETFDFRLQVINNLIEWDVEQLHIWYEPLTEAKAQCMGTFASKDVGTKIESSFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-07" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ55</accession>
    <name>ECO1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>N-acetyltransferase ECO1</fullName>
            <ecNumber>2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Establishment of cohesion protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ECO1</name>
        <name type="ordered locus">CAGL0I09042g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by acetylating the cohesin complex component SMC3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ECO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447639.1">
        <property type="nucleotide sequence ID" value="XM_447639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ55"/>
    <dbReference type="SMR" id="Q6FQ55"/>
    <dbReference type="FunCoup" id="Q6FQ55">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ55"/>
    <dbReference type="EnsemblFungi" id="CAGL0I09042g-T">
        <property type="protein sequence ID" value="CAGL0I09042g-T-p1"/>
        <property type="gene ID" value="CAGL0I09042g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889020"/>
    <dbReference type="KEGG" id="cgr:2889020"/>
    <dbReference type="CGD" id="CAL0132682">
        <property type="gene designation" value="CAGL0I09042g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09042g"/>
    <dbReference type="eggNOG" id="KOG3014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039183_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FQ55"/>
    <dbReference type="OMA" id="PSITHQE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061733">
        <property type="term" value="F:protein-lysine-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034089">
        <property type="term" value="P:establishment of meiotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032200">
        <property type="term" value="P:telomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070058">
        <property type="term" value="P:tRNA gene clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028005">
        <property type="entry name" value="AcTrfase_ESCO_Znf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028009">
        <property type="entry name" value="ESCO_Acetyltransf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45884:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE ECO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13880">
        <property type="entry name" value="Acetyltransf_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13878">
        <property type="entry name" value="zf-C2H2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000074546" description="N-acetyltransferase ECO1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="102"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CCHH-type">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="261" mass="29527" checksum="8193FEDEC8A00300" modified="2004-07-19" version="1">MAVNHVRSKSSNGKRLVQSKLNINNETILKCPKCEMKYSPNSIDDVATHKKYHDLHINGRNWSQTWGIPIHDTTSSTIIATPSSSPFKTGKSVNNKNNERIVMIQENKPAEVKAMLEIMDIVNQELNAPQDENNFWRKPNAEHQGKAIVYIKDKKVVGAITVEVLKQHKCRWMIYETRTLVEHVRPQFTLGISRIWVCRAQRGKGIAEKLLDAARISAIPGQNVDKMKLAWSQPSDSGGKLAKKYNGVKHKSGHILIPCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQE6</accession>
    <name>Q6FQE6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum membrane protein 65</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0I06853g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQE6"/>
    <dbReference type="FunCoup" id="Q6FQE6">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889072"/>
    <dbReference type="CGD" id="CAL0132590">
        <property type="gene designation" value="CAGL0I06853g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06853g"/>
    <dbReference type="eggNOG" id="KOG2490">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003655_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FQE6"/>
    <dbReference type="OMA" id="YHDVRGQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="473"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0132590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="62643" checksum="AC4700CEF0B0EB8A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQH1</accession>
    <name>Q6FQH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0I06270g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQH1"/>
    <dbReference type="FunCoup" id="Q6FQH1">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQH1"/>
    <dbReference type="KEGG" id="cgr:2889155"/>
    <dbReference type="CGD" id="CAL0132306">
        <property type="gene designation" value="CAGL0I06270g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06270g"/>
    <dbReference type="eggNOG" id="KOG4116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156007_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FQH1"/>
    <dbReference type="OMA" id="AGIYWYW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0132306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="94" mass="10922" checksum="81306C928BBF59F3" modified="2004-07-19" version="1">MSPPGAKAYMGWWGHLGSPKQKGITSYSVSPYAQKPLAHSMHNAVFNTFRRVKSQALYVLIPAGIYYYWWINSRDYNEYLYTKAGREELERVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQN6</accession>
    <name>Q6FQN6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0I04796g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQN6"/>
    <dbReference type="FunCoup" id="Q6FQN6">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQN6"/>
    <dbReference type="KEGG" id="cgr:2889365"/>
    <dbReference type="CGD" id="CAL0132744">
        <property type="gene designation" value="CAGL0I04796g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04796g"/>
    <dbReference type="eggNOG" id="KOG2792">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050131_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FQN6"/>
    <dbReference type="OMA" id="MLYFRVE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="109"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="147"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0132744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="294" mass="33346" checksum="BA611250B8E33BEC" modified="2004-07-19" version="1">MIRNVTNIARTRLLTRRVMQQPARPILAATRTFCNSAVVREKKLSRVPLTGRPKGSEPEHGIETSNSIEFSTGKAIALFLVVGGVSYYVFTNEKKKLEARKEAEANRGYGKPSLGGPFTLVDTEGKEFTEKNLRGKFSIVYFGFSHCPDICPDELDKLGEWLDVLDKKHDIHLQPIFITCDPARDSPEVLKQYLSDFHDGIIGLTGTYDQVKHACKQYRVYFSTPPNVKPGQDYLVDHSIFFYLMDPEGNFVEALGRNYDETTGVDKIVQQVRAYQPESERNKAKNSWLSFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQP1</accession>
    <name>Q6FQP1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ATP3</name>
        <name evidence="14 15" type="ordered locus">CAGL0I04686g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447453.1">
        <property type="nucleotide sequence ID" value="XM_447453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQP1"/>
    <dbReference type="FunCoup" id="Q6FQP1">
        <property type="interactions" value="1029"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQP1"/>
    <dbReference type="GeneID" id="2889360"/>
    <dbReference type="KEGG" id="cgr:2889360"/>
    <dbReference type="CGD" id="CAL0132562">
        <property type="gene designation" value="ATP3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04686g"/>
    <dbReference type="eggNOG" id="KOG1531">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FQP1"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140260">
        <property type="term" value="F:mitochondrial proton-transporting ATP synthase complex binding"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11 13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0132562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="296" mass="32675" checksum="80CE25FD2806D059" modified="2004-07-19" version="1">MLSRNIINGSRSIAWASTRNYATLKEVETRLKSIKNIEKITKTMKIVASTRLSKAEKAKLAAKKMDAADKQFYNNAETKPLEAEGETPKELVIAITSDKGLCGAIHSQLAKAVRRHLAEAPQADVVTIGDKIKTQLLRSNPDNLKFSINGVGKEAPTFEESSLIADKILTELNAGIYPKISIYYNDPISSLSFEPTSKPVFNPETIEQSPSYSKFEIDADNKVSRDLFEYTLANQIMTAMAEGYAAEISARRNAMDNASKNAGDMINRYSILYNRTRQAVITNELVDIITGASSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQQ3</accession>
    <name>Q6FQQ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0I04422g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQQ3"/>
    <dbReference type="FunCoup" id="Q6FQQ3">
        <property type="interactions" value="436"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQQ3"/>
    <dbReference type="KEGG" id="cgr:2889050"/>
    <dbReference type="CGD" id="CAL0132358">
        <property type="gene designation" value="CAGL0I04422g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04422g"/>
    <dbReference type="eggNOG" id="KOG0591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_23_1"/>
    <dbReference type="InParanoid" id="Q6FQQ3"/>
    <dbReference type="OMA" id="YKCHYGE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000525">
        <property type="entry name" value="Serine/threonine-protein kinase KIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="14"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="332"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0132358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="422" mass="49017" checksum="09B19D28CAB76F9F" modified="2004-07-19" version="1">MYKNQPQHYARSDYQVVKEIGRGSFGSVHKVIHVPTQQVLVRKDIKYGHMNSKERQQLIAECTILSQLKHENIVEFYSWDFNEQQEVLYLYMEYCSRGDLSGMIKHYKQEHKYIPEKVVWGILAQMLTALYKCHYGEELPSLTTIYDRMKPPSKGRNIVIHRDLKPGNIFLSYDDNSSDSTDKADIAQSNWYRKPNNRGGDESKLTTDYSQVVVKVGDFGLAKSLATSVDFATTYVGTPYYMSPEVLMDQPYSPLSDIWSLGCVIYEMCSLHPPFLAKNYLELQTKIKTGKFDNIPEYYSKGLNAIIHSMIDVNMKTRPSTFELLQDIQVRTARKSLQLERFEKNLLAYENELVNIEKILEKQAMEYDKEVSQLREQFTKAVEERAREIINGKKGPSIPDSINNYAATRIAKPAYHWQTRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQT3</accession>
    <name>Q6FQT3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-dehydropantoate 2-reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I03740g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447411.1">
        <property type="nucleotide sequence ID" value="XM_447411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQT3"/>
    <dbReference type="FunCoup" id="Q6FQT3">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQT3"/>
    <dbReference type="KEGG" id="cgr:2889150"/>
    <dbReference type="CGD" id="CAL0129588">
        <property type="gene designation" value="CAGL0I03740g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03740g"/>
    <dbReference type="eggNOG" id="ENOG502QWBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FQT3"/>
    <dbReference type="OMA" id="MCAITQL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF30">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="2">
        <location>
            <begin position="207"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="38681" checksum="36C35CCC342A5C4C" modified="2004-07-19" version="1">MSVNVVVVGAGGVGVVSALSLFHAGKSEVSLVVRSDYSAVVERGYRIDSCDYGQLDGWRPHHVYKDVHEAAASGTFFDYVVVTTKNIPDGPNSSTMPVLVEPFLLGNAKVDPERLTSVLLIQNGIDIEKHLVSTLKPEDYNNYVVLSGVEIVGTTKVGKAQIKHIGQDHLSVGAFDPSNPAAVESAKRFTKIYDAGDKNFVEFDERVRYSRWKKLLYNAAINTTTAIVGLDVPRTLAYGHDDSTRNALFLPAMRDIVNIAASEGIVIEEKFIDFFLNISAKHMFTPSMCVDVQKGQLMELEVILGNPLRVAEANGVEAPTLTFLYNLLSIIQGKLKEQNGLVEFDETTCSIKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQU5</accession>
    <name>DHH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DHH1</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DHH1</name>
        <name type="ordered locus">CAGL0I03476g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <text evidence="1">Is concentrated in several cytoplasmic foci called P bodies (or cytoplasmic processing bodies) which represent sites of mRNA decapping and 5' to 3' exonucleotidic decay.</text>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447399.1">
        <property type="nucleotide sequence ID" value="XM_447399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQU5"/>
    <dbReference type="SMR" id="Q6FQU5"/>
    <dbReference type="FunCoup" id="Q6FQU5">
        <property type="interactions" value="1448"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQU5"/>
    <dbReference type="EnsemblFungi" id="CAGL0I03476g-T">
        <property type="protein sequence ID" value="CAGL0I03476g-T-p1"/>
        <property type="gene ID" value="CAGL0I03476g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889178"/>
    <dbReference type="KEGG" id="cgr:2889178"/>
    <dbReference type="CGD" id="CAL0129533">
        <property type="gene designation" value="CAGL0I03476g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03476g"/>
    <dbReference type="eggNOG" id="KOG0326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_30_2_1"/>
    <dbReference type="InParanoid" id="Q6FQU5"/>
    <dbReference type="OMA" id="TYEDRHT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098562">
        <property type="term" value="C:cytoplasmic side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036267">
        <property type="term" value="P:invasive filamentous growth"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:mRNA transport"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010603">
        <property type="term" value="P:regulation of cytoplasmic mRNA processing body assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000749">
        <property type="term" value="P:response to pheromone triggering conjugation with cellular fusion"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000232187" description="ATP-dependent RNA helicase DHH1">
        <location>
            <begin position="1"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="62"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="242"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="180"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="75"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="507" mass="57695" checksum="D1257FDD0172BFB1" modified="2004-07-19" version="1">MSEDNSWKTQLNLPKKDTRPQTDDVLNTKGNSFEDFYLKRELLMGIFEAGFEKPSPIQEEAIPVAITGRDILARAKNGTGKTAAFVIPTLEKIKPKLNKIQALIMVPTRELALQTSQVIRTLGRHCGVSCMVTTGGTNLRDDILRLNETVHVLVGTPGRVLDLASRKVADLSECSLFVMDEADKMLSRDFKTIIEQVLTFLPKAHQSLLFSATFPLTVKEFMVKHLHKPYEINLMEELTLKGITQYYAFVEERQKLHCLNTLFSKLQINQAIIFCNSTNRVELLAKKITDLGYSCYYSHARMKQQDRNKVFHDFRQGKVRTLVCSDLLTRGIDIQAVNVVINFDFPKTAETYLHRIGRSGRFGHLGLAINLINWNDRFNLYKIEQELGTEIAAIPATIDKSLYVAEDDTAVPVPVPIEDPHIVHQRRMQEQQQQQQQQQGQQGQQQGYPGQQAFIPPQQGQPQFMPVPQQYMQMNQQQGMPPNQQQPPAMGYPPQQLPTGYVAQQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQW1</accession>
    <name>Q6FQW1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0I03036g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQW1"/>
    <dbReference type="FunCoup" id="Q6FQW1">
        <property type="interactions" value="656"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQW1"/>
    <dbReference type="KEGG" id="cgr:2889162"/>
    <dbReference type="CGD" id="CAL0132696">
        <property type="gene designation" value="CAGL0I03036g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03036g"/>
    <dbReference type="eggNOG" id="KOG0846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FQW1"/>
    <dbReference type="OMA" id="EPGWLVN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000017">
        <property type="entry name" value="Mrpl10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="94"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0132696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="278" mass="31154" checksum="4EC97E6FF4D05083" modified="2004-07-19" version="1">MMLRFLGSLRNGFVTSRRYVSIMGQLHPAEGAKQSYKRLGRGPSSGKGKTSGRGQKGQKARGKVKSWFEGGQTPIYKLFPKIGFTNVNARPLKVLNLQRIQEFYDAGRLKLGEGEVLDMKKMKDVGLVTGPIRDGIKILAKGQFVYNLPYKVEASRASSKAVKAIESAGGSFVARYFSRMGLRAHLVPNWFLEKRGRLPLPARPVKRKDIDYYSKEENRGYLVVENDPYLKMIQESKAQGRNKIRSAKTKKSALDIQLEALQENFIPPSSKSKTVGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQZ5</accession>
    <name>Q6FQZ5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0I02244g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447349.1">
        <property type="nucleotide sequence ID" value="XM_447349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQZ5"/>
    <dbReference type="KEGG" id="cgr:2888987"/>
    <dbReference type="CGD" id="CAL0132342">
        <property type="gene designation" value="CAGL0I02244g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02244g"/>
    <dbReference type="HOGENOM" id="CLU_1578314_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQZ5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="169" mass="19266" checksum="ADD77A2799FD9864" modified="2004-07-19" version="1">MIDDAGGEPLHSLECHQEAYENDELTETVDSEVALRSELHNAVLLLVRLGYSFASIVEKCYVKKSFLLQVFAELGLQVPTEEEYNKITECNESSLTNVHGLMKDDEQDQAKLPNSNLTDKLVRSIQHDIEELERNYLAAAVDEQTKKKLLDLRSFINSRLDNIIESFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR09</accession>
    <name>Q6FR09_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0I01936g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR09"/>
    <dbReference type="KEGG" id="cgr:2888948"/>
    <dbReference type="CGD" id="CAL0132130">
        <property type="gene designation" value="CAGL0I01936g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01936g"/>
    <dbReference type="HOGENOM" id="CLU_1447484_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR09"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000217">
        <property type="term" value="F:DNA secondary structure binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010520">
        <property type="term" value="P:regulation of reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007130">
        <property type="term" value="P:synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048323">
        <property type="entry name" value="Spo16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043637">
        <property type="entry name" value="Spo16_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21698">
        <property type="entry name" value="Spo16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19225">
        <property type="entry name" value="Spo16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spo16 protein N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Spo16 protein C-terminal" evidence="3">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0132130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="187" mass="21917" checksum="62F6EC7177EF85E6" modified="2004-07-19" version="1">MEVSFVNHIPDDGNILIVECTCQEFPKGYPDEELKMMAKKELKKLLDKIRMQDLSLLQKDDTLLIICFDSTDITIEGWEVIVEELKEKSTLWCHREIFICSKSETTKSLTMRKFIENNPIYTSFKHNLKNARPFEYDDDVKDFMVKKILSELYVSHKLTEDQLEDLLAKCNNLEEVFQELGRVPSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR59</accession>
    <name>Q6FR59_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Outer spore wall protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0I00726g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in spore wall assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OSW5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447285.1">
        <property type="nucleotide sequence ID" value="XM_447285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR59"/>
    <dbReference type="KEGG" id="cgr:2889330"/>
    <dbReference type="CGD" id="CAL0132392">
        <property type="gene designation" value="CAGL0I00726g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00726g"/>
    <dbReference type="HOGENOM" id="CLU_1948558_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR59"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031430">
        <property type="entry name" value="Osw5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17062">
        <property type="entry name" value="Osw5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0749">Sporulation</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0132392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="129" mass="14028" checksum="D4419CAB034746E0" modified="2004-07-19" version="1">MQGRLIVPLVASLVVVPLLVGATWFALCVVVCGAVSDALYRAASYLYLKSDTFMDNKYTTDDPQAHALAVAKPSPRARNKKFDLRVLQPASSPQVSPVLSSIHSMHSMHSKTDTNSHTYNIARSLETGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR92</accession>
    <name>Q6FR92_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0H10450g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG60185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447252.1">
        <property type="nucleotide sequence ID" value="XM_447252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR92"/>
    <dbReference type="FunCoup" id="Q6FR92">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR92"/>
    <dbReference type="KEGG" id="cgr:2888466"/>
    <dbReference type="CGD" id="CAL0131480">
        <property type="gene designation" value="CAGL0H10450g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10450g"/>
    <dbReference type="eggNOG" id="KOG1201">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_5_1_1"/>
    <dbReference type="InParanoid" id="Q6FR92"/>
    <dbReference type="OMA" id="IFWAKFR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0131480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34959" checksum="87FB79CF4EFD07FA" modified="2004-07-19" version="1">MDITEDIGRLWRANMHRILDIKSRILAKKKPTTNLDYDTYKEKTLVALITGGSGGLGLEIAIALVQRYKSVIVAIVDVVPPKKQLVKQYPNIIHYRCDITDSFQVAHMKKKVLLDFGKVNILVNNAAITIIKQLTDMTEAEIQRVINVNLIASYHLVSMFVPEMLYTKNGCIINIASVLGELTPSRLIVYGATKGGLIELHNYLNQQINAHNSYAYNRRGLKAILVCPGKISTTMFKDVDTPSKFLAPDLPPNELATEIIKTVDSKISSTLRRPYYSGLIPYIKILNQSYLDLLKNLSGMNRVTKLKKKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRA3</accession>
    <name>Q6FRA3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0H10208g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRA3"/>
    <dbReference type="FunCoup" id="Q6FRA3">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRA3"/>
    <dbReference type="KEGG" id="cgr:2888744"/>
    <dbReference type="CGD" id="CAL0131706">
        <property type="gene designation" value="CAGL0H10208g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10208g"/>
    <dbReference type="eggNOG" id="KOG1989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005611_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRA3"/>
    <dbReference type="OMA" id="PFEMTGQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF65">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE AKL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="507"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="509"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="775"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="917"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="940"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="967"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0131706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1027" mass="115904" checksum="B31B707D83C05627" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRC8</accession>
    <name>Q6FRC8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cold shock-induced protein TIR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIR4</name>
        <name evidence="5 6" type="ordered locus">CAGL0H09614g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447216.1">
        <property type="nucleotide sequence ID" value="XM_447216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRC8"/>
    <dbReference type="FunCoup" id="Q6FRC8">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRC8"/>
    <dbReference type="KEGG" id="cgr:2888738"/>
    <dbReference type="CGD" id="CAL0131934">
        <property type="gene designation" value="TIR4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09614g"/>
    <dbReference type="eggNOG" id="ENOG502RYU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071083_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRC8"/>
    <dbReference type="OMA" id="ISALPWY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000992">
        <property type="entry name" value="SRP1_TIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000420">
        <property type="entry name" value="Yeast_PIR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00399">
        <property type="entry name" value="PIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00660">
        <property type="entry name" value="SRP1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50256">
        <property type="entry name" value="PIR_REPEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273513" description="Cold shock-induced protein TIR1" evidence="4">
        <location>
            <begin position="20"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="115"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="22934" checksum="47CE286F575C85BE" modified="2004-07-19" version="1">MAYSKTAILIAAAAALVSAQTPQQLDELNVILDDVKSNLSSYMSLVQDPSSGITLANLPAGVLNLGMALASATDDSYTTLYKDIDFDGIVPFLSKLPWYSERLAGKLAKDLGEASSSAAPSSSAAPSSSAAPTTSSSAAPTTSSSAAPSSSKASSSAAPSSSKASSSAAPSSSKAASSSAKASSSAKASTTVVTSATKAAISQIGDGQIQAQTANGAGKVAAGMGAGVFAAAALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRF9</accession>
    <name>Q6FRF9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0H08888g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447185.1">
        <property type="nucleotide sequence ID" value="XM_447185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRF9"/>
    <dbReference type="STRING" id="284593.Q6FRF9"/>
    <dbReference type="KEGG" id="cgr:2888799"/>
    <dbReference type="CGD" id="CAL0129760">
        <property type="gene designation" value="CAGL0H08888g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08888g"/>
    <dbReference type="eggNOG" id="ENOG502QSVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010226_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRF9"/>
    <dbReference type="OMA" id="FKVFQRA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF4">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273493" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="543"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="589"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="673"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="718"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0129760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="806" mass="92103" checksum="5AE64460E97F1806" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRK4</accession>
    <name>Q6FRK4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0H07865g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the MSS1-MTO1 complex that catalyzes the 5-carboxymethylaminomethyluridine (cmnm(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRK4"/>
    <dbReference type="FunCoup" id="Q6FRK4">
        <property type="interactions" value="813"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRK4"/>
    <dbReference type="KEGG" id="cgr:2888796"/>
    <dbReference type="CGD" id="CAL0130283">
        <property type="gene designation" value="CAGL0H07865g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07865g"/>
    <dbReference type="eggNOG" id="KOG2311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FRK4"/>
    <dbReference type="OMA" id="CNPAMGG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000145">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.570:FF:000001">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000002">
        <property type="entry name" value="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="entry name" value="GidA associated domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049312">
        <property type="entry name" value="GIDA_C_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047001">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00136">
        <property type="entry name" value="mnmG_gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="GLUCOSE INHIBITED DIVISION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21680">
        <property type="entry name" value="GIDA_C_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="SAM_GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM01228">
        <property type="entry name" value="GIDA_assoc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme C-terminal subdomain" evidence="7">
        <location>
            <begin position="580"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0130283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="663" mass="74367" checksum="E740237DDA1CE684" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRK6</accession>
    <name>Q6FRK6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0H07821g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRK6"/>
    <dbReference type="FunCoup" id="Q6FRK6">
        <property type="interactions" value="1255"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRK6"/>
    <dbReference type="KEGG" id="cgr:2888710"/>
    <dbReference type="CGD" id="CAL0131908">
        <property type="gene designation" value="CAGL0H07821g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07821g"/>
    <dbReference type="eggNOG" id="KOG1992">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009614_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRK6"/>
    <dbReference type="OMA" id="AENEFLM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="23"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0131908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="961" mass="109500" checksum="2C9A6A2996A3E128" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRL1</accession>
    <name>Q6FRL1_CANGA</name>
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        <recommendedName>
            <fullName evidence="6">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="primary">RTF1</name>
        <name evidence="7 8" type="ordered locus">CAGL0H07711g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_447133.1"/>
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    </dbReference>
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    <dbReference type="CGD" id="CAL0129872">
        <property type="gene designation" value="RTF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07711g"/>
    <dbReference type="eggNOG" id="KOG2402">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
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        <property type="term" value="C:Cdc73/Paf1 complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:euchromatin"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001015">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Related to Pol II transcription elongation factor"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
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        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="238"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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        </location>
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        <location>
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    </feature>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRU2</accession>
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            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
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                <person name="Ferry-Dumazet H."/>
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                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
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                <person name="Scarpelli C."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D"/>
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        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15032:SF4">
        <property type="entry name" value="N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038896">
        <property type="entry name" value="NAPE-PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="204"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="446" mass="51873" checksum="18561B349890685D" modified="2004-07-19" version="1">MFCSVGRIPFQRCRLHARSLSISPLTKKEKRRIGYGSLAVLSFLVPYTAYAVFVTVSAYSEIDTRLDLSEVVEKKDGLNYQGTLIKYSPLQVLGRYENPFAEYRIQTIYEFFINRVVELFQRNRGGIPAERAHMNQLMPVHKPTWSEDKIKIEDEQLIKYQLLTEHDDLKTMNVNVDSKDDNIPVYSTWLGQSCNFVSYNGLKVLTDPLFSDYLIHKKLGPKRITDMPANIEDVPKPDIIMVSHNHPDHLDQESIEHWKNSETLWIVPKGLKSYMDKNKIKNYIELSWWETCELEKDNEIYHISCTPAMHWSGRSVLDTNQSLWCSFLLSHNKKPILFHAGDTGYVKDLYVRIKDRFGAGCKLALLPCGQYCPEWHQKPRHINPREVIKIMKDMEANQVLGVHWGTFVLSGEYFLEPKERLEMLAEFDGIRDKCYCPELGKTIKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSP9</accession>
    <name>Q6FSP9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MMS19 nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0G08800g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MET18/MMS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSP9"/>
    <dbReference type="FunCoup" id="Q6FSP9">
        <property type="interactions" value="1031"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSP9"/>
    <dbReference type="KEGG" id="cgr:2888095"/>
    <dbReference type="CGD" id="CAL0130628">
        <property type="gene designation" value="CAGL0G08800g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08800g"/>
    <dbReference type="eggNOG" id="KOG1967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005943_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FSP9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039920">
        <property type="entry name" value="MMS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024687">
        <property type="entry name" value="MMS19_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891">
        <property type="entry name" value="DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12891:SF0">
        <property type="entry name" value="MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12460">
        <property type="entry name" value="MMS19_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="7">
        <location>
            <begin position="42"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="MMS19 C-terminal" evidence="6">
        <location>
            <begin position="569"/>
            <end position="970"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0130628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1020" mass="116095" checksum="B85891DB63BC74C7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSV5</accession>
    <name>Q6FSV5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0G07535g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSV5"/>
    <dbReference type="FunCoup" id="Q6FSV5">
        <property type="interactions" value="665"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSV5"/>
    <dbReference type="KEGG" id="cgr:2888429"/>
    <dbReference type="CGD" id="CAL0130446">
        <property type="gene designation" value="CAGL0G07535g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07535g"/>
    <dbReference type="eggNOG" id="KOG1765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065163_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FSV5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0130446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="203" mass="22914" checksum="ECE9A3B13A8B95F2" modified="2004-07-19" version="1">MSEYKNLPVTVEKPIPVTYDLGNLSVFDTNVIDRNDVDSSNAKREEVIKSVTRDNVQLLINQLLSLPIKKTTEHTGGNSGQGATVALLQLPEPSSELPREKPLPKPKALTKWQKFAAKKGIKPKERAGKMVFDEATGKWAPKWGYNGINKKLDDQWLVEVDDDTKGTENELIDPRSLNRAERKRLVKKNERQQKKNLKNAMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSY0</accession>
    <name>Q6FSY0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0G06974g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSY0"/>
    <dbReference type="FunCoup" id="Q6FSY0">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSY0"/>
    <dbReference type="KEGG" id="cgr:2888087"/>
    <dbReference type="CGD" id="CAL0130620">
        <property type="gene designation" value="CAGL0G06974g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06974g"/>
    <dbReference type="eggNOG" id="KOG4168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092529_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FSY0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0130620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="153" mass="18430" checksum="3E0713C16A54D036" modified="2004-07-19" version="1">MKVLETRDAFLSDYEVLQHLSKMERQYHWDDESIAEMSTKKRHMHRKRPYNNPALQRITRDVIDYLKMNKYDVAQEEEEDVKKMSPLCNLNDDKFTELVMRLNQYELFQAEKLQIVNQLPVQMVHLYAIVEECDTRFTQEQIDALLQLVAEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT34</accession>
    <name>Q6FT34_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0G05720g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT34"/>
    <dbReference type="STRING" id="284593.Q6FT34"/>
    <dbReference type="KEGG" id="cgr:2888257"/>
    <dbReference type="CGD" id="CAL0130219">
        <property type="gene designation" value="CAGL0G05720g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05720g"/>
    <dbReference type="eggNOG" id="KOG0590">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_375971_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT34"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF113">
        <property type="entry name" value="NITROGEN PERMEASE REACTIVATOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="316"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0130219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="738" mass="84448" checksum="4B3E3D1C0CF4D470" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTS0</accession>
    <name>Q6FTS0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="11">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Exo-1,3-beta-glucanase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0G00220g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="11"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTS0"/>
    <dbReference type="FunCoup" id="Q6FTS0">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTS0"/>
    <dbReference type="KEGG" id="cgr:2888394"/>
    <dbReference type="CGD" id="CAL0129730">
        <property type="gene designation" value="CAGL0G00220g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00220g"/>
    <dbReference type="eggNOG" id="ENOG502QQE6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028820_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FTS0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000105">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF26">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273519" description="glucan 1,3-beta-glucosidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0129730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG59301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="308" mass="33688" checksum="734DBD5FF6374C5E" modified="2004-07-19" version="1">MRFSTVAALAFGASQVAAIGELAFNLGVKNNDGTCKTTNDYENDLKVLKSYTSTVKVYAASDCNTLENLGPAAEAEGFNIFLGIWPNDEAHFQAEKNALSSFLPNLKSSTIAGFLVGSEALYRDDLTASQLADKINDIRNYVSNIKDSQGNSYSGKQVGTVDSWNVLVAGYNAPVITASDFVMANAFSYWQGQTMQNASYSFFDDIMQALQTIQGVKGSTDITFWVGETGWPTDGTNFEASYPSVDNAKQFWKEGICAMRAWGVNVIVFEAFDEDWKPNTSGTSDVEKHWGVWTSGDNLKYSLDCSFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU53</accession>
    <name>Q6FU53_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0F06259g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446241.1">
        <property type="nucleotide sequence ID" value="XM_446241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU53"/>
    <dbReference type="STRING" id="284593.Q6FU53"/>
    <dbReference type="KEGG" id="cgr:2887755"/>
    <dbReference type="CGD" id="CAL0131420">
        <property type="gene designation" value="CAGL0F06259g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06259g"/>
    <dbReference type="eggNOG" id="KOG0015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1377947_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU53"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900079">
        <property type="term" value="P:regulation of arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900081">
        <property type="term" value="P:regulation of arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="114"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0131420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="198" mass="22004" checksum="0F08FD729D89BDFC" modified="2004-07-19" version="1">MNSQSLFGISPISSSDHINLDPDLGKMPGMPGMPGIQGQRQDQRPQRQVQMPAHMPGQRPTVGGGDEVRGTRDYSDKGNGNGNEHEIENEQENENENENDDEDEEVSTPSSAVGKRRKAPLKYIENTTRRHVTFAKRRHGIMKKAYELAVMTGANVLLLILSPKGLVYTFATPSLQPLIRDDPGKELIRRCLNQDNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU89</accession>
    <name>Q6FU89_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0F05401g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a zinc transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU89"/>
    <dbReference type="FunCoup" id="Q6FU89">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU89"/>
    <dbReference type="KEGG" id="cgr:2887892"/>
    <dbReference type="CGD" id="CAL0131100">
        <property type="gene designation" value="CAGL0F05401g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05401g"/>
    <dbReference type="eggNOG" id="KOG1484">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_11_1_1"/>
    <dbReference type="InParanoid" id="Q6FU89"/>
    <dbReference type="OMA" id="RIFNPIH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000014">
        <property type="entry name" value="Cation efflux protein/ zinc transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="602"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="640"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="668"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="499"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="733"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="750"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0131100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="851" mass="95616" checksum="3E0331F6203B0C06" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU91</accession>
    <name>Q6FU91_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ZCF11</name>
        <name evidence="3 4" type="ordered locus">CAGL0F05357g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
            <begin position="448"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
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        <location>
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</entry>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG59073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUT8</accession>
    <name>Q6FUT8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0F00737g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
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                <person name="Fabre E."/>
                <person name="Fairhead C."/>
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                <person name="Hantraye F."/>
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                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
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                <person name="Wesolowski-Louvel M."/>
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                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="34"/>
    </dbReference>
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    <dbReference type="KEGG" id="cgr:2887836"/>
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        <property type="gene designation" value="CAGL0F00737g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00737g"/>
    <dbReference type="eggNOG" id="ENOG502QS9U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012509_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUT8"/>
    <dbReference type="OMA" id="LRMQFKL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002092">
        <property type="term" value="P:positive regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="127"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="626"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="795" mass="87793" checksum="C78C36ADDDD7C6CE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUU7</accession>
    <name>Q6FUU7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0F00539g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUU7"/>
    <dbReference type="FunCoup" id="Q6FUU7">
        <property type="interactions" value="1431"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUU7"/>
    <dbReference type="KEGG" id="cgr:2887927"/>
    <dbReference type="CGD" id="CAL0131174">
        <property type="gene designation" value="CAGL0F00539g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00539g"/>
    <dbReference type="eggNOG" id="KOG0357">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_7_2_1"/>
    <dbReference type="InParanoid" id="Q6FUU7"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0131174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="565" mass="62569" checksum="A51D91DC1D9569F2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVA5</accession>
    <name>Q6FVA5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAGL0E03498g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVA5"/>
    <dbReference type="KEGG" id="cgr:2887498"/>
    <dbReference type="HOGENOM" id="CLU_1643462_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVA5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="161" mass="17909" checksum="415CE09C9D810CD3" modified="2004-07-19" version="1">MQDIREEMDDTVVIGDEDVLSTSSGSSVEVVEAPASSERPVLTPQIVALWATMMAVVLTVSVWYMQRYGYISTLTPIGGESVYVFKSAGGDSIKVVAPRGMQGQYMLDFDQGTMRRVLGDHTLVRSFYDVAERVRPRFKSGVSATRSLLKRYRDMLSQRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVA7</accession>
    <name>Q6FVA7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IMH1</name>
        <name evidence="9 10" type="ordered locus">CAGL0E03454g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445837.1">
        <property type="nucleotide sequence ID" value="XM_445837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVA7"/>
    <dbReference type="FunCoup" id="Q6FVA7">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVA7"/>
    <dbReference type="GeneID" id="2887506"/>
    <dbReference type="KEGG" id="cgr:2887506"/>
    <dbReference type="CGD" id="CAL0128856">
        <property type="gene designation" value="IMH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E03454g"/>
    <dbReference type="eggNOG" id="ENOG502S0A5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006987_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVA7"/>
    <dbReference type="OMA" id="NIGQDHV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051952">
        <property type="entry name" value="Golgi-autophagy_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23157:SF25">
        <property type="entry name" value="GRIP AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="8">
        <location>
            <begin position="817"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="775"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="104"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0128856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="867" mass="99087" checksum="AE8691E3BC02CD7D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVB1</accession>
    <name>Q6FVB1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0E03311g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVB1"/>
    <dbReference type="FunCoup" id="Q6FVB1">
        <property type="interactions" value="631"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVB1"/>
    <dbReference type="KEGG" id="cgr:2887285"/>
    <dbReference type="CGD" id="CAL0128586">
        <property type="gene designation" value="CAGL0E03311g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E03311g"/>
    <dbReference type="eggNOG" id="KOG3887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047421_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FVB1"/>
    <dbReference type="OMA" id="NCRTFQE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000008">
        <property type="entry name" value="GTP-binding protein GTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001086">
        <property type="entry name" value="GTP-binding protein GTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0128586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="339" mass="38234" checksum="913CE9FD31FA76BD" modified="2004-07-19" version="1">MSLENTDSKAMVLLMGLRRCGKSSICKVVFHNMQPLDTLYLESTSNPTMEHFSTLIDLAVMELPGQLNYFEPNYDSAELFKSVGALVYVIDSQDEYMNAVTNLAMIIEYAYKVNPSINIEVLIHKVDGLSEDFKVDAQRDIMQRTGEELLELGLDGVQVSFYLTSIFDHSIYEAFSRIVQKLIPELSFLENMLDNLIQHSKIEKAFLFDINSKIYVSTDSNPVDIQTYEVCAEFVDVTIDLFDLYKATQNLISDGNEQPKKRELKNVSQLANGVVIYLRQMIRGLALVALIRPNDTDTENCLTVVDYNIDVFKKGLEKIWANSTTDAAKVAAIDNGDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVK5</accession>
    <name>Q6FVK5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CPR1</name>
        <name evidence="9 10" type="ordered locus">CAGL0E01177g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445739.1">
        <property type="nucleotide sequence ID" value="XM_445739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVK5"/>
    <dbReference type="FunCoup" id="Q6FVK5">
        <property type="interactions" value="706"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVK5"/>
    <dbReference type="GeneID" id="2887331"/>
    <dbReference type="KEGG" id="cgr:2887331"/>
    <dbReference type="CGD" id="CAL0128726">
        <property type="gene designation" value="CPR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01177g"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_3_1"/>
    <dbReference type="InParanoid" id="Q6FVK5"/>
    <dbReference type="OMA" id="FKSIVPR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030437">
        <property type="term" value="P:ascospore formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045835">
        <property type="term" value="P:negative regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045836">
        <property type="term" value="P:positive regulation of meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0128726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="162" mass="17392" checksum="7D2EDAA156B2EBA9" modified="2004-07-19" version="1">MSKVYFDIEADGQPLGRVVFQLYDDVVPKTAANFRALCTGEKGFGYAGSPFHRVIPDFMLQGGDFTAGNGTGGKSIYGGKFPDENFVKRHERPGLLSMANAGPNTNGSQFFITTVPCPWLDGKHVVFGEVSEGYDVVKKVESMGSSSGATRARIIVSKSGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVY6</accession>
    <name>Q6FVY6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rad61 Wapl domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0D04444g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVY6"/>
    <dbReference type="FunCoup" id="Q6FVY6">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887253"/>
    <dbReference type="CGD" id="CAL0128049">
        <property type="gene designation" value="CAGL0D04444g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D04444g"/>
    <dbReference type="HOGENOM" id="CLU_474855_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVY6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="65201" checksum="2A81D866E857B850" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW74</accession>
    <name>Q6FW74_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0D02420g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW74"/>
    <dbReference type="FunCoup" id="Q6FW74">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW74"/>
    <dbReference type="KEGG" id="cgr:2887264"/>
    <dbReference type="CGD" id="CAL0128515">
        <property type="gene designation" value="CAGL0D02420g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02420g"/>
    <dbReference type="eggNOG" id="ENOG502S6GM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109465_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW74"/>
    <dbReference type="OMA" id="YVTKFHP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032509">
        <property type="term" value="P:endosome transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017435">
        <property type="entry name" value="ESCRT-1_cplx_Vps37_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038214">
        <property type="entry name" value="ESCRT1_Vps37_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="8">
        <location>
            <begin position="104"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0128515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="185" mass="21744" checksum="12DF9714A6541791" modified="2004-07-19" version="1">MDKPPILPPREDAVALEPANDQPKLDVKLPVNINLLSYNELLELINQHRDKLHWFCASMDSFEPITEEVKRLKNQFKELEEKFSKLEDGKVVIQDQIAELVILESEYTKKYQNLQQLIRSNYSKDVAKRTMLNKIKENEQKCDELEINAKGSLDLDVFLKSYMDFKLDYHMQKQKLNVLSAQNNF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWD4</accession>
    <name>MCH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Probable transporter MCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MCH1</name>
        <name type="ordered locus">CAGL0D01056g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445460.1">
        <property type="nucleotide sequence ID" value="XM_445460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWD4"/>
    <dbReference type="FunCoup" id="Q6FWD4">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q6FWD4">
        <property type="glycosylation" value="2 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0D01056g-T">
        <property type="protein sequence ID" value="CAGL0D01056g-T-p1"/>
        <property type="gene ID" value="CAGL0D01056g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887171"/>
    <dbReference type="KEGG" id="cgr:2887171"/>
    <dbReference type="CGD" id="CAL0128363">
        <property type="gene designation" value="CAGL0D01056g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01056g"/>
    <dbReference type="eggNOG" id="ENOG502QTNE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012596_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FWD4"/>
    <dbReference type="OMA" id="PTMWWLA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17354">
        <property type="entry name" value="MFS_Mch1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF45">
        <property type="entry name" value="TRANSPORTER MCH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000084869" description="Probable transporter MCH1">
        <location>
            <begin position="1"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="489" mass="54363" checksum="0831C3709803E924" modified="2004-07-19" version="1">MALSSIEHYLSYHLRVLLPQVLSSKSSHNIAYIFALFAAITSGFVSLISLYAQPWQEHLSYSSWQINMIVTVINMGMYLTPPILGIIADIHGPITLSLSSVLGFIPSYAYLAYTFHRDHSFTNESDGSFTPTLVCFFIIGVATSGLYFSALITCAKLFPGTKLLSISIPTTCYGLSSLIGSQFLRVKYFHPVDYPYLDLGRVFKAFAWIYTVIGVMIWIATSKVAQIQHEADIMEEQDRMAEPSDNDVENHYDDNEQSRLLHATHAQQMTLMKVFRDPVLYIFGATIFCALGPLEMFIANMGSLTNVLAGGHEPAMSSALLSIYALTSTLTRLGTGLTVDYFNKRQLSVKWILLLFLVVGLVTQGKIYMLSMSSLDHSHMVTINRKLFYIGIMQGIAYGGLFTIYPTITLMVWGEKMFGTAYGTLMIAPALGSALSCLIYADVYDSECANSTTRSCIAPVYETTALEFCAAILLTVVVTVLWRKRRTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWE4</accession>
    <name>Q6FWE4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0D00836g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWE4"/>
    <dbReference type="FunCoup" id="Q6FWE4">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWE4"/>
    <dbReference type="KEGG" id="cgr:2887166"/>
    <dbReference type="CGD" id="CAL0128303">
        <property type="gene designation" value="CAGL0D00836g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00836g"/>
    <dbReference type="eggNOG" id="ENOG502RYAI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446315_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWE4"/>
    <dbReference type="OMA" id="ADMDMVT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd13394">
        <property type="entry name" value="Syo1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="430"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0128303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="619" mass="70222" checksum="9F39CA5018C58DAB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWF0</accession>
    <name>Q6FWF0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0D00704g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWF0"/>
    <dbReference type="FunCoup" id="Q6FWF0">
        <property type="interactions" value="693"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWF0"/>
    <dbReference type="KEGG" id="cgr:2887172"/>
    <dbReference type="CGD" id="CAL0128267">
        <property type="gene designation" value="CAGL0D00704g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00704g"/>
    <dbReference type="eggNOG" id="KOG1962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087648_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FWF0"/>
    <dbReference type="OMA" id="EMGLFML"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="7">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0128267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="191" mass="21697" checksum="D568AD912169D7E7" modified="2004-07-19" version="1">MSLYYALVFGILVLEIAVFSVLSLPLPTRIRRPMMLVLLKPFRAPTVQVGIKCILGFILILFIDCITKVYNINRELNAGSKGQSNTAGATGGTVFAQDRIEVVSRKFLAQRNMYLTGITLFLTFVVVRTYALVSELFQLKDNYRAAEGEDTKGMTPEEAEKRRKELLEEIDRKEKEINRLTEKATLLQKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWH8</accession>
    <name>Q6FWH8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine deaminase</fullName>
            <shortName evidence="8">Guanase</shortName>
            <ecNumber evidence="8">3.5.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Guanine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0C05555g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>guanine + H2O + H(+) = xanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14665"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; guanine degradation; xanthine from guanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.3" evidence="8"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWH8"/>
    <dbReference type="FunCoup" id="Q6FWH8">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWH8"/>
    <dbReference type="KEGG" id="cgr:2886875"/>
    <dbReference type="CGD" id="CAL0127312">
        <property type="gene designation" value="CAGL0C05555g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05555g"/>
    <dbReference type="eggNOG" id="KOG3968">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FWH8"/>
    <dbReference type="OMA" id="CVHMNDS"/>
    <dbReference type="UniPathway" id="UPA00603">
        <property type="reaction ID" value="UER00660"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000022">
        <property type="entry name" value="Guanine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014311">
        <property type="entry name" value="Guanine_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02967">
        <property type="entry name" value="guan_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="87"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0127312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="483" mass="53665" checksum="2694413DBD878318" modified="2004-07-19" version="1">MVSLREQLYRLVAFHGTFIDTPVLGQLRVREECTVVVHMTDDGCGTIVLIRDHCEPMDAVREYDPTVHESDVKIVAATDGSGSQFFFPGFIDTHIHASQYPNCGLFGKSTLLDWLETYTFPLEASLADLDIASDVYTSVIKRTLSAGTTTATYYTTIDTESSKLMGTLCSKLGQRALIGKVCMDQNAPDYYIEDAKDSIESCKEMISFFKNDLNDPRVNAIITPRFAPSCSKDLLAALGALAKENELHIQTHLSENNKEISWVKSLFPECKSYTDVYYQHGLLGERTVLAHCIHCSEDEADLIKKTNSGVSHCPVSNSALASGECRVKWWLQKGVSVGLGTDVSGGYSADILLSARHAHLVSRHLAMKTDEEKEKINVMLSVNECLYLATMGGAGVLHMQDQIGSFDVGKQFDTQLISLDVPNSNVQLFYWQKLNGTKAIKGIRNQPPLLNHEDIIAKWFFNGDDRNVKYTWVSGQLVHSKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWJ6</accession>
    <name>Q6FWJ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein MAM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HLP</name>
        <name evidence="12 13" type="ordered locus">CAGL0C05159g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWJ6"/>
    <dbReference type="FunCoup" id="Q6FWJ6">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWJ6"/>
    <dbReference type="KEGG" id="cgr:2886790"/>
    <dbReference type="CGD" id="CAL0127240">
        <property type="gene designation" value="HLP"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05159g"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011310_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FWJ6"/>
    <dbReference type="OMA" id="DIHQHIM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044650">
        <property type="term" value="P:adhesion of symbiont to host cell"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="38"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="302"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="602"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="621"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0127240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="70543" checksum="8911E6D09AFD499E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWY0</accession>
    <name>Q6FWY0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0C02035g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWY0"/>
    <dbReference type="FunCoup" id="Q6FWY0">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWY0"/>
    <dbReference type="MEROPS" id="M20.017"/>
    <dbReference type="KEGG" id="cgr:2886847"/>
    <dbReference type="CGD" id="CAL0127300">
        <property type="gene designation" value="CAGL0C02035g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02035g"/>
    <dbReference type="eggNOG" id="KOG2276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029469_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FWY0"/>
    <dbReference type="OMA" id="CNVKFMI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="224"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0127300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="483" mass="53282" checksum="E14F95F952ABBD97" modified="2004-07-19" version="1">MSSTRAFDKVFTKIDELKPEFIGMLSKAIAIPAVSSDESLRPRVVEKAHFLADHLKKLGFADIQLKELGTQPPPVSDPNLQLPPIVLARYGNDPAKKNVLVYGHYDVQPAKLEDGWDSEPFELVVDEKKQVLRARGSSDDTGPLTGWLHVVQAHQAAGVELPVNLITCFEGMEESGSLGLEELIGAEKDKYFKGVDAVCISDNYWLGTRKPVLTYGLRGCNYYQVTIEGPGADLHSGMFGGIIAEPMIDLVQVMSTLVDSQGKILIEGVDAMVAKETEKEQELYKTIDFSVEELNAASGSETALYTKKEDILKHRWRYPSLSIHGVEGAFYSQGAKTVIPAKVIGKFSIRTVPDIDSEKLTQIVVDHCHAAFKKLNSPNRCKAELIHDGNYWVSDPFNAQFQAAAKATKDVYGVEPDYTREGGSIPITLTFEEQLKTSVLLLPMGRGDDGAHSINEKLDISNFVNGMKLMAAYLHYYAESPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXC0</accession>
    <name>Q6FXC0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PET54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0B02123g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXC0"/>
    <dbReference type="FunCoup" id="Q6FXC0">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXC0"/>
    <dbReference type="KEGG" id="cgr:2886534"/>
    <dbReference type="CGD" id="CAL0127850">
        <property type="gene designation" value="CAGL0B02123g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B02123g"/>
    <dbReference type="eggNOG" id="ENOG502RR5W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1066355_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXC0"/>
    <dbReference type="OMA" id="KHCFKLY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000372">
        <property type="term" value="P:Group I intron splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090615">
        <property type="term" value="P:mitochondrial mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0127850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG57962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="32712" checksum="782DF3AD73147DF0" modified="2004-07-19" version="1">MTSHKQLIESVLKGVNGTNIRKVGEKLLKQEKASVVGHPGVLALAYDSYDPSLTYADFAKLVTQRQMSMTSTPQTIKFDLLKRRDPKYFTFKDQYLLLFNRNIDLRDYLNITKDSTINRVRVRWRPLVEGKDEHSSYLGERHELIYRKYCRNLEAAYLDRKQYFDVVNKEMTQETISDEPQLSCLIERIHEIEKKCAVVWNMPMESKQLEPYFSFYDIVHSFDMYWNRDLSKTFKFIRFNTQEDCKQFKKNYHGYVYDETNPDVNKILVETLNGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXL1</accession>
    <name>Q6FXL1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">IDP2</name>
        <name evidence="17 18" type="ordered locus">CAGL0B04917g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445184.1">
        <property type="nucleotide sequence ID" value="XM_445184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXL1"/>
    <dbReference type="FunCoup" id="Q6FXL1">
        <property type="interactions" value="843"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXL1"/>
    <dbReference type="GeneID" id="2886496"/>
    <dbReference type="KEGG" id="cgr:2886496"/>
    <dbReference type="CGD" id="CAL0127108">
        <property type="gene designation" value="IDP2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04917g"/>
    <dbReference type="eggNOG" id="KOG1526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FXL1"/>
    <dbReference type="OMA" id="ACVECID"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF41">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="9"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="94"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="310"/>
            <end position="315"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0127108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG58084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="411" mass="46757" checksum="692100F017064F7A" modified="2004-07-19" version="1">MSKVKVVNPIVEMDGDEQTRIIWHLIREKLILPFLDVDLKYYDLSIEYRDETNDKVTEDSALATLKYGVAVKCATITPDEARVEEFNLKEMWKSPNGTIRNILGGTVFREPIVIPRIPKLVPQWKEPIIIGRHAFGDQYRATDVVIPDEGEVRLVYKSKDGKTDIDIPVYNFPKEGGVAMMMYNTTESIRGFARASFNMALEHEMPLYSTTKNTILKKYDGKFKDTFESMYEAEYKEQFEAKGIWYEHRLIDDMVAQMLKSKGGFIIAMKNYDGDVESDIVAQGFGSLGLMTSVLISPDGKTFESEAAHGTVTRHYRQHQQGKETSTNSIASIFAWTRGIIQRGKLDETADVVKFGELLERATVDTVQEDGIMTKDLALILGKTDRSAYVTTEEFIDAVENRIKSEFQKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="143" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXP5</accession>
    <name>Q6FXP5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0B04147g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXP5"/>
    <dbReference type="FunCoup" id="Q6FXP5">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXP5"/>
    <dbReference type="KEGG" id="cgr:2886570"/>
    <dbReference type="CGD" id="CAL0127046">
        <property type="gene designation" value="CAGL0B04147g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04147g"/>
    <dbReference type="eggNOG" id="KOG0605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_67_4_1"/>
    <dbReference type="InParanoid" id="Q6FXP5"/>
    <dbReference type="OMA" id="KLRVDQF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061013">
        <property type="term" value="P:regulation of mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21776">
        <property type="entry name" value="MobB_Sid2p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="171"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="472"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0127046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="566" mass="65990" checksum="D2FDEDDC540B8C22" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXQ4</accession>
    <name>DENR_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TMA22</name>
        <name type="ordered locus">CAGL0B03927g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445141.1">
        <property type="nucleotide sequence ID" value="XM_445141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXQ4"/>
    <dbReference type="SMR" id="Q6FXQ4"/>
    <dbReference type="FunCoup" id="Q6FXQ4">
        <property type="interactions" value="1264"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXQ4"/>
    <dbReference type="EnsemblFungi" id="CAGL0B03927g-T">
        <property type="protein sequence ID" value="CAGL0B03927g-T-p1"/>
        <property type="gene ID" value="CAGL0B03927g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886519"/>
    <dbReference type="KEGG" id="cgr:2886519"/>
    <dbReference type="CGD" id="CAL0126992">
        <property type="gene designation" value="CAGL0B03927g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_B03927g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03927g"/>
    <dbReference type="eggNOG" id="KOG3239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073511_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FXQ4"/>
    <dbReference type="OMA" id="EVFEIDM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000013">
        <property type="entry name" value="Translation machinery-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000320438" description="Translation machinery-associated protein 22">
        <location>
            <begin position="1"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="SUI1" evidence="2">
        <location>
            <begin position="97"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="196" mass="22129" checksum="FE7FE77388348667" modified="2004-07-19" version="1">MLKEVVYCGVCTYPIDYCEFSGKLKRCKVWLKENHADLYDKLYSEDDAAAASLSAKLAESSIGEAREEKLEKDLQKLQTKQENKEQRELAKKLSSKVIVKREARTKRKYIVAISGLEVFEIDMKKLAKTFASKFATGCSVSKNAEKKEEVVVQGDVLDEVVAYIHSLLEEKGMKDVKVETIDTKKKKKPEATPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXR3</accession>
    <name>Q6FXR3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PST3</name>
        <name evidence="4 5" type="ordered locus">CAGL0B03685g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445132.1">
        <property type="nucleotide sequence ID" value="XM_445132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXR3"/>
    <dbReference type="FunCoup" id="Q6FXR3">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXR3"/>
    <dbReference type="KEGG" id="cgr:2886562"/>
    <dbReference type="CGD" id="CAL0127884">
        <property type="gene designation" value="PST3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03685g"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXR3"/>
    <dbReference type="OMA" id="HGMPYIP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160020">
        <property type="term" value="P:positive regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0127884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="271" mass="29747" checksum="091CE422E85D1C1B" modified="2004-07-19" version="1">MKVAIITYSTYGHIDNLARAVKKGVESAGGQADLYRVEETLSKEILAQMNAPEKASDIPVATENILTEYDAFLFGVPTRFGTLPAQWSSFWDKTGGLWAQGALNGKVGGFFVSTSSYGGGQEATVKHCLSYLAHHGIIYVPLGYKNAFAELANIEEVHGGSPWGAGTLAGADGSRTASELELRIAQIQGKTFYETAIKFAPTSSAMMDDKMMKDDKMMKDDKMMKDDKMKSGKKAAMKDDKMMKDDKMKDDKMKDDKMKEKDSKFSCCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXU6</accession>
    <name>Q6FXU6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0A00473g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXU6"/>
    <dbReference type="FunCoup" id="Q6FXU6">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXU6"/>
    <dbReference type="KEGG" id="cgr:2886492"/>
    <dbReference type="CGD" id="CAL0126703">
        <property type="gene designation" value="CAGL0A00473g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A00473g"/>
    <dbReference type="eggNOG" id="KOG2049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016143_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXU6"/>
    <dbReference type="OMA" id="FRRQTFH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="436"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="463"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="499"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="535"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="572"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="644"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="684"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="722"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0126703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG57684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="786" mass="86998" checksum="8C779745DCB49A54" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY06</accession>
    <name>Q6FY06_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0A02046g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY06"/>
    <dbReference type="FunCoup" id="Q6FY06">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY06"/>
    <dbReference type="KEGG" id="cgr:2886389"/>
    <dbReference type="CGD" id="CAL0126545">
        <property type="gene designation" value="CAGL0A02046g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02046g"/>
    <dbReference type="eggNOG" id="KOG3780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018982_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FY06"/>
    <dbReference type="OMA" id="IAVDNTW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071444">
        <property type="term" value="P:cellular response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002092">
        <property type="term" value="P:positive regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="237"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0126545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG57747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="776" mass="86211" checksum="B82DEC8C549AF3B4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY42</accession>
    <name>Q6FY42_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HXT6/7</name>
        <name evidence="12 13" type="ordered locus">CAGL0A02211g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444860.1">
        <property type="nucleotide sequence ID" value="XM_444860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY42"/>
    <dbReference type="FunCoup" id="Q6FY42">
        <property type="interactions" value="1487"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY42"/>
    <dbReference type="GeneID" id="2886382"/>
    <dbReference type="KEGG" id="cgr:2886382"/>
    <dbReference type="CGD" id="CAL0126597">
        <property type="gene designation" value="HXT6/7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02211g"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome A"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="53"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0126597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG57753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="552" mass="61546" checksum="FC64876DE6D209A5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY86</accession>
    <name>Q6FY86_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0A04191g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for protein translocation in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY86"/>
    <dbReference type="FunCoup" id="Q6FY86">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY86"/>
    <dbReference type="KEGG" id="cgr:2886397"/>
    <dbReference type="CGD" id="CAL0126923">
        <property type="gene designation" value="CAGL0A04191g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04191g"/>
    <dbReference type="eggNOG" id="KOG3457">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133423_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FY86"/>
    <dbReference type="OMA" id="FITCIMA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071261">
        <property type="term" value="C:Ssh1 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006398">
        <property type="entry name" value="Sec61_beta_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0126923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG57842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="89" mass="9607" checksum="CBD6D8D2767D5837" modified="2004-07-19" version="1">MSTPPPPGGHRTLQRRRQAQAVKEKQQTQTPTSARAAGFGGSSSSILKIFTDEADGLRVDPLVVLFLAAGFIFTVMSMHFVAKMTGQVF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q8TFK8</accession>
    <accession>Q6FLJ6</accession>
    <name>DED1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DED1</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DED1</name>
        <name type="ordered locus">CAGL0L02915g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Yeast" volume="19" first="991" last="994">
            <title>Genomic differences between Candida glabrata and Saccharomyces cerevisiae around the MRPL28 and GCN3 loci.</title>
            <authorList>
                <person name="Walsh D.W."/>
                <person name="Wolfe K.H."/>
                <person name="Butler G."/>
            </authorList>
            <dbReference type="PubMed" id="12125055"/>
            <dbReference type="DOI" id="10.1002/yea.890"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="AY083607">
        <property type="protein sequence ID" value="AAM08102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448898.1">
        <property type="nucleotide sequence ID" value="XM_448898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8TFK8"/>
    <dbReference type="SMR" id="Q8TFK8"/>
    <dbReference type="FunCoup" id="Q8TFK8">
        <property type="interactions" value="1346"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q8TFK8"/>
    <dbReference type="EnsemblFungi" id="CAGL0L02915g-T">
        <property type="protein sequence ID" value="CAGL0L02915g-T-p1"/>
        <property type="gene ID" value="CAGL0L02915g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890837"/>
    <dbReference type="KEGG" id="cgr:2890837"/>
    <dbReference type="CGD" id="CAL0135394">
        <property type="gene designation" value="CAGL0L02915g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L02915g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02915g"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_3_1"/>
    <dbReference type="InParanoid" id="Q8TFK8"/>
    <dbReference type="OMA" id="ISGNDRW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031370">
        <property type="term" value="F:eukaryotic initiation factor 4G binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033592">
        <property type="term" value="F:RNA strand annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901195">
        <property type="term" value="P:positive regulation of formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000232156" description="ATP-dependent RNA helicase DED1">
        <location>
            <begin position="1"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="176"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="376"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="543"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="309"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="543"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="582"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="189"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="617" mass="67002" checksum="4D20D1695C736459" modified="2002-06-01" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-10" modified="2025-06-18" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q9P974</accession>
    <accession>Q6FVJ2</accession>
    <name>IF4E_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Eukaryotic translation initiation factor 4E</fullName>
            <shortName>eIF-4E</shortName>
            <shortName>eIF4E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>eIF-4F 25 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>mRNA cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TIF45</name>
        <name type="ordered locus">CAGL0E01463g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="1999-12" db="EMBL/GenBank/DDBJ databases">
            <title>Candida glabrata eIF4E gene.</title>
            <authorList>
                <person name="Ono N."/>
                <person name="Sudoh M."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="AB036333">
        <property type="protein sequence ID" value="BAA93571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q9P974"/>
    <dbReference type="SMR" id="Q9P974"/>
    <dbReference type="FunCoup" id="Q9P974">
        <property type="interactions" value="1411"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q9P974"/>
    <dbReference type="EnsemblFungi" id="CAGL0E01463g-T">
        <property type="protein sequence ID" value="CAGL0E01463g-T-p1"/>
        <property type="gene ID" value="CAGL0E01463g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887437"/>
    <dbReference type="CGD" id="CAL0128640">
        <property type="gene designation" value="CDC33"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_E01463g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01463g"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043552_2_2_1"/>
    <dbReference type="InParanoid" id="Q9P974"/>
    <dbReference type="OMA" id="EEFWAIV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901195">
        <property type="term" value="P:positive regulation of formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000193650" description="Eukaryotic translation initiation factor 4E">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA93571." evidence="2" ref="1">
        <original>S</original>
        <variation>E</variation>
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="209" mass="23899" checksum="D09A075213EAC00E" modified="2004-08-31" version="2">MSVDEVTKKFEETVSVDGPKTVLSDAKDFEVKHPLNTKWTLWYTKPAVDKSESWSDLLRPVTSFQSVEEFWAIVQNIPEPHELPLKSDYHVFRNDIRPEWEDSANAKGGKWSFQVRGRGAEIDELWLRTLLAVIGETIDEEDSQINGVVLNVRKGGNRFALWTKSCDKEPLSNIGARFKQVLKLADEDTLEFFPHSTANDRHSQPTITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIJ5</accession>
    <name>Q6FIJ5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M13915g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIJ5"/>
    <dbReference type="FunCoup" id="Q6FIJ5">
        <property type="interactions" value="1040"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIJ5"/>
    <dbReference type="KEGG" id="cgr:2891611"/>
    <dbReference type="CGD" id="CAL0136257">
        <property type="gene designation" value="CAGL0M13915g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13915g"/>
    <dbReference type="eggNOG" id="KOG3925">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061859_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIJ5"/>
    <dbReference type="OMA" id="YGYHVRI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000040">
        <property type="entry name" value="YMR310C-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41643" checksum="0DE6512CA446DE48" modified="2004-07-19" version="1">MVEKRKLNGSGSNDKKKAKKAVVVKPKPAKKVLKVSEKTLNYAVCIPTSVLDNCQNLSQKTYVVYQLARTLTLFNVAEVVVLDLKQEKQNSIIEKDDTKKEKKRMSDAMLLASLLQYFVTPPYLIKSVFKKEYLPYFKEASKLPRLSALPFMRYMEENRYREGLAIRMSKPDPKSKKEFKQTKYINIGESDALELKSQLVPINVRVTVDIIDKKVVAPEEAYGDYVGPKASYGYHVRIAKSFADLFMGSSFPSGYTQTVWCNSGDYYYDESTKKHNKVEVHIPRLSKIIRSGPQNPEKPEDVPALLLVLGKWDHINKSFQNSKDQFEGSEHAYQFFDGQIELPGSVPQGNITIPDSCTIAMTLLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIM5</accession>
    <name>Q6FIM5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Manganese resistance protein MNR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M13233g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIM5"/>
    <dbReference type="FunCoup" id="Q6FIM5">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891209"/>
    <dbReference type="CGD" id="CAL0137261">
        <property type="gene designation" value="CAGL0M13233g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13233g"/>
    <dbReference type="eggNOG" id="ENOG502QPTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FIM5"/>
    <dbReference type="OMA" id="HNHESAS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1080"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="712"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="844"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="912"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="168"/>
            <end position="179"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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            <begin position="272"/>
            <end position="281"/>
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            <begin position="291"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
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            <begin position="323"/>
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            <begin position="847"/>
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        <location>
            <begin position="867"/>
            <end position="881"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1107" mass="125855" checksum="0B7CE40862E19700" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="153" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIW2</accession>
    <name>Q6FIW2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0M11308g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
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    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FIW2">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIW2"/>
    <dbReference type="KEGG" id="cgr:2891401"/>
    <dbReference type="CGD" id="CAL0137369">
        <property type="gene designation" value="CAGL0M11308g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11308g"/>
    <dbReference type="eggNOG" id="KOG0208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001828_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FIW2"/>
    <dbReference type="OMA" id="SGWKDPL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990816">
        <property type="term" value="C:vacuole-mitochondrion membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903135">
        <property type="term" value="F:cupric ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000125">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="684"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="720"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1216"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1252"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1290"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1336"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1368"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1397"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="295"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="540"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="147"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0137369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG62812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1452" mass="164488" checksum="8DE62ECB2A168162" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIX4</accession>
    <name>Q6FIX4_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M10978g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449820.1">
        <property type="nucleotide sequence ID" value="XM_449820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIX4"/>
    <dbReference type="STRING" id="284593.Q6FIX4"/>
    <dbReference type="KEGG" id="cgr:2891387"/>
    <dbReference type="CGD" id="CAL0136581">
        <property type="gene designation" value="CAGL0M10978g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M10978g"/>
    <dbReference type="eggNOG" id="KOG2296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_425897_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIX4"/>
    <dbReference type="OMA" id="DHICTEC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="576"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="576"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="613" mass="69670" checksum="387D7B39EF459265" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ55</accession>
    <name>FIP1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA polyadenylation factor FIP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FIP1</name>
        <name type="ordered locus">CAGL0M09064g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449739.1">
        <property type="nucleotide sequence ID" value="XM_449739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ55"/>
    <dbReference type="SMR" id="Q6FJ55"/>
    <dbReference type="FunCoup" id="Q6FJ55">
        <property type="interactions" value="257"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ55"/>
    <dbReference type="EnsemblFungi" id="CAGL0M09064g-T">
        <property type="protein sequence ID" value="CAGL0M09064g-T-p1"/>
        <property type="gene ID" value="CAGL0M09064g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891301"/>
    <dbReference type="KEGG" id="cgr:2891301"/>
    <dbReference type="CGD" id="CAL0136771">
        <property type="gene designation" value="CAGL0M09064g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09064g"/>
    <dbReference type="eggNOG" id="KOG1049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039307_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FJ55"/>
    <dbReference type="OMA" id="GFNEYTW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051187">
        <property type="entry name" value="Pre-mRNA_3'-end_processing_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484">
        <property type="entry name" value="FIP1-LIKE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13484:SF0">
        <property type="entry name" value="PRE-MRNA 3'-END-PROCESSING FACTOR FIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000238510" description="Pre-mRNA polyadenylation factor FIP1">
        <location>
            <begin position="1"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="136"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="327" mass="36101" checksum="2EA02FE46163B8D7" modified="2004-07-19" version="1">MSSSEDEDDKFLYGSDNEEPKNEKKRPREAAEDDNEGPTSDKVVSQHNNDLKRPKLAKDSLANASSDEEESGSESDSDIEFIISTGPDPHRLDSSTVPGSNNAIVTVSEGANVGGETMSKSTATATTAEISTLNALGDTEVAGTSELDNETLGPETTTKSGTSAEGIDLDKEGLYNDEPVSTIDPEVLKEKPWRQPGANISDYFNYGFNEYTWMEYLHRQEKLRQEYNPRRILMGLMTLQQQGRLDQPQGGHQSMPDNMAINNPQPTNNDNMMHKPTPPLPNFPMPPMFGGFSPFMPPGMMAPMNRMPNQNQNQGQNQNQNQNQLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJE3</accession>
    <name>Q6FJE3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cystine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M06985g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJE3"/>
    <dbReference type="FunCoup" id="Q6FJE3">
        <property type="interactions" value="226"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJE3"/>
    <dbReference type="KEGG" id="cgr:2891700"/>
    <dbReference type="CGD" id="CAL0137235">
        <property type="gene designation" value="CAGL0M06985g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06985g"/>
    <dbReference type="eggNOG" id="KOG3145">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046327_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJE3"/>
    <dbReference type="OMA" id="LAFAYHG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="29058" checksum="57892416258B52BE" modified="2004-07-19" version="1">MEFEDILGVIYVTAWSISMYPPLYINWKRKSARAISPDFVLLNLTGYFYLVCSLTLQMYKWIPHLQSNIERPKLTGFDYCYCLHGFILTVLIASQLFMSRSVWRFPDTHQFRMKPVYKKVLLLSIFLFGVLTLQFTYHNMQSGWDNERTLAYCNNLFLLKISMSLIKYIPQVLHNFERKSMQGFAISGVFLDMTGGIASIVQLIFQILKESEINLSILISNFGKIGLAMVTLIFNTIFISQWLLYEKKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJG1</accession>
    <name>FAL1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase FAL1</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FAL1</name>
        <name type="ordered locus">CAGL0M06567g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449633.1">
        <property type="nucleotide sequence ID" value="XM_449633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJG1"/>
    <dbReference type="SMR" id="Q6FJG1"/>
    <dbReference type="FunCoup" id="Q6FJG1">
        <property type="interactions" value="731"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJG1"/>
    <dbReference type="EnsemblFungi" id="CAGL0M06567g-T">
        <property type="protein sequence ID" value="CAGL0M06567g-T-p1"/>
        <property type="gene ID" value="CAGL0M06567g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891681"/>
    <dbReference type="KEGG" id="cgr:2891681"/>
    <dbReference type="CGD" id="CAL0136531">
        <property type="gene designation" value="CAGL0M06567g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M06567g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06567g"/>
    <dbReference type="eggNOG" id="KOG0328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FJG1"/>
    <dbReference type="OMA" id="DTIHGDK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097078">
        <property type="term" value="C:FAL1-SGD1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030874">
        <property type="term" value="C:nucleolar chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000232144" description="ATP-dependent RNA helicase FAL1">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="238"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="399" mass="45312" checksum="90A47E551A6BD4BE" modified="2004-07-19" version="1">MSFNREHDLKLKFKSSKKLKISATFESMDLKEGLLRGIYSYGFEAPSAIQSRAITQIISGKDVIAQAQSGTGKTATFTIGMLQAIDLKKHDLQALVLSPTRELAAQIGKVVTNLGDYMNVKAYAMTGGKTMKDDLKKIQKHGCQVISGTPGRVLDMIKRRLIETRHVQILVLDEADELLSDTLGFKHQIYDIFTKLPRTSQVVVVSATMSPEILEITKKFMNDPVKILVKRDEITLEGIKQYYVNVEKEEWKFDTLCDIYDSLTITQCVIFCNSKKKVDWLAHKLKQSNFAVISMHGDMKQDERDRVMNEFRTGQSRVLISTDVWARGIDVQQVSLVINYDLPEITENYVHRIGRSGRFGRKGVAINFLTKIDASRMKEIEKYYKIKVKPMPADLSELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJM6</accession>
    <name>Q6FJM6_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M05115g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449568.1">
        <property type="nucleotide sequence ID" value="XM_449568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJM6"/>
    <dbReference type="STRING" id="284593.Q6FJM6"/>
    <dbReference type="KEGG" id="cgr:2891580"/>
    <dbReference type="CGD" id="CAL0137447">
        <property type="gene designation" value="CAGL0M05115g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05115g"/>
    <dbReference type="eggNOG" id="ENOG502S6TM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_633124_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJM6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035179">
        <property type="entry name" value="DUF5314"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17241">
        <property type="entry name" value="Retrotran_gag_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="433" mass="49436" checksum="C3C53B5198051B06" modified="2004-07-19" version="1">MELVYPLLCQTIANGELASLKQQVMSLAANTYDASTTIKLTEVGDYKKWIQMLESTLTMAHSAWSEFYHAGPYDVKTISDPTVKIQLSFLNDALVCLIKKRVSDDAVKNINKIILSLTNFSNSAFKILDYLKGRYDRNNSRTSFKQNYGWITNYQSMTHEDLFREITSMMEALLNYDEYELALLNTIPKDDQAKFIVRKENLIKQSAAGMMLGYLPEHLREGYFKQWGHTAEFQTYEIVDIVVGSNVNNSQSVNHGSLANAENKNYKKQNRDKKPHFRKQKTKPKCLYCGKPHKLSECKILFQDNPDAEVFKTFGPPSIDEELSGAYEYTIQEKPETLIWNSGASTHMCCNKQFFIEYKDLKAHTSEISQYPTTSCREAREASIHAYKEPASRHHDQDHTQNPARGLKELDSVAIIKSGGSTTYSVQAVWRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJN5</accession>
    <name>Q6FJN5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M04873g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eS10 plays a role as a positive regulator of the GCN2 kinase activity by stimulating GCN1-mediated GCN2 activation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). eS10 interacts with GCN1 (via middle region); this interaction is direct and promotes GCN2 kinase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449559.1">
        <property type="nucleotide sequence ID" value="XM_449559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJN5"/>
    <dbReference type="FunCoup" id="Q6FJN5">
        <property type="interactions" value="1036"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJN5"/>
    <dbReference type="KEGG" id="cgr:2891569"/>
    <dbReference type="CGD" id="CAL0137051">
        <property type="gene designation" value="CAGL0M04873g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04873g"/>
    <dbReference type="eggNOG" id="KOG3344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089349_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FJN5"/>
    <dbReference type="OMA" id="ERTKIHR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0137051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="105" mass="12655" checksum="7C00F8D6FDC2D2C7" modified="2004-07-19" version="1">MLMPKEERTKIHRHLFQEGVVVAKKDFNQPKHDEIDTKNLYVIKALQSLTSKGYVKTQFSWQYYYYTLTEEGVEYLREYLNLPEHIVPGTYIQNAQQAQRPNRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJR9</accession>
    <name>Q6FJR9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HXT14</name>
        <name evidence="10 11" type="ordered locus">CAGL0M04103g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449525.1">
        <property type="nucleotide sequence ID" value="XM_449525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJR9"/>
    <dbReference type="FunCoup" id="Q6FJR9">
        <property type="interactions" value="1477"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJR9"/>
    <dbReference type="GeneID" id="2891534"/>
    <dbReference type="KEGG" id="cgr:2891534"/>
    <dbReference type="CGD" id="CAL0137283">
        <property type="gene designation" value="HXT14"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04103g"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="Q6FJR9"/>
    <dbReference type="OMA" id="IFGWDVG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005354">
        <property type="term" value="F:galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF50">
        <property type="entry name" value="HEXOSE TRANSPORTER HXT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="63"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0137283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="531" mass="58969" checksum="37ACB37D2043C5AF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK06</accession>
    <name>AIM44_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM44</name>
        <name type="ordered locus">CAGL0M02123g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIM44 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449438.1">
        <property type="nucleotide sequence ID" value="XM_449438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK06"/>
    <dbReference type="FunCoup" id="Q6FK06">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK06"/>
    <dbReference type="EnsemblFungi" id="CAGL0M02123g-T">
        <property type="protein sequence ID" value="CAGL0M02123g-T-p1"/>
        <property type="gene ID" value="CAGL0M02123g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891764"/>
    <dbReference type="KEGG" id="cgr:2891764"/>
    <dbReference type="CGD" id="CAL0136827">
        <property type="gene designation" value="CAGL0M02123g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M02123g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02123g"/>
    <dbReference type="eggNOG" id="ENOG502R02U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_385965_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK06"/>
    <dbReference type="OMA" id="MDFKFPS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032174">
        <property type="term" value="C:cellular bud neck septin collar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032177">
        <property type="term" value="C:cellular bud neck split septin rings"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045185">
        <property type="term" value="P:maintenance of protein location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903473">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098841">
        <property type="term" value="P:protein localization to cell division site after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901900">
        <property type="term" value="P:regulation of protein localization to cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990344">
        <property type="term" value="P:secondary cell septum biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000408695" description="Altered inheritance of mitochondria protein 44">
        <location>
            <begin position="1"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="678" mass="75302" checksum="DD1A1D6CED215C85" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK31</accession>
    <name>Q6FK31_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M01562g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK31"/>
    <dbReference type="FunCoup" id="Q6FK31">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891182"/>
    <dbReference type="CGD" id="CAL0136509">
        <property type="gene designation" value="CAGL0M01562g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01562g"/>
    <dbReference type="eggNOG" id="ENOG502RYMB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069195_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK31"/>
    <dbReference type="OMA" id="YGVGEVN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052564">
        <property type="entry name" value="N-acetyltrans/Recomb-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43451:SF1">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43451">
        <property type="entry name" value="ACETYLTRANSFERASE (GNAT) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0136509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="217" mass="25210" checksum="BBCBC1C0BB3D65F2" modified="2004-07-19" version="1">MSEVKLNITRDVVRASETLYKAFDDSHAFDYITKKFFNLPVDEYVSKDRINAITHYYVACYHDSNGEVVEANDYDAVAVFSLPNQHLPKSLTNDPHFNQVFFHDLKSRLAEVIPEDIHYYYLFMIGKDLTRKDTKGSVRKIFEEYKKRADAENCAIVLEAIAEHARSVYEYFGFKNYKTFHYGVGEVNEQGQPDPNGKGFTGYLMIYHKDGDKVLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKD8</accession>
    <name>Q6FKD8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyl-CoA acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ergosterol biosynthesis protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ERG10</name>
        <name evidence="12 13" type="ordered locus">CAGL0L12364g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="2"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449306.1">
        <property type="nucleotide sequence ID" value="XM_449306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKD8"/>
    <dbReference type="FunCoup" id="Q6FKD8">
        <property type="interactions" value="624"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKD8"/>
    <dbReference type="GeneID" id="2890696"/>
    <dbReference type="KEGG" id="cgr:2890696"/>
    <dbReference type="CGD" id="CAL0135698">
        <property type="gene designation" value="ERG10"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12364g"/>
    <dbReference type="eggNOG" id="KOG1390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FKD8"/>
    <dbReference type="OMA" id="ICPSIAI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF165">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="274"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00084041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0135698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG62280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="398" mass="41635" checksum="F55EA8649EBEE3F4" modified="2004-07-19" version="1">MSDTVYIVSAARTPIGSFQGALASKTAVDLGVIAVKGAMQKVPQLNPESDYDEVFFGNVISANLGQNAARQVALGAGLKNGIVATSVNKVCASAMKSIILGAQAIKCGTADVVIAGGCESMTNAPYYMPAARAGARFGETKMVDGIQRDGLNDAYDHQPMGVHAEKCARNWEITREQQDDFAIASYQKAQKAQQEGKFDNEIVPVTIKGFRGKPDTQVTKDEEPTKLNVDKLRSARTVFQKENGTVTAPNASPINDGAAAVILVSEKKLKELNLTPLATLKGWGEAAHDPADFTWAPSLAIPKALKHAGVADISQVDYIELNEAFSVVGCANTKILKVDPAKVNVYGGAVAIGHPLGCSGARVVVTLLSVLQQEGGKIGVAGICNGGGGASSVVIERV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKP2</accession>
    <name>PAN3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="1">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PAN3</name>
        <name type="ordered locus">CAGL0L09889g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449202.1">
        <property type="nucleotide sequence ID" value="XM_449202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKP2"/>
    <dbReference type="SMR" id="Q6FKP2"/>
    <dbReference type="FunCoup" id="Q6FKP2">
        <property type="interactions" value="691"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKP2"/>
    <dbReference type="EnsemblFungi" id="CAGL0L09889g-T">
        <property type="protein sequence ID" value="CAGL0L09889g-T-p1"/>
        <property type="gene ID" value="CAGL0L09889g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891085"/>
    <dbReference type="KEGG" id="cgr:2891085"/>
    <dbReference type="CGD" id="CAL0135162">
        <property type="gene designation" value="CAGL0L09889g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09889g"/>
    <dbReference type="eggNOG" id="KOG3741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016423_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FKP2"/>
    <dbReference type="OMA" id="NIPCRNE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25586">
        <property type="entry name" value="zf-CCCH_PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000295363" description="PAN2-PAN3 deadenylation complex subunit PAN3">
        <location>
            <begin position="1"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pseudokinase domain" evidence="1">
        <location>
            <begin position="323"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="1">
        <location>
            <begin position="625"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="586"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="428"/>
            <end position="435"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="482"/>
            <end position="483"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="717" mass="79802" checksum="2D7FB968521F824A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKS2</accession>
    <name>Q6FKS2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0L09130g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449172.1">
        <property type="nucleotide sequence ID" value="XM_449172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKS2"/>
    <dbReference type="FunCoup" id="Q6FKS2">
        <property type="interactions" value="1229"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKS2"/>
    <dbReference type="KEGG" id="cgr:2891104"/>
    <dbReference type="CGD" id="CAL0136042">
        <property type="gene designation" value="CAGL0L09130g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09130g"/>
    <dbReference type="eggNOG" id="KOG2168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011846_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKS2"/>
    <dbReference type="OMA" id="LLMCGQF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044612">
        <property type="term" value="C:nuclear pore linkers"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044615">
        <property type="term" value="C:nuclear pore nuclear basket"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0136042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="846" mass="96525" checksum="AE0197917E87610E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2025-06-18" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKY1</accession>
    <name>PGK_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Phosphoglycerate kinase</fullName>
            <ecNumber evidence="4">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PGK1</name>
        <name type="ordered locus">CAGL0L07722g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3 4">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate (By similarity). Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines (By similarity). Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="4"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449113.1">
        <property type="nucleotide sequence ID" value="XM_449113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKY1"/>
    <dbReference type="SMR" id="Q6FKY1"/>
    <dbReference type="FunCoup" id="Q6FKY1">
        <property type="interactions" value="858"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKY1"/>
    <dbReference type="EnsemblFungi" id="CAGL0L07722g-T">
        <property type="protein sequence ID" value="CAGL0L07722g-T-p1"/>
        <property type="gene ID" value="CAGL0L07722g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891002"/>
    <dbReference type="KEGG" id="cgr:2891002"/>
    <dbReference type="CGD" id="CAL0135168">
        <property type="gene designation" value="PGK1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L07722g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07722g"/>
    <dbReference type="eggNOG" id="KOG1367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FKY1"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000145877" description="Phosphoglycerate kinase">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
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        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
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        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
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    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
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        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
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    </feature>
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        <location>
            <position position="121"/>
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        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
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    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
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        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
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            <name>(2R)-3-phosphoglycerate</name>
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    </feature>
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            <position position="169"/>
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        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
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    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="212"/>
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        <ligand>
            <name>ADP</name>
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    </feature>
    <feature type="binding site" evidence="3">
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            <position position="212"/>
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        <ligand>
            <name>CDP</name>
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    </feature>
    <feature type="binding site" evidence="5">
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            <position position="213"/>
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        <ligand>
            <name>AMP</name>
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    </feature>
    <feature type="binding site" evidence="5">
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        <ligand>
            <name>ATP</name>
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        <ligand>
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        <ligand>
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    </feature>
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        <ligand>
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    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
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            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
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            <name>CDP</name>
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            <position position="237"/>
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        <ligand>
            <name>AMP</name>
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        <ligand>
            <name>ATP</name>
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            <position position="311"/>
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        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
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            <position position="311"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <position position="336"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
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            <position position="341"/>
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            <name>ADP</name>
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            <position position="341"/>
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            <name>CDP</name>
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        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
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        </location>
        <ligand>
            <name>ATP</name>
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            <name>ATP</name>
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        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="A0A7G5KET3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="P00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="5">
        <source>
            <dbReference type="UniProtKB" id="Q7SIB7"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="416" mass="44617" checksum="1510C01064D0574A" modified="2004-07-19" version="1">MSLSSKLTVQDLELKDKRVFIRVDFNVPLDGKKITSNQRIVAALPTIKYVLEHNPRYVVLASHLGRPNGERNEKYSLAPVAEELQSLLGKPVTFLNDCVGSEVDSAVKASAPGSVILLENLRYHIEEEGSRKVDGQKVKASAEDVAKFRKELCSLADVYINDAFGTAHRAHSSMVGFDLPQRAAGFLLTKELQYFGKALENPTRPFLAILGGAKVADKIQLIDNLLDKVDSIIIGGGMAFTFKKVLENAEIGDSIFDKAGAEIVPKLMEKAKAKGVEVVLPVDFVIADAFSADANTKIVSDKEGIPAGWQGLDNGPESRKLFAATIAKAKTIVWNGPPGVFEFEKFASGTKAMLDEVVKSSTSGNTVIIGGGDTATVAKKYGVTDKISHVSTGGGASLELLEGKELPGVAFLSEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLC0</accession>
    <name>Q6FLC0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L04576g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLC0"/>
    <dbReference type="FunCoup" id="Q6FLC0">
        <property type="interactions" value="1530"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890644"/>
    <dbReference type="CGD" id="CAL0135478">
        <property type="gene designation" value="CAGL0L04576g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04576g"/>
    <dbReference type="eggNOG" id="ENOG502SJDI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010594_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLC0"/>
    <dbReference type="OMA" id="YNSGWEE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052693">
        <property type="entry name" value="Yeast_MDR_Regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31405">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31405:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0135478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="865" mass="98313" checksum="E7BC65B8888DEED1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLP4</accession>
    <name>Q6FLP4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Scaffold protein Nfu/NifU N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NFU1</name>
        <name evidence="4 5" type="ordered locus">CAGL0L01859g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448850.1">
        <property type="nucleotide sequence ID" value="XM_448850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLP4"/>
    <dbReference type="FunCoup" id="Q6FLP4">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLP4"/>
    <dbReference type="GeneID" id="2890672"/>
    <dbReference type="KEGG" id="cgr:2890672"/>
    <dbReference type="CGD" id="CAL0136194">
        <property type="gene designation" value="NFU1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01859g"/>
    <dbReference type="eggNOG" id="KOG2358">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLP4"/>
    <dbReference type="OMA" id="AIMEHYM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000001">
        <property type="entry name" value="NFU1 iron-sulfur cluster scaffold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.70">
        <property type="entry name" value="Scaffold protein Nfu/NifU, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014824">
        <property type="entry name" value="Nfu/NifU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036498">
        <property type="entry name" value="Nfu/NifU_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035433">
        <property type="entry name" value="NFU1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178">
        <property type="entry name" value="IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11178:SF1">
        <property type="entry name" value="NFU1 IRON-SULFUR CLUSTER SCAFFOLD HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08712">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036773">
        <property type="entry name" value="HIRIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00932">
        <property type="entry name" value="Nfu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110836">
        <property type="entry name" value="Hypothetical protein SAV1430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffold protein Nfu/NifU N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0136194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="263" mass="29606" checksum="1EE0699158141283" modified="2004-07-19" version="1">MITNRLMNKCVSSPLRSVTWRRLITIQTLTTPNENALKFLNKDNELLQTRGSKSIVIKNTDQNLISHSDLASKIFAQCPGVESLMIGDDFLTVNKDSQVPWAQIQSDVIDLLTQQLASGKNVISDEFHAIKEDNEAGYQINEMKFDLTEEDEEIKELIEELIETRIRPAILEDGGDIDFRGWDPESGTVYLKLQGACTSCSSSEVTLKYGIESMLKHYVDEVKEVIQMMDPEQEIALKEFDKLEKKLQSKDENDGTTAPASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLR4</accession>
    <name>Q6FLR4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0L01309g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLR4"/>
    <dbReference type="FunCoup" id="Q6FLR4">
        <property type="interactions" value="1091"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLR4"/>
    <dbReference type="KEGG" id="cgr:2890921"/>
    <dbReference type="CGD" id="CAL0135374">
        <property type="gene designation" value="CAGL0L01309g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01309g"/>
    <dbReference type="eggNOG" id="KOG0011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040364_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLR4"/>
    <dbReference type="OMA" id="PHMLEPI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120125">
        <property type="term" value="C:PNGase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14378">
        <property type="entry name" value="UBA1_Rhp23p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.540:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="139"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="349"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0135374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="392" mass="42039" checksum="EDC5ABE7A166B759" modified="2004-07-19" version="1">MVSVTFKNFKKEKYPLDLESSQSIVAVKEALSEKLSCDPSQIKLIFSGKVLKDGDSVESCNFKDGNEVIFMVSAKKATATKVTESSAPKAQSEETPSESTPATSTQPETNQNETTEPATNSSSENTEAPNAGTDDGFVVGSERNATIERIMEMGYERAEVERALRAAFNNPDRAVEYLLMGIPETLRPQEGQTSQEHEADVDMNEEESTEGNAEPPAEDDLFAQAARDSATPSAAQTAGGTTSESAGSATGGPPGSIGLTMEDLLALRQVVSGNPEALAPLLENLSNRYPQLREQIMANPEVFVSMLLEAVGDNLQGAMDFEAIAEGEGDTVEGADGFAEENAPITLSPEDEQAISRLCELGFERTLVIQVYFACDKNEEIAANMLFSDYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMB6</accession>
    <name>Q6FMB6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTP-binding protein YPT31/YPT8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0K09394g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448628.1">
        <property type="nucleotide sequence ID" value="XM_448628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMB6"/>
    <dbReference type="STRING" id="284593.Q6FMB6"/>
    <dbReference type="KEGG" id="cgr:2890260"/>
    <dbReference type="CGD" id="CAL0134743">
        <property type="gene designation" value="CAGL0K09394g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09394g"/>
    <dbReference type="eggNOG" id="KOG0087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_23_0_1"/>
    <dbReference type="InParanoid" id="Q6FMB6"/>
    <dbReference type="OMA" id="DSPDMRK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="188"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24471" checksum="64DE96497FAAD968" modified="2004-07-19" version="1">MNSSEDYGYDYDYLFKIVLIGDSGVGKSNLLSRFTTNEFNLESKSTIGVEFATRTIKVEDKKIKAQIWDTAGQERYRAITSAYYRGAVGALIVYDISKSGTYENCNHWLTELKENADDNVAIGLIGNKSDLEHLRAVPTEEARGFASENQLFFTETSALNSENVDLAFRELIEQIYKMVNKHQVDLGENAKGSSGAPKGPTISLAPVPGEKKKKSKSNSCC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMH9</accession>
    <name>ASA1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ASA1</name>
        <name type="ordered locus">CAGL0K07920g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448565.1">
        <property type="nucleotide sequence ID" value="XM_448565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMH9"/>
    <dbReference type="FunCoup" id="Q6FMH9">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMH9"/>
    <dbReference type="EnsemblFungi" id="CAGL0K07920g-T">
        <property type="protein sequence ID" value="CAGL0K07920g-T-p1"/>
        <property type="gene ID" value="CAGL0K07920g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890367"/>
    <dbReference type="KEGG" id="cgr:2890367"/>
    <dbReference type="CGD" id="CAL0134547">
        <property type="gene designation" value="CAGL0K07920g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07920g"/>
    <dbReference type="eggNOG" id="ENOG502QU4T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045414_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FMH9"/>
    <dbReference type="OMA" id="LVCCNTQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000402207" description="ASTRA-associated protein 1">
        <location>
            <begin position="1"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="11"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="60"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="443"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="475" mass="53471" checksum="43807AC9133A4BCB" modified="2004-07-19" version="1">MERAATHFLRLHKSGISALCSGVIDPDYGITSPVLFSGDIDGEVTIWNLITRRPIFTSKICNEQVVDIQFLEGKYLSLLCKDHKLRLYELLKLGAIVKQSDFGGGDKVDLKQIFEVPVNTLNFANYVLTYLGNNKFELVTCHTQDAHFIDIYEFETPELNSLKRFSKAIDFLPMLRDRFGDNLLPKMDGLGIIMKFYKVNEVVYCGFESGYVIAFRRYRNKPLYRKRVSGFIGKPINECASGISKLLQHENVETSSSVNDLELDNVIEIVLVDRAHYPDPVLDMAPNPKKNGIICSSTTNKLVLTSVDEQYLAGPNSAYIFKSDEYLLDKKNCLLMSTNLKIDGSAVKDMMCKNIGFVLSLGDYIITGNWSGKTYIGRIESDKAVLAAAKSRSLIEVNESPVGNIQQDKSIQKSSKHTKIGAMTGFEVKDKEPDKLMCKNKELTPGKLRRLNAFVQSKWYFIGYTDGTIGLYRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMN7</accession>
    <name>Q6FMN7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">COMPASS component SDC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0K06523g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMN7"/>
    <dbReference type="STRING" id="284593.Q6FMN7"/>
    <dbReference type="KEGG" id="cgr:2890439"/>
    <dbReference type="CGD" id="CAL0134109">
        <property type="gene designation" value="CAGL0K06523g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06523g"/>
    <dbReference type="eggNOG" id="KOG4109">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162876_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMN7"/>
    <dbReference type="OMA" id="WLNEHVT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042800">
        <property type="term" value="F:histone H3K4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22965">
        <property type="entry name" value="DD_DPY30_SDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049629">
        <property type="entry name" value="DPY30_SDC1_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0134109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG61468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12191" checksum="75C883EA692BA98E" modified="2004-07-19" version="1">MEISDVLSKEPEACAPPPSEPVVKPEPEVKQEKQDIKTESPVATPAISLTEQKPATGSGINLVETIGGSQTRRYLNDKVTPVLLEGMRKIAVEQPADPLRVLGEYLIERSDN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-05-10" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMP4</accession>
    <accession>Q8TFL7</accession>
    <name>TFB3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TFB3</name>
        <name type="ordered locus">CAGL0K06369g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="Yeast" volume="19" first="991" last="994">
            <title>Genomic differences between Candida glabrata and Saccharomyces cerevisiae around the MRPL28 and GCN3 loci.</title>
            <authorList>
                <person name="Walsh D.W."/>
                <person name="Wolfe K.H."/>
                <person name="Butler G."/>
            </authorList>
            <dbReference type="PubMed" id="12125055"/>
            <dbReference type="DOI" id="10.1002/yea.890"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 97-330</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH as CTD kinase activity and DNA-dependent ATPase activity, and is essential for polymerase II transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY083606">
        <property type="protein sequence ID" value="AAM08093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448500.1">
        <property type="nucleotide sequence ID" value="XM_448500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMP4"/>
    <dbReference type="SMR" id="Q6FMP4"/>
    <dbReference type="FunCoup" id="Q6FMP4">
        <property type="interactions" value="578"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMP4"/>
    <dbReference type="EnsemblFungi" id="CAGL0K06369g-T">
        <property type="protein sequence ID" value="CAGL0K06369g-T-p1"/>
        <property type="gene ID" value="CAGL0K06369g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890432"/>
    <dbReference type="KEGG" id="cgr:2890432"/>
    <dbReference type="CGD" id="CAL0134781">
        <property type="gene designation" value="CAGL0K06369g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K06369g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06369g"/>
    <dbReference type="eggNOG" id="KOG3800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048466_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FMP4"/>
    <dbReference type="OMA" id="PNKRDYY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001174">
        <property type="term" value="P:transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003338">
        <property type="entry name" value="MAT1_metazoa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000055937" description="RNA polymerase II transcription factor B subunit 3">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <sequence length="330" mass="38837" checksum="3C5FAFBF95365888" modified="2004-07-19" version="1">MSSAVASKGMNQGSEFDDNKDMCPICKTDRYLSPDVRFLVNPECYHKICESCVDRIFSLGPAPCPYKSCDKILRKNKFKTQIFDDVGVEKEVDIRKRVFNVFNKTLEDFDNDLEAYNKYLEEVEDIVYKLDNKIDVVETEEKLRTYEELNKQLIMNNMERSKKDLENFEQRQQFEKEMRMKKRMLERQIESEDKMNKEWAKREIVNRLASSTNADDVIEGVKNTVKLKKSSARRKLEEINRVLQNNPYSSLMLSQGLSRKEDNVPFTPFNGDRDLDKRYTIDQESYDDPFIKDLENRKDYIASGFRSDFVYDRMLTEAFMGLGCVVAEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMW0</accession>
    <name>Q6FMW0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIOREX complex component 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0K04785g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMW0"/>
    <dbReference type="FunCoup" id="Q6FMW0">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890013"/>
    <dbReference type="CGD" id="CAL0134893">
        <property type="gene designation" value="CAGL0K04785g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04785g"/>
    <dbReference type="eggNOG" id="ENOG502S73A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177980_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMW0"/>
    <dbReference type="OMA" id="RILFWDE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020301">
        <property type="entry name" value="Mrx7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10906">
        <property type="entry name" value="Mrx7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0134893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="10396" checksum="28596B3ECDF2EC06" modified="2004-07-19" version="1">MRPPRNLEEWLYCKLLESEGFHRFVRKVYNKVNGIKETPLQHQANPSEFLYKPTRLHKFRAYRILFWDEMRASLNLPKKSSKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN03</accession>
    <name>Q6FN03_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin POM152</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">POM152</name>
        <name evidence="7 8" type="ordered locus">CAGL0K03817g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448391.1">
        <property type="nucleotide sequence ID" value="XM_448391.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FN03">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN03"/>
    <dbReference type="GeneID" id="2890141"/>
    <dbReference type="KEGG" id="cgr:2890141"/>
    <dbReference type="CGD" id="CAL0134165">
        <property type="gene designation" value="POM152"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03817g"/>
    <dbReference type="eggNOG" id="ENOG502QQ5B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002415_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN03"/>
    <dbReference type="OMA" id="DRSNCKR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056541">
        <property type="entry name" value="Ig-like_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056542">
        <property type="entry name" value="Ig-like_POM152_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056543">
        <property type="entry name" value="Ig-like_POM152_9th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056544">
        <property type="entry name" value="Ig_POM152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037701">
        <property type="entry name" value="Pom152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056540">
        <property type="entry name" value="TMD_POM152"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28206:SF1">
        <property type="entry name" value="NUCLEOPORIN POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24312">
        <property type="entry name" value="Ig-like_POM152"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24519">
        <property type="entry name" value="Ig-like_Pom152_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24527">
        <property type="entry name" value="Ig-like_Pom152_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23664">
        <property type="entry name" value="Ig_Pom152"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24097">
        <property type="entry name" value="TMD_POM152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin POM152 N-terminal transmembrane" evidence="3">
        <location>
            <begin position="100"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 first Ig-like" evidence="5">
        <location>
            <begin position="244"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="518"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="594"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="702"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 Ig-like" evidence="4">
        <location>
            <begin position="804"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 immunoglobulin-like" evidence="2">
        <location>
            <begin position="932"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin POM152 ninth Ig-like" evidence="6">
        <location>
            <begin position="1130"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1317" mass="147983" checksum="AEA7D97404CF9B66" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN38</accession>
    <name>TVP18_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Golgi apparatus membrane protein TVP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TVP18</name>
        <name type="ordered locus">CAGL0K03025g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448356.1">
        <property type="nucleotide sequence ID" value="XM_448356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN38"/>
    <dbReference type="FunCoup" id="Q6FN38">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN38"/>
    <dbReference type="GlyCosmos" id="Q6FN38">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0K03025g-T">
        <property type="protein sequence ID" value="CAGL0K03025g-T-p1"/>
        <property type="gene ID" value="CAGL0K03025g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890218"/>
    <dbReference type="KEGG" id="cgr:2890218"/>
    <dbReference type="CGD" id="CAL0134597">
        <property type="gene designation" value="CAGL0K03025g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K03025g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03025g"/>
    <dbReference type="eggNOG" id="ENOG502S3AC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118698_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FN38"/>
    <dbReference type="OMA" id="IYAQWLG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000343016" description="Golgi apparatus membrane protein TVP18">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="167" mass="18717" checksum="5BACC2E0D555744D" modified="2004-07-19" version="1">MALGITQFINIAGLLKDLKSFNFSVYGKWFGYINIFLCIALGIANLFHVSAVIAFGIVGIVQGLIILFIEIPFLLKICPLSDRFIEFIKRFETNGYRCIFYTLMAIVQYCSLAVMTTSLLVLGITLTISAVSYGIAFTKHQEFANTNIIKNPTDEDFPHDAVVREML</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNG8</accession>
    <name>Q6FNG8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase I-specific transcription initiation factor RRN11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J11792g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNG8"/>
    <dbReference type="FunCoup" id="Q6FNG8">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNG8"/>
    <dbReference type="KEGG" id="cgr:2889466"/>
    <dbReference type="CGD" id="CAL0133282">
        <property type="gene designation" value="CAGL0J11792g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11792g"/>
    <dbReference type="eggNOG" id="ENOG502R1IK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034126_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNG8"/>
    <dbReference type="OMA" id="EVWFIYA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016850">
        <property type="entry name" value="TIF_Rrn11_budding_yeast"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027133">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="60433" checksum="A29C539F75B9EBEE" modified="2004-07-19" version="1">MFEVPITYNCRRLNVERRVRYQYINILSRKYHAKRRSKRRRQANSLPTPENSAVENDQSESQLPSREQIKEKKMKLGEDYSDSEAETSSEGEDTTKDDNEFANDMNKFEKLFYRKYEKPEHSFEVWYDGNSVNTKKKHELKKTHIHYTRLNRVERIAKKRVEKNVVHMPLVNKRYFDIKSEGYEVLEPLVDIDSYLLKHIEILTQILFSSVSQGNWDIAYRTFSLLIRIPEVDIRNIWGLGTRILMERGQTTRSLEFLKWMSTVYSSKQNFVQSHCHRKAPVFRSGSRTHTPKYALTWLWNCLIKVTELISIEEEKGVNTNEEENDNGSKQSAMDKLTELIDKISEMVLVPPYLDDPEIWFIYSMCHMVHADYLSGKFNCQRLSGSRRDIARNQVTQHIHYVKTYLQNCSQKGNFEYPKQFIQSRLEEFEKRMYEDESKPENMKLQESYDNTSYSNEDDEENPFQIDESNSFLGNLVEEGIDPVIKTHWEPTMNMDALKFNYNSTDDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNN6</accession>
    <name>Q6FNN6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MKS1</name>
        <name evidence="3 4" type="ordered locus">CAGL0J10274g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448158.1">
        <property type="nucleotide sequence ID" value="XM_448158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNN6"/>
    <dbReference type="FunCoup" id="Q6FNN6">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNN6"/>
    <dbReference type="GeneID" id="2889417"/>
    <dbReference type="KEGG" id="cgr:2889417"/>
    <dbReference type="CGD" id="CAL0132806">
        <property type="gene designation" value="MKS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10274g"/>
    <dbReference type="eggNOG" id="ENOG502RFNU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023053_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNN6"/>
    <dbReference type="OMA" id="MFLPNNI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000220">
        <property type="term" value="P:regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="659" mass="74585" checksum="718A00723752FAEE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNN9</accession>
    <name>Q6FNN9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0J10208g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNN9"/>
    <dbReference type="FunCoup" id="Q6FNN9">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNN9"/>
    <dbReference type="KEGG" id="cgr:2889414"/>
    <dbReference type="CGD" id="CAL0132830">
        <property type="gene designation" value="CAGL0J10208g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10208g"/>
    <dbReference type="eggNOG" id="KOG2299">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FNN9"/>
    <dbReference type="OMA" id="RYSWQTA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990516">
        <property type="term" value="P:ribonucleotide excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00729">
        <property type="entry name" value="ribonuclease HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="10">
        <location>
            <begin position="40"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0132830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="307" mass="34573" checksum="E786AF1972264AD2" modified="2004-07-19" version="1">MTVTEEKNVLPPTVQVSLNSLKTKTYYSEIPKSVIANESPVILGVDEAGRGPVMGPMVYGISYCTKEYQDKVLIPKYTFDDSKKLTDPVRRMLFSKMYAGEIDQVGYATTAITPYDISTGMSRYPPSRNYNLNEQAHDVTMALIQGVIDRGVSIDHVYVDTVGPPASYQRKLEDRFPSIKFTVAKKADSLYCVVSVASVVAKVTRDLLIESLRRTPDEIMGSGYPSDPKTVAWLKGNQKPLLGWPIEIVRFSWQTCQTLLKDKSTGSVSIKWDEDYTNTKRKLVPIPVPETNFYEKPPTLDNWFMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNW5</accession>
    <name>Q6FNW5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J08547g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNW5"/>
    <dbReference type="FunCoup" id="Q6FNW5">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNW5"/>
    <dbReference type="KEGG" id="cgr:2889712"/>
    <dbReference type="CGD" id="CAL0133154">
        <property type="gene designation" value="CAGL0J08547g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08547g"/>
    <dbReference type="eggNOG" id="ENOG502QT3R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061432_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNW5"/>
    <dbReference type="OMA" id="DQVTHGD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="58"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="379" mass="43436" checksum="A9C69B154F265EB1" modified="2004-07-19" version="1">MEARVNEKYEREVKTTAAVWPRSRNAVLNPDVDRLCVVYEVFTRCTGNGGSKKKKVNLVFCHGSGMNRAIWEYHADRIADLNSNWVVDKIVVIDQVNHGDSALLNKGRLGLEFDWFDGARDICKVAEEEFNFMNNYNVIVGHSMGGFQTLAAVAHNPNLFQLAIVIEPVIIKDPSQLEPKTEYLFFPPNFYRALTAKMTDNFDSMQEFEEFMEKKSFYVKVHPEIRKRLTEFEAIQRPDGSVVTKMKKVHNFMCYATDNTSAKRMVQLMPFIGIPVVSLVGASSRWTPPVNNEYVRTRIPNCKEVSVANGDHLMNLEMPDTIVDYISKHISQYVANPPQRSEGDYVLDHNGSLAERNQFLDNSYKHFLNKIRLPQKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNW8</accession>
    <name>Q6FNW8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0J08437g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNW8"/>
    <dbReference type="FunCoup" id="Q6FNW8">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNW8"/>
    <dbReference type="KEGG" id="cgr:2889708"/>
    <dbReference type="CGD" id="CAL0133600">
        <property type="gene designation" value="CAGL0J08437g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08437g"/>
    <dbReference type="eggNOG" id="KOG3030">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021458_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FNW8"/>
    <dbReference type="OMA" id="YGLDICQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF155">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="115"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0133600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="267" mass="30523" checksum="AF617366A1B5BDBA" modified="2004-07-19" version="1">MKVSFGLALEYTRMYSPQLLATVFCSILFLFTEFKLVPRLENKRFRLDDKSIGKSHISNELISGFEVITMSALISGLIVVWFCTFGKDSLRKFHGNWTNMKPESSSTRGHFFFISVLCLYLILSLNGAVTGCLKLVIGNFRPDFIARCEPALDKASDLTKYYGLDICQQQNKRLLYEGLKSTPSGHSSFITSGLGFAYYWQKQFVSSHHTRHIWCIVLILLVMMSRITDHRHHWYDVVSGCIIGIAMIAASWRWVFSPRSSTYELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNZ0</accession>
    <name>Q6FNZ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein DSL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J07964g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNZ0"/>
    <dbReference type="FunCoup" id="Q6FNZ0">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNZ0"/>
    <dbReference type="KEGG" id="cgr:2889861"/>
    <dbReference type="CGD" id="CAL0133424">
        <property type="gene designation" value="CAGL0J07964g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07964g"/>
    <dbReference type="eggNOG" id="ENOG502QR7Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_357169_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNZ0"/>
    <dbReference type="OMA" id="NHLKDIM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032581">
        <property type="term" value="P:ER-dependent peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2230">
        <property type="entry name" value="Retrograde transport protein Dsl1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021876">
        <property type="entry name" value="Dsl1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021875">
        <property type="entry name" value="Dsl1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038442">
        <property type="entry name" value="Dsl1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11989">
        <property type="entry name" value="Dsl1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11988">
        <property type="entry name" value="Dsl1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrograde transport protein Dsl1 N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Retrograde transport protein Dsl1 C-terminal" evidence="3">
        <location>
            <begin position="551"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0133424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="87709" checksum="38B6E68246426FBA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNZ8</accession>
    <name>Q6FNZ8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RAD50</name>
        <name evidence="22 23" type="ordered locus">CAGL0J07788g</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448046.1">
        <property type="nucleotide sequence ID" value="XM_448046.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FNZ8">
        <property type="interactions" value="1108"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNZ8"/>
    <dbReference type="GeneID" id="2889906"/>
    <dbReference type="KEGG" id="cgr:2889906"/>
    <dbReference type="CGD" id="CAL0133732">
        <property type="gene designation" value="RAD50"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07788g"/>
    <dbReference type="eggNOG" id="KOG0962">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006184_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNZ8"/>
    <dbReference type="OMA" id="FSDYYYR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990918">
        <property type="term" value="P:double-strand break repair involved in meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007534">
        <property type="term" value="P:gene conversion at mating-type locus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062176">
        <property type="term" value="P:R-loop processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010520">
        <property type="term" value="P:regulation of reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120290">
        <property type="term" value="P:stalled replication fork localization to nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000593">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001195">
        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04423">
        <property type="entry name" value="Rad50_zn_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14 20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="21">
        <location>
            <begin position="634"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="219"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="397"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="737"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="840"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="966"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="1024"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="681"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="684"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="CGD" id="CAL0133732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="CAG60997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1305" mass="150668" checksum="7489860D317CEF80" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP01</accession>
    <name>Q6FP01_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 75</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J07722g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP01"/>
    <dbReference type="FunCoup" id="Q6FP01">
        <property type="interactions" value="650"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP01"/>
    <dbReference type="KEGG" id="cgr:2889903"/>
    <dbReference type="CGD" id="CAL0132872">
        <property type="gene designation" value="CAGL0J07722g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07722g"/>
    <dbReference type="eggNOG" id="KOG1508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072852_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP01"/>
    <dbReference type="OMA" id="PGKEFPN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070775">
        <property type="term" value="C:H3 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010698">
        <property type="term" value="F:acetyltransferase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0132872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="30859" checksum="EE021F1A16AED072" modified="2004-07-19" version="1">MSDKEIVGKAFLDLAKYEEDVAKVEDDIEHYRLKMMQPMVERRDNIIKNIPEFWKIVLSQHTSFADFIRASDFKYIDLIDKVKVDWLIIEDPKQYSVGDFRITLHFNSIDDDFNEQTVSKVFKLIKGDINEGDTDDETEEERLVSEPVDIQWPKSYDSINPSLIEDKHSKEGKKSYRQGMKSFFGWFKWTGKKPGKEFPHGDSLATLFSEDIYPYCVKYYTEAQRDLEDEEEDDSEDNSSEEPLDLEVESESEESDKKRRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPB0</accession>
    <name>Q6FPB0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J05280g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPB0"/>
    <dbReference type="STRING" id="284593.Q6FPB0"/>
    <dbReference type="KEGG" id="cgr:2889507"/>
    <dbReference type="CGD" id="CAL0132920">
        <property type="gene designation" value="CAGL0J05280g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05280g"/>
    <dbReference type="eggNOG" id="KOG1658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_943339_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPB0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33398" checksum="584690BA3AF56C53" modified="2004-07-19" version="1">MEQPADKPVEMETRNEGAEAVEPAVEAVEAVEVEAAEAAEAAEQKDAEAMNETVDGDTDQGDESRSNAQVIEIEDSDSSPEGDTEMDIDEDQEMKHDDRDETRPTTQSSAKEESRSSSRVVKSEMDESIAQSRREMEELESELGEEARKEKQRVVDELKKQYKLINREYIRRCSRFPISKMRMIAKNDPEYLECTKDALIATAFATELFVQTLTYETLIVNGSVPYGDGNFQQEPKPEPSTPINSDELLLDYKSLSESIALVDHFQFLADIVPRTKNLRELVKENKVRYTATQKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-07-13" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPE6</accession>
    <name>LONM_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PIM1</name>
        <name type="ordered locus">CAGL0J04422g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447898.1">
        <property type="nucleotide sequence ID" value="XM_447898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPE6"/>
    <dbReference type="SMR" id="Q6FPE6"/>
    <dbReference type="FunCoup" id="Q6FPE6">
        <property type="interactions" value="1077"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPE6"/>
    <dbReference type="EnsemblFungi" id="CAGL0J04422g-T">
        <property type="protein sequence ID" value="CAGL0J04422g-T-p1"/>
        <property type="gene ID" value="CAGL0J04422g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889636"/>
    <dbReference type="KEGG" id="cgr:2889636"/>
    <dbReference type="CGD" id="CAL0132864">
        <property type="gene designation" value="CAGL0J04422g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04422g"/>
    <dbReference type="eggNOG" id="KOG2004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FPE6"/>
    <dbReference type="OMA" id="WLTNIPW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901858">
        <property type="term" value="P:regulation of mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000010">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000395776" description="Lon protease homolog, mitochondrial">
        <location>
            <begin position="30"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="3">
        <location>
            <begin position="62"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="815"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="711"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="714"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="907"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="950"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="497"/>
            <end position="504"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1026" mass="114998" checksum="6ECE5E9BA7726BC1" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPL4</accession>
    <name>Q6FPL4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0J02904g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPL4"/>
    <dbReference type="FunCoup" id="Q6FPL4">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPL4"/>
    <dbReference type="CAZy" id="CBM21">
        <property type="family name" value="Carbohydrate-Binding Module Family 21"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889740"/>
    <dbReference type="CGD" id="CAL0133340">
        <property type="gene designation" value="CAGL0J02904g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02904g"/>
    <dbReference type="eggNOG" id="KOG3986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017894_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPL4"/>
    <dbReference type="OMA" id="KSKRFQN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016717">
        <property type="entry name" value="Gip2/Pig2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018234">
        <property type="entry name" value="PPase_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="407"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="543" mass="60487" checksum="AB92398C6DEA5F0E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPL6</accession>
    <name>JHD1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="2">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">JHD1</name>
        <name type="ordered locus">CAGL0J02860g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The JmjC domain mediates the demethylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="2"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447828.1">
        <property type="nucleotide sequence ID" value="XM_447828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPL6"/>
    <dbReference type="SMR" id="Q6FPL6"/>
    <dbReference type="FunCoup" id="Q6FPL6">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPL6"/>
    <dbReference type="EnsemblFungi" id="CAGL0J02860g-T">
        <property type="protein sequence ID" value="CAGL0J02860g-T-p1"/>
        <property type="gene ID" value="CAGL0J02860g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889738"/>
    <dbReference type="KEGG" id="cgr:2889738"/>
    <dbReference type="CGD" id="CAL0133058">
        <property type="gene designation" value="CAGL0J02860g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J02860g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02860g"/>
    <dbReference type="eggNOG" id="KOG1633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003540_6_2_1"/>
    <dbReference type="InParanoid" id="Q6FPL6"/>
    <dbReference type="OMA" id="SQQNERW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0223">Dioxygenase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000226794" description="JmjC domain-containing histone demethylation protein 1">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="141"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P40034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="403" mass="47030" checksum="F327A0D7EB1217BD" modified="2004-07-19" version="1">MAVKIEQALGEKRSLNDNDEVPRKKRYNFRKKVELDYSALNEGEDKKSKFFHPHIALFEKEFEKCLSNVTEDMSMTCSEYCKRFDDIDFPLKISDPENSGMVVSTNNKTTRDLTVDDITQAVGDDYFVNVMDVQSQENERWSLREWCNYFNKPAEEKDRIRNVISLEVSHVEDLQYDRPDIVDDKDLVDIVWNNVENLDTENDPRPKVTKYCLMSVKNAFTDYHLDFAGTSVYYNLAFGKKKFILYPPTPENIENYIEWSTSTYQNMLFLGEKLTGGVAMELNGGDLFMIPSGYIHVVYTPEDSLIFGGNYLTFRDISQQLKIVDVEKQTGVTKRYTFPMFDEVMGRTCEWLCQNQKKGKQMQVKKETVNDLISYMKSGKTKYKPTNFINKKQMLQELSNLYL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPY0</accession>
    <name>LIPA_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="1">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipoate synthase</fullName>
            <shortName evidence="1">LS</shortName>
            <shortName evidence="1">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">CAGL0I10923g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPY0"/>
    <dbReference type="SMR" id="Q6FPY0"/>
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        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPY0"/>
    <dbReference type="KEGG" id="cgr:2889354"/>
    <dbReference type="eggNOG" id="KOG2672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FPY0"/>
    <dbReference type="OMA" id="PYCDIDF"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000398260" description="Lipoyl synthase, mitochondrial">
        <location>
            <begin position="19"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="134"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="388" mass="43401" checksum="457598F13CF7B740" modified="2004-07-19" version="1" precursor="true">MRLTTVQRRFLVSTKAKVSGASISSTANTGSASAGAPNGQTRRRRRITEFKDALNLGPSFEDFVSGRAAGFTVVDPLEQMRQDREEYKKLPKWLKVPIPKGVNYHKLKKDVKELKLSTVCEEARCPNIGECWGGKDKSKATATIMLLGDTCTRGCRFCSVKTNRNPAKPDPTEPENTAEAISRWGLGYVVLTTVDRDDLPDGGAHHLAETVIKIKQKAPKTLVEALTGDFLGNLEMVDVMAKSGLDVYAHNLETVEALTPHVRDRRAGYRQSLNVLKRAKETVPSLITKTSVMLGLGETDDQIIQTMQDLRAINCDVITFGQYMRPTKRHMKVVEYVRPEKFDYWKDKAKEMGFLYCASGPLVRSSYKAGEAFIENVLNKRKQDNKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ65</accession>
    <name>Q6FQ65_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I08789g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ65"/>
    <dbReference type="FunCoup" id="Q6FQ65">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ65"/>
    <dbReference type="KEGG" id="cgr:2888999"/>
    <dbReference type="CGD" id="CAL0132142">
        <property type="gene designation" value="CAGL0I08789g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08789g"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_12_1_1"/>
    <dbReference type="InParanoid" id="Q6FQ65"/>
    <dbReference type="OMA" id="RVQGKFP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF42">
        <property type="entry name" value="TRNA PSEUDOURIDINE(31) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="1">
        <location>
            <begin position="122"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="411" mass="47397" checksum="7BD772420EB8FDD4" modified="2004-07-19" version="1">MSNIQYYYQSGLRKIYPYYHTRTAFVKGRWHNRTVLDVLVKEFRAHSAEYYGHQIVNGKYKLIRDGQYLDNLSVLDTPIKNNDKLESTVHKHEPPVLQWCSNEANIPGKKIAGIDIVYEDENLLVINKPCGIPIHPTGLYYGNTLTEILKVNGVHALPAYRLDKVTSGLLILSKDTGTASMVQKKIRSHEMQKWYLARVEGAFPHVNEVPHIETLEIQRLDLPIEEQIIQDNSILTIEDSDVYTVEPKKQYPSGLSVPRSAKTIFYPIKYFPHKNESIVACRPITGRTHQIRIHLARLNHPIVNDTIYSQKITRYPERLNFIRSIANWSEAKLTDEELSETFQIFIQESEHFKKKALAENKNCPVCSECGALTLSDPDPEDLSIDLHAWRYSDAEKTLNFKTELPQWVVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQA3</accession>
    <name>Q6FQA3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphate metabolism protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0I07865g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQA3"/>
    <dbReference type="FunCoup" id="Q6FQA3">
        <property type="interactions" value="164"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQA3"/>
    <dbReference type="KEGG" id="cgr:2889231"/>
    <dbReference type="CGD" id="CAL0130243">
        <property type="gene designation" value="CAGL0I07865g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07865g"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FQA3"/>
    <dbReference type="OMA" id="NWACVAL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="667"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="12">
        <location>
            <begin position="11"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="13">
        <location>
            <begin position="186"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="10">
        <location>
            <begin position="385"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="11">
        <location>
            <begin position="875"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="755"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="220"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0130243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="974" mass="111149" checksum="783BDE35A9726902" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQD9</accession>
    <name>Q6FQD9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0I07029g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQD9"/>
    <dbReference type="FunCoup" id="Q6FQD9">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQD9"/>
    <dbReference type="KEGG" id="cgr:2889063"/>
    <dbReference type="CGD" id="CAL0132722">
        <property type="gene designation" value="CAGL0I07029g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07029g"/>
    <dbReference type="eggNOG" id="KOG0242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001485_21_2_1"/>
    <dbReference type="InParanoid" id="Q6FQD9"/>
    <dbReference type="OMA" id="CVDDKML"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061673">
        <property type="term" value="C:mitotic spindle astral microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070463">
        <property type="term" value="F:tubulin-dependent ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099606">
        <property type="term" value="P:microtubule plus-end directed mitotic chromosome migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007079">
        <property type="term" value="P:mitotic chromosome movement towards spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031115">
        <property type="term" value="P:negative regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070462">
        <property type="term" value="P:plus-end specific microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032888">
        <property type="term" value="P:regulation of mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000090">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="10"/>
            <end position="443"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
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            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="195"/>
            <end position="202"/>
        </location>
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            <name>ATP</name>
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        </ligand>
    </feature>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023175"/>
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            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0132722"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG60492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="705" mass="80416" checksum="296F6092A63312FF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQE7</accession>
    <name>Q6FQE7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome c oxidase assembly protein COX15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0I06831g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
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            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
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        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="cgr:2889071"/>
    <dbReference type="CGD" id="CAL0132496">
        <property type="gene designation" value="CAGL0I06831g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06831g"/>
    <dbReference type="eggNOG" id="KOG2725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017627_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FQE7"/>
    <dbReference type="OMA" id="AFVCYSW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0132496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG60484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56211" checksum="167F956709051289" modified="2004-07-19" version="1">MLTRQLVRSGQRLLSKNAGILASNGVVGRSTLNSTLNWTGAKHLSQKASSCGILKCVARGRWFSTANNVLRNAAAGARIIDEAALKLDSSGIPLAAKDVKTSKYVAYWLIGTSGLVFGIVILGGLTRLTESGLSITEWKPILGALPPLSQKEWEEEFAKYRESPEFMELNSHINLDEFKFIFFMEWFHRLWGRAIGVIFVMPALYFAATKRTSSHINKRLLFLSGLLGLQGFVGWWMVKSGLDKEQLEIRQSKPTVSQYRLTTHLGAAFFLYMGMMWAGWEILRELKWLKNPARALEAFKKLESPAIIPIRRVAVGLTALTFVTAMSGGMVAGLDAGLLYPTFPHMGEHWIPPKRELFEDRFARKEDKSDMWWRNMLENPVTVQLNHRILATITFTAILVAHIYCNRRKQIVPRNADITMKAMMGVLTCQVTLGALALWYYVPISIASMHQGGALALLTLSLLFTAQLKAPRAPIRSTISKLHAQQLKSGSKVIQEAAKHVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQF1</accession>
    <name>Q6FQF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Plasma membrane iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FTR1</name>
        <name evidence="9 10" type="ordered locus">CAGL0I06743g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447543.1">
        <property type="nucleotide sequence ID" value="XM_447543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQF1"/>
    <dbReference type="FunCoup" id="Q6FQF1">
        <property type="interactions" value="92"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQF1"/>
    <dbReference type="GeneID" id="2889067"/>
    <dbReference type="KEGG" id="cgr:2889067"/>
    <dbReference type="CGD" id="CAL0132388">
        <property type="gene designation" value="FTR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06743g"/>
    <dbReference type="eggNOG" id="ENOG502QQWE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046738_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FQF1"/>
    <dbReference type="OMA" id="SVWHLDC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901684">
        <property type="term" value="P:arsenate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005217">
        <property type="entry name" value="EfeU/FTR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00145">
        <property type="entry name" value="EfeU/Ftr1 family ferrous iron transporter subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0132388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="46100" checksum="E2FE949FDAD7BEB6" modified="2004-07-19" version="1">MPNKVFNVAVFFVVFRECLEAVVIVSILLSFLKQAIGSKDIKLYRKLRKHVWIGVALGFFICLVIGAGFIGAYYSLQKDIFGSTEDLWEGIFCMIATTMISMMGIPMLRINKLQSKWRVKLARSLVDIPKRKRDYFRIGYLTRRYAMFILPFITVLREGLEAVVFVAGAGITTKGSHASAYPLPVVVGLIAGFIVGFLLYYGTSKSSMQIFLVISTSILYLIAAGLFSRGAWYFENYRFNKATGGDASEGGDGNGSYNIAKSVYHVNCCNPELDNGWDIFNALLGWQNTGYLSSILCYNIYWVVLIIVLGLMMHEERYGHLPFMRNVGMRHLNPGYWIKNKKKDELTDEQKAELLNRMDNIQFNEEGDIVAHANEEEHDQESSLLRGNSNKMGSKEELNFKVTTTSSD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2025-06-18" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQI1</accession>
    <name>INO1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Inositol-3-phosphate synthase</fullName>
            <shortName>MIP synthase</shortName>
            <ecNumber evidence="1">5.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Myo-inositol 1-phosphate synthase</fullName>
            <shortName>IPS</shortName>
            <shortName>MI-1-P synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">INO1</name>
        <name type="ordered locus">CAGL0I06050g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (By similarity). Rate-limiting enzyme in the synthesis of all inositol-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text>Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="1"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447513.1">
        <property type="nucleotide sequence ID" value="XM_447513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQI1"/>
    <dbReference type="SMR" id="Q6FQI1"/>
    <dbReference type="FunCoup" id="Q6FQI1">
        <property type="interactions" value="743"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQI1"/>
    <dbReference type="EnsemblFungi" id="CAGL0I06050g-T">
        <property type="protein sequence ID" value="CAGL0I06050g-T-p1"/>
        <property type="gene ID" value="CAGL0I06050g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889369"/>
    <dbReference type="KEGG" id="cgr:2889369"/>
    <dbReference type="CGD" id="CAL0129696">
        <property type="gene designation" value="INO1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I06050g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06050g"/>
    <dbReference type="eggNOG" id="KOG0693">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021486_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FQI1"/>
    <dbReference type="OMA" id="VYVPMKE"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000334">
        <property type="entry name" value="Inositol-3-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0398">Inositol biosynthesis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000195184" description="Inositol-3-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P11986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9NPH2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="538" mass="60271" checksum="FC79F4574C70A328" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQP4</accession>
    <name>Q6FQP4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0I04620g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQP4"/>
    <dbReference type="FunCoup" id="Q6FQP4">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQP4"/>
    <dbReference type="KEGG" id="cgr:2889034"/>
    <dbReference type="CGD" id="CAL0130151">
        <property type="gene designation" value="CAGL0I04620g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04620g"/>
    <dbReference type="eggNOG" id="KOG1505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041844_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FQP4"/>
    <dbReference type="OMA" id="SITKYHE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="107"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0130151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="397" mass="46019" checksum="FD945AF6106EE930" modified="2004-07-19" version="1">MRKEQGQTGFARRTIVPVVSVVSFLSCCVVLLVIQVTAKLRFSQNKTRLTHVYNYTKKQFIVLLTSILRIVAPCEIRVTTDNGSIPKGTFYQDSSSGRLRANLLERSITISNHQIYTDWVFLWWLAYAGDKAGNVFIMLKKSLRKIPVLGYGMENFNFIFMNRKWAYDRVNMSNHLSAIEADSLGCGPISGNKPVKVNSDGEEVWDMKSSAQRNIKWPYNLILFPEGTNLSAHTRKVNEAYAEKIGRVPYRHVLLPRATGLRFCLQKLRNSVDVVYDTTIGYSGILSTEYGQDAYSLKNIFFRGKYPKLVDIHVRSFKLSDIPIDDEIDFIEWLFKVWEEKDKMMEYFYEHGTFENMTDNQESVLVDCSIKNYEFFPVFIIPFCFVLLTYWIVRSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR10</accession>
    <name>Q6FR10_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0I01914g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR10"/>
    <dbReference type="FunCoup" id="Q6FR10">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR10"/>
    <dbReference type="KEGG" id="cgr:2889111"/>
    <dbReference type="CGD" id="CAL0129955">
        <property type="gene designation" value="CAGL0I01914g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01914g"/>
    <dbReference type="HOGENOM" id="CLU_1805921_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR10"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007727">
        <property type="entry name" value="Spo12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05032">
        <property type="entry name" value="Spo12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0129955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="143" mass="15782" checksum="CA9ACFC7E895816C" modified="2004-07-19" version="1">MVTYETKPVMECNEKLLNVSNSKTNTDVVTDIQGLDGSDARYTDTSSLDQSQANIFNISSNKTNQKSNTNFCVGKKTKIGGAGNQTNCMRGKNTDLSLRKKFASPTDHLLSPCSKKLRDHKNSLFGTKGKPLKLKFTDLQSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR15</accession>
    <name>Q6FR15_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0I01804g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR15"/>
    <dbReference type="FunCoup" id="Q6FR15">
        <property type="interactions" value="766"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR15"/>
    <dbReference type="KEGG" id="cgr:2889106"/>
    <dbReference type="CGD" id="CAL0132538">
        <property type="gene designation" value="CAGL0I01804g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01804g"/>
    <dbReference type="eggNOG" id="KOG3254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FR15"/>
    <dbReference type="OMA" id="RERHGLC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000006">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="9">
        <location>
            <begin position="56"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="9">
        <location>
            <begin position="132"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0132538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="216" mass="23414" checksum="A7064B249D18E219" modified="2004-07-19" version="1">MIRTIFGRRAFSVSRAVQSHVGSMPIYVAPEVNVSIGPMSVAKTIRKGRGLLSLAQVISVEGPKGTLKLEVPDFISMEKDKDSGKVTISVKDNESKLQKSMWGTVRSLVNNHIVGVTEGHMAILKFVGTGYGARLENDGKFVNIKVGASIKQGLDVPEGITVKSPSLTSLIIEGSDKQQVLLFAAKLRDFHPPEPYKGKGIYVNGETIKLKAKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR16</accession>
    <name>Q6FR16_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0I01782g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447328.1">
        <property type="nucleotide sequence ID" value="XM_447328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR16"/>
    <dbReference type="STRING" id="284593.Q6FR16"/>
    <dbReference type="KEGG" id="cgr:2889105"/>
    <dbReference type="CGD" id="CAL0129925">
        <property type="gene designation" value="CAGL0I01782g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01782g"/>
    <dbReference type="eggNOG" id="KOG2020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011906_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR16"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0129925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1051" mass="121326" checksum="E6CDCA63FED67E32" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR38</accession>
    <name>Q6FR38_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0I01188g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR38"/>
    <dbReference type="FunCoup" id="Q6FR38">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR38"/>
    <dbReference type="KEGG" id="cgr:2889114"/>
    <dbReference type="CGD" id="CAL0132364">
        <property type="gene designation" value="CAGL0I01188g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01188g"/>
    <dbReference type="eggNOG" id="KOG2655">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017718_8_0_1"/>
    <dbReference type="InParanoid" id="Q6FR38"/>
    <dbReference type="OMA" id="RNRTIMA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000162">
        <property type="entry name" value="septin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="9">
        <location>
            <begin position="21"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0132364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="391" mass="45443" checksum="9D2E0DC017B90DB6" modified="2004-07-19" version="1">MAEVIGLSNLPTQRARIVTQDGGVFNMMVCGESGLGKTTFVNTLFSTTLKSTEDHPRDNAIRKTVRINISRAILEESDFSLRVNVIDTPGFGDNINNDKAWQTVVDFIDDQHDSYMRQEQQPFRDTKFDLRIHAVLYFIRPTGHGLKPIDIETMKRLSSRANLIPIISKSDTLTQNEITEFKNRIRQVLEYHQIRIFTPPLEEAADQSNKQDMISFEHARSIIEAMPFHIVGSDKQYQNAAGQMVTARKYPWGLVEVENEAHCNFVLLRTLLLRTYLADLIETTNEIHYETYRRLRLEVGLKEGEDQRDDDPFIPARAPARKLSHNPAYKQEENALKKYFTDQVKAEEQRFRQWEQNIVTERSKLNSDLEEIQQKVKKMEDQVKNLQLKMR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR48</accession>
    <name>HIR2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein HIR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HIR2</name>
        <name type="ordered locus">CAGL0I00968g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447296.1">
        <property type="nucleotide sequence ID" value="XM_447296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR48"/>
    <dbReference type="SMR" id="Q6FR48"/>
    <dbReference type="FunCoup" id="Q6FR48">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR48"/>
    <dbReference type="EnsemblFungi" id="CAGL0I00968g-T">
        <property type="protein sequence ID" value="CAGL0I00968g-T-p1"/>
        <property type="gene ID" value="CAGL0I00968g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888912"/>
    <dbReference type="KEGG" id="cgr:2888912"/>
    <dbReference type="CGD" id="CAL0129945">
        <property type="gene designation" value="CAGL0I00968g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00968g"/>
    <dbReference type="eggNOG" id="KOG0973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004372_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FR48"/>
    <dbReference type="OMA" id="AWVHHDD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905268">
        <property type="term" value="P:negative regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF1">
        <property type="entry name" value="PROTEIN HIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000286420" description="Protein HIR2">
        <location>
            <begin position="1"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="10"/>
            <end position="48"/>
        </location>
    </feature>
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        </location>
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        <location>
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            <end position="362"/>
        </location>
    </feature>
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        <location>
            <begin position="665"/>
            <end position="706"/>
        </location>
    </feature>
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        <location>
            <begin position="708"/>
            <end position="745"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
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        </location>
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        </location>
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            <end position="567"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR51</accession>
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            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
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                <person name="Richard G.F."/>
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                <person name="Scarpelli C."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
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                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
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                <person name="Babour A."/>
                <person name="Barbe V."/>
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                <person name="Boisrame A."/>
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                <person name="Confanioleri F."/>
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                <person name="Fabre E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <ligand>
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        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0132276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22297" checksum="88F5D7DCE917D882" modified="2004-07-19" version="1">MGLLTIIKKQKLKDREIRCLILGLDNSGKSTIVNGLLPESEKCNSITPTVGFQIHSIVVESAQDGKTYKVNLWDIGGQRTLRPFWDNYFDKTDVLLWCVDIASSLRFDESFNELRELVMQDRDRIGYQCKLVVAINKIDLVEQADLEHYAHDIEQKIEHILHHGQSVGESSIGHYVLCSGKTGAGIENLAQMIVDRE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR62</accession>
    <name>GUF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation factor GUF1, mitochondrial</fullName>
            <ecNumber>3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor 4 homolog</fullName>
            <shortName evidence="1">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">GTPase GUF1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">GUF1</name>
        <name type="ordered locus">CAGL0I00660g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447282.1">
        <property type="nucleotide sequence ID" value="XM_447282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR62"/>
    <dbReference type="SMR" id="Q6FR62"/>
    <dbReference type="FunCoup" id="Q6FR62">
        <property type="interactions" value="760"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR62"/>
    <dbReference type="EnsemblFungi" id="CAGL0I00660g-T">
        <property type="protein sequence ID" value="CAGL0I00660g-T-p1"/>
        <property type="gene ID" value="CAGL0I00660g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889103"/>
    <dbReference type="KEGG" id="cgr:2889103"/>
    <dbReference type="CGD" id="CAL0132114">
        <property type="gene designation" value="CAGL0I00660g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I00660g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00660g"/>
    <dbReference type="eggNOG" id="KOG0462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FR62"/>
    <dbReference type="OMA" id="QVKCDEN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000402880" description="Translation factor GUF1, mitochondrial">
        <location>
            <begin position="22"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="56"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="65"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="132"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="186"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="657" mass="74005" checksum="76B3E7EFD0425146" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRB1</accession>
    <name>Q6FRB1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RFS1</name>
        <name evidence="3" type="synonym">PST2</name>
        <name evidence="3 4" type="ordered locus">CAGL0H10032g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447233.1">
        <property type="nucleotide sequence ID" value="XM_447233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRB1"/>
    <dbReference type="SMR" id="Q6FRB1"/>
    <dbReference type="STRING" id="284593.Q6FRB1"/>
    <dbReference type="GeneID" id="2888755"/>
    <dbReference type="KEGG" id="cgr:2888755"/>
    <dbReference type="CGD" id="CAL0131808">
        <property type="gene designation" value="RFS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10032g"/>
    <dbReference type="eggNOG" id="KOG3135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FRB1"/>
    <dbReference type="OMA" id="SMDEIHG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160020">
        <property type="term" value="P:positive regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="198" mass="21147" checksum="E4186CD9153ED5E2" modified="2004-07-19" version="1">MARVAIIIYSMYGHTAALAEAEKRGVESAGGKADIYQVAETLTAEQLEQFGAPAKATYPIATRDTLEEYDAFLFGVPTRFGNFPQQWKAFWDATGGLWAKGALQGKAAGFFVSTGTGGGNESTVINAISTLAHHGIVYVPLGYKNVFAQITNLQEVHGGSAWGAGTIAGPDGSRQPSELELKTHELQGKYFSETVKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRB6</accession>
    <name>Q6FRB6_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H09922g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRB6"/>
    <dbReference type="STRING" id="284593.Q6FRB6"/>
    <dbReference type="KEGG" id="cgr:2888749"/>
    <dbReference type="CGD" id="CAL0131942">
        <property type="gene designation" value="CAGL0H09922g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09922g"/>
    <dbReference type="HOGENOM" id="CLU_281178_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRB6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1115" mass="125075" checksum="95FD9FE7E30B61E7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRE8</accession>
    <name>Q6FRE8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0H09130g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRE8"/>
    <dbReference type="FunCoup" id="Q6FRE8">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRE8"/>
    <dbReference type="KEGG" id="cgr:2888794"/>
    <dbReference type="CGD" id="CAL0129946">
        <property type="gene designation" value="CAGL0H09130g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09130g"/>
    <dbReference type="eggNOG" id="ENOG502QREF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008074_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRE8"/>
    <dbReference type="OMA" id="PEVYQLQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="514"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0129946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1015" mass="118061" checksum="F32341DA138FA3BB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRN5</accession>
    <name>Q6FRN5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="12 13" type="ordered locus">CAGL0H07183g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447109.1">
        <property type="nucleotide sequence ID" value="XM_447109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRN5"/>
    <dbReference type="FunCoup" id="Q6FRN5">
        <property type="interactions" value="1182"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRN5"/>
    <dbReference type="GeneID" id="2888482"/>
    <dbReference type="KEGG" id="cgr:2888482"/>
    <dbReference type="CGD" id="CAL0130338">
        <property type="gene designation" value="CAGL0H07183g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07183g"/>
    <dbReference type="eggNOG" id="KOG2078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FRN5"/>
    <dbReference type="OMA" id="VGSHSQF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="173"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="302"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="330"/>
            <end position="331"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0130338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="498" mass="57877" checksum="BDFAE6D2E64AB6DE" modified="2004-07-19" version="1">MHRFFSWFPKYRLVRNWSTMSTQHNMYKYSPPVNRSMKELDRSFFTKKIPLVVVKFKDPRNISEFAKNYKESILRIPRIPHVIKLEYKDGHAPSKTVACDNELVTKGVLLTDKITNVQDVSKVLSQGAVDYLNEKQAELLPYEYTLDYNFWKAEEILRSVLPEEFLDEVPTGFTITGHVAHLNLRNEFKPYDSLIGQVILDKNNKIECVVDKVSSIATQFRTFPMKVIAGDSTNLVVEQKESDCTFRFDFSKVYWNSRLHTEHQRLVTDYFKDGEIVCDVFAGVGPFAVPAGKKPSFVLANDLNPESFKYLQENITLNKVSDFVKPFNHDGAEFIKQSANILDNFREESNGVVRHAIKLRGKKRRKGNENEPQPKQLEQQYKEYIIPKNISHYVMNLPDSALTFLGNFNGVYNNIDPEIYKEMPYVHVHCFEKYENGEEVSMEELHKRVFNRILKEMDCSADILPFEAVAFHLVRKVSPTKPMFCCSFKLPKEVAFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRS7</accession>
    <name>Q6FRS7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0H06259g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FRS7">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRS7"/>
    <dbReference type="KEGG" id="cgr:2888836"/>
    <dbReference type="CGD" id="CAL0130462">
        <property type="gene designation" value="CAGL0H06259g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06259g"/>
    <dbReference type="eggNOG" id="KOG1152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004134_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FRS7"/>
    <dbReference type="OMA" id="MDESECR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060917">
        <property type="term" value="P:regulation of (1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="1076"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="639"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="912"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="649"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="912"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="930"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0130462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG60000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1336" mass="149878" checksum="1BFFD9BA81DEFCF1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSD6</accession>
    <name>Q6FSD6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SUR2</name>
        <name evidence="7 8" type="ordered locus">CAGL0H01375g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446858.1">
        <property type="nucleotide sequence ID" value="XM_446858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSD6"/>
    <dbReference type="FunCoup" id="Q6FSD6">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSD6"/>
    <dbReference type="GeneID" id="2888704"/>
    <dbReference type="KEGG" id="cgr:2888704"/>
    <dbReference type="CGD" id="CAL0131468">
        <property type="gene designation" value="SUR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01375g"/>
    <dbReference type="eggNOG" id="KOG0874">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043293_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FSD6"/>
    <dbReference type="OMA" id="FETKPCK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102772">
        <property type="term" value="F:sphingolipid C4-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="158"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0131468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="340" mass="39942" checksum="C0D59C1551017CE4" modified="2004-07-19" version="1">MSVNGTLFEQSFNLKGGYDYMHTVSAPEIKLTPREDLTSYCSDGILALAAPVIAYWAQSAFFHIIDVFHLAEKYRIHPSEEIEKRNRATRLQVLREVIFQHIVQTVVGLIFLKFADESVTGFEQNEMWHWRQQAPGFIPDAAVYYAYMYGVSLIKLSLGFLFIDTWQYFWHRVMHLSPFMYKYFHSIHHELYVPYAYGALFNNPVEGFILDTLGTGIAMFLTGLTHREEAVLFTFATMKTIDDHCGYALPFDPFQIVFPNNAVYHDIHHQQFGLKTNFAQPFFTFWDNLFGTNFKGFEEYQKKQRRVTIDKYKEFLAKREAEKLEKIKNFSKKNENKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSH6</accession>
    <name>Q6FSH6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0H00462g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSH6"/>
    <dbReference type="FunCoup" id="Q6FSH6">
        <property type="interactions" value="1135"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSH6"/>
    <dbReference type="KEGG" id="cgr:2888588"/>
    <dbReference type="CGD" id="CAL0131980">
        <property type="gene designation" value="CAGL0H00462g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00462g"/>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSH6"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="70"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0131980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="225" mass="25153" checksum="B7C61FC4302AC3B2" modified="2004-07-19" version="1">MSDTEAPVEVQEEFEVVEEFTPVTLATPIPEEVQRGSTEIKLFNKWSFEDVEVKDPSLVDYVQIRQPIFVAHTSGRYANKRFRKAQCPIIERLTNSMMMNGRNNGKKLKAVRIIKHTLEIIHILTEQNPLQVVVDAITNTGPREDTTRVGGGGAARRQAVDVSPLRRVNQAIALLTIGAREAAFRNIKTIAETLAEELINAAKGSSTSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSJ9</accession>
    <name>ATG13_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATG13</name>
        <name type="ordered locus">CAGL0G09999g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with ATG1 to form the ATG1-ATG13 kinase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446795.1">
        <property type="nucleotide sequence ID" value="XM_446795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSJ9"/>
    <dbReference type="SMR" id="Q6FSJ9"/>
    <dbReference type="FunCoup" id="Q6FSJ9">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSJ9"/>
    <dbReference type="EnsemblFungi" id="CAGL0G09999g-T">
        <property type="protein sequence ID" value="CAGL0G09999g-T-p1"/>
        <property type="gene ID" value="CAGL0G09999g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888156"/>
    <dbReference type="KEGG" id="cgr:2888156"/>
    <dbReference type="CGD" id="CAL0129383">
        <property type="gene designation" value="CAGL0G09999g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09999g"/>
    <dbReference type="eggNOG" id="KOG4573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_411076_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSJ9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120095">
        <property type="term" value="C:vacuole-isolation membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070016">
        <property type="term" value="F:armadillo repeat domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071255">
        <property type="term" value="P:Cvt vesicle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071211">
        <property type="term" value="P:protein targeting to vacuole involved in autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060341">
        <property type="term" value="P:regulation of cellular localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000157967" description="Autophagy-related protein 13">
        <location>
            <begin position="1"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="315"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="467"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="572"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="321"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="504"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q06628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="660" mass="74347" checksum="348E33C259E4DB11" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSN7</accession>
    <name>Q6FSN7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G09108g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446757.1">
        <property type="nucleotide sequence ID" value="XM_446757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSN7"/>
    <dbReference type="STRING" id="284593.Q6FSN7"/>
    <dbReference type="KEGG" id="cgr:2888042"/>
    <dbReference type="CGD" id="CAL0129764">
        <property type="gene designation" value="CAGL0G09108g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09108g"/>
    <dbReference type="eggNOG" id="KOG2401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801665_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSN7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="93"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="346" mass="38723" checksum="2F008ABF2AF8E0B9" modified="2004-07-19" version="1">MATDMFIKQHNLGYNHAIDPEYQQLRAQAIKSNSVKQHLAAKSLEAIKKGDKHSAKKLITESCIQAERSDRFNLKAAEYAFDQNNANILSNEIDLHGLFAKEAVQVLKKRLVLAAEAGEKKLRVITGKGIHSPGMVCKLQVETLMICHDLNLNFDLDSSNSGVIIINIDRSNFSTSKLDMKDFPFNMTLLKKNMQMQESVSIVESSESTSIPQTTCLKATTPSKVFLEQRTTETINKPTINGSESYSNDNKLNLVRDLTTHHIPKETSECLSNTSTQSSGNAVSEVSSHSNKSTSYQETKVPSYDRTPQYELMPSSIKESNIVFNLFFSCISFSRKEIEITTQNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSX3</accession>
    <name>Q6FSX3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-structural maintenance of chromosome element 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0G07128g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSX3"/>
    <dbReference type="FunCoup" id="Q6FSX3">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSX3"/>
    <dbReference type="KEGG" id="cgr:2888264"/>
    <dbReference type="CGD" id="CAL0130348">
        <property type="gene designation" value="CAGL0G07128g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07128g"/>
    <dbReference type="eggNOG" id="ENOG502QU63">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035923_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSX3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014803">
        <property type="entry name" value="DNA_repair_Nse5/Nse6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08691">
        <property type="entry name" value="Nse5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0130348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="64767" checksum="2B8C6530232218AE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT88</accession>
    <name>TIM16_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial import inner membrane translocase subunit TIM16</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Presequence translocated-associated motor subunit PAM16</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PAM16</name>
        <name type="synonym">TIM16</name>
        <name type="ordered locus">CAGL0G04521g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer with PAM18. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The J-like region, although related to the J domain does not stimulate ATPase activity of mtHSP70. It nevertheless mediates the heterodimerization with the J domain of PAM18 and is therefore essential for PAM complex function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TIM16/PAM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446556.1">
        <property type="nucleotide sequence ID" value="XM_446556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT88"/>
    <dbReference type="SMR" id="Q6FT88"/>
    <dbReference type="FunCoup" id="Q6FT88">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT88"/>
    <dbReference type="EnsemblFungi" id="CAGL0G04521g-T">
        <property type="protein sequence ID" value="CAGL0G04521g-T-p1"/>
        <property type="gene ID" value="CAGL0G04521g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887993"/>
    <dbReference type="KEGG" id="cgr:2887993"/>
    <dbReference type="CGD" id="CAL0130657">
        <property type="gene designation" value="CAGL0G04521g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04521g"/>
    <dbReference type="eggNOG" id="KOG3442">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101461_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FT88"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000006">
        <property type="entry name" value="Import inner membrane translocase subunit TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005341">
        <property type="entry name" value="Tim16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388">
        <property type="entry name" value="MITOCHONDRIA ASSOCIATED GRANULOCYTE MACROPHAGE CSF SIGNALING MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12388:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03656">
        <property type="entry name" value="Pam16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000214090" description="Mitochondrial import inner membrane translocase subunit TIM16">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="J-like">
        <location>
            <begin position="62"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="146" mass="15993" checksum="D179A25347A1F41A" modified="2004-07-19" version="1">MAHRALVKIVITGTRVLGHAFAEAYRQAAAQSAAKQGASAMGRNKTGRGNAAAEYGGITLDESCKILNLDAAKDLKLDKVNQRFDYLFNINDKEKGGSFYLQSKIYRASERLKWELAQREKEAAEEKLPKAEDASEDTGEKSPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTH4</accession>
    <name>Q6FTH4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0G02475g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 60S subunit of the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eL40 is essential for translation of a subset of cellular transcripts, including stress response transcripts, such as DDR2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59397.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTH4"/>
    <dbReference type="FunCoup" id="Q6FTH4">
        <property type="interactions" value="1052"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTH4"/>
    <dbReference type="KEGG" id="cgr:2888345"/>
    <dbReference type="CGD" id="CAL0130452">
        <property type="gene designation" value="CAGL0G02475g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02475g"/>
    <dbReference type="eggNOG" id="KOG0003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010412_3_4_1"/>
    <dbReference type="InParanoid" id="Q6FTH4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="14">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0130452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG59397.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="128" mass="14568" checksum="84BD137A4AB46D27" modified="2008-09-23" version="2">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGIIEPSLKALASKYNCEKSVCRKCYARLPPRATNCRKRKCGHTNQLRPKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTK7</accession>
    <name>Q6FTK7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0G01760g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTK7"/>
    <dbReference type="FunCoup" id="Q6FTK7">
        <property type="interactions" value="864"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTK7"/>
    <dbReference type="KEGG" id="cgr:2888334"/>
    <dbReference type="CGD" id="CAL0137731">
        <property type="gene designation" value="CAGL0G01760g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01760g"/>
    <dbReference type="eggNOG" id="KOG0412">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014853_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FTK7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000425">
        <property type="term" value="P:pexophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000301">
        <property type="term" value="P:retrograde transport, vesicle recycling within Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="10">
        <location>
            <begin position="185"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0137731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="855" mass="98285" checksum="94A83F78FF1BA91D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTQ7</accession>
    <name>Q6FTQ7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Antiviral helicase SLH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0G00506g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FTQ7">
        <property type="interactions" value="682"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTQ7"/>
    <dbReference type="KEGG" id="cgr:2888244"/>
    <dbReference type="CGD" id="CAL0129208">
        <property type="gene designation" value="CAGL0G00506g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00506g"/>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000335_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FTQ7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000241">
        <property type="entry name" value="Antiviral helicase SLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="292"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="516"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1144"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1350"/>
            <end position="1545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1956" mass="222570" checksum="E8AF4E88BF6150B4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="152" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTT1</accession>
    <name>Q6FTT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SKN7</name>
        <name evidence="16 17" type="ordered locus">CAGL0F09097g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the SKN7 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG59287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446363.1">
        <property type="nucleotide sequence ID" value="XM_446363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTT1"/>
    <dbReference type="FunCoup" id="Q6FTT1">
        <property type="interactions" value="946"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTT1"/>
    <dbReference type="GeneID" id="2887693"/>
    <dbReference type="KEGG" id="cgr:2887693"/>
    <dbReference type="CGD" id="CAL0130876">
        <property type="gene designation" value="SKN7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F09097g"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008776_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FTT1"/>
    <dbReference type="OMA" id="TNVDPGW"/>
    <dbReference type="PHI-base" id="PHI:2566"/>
    <dbReference type="PHI-base" id="PHI:9717"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900101">
        <property type="term" value="P:regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000304">
        <property type="term" value="P:response to singlet oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014402">
        <property type="entry name" value="Sig_transdc_resp-reg_Skn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002595">
        <property type="entry name" value="RR_SKN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="406"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="531"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="550"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR002595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0130876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG59287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="630" mass="70023" checksum="A5A8153E171727BA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTV5</accession>
    <name>Q6FTV5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor methyltransferase 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAGL0F08525g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTV5"/>
    <dbReference type="FunCoup" id="Q6FTV5">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTV5"/>
    <dbReference type="KEGG" id="cgr:2887704"/>
    <dbReference type="eggNOG" id="KOG3350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074410_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FTV5"/>
    <dbReference type="OMA" id="CNFRPEH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019369">
        <property type="entry name" value="Efm5/EEF1AKMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13200:SF0">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="22094" checksum="9884C91B7541CF37" modified="2004-07-19" version="1">MNLFKEDWQLSQFWYSDSTADKLADALLEGADATTVIAIVSAPSVYAAIQKRDDSEIPTKHIYLFEYDTRFELLAGKDHFFFYDYNKPLDFDDKLKGKVDRLLIDPPFLNEDCQSKSAQTAKSLLAPKDGSKTSDGLLKHRLISCTGERMAQVIKKAYPDTEITDFYPEHGNGLSNEFRCYANFEWSGWKFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTZ1</accession>
    <name>Q6FTZ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0F07711g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTZ1"/>
    <dbReference type="FunCoup" id="Q6FTZ1">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887928"/>
    <dbReference type="CGD" id="CAL0130996">
        <property type="gene designation" value="CAGL0F07711g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07711g"/>
    <dbReference type="eggNOG" id="KOG0770">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FTZ1"/>
    <dbReference type="OMA" id="FFGVYEF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990616">
        <property type="term" value="P:magnesium ion export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000095">
        <property type="entry name" value="Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000125">
        <property type="entry name" value="YMR166C-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="51"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="146"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="254"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0130996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG59227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="40990" checksum="D0128B7948D4932B" modified="2004-07-19" version="1">MWSFTSSIPVFGTVHDTDGHGHDIPTTSGGSGPSSSRSGDDQNLFDDYEHSPIWHCFLAGGVGGIIGDSAMHSLDTVKTRQQGAPNVHKYKHMLQAYRTMFIEEGFRRGLYGGYCAAMLGSFPSAAIFFSTYEFTKRTMINDYHLNDTFSHLTAGFLGDFFSSFVYVPSEVLKTRLQLQGCYNNPHFNSGYNYKSLRNAIATIYRTEGVAALFFGYKATLARDLPFSALQFAFYEKFRQWAFLLEGKDIYKHDLSISNEIVTGACAGGLAGILTTPLDVVKTRVQTQLPSQIDISTDTKIKNVSKPVTLTNSIFKSLRTVYTSEGFFGFFSGVGPRFVWTSVQSSIMLLLYQMALRVLSNRESEKLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU36</accession>
    <name>Q6FU36_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Guanine nucleotide-binding protein alpha-1 subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GP1-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GPA1</name>
        <name evidence="16 17" type="ordered locus">CAGL0F06677g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
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                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
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                <person name="Goffard N."/>
                <person name="Frangeul L."/>
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                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
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                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
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                <person name="Scarpelli C."/>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
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                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
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                <person name="Scarpelli C."/>
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                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
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        <text evidence="1">Involved in cation homeostasis and in the regulation of the cation stress signaling cascades.</text>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000076236" description="Protein ATC1/LIC4">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="348" mass="39788" checksum="F307441D7D0D59E6" modified="2004-07-19" version="1">MKAQSSQEQEDGLTMLHRILKDDNVDMDSALSDMEGPSVNQNLDKLEIDYRNQFEIAYRENSFENLEELSDETIGKHVTLDTLLKMDNDVIFKDENIFDDEDRSSRKRQRDSVSDTDTLFNEQTDSKKRKDSDMDSCKNAIDSIMTEQILSPISLSPTPSSDGSIQNDKTESLEIAKDLPKEPRKPVDKPARAKLKNKYEMSNIIIHKEDIPAANLRNRRSMVDNNVIKKISPHSSADHNKTVKKEPVVITNEYTVSQVAQMKRRIIDSHKLLLNFNVIKDNYARACVQLKRSVTALKDSEIHRAHLILENEELKKQLQALQQHSTGKEEANSTNIPKQNILKNEADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU77</accession>
    <name>Q6FU77_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SLY1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0F05665g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU77"/>
    <dbReference type="FunCoup" id="Q6FU77">
        <property type="interactions" value="1281"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU77"/>
    <dbReference type="KEGG" id="cgr:2887652"/>
    <dbReference type="CGD" id="CAL0131094">
        <property type="gene designation" value="CAGL0F05665g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05665g"/>
    <dbReference type="eggNOG" id="KOG1301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016216_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FU77"/>
    <dbReference type="OMA" id="VNDLRAW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035543">
        <property type="term" value="P:positive regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="75437" checksum="CE8971A28A92CA90" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUS8</accession>
    <name>Q6FUS8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Endonuclease III homolog</fullName>
            <ecNumber evidence="12">3.2.2.-</ecNumber>
            <ecNumber evidence="12">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="12">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NTG1</name>
        <name evidence="14 15" type="ordered locus">CAGL0F00979g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="12"/>
    <dbReference type="EC" id="4.2.99.18" evidence="12"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUS8"/>
    <dbReference type="FunCoup" id="Q6FUS8">
        <property type="interactions" value="382"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUS8"/>
    <dbReference type="KEGG" id="cgr:2887709"/>
    <dbReference type="CGD" id="CAL0131104">
        <property type="gene designation" value="CAGL0F00979g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00979g"/>
    <dbReference type="eggNOG" id="KOG1921">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_4_3_1"/>
    <dbReference type="InParanoid" id="Q6FUS8"/>
    <dbReference type="OMA" id="RGKRCDL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000001">
        <property type="entry name" value="Endonuclease III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000021">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="159"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0131104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="392" mass="45625" checksum="21019F433D8F1164" modified="2004-07-19" version="1">MVPRKRTRRYLEVDVEGNPAEGVVQSKYFKKEETVTVKHEPVSDYKDFVDEVDIEWIKSLDTQAFFDYIDDRTSEDPQRWLKPLDEDSLGLKPLEIAKLPKSFIPIYNRVRLMRAQLKTPVDKVGCALMPIFIAENCGLHKEQILPKNYRFQLLIAVMLSSQTKDEITAEAMLNIMRYCLNELHDPNGMTLESVLMMDESIIDEKIKSVGFHRRKATYIYKSVRMLRDNFDSDVPTNVNDMLSLPGVGPKMTYLALQRAWGKMDGICVDVHVDRLCKMWRWVDAKKCKTPDHTRKALQTWLPKCLWYEINTVLVGFGQVICMARGKRCDICLANDICNARDRKLLSKLQFEEDIDEAFWKLSKTTRGNFDEYILYLKKKLKSDKYPIKAEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUY3</accession>
    <name>Q6FUY3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcipressin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RCN1</name>
        <name evidence="2 3" type="ordered locus">CAGL0E06248g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445961.1">
        <property type="nucleotide sequence ID" value="XM_445961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUY3"/>
    <dbReference type="FunCoup" id="Q6FUY3">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUY3"/>
    <dbReference type="GeneID" id="2887348"/>
    <dbReference type="KEGG" id="cgr:2887348"/>
    <dbReference type="CGD" id="CAL0128980">
        <property type="gene designation" value="RCN1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06248g"/>
    <dbReference type="eggNOG" id="KOG4019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1390040_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUY3"/>
    <dbReference type="OMA" id="MPPRSIF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030346">
        <property type="term" value="F:protein phosphatase 2B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21889" checksum="AA03706980D66EB2" modified="2004-07-19" version="1">MDSLVTDTIILTSNERDITGQEILPILASWFEDNVLSNIQVLPANPIQLLLLKNFKRCLIICPDHAVSNAVMQKLKLKVPLPDLIFNYSITDSQNNSSVKKDYLKVPEHQRLFLISPPSSPPPEFDYSKCEDKPSFKTHAHQPEKILRQATSFVAIESQVGTITVNTCDDYNNGGPGLEGVRTALPPKSIFDDIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV24</accession>
    <name>Q6FV24_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">DNA polymerase gamma</fullName>
            <ecNumber evidence="4 15">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0E05324g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Involved in the replication of mitochondrial DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4 15"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FV24">
        <property type="interactions" value="825"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV24"/>
    <dbReference type="KEGG" id="cgr:2887284"/>
    <dbReference type="CGD" id="CAL0128678">
        <property type="gene designation" value="CAGL0E05324g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05324g"/>
    <dbReference type="eggNOG" id="KOG3657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001524_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FV24"/>
    <dbReference type="OMA" id="AMHITNL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032043">
        <property type="term" value="P:mitochondrial DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000035">
        <property type="entry name" value="DNA polymerase gamma, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000797">
        <property type="entry name" value="DNA_pol_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 15" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="17">
        <location>
            <begin position="700"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1241"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0128678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG58839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1284" mass="146466" checksum="1FEAAE46148B5A4C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV95</accession>
    <name>Q6FV95_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAGL0E03740g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV95"/>
    <dbReference type="FunCoup" id="Q6FV95">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV95"/>
    <dbReference type="KEGG" id="cgr:2887412"/>
    <dbReference type="eggNOG" id="ENOG502S4IY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_959744_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FV95"/>
    <dbReference type="OMA" id="FPHTMSG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018852">
        <property type="entry name" value="DUF2456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10445">
        <property type="entry name" value="DUF2456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="290" mass="33990" checksum="F6E129D356178D37" modified="2004-07-19" version="1">MYHGVKEKITLWRFPHTMSGDCALTVFIQVCVTWVAEELFIGWDDYLGTCGHIPWPWKIPQNKWVRLFFEVDRGMRRMYAEWLDWSQEAAVVLDDEKNGPPGTVTPQHTSQMVAHPIQQEPNDESTANDSENPDEHRNKEDRMSFEDTSSKDHLNPQTGFKPLTFKEYLLKQFIHYDNHGFMWNFIEWAIQKVIRGLILSAIIWFFVWPVTMGILAGIGTKIGSHEYYFNHYPFPQVMKMIYGVVIGLISTPATIIVIMLRNDWHEADYQERELRKDLENEADTSKSDEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVE6</accession>
    <name>PFA4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Palmitoyltransferase PFA4</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein S-acyltransferase</fullName>
            <shortName evidence="1">PAT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein fatty acyltransferase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PFA4</name>
        <name type="ordered locus">CAGL0E02497g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="1"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445798.1">
        <property type="nucleotide sequence ID" value="XM_445798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVE6"/>
    <dbReference type="FunCoup" id="Q6FVE6">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVE6"/>
    <dbReference type="EnsemblFungi" id="CAGL0E02497g-T">
        <property type="protein sequence ID" value="CAGL0E02497g-T-p1"/>
        <property type="gene ID" value="CAGL0E02497g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887488"/>
    <dbReference type="KEGG" id="cgr:2887488"/>
    <dbReference type="CGD" id="CAL0129088">
        <property type="gene designation" value="CAGL0E02497g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02497g"/>
    <dbReference type="eggNOG" id="KOG1314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027721_8_0_1"/>
    <dbReference type="InParanoid" id="Q6FVE6"/>
    <dbReference type="OMA" id="TMNCVGY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03199">
        <property type="entry name" value="DHHC_PAT_PFA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033682">
        <property type="entry name" value="PFA4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000212963" description="Palmitoyltransferase PFA4">
        <location>
            <begin position="1"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="62"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="185"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="2">
        <location>
            <begin position="78"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00067"/>
        </source>
    </evidence>
    <sequence length="376" mass="44136" checksum="62AF69C23C5AAF33" modified="2004-07-19" version="1">MPVKLKWPWLGIAIPSFLIASIGYCAHYFILLNFLSLRKQLWYQFCQTMIWLSYYLAIYTPPGKPPTNFKPSKNEWKVYCKKCKCYKPERSHHCKTCNQCVLMMDHHCPWTMNCVGYNNFPHFIRFLFWVIVGTTSLAIFLTTRIHSIWVHRSSPSYLYYKSELIFLTILTPLNAFILLTISILMIRCLFNQIFNGRSQIESWEMDRLETLARMSKLLPILIENVWYIFPNLRNEHVESQAEALLNKKRLSLDELVNFPYDLGPFRNAIQLLGTPPLWLYPFSGPQDDGLHFQKNEESMIEDPNSLNDIILCLPWPPDSTKHLNSTSEHTSNVQIISEEGEQVIRIRTPEKKLSRSEWLNDWGESLEDFGVDVDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVG4</accession>
    <name>Q6FVG4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription activator GCR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0E02079g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVG4"/>
    <dbReference type="FunCoup" id="Q6FVG4">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVG4"/>
    <dbReference type="KEGG" id="cgr:2887399"/>
    <dbReference type="CGD" id="CAL0129116">
        <property type="gene designation" value="CAGL0E02079g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02079g"/>
    <dbReference type="eggNOG" id="ENOG502RNWJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030906_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVG4"/>
    <dbReference type="OMA" id="QPIGWLC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071475">
        <property type="term" value="P:cellular hyperosmotic salinity response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097238">
        <property type="term" value="P:cellular response to methylglyoxal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000219">
        <property type="term" value="P:positive regulation of invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000222">
        <property type="term" value="P:positive regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060963">
        <property type="term" value="P:positive regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000883">
        <property type="term" value="P:positive regulation of starch catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052146">
        <property type="entry name" value="HOT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022210">
        <property type="entry name" value="TF_GCR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37784:SF8">
        <property type="entry name" value="PROTEIN MSN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12550">
        <property type="entry name" value="GCR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription activator GCR1-like" evidence="2">
        <location>
            <begin position="358"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="462" mass="51356" checksum="6277CA9BB47C793F" modified="2004-07-19" version="1">MNREGISGPGGAIITHDSVSTGSSSNSKNNGGNNNNSNIPNGNSSMGDDIMVLSRINDIERRMMMFENMFHALSGRLDHHFKKYDVLVSSQQQQISELNAVITTLLNDQYRHAEFVRDKLSHSLHGISSTSISLNGISNQNNDNRSNGFANNNSSGVASGSSNGVNSQGNTNNNSNRSSSTSHLNNPNMLGNNSSGTGNNHNNNSVGASNSNQSVTHTILDDILNEHDLQDKKYSGNRNPGDMNSRNDVNDKSQQSPRDPMSLKKTKFIHHRQYNDVTDGDSVIPYTNPYVDQSGHQQNNLTSNILFNDSTSGQNAGNQGTQQATQNREEGMPSSPGRKSYSSKRGPKKKKVMYHKPFQFIKSPHSVMEIWKEYTEGIDGQPSIREMESLYSTGWRRDAAVNKRYSRRKVLWKAIETGLSRGYTLDYIIDLLENYRIIDPEKNTKQPIGWLCQVNNIPDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVL3</accession>
    <name>Q6FVL3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein SEC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0E01001g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVL3"/>
    <dbReference type="FunCoup" id="Q6FVL3">
        <property type="interactions" value="882"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVL3"/>
    <dbReference type="KEGG" id="cgr:2887361"/>
    <dbReference type="CGD" id="CAL0128562">
        <property type="gene designation" value="CAGL0E01001g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01001g"/>
    <dbReference type="eggNOG" id="KOG1300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009210_1_0_1"/>
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        <property type="component" value="Chromosome E"/>
    </dbReference>
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        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:cellular bud tip"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031340">
        <property type="term" value="P:positive regulation of vesicle fusion"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
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        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
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        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="651"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="680"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="80753" checksum="F0E76320370FAD69" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVR7</accession>
    <name>Q6FVR7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zonadhesin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0D06226g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445677.1">
        <property type="nucleotide sequence ID" value="XM_445677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVR7"/>
    <dbReference type="KEGG" id="cgr:2887004"/>
    <dbReference type="CGD" id="CAL0128157">
        <property type="gene designation" value="CAGL0D06226g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D06226g"/>
    <dbReference type="HOGENOM" id="CLU_360545_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVR7"/>
    <dbReference type="OMA" id="TITTRIC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273553" description="Zonadhesin" evidence="2">
        <location>
            <begin position="22"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="84776" checksum="C79D5126FEB3110A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW47</accession>
    <name>Q6FW47_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCT-theta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CCT8</name>
        <name evidence="9 10" type="ordered locus">CAGL0D03014g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445547.1">
        <property type="nucleotide sequence ID" value="XM_445547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW47"/>
    <dbReference type="FunCoup" id="Q6FW47">
        <property type="interactions" value="1727"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW47"/>
    <dbReference type="GeneID" id="2887246"/>
    <dbReference type="KEGG" id="cgr:2887246"/>
    <dbReference type="CGD" id="CAL0128483">
        <property type="gene designation" value="CCT8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03014g"/>
    <dbReference type="eggNOG" id="KOG0362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FW47"/>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0128483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="565" mass="61037" checksum="5C7AE12FD528C59C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW95</accession>
    <name>Q6FW95_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase cytochrome B subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0D01958g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW95"/>
    <dbReference type="FunCoup" id="Q6FW95">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW95"/>
    <dbReference type="KEGG" id="cgr:2887163"/>
    <dbReference type="CGD" id="CAL0128155">
        <property type="gene designation" value="CAGL0D01958g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01958g"/>
    <dbReference type="eggNOG" id="KOG0449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094691_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW95"/>
    <dbReference type="OMA" id="MNGIRHL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01000">
        <property type="entry name" value="SDH_CYT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0128155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20646" checksum="849B49C33239E922" modified="2004-07-19" version="1">MLSLGLMNRSAGCTRRAVLLIRGAAQRRLLSSSVRRLNTMKSSMNAEEEALLNKQRALRPISPHLTIYQPQLTWYMSSVHRISHLILGGTFYVLTILFGLGYFVSGINTESVSQWYHKHVSPMTEQIVKAGFAFTFAFHYFSTIRHYIWDFAKELTLKGVYRTGYSVLALTAIAGTYIWNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWG6</accession>
    <name>Q6FWG6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PXA2</name>
        <name evidence="11 12" type="ordered locus">CAGL0D00352g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445428.1">
        <property type="nucleotide sequence ID" value="XM_445428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWG6"/>
    <dbReference type="FunCoup" id="Q6FWG6">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWG6"/>
    <dbReference type="GeneID" id="2886972"/>
    <dbReference type="KEGG" id="cgr:2886972"/>
    <dbReference type="CGD" id="CAL0128185">
        <property type="gene designation" value="PXA2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00352g"/>
    <dbReference type="eggNOG" id="KOG0064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007587_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FWG6"/>
    <dbReference type="OMA" id="CHRTSLW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015916">
        <property type="term" value="P:fatty-acyl-CoA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042758">
        <property type="term" value="P:long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="497"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="821"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0128185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="861" mass="97239" checksum="7533E649371945B1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWV1</accession>
    <name>ART10_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Arrestin-related trafficking adapter 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ART10</name>
        <name type="ordered locus">CAGL0C02673g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ART10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445293.1">
        <property type="nucleotide sequence ID" value="XM_445293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWV1"/>
    <dbReference type="FunCoup" id="Q6FWV1">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWV1"/>
    <dbReference type="EnsemblFungi" id="CAGL0C02673g-T">
        <property type="protein sequence ID" value="CAGL0C02673g-T-p1"/>
        <property type="gene ID" value="CAGL0C02673g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886915"/>
    <dbReference type="KEGG" id="cgr:2886915"/>
    <dbReference type="CGD" id="CAL0127230">
        <property type="gene designation" value="CAGL0C02673g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_C02673g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02673g"/>
    <dbReference type="eggNOG" id="ENOG502QWIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_540776_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWV1"/>
    <dbReference type="OMA" id="YSFKTCT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0254">Endocytosis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000402192" description="Arrestin-related trafficking adapter 10">
        <location>
            <begin position="1"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="504" mass="58398" checksum="4122E0E76A460663" modified="2004-07-19" version="1">MAPKLDIILHPPENGEFYSSDDLISGTIVLDLTKSLSIKQIKVGLKGFTETTTKMDSEYVFPQNGMLGPATENKSYHNLVREERRVFPPDNVWDALEGSSKPFKVKPGHYEYMFQFNKLPSKPMCLKNHTKKTICFVSKSQSTMPPSFNTQWRELNKIDNLDLYFYSFGKIIYVVEVEIEMGRPRTWFKPFDKMLREPKIIEFIPEPKKFASNETVTRSGRNNHGVIDYISKNNSSKSLSAMQESEDGVTAIAPNGPDEKFLARNLDQLDINNDLEYEIEETEENPMKRYKCRYPLGLPDGASMMWVEVRSRDIDTIYRQDFLFRQGSGNFDNVYLIVKGNLSFSDFSNISVKPTRLQLNLLETVSYLSQGIGNENFSSLKLMEIDNLSKSDRPLFDTNELKFISSKNHEIMECEIKLKDNPILKRLQFNEEDYKHRGNRLYSFKTCVITRLFSYQLLIDWNINGQTRQTETIIPVQVFAHKRPPPVNEALPRYVEPPSYDDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWZ3</accession>
    <name>Q6FWZ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5'-deoxynucleotidase</fullName>
            <ecNumber evidence="8">3.1.3.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0C01749g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'-deoxyribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18274"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.1.3.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HDDC2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.89" evidence="8"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445251.1">
        <property type="nucleotide sequence ID" value="XM_445251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWZ3"/>
    <dbReference type="FunCoup" id="Q6FWZ3">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWZ3"/>
    <dbReference type="KEGG" id="cgr:2886922"/>
    <dbReference type="CGD" id="CAL0127512">
        <property type="gene designation" value="CAGL0C01749g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C01749g"/>
    <dbReference type="eggNOG" id="KOG3197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039453_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FWZ3"/>
    <dbReference type="OMA" id="PFFHMLE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002953">
        <property type="term" value="F:5'-deoxynucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009159">
        <property type="term" value="P:deoxyribonucleoside monophosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000011">
        <property type="entry name" value="HD domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039356">
        <property type="entry name" value="YfbR/HDDC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11845:SF13">
        <property type="entry name" value="5'-DEOXYNUCLEOTIDASE HDDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13023">
        <property type="entry name" value="HD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="13">
        <location>
            <begin position="77"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0127512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="235" mass="27662" checksum="8D5E0DC7C41AADC9" modified="2004-07-19" version="1">MRQMSNTRTVSQEVVNGDIKLSTKIWAPEDYIPQDVKNMLAEDTPNYMLSFMKVLEQLKVQRRTGWLDHGMTKCESIADHMYRMGIISMLIKNKEVSKDQCVKIALIHDMAESLVGDITPVDPIGKEEKHRREMETINYISETLIKPFNEEAAEEIKSLWYSYENITSLEARYVKDIDKYELLVQCFEYEKQHKAKLNFQSFFQAAEWVKTDEVKEWVNDLIARRNRFFASLEKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX42</accession>
    <name>ATR_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Serine/threonine-protein kinase MEC1</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>ATR homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>DNA-damage checkpoint kinase MEC1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Mitosis entry checkpoint protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MEC1</name>
        <name type="ordered locus">CAGL0C00473g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <text evidence="1">Localizes to nuclear DNA repair foci in response to DNA double strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445202.1">
        <property type="nucleotide sequence ID" value="XM_445202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX42"/>
    <dbReference type="SMR" id="Q6FX42"/>
    <dbReference type="FunCoup" id="Q6FX42">
        <property type="interactions" value="1335"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX42"/>
    <dbReference type="EnsemblFungi" id="CAGL0C00473g-T">
        <property type="protein sequence ID" value="CAGL0C00473g-T-p1"/>
        <property type="gene ID" value="CAGL0C00473g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886754"/>
    <dbReference type="KEGG" id="cgr:2886754"/>
    <dbReference type="CGD" id="CAL0127418">
        <property type="gene designation" value="CAGL0C00473g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00473g"/>
    <dbReference type="eggNOG" id="KOG0890">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000178_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FX42"/>
    <dbReference type="OMA" id="SMYIGWC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070310">
        <property type="term" value="C:ATR-ATRIP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000105">
        <property type="term" value="P:positive regulation of DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000033">
        <property type="entry name" value="Serine/threonine-protein kinase MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058681">
        <property type="entry name" value="HEAT_MEC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012993">
        <property type="entry name" value="UME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF125">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MEC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25385">
        <property type="entry name" value="HEAT_MEC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08064">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00802">
        <property type="entry name" value="UME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000227710" description="Serine/threonine-protein kinase MEC1">
        <location>
            <begin position="1"/>
            <end position="2379"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="3">
        <location>
            <begin position="1410"/>
            <end position="1955"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="2">
        <location>
            <begin position="2060"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="3 4">
        <location>
            <begin position="2347"/>
            <end position="2379"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-loop" evidence="2">
        <location>
            <begin position="2066"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic loop" evidence="2">
        <location>
            <begin position="2232"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Activation loop" evidence="2">
        <location>
            <begin position="2252"/>
            <end position="2276"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="2379" mass="275686" checksum="3C0ED0CD6DB7F88E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX72</accession>
    <name>Q6FX72_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-serine dehydratase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0B00286g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX72"/>
    <dbReference type="FunCoup" id="Q6FX72">
        <property type="interactions" value="541"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX72"/>
    <dbReference type="KEGG" id="cgr:2886664"/>
    <dbReference type="CGD" id="CAL0127052">
        <property type="gene designation" value="CAGL0B00286g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B00286g"/>
    <dbReference type="eggNOG" id="KOG1250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FX72"/>
    <dbReference type="OMA" id="AEQGCEH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06448">
        <property type="entry name" value="L-Ser-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000068">
        <property type="entry name" value="Catabolic L-serine/threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="5"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0127052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG57882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="360" mass="39372" checksum="CA56E61DE5F368DF" modified="2004-07-19" version="1">MSVYNKTPLIRQIFPSIPQMYLKHECFQPSGSFKSRGIGHLISKQSQRILGNGLGKKPMVFASSGGNAGLAAATAAKFLNLPCTVVIPTATKQRMADKIRATGANVIVSGNFWKEADNYLKDNILSKLEELHKNVEPIYVHPFDNPDIWEGHASMVDEIVEDFKNKMIPLNKIKAIVCSVGGGGLYNGIIQGLEKYNLADKIPIVGVETKGCHVFNTSLRMNKVVSFKKITSIATSLGTADISTEAFKYAKRYGTKSVVLSDQDVVKTCLRYTHDFNMVIEPACGAAVHLAYHTEILEKELGTKLNADDIVLVVACGGSSNTVEDMESILQRLSTEENNINIPNVAENIIVRMPEVSVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXH4</accession>
    <name>Q6FXH4_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BMT2</name>
        <name evidence="6 7" type="ordered locus">CAGL0B02882g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BMT family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445097.1">
        <property type="nucleotide sequence ID" value="XM_445097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXH4"/>
    <dbReference type="STRING" id="284593.Q6FXH4"/>
    <dbReference type="CAZy" id="GT91">
        <property type="family name" value="Glycosyltransferase Family 91"/>
    </dbReference>
    <dbReference type="GeneID" id="2886514"/>
    <dbReference type="KEGG" id="cgr:2886514"/>
    <dbReference type="CGD" id="CAL0127672">
        <property type="gene designation" value="BMT2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B02882g"/>
    <dbReference type="eggNOG" id="ENOG502QTZG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013841_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXH4"/>
    <dbReference type="OMA" id="VYIVYQW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021988">
        <property type="entry name" value="BMT1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12141">
        <property type="entry name" value="BMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0127672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG57997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="616" mass="71232" checksum="90A534CF70C6E9D5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXJ4</accession>
    <name>Q6FXJ4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0B03443g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXJ4"/>
    <dbReference type="FunCoup" id="Q6FXJ4">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXJ4"/>
    <dbReference type="KEGG" id="cgr:2886508"/>
    <dbReference type="CGD" id="CAL0127838">
        <property type="gene designation" value="CAGL0B03443g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03443g"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_2_5_1"/>
    <dbReference type="InParanoid" id="Q6FXJ4"/>
    <dbReference type="OMA" id="KVQYPWI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="1">
        <location>
            <begin position="146"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="585" mass="67256" checksum="9C80F04DFA3CC8FA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXJ8</accession>
    <name>DPB3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>DNA polymerase epsilon subunit C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>DNA polymerase II subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DPB3</name>
        <name type="ordered locus">CAGL0B03355g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3 and DPB4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445117.1">
        <property type="nucleotide sequence ID" value="XM_445117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXJ8"/>
    <dbReference type="SMR" id="Q6FXJ8"/>
    <dbReference type="FunCoup" id="Q6FXJ8">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXJ8"/>
    <dbReference type="EnsemblFungi" id="CAGL0B03355g-T">
        <property type="protein sequence ID" value="CAGL0B03355g-T-p1"/>
        <property type="gene ID" value="CAGL0B03355g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886501"/>
    <dbReference type="KEGG" id="cgr:2886501"/>
    <dbReference type="CGD" id="CAL0127826">
        <property type="gene designation" value="CAGL0B03355g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03355g"/>
    <dbReference type="eggNOG" id="KOG1658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1089889_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXJ8"/>
    <dbReference type="OMA" id="SNAAFMA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22929">
        <property type="entry name" value="HFD_POLE4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000208345" description="DNA polymerase epsilon subunit C">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="109"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P27344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="255" mass="28353" checksum="E1A115813EB10909" modified="2004-07-19" version="1">MSMSEEEKMVLQQKIRDRTPKLPISKVKRIGKVDPESILTSNMAYVATAFATELFVQSFVEQALFGAQLRRGKKKAGLRLTNDALVECVRNRDDYIFLEDVVRHIEKPKTSSGLHKLSAKPVGQGQEAEQKDASMEEDIPEEDLQEDDEMDVDETEPAERPAASKASDVNKASASAKSILSAFKYAPESAPQIHGSTQTEEDEGDEKEEDEDEEEEIDPEVQTQLQEVEKMNVVADLDEESEVSSDEDEASADDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXK6</accession>
    <name>Q6FXK6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein Dnt1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0B03179g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445109.1">
        <property type="nucleotide sequence ID" value="XM_445109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXK6"/>
    <dbReference type="STRING" id="284593.Q6FXK6"/>
    <dbReference type="KEGG" id="cgr:2886577"/>
    <dbReference type="CGD" id="CAL0127062">
        <property type="gene designation" value="CAGL0B03179g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03179g"/>
    <dbReference type="eggNOG" id="ENOG502QW4V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_315203_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXK6"/>
    <dbReference type="OMA" id="HEYPDES"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018844">
        <property type="entry name" value="Dnt1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043185">
        <property type="entry name" value="Net1/Tof2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28196">
        <property type="entry name" value="NUCLEOLAR PROTEIN NET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28196:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN NET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10407">
        <property type="entry name" value="Cytokin_check_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein Dnt1-like N-terminal" evidence="2">
        <location>
            <begin position="46"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="506"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="544"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="575"/>
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    </feature>
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        <location>
            <begin position="721"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="791"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="866"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="915"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="927" mass="101991" checksum="654355F0EF6BECAE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXR1</accession>
    <name>Q6FXR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0B03773g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="CGD" id="CAL0127162">
        <property type="gene designation" value="CAGL0B03773g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03773g"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_12_0_1"/>
    <dbReference type="InParanoid" id="Q6FXR1"/>
    <dbReference type="OMA" id="FCWFAIN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005291">
        <property type="term" value="F:high-affinity L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015817">
        <property type="term" value="P:histidine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006828">
        <property type="term" value="P:manganese ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000074">
        <property type="entry name" value="Histidine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF13">
        <property type="entry name" value="HISTIDINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="96"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0127162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="605" mass="65845" checksum="F55A712CF2BEF32A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-10-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXR9</accession>
    <name>GATB_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial</fullName>
            <shortName evidence="1">Glu-AdT subunit B</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PET112</name>
        <name type="ordered locus">CAGL0A04653g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This protein may be expected to contain an N-terminal transit peptide but none has been predicted.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444970.1">
        <property type="nucleotide sequence ID" value="XM_444970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXR9"/>
    <dbReference type="SMR" id="Q6FXR9"/>
    <dbReference type="FunCoup" id="Q6FXR9">
        <property type="interactions" value="408"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXR9"/>
    <dbReference type="EnsemblFungi" id="CAGL0A04653g-T">
        <property type="protein sequence ID" value="CAGL0A04653g-T-p1"/>
        <property type="gene ID" value="CAGL0A04653g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886409"/>
    <dbReference type="KEGG" id="cgr:2886409"/>
    <dbReference type="CGD" id="CAL0126535">
        <property type="gene designation" value="CAGL0A04653g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04653g"/>
    <dbReference type="eggNOG" id="KOG2438">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FXR9"/>
    <dbReference type="OMA" id="FELMFKE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="GatB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004012">
        <property type="entry name" value="PRK05477.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF0">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000413252" description="Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03147"/>
        </source>
    </evidence>
    <sequence length="542" mass="62767" checksum="4479BA070AE9EDFE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXT2</accession>
    <name>Q6FXT2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="5 6" type="ordered locus">CAGL0A04367g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXT2"/>
    <dbReference type="FunCoup" id="Q6FXT2">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886447"/>
    <dbReference type="CGD" id="CAL0126813">
        <property type="gene designation" value="CAGL0A04367g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04367g"/>
    <dbReference type="eggNOG" id="ENOG502SD3V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2292396_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXT2"/>
    <dbReference type="OMA" id="CWNNDIT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0126813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG57850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="120" mass="13769" checksum="0B747AFA4D12645C" modified="2004-07-19" version="1">MVEQQVPLRYQDRRKTEMLRFFGATMVTLVSCRLLMGKVAPKKVDSSLLRRTNFMSNHKPFTGTTSEKTGKDISMGLLYTTGMITGLISMGITGSCWNNDITTVDEFRERFRLDKEYLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY41</accession>
    <name>Q6FY41_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HXT4/6/7</name>
        <name evidence="12 13" type="ordered locus">CAGL0A02233g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
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        <property type="protein sequence ID" value="CAG57754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="cgr:2886373"/>
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    </dbReference>
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    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
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    <dbReference type="GO" id="GO:0005886">
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        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hexose transporter Hxt3p"/>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
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    </dbReference>
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        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
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        <property type="entry name" value="SP"/>
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    </dbReference>
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        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter"/>
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    </dbReference>
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        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
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            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="97"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="152"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="186"/>
            <end position="207"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="219"/>
            <end position="238"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="346"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="371"/>
            <end position="391"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="434"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="446"/>
            <end position="468"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="495"/>
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    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="50"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0126661"/>
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    </evidence>
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            <dbReference type="EMBL" id="CAG57754.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="549" mass="61215" checksum="E3F9325917650223" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY83</accession>
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            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4 5" type="ordered locus">CAGL0A04257g</name>
    </gene>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
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                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
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        <property type="entry name" value="HTH_MYB"/>
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    </dbReference>
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        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
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            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="112"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="115"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="229"/>
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        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="449"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="538"/>
        </location>
    </feature>
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        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0126879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG57845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="644" mass="69165" checksum="A0622D3ACA91639A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2025-06-18" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q708A7</accession>
    <accession>Q6FVP2</accession>
    <name>MATA1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mating-type-like protein A1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>MTL1a1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MTL1A1</name>
    </gene>
    <gene>
        <name type="primary">MTL2A1</name>
        <name type="ordered locus">CAGL0E00341g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Eukaryot. Cell" volume="2" first="328" last="340">
            <title>Three mating type-like loci in Candida glabrata.</title>
            <authorList>
                <person name="Srikantha T."/>
                <person name="Lachke S.A."/>
                <person name="Soll D.R."/>
            </authorList>
            <dbReference type="PubMed" id="12684382"/>
            <dbReference type="DOI" id="10.1128/EC.2.2.328-340.2003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>7549</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="1632" last="1637">
            <title>Evolution of the MAT locus and its Ho endonuclease in yeast species.</title>
            <authorList>
                <person name="Butler G."/>
                <person name="Kenny C."/>
                <person name="Fagan A."/>
                <person name="Kurischko C."/>
                <person name="Gaillardin C."/>
                <person name="Wolfe K.H."/>
            </authorList>
            <dbReference type="PubMed" id="14745027"/>
            <dbReference type="DOI" id="10.1073/pnas.0304170101"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Infect. Immun." volume="71" first="7109" last="7118">
            <title>Phenotypic switching and mating type switching of Candida glabrata at sites of colonization.</title>
            <authorList>
                <person name="Brockert P.J."/>
                <person name="Lachke S.A."/>
                <person name="Srikantha T."/>
                <person name="Pujol C."/>
                <person name="Galask R."/>
                <person name="Soll D.R."/>
            </authorList>
            <dbReference type="PubMed" id="14638801"/>
            <dbReference type="DOI" id="10.1128/IAI.71.12.7109-7118.2003"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text>Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="2">Only present in a-cells (classes I and IV).</text>
    </comment>
    <comment type="miscellaneous">
        <text>There are three genetic loci for mating type genes in C.glabrata. MTL1 seems to be the expression locus that determines the mating type of the cell, whereas MTL2 (containing MTL2A1) and MTL3 (containing MTL3ALPHA1 and MTL3ALPHA2) appear to represent silenced repositories of mating type information.</text>
    </comment>
    <comment type="miscellaneous">
        <text>Haploid C.glabrata strains can switch mating type, however, neither mating nor diploid forms of C.glabrata have been observed so far.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MATA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">It is uncertain whether Met-1 or Met-2 is the initiator.</text>
    </comment>
    <comment type="sequence caution" evidence="3">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAE84398" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AY191461">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY191462">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AJ617301">
        <property type="protein sequence ID" value="CAE84398.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q708A7"/>
    <dbReference type="SMR" id="Q708A7"/>
    <dbReference type="FunCoup" id="Q708A7">
        <property type="interactions" value="220"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0E00341g-T">
        <property type="protein sequence ID" value="CAGL0E00341g-T-p1"/>
        <property type="gene ID" value="CAGL0E00341g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887541"/>
    <dbReference type="CGD" id="CAL0128822">
        <property type="gene designation" value="MTL1a"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00341g"/>
    <dbReference type="HOGENOM" id="CLU_1937881_0_0_1"/>
    <dbReference type="InParanoid" id="Q708A7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0371">Homeobox</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000049174" description="Mating-type-like protein A1">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="14638801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="130" mass="15433" checksum="B0DA6DC6A3CD9A22" modified="2005-03-01" version="2">MMTVDPIQDLRNICLQILQSVNSNTLLEEETWDYNTLINNIDLPKQTREALRRSASQYLLYCQRKNKTYTTRKPLPAKAKLQLVETFSKKRYLTRCEKHQLAVQCGITTNQVQIWFANRRKRSKDLNNRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q874M2</accession>
    <accession>Q6FS67</accession>
    <name>NBP35_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytosolic Fe-S cluster assembly factor NBP35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleotide-binding protein 35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NBP35</name>
        <name type="ordered locus">CAGL0H03091g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Genome Biol." volume="4" first="R10.1" last="R10.9">
            <title>Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata.</title>
            <authorList>
                <person name="Wong S."/>
                <person name="Fares M.A."/>
                <person name="Zimmermann W."/>
                <person name="Butler G."/>
                <person name="Wolfe K.H."/>
            </authorList>
            <dbReference type="PubMed" id="12620120"/>
            <dbReference type="DOI" id="10.1186/gb-2003-4-2-r10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of 2 NBP35 and 2 CFD1 chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AY181249">
        <property type="protein sequence ID" value="AAO25609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446927.1">
        <property type="nucleotide sequence ID" value="XM_446927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q874M2"/>
    <dbReference type="SMR" id="Q874M2"/>
    <dbReference type="FunCoup" id="Q874M2">
        <property type="interactions" value="621"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q874M2"/>
    <dbReference type="EnsemblFungi" id="CAGL0H03091g-T">
        <property type="protein sequence ID" value="CAGL0H03091g-T-p1"/>
        <property type="gene ID" value="CAGL0H03091g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888580"/>
    <dbReference type="KEGG" id="cgr:2888580"/>
    <dbReference type="CGD" id="CAL0129625">
        <property type="gene designation" value="CAGL0H03091g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03091g"/>
    <dbReference type="eggNOG" id="KOG3022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_1"/>
    <dbReference type="InParanoid" id="Q874M2"/>
    <dbReference type="OMA" id="VSGCPMR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904564">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly scaffold complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000427">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF35">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000278892" description="Cytosolic Fe-S cluster assembly factor NBP35">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>ligand shared with heterodimeric partner</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <sequence length="334" mass="35955" checksum="63DF7F752327EE61" modified="2003-06-01" version="1">MSTEVISTSVVSEPTQEILPAEYSLDAPEPEHCPGPESEMAGKADACQTCENKDICESLPKGPDPDIPLITENLSGIKHKILVLSGKGGVGKSTFTTMLSWALSADDNLQVGAMDLDICGPSLPHMLGCTDEVVHESNTGWTPVYVAENLAAMSIQFMLPEDDSAVIWRGNKKNLLIKKFLKDVVWDDLDYLVVDTPPGTSDEHISINKYMKESGIDGALVVTTPQEVALLDVRKEIDFCRKAGINILGLVENMSGFVCPNCKGESQIFKPTTGGGEALCKELGIKFLGSVPLDPRIGRCSDEGESFLDEFPDSPATLAVLNVVEELRDAVGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN19</accession>
    <name>B4UN19_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase subunit K, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0I07969g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAR58035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN19"/>
    <dbReference type="FunCoup" id="B4UN19">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UN19"/>
    <dbReference type="KEGG" id="cgr:9488013"/>
    <dbReference type="CGD" id="CAL0132466">
        <property type="gene designation" value="CAGL0I07969g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07969g"/>
    <dbReference type="eggNOG" id="ENOG502S99W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172736_1_2_1"/>
    <dbReference type="InParanoid" id="B4UN19"/>
    <dbReference type="OMA" id="FQPHQLA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0132466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAR58035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7031" checksum="A3E69F88236CC4C7" modified="2008-09-23" version="1">MGSAYQILGRSFQPHQLAIGTLSLVALVAMPNPFAAKKAKEVEIQASSKEEEKFIKEYLEKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-31" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>F2Z631</accession>
    <name>F2Z631_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E3 ubiquitin ligase complex SCF subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CBF3D</name>
        <name evidence="7 8" type="ordered locus">CAGL0M01364g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F2Z631"/>
    <dbReference type="FunCoup" id="F2Z631">
        <property type="interactions" value="945"/>
    </dbReference>
    <dbReference type="STRING" id="284593.F2Z631"/>
    <dbReference type="KEGG" id="cgr:2891173"/>
    <dbReference type="CGD" id="CAL0137041">
        <property type="gene designation" value="CBF3D"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01364g"/>
    <dbReference type="eggNOG" id="KOG1724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059252_6_1_1"/>
    <dbReference type="InParanoid" id="F2Z631"/>
    <dbReference type="OMA" id="DKYTASM"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031518">
        <property type="term" value="C:CBF3 complex"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043254">
        <property type="term" value="P:regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000133">
        <property type="entry name" value="Suppressor of kinetochore protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="7"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="129"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0137041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="179" mass="20888" checksum="C51C660A4DA4071A" modified="2011-05-31" version="1">MDKKGKYVVLVSGEGEKFTVEKKIAQRSLLLKNYLNDMHESSLDDEDEEQDEDEDEDDEIVMPVPNVRSSVLQKVIEWAEHHRDSNFPDEDDDDSRKSAPVDAWDREFLKVDQEMLYEIILAANYLNIKPLLDAGCKVVAEMIRGRSPEEIRRTFNIVNDFTPEEEAAIRRENEWAEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIU6</accession>
    <name>Q6FIU6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">glycerol-1-phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0M11660g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>sn-glycerol 1-phosphate + H2O = glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:46084"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="EC" id="3.1.3.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>sn-glycerol 3-phosphate + H2O = glycerol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:66372"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="EC" id="3.1.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the HAD-like hydrolase superfamily. DOG/GPP family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.21" evidence="13"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449848.1">
        <property type="nucleotide sequence ID" value="XM_449848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIU6"/>
    <dbReference type="FunCoup" id="Q6FIU6">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIU6"/>
    <dbReference type="KEGG" id="cgr:2891243"/>
    <dbReference type="CGD" id="CAL0136557">
        <property type="gene designation" value="CAGL0M11660g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11660g"/>
    <dbReference type="eggNOG" id="KOG2914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_4_1"/>
    <dbReference type="InParanoid" id="Q6FIU6"/>
    <dbReference type="OMA" id="QVHTFDG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000121">
        <property type="term" value="F:sn-glycerol 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006114">
        <property type="term" value="P:glycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07527">
        <property type="entry name" value="HAD_ScGPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000012">
        <property type="entry name" value="Glycerol-1-phosphate phosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000033">
        <property type="entry name" value="Sugar phosphatase YfbT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00037">
        <property type="entry name" value="glycerol-3-phosphate_phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0136557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG62828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="248" mass="27772" checksum="FA3555FF9CF9869A" modified="2004-07-19" version="1">MSTSPVSLKVNAALFDVDGTIIISQPAIAAFWRDFGKDKPYFDAEHVIHISHGWRTYDAIAKFAPDYADEEYVNKLEGEIPEKYGEHSIEVPGAVKLCTDLNKLPKEKWAVATSGTRDMAQKWFKILNIERPEYFITANDVKQGKPFPEPYLKGREGLGFPINKEDPSKSKVVVFEDAPAGIAAGKAAGCKIIGIATTFDVDFLKEKGCDIIVKNHESIRVGGYNPETDEVEFIFDDYLYAKDDLLEW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIY7</accession>
    <name>ATP23_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber>3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATP23</name>
        <name type="ordered locus">CAGL0M10593g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Mitochondrion inner membrane</location>
            <topology>Peripheral membrane protein</topology>
            <orientation>Intermembrane side</orientation>
        </subcellularLocation>
        <text evidence="1">Associates loosely with the inner membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M76 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449807.1">
        <property type="nucleotide sequence ID" value="XM_449807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIY7"/>
    <dbReference type="FunCoup" id="Q6FIY7">
        <property type="interactions" value="513"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIY7"/>
    <dbReference type="MEROPS" id="M76.002"/>
    <dbReference type="EnsemblFungi" id="CAGL0M10593g-T">
        <property type="protein sequence ID" value="CAGL0M10593g-T-p1"/>
        <property type="gene ID" value="CAGL0M10593g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891372"/>
    <dbReference type="KEGG" id="cgr:2891372"/>
    <dbReference type="CGD" id="CAL0136521">
        <property type="gene designation" value="CAGL0M10593g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M10593g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M10593g"/>
    <dbReference type="eggNOG" id="KOG3314">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079125_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIY7"/>
    <dbReference type="OMA" id="EAHQNCV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000330058" description="Mitochondrial inner membrane protease ATP23">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="225" mass="26631" checksum="3D42DF3979308F69" modified="2004-07-19" version="1">MAGESFEWWRRTMQYQTGLGLTADEKARYEKDYAVYNREKQCKSCYEYRDWMLKYSPTVRFMIQQISKLNGNASDGKVLNFDESKIICDECPDWKSGGFHPEIGILLCQNRLKDKWHLEDTLSHELVHYFDNLKWQIDWLNLKQHACSEIRASALSGECRFSREFARLGFSMNFGRGHQDCAKRRAIISVMGNPNCKDKEHATKVVEEVWDSCFYDTRPFEEIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ20</accession>
    <name>Q6FJ20_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">CAGL0M09845g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ20"/>
    <dbReference type="FunCoup" id="Q6FJ20">
        <property type="interactions" value="1232"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ20"/>
    <dbReference type="KEGG" id="cgr:2891338"/>
    <dbReference type="eggNOG" id="KOG1539">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002774_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ20"/>
    <dbReference type="OMA" id="CIYAWRA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000410">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000710">
        <property type="entry name" value="U3 snoRNP protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="47"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="579"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="711"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="785"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="936" mass="104205" checksum="92A8538EE15EF692" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ95</accession>
    <name>Q6FJ95_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YL17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M08118g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL22 is associated with the polypeptide exit tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ95"/>
    <dbReference type="FunCoup" id="Q6FJ95">
        <property type="interactions" value="1145"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ95"/>
    <dbReference type="KEGG" id="cgr:2891258"/>
    <dbReference type="CGD" id="CAL0137093">
        <property type="gene designation" value="CAGL0M08118g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08118g"/>
    <dbReference type="eggNOG" id="KOG3353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ95"/>
    <dbReference type="OMA" id="NTYETAR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00082773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0137093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="184" mass="20635" checksum="09AA595A886A6563" modified="2004-07-19" version="1">MARYGATSTNPAKSASARGSYLRVSFKNTRETAQAINGWELTKAQKYLDQVLEHQRAIPFRRYNSSIGRTAQGKEFGVTKARWPAKSVKFIQGLLQNAAANAEAKGLDATKLYVSHIQVNHAPKQRRRTYRAHGRINKYESSPSHIELVVTEKEEAVAKAAEKKLVRLSSRQRGRIASQKRITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ99</accession>
    <name>Q6FJ99_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M08030g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ99"/>
    <dbReference type="FunCoup" id="Q6FJ99">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ99"/>
    <dbReference type="KEGG" id="cgr:2891747"/>
    <dbReference type="CGD" id="CAL0137319">
        <property type="gene designation" value="CAGL0M08030g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08030g"/>
    <dbReference type="eggNOG" id="KOG0546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_37_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ99"/>
    <dbReference type="OMA" id="QFFITTY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0137319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="387" mass="44246" checksum="B08DAE7CC2352165" modified="2004-07-19" version="1">MKVYLDIAIAGEQIGRIVCELYNDKAPKAVENFHRLCVGSGSVGGIHLTYKRSCFHRVIRNFMIQGGDLVFGKEDNLDSDKVGLGGCSIYATEEEIKDDTKELQCHGLFEDENVGEFDEPFLLAMANTGSPNTNSSQFFITTYPSPHLTGKHSIFGRVIHGKSVVRTIEYGKVDKEGTPENLVVIEDCGDWDETMSIPLYNASNSTIGGDIYEEYPDDDTHFDSEDFAAAYNASNIIKDSGSALFKIKDYQNSYYKYMKALKYVNTYIPEQDVDEKHCLLFIELKKKLYLNICLALFNLKDYDESMKYGHYLLELDSVDDKDKAKAYYRIGNSLFAKKRYDEALKNYRLCRDHNPDDNVIGQKIEKTENILEKEKERTKKNISKFFR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJB0</accession>
    <name>CLU_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CLU1</name>
        <name evidence="1" type="synonym">TIF31</name>
        <name type="ordered locus">CAGL0M07722g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLU family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449684.1">
        <property type="nucleotide sequence ID" value="XM_449684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJB0"/>
    <dbReference type="SMR" id="Q6FJB0"/>
    <dbReference type="FunCoup" id="Q6FJB0">
        <property type="interactions" value="1119"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJB0"/>
    <dbReference type="EnsemblFungi" id="CAGL0M07722g-T">
        <property type="protein sequence ID" value="CAGL0M07722g-T-p1"/>
        <property type="gene ID" value="CAGL0M07722g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891734"/>
    <dbReference type="KEGG" id="cgr:2891734"/>
    <dbReference type="CGD" id="CAL0136551">
        <property type="gene designation" value="CAGL0M07722g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M07722g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07722g"/>
    <dbReference type="eggNOG" id="KOG1839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003256_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FJB0"/>
    <dbReference type="OMA" id="HPVWDKD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0802">TPR repeat</keyword>
    <feature type="chain" id="PRO_0000366401" description="Clustered mitochondria protein homolog">
        <location>
            <begin position="1"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 1">
        <location>
            <begin position="64"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Clu" evidence="2">
        <location>
            <begin position="329"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 2">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 3">
        <location>
            <begin position="716"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 4">
        <location>
            <begin position="795"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 5">
        <location>
            <begin position="904"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 6">
        <location>
            <begin position="1010"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR 7">
        <location>
            <begin position="1138"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1224"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1254"/>
            <end position="1267"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="1267" mass="143838" checksum="6FF5FAAB74C26B8C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJE7</accession>
    <name>Q6FJE7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">EFM6</name>
        <name evidence="3 4" type="ordered locus">CAGL0M06897g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449647.1">
        <property type="nucleotide sequence ID" value="XM_449647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJE7"/>
    <dbReference type="FunCoup" id="Q6FJE7">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJE7"/>
    <dbReference type="GeneID" id="2891696"/>
    <dbReference type="KEGG" id="cgr:2891696"/>
    <dbReference type="CGD" id="CAL0137099">
        <property type="gene designation" value="CAGL0M06897g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06897g"/>
    <dbReference type="eggNOG" id="KOG2793">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055721_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FJE7"/>
    <dbReference type="OMA" id="RRADMRF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0137099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="248" mass="28000" checksum="FF198D3BFD72B023" modified="2004-07-19" version="1">MEDILGFGDLIESRPVEHMGQSDLTFNGMLVPGLKIYEDGGESGCGGKVWIAGELLCEFILEKSRDGELLKDWINDDSVSFGNVLELGSGTGLVGLCVGLVTKKQSQRMVKTYITDIDQLVPLMEKNVELNLIDQQVFAKELLWGEALPIEFAPVKTGHATTSSLDLVLAADCVYLEKAFPLLEKTLLDLTECDNPPVILMAYRKRRKADKHFFQKIRKNFNVIVINDFKNYDQYLKQRTHLFQLVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="156" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJT6</accession>
    <name>Q6FJT6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0M03729g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJT6"/>
    <dbReference type="FunCoup" id="Q6FJT6">
        <property type="interactions" value="363"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJT6"/>
    <dbReference type="KEGG" id="cgr:2891518"/>
    <dbReference type="CGD" id="CAL0136745">
        <property type="gene designation" value="CAGL0M03729g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03729g"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_26_2_1"/>
    <dbReference type="InParanoid" id="Q6FJT6"/>
    <dbReference type="OMA" id="NFTHRVH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120157">
        <property type="term" value="C:PAR polarity complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000910">
        <property type="term" value="P:negative regulation of sterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042307">
        <property type="term" value="P:positive regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035376">
        <property type="term" value="P:sterol import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000356">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="11">
        <location>
            <begin position="60"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="13">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="564"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="247"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="383"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="492"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="247"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0136745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG62484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="861" mass="94832" checksum="EF08E46E683EF20D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJZ3</accession>
    <name>Q6FJZ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M02409g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJZ3"/>
    <dbReference type="FunCoup" id="Q6FJZ3">
        <property type="interactions" value="727"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJZ3"/>
    <dbReference type="KEGG" id="cgr:2891459"/>
    <dbReference type="CGD" id="CAL0136237">
        <property type="gene designation" value="CAGL0M02409g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02409g"/>
    <dbReference type="eggNOG" id="KOG2823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035888_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FJZ3"/>
    <dbReference type="OMA" id="TEKWTHK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="447" mass="52007" checksum="B8A06F8F381CFC22" modified="2004-07-19" version="1">MAPLKVNERPAQYKQSSRKGKKAWRKNIDLTDIEKSIETQKDLEITHGTSDLASLQDTALFQVDEEGDIDLKKALIKRKQIKKNLKSKEILDSIKTASKIKSVIHPRHQEHQTKEGGKVQGVSKKELKKLLSLAGKIQGESKLKNRSDKDGLVKSAAADLWNEEESNKVKLPSGIEFKKKRDEIPEELIKYSTTSWSIAEVKPKTLEHKPVKVAEYEDLPHAGKSYNPDSKHWNSLISKEYESEKKREDARNKIQEYQAKIQRLMEVLDDKEEESSSEEDEEDEEDETEETTESTDVTLGLSINPVVKNKKKTKYQKNKAKRHEEKVKMHKEIKELKQQIKELEKIEEIEQEVEKRHEEKDKKVKKEKKNKKGKLGTKYHILNEGLEVKFKDELSDSLRKVRPEGSLLYDTVRKLQSSGKVEARIPRTKGRRYKQKITEKWTYKDFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKC0</accession>
    <name>Q6FKC0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">DIG1</name>
        <name evidence="2 3" type="ordered locus">CAGL0L12782g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449324.1">
        <property type="nucleotide sequence ID" value="XM_449324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKC0"/>
    <dbReference type="STRING" id="284593.Q6FKC0"/>
    <dbReference type="GeneID" id="2890610"/>
    <dbReference type="KEGG" id="cgr:2890610"/>
    <dbReference type="CGD" id="CAL0135274">
        <property type="gene designation" value="DIG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12782g"/>
    <dbReference type="HOGENOM" id="CLU_1049717_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKC0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="265" mass="29648" checksum="4615D973DD79BCCD" modified="2004-07-19" version="1">MPVKVKVKRERVDESLKRKRPPPLEFKRKRNVVVRYVGPTVRRIPLFVPQYVPTPMYFLPQPYQVEHRGKNKIVDIMSPITHGVAEGVTVAEEDSQDDCEDDHSIEERDEDKVDGEAEAEAVAVSEAEGEAEAGPEIPSGAGDDTCTGGQGTLENHHITSQETNQDIEYKADQEEGEKTCVEANCDGDKKCEEDDDHSHLAIEDGAIPTPNITRDVQGAFTKDVQGAITINNHSYEFQFPSRTADTDRKLFLSICNKIWSERPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKC5</accession>
    <name>Q6FKC5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0L12672g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="CAG62293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKC5"/>
    <dbReference type="KEGG" id="cgr:2890605"/>
    <dbReference type="CGD" id="CAL0135902">
        <property type="gene designation" value="CAGL0L12672g"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG0127">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011608_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FKC5"/>
    <dbReference type="OMA" id="FTHRHAL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12677">
        <property type="entry name" value="RRM4_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NOP4p Nucleolar protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000937">
        <property type="entry name" value="NOP4p Nucleolar protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034809">
        <property type="entry name" value="Nop4_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="4"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="144"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="462"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
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        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
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            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
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            <begin position="260"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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            <end position="658"/>
        </location>
    </feature>
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        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0135902"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CAG62293.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="682" mass="77591" checksum="DE9E5D0E89038A1B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKE9</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1 2" type="ordered locus">CAGL0L12122g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
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                <person name="Thierry A."/>
                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="CGD" id="CAL0135810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="263" mass="31317" checksum="96ABD03DD1AA2DE6" modified="2004-07-19" version="1">MMAIVDENYKNNRQEEALQFIGYISFDKINQMNNRMLKNIDQNINTSIELVENVKDRFSKDDPSVNYKRGEITSNYDSQKYNAQSPSISKTLNYFQSHEKNVIMVDDQPLILTNTNHFSPDYPPFYRTYKYDHRLNELGANDVVSAMVQNEINDNNDYFNCELEYVEKKTKFLHWYDYVLYHLFSIDRLGYFKLEIWRQKYQHSPWKSQINDRLFNADTNSINESMGDEDYDPESLINTRSTNKWSNSKRSGFTSLRSFFGMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKQ5</accession>
    <name>Q6FKQ5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinetochore protein mis13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAGL0L09603g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2019" name="Chromosoma" volume="128" first="331" last="354">
            <title>The molecular basis of monopolin recruitment to the kinetochore.</title>
            <authorList>
                <person name="Plowman R."/>
                <person name="Singh N."/>
                <person name="Tromer E.C."/>
                <person name="Payan A."/>
                <person name="Duro E."/>
                <person name="Spanos C."/>
                <person name="Rappsilber J."/>
                <person name="Snel B."/>
                <person name="Kops G.J.P.L."/>
                <person name="Corbett K.D."/>
                <person name="Marston A.L."/>
            </authorList>
            <dbReference type="PubMed" id="31037469"/>
            <dbReference type="DOI" id="10.1007/s00412-019-00700-0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.79 ANGSTROMS) OF 31-55</scope>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="6MJB">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.27 A"/>
        <property type="chains" value="C=2-60"/>
    </dbReference>
    <dbReference type="PDB" id="6MJC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.79 A"/>
        <property type="chains" value="B=31-55"/>
    </dbReference>
    <dbReference type="PDBsum" id="6MJB"/>
    <dbReference type="PDBsum" id="6MJC"/>
    <dbReference type="AlphaFoldDB" id="Q6FKQ5"/>
    <dbReference type="SMR" id="Q6FKQ5"/>
    <dbReference type="FunCoup" id="Q6FKQ5">
        <property type="interactions" value="527"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKQ5"/>
    <dbReference type="KEGG" id="cgr:2891139"/>
    <dbReference type="eggNOG" id="ENOG502QQ6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022497_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKQ5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="6MJB"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="6MJC"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52805" checksum="C7540DBB143500A1" modified="2004-07-19" version="1">MGDKDNGLHAGETDGDDEGFEFRRHSNLGVPTLGERLDSLHEIKSARRMDHFNSSRNSLRGGTASSSQQVPEVDNRAHINGINTSLQVEGNSSVKYLVPLEYVTDSGSIPRDKLIKVIDNEAALKSSLNERARNKRLSLSQRGRRLSMLSTGVDRHVIVSPHKEVPEQEFYKHVGDLSFGKSLQLRQLFNWCCDRTYTRIQEADRKKTQSQTLEENGSYGDPKKITMNIIKSFVHDLKKGTLDIDWEAEEEEEEDDYSGNGNDTELNALFDDHNDGNTRHTSARQNLTLYDDEFDITLGIQPTRPELEYRNNKKNNRQSTRKRKIQTPHKKLPNTKNVENEKNLIMLKQKIDILENDINEWANTLDSHDPQKEWQLIKDVKPDNTTPEQTITNANPVKELEDRLKAMSMNAHLLDSTSKTLLELSRIKLDKLRRAYYDTAKNEKKQIESTRLLRGLASSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKT7</accession>
    <name>Q6FKT7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor TFIID subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L08778g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FKT7">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKT7"/>
    <dbReference type="KEGG" id="cgr:2890634"/>
    <dbReference type="CGD" id="CAL0135188">
        <property type="gene designation" value="CAGL0L08778g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08778g"/>
    <dbReference type="eggNOG" id="ENOG502S96D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_704112_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKT7"/>
    <dbReference type="OMA" id="MDNTFQR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44874" checksum="11D5E131B2F1596F" modified="2004-07-19" version="1">MTNNEAFFFGLLRVSMLQLLKSHGFDKALPSTVDAFTDLYVKFLDLLVSEVQGAMQLRGDKYMETVAIQDITAGMEAVGLLKPMKLLDVYGERVPDDSNTGAEAFKKWCTDVQVRNSRQVALPSVDLLTAEANGSKSTKPLNALPDYINQLQQKKEPSRSNSITKQPMLPDMAPQLPFHSQDEHVHELIEELINNGETDDWIRMVLARQRIELGKKHSRKPGTLENLPNIPSMKFSALSSLLPSEEDAKNEFLPSNGEVDETNSGKDLETTASEVTASDKTKDKLSQLTQYLPISKPENRLQNIALSYENEQDDADEINDGIDDYHSESASPATLTDEKLIDDIQSMGPMHLQNDIAVEDDDMMPMDYQFDDPDAMFDEQEDMDNTFQRRASLDFGSHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKV8</accession>
    <name>Q6FKV8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0L08272g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKV8"/>
    <dbReference type="FunCoup" id="Q6FKV8">
        <property type="interactions" value="1566"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKV8"/>
    <dbReference type="KEGG" id="cgr:2890563"/>
    <dbReference type="CGD" id="CAL0135356">
        <property type="gene designation" value="CAGL0L08272g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08272g"/>
    <dbReference type="eggNOG" id="KOG0363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008891_6_2_1"/>
    <dbReference type="InParanoid" id="Q6FKV8"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0135356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="526" mass="57012" checksum="3FE4E0E7568C5522" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL65</accession>
    <name>Q6FL65_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nucleoporin NUP49/NSP49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0L05852g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL65"/>
    <dbReference type="FunCoup" id="Q6FL65">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL65"/>
    <dbReference type="KEGG" id="cgr:2890809"/>
    <dbReference type="CGD" id="CAL0135924">
        <property type="gene designation" value="CAGL0L05852g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05852g"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039862_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL65"/>
    <dbReference type="OMA" id="SHHLKAD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990000">
        <property type="term" value="P:amyloid fibril formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0135924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="51174" checksum="6D78DFE138E61014" modified="2004-07-19" version="1">MFGLNKPSTGLFGNNNAGANTGSGFGSNAGQSSGGGLFGSTSNNNTGLFGGANSNNMAGQNNTTTGGGLFGNSNATGAGGGLFGNSNSNTTGNAASSGGLFGNNNTNTATGTTTGGGLFGNNTSTGGLFGTNNNAGSTSTGGGLFGTNNNTGNTSTGGGLFGASKPATGGLFGNNSNNTATTNSASTGGGLFGNSSNTMNATGGMGGLFGNKPAQGIGSTGTSLFGNNQNSAGTTSGLGGGGLFGSKPTTGSSLFGGNSSNTGFGSNTNGGLFGAVQQQQQPQSALESINQLAITPLTRISDLPPQIRAEVEQLDQYIQKQVQISEHLKADDKDHDELVSSIPRDIAYLTKVQSMTMQSLQMDLKRISKSKELTDNNLSDTQMFAIILQQILTPGSKISSLELEKFFQAKIAMYQSKLDDYFRVLSDIESAVNGIHCDIFGGSHEISGSDGLSNNDNAQEDLYAMKTGLNAIISTVIEEFKLFMSTADQIASLHQKVKLLTSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLK6</accession>
    <name>Q6FLK6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0L02695g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLK6"/>
    <dbReference type="STRING" id="284593.Q6FLK6"/>
    <dbReference type="KEGG" id="cgr:2890861"/>
    <dbReference type="CGD" id="CAL0136090">
        <property type="gene designation" value="CAGL0L02695g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02695g"/>
    <dbReference type="eggNOG" id="ENOG502RYXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020680_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FLK6"/>
    <dbReference type="OMA" id="QAMHNWE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="5">
        <location>
            <begin position="373"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0136090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="459" mass="52527" checksum="76E0DE36207B6DA8" modified="2004-07-19" version="1">MAKKKNNKKKAAPAAAPVAEQPAEVSEKEVEVEVPLERLDGAQDSEDDSRLEADKHEQNSEEVGSDKVDNEVEETRNDGAENSNTGNTDENIREELERVKTERDQVESQYQTLLSRLSSMKTIFSKMKESEAELEVVKEQLQEYENQNLNLKNKVSLLTKEKKELEETATTLNKELESLESEQESNDDKLKESQTRIKELEHQLEAKSEISKSESGRLKKENEQLNSQVQELLVVIDNNKQDLSASKEEIEDLKQNVENLENEKVKLQNAFNDMELQLDAVEKANKEQLDEKNLEINALRTQLDQAIEAKNAEISKMEELEKKLAAMKQDVTLKEKFEKESKEHASQIAKLRHETIVLNEHLTKALAMLKQSSDSESVDKELISNLLISFVSIPRADPRKFEVLELLSNFLNWDDDQKRQAGLIFTPGQDNNNGSKIPSRTESFVAMWTDFLERESEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLK9</accession>
    <name>Q6FLK9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0L02629g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLK9"/>
    <dbReference type="FunCoup" id="Q6FLK9">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLK9"/>
    <dbReference type="KEGG" id="cgr:2890860"/>
    <dbReference type="CGD" id="CAL0135200">
        <property type="gene designation" value="CAGL0L02629g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02629g"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_103_3_1"/>
    <dbReference type="InParanoid" id="Q6FLK9"/>
    <dbReference type="OMA" id="WDIAKMK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043224">
        <property type="term" value="C:nuclear SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050815">
        <property type="term" value="F:phosphoserine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031740">
        <property type="entry name" value="Cdc4_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16856">
        <property type="entry name" value="CDC4_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="258"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="405"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="446"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="518"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="558"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="620"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="756"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0135200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="795" mass="87566" checksum="4AB4E82670037BCC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLM5</accession>
    <name>Q6FLM5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Poly(A) polymerase</fullName>
            <ecNumber evidence="13">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22" type="ordered locus">CAGL0L02277g</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="13"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLM5"/>
    <dbReference type="FunCoup" id="Q6FLM5">
        <property type="interactions" value="1090"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLM5"/>
    <dbReference type="KEGG" id="cgr:2890899"/>
    <dbReference type="CGD" id="CAL0135270">
        <property type="gene designation" value="CAGL0L02277g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02277g"/>
    <dbReference type="eggNOG" id="KOG2245">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011511_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FLM5"/>
    <dbReference type="OMA" id="EWKWPQP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071920">
        <property type="term" value="C:cleavage body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033620">
        <property type="term" value="C:Mei2 nuclear dot complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990251">
        <property type="term" value="C:nuclear exosome focus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033621">
        <property type="term" value="P:nuclear mRNA surveillance of meiosis-specific transcripts"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000003">
        <property type="entry name" value="Poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="20">
        <location>
            <begin position="8"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="19">
        <location>
            <begin position="206"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="18">
        <location>
            <begin position="353"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="523"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0135270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG61839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="569" mass="64766" checksum="7749892D09BBEBA7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLN1</accession>
    <name>Q6FLN1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L02145g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLN1"/>
    <dbReference type="FunCoup" id="Q6FLN1">
        <property type="interactions" value="160"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLN1"/>
    <dbReference type="KEGG" id="cgr:2890893"/>
    <dbReference type="CGD" id="CAL0135964">
        <property type="gene designation" value="CAGL0L02145g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02145g"/>
    <dbReference type="eggNOG" id="KOG2740">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026449_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLN1"/>
    <dbReference type="OMA" id="LNEMCDG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="237"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="543" mass="61210" checksum="A0A4D9B0986F1F38" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-06-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLQ1</accession>
    <name>BLI1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Biogenesis of lysosome-related organelles complex 1 subunit BLI1</fullName>
            <shortName>BLOC-1 subunit BLI1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName>BLOC-1 interactor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">BLI1</name>
        <name type="ordered locus">CAGL0L01683g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448843.1">
        <property type="nucleotide sequence ID" value="XM_448843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLQ1"/>
    <dbReference type="FunCoup" id="Q6FLQ1">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLQ1"/>
    <dbReference type="EnsemblFungi" id="CAGL0L01683g-T">
        <property type="protein sequence ID" value="CAGL0L01683g-T-p1"/>
        <property type="gene ID" value="CAGL0L01683g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890887"/>
    <dbReference type="KEGG" id="cgr:2890887"/>
    <dbReference type="CGD" id="CAL0135632">
        <property type="gene designation" value="CAGL0L01683g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L01683g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01683g"/>
    <dbReference type="HOGENOM" id="CLU_168467_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLQ1"/>
    <dbReference type="OMA" id="AVANHEW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020491">
        <property type="entry name" value="BLI1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17324">
        <property type="entry name" value="BLI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000410613" description="Biogenesis of lysosome-related organelles complex 1 subunit BLI1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="103" mass="12217" checksum="6E12D5D24953F9D0" modified="2004-07-19" version="1">MIKQDVQKCVDALQDFVDKEIGESVNLFSCKSRANNELLLNIDEKFQLKDKDELHQLGEQKIENQNKLQEIRNKVEYYEKLLTELEEAQKELEVRYKLVSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM18</accession>
    <name>Q6FM18_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RP41</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S18</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">YS12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RPS11B</name>
        <name evidence="10 11" type="ordered locus">CAGL0K11748g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM18"/>
    <dbReference type="FunCoup" id="Q6FM18">
        <property type="interactions" value="1284"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM18"/>
    <dbReference type="KEGG" id="cgr:2890530"/>
    <dbReference type="CGD" id="CAL0134785">
        <property type="gene designation" value="RPS11B"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11748g"/>
    <dbReference type="eggNOG" id="KOG1728">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FM18"/>
    <dbReference type="OMA" id="DYEKCPF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00077551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0134785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="156" mass="17894" checksum="412ACDE8601C0BA0" modified="2004-07-19" version="1">MSTELTVQSERAFQKQPHIFSNPKFKTSKRTKRWYKNAGLGFKTPKTAIEGSYIDKKCPFTGLVSIRGKILSGTVVSTKMHRTIIIRRDYLHYVPKYNRYEKRHKNVPVHVSPAFRVQVGDIVTVGQCRPISKTVRFNVLKVAAATGKANKQFHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM48</accession>
    <name>Q6FM48_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0K11044g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM48"/>
    <dbReference type="FunCoup" id="Q6FM48">
        <property type="interactions" value="676"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM48"/>
    <dbReference type="KEGG" id="cgr:2890084"/>
    <dbReference type="CGD" id="CAL0134433">
        <property type="gene designation" value="CAGL0K11044g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11044g"/>
    <dbReference type="eggNOG" id="KOG0398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FM48"/>
    <dbReference type="OMA" id="HITIHTT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="5">
        <location>
            <begin position="127"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="6">
        <location>
            <begin position="185"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="283" mass="32096" checksum="2B6FBBDDE2FD2DAB" modified="2004-07-19" version="1">MLGRRAFSSTSGAGKAACSLVKPVHHLVRIDKNKLSPRFPDLKYEKTDVRSPGYRPQEVCGDRVRDFYHSTLQQDMLLINYRHGQEVERGLKKREWDGSSPYHLNRPLKKPQGSMAQLPDIKPVKWHNVPWLENVTINCFVKEAKENELMAVSAALQLQQITGAKPKPIYSKTDVPTWKLRKGHQMGAKVVLTGYEMSQFLSTLTEIVLPRIREYKGVKPNGDRFGGISFGMTSSDVRFFPEIDANQDLWPKTFGMHVNINTTAQNTAQAVTLLSGLQFPFQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM51</accession>
    <name>LYS4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Homoaconitase, mitochondrial</fullName>
            <ecNumber>4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">LYS4</name>
        <name type="ordered locus">CAGL0K10978g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448693.1">
        <property type="nucleotide sequence ID" value="XM_448693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM51"/>
    <dbReference type="SMR" id="Q6FM51"/>
    <dbReference type="FunCoup" id="Q6FM51">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM51"/>
    <dbReference type="EnsemblFungi" id="CAGL0K10978g-T">
        <property type="protein sequence ID" value="CAGL0K10978g-T-p1"/>
        <property type="gene ID" value="CAGL0K10978g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890081"/>
    <dbReference type="KEGG" id="cgr:2890081"/>
    <dbReference type="CGD" id="CAL0134839">
        <property type="gene designation" value="CAGL0K10978g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10978g"/>
    <dbReference type="eggNOG" id="KOG0453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FM51"/>
    <dbReference type="OMA" id="LCDADNI"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000016">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000000549" description="Homoaconitase, mitochondrial">
        <location>
            <begin position="18"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="689" mass="74540" checksum="D69557A9FD81BF1D" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMA4</accession>
    <name>Q6FMA4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K09702g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448640.1">
        <property type="nucleotide sequence ID" value="XM_448640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMA4"/>
    <dbReference type="FunCoup" id="Q6FMA4">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMA4"/>
    <dbReference type="KEGG" id="cgr:2890243"/>
    <dbReference type="CGD" id="CAL0134271">
        <property type="gene designation" value="CAGL0K09702g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09702g"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_16_1_1"/>
    <dbReference type="InParanoid" id="Q6FMA4"/>
    <dbReference type="OMA" id="LTLMWAN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="14"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="373" mass="40849" checksum="AC69BC91C98A7503" modified="2004-07-19" version="1">MSIPATMKAAVIDGDHLTVKEVPVPEVRDGMVLIKTRAVAGNPTDWKHIVSKIGPQGSISGCDVSGEIVKIGANVDTSKYKIGQKAYGLTHGSSVKHPDNGAFAEYSLLDPKIAYFPNQDITMSGKDTIPEGTVKYFEDGASFPVSLTTAGAVLHSNLGLDLKWEPSEPQRDHPVLFWGGATGVGQLLIQVAKKIHGFTKIVTVASKKHEAQLKTYGADEVFDYHDADVIEQIKKKYPDLQIVVDCVSNENTIKQVYKCATESKSATIVQLTHLSIKDIPEEDRRDNKTIIGSMLYLATGEDVPFGPVHLPADPKFRKDVEEFVAFINPRINEGIIHHIPIKIYKNGLDDVQQILDDIKFGKNSGEKLVAILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMB9</accession>
    <name>Q6FMB9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">THR4</name>
        <name evidence="15 16" type="ordered locus">CAGL0K09328g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10841"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448625.1">
        <property type="nucleotide sequence ID" value="XM_448625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMB9"/>
    <dbReference type="FunCoup" id="Q6FMB9">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMB9"/>
    <dbReference type="GeneID" id="2890257"/>
    <dbReference type="KEGG" id="cgr:2890257"/>
    <dbReference type="CGD" id="CAL0134515">
        <property type="gene designation" value="THR4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09328g"/>
    <dbReference type="eggNOG" id="KOG2616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015170_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FMB9"/>
    <dbReference type="OMA" id="NFERYLY"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000046">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="14">
        <location>
            <begin position="7"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="109"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0134515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG61588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="512" mass="57485" checksum="17684ADA06AE29F3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FME8</accession>
    <name>Q6FME8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hap4 transcription factor heteromerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HAP4</name>
        <name evidence="4 5" type="ordered locus">CAGL0K08624g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448596.1">
        <property type="nucleotide sequence ID" value="XM_448596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FME8"/>
    <dbReference type="FunCoup" id="Q6FME8">
        <property type="interactions" value="835"/>
    </dbReference>
    <dbReference type="GeneID" id="2890323"/>
    <dbReference type="KEGG" id="cgr:2890323"/>
    <dbReference type="CGD" id="CAL0134441">
        <property type="gene designation" value="HAP4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08624g"/>
    <dbReference type="eggNOG" id="ENOG502SGDX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801667_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FME8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043457">
        <property type="term" value="P:regulation of cellular respiration"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hap4 transcription factor heteromerisation" evidence="3">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0134441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="346" mass="37631" checksum="6FC225C637BABEBE" modified="2004-07-19" version="1">MHPVPIAPNLHRPSTGSARLVVRTSKNWVLPPRPRPNRRNTIHSGANSSHTHTNNTHTNNAGNASSATTAVNSAATSAASTPAPPKRKRENSLPVNLKKVKKDYNRVENCLAFLKFDDEEDTTTTSTDIDDDLFSNTSPVSSTCTPLTSASLNLKSVPFNGASAVSGVGMLNLSAGKNGAQKKQQRAKSAQYSYKPSSKDDSKYGNESTLDGDLDLEMEMSMNLDDNINATSFTTATESKPEFFTINNITNATTSASPALNDPVTTDSSLSAKELEDFYNYIPPSLEELIDEQDAHSKNNNGLFRDSLMSKSYESMNLMMFNDPSNTARQQDDLIVDTDGDMFAFI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMP5</accession>
    <name>PFA5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Palmitoyltransferase PFA5</fullName>
            <ecNumber>2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Protein fatty acyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PFA5</name>
        <name type="ordered locus">CAGL0K06347g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448499.1">
        <property type="nucleotide sequence ID" value="XM_448499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMP5"/>
    <dbReference type="FunCoup" id="Q6FMP5">
        <property type="interactions" value="948"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMP5"/>
    <dbReference type="EnsemblFungi" id="CAGL0K06347g-T">
        <property type="protein sequence ID" value="CAGL0K06347g-T-p1"/>
        <property type="gene ID" value="CAGL0K06347g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890431"/>
    <dbReference type="KEGG" id="cgr:2890431"/>
    <dbReference type="CGD" id="CAL0133845">
        <property type="gene designation" value="CAGL0K06347g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06347g"/>
    <dbReference type="eggNOG" id="KOG1311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064801_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMP5"/>
    <dbReference type="OMA" id="YCVWIGT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF23">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000212976" description="Palmitoyltransferase PFA5">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="3">
        <location>
            <begin position="114"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="S-palmitoyl cysteine intermediate" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="352" mass="41128" checksum="2CB697C2D1096BF2" modified="2004-07-19" version="1">MGFAEWRLRNKYWTIYIVPLVVLLLMIYGTWAYCHKLCYERVYRDFGHKATAIGLICTCCVLDALIIAIWVLIVSCGPGHQPGVAPHLLVDSADLENTTVAPNCYQSDPHGYPVWCSNCQSLKVGRTKHSSHQGHCVPRFDHYCVWLGAVIGFKNYRLFVQFVFYFAVLLMIVWITISVYIRDIRQYHARLNANLIVLLIISGIGWLMTSGLFVSYIYYMSQNLTSIEVIDLKKRKRTPELSMQRLYCYYNSDDHYRYVVKLDNDFKGSVYKKHWLKNIKEFMGSNPMLWFIPLPQYWHESPLANGERDVNTIVSPYQEEVGPHTIDYIKKRIESGEYIHKFKEPGREKTHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMY0</accession>
    <name>Q6FMY0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0K04345g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448414.1">
        <property type="nucleotide sequence ID" value="XM_448414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMY0"/>
    <dbReference type="FunCoup" id="Q6FMY0">
        <property type="interactions" value="1275"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMY0"/>
    <dbReference type="KEGG" id="cgr:2889993"/>
    <dbReference type="CGD" id="CAL0134761">
        <property type="gene designation" value="CAGL0K04345g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04345g"/>
    <dbReference type="eggNOG" id="KOG2315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013809_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FMY0"/>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="229"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="479"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0134761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="647" mass="71776" checksum="9517F393717C9F69" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN10</accession>
    <name>Q6FN10_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K03663g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN10"/>
    <dbReference type="KEGG" id="cgr:2890134"/>
    <dbReference type="CGD" id="CAL0134607">
        <property type="gene designation" value="CAGL0K03663g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03663g"/>
    <dbReference type="eggNOG" id="ENOG502SBV3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162197_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN10"/>
    <dbReference type="OMA" id="VSWKYGV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="88" mass="8505" checksum="D108C29206CC270E" modified="2004-07-19" version="1">MSSSSRVSSSLSSMSSRVSSSIGTNSALVTNGAVAASSVAASANSTSSHKSSKTKNGAVSMIASPVSWKYGVAIGAFLAGSFVLGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN39</accession>
    <name>Q6FN39_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K03003g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN39"/>
    <dbReference type="KEGG" id="cgr:2890217"/>
    <dbReference type="CGD" id="CAL0134819">
        <property type="gene designation" value="CAGL0K03003g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03003g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_423339_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN39"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF67">
        <property type="entry name" value="FI01116P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="534"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="647" mass="71909" checksum="12F66896E2D7FA63" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN81</accession>
    <name>Q6FN81_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0K02013g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448313.1">
        <property type="nucleotide sequence ID" value="XM_448313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN81"/>
    <dbReference type="STRING" id="284593.Q6FN81"/>
    <dbReference type="KEGG" id="cgr:2890331"/>
    <dbReference type="CGD" id="CAL0134293">
        <property type="gene designation" value="CAGL0K02013g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02013g"/>
    <dbReference type="eggNOG" id="KOG2752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025221_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FN81"/>
    <dbReference type="OMA" id="DCGTERQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0134293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG61274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="372" mass="42598" checksum="6F44F71E3A41194D" modified="2004-07-19" version="1">MSSEGQGQTEEISASDFVNQQKQLEDEARELMPWEPKQCTYELGSIRQPVFACRSHNQIGICYSCSILCHTSCDIVELFTKRHFTCDCGTERDTKPADEDGIHCQLRKNRSKDISSDSNEYRQNFKGLFCGCSTEYDPENPAVMLQCVLGTECGEDWFHDYCILGKTKEEADELRARKQPDAENDDELEDPLAGMPDLETFDAFVCWKCTSKYEQYFKRLLSHPLSETVIAKQLYRQCSEVKETDDGKRKHDEGSEDYSLFLKKDHESAFKKILKSSEADSKIRIFLTDLAPHLIKDEPVYEPPEEKEETLSIEALTRQIIQNAMDRHTAVEGLTAFHSLKDKLNSFLAPFAEAGQTVKEEDIVTFFSKSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNF0</accession>
    <name>Q6FNF0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0K00451g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in 20S proteasome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the 20S proteasome chaperone.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNF0"/>
    <dbReference type="FunCoup" id="Q6FNF0">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNF0"/>
    <dbReference type="KEGG" id="cgr:2890187"/>
    <dbReference type="CGD" id="CAL0134145">
        <property type="gene designation" value="CAGL0K00451g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00451g"/>
    <dbReference type="eggNOG" id="KOG3112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062640_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FNF0"/>
    <dbReference type="OMA" id="PISWKGV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0134145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG61205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="268" mass="30383" checksum="3802241CE1B0618F" modified="2004-07-19" version="1">MTAKLIIPLIGTGNVPQLSIDLLLHSTNSFNYVKRIDSKFCYPFSGPLDHAAGEDPKLYNGKTLFSSAIELFKQKDEQIYVIQQRTPIIPGYLNNFIVETLIPVLHEYQITELIVLDSFGALDGVVESLNGSGSFFNVGTCNLSSVNDLIQQFDDHLNLRNNGQVNRVKAFNFDDKGIQQDITTEQDIFKVVYHLTNTSNLQLNKIKYYSTFVHEGDNSEDAYTFYNNLMLAQPEVFPRIDEFHPPVSWKGVYGFTPIRSAYDEGLYT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-02-21" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNL6</accession>
    <name>PPME1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein phosphatase methylesterase 1</fullName>
            <shortName>PME-1</shortName>
            <ecNumber>3.1.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PPE1</name>
        <name type="ordered locus">CAGL0J10736g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.89"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448178.1">
        <property type="nucleotide sequence ID" value="XM_448178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNL6"/>
    <dbReference type="SMR" id="Q6FNL6"/>
    <dbReference type="FunCoup" id="Q6FNL6">
        <property type="interactions" value="894"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNL6"/>
    <dbReference type="ESTHER" id="canga-ppme1">
        <property type="family name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0J10736g-T">
        <property type="protein sequence ID" value="CAGL0J10736g-T-p1"/>
        <property type="gene ID" value="CAGL0J10736g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889616"/>
    <dbReference type="KEGG" id="cgr:2889616"/>
    <dbReference type="CGD" id="CAL0133726">
        <property type="gene designation" value="CAGL0J10736g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J10736g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10736g"/>
    <dbReference type="eggNOG" id="KOG2564">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024818_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FNL6"/>
    <dbReference type="OMA" id="VMVCHHG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0719">Serine esterase</keyword>
    <feature type="chain" id="PRO_0000223662" description="Protein phosphatase methylesterase 1">
        <location>
            <begin position="1"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="386" mass="43659" checksum="5A173BF7D0736E70" modified="2004-07-19" version="1">MGDDLKRKILLHNLSSNNPILEKLKGGQEPNSNEEGSDSIGDLPSLKNDYKRQDNNSTNCTYIPPSQWNTYFRSNEHIKVQSRNIEFNTYYTVPSSILGPSLPVFIFHHGAGSSGLSFANLARNLGDQLNNNCCCLSFDARGHGGTKFIDAKQAQNYFRDDFVDDFHTLVEYFVSEKLKHLPTEKLSIIFIGHSLGGSICTFTYSKLSIELKKQVIGVAMFDIVEEAATLALEKVNHFLQVTPNMFSGYEEAIDWHVSHELSRLRESADIAIPALFKSTESGKVVRITNLETFRPFWRTWFSDLSKSFVSLPTCKLLILAGNDNLDRELIIGQMQGKYQLVVFQDSGHFIQEDTPRKTALTLVDFWKRNDNKNVVIKSNWGSSNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP79</accession>
    <name>Q6FP79_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0J05962g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP79"/>
    <dbReference type="FunCoup" id="Q6FP79">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP79"/>
    <dbReference type="KEGG" id="cgr:2889774"/>
    <dbReference type="CGD" id="CAL0133748">
        <property type="gene designation" value="CAGL0J05962g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05962g"/>
    <dbReference type="eggNOG" id="KOG3183">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052358_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FP79"/>
    <dbReference type="OMA" id="RQYCLKH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903843">
        <property type="term" value="P:cellular response to arsenite ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035617">
        <property type="term" value="P:stress granule disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0133748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="293" mass="32866" checksum="DCCB91C45D01A440" modified="2004-07-19" version="1">MFAKRAPQSVVNDMNNKEKETGMLDVGTHCQYCRQLDFLPFHCKLCDGDFCSEHRSKESHHCKWLLDHPEELENNGARSPPSSSKSNGGKFFQSLLPEKAHIRVKSPSPSSTTSQSPVKLGSSGVTTKNKPSETTKIRSTLNPAALNKLLNFFKRTKSDPKTKKKVSTSSNRLVELSTLKKTAKGDSKIPVQNRIYIYCQVILGEDETSDTLGLTKVPLYINKIWPVGRALDYLSQQLHVTNVNGNVDTTKGEKLFLYKYDEKLNEYVGIETSGRVNVLVKDLDTLYLVRGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPI8</accession>
    <name>Q6FPI8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL49</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0J03498g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL49 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPI8"/>
    <dbReference type="FunCoup" id="Q6FPI8">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPI8"/>
    <dbReference type="KEGG" id="cgr:2889697"/>
    <dbReference type="CGD" id="CAL0129709">
        <property type="gene designation" value="CAGL0J03498g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03498g"/>
    <dbReference type="eggNOG" id="KOG4034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132729_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FPI8"/>
    <dbReference type="OMA" id="TVETHSH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007740">
        <property type="entry name" value="Ribosomal_mL49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13477">
        <property type="entry name" value="MITOCHONDRIAL 39S RIBOSOMAL PROTEIN L49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05046">
        <property type="entry name" value="Img2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0129709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="123" mass="13945" checksum="7DE93C1EC93E59CE" modified="2004-07-19" version="1">MLSRVARRNGVFVRFQSSAVFPSVSEVRNDELVGHGSYTSKSYFVERSRVGNLPVYSDYRGGGNKVVTEIRRIRGNAVQLKKDLQAVLPHIPEKDWRVISQSNKIEIKGNYISELKSVLSETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPT4</accession>
    <name>Q6FPT4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vacuolar protein sorting-associated protein 53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0J01111g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPT4"/>
    <dbReference type="FunCoup" id="Q6FPT4">
        <property type="interactions" value="831"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPT4"/>
    <dbReference type="KEGG" id="cgr:2889852"/>
    <dbReference type="CGD" id="CAL0133148">
        <property type="gene designation" value="CAGL0J01111g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01111g"/>
    <dbReference type="eggNOG" id="KOG2180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358642_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPT4"/>
    <dbReference type="OMA" id="MINTADY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090156">
        <property type="term" value="P:intracellular sphingolipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="8">
        <location>
            <begin position="621"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0133148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="93981" checksum="E115DCD6A1D37389" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPU2</accession>
    <name>Q6FPU2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="13">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0J00913g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="13"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPU2"/>
    <dbReference type="FunCoup" id="Q6FPU2">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPU2"/>
    <dbReference type="KEGG" id="cgr:2889873"/>
    <dbReference type="CGD" id="CAL0132850">
        <property type="gene designation" value="CAGL0J00913g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J00913g"/>
    <dbReference type="eggNOG" id="KOG4718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_826927_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPU2"/>
    <dbReference type="OMA" id="KIIRINH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16493">
        <property type="entry name" value="RING-CH-C4HC3_NSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011513">
        <property type="entry name" value="Nse1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014857">
        <property type="entry name" value="Nse1_RING_C4HC3-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973">
        <property type="entry name" value="NON-SMC ELEMENT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20973:SF0">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07574">
        <property type="entry name" value="SMC_Nse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08746">
        <property type="entry name" value="zf-RING-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Non-structural maintenance of chromosomes element 1 RING C4HC3-type" evidence="15">
        <location>
            <begin position="325"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0132850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG60699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="378" mass="42859" checksum="29D161C0D2E49C3E" modified="2004-07-19" version="1">MSFKLIKSHLLHLKAIARSKKSNGVEVATQMSEGTPNNDVGDDLAGEVRIGLSESEKEKHLLQYLLNCRGVCHENVLLKVMLLMENEQGDLEQGLSVFEWQAKLQERVARINLKLQPLKYQVKKAIYGSGRAIVSEKVRSQLELNSANSFGKVNFPNSSQYYVYIDTSPFGEMKHATTFTDKELEYIKAFIKVLADRGSVIHEVDDVSGVDSKIVEQIDEIRQKAYGNKRRHDSDVESGPENAENNEPVQSSSVSRWTHYASYTADIAALTDTTDLQPLETQELLDKLCRLRWLYKTGKGKYGLDLRLLVEMNDYLSDNYSMSSCERCKDIVAQGVQCSTRDCNSVWHVDCYEHDILHENRICRSCGESILDRGVYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPZ1</accession>
    <name>Q6FPZ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ASN2</name>
        <name evidence="15 16" type="ordered locus">CAGL0I10648g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447703.1">
        <property type="nucleotide sequence ID" value="XM_447703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPZ1"/>
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        <property type="interactions" value="638"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPZ1"/>
    <dbReference type="GeneID" id="2889393"/>
    <dbReference type="KEGG" id="cgr:2889393"/>
    <dbReference type="CGD" id="CAL0130458">
        <property type="gene designation" value="ASN2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I10648g"/>
    <dbReference type="eggNOG" id="KOG0571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FPZ1"/>
    <dbReference type="OMA" id="GIVCAFD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:L-asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
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        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
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        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
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        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006949">
        <property type="entry name" value="PRK09431.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="367"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0130458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG60648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="574" mass="64710" checksum="BDB3E1D70CEF85F4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ24</accession>
    <name>Q6FQ24_CANGA</name>
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        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">CAGL0I09724g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG60607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="Q6FQ24"/>
    <dbReference type="FunCoup" id="Q6FQ24">
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    </dbReference>
    <dbReference type="KEGG" id="cgr:2888943"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ24"/>
    <dbReference type="OMA" id="FCCAVAV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032218">
        <property type="term" value="P:riboflavin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="83"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="497" mass="54687" checksum="66EC55C95FB427FD" modified="2004-07-19" version="1">MAFDSDVISVDKKAKGSSSEGNYLTRERTHQKDNETDSESDSEDIATVVRSNDSSDVESNYEEKPLNYSDVDDFPEGGLRAWTTVIGCFCGLVACFGLLNASGVVEDHVQQYQLANENPSTIGWIFSVFLFINFSSCIFSGTYFDRNGFRNPVILGGILHVAGLIATANCTKVWHFILAFSIVCGFGNGILIAPLVSVPAHYFNKRRGTALACATVGGSVGGVIFPVILRKFFTMKSTSDPNYGFVWGLRAWGLIDLFLLVIAVLMAKERLPNVVLTEEEKSVPTWKRVLKIYFMESFDAKAFLDMKYLFCVIGTVIGEFSLCATITYFASYSTAHGISESDAYMLIMVVNLVGILGRYIPGYLSDVIGRFNVAIITICGLGIVMLVGWLPFGTNLKNMYVISALYGFFSGSIFSLLPVCCGQISKTEEFGRRYSTMYFVVAFGTLIAVPVTGAIIGNESLQSYQHYVIFCGVTTLLCAVSFVISRYYCVGFKLVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ70</accession>
    <name>Q6FQ70_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0I08635g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ70"/>
    <dbReference type="FunCoup" id="Q6FQ70">
        <property type="interactions" value="61"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ70"/>
    <dbReference type="KEGG" id="cgr:2888992"/>
    <dbReference type="CGD" id="CAL0130047">
        <property type="gene designation" value="CAGL0I08635g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08635g"/>
    <dbReference type="eggNOG" id="KOG1659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045277_9_1_1"/>
    <dbReference type="InParanoid" id="Q6FQ70"/>
    <dbReference type="OMA" id="HICEKHP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017055">
        <property type="term" value="P:negative regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000036">
        <property type="entry name" value="CBF/NF-Y family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="3">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0130047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="139" mass="15404" checksum="8990C53B4F829636" modified="2004-07-19" version="1">MDIKEITTGDSEVYGTVGTEVGASVGASAEVSAEAKDETTEVFEKIKTHFPPAKVKKIMQSDEDIGKVSQATPVITGRSLEFFMALLVKKSGDMARQRGMKRITADVLRDTILEDERFDFLRESICAGYKGYKEDEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ94</accession>
    <name>Q6FQ94_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I08063g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ94"/>
    <dbReference type="FunCoup" id="Q6FQ94">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ94"/>
    <dbReference type="KEGG" id="cgr:2889289"/>
    <dbReference type="CGD" id="CAL0132196">
        <property type="gene designation" value="CAGL0I08063g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08063g"/>
    <dbReference type="eggNOG" id="KOG2688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048936_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ94"/>
    <dbReference type="OMA" id="PQLCSNI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="228"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="467" mass="53935" checksum="491BFCB3525517CF" modified="2004-07-19" version="1">MVNGYSLLDLVRDIGNGHLGVLSINIEKNGVRIAALQNDLQGQDDKMIDRLVDGSKIIMPGQDPTRRWTRLNIMVVSFLKFCRDVDPWSLWTSSDLIFEHYSNLNNALLDDSYPVDALTELFLSETEYVTKLAIKLDANNLDLGTKQSLFLSYISSIISKLFNSIKPPRDGANSTIPNKQLILLNIINKLNNIYFRINSPQLCSNIFKNFKPKSMFESFKRYPIHEQIEFRYLLGRYYVINFRMTNAFVQLDTAFRMLCQYMEQCPHTATREILQRNLKRILKYLIPVGITIGKKPHFQAVRGIDLDLAKSYIELSRNVNSGNFKQVNIWLASNEDELKSQNLLLPLLQKLPILVFRNLFRKVVIEYVLSAQNNKISYDLLMRALQVSIGSDQLALPPMFKVIHRPEDVENILVTLINLGFLRGNCFPALRLCVVKKTTDINDIFPEMTERIVKMFPLNNEDNWFDI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQA0</accession>
    <name>REXO4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>RNA exonuclease 4</fullName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">REX4</name>
        <name type="ordered locus">CAGL0I07931g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the REXO4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447594.1">
        <property type="nucleotide sequence ID" value="XM_447594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQA0"/>
    <dbReference type="SMR" id="Q6FQA0"/>
    <dbReference type="FunCoup" id="Q6FQA0">
        <property type="interactions" value="859"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQA0"/>
    <dbReference type="EnsemblFungi" id="CAGL0I07931g-T">
        <property type="protein sequence ID" value="CAGL0I07931g-T-p1"/>
        <property type="gene ID" value="CAGL0I07931g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889234"/>
    <dbReference type="KEGG" id="cgr:2889234"/>
    <dbReference type="CGD" id="CAL0132752">
        <property type="gene designation" value="CAGL0I07931g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I07931g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07931g"/>
    <dbReference type="eggNOG" id="KOG2249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022453_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FQA0"/>
    <dbReference type="OMA" id="TMLIYKS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000131693" description="RNA exonuclease 4">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuclease">
        <location>
            <begin position="95"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="263" mass="29970" checksum="B987A5B1229D64A4" modified="2004-07-19" version="1">MRLSSNWSKLQDGVTKKAGKKRIDKKPHIIKKVGQDKKPKSKIMGMIYQMNKEIDQQKENKKVGKKFEFTETITEIDTVETTTETKKDANKIGKYIAMDCEFVGVGPEGKDSALARVSLVNFHGNVVLDIFVKPRETVTDWRTWVSGITPDHMKNAVSFKQAQQQLSDILKDKILVGHAVKHDLEALMLSHPKSKVIDTARHLPFRQKYAKGKSPSLKKLAKEILNMDIQSGQHSSVEDARATMLIYKSAKQDFDKEHRKKFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQB4</accession>
    <name>Q6FQB4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0I07623g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 15">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQB4"/>
    <dbReference type="FunCoup" id="Q6FQB4">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQB4"/>
    <dbReference type="KEGG" id="cgr:2888979"/>
    <dbReference type="CGD" id="CAL0132176">
        <property type="gene designation" value="CAGL0I07623g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07623g"/>
    <dbReference type="eggNOG" id="KOG2108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_7_0_1"/>
    <dbReference type="InParanoid" id="Q6FQB4"/>
    <dbReference type="OMA" id="ENGWRGL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF46">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE HMI1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="10">
        <location>
            <begin position="7"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="11">
        <location>
            <begin position="285"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0132176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="711" mass="81249" checksum="03F57ED1EB0D547E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQD8</accession>
    <name>Q6FQD8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PHO85 cyclin CLG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I07051g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQD8"/>
    <dbReference type="FunCoup" id="Q6FQD8">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQD8"/>
    <dbReference type="KEGG" id="cgr:2889184"/>
    <dbReference type="CGD" id="CAL0132304">
        <property type="gene designation" value="CAGL0I07051g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07051g"/>
    <dbReference type="eggNOG" id="ENOG502RYK1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034017_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQD8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="448" mass="51845" checksum="FFEDD41DC6FA1DBC" modified="2004-07-19" version="1">MAYNYLQDPVLFNQGPQVVSHHTHSQSMNLLPSLSHPAHHRHNTYSQQQMMSMMPIQQNAIYQPVMPLDQTQMHIPKMIVQDQFLPPQPQPQPPQEQVNGGVSHVLDYDVEIMTQFVMKNAFFAFRTPVNDNINNTTLFTKGIISVLNATRLPSVTIYLAIDYLFKYINKLADGPNTIGGNSINVIYQNTMIAFILANKFNDDKTFTNKSWSQATGMSIKIINDYERDWLKTFEWKLFDDKFILYPEFVAAYKLFEEETRRDQYELQQQQQQQSPMLQPKPSSTNNYLPPSIGTSTYEFGYQTPLTMYSSPTNFFYQSMPSKNDYGNEVDPYQQNYIPPAMPLVSPLSDVGRVSARDEFADNSFDYDFYNFGTNQTNNTMNYKVNSKGNLQPSQAFFSNADGYHMNQPYYQQNSDITTLNMMLQHQQYNKPLYSSNLNQNCFPYSAVY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQT7</accession>
    <name>ATG9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ATG9</name>
        <name type="ordered locus">CAGL0I03652g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Required for mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer. Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of ATG9-containing vesicles, thereby enabling growth into autophagosomes.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2">Phosphorylated by ATG1. ATG1 phosphorylation is required for preautophagosome elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447407.1">
        <property type="nucleotide sequence ID" value="XM_447407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQT7"/>
    <dbReference type="SMR" id="Q6FQT7"/>
    <dbReference type="FunCoup" id="Q6FQT7">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQT7"/>
    <dbReference type="GlyCosmos" id="Q6FQT7">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0I03652g-T">
        <property type="protein sequence ID" value="CAGL0I03652g-T-p1"/>
        <property type="gene ID" value="CAGL0I03652g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889146"/>
    <dbReference type="KEGG" id="cgr:2889146"/>
    <dbReference type="CGD" id="CAL0132556">
        <property type="gene designation" value="CAGL0I03652g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03652g"/>
    <dbReference type="eggNOG" id="KOG2173">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006200_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQT7"/>
    <dbReference type="OMA" id="IAEWKFR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061908">
        <property type="term" value="C:phagophore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017128">
        <property type="term" value="F:phospholipid scramblase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0445">Lipid transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000119827" description="Autophagy-related protein 9">
        <location>
            <begin position="1"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="5">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="367"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="intramembrane region" evidence="1">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="529"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="5">
        <location>
            <begin position="610"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="647"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="intramembrane region" evidence="1">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="5">
        <location>
            <begin position="714"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="755"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O74312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q12142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="928" mass="107241" checksum="F109069B62ED81D6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRD0</accession>
    <name>Q6FRD0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0H09548g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRD0"/>
    <dbReference type="MEROPS" id="T01.984"/>
    <dbReference type="KEGG" id="cgr:2888716"/>
    <dbReference type="CGD" id="CAL0132008">
        <property type="gene designation" value="CAGL0H09548g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09548g"/>
    <dbReference type="eggNOG" id="KOG0177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_12_0_1"/>
    <dbReference type="InParanoid" id="Q6FRD0"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0132008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="194" mass="21961" checksum="BC3CEBEE28B1730B" modified="2004-07-19" version="1">MDIILGIRVQDSVILATSKAVTRGISVLKDSDDKSRLLSPHTLMTFTGEAGDTVQFAEYIQANMQLYSIRENYELSPSAVSSYVRQELAKSIRSRKPYQVNVLIGGYDTKKEKPELYQIDYLGTKVDLPYAAHGYSGFYTFSLLDHHYRPDMTTTEGLELLKLCIAELQKRMPIDFKGVIVKIVDKDGVREVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRG1</accession>
    <name>Q6FRG1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Stress protein DDR48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H08844g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRG1"/>
    <dbReference type="STRING" id="284593.Q6FRG1"/>
    <dbReference type="KEGG" id="cgr:2888677"/>
    <dbReference type="CGD" id="CAL0132038">
        <property type="gene designation" value="CAGL0H08844g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08844g"/>
    <dbReference type="eggNOG" id="ENOG502QUR8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_416764_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRG1"/>
    <dbReference type="OMA" id="WGTNDND"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="365"/>
        </location>
    </feature>
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        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="478"/>
        </location>
    </feature>
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        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60116.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="70888" checksum="C957B847C6115A4E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRG3</accession>
    <name>Q6FRG3_CANGA</name>
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        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0H08800g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG60114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRG3"/>
    <dbReference type="KEGG" id="cgr:2888741"/>
    <dbReference type="CGD" id="CAL0130416">
        <property type="gene designation" value="CAGL0H08800g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08800g"/>
    <dbReference type="eggNOG" id="KOG4093">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="Q6FRG3"/>
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        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990593">
        <property type="term" value="F:nascent polypeptide-associated complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061770">
        <property type="term" value="F:translation elongation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="17"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0130416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="148" mass="17683" checksum="5D160EA5BFFA0234" modified="2004-07-19" version="1">MSLNTFDPNTAENSEDIEKQFAVVAVEQAETYWKLITSIPGSKLRLTKLDDEIYELFMERFPEYKDIERLRKFDEEELKNKVAKERWRQFANYFEKKVEDFNFGTLLRTDANAEYGQFTTCFVVRIQFYAFEIARNRHGLNDWAVGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRI6</accession>
    <name>Q6FRI6_CANGA</name>
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        <recommendedName>
            <fullName evidence="5">UspA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H08261g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447158.1">
        <property type="nucleotide sequence ID" value="XM_447158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRI6"/>
    <dbReference type="FunCoup" id="Q6FRI6">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRI6"/>
    <dbReference type="KEGG" id="cgr:2888445"/>
    <dbReference type="CGD" id="CAL0131992">
        <property type="gene designation" value="CAGL0H08261g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08261g"/>
    <dbReference type="eggNOG" id="ENOG502RISH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012887_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRI6"/>
    <dbReference type="OMA" id="WRRTENL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="687"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="83124" checksum="5B1A72C771689188" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRM1</accession>
    <name>AMN1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Antagonist of mitotic exit network protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AMN1</name>
        <name type="ordered locus">CAGL0H07491g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negative regulator of the mitotic exit network (MEN), required for multiple cell cycle checkpoints. Required for daughter cell separation and chromosome stability. Involved in copper sensitivity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AMN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447123.1">
        <property type="nucleotide sequence ID" value="XM_447123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRM1"/>
    <dbReference type="SMR" id="Q6FRM1"/>
    <dbReference type="FunCoup" id="Q6FRM1">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRM1"/>
    <dbReference type="EnsemblFungi" id="CAGL0H07491g-T">
        <property type="protein sequence ID" value="CAGL0H07491g-T-p1"/>
        <property type="gene ID" value="CAGL0H07491g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888591"/>
    <dbReference type="KEGG" id="cgr:2888591"/>
    <dbReference type="CGD" id="CAL0131776">
        <property type="gene designation" value="CAGL0H07491g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07491g"/>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031725_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FRM1"/>
    <dbReference type="OMA" id="IGLAGCH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001042">
        <property type="term" value="P:negative regulation of septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032984">
        <property type="term" value="P:protein-containing complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09293">
        <property type="entry name" value="AMN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF247">
        <property type="entry name" value="GH16156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0498">Mitosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000277843" description="Antagonist of mitotic exit network protein 1">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P38285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="511" mass="58085" checksum="648056C6D07B325D" modified="2004-07-19" version="1">MVLPDSNIMKNGSIKRLRDSQIENSPYSRPIKKITPNSSHEDLSATISNEGSLNFTPRTSRQESLYNMKKIFQKTYSQTKLGLFSSKKQVNTLETAIPTTPKQQLPTPTTSPEKNNILWSTPNSLTSLRTISNDLDDCRNRNLITDFSELSIINSSSSSIYSTQQSHPIFEIPEIVDNIVKQLYLIENEQDLLNGHHKKDVNRENTSTVVSCLAVSKTWNKVSKGYLMRDLKFTKSTSLTNFLSQCSTKKTTPQSLILHKMSDINNNNSRGLEIIIDPKQLRHLEYYVCPNILPPVNWFQSLTKLEKLILPGNKLINDSYLIQICRYLPNLKVLDLRACDNITDAGIVAVGTHCKQLVSCNIGRHRNGSSITGLSVVALAKNTMIRTLGLAGCDITDASMWELAQKCGKNIERLSLNNCNKLTNFSLPMLFAFNYFPNLNVLEIQNIAKITDVRHMVRYKIWKRSQRIPILIKGCDRITKLIHEEERQIKAQSLKTARKDMTLWVNQLENE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRY5</accession>
    <name>SLU7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SLU7</name>
        <name type="ordered locus">CAGL0H04917g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447009.1">
        <property type="nucleotide sequence ID" value="XM_447009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRY5"/>
    <dbReference type="SMR" id="Q6FRY5"/>
    <dbReference type="FunCoup" id="Q6FRY5">
        <property type="interactions" value="562"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRY5"/>
    <dbReference type="EnsemblFungi" id="CAGL0H04917g-T">
        <property type="protein sequence ID" value="CAGL0H04917g-T-p1"/>
        <property type="gene ID" value="CAGL0H04917g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888505"/>
    <dbReference type="KEGG" id="cgr:2888505"/>
    <dbReference type="CGD" id="CAL0132000">
        <property type="gene designation" value="CAGL0H04917g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04917g"/>
    <dbReference type="eggNOG" id="KOG2560">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072877_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRY5"/>
    <dbReference type="OMA" id="KSKMFRR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000386">
        <property type="term" value="F:second spliceosomal transesterification activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000218545" description="Pre-mRNA-splicing factor SLU7">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="318" mass="37458" checksum="CAE5630671B1DFCB" modified="2004-07-19" version="1">MHNKKVTKDEKKNTKTKDVNEHIPNYIKNLPWYYQDIDKNSKNNSKEQDYLRHHRQRRDDKTIDIDNNDQAKIGTGIKDEFEVIVENKKTTIDGIIKRRKDEKDWDARKDRWYGYSGKEYEEVLKKWEKSREDLNNTTEESAYDTDEEIEMMKLGLTPKDLEQNIKGSSVRLREDKAAYLKDIYSSTTNYDPKSRLYKSDDLGSIDEHSNMFLRHLTGEGKELNDLNKFARENAKESGIRDELVDADKVNHVLVANPTKLEVLRKQKELDSLKLTEEQNRQEQRKLKRKAKLLKKKAKKPKGTPQSDSTKAQLMDMYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSE9</accession>
    <name>Q6FSE9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0H01045g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSE9"/>
    <dbReference type="FunCoup" id="Q6FSE9">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888442"/>
    <dbReference type="CGD" id="CAL0129707">
        <property type="gene designation" value="CAGL0H01045g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01045g"/>
    <dbReference type="eggNOG" id="KOG2861">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011220_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSE9"/>
    <dbReference type="OMA" id="QGLYQTK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="111"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0129707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="361" mass="40947" checksum="88123CECE316FC29" modified="2004-07-19" version="1">MTNIDSYGVKTTKFTKGIANPTRYLRRSFVPRSKKVNAVDTESEDDKFESSILKTLVIKPCTTVTTGERYDLGKCLEILNINGFQPSNLIPGEIVSFNYRTNGIDGTIMILGQTGSVVCWGVDERTALIEIVPLISEAIVNKLEVEEYETEDMDYIEIESAEDLENLRSHSGIQSEPKINSRLIGDVILINSIEKSEGILDKAAFSSGLSRSTALAVLENAMERHISNTRIITEKISTGIKLKVKESDALKSIGRLFLIRGRLNLYSELIETPDLYWSEPELEIIFKDVSRYLDISPRINILNSKLDYSTDECRAILSLLNERNSSFLEWIIIYLITFEVIFELFHFYKSNQESTKRVEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSI1</accession>
    <name>Q6FSI1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H00352g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446813.1">
        <property type="nucleotide sequence ID" value="XM_446813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSI1"/>
    <dbReference type="KEGG" id="cgr:2888804"/>
    <dbReference type="CGD" id="CAL0130559">
        <property type="gene designation" value="CAGL0H00352g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00352g"/>
    <dbReference type="HOGENOM" id="CLU_748018_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSI1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="370" mass="42415" checksum="9D9747DBDC1CE208" modified="2004-07-19" version="1">MDDEFGPIRKSLKKVSVGSITQSNYDTDDLCTTEIIPLQKRPRHAPNVLDTPFAIVNYPCIVTDDNRKDTYATELFYEQVLFKTFRYKLLDNLLQNQLEFAPALNQIAKSLYKLVIKSFNKELTTVKNYRIVAPEVSSSRFTSNIIDNVVVFDTVASKHFNLINIRLESPEGLQAKDVSRIHRFLKKSYPIDEVPMQSEGLNGFKNIIDYFTKLNSTAIMRSLKPLHFKIDIFQYNYDVEKITNIIPTKPNFKIIISTIGSSHSLDDNPITTIVNLSELSDINLSRMCQQALHCKCDMGKHTGLKEYQDLWNHCVADITQNKLGSNNLFHLFLVSFTIGGLGTNFFFYLEQTLNGVRSMDQLLRNFGINR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSM8</accession>
    <name>FYV8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein FYV8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">FYV8</name>
        <name type="ordered locus">CAGL0G09295g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the resistance to unfolded protein response (UPR)-inducing agents.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FYV8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446766.1">
        <property type="nucleotide sequence ID" value="XM_446766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSM8"/>
    <dbReference type="FunCoup" id="Q6FSM8">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSM8"/>
    <dbReference type="EnsemblFungi" id="CAGL0G09295g-T">
        <property type="protein sequence ID" value="CAGL0G09295g-T-p1"/>
        <property type="gene ID" value="CAGL0G09295g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888051"/>
    <dbReference type="KEGG" id="cgr:2888051"/>
    <dbReference type="CGD" id="CAL0129928">
        <property type="gene designation" value="CAGL0G09295g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G09295g"/>
    <dbReference type="eggNOG" id="ENOG502QPM9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009686_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSM8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026248">
        <property type="entry name" value="Fyv8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02076">
        <property type="entry name" value="PROTEINFYV8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000292480" description="Protein FYV8">
        <location>
            <begin position="1"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="20"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="767" mass="85593" checksum="5E73E12D71729FFC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSS0</accession>
    <name>GPN3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GPN-loop GTPase 3</fullName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAGL0G08294g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Small GTPase involved in the correct assembly of RNA polymerase II and III (RNAPII and RNAPIII) complexes, ensuring their proper nuclear import of RNAPII. Promotes sister chromatid separation during anaphase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSS0"/>
    <dbReference type="SMR" id="Q6FSS0"/>
    <dbReference type="FunCoup" id="Q6FSS0">
        <property type="interactions" value="942"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSS0"/>
    <dbReference type="EnsemblFungi" id="CAGL0G08294g-T">
        <property type="protein sequence ID" value="CAGL0G08294g-T-p1"/>
        <property type="gene ID" value="CAGL0G08294g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888203"/>
    <dbReference type="CGD" id="CAL0129289">
        <property type="gene designation" value="CAGL0G08294g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_G08294g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08294g"/>
    <dbReference type="eggNOG" id="KOG1534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSS0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52071">
        <property type="entry name" value="GPN_LOOP_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000255589" description="GPN-loop GTPase 3">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="GPN-loop core GTPase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="G1" evidence="4">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="G2" evidence="4">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Gly-Pro-Asn (GPN)-loop; involved in dimer interface" evidence="3 4">
        <location>
            <begin position="70"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="G3" evidence="4">
        <location>
            <begin position="104"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="G4" evidence="4">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="G5" evidence="4">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="site" description="Stabilizes the phosphate intermediate; shared with dimeric partner" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P47122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q06543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q9UYR9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="271" mass="30565" checksum="C1693012F187AF43" modified="2004-07-19" version="1">MSRVGLLVLGPAGAGKSTFCNSIISHMQTIGRRAHIVNLDPAAEPSKYEFTIDIRDLISLDDVMEELDLGPNGALIYCFEYLMKNLDWLDEEIGDYNDEYLIFDCPGQIELYTHIPVLPNIVRHLQGQLNFNLCATYLLEAPFVIDSSKFFSGALSAMSAMILLELPHINVLSKLDMIKDEYGKKKLKRFLNPDAMLLANEADQNLNPKFHHLNQCIANLVDDFGMVQFLPLEANNPESVATILSYVDDVTQWAEAQEQKEPKDQIDIEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSY4</accession>
    <name>Q6FSY4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Skg3/CAF120-like PH-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G06886g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSY4"/>
    <dbReference type="FunCoup" id="Q6FSY4">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888431"/>
    <dbReference type="CGD" id="CAL0129710">
        <property type="gene designation" value="CAGL0G06886g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06886g"/>
    <dbReference type="eggNOG" id="ENOG502QTIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017094_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FSY4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Skg3/CAF120-like PH-like" evidence="2">
        <location>
            <begin position="459"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="696" mass="78107" checksum="81065DA44A547A4E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSZ0</accession>
    <name>Q6FSZ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division control protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0G06754g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="cgr:2888234"/>
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        <property type="gene designation" value="CAGL0G06754g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06754g"/>
    <dbReference type="eggNOG" id="KOG1547">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="InParanoid" id="Q6FSZ0"/>
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        <property type="component" value="Chromosome G"/>
    </dbReference>
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        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:mating projection base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:mating projection septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036391">
        <property type="term" value="C:medial cortex septin ring"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032152">
        <property type="term" value="C:meiotic septin complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072687">
        <property type="term" value="C:meiotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032151">
        <property type="term" value="C:mitotic septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:prospore membrane"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032169">
        <property type="term" value="C:prospore septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032160">
        <property type="term" value="C:septin filament array"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070583">
        <property type="term" value="P:spore membrane bending pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="8">
        <location>
            <begin position="30"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0129332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="324" mass="37179" checksum="B6468F1CDACC3EEA" modified="2004-07-19" version="1">MSTIPEALLPSNYVGFDTITSQIEHRLLKRGFQFNIMVVGHSGLGKSTLINTLFSSHLIDPATGEDISKQPITKTTEMKVSSHTLIEDRVRLNINIIDTPGFGDNINNNKVWEPIVKYIKEQYSQYLRKELTAQRDRYIPDTRVHAILYFLQPNGKGLTALDVATLKRLTEIANVIPVIAKADTLTIDERTKFKKIIQSEFEKYNFRIYPYDSDDLTEDELVLNKSIRSVIPFAVVGSEKEIEVNGETFRGRKSRWGAINVEDINQCDFVYLREYLIRTHLQDLIETTSFVHYEGFRSRQLIALKENANNRASSQMGGNQPYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSZ5</accession>
    <name>Q6FSZ5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0G06644g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_446649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSZ5"/>
    <dbReference type="STRING" id="284593.Q6FSZ5"/>
    <dbReference type="KEGG" id="cgr:2888053"/>
    <dbReference type="CGD" id="CAL0130548">
        <property type="gene designation" value="CAGL0G06644g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06644g"/>
    <dbReference type="HOGENOM" id="CLU_2096569_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSZ5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0130548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="116" mass="12409" checksum="6506E924D29E163C" modified="2004-07-19" version="1">MPNFTGALCNYTISTVVPQTTDCSLPALLLPFSLPRRPSGGPRTTRARIRPTLHSGGTIATASSLLLEAKKANSTDRSPGTPQENTAAPCGIITKRLNSFASVNFLANYTQRHPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT08</accession>
    <name>Q6FT08_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G06314g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT08"/>
    <dbReference type="FunCoup" id="Q6FT08">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888419"/>
    <dbReference type="CGD" id="CAL0130509">
        <property type="gene designation" value="CAGL0G06314g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06314g"/>
    <dbReference type="eggNOG" id="ENOG502RZP4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428390_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT08"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025752">
        <property type="entry name" value="HPH_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13694">
        <property type="entry name" value="Hph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0130509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="653" mass="73810" checksum="79DC2BD83760301A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT14</accession>
    <name>Q6FT14_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0G06160g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446630.1">
        <property type="nucleotide sequence ID" value="XM_446630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT14"/>
    <dbReference type="KEGG" id="cgr:2888111"/>
    <dbReference type="CGD" id="CAL0130747">
        <property type="gene designation" value="CAGL0G06160g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06160g"/>
    <dbReference type="HOGENOM" id="CLU_2426788_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT14"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0130747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="91" mass="10751" checksum="DB565689441F16E7" modified="2004-07-19" version="1">MLSQLQSMKSKLKKKGFHFFREVKGETEITSVDKSLHAQYHKQNPILVYIIFNPWELKAAPATQEWRHFAEFVPYTLSLDSENHIYLTIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT53</accession>
    <name>Q6FT53_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositolphosphotransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">IPT1</name>
        <name evidence="3 4" type="ordered locus">CAGL0G05313g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT53"/>
    <dbReference type="FunCoup" id="Q6FT53">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT53"/>
    <dbReference type="KEGG" id="cgr:2888164"/>
    <dbReference type="CGD" id="CAL0130251">
        <property type="gene designation" value="IPT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05313g"/>
    <dbReference type="eggNOG" id="ENOG502QPKA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047580_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FT53"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF8">
        <property type="entry name" value="INOSITOLPHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0130251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="59944" checksum="E8424FC1076ED7CF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTG7</accession>
    <name>Q6FTG7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G02629g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTG7"/>
    <dbReference type="FunCoup" id="Q6FTG7">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTG7"/>
    <dbReference type="KEGG" id="cgr:2888401"/>
    <dbReference type="CGD" id="CAL0129180">
        <property type="gene designation" value="CAGL0G02629g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02629g"/>
    <dbReference type="eggNOG" id="KOG4174">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035438_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTG7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="71"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="323" mass="37623" checksum="252112F9728A8EFF" modified="2004-07-19" version="1">MARRLKGKGGAKGLKAALLNHKANVQQNKVLKKKTENKIKQKTQLNKNQKKQQQNSVEKSFIPFEKNETLMLVGEGDFSFARSIIEESYILPENLIVTSYDNSYNELKLKYPHSFEENFKFLVDNNVKILYQVDATKLIKSLKLSKHTPWSKLMGPSWKFKYLQNIMFNFPHTGKGVKDQDRNIRDHQELLFGFFDSAKQLYSLVNSNKKNLEVGQTMGYNLSNNHDAKSNITEEGYGRIILSLFTGEPYDSWSIKILAKNNGLQLERSNKFQWENFPQYSHKRTNSEQDTTKPAKERDARIYIFKKYEKTKPKKVSEDSDEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTK4</accession>
    <name>RL11_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Large ribosomal subunit protein uL5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>60S ribosomal protein L11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPL11</name>
        <name type="ordered locus">CAGL0G01826g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTK4"/>
    <dbReference type="SMR" id="Q6FTK4"/>
    <dbReference type="FunCoup" id="Q6FTK4">
        <property type="interactions" value="1124"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTK4"/>
    <dbReference type="EnsemblFungi" id="CAGL0G01826g-T">
        <property type="protein sequence ID" value="CAGL0G01826g-T-p1"/>
        <property type="gene ID" value="CAGL0G01826g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888415"/>
    <dbReference type="CGD" id="CAL0137763">
        <property type="gene designation" value="CAGL0G01826g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_G01826g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01826g"/>
    <dbReference type="eggNOG" id="KOG0397">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FTK4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_uL5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000125101" description="Large ribosomal subunit protein uL5">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0C0W9"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="174" mass="19846" checksum="1F34E3CB68EDA431" modified="2004-07-19" version="1">MSAKTQNVMRELKIEKLVLNISVGESGDRLTRASKVLEQLSGQTPVQSKARYTVRTFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYQLRNRNFSTTGNFGFGIQEHIDLGIKYDPSIGIFGMDFYIVMGRPGNRIARRKRCRATVGNSHKTSKEDTIAWFKQRYDADVLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTM3</accession>
    <name>Q6FTM3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0G01364g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTM3"/>
    <dbReference type="FunCoup" id="Q6FTM3">
        <property type="interactions" value="1190"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTM3"/>
    <dbReference type="KEGG" id="cgr:2888007"/>
    <dbReference type="CGD" id="CAL0130141">
        <property type="gene designation" value="CAGL0G01364g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01364g"/>
    <dbReference type="eggNOG" id="KOG2298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTM3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000002">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="200"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0130141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG59348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="663" mass="74962" checksum="8403FE4F2006B5B5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTP6</accession>
    <name>Q6FTP6_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G00836g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446398.1">
        <property type="nucleotide sequence ID" value="XM_446398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTP6"/>
    <dbReference type="KEGG" id="cgr:2888243"/>
    <dbReference type="CGD" id="CAL0129365">
        <property type="gene designation" value="CAGL0G00836g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00836g"/>
    <dbReference type="HOGENOM" id="CLU_1948557_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTP6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="129" mass="15208" checksum="F375FE7F8BBEECF9" modified="2004-07-19" version="1">MKYNININLTHSKAASRPTHVYLYNTYIYLCCAIPWIRSLRSSTCDLISYRPVTKVSNAKRDSAKEKREKRFQLSGLRIELIRAKLLRNECTMGGGSWYQKSQFQLRKPSFTCFGYWFVGLQERTWHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTR6</accession>
    <name>Q6FTR6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Family 17 glucosidase SCW4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SCW4</name>
        <name evidence="16 17" type="ordered locus">CAGL0G00308g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446378.1">
        <property type="nucleotide sequence ID" value="XM_446378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTR6"/>
    <dbReference type="FunCoup" id="Q6FTR6">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTR6"/>
    <dbReference type="CAZy" id="GH17">
        <property type="family name" value="Glycoside Hydrolase Family 17"/>
    </dbReference>
    <dbReference type="GeneID" id="2888414"/>
    <dbReference type="KEGG" id="cgr:2888414"/>
    <dbReference type="CGD" id="CAL0130484">
        <property type="gene designation" value="SCW4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00308g"/>
    <dbReference type="eggNOG" id="ENOG502QTKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027285_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTR6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000111">
        <property type="entry name" value="Soluble cell wall protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF14">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274191" description="Family 17 glucosidase SCW4" evidence="15">
        <location>
            <begin position="18"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="64"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0130484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG59305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="39449" checksum="7FC1B0E0A911F59C" modified="2004-07-19" version="1">MKFSTLITSALLGTAIAAPHAAHTHKEKRDVVTKTMHAVQTVVVGPDGTPVQKAEAINEQVVENAPQPTTQQQQQQQQQASPAPAKSTTELAPASSPASSSSSSSSSNTKKPDTQVGGAGVKGITYTPYNADGTCKDASAVASDLAALSQYPTIRLYGTDCNQVENVFKAKASGQKLFLGVFDVSNIQGSVDAIKSAVNTYGSWDDVTTVSIGNELVNGGQASPAQVGQYVAAGRAALQAAGFNGPVVSVDTFIAVINNPELCQYSEYMAVNAHAYFDQYTKAQDAGSWLLQQIQRVWTACDGKKEVVITESGWPSKGQTLGVAVPSKQNQKDAVNSITAACGADTFLYNAFNDYWKADGPYGCEKYWGVLSDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTT0</accession>
    <name>SET5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Histone-lysine N-methyltransferase SET5</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SET5</name>
        <name type="ordered locus">CAGL0F09119g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that monomethylates 'Lys-5', 'Lys-8' and 'Lys-12' of histone H4 (H4K5me1, H4K8me1 and H4K12me1, respectively), thereby controlling gene expression and remodeling chromatin structures.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446364.1">
        <property type="nucleotide sequence ID" value="XM_446364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTT0"/>
    <dbReference type="FunCoup" id="Q6FTT0">
        <property type="interactions" value="728"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTT0"/>
    <dbReference type="EnsemblFungi" id="CAGL0F09119g-T">
        <property type="protein sequence ID" value="CAGL0F09119g-T-p1"/>
        <property type="gene ID" value="CAGL0F09119g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887694"/>
    <dbReference type="KEGG" id="cgr:2887694"/>
    <dbReference type="CGD" id="CAL0129802">
        <property type="gene designation" value="SET5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_F09119g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F09119g"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031650_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTT0"/>
    <dbReference type="OMA" id="CEPNVRY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd08161">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000324466" description="Histone-lysine N-methyltransferase SET5">
        <location>
            <begin position="1"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="114"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P38890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="515" mass="58984" checksum="D7838E98B613ECE8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTU6</accession>
    <name>Q6FTU6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0F08723g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTU6"/>
    <dbReference type="FunCoup" id="Q6FTU6">
        <property type="interactions" value="594"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTU6"/>
    <dbReference type="KEGG" id="cgr:2887575"/>
    <dbReference type="CGD" id="CAL0131344">
        <property type="gene designation" value="CAGL0F08723g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08723g"/>
    <dbReference type="eggNOG" id="KOG2803">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031246_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTU6"/>
    <dbReference type="OMA" id="FESNNWV"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0131344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="316" mass="36072" checksum="09F4869417681408" modified="2004-07-19" version="1">MTVHLWEEKVWIDGCFDFTHHGHAGVFLQARQTIDPEVSGGNDALICGIHSDEDIRVNKGCLPVMQERERYEHARANRWCDQVIEGAPYVTHPDVMNKYGCMYVVHGDDITLDKDGNDCYQEMKDCGRYKCVKRTAGVSTSDIIQRILTGSRDHHSRPDEVVTLEELTKYSYDRDGYGPGCTVYRETLDNIVVRGKTVPERLVIVEGNFDLFHIGHISKFKKIRADHPDRHVIVSVRTNEDDIMTLKEKALSILSCKYIDGVVLDLDMGTLATDIVTIQIDDIDGGEFDYLTKETIVNRIISQRDEYVSRNKRKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTV9</accession>
    <name>Q6FTV9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Steryl acetyl hydrolase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0F08437g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTV9"/>
    <dbReference type="FunCoup" id="Q6FTV9">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTV9"/>
    <dbReference type="ESTHER" id="canga-q6ftv9">
        <property type="family name" value="Steryl_acetyl_hydrolase"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887630"/>
    <dbReference type="CGD" id="CAL0131166">
        <property type="gene designation" value="CAGL0F08437g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08437g"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067868_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTV9"/>
    <dbReference type="OMA" id="AISPWAN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034084">
        <property type="term" value="F:steryl deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019436">
        <property type="entry name" value="Say1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10340">
        <property type="entry name" value="Say1_Mug180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="48246" checksum="CAD7CE3FCAF1EBDD" modified="2004-07-19" version="1">MDTKSNVSVNTTEIPTNITVTTDLSTLRNEEDSITMSIWHTLRFLSKFIGILPFKMTYYLIKVVMESERGVNIDIVSRIFMRESTKLIDENICQYVLNPIFEFIYKFEGNGISLINYSVPNDDLEQISGGIFDKPFVKSTRTQSKFFWKRQINPHTFNPEIDPILIYYHGGGYALQLTPTTLSFLTNTGKYFPDMPILISDYATTASKLDSNKYPRQLLDILAVYDYVTQSLGCKNVIVMGDSAGGNAVLVLLLYLHKHNRPLLPRKAIPISPWLNTTYIGEQERTYMKQSEKWDGICTKGSEMFGDLYIPKILRESGYNPDNDEYINIEHNFDAETWNLITEKCDLLVTYGDDEILSYQIKLFVDKLIECNPKRYNNVENVLAHFQGCHTGPILAWDGNVESWSKQTMIKPILDFIDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU09</accession>
    <name>Q6FU09_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">5'-AMP-activated protein kinase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0F07315g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (SNF1) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU09"/>
    <dbReference type="FunCoup" id="Q6FU09">
        <property type="interactions" value="490"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU09"/>
    <dbReference type="KEGG" id="cgr:2887662"/>
    <dbReference type="CGD" id="CAL0131404">
        <property type="gene designation" value="CAGL0F07315g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07315g"/>
    <dbReference type="eggNOG" id="KOG1764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021740_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FU09"/>
    <dbReference type="OMA" id="TASIHPF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030447">
        <property type="term" value="P:filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000217">
        <property type="term" value="P:regulation of invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000033">
        <property type="entry name" value="Nuclear protein SNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000049">
        <property type="entry name" value="Nuclear protein SNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="119"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="195"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="16">
        <location>
            <begin position="263"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0131404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG59209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="323" mass="36567" checksum="E75536BEBBEA547A" modified="2004-07-19" version="1">MRELTEEQRENIAIEQKLAVQSIRSFLQSKTSYDVLPVSYRLVVLDTALLVKKSLNVLLQNSIVSAPLWDSKTSRFAGLLTTTDFINVIQYYFSNPDKFDIVDKLQLDGLKEVEKAIGVDQLDTAYVHPSRPLYDACLKMLESRSGRIPLIDEDEETHREIVVSVLTQYRILKFVSLNCRETHLLQRPIGELGIISEQNMKFCHMSTPVIDVIQLLTQAGVSSVPITDENGVLINVYEAYDVLGLIKGGIYNDLSLSVGEALMRRSDDFEGVYTCTKNDKLSSIMDNIRKSRIHRFFVVDENGRLTGVLTLSDILRYILLGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU52</accession>
    <name>Q6FU52_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0F06325g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU52"/>
    <dbReference type="FunCoup" id="Q6FU52">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU52"/>
    <dbReference type="KEGG" id="cgr:2887731"/>
    <dbReference type="CGD" id="CAL0129248">
        <property type="gene designation" value="CAGL0F06325g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06325g"/>
    <dbReference type="eggNOG" id="ENOG502QT8Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010065_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU52"/>
    <dbReference type="OMA" id="VHGFEIY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="3">
        <location>
            <begin position="81"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="795"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0129248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="894" mass="103029" checksum="9FB9449D0A65CD8F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU69</accession>
    <name>CSN9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>COP9 signalosome complex subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CSN9</name>
        <name type="ordered locus">CAGL0F05841g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the COP9 signalosome (CSN) complex that acts as a regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response.</text>
    </comment>
    <comment type="subunit">
        <text>Component of a COP9 signalosome-like (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446225.1">
        <property type="nucleotide sequence ID" value="XM_446225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU69"/>
    <dbReference type="SMR" id="Q6FU69"/>
    <dbReference type="FunCoup" id="Q6FU69">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU69"/>
    <dbReference type="EnsemblFungi" id="CAGL0F05841g-T">
        <property type="protein sequence ID" value="CAGL0F05841g-T-p1"/>
        <property type="gene ID" value="CAGL0F05841g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887949"/>
    <dbReference type="KEGG" id="cgr:2887949"/>
    <dbReference type="CGD" id="CAL0129455">
        <property type="gene designation" value="CAGL0F05841g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05841g"/>
    <dbReference type="HOGENOM" id="CLU_138722_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU69"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016806">
        <property type="entry name" value="Csn9_fungi"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022632">
        <property type="entry name" value="UCP022632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0736">Signalosome</keyword>
    <feature type="chain" id="PRO_0000121018" description="COP9 signalosome complex subunit 9">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PCI">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <sequence length="146" mass="16635" checksum="637CDF40123C0F61" modified="2004-07-19" version="1">MDSYKTQWLTSEGDERVRCELLAFGTVEDLERGTLNAQDRNVLVKLSILNYVYGKQVVTFDALLKNYAQAGIELTDNDIEMILLELCNHGIMDVSIDSVAREVKVLQLSRYRDVYCGERELLVVNPTKVITNIEIIDTLQAYSDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUC7</accession>
    <name>Q6FUC7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Uridine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0F04499g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUC7"/>
    <dbReference type="FunCoup" id="Q6FUC7">
        <property type="interactions" value="630"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887940"/>
    <dbReference type="CGD" id="CAL0129568">
        <property type="gene designation" value="CAGL0F04499g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04499g"/>
    <dbReference type="eggNOG" id="KOG2466">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021555_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FUC7"/>
    <dbReference type="OMA" id="WGSFWPI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015213">
        <property type="term" value="F:uridine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF5">
        <property type="entry name" value="URIDINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="630" mass="71538" checksum="034FB0378E11FA10" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUD8</accession>
    <name>HEK2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Heterogeneous nuclear rnp K-like protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>KH domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">HEK2</name>
        <name type="synonym">KHD1</name>
        <name type="ordered locus">CAGL0F04257g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA-binding protein involved in the correct localization of transcripts in the cell. RNA localization is a widespread mechanism for achieving localized protein synthesis. Involved in structural and functional organization of telomeric chromatin and regulates silencing at the HMR locus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HEK2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446156.1">
        <property type="nucleotide sequence ID" value="XM_446156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUD8"/>
    <dbReference type="SMR" id="Q6FUD8"/>
    <dbReference type="FunCoup" id="Q6FUD8">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUD8"/>
    <dbReference type="EnsemblFungi" id="CAGL0F04257g-T">
        <property type="protein sequence ID" value="CAGL0F04257g-T-p1"/>
        <property type="gene ID" value="CAGL0F04257g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887647"/>
    <dbReference type="KEGG" id="cgr:2887647"/>
    <dbReference type="CGD" id="CAL0131408">
        <property type="gene designation" value="CAGL0F04257g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04257g"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022670_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FUD8"/>
    <dbReference type="OMA" id="TERSYFP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0779">Telomere</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000408188" description="Heterogeneous nuclear rnp K-like protein 2">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="KH 1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="KH 2" evidence="2">
        <location>
            <begin position="120"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="KH 3" evidence="2">
        <location>
            <begin position="244"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="349" mass="38915" checksum="F146EB5FE9C92BAF" modified="2004-07-19" version="1">MPVSHRILLSLKEAAKVIGTQGNSIQSVRDNNNNVKIGISEKVPGCSDRVLTCSGEVEDVCSALGDVVTLLNKPSENEEETDNHHFYFLNHLLPVPTLDDLKATDPEASEEALHEQLQNIGYLRLLVFNSQLSSIIGKGGNQIKSLIEKHGVKLVASRAFLPDSTERMLEIQGVPSAIKQVLLDICEIIAKEEEEEEKARAENNNGESTGRKRFERKYYPHLQRNNTNSSSNNGSVGNSANSQEYTATVMIPESYVGALAGKKGNRLANLRKFTKTKILMESRPNDLDNEHEDENDMEEDDGRLRKFTIIGSSSRSVNLAESMLQRNLATEIERRKERLRNLSENNESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUK2</accession>
    <name>Q6FUK2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 12">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0F02805g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 12"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUK2"/>
    <dbReference type="FunCoup" id="Q6FUK2">
        <property type="interactions" value="524"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUK2"/>
    <dbReference type="KEGG" id="cgr:2887597"/>
    <dbReference type="CGD" id="CAL0131202">
        <property type="gene designation" value="CAGL0F02805g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02805g"/>
    <dbReference type="eggNOG" id="KOG2628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065200_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FUK2"/>
    <dbReference type="OMA" id="GMVPQVW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000018">
        <property type="entry name" value="Protein-S-isoprenylcysteine O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0131202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="254" mass="28885" checksum="BD4DBC705FC8F95C" modified="2004-07-19" version="1">MTGSNKSEKFVPDAEGLPVIINGKAYPDIRRNPLDDIAVTSFALGILLGIFVGLLTFTQFRNFNVYIIALSIFHFLEFYVTAKVNPGKVNSDSFLLNNGIGYLGAHMFGVLECLVESIFFPNMKKISNSWVAIFLTIIGVILILLGQVSRSMAMYQAGKSFSHILKTEKLDDHTLVTTGIYGYLRHPSYFGFFWWAIGTQLLLLNPIALIVFVGVLWSFFNKRILIEEKYLIQFFGEQYINYKKRVKVWIPLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUL8</accession>
    <name>Q6FUL8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0F02453g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUL8"/>
    <dbReference type="FunCoup" id="Q6FUL8">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUL8"/>
    <dbReference type="KEGG" id="cgr:2887844"/>
    <dbReference type="CGD" id="CAL0131414">
        <property type="gene designation" value="CAGL0F02453g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02453g"/>
    <dbReference type="eggNOG" id="KOG4406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027718_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUL8"/>
    <dbReference type="OMA" id="KKISWVY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042805">
        <property type="term" value="F:actinin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080135">
        <property type="term" value="P:regulation of cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051510">
        <property type="term" value="P:regulation of unidimensional cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="187"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="614" mass="70319" checksum="83289984172B33F0" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUM0</accession>
    <name>Q6FUM0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PHO87</name>
        <name evidence="9 10" type="ordered locus">CAGL0F02387g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUM0"/>
    <dbReference type="FunCoup" id="Q6FUM0">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUM0"/>
    <dbReference type="KEGG" id="cgr:2887602"/>
    <dbReference type="CGD" id="CAL0131416">
        <property type="gene designation" value="PHO87"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02387g"/>
    <dbReference type="eggNOG" id="KOG1281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_8_0_1"/>
    <dbReference type="InParanoid" id="Q6FUM0"/>
    <dbReference type="OMA" id="DINNFPW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000185">
        <property type="term" value="P:regulation of phosphate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF110">
        <property type="entry name" value="INORGANIC PHOSPHATE TRANSPORTER PHO87-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="520"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="737"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="788"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="829"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="872"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="917"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0131416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="952" mass="105090" checksum="96EB40692DA330E4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-23" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUM3</accession>
    <name>LOC1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>60S ribosomal subunit assembly/export protein LOC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LOC1</name>
        <name type="ordered locus">CAGL0F02299g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for efficient assembly and nuclear export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 66S pre-ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LOC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446071.1">
        <property type="nucleotide sequence ID" value="XM_446071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUM3"/>
    <dbReference type="SMR" id="Q6FUM3"/>
    <dbReference type="FunCoup" id="Q6FUM3">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUM3"/>
    <dbReference type="EnsemblFungi" id="CAGL0F02299g-T">
        <property type="protein sequence ID" value="CAGL0F02299g-T-p1"/>
        <property type="gene ID" value="CAGL0F02299g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887670"/>
    <dbReference type="KEGG" id="cgr:2887670"/>
    <dbReference type="CGD" id="CAL0131356">
        <property type="gene designation" value="CAGL0F02299g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02299g"/>
    <dbReference type="eggNOG" id="ENOG502RY6R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096593_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FUM3"/>
    <dbReference type="OMA" id="RESMNTI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140693">
        <property type="term" value="F:molecular condensate scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140691">
        <property type="term" value="F:RNA folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033592">
        <property type="term" value="F:RNA strand annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037650">
        <property type="entry name" value="Loc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28028">
        <property type="entry name" value="60S RIBOSOMAL SUBUNIT ASSEMBLY/EXPORT PROTEIN LOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28028:SF1">
        <property type="entry name" value="60S RIBOSOMAL SUBUNIT ASSEMBLY_EXPORT PROTEIN LOC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0509">mRNA transport</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000308791" description="60S ribosomal subunit assembly/export protein LOC1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="129"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="203" mass="23668" checksum="0B333FEE4E2E3012" modified="2004-07-19" version="1">MGSIKKTKGKSQSTKRVVTPEVFADQQARNQLANAPNLTEKSERRKANKLQVKKEQARARLYGKKKKESTYSEKDLDLPSLNKAVNPGVKLRRGKKGKKFIDDHDSLTLHRLIKTIGDKYDDITESKLEKDRRLEVIRELKRQEIERKEAAKQSQLEEKKDELKKKSSIARSMRRKNRRDQERDLHTTSNDKVQRKKKSVSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUM4</accession>
    <name>Q6FUM4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0F02277g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the nucleoporin interacting component (NIC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446070.1">
        <property type="nucleotide sequence ID" value="XM_446070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUM4"/>
    <dbReference type="STRING" id="284593.Q6FUM4"/>
    <dbReference type="KEGG" id="cgr:2887782"/>
    <dbReference type="CGD" id="CAL0131076">
        <property type="gene designation" value="CAGL0F02277g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02277g"/>
    <dbReference type="eggNOG" id="KOG2168">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011846_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUM4"/>
    <dbReference type="OMA" id="RPHAVHM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007231">
        <property type="entry name" value="Nucleoporin_int_Nup93/Nic96"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11225">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP93 NUCLEOPORIN NUP93 DEAD EYE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04097">
        <property type="entry name" value="Nic96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG58994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="840" mass="95647" checksum="A627FD019566976F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUX5</accession>
    <name>MCR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>NADH-cytochrome b5 reductase 2</fullName>
            <ecNumber>1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Mitochondrial cytochrome b reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MCR1</name>
        <name type="ordered locus">CAGL0E06424g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445969.1">
        <property type="nucleotide sequence ID" value="XM_445969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUX5"/>
    <dbReference type="SMR" id="Q6FUX5"/>
    <dbReference type="FunCoup" id="Q6FUX5">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUX5"/>
    <dbReference type="EnsemblFungi" id="CAGL0E06424g-T">
        <property type="protein sequence ID" value="CAGL0E06424g-T-p1"/>
        <property type="gene ID" value="CAGL0E06424g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887376"/>
    <dbReference type="KEGG" id="cgr:2887376"/>
    <dbReference type="CGD" id="CAL0128682">
        <property type="gene designation" value="CAGL0E06424g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_E06424g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06424g"/>
    <dbReference type="eggNOG" id="KOG0534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_9_1_1"/>
    <dbReference type="InParanoid" id="Q6FUX5"/>
    <dbReference type="OMA" id="KGPEMQK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000330177" description="NADH-cytochrome b5 reductase 2">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="48"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="155"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="298" mass="33610" checksum="76B38A123EEB1C7A" modified="2004-07-19" version="1">MAFARFARPTQRFLPFAIGAVAVTAGALYLNGWNTIKNENPKVFIGDRKWIDLELEKIIEESHDTKRFFFKLPTDDSVSGLTLASAVLTKFMTPKGNPVIRPYTPVSDLSEKGYIEFVIKHYEGGKMTDHLFQLKPKDTLAFQGPIPKWQWKPNSFDTITLLGGGTGITPLYQLVHHITQNKEDKTKINLFYGSKTPSDILLKKELDDLQKKYPEQLNIQYFVDKDDTGKFDGNKGFITKDFLAKNAPGPKEKTQVFVCGPPPFMDSLSGQKKSPMEQGDLTGALKDLGYSQDQVFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUY4</accession>
    <name>Q6FUY4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0E06226g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58879.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUY4"/>
    <dbReference type="FunCoup" id="Q6FUY4">
        <property type="interactions" value="958"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUY4"/>
    <dbReference type="MEROPS" id="M01.006"/>
    <dbReference type="KEGG" id="cgr:2887347"/>
    <dbReference type="CGD" id="CAL0128708">
        <property type="gene designation" value="CAGL0E06226g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06226g"/>
    <dbReference type="eggNOG" id="KOG1046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003705_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FUY4"/>
    <dbReference type="OMA" id="MMEYVAI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030287">
        <property type="term" value="C:cell wall-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="82"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="297"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="586"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0128708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG58879.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="924" mass="104473" checksum="8996F6802B0EA9D8" modified="2008-09-23" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV33</accession>
    <name>Q6FV33_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Geranylgeranyl transferase type-1 subunit beta</fullName>
            <ecNumber evidence="4">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Geranylgeranyl transferase type I subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0E05126g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.59" evidence="4"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV33"/>
    <dbReference type="FunCoup" id="Q6FV33">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV33"/>
    <dbReference type="KEGG" id="cgr:2887299"/>
    <dbReference type="CGD" id="CAL0129144">
        <property type="gene designation" value="CAGL0E05126g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05126g"/>
    <dbReference type="eggNOG" id="KOG0367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028946_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FV33"/>
    <dbReference type="OMA" id="RWCLMRQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02895">
        <property type="entry name" value="GGTase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041960">
        <property type="entry name" value="GGTase_I_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="13">
        <location>
            <begin position="9"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0129144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="366" mass="41454" checksum="74D266AEA39424E0" modified="2004-07-19" version="1">MQNMPDQIKKKHVKYIERHLQLLPAKYEDNDVNKMAILYYSFQSLSLLGEDIQGKYSKYIPWIKSHLITKSAPKQNQRISGFVGSLNVRVDGVITFNLPNTLFALLVLALLKQHHYICHEMDGESIGRFVGLCQLPNGSFKSALDLSGTSVSPVDGEDLRFCYIAVALLYIIGCRSPADYSKYINVSKLLDYIKNQQCFDGAYGQYGEAHAGYTSCALSTLALLKARETIDENFVEKTLTWLSHRQVSSSDIMRKQEEQNPFYDTDDHGGFQGRPNKFADTCYATWCLNSIQLLTKEWQGYVDQRSLENYLLNVTQNQIIGGFSKNDADDPDLYHTCLGISALILLDERLDGSLFLPAHISKLFLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV52</accession>
    <name>OS9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein OS-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">YOS9</name>
        <name type="ordered locus">CAGL0E04686g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with missfolded ER lumenal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the OS-9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445892.1">
        <property type="nucleotide sequence ID" value="XM_445892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV52"/>
    <dbReference type="SMR" id="Q6FV52"/>
    <dbReference type="FunCoup" id="Q6FV52">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV52"/>
    <dbReference type="GlyCosmos" id="Q6FV52">
        <property type="glycosylation" value="7 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0E04686g-T">
        <property type="protein sequence ID" value="CAGL0E04686g-T-p1"/>
        <property type="gene ID" value="CAGL0E04686g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887510"/>
    <dbReference type="KEGG" id="cgr:2887510"/>
    <dbReference type="CGD" id="CAL0128972">
        <property type="gene designation" value="CAGL0E04686g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04686g"/>
    <dbReference type="eggNOG" id="KOG3394">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_395859_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FV52"/>
    <dbReference type="OMA" id="RETKICH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11745">
        <property type="entry name" value="Yos9_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041039">
        <property type="entry name" value="Yos9_DD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17880">
        <property type="entry name" value="Yos9_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0430">Lectin</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000043268" description="Protein OS-9 homolog">
        <location>
            <begin position="16"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="4">
        <location>
            <begin position="106"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="450"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>a mannooligosaccharide derivative</name>
            <dbReference type="ChEBI" id="CHEBI:71274"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>a mannooligosaccharide derivative</name>
            <dbReference type="ChEBI" id="CHEBI:71274"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>a mannooligosaccharide derivative</name>
            <dbReference type="ChEBI" id="CHEBI:71274"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>a mannooligosaccharide derivative</name>
            <dbReference type="ChEBI" id="CHEBI:71274"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>a mannooligosaccharide derivative</name>
            <dbReference type="ChEBI" id="CHEBI:71274"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>a mannooligosaccharide derivative</name>
            <dbReference type="ChEBI" id="CHEBI:71274"/>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="3">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q13438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3"/>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="696" mass="77860" checksum="0C2B391B255BC082" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV65</accession>
    <name>Q6FV65_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0E04400g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV65"/>
    <dbReference type="FunCoup" id="Q6FV65">
        <property type="interactions" value="936"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV65"/>
    <dbReference type="KEGG" id="cgr:2887483"/>
    <dbReference type="CGD" id="CAL0128870">
        <property type="gene designation" value="CAGL0E04400g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04400g"/>
    <dbReference type="eggNOG" id="KOG2509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_4_3_1"/>
    <dbReference type="InParanoid" id="Q6FV65"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070158">
        <property type="term" value="P:mitochondrial seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="207"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="289"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="305"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="376"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0128870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="451" mass="51147" checksum="EF454512AF50AAA8" modified="2004-07-19" version="1">MWAAVRHYSSKTLFLKPAKFDVKRIIRDIGLYKDSIARRELVGQEQLVGALDGQLAATYERTKDIHAKISAVQTERKALEFSIRQHKVHGDEVLKELRSLKSQFSALAEQLQEANSKIQDICLRLPNLIHESAPDTAPVIDRWINKGLYESFEQQENRDHVYIMTKCKQLLDLASASNISGNSWYYLINEGAQLETALVNYALDQAEKHGFQRCIPPSIARKEIIDACGFTPRDMNNEKQIYEIEDGNNKLGLTATAEITLAGMNANKILDLDENNPTKRLVGVSRSYRAEAGARGKDTKGLYRVHEFTKVELFCWSLPQHSEKVLEDLKEFQVKLISDLGLCAQVLNMPANDLGNPAYKKYDIEVWMPGRGKFGEVSSTSNCTDFQSRRLFTRYQNKESSKLEYVHTLNGTAMAVPRMILAIIENFYDPSTNMVTVPSPLIPYMNGKTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV78</accession>
    <name>Q6FV78_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein AFG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0E04114g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV78"/>
    <dbReference type="FunCoup" id="Q6FV78">
        <property type="interactions" value="833"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV78"/>
    <dbReference type="KEGG" id="cgr:2887312"/>
    <dbReference type="CGD" id="CAL0128904">
        <property type="gene designation" value="CAGL0E04114g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04114g"/>
    <dbReference type="eggNOG" id="KOG2383">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008681_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FV78"/>
    <dbReference type="OMA" id="ARRFINM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0128904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="57310" checksum="A2BC2B689EF521E5" modified="2004-07-19" version="1">MLVANVRALRCLRPQYNRITTLLYRFNHTEAVSIPLKEYKRLVKIGTLRDDEYQKGIISSLGHLYDSLVNYKPPEVKTPSALDQLSLMNSLKSKLGFFGKGSSQDVSKIPKGIYLYGDVGCGKTMLMDLFYSVLPPHLTKRRIHFHQFMQYVHKRSHEIIKEQNLDALGKAKGRDLDSIPFLAAEIAQTSHVLCFDEFQVADVADAMILRRLLTALLSPEYGVVLFATSNRPPDDLYINGVQRKSFIPCIELIKERTEVIFLDSPIDYRKIPRPISNVYCYPKHDEEYFSHEFEVIRKTHIQEWYSYFAQDSDSKNPDGTNLHGQQTFNDYKLSIWGRELNVPKCTPPKVAQFTFKELCGQPLAAGDYLTLASNFRSFIITDIPYLTIFVRDEIRRFITFLDAVYDNGGKIATTGAADFTSLFVEPDQLINDYKLKEQKKQDGFEEQAIENDELVEKHGFSKEIAQKSKIFALDEERFAFARALSRLSHMSSSDWVSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVD2</accession>
    <name>Q6FVD2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0E02827g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVD2"/>
    <dbReference type="FunCoup" id="Q6FVD2">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVD2"/>
    <dbReference type="KEGG" id="cgr:2887423"/>
    <dbReference type="CGD" id="CAL0128680">
        <property type="gene designation" value="CAGL0E02827g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02827g"/>
    <dbReference type="eggNOG" id="ENOG502RZ92">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055503_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVD2"/>
    <dbReference type="OMA" id="EYHDELC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035653">
        <property type="term" value="P:clathrin-coated vesicle cargo loading, AP-1-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0128680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="251" mass="29169" checksum="0FA9F3E859B8539E" modified="2004-07-19" version="1">MAENNSDSGDEFGDFEGVTDDQEQLVLYVNELVPKVNLGDVCQQKHDLEELLAEERPRVIYEQLVELHTVLQPITWKSSHLRSHLLHVMRLEEHDKSDKHIIEEAVDDQLYTRICSMLPTFSAEQVRSPALILRDQFKYMYAPPLTHSSLQGEAIHEQEEHVPSLLAVKMDSIQSAKEMEQYHDKLCNAIDALIVTLKQIELQQANLTADKTTYENVVTNLTGHTQRLQRDEIELYNKHKNRRKRFSWIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVJ7</accession>
    <name>Q6FVJ7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc-regulated transporter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0E01353g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445747.1">
        <property type="nucleotide sequence ID" value="XM_445747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVJ7"/>
    <dbReference type="FunCoup" id="Q6FVJ7">
        <property type="interactions" value="564"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVJ7"/>
    <dbReference type="KEGG" id="cgr:2887499"/>
    <dbReference type="CGD" id="CAL0128850">
        <property type="gene designation" value="CAGL0E01353g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01353g"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027089_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FVJ7"/>
    <dbReference type="OMA" id="ISEYPWV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0128850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="47920" checksum="6BEBA51F05B5ADF5" modified="2004-07-19" version="1">MDIVQLLFKRDDDDGPPPACAVDNDFNGHTNLRILSVFMVLISSAIGVYFPLLASRYSFINLPSWVFFIAKFFGSGVIVATAFIHLLEPASDSLGNPCLGGTFANYPWAFGICLMALFALFLIEIVSHHYVGKTMGGGHNHSHNMPTTFGQTHMHGVEDDMVDEDGSSSTHSHSHVAMDDKYGDVVKNNNYNYDDGSDDIESQKRPAFNVAQQKVRNDSNENDSLVGHVHNTTVDPLEHMPGHNHFSHDEVHQDITQIGSKANDQQKEQYLNQLTSLFILEFGILFHSVFVGLSLSVSGDEFKTLFVVIVFHQMFEGMGLGARITECYWPHSKRWLPYLLGFGYTITTPIAIAIGIGVRHSFVPGSRRSLIVNGVFDAISAGILVYAGLVELMAHEFLFTNQFKGEHGLRNMLAAYFVMALGAGLMALLGRWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVJ9</accession>
    <name>Q6FVJ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0E01309g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58664.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVJ9"/>
    <dbReference type="STRING" id="284593.Q6FVJ9"/>
    <dbReference type="KEGG" id="cgr:2887502"/>
    <dbReference type="CGD" id="CAL0128998">
        <property type="gene designation" value="CAGL0E01309g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01309g"/>
    <dbReference type="eggNOG" id="KOG2686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012712_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FVJ9"/>
    <dbReference type="OMA" id="EAPYYKI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58664.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="55263" checksum="F71E301A80E1803A" modified="2008-09-23" version="2">MITSPLQGSPTSPYCILLQLYNRNWRSSDLHVASDLNSDSLCLYKRLSMSYLKRKVYGSGKDKDLISLDSIPFTEKLLNPLTEENQFKQQVFEVIRELKLWDHECSDINKFKLRKIKGALTNIIYEAIYDDSSSLLLRVFGAKLEAIVARSYEIKVLQRLRESQLRGPVILGCFANGRFEAYVRGSASVARNDLADPWVMQNIAMRMNKLHTEVELTSDEQYLYGSCFQKLSDWFSILETVGEQWISDKKNLEKYLHVNDWQFFKDSVATYRDWCFANTHYSSQDNFVFCHNDLQHGNVLLIDKDNEKNKNLMLIDFEYAGPNPVAFDISNHMSEWMHDYDRLDSYKSDYDRYPSKDKIDEFIDCYLHHSHTPRTMLDKQKLKHDIELWRPCAQLFWSVWAILQSGTINTTTVNSRDATPEVNGKFNDEPEFQYLLFCKEKLSCFWGDLIQFNLVDKNDNRLIAESVNYLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVM0</accession>
    <name>Q6FVM0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0E00847g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58643.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FVM0">
        <property type="interactions" value="1148"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVM0"/>
    <dbReference type="KEGG" id="cgr:2887432"/>
    <dbReference type="CGD" id="CAL0129008">
        <property type="gene designation" value="CAGL0E00847g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00847g"/>
    <dbReference type="eggNOG" id="KOG0929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000691_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FVM0"/>
    <dbReference type="OMA" id="EVMCAYI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140455">
        <property type="term" value="P:cytoplasm protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SEC7" evidence="7">
        <location>
            <begin position="669"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="624"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1552"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1563"/>
            <end position="1578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58643.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1821" mass="205854" checksum="4AD62A5F7C0CD84E" modified="2008-09-23" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVW1</accession>
    <name>Q6FVW1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0D05148g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445633.1">
        <property type="nucleotide sequence ID" value="XM_445633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVW1"/>
    <dbReference type="STRING" id="284593.Q6FVW1"/>
    <dbReference type="KEGG" id="cgr:2886973"/>
    <dbReference type="CGD" id="CAL0127961">
        <property type="gene designation" value="CAGL0D05148g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05148g"/>
    <dbReference type="eggNOG" id="ENOG502SE22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156033_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FVW1"/>
    <dbReference type="OMA" id="QGFLWTG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="108" mass="12044" checksum="AB618324985BE8A3" modified="2004-07-19" version="1">MNGVIKIPDTRFEQTFRRAIDREVAKQNALSGKSTDDKKSGPSAYVICKVVVRDVLLMPFIQSVLWTGFLLGLKPWLRMVVGFGRRTGEYLNRALYGGRLPGGKTATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWE7</accession>
    <name>Q6FWE7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">IDP1</name>
        <name evidence="17 18" type="ordered locus">CAGL0D00770g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445447.1">
        <property type="nucleotide sequence ID" value="XM_445447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWE7"/>
    <dbReference type="FunCoup" id="Q6FWE7">
        <property type="interactions" value="873"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWE7"/>
    <dbReference type="GeneID" id="2887212"/>
    <dbReference type="KEGG" id="cgr:2887212"/>
    <dbReference type="CGD" id="CAL0128173">
        <property type="gene designation" value="IDP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00770g"/>
    <dbReference type="eggNOG" id="KOG1526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FWE7"/>
    <dbReference type="OMA" id="HGTVQRH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="21"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="87"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="106"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="322"/>
            <end position="327"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0128173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG58358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="423" mass="47376" checksum="D67E48943AFE8AC4" modified="2004-07-19" version="1">MLGRRCFASSAKLAKIKVKTPVVELDGDEMTRIIWDKIKKQLILPFLDVDLKYYDLSIQSRDKTKDQITHDSAEAIKKYGVGVKCATITPDEARVKEFNLTKMWKSPNGTIRNILGGTVFREPIVIPRVPRLVPGWEKPIIIGRHAHGDQYKATDAVIPGQGKLELVYKPNGDASKAEVMEVYDYKGPGVALAMYNTDESIRGFAHSSFKLALQKKLNLFLSTKNTILKKYDGRFKDIFQEVYDSEYKQKFAELNITYEHRLIDDMVAQMIKSKGGFIMALKNYDGDVQSDIVAQGFGSLGLMTSILITPDGKTFESEAAHGTVTRHYRKHQQGEETSTNSIASIFAWTRGLAKRGELDGTPDVVRFANILESATLNTVQQDGIMTKDLALACGKTDRASYVTTTEFLDAVEKRLQTEIKSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWJ8</accession>
    <name>Q6FWJ8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ARG1</name>
        <name evidence="14 15" type="ordered locus">CAGL0C05115g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445396.1">
        <property type="nucleotide sequence ID" value="XM_445396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWJ8"/>
    <dbReference type="FunCoup" id="Q6FWJ8">
        <property type="interactions" value="1023"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWJ8"/>
    <dbReference type="GeneID" id="2886799"/>
    <dbReference type="KEGG" id="cgr:2886799"/>
    <dbReference type="CGD" id="CAL0127578">
        <property type="gene designation" value="ARG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05115g"/>
    <dbReference type="eggNOG" id="KOG1706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FWJ8"/>
    <dbReference type="OMA" id="WRWTVSP"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="178"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0127578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="420" mass="46585" checksum="AC79D6106F2C3279" modified="2004-07-19" version="1">MSKGKVCLAYSGGLDTSIILAWLLEQGYEVVAFMADVGQEEDFEAARAKALKIGATKVVISDVREQFVKDIIFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAEQEGCFAVSHGCTGKGNDQIRFELSFYALKPDVQVIAPWRLPEFFNRFAGRKDLLDYAAEKGIPVAQTKAKPWSTDENMAHISYEAGILEDPNTTPPKDMWKLITDPMDAPNTPQDITLDFEKGIPVKLTYKDNATGKEHVVTDALELALHVSNLGRANGVGRIDIVENRYINLKSRGCYEQALLTILRKAHVDLEGLVLDKEVRQLRDQFVTTTYSKLLYNGSYFTPECEFIRAMIEPSQKTVNGTVRLSLYKGNVIVLGRYSNTESLYDATESSMDELTGFLPTDTTGFIAIQAIRVKKFGEAKKASGEKITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWJ9</accession>
    <name>Q6FWJ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0C05093g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445395.1">
        <property type="nucleotide sequence ID" value="XM_445395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWJ9"/>
    <dbReference type="FunCoup" id="Q6FWJ9">
        <property type="interactions" value="677"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWJ9"/>
    <dbReference type="MEROPS" id="M49.004"/>
    <dbReference type="KEGG" id="cgr:2886793"/>
    <dbReference type="CGD" id="CAL0127474">
        <property type="gene designation" value="CAGL0C05093g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05093g"/>
    <dbReference type="eggNOG" id="KOG3675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011977_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FWJ9"/>
    <dbReference type="OMA" id="QRYWIRD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0127474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG58301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="704" mass="79817" checksum="5857B8E07A5FAA13" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWR9</accession>
    <name>Q6FWR9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UBP3-associated protein BRE5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">BRE5</name>
        <name evidence="6 7" type="ordered locus">CAGL0C03421g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAG58231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445325.1">
        <property type="nucleotide sequence ID" value="XM_445325.1"/>
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    <dbReference type="AlphaFoldDB" id="Q6FWR9"/>
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        <property type="interactions" value="270"/>
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    <dbReference type="STRING" id="284593.Q6FWR9"/>
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    <dbReference type="KEGG" id="cgr:2886723"/>
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03421g"/>
    <dbReference type="eggNOG" id="KOG0116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036630_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWR9"/>
    <dbReference type="OMA" id="KTYYQRM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0016579">
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000156">
        <property type="term" value="P:regulation of retrograde vesicle-mediated transport, Golgi to ER"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000017">
        <property type="entry name" value="UBP3-associated protein BRE5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="396"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="288"/>
            <end position="312"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
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            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55280" checksum="8520CAA1E0E6E696" modified="2004-07-19" version="1">MGTPTIQEISYAFVRTYYERMNNNPSKMSNLYSNTAELTHIGYQQKVDENSDVLATVKLTGKENISKFFVRNEAKVNDLKVKLDSCDFQTTGVNHKSIFIVVTGELFWTGTPTYRFCQSFILTPTSPSSDSYDITNDIIRFLGDNFQSIKAARQNSGHKKEENKSVEKSKESQPAKEKKVEEKPKEEPKEQEKIAPVSPKAAKEAPAPAPAPTSASEPSVPKPVTPVLKKETTHPVTNNVTKEAQTQASPEKEEIDATKKESATTKETVKENNKAVKEVTEPKPVQENNSVSSRPSSSSTTPSQTPNQEQSSGPVKMTWASKLSQDTAVNTKAGFVKNEPIQTVKIEPSEEQEPSSSKKSSNGDRKFELAGRRENSSSTKTKKKPIFCTVNEDGFFPIYIRGTAGLKEDRLRNTLETNYGPVKKITMAENFSVVDFELQKSQTEAIETKKITIDGIEIYMERKTIKKSPTSTASSSSSSQGFTNVSKVYKKHAVKKKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2025-06-18" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWS8</accession>
    <name>SDHB_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber>1.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Iron-sulfur subunit of complex II</fullName>
            <shortName>Ip</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SDH2</name>
        <name type="ordered locus">CAGL0C03223g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="1">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445316.1">
        <property type="nucleotide sequence ID" value="XM_445316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWS8"/>
    <dbReference type="SMR" id="Q6FWS8"/>
    <dbReference type="FunCoup" id="Q6FWS8">
        <property type="interactions" value="774"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWS8"/>
    <dbReference type="EnsemblFungi" id="CAGL0C03223g-T">
        <property type="protein sequence ID" value="CAGL0C03223g-T-p1"/>
        <property type="gene ID" value="CAGL0C03223g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886893"/>
    <dbReference type="CGD" id="CAL0127242">
        <property type="gene designation" value="SDH2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_C03223g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03223g"/>
    <dbReference type="eggNOG" id="KOG3049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FWS8"/>
    <dbReference type="OMA" id="DGQYFGP"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0003">3Fe-4S</keyword>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="transit peptide" description="Mitochondrion">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000010348" description="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial">
        <location>
            <begin status="unknown"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="23"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with DHSD</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="253" mass="29054" checksum="2557E1940B402EA3" modified="2004-07-19" version="1" precursor="true">MFMLRVSRRGLATATSVPRLKTFKIYRWNPDKPTEKPHLQEYKVDLEDCGPMVLDALLKIKNEQDATLTFRRSCREGICGSCAMNIGGANTLACLCKIDQDESKTTKIYPLPHMFIVKDLVPDLTGFYQQYKSIQPYLQRTDYPADGKEVLQSIDDRKKLDGLYECILCACCSTSCPSYWWNQEEYLGPAVLMQAYRWLIDSRDQATKARRTMLQNSMSLYRCHTIMNCTRTCPKGLNPGRSIAEIKKQLAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWX0</accession>
    <name>Q6FWX0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">XPG-I domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0C02255g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWX0"/>
    <dbReference type="FunCoup" id="Q6FWX0">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWX0"/>
    <dbReference type="KEGG" id="cgr:2886856"/>
    <dbReference type="CGD" id="CAL0127318">
        <property type="gene designation" value="CAGL0C02255g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02255g"/>
    <dbReference type="eggNOG" id="KOG2520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016401_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWX0"/>
    <dbReference type="OMA" id="IMHYFHP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051908">
        <property type="term" value="F:double-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09906">
        <property type="entry name" value="H3TH_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09870">
        <property type="entry name" value="PIN_YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037316">
        <property type="entry name" value="Yen1_H3TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF72">
        <property type="entry name" value="HOLLIDAY JUNCTION RESOLVASE YEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="4">
        <location>
            <begin position="163"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="532"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0127318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="75673" checksum="7A291BFE209C13E1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXF3</accession>
    <name>Q6FXF3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0B02387g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXF3"/>
    <dbReference type="KEGG" id="cgr:2886708"/>
    <dbReference type="CGD" id="CAL0127882">
        <property type="gene designation" value="CAGL0B02387g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B02387g"/>
    <dbReference type="eggNOG" id="KOG2338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034867_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXF3"/>
    <dbReference type="OMA" id="EPHENEY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043633">
        <property type="term" value="P:polyadenylation-dependent RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF45">
        <property type="entry name" value="NOCTURNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="4">
        <location>
            <begin position="83"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0127882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG57974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="471" mass="54747" checksum="B0B9A9F9F099E856" modified="2004-07-19" version="1">MIERNGNTHNDMGYDKASGKYATPAEIEAKREARRLKKQKLREELLSRGLDPDFPAECQFIERPILLVPHGDNYERGLPLSIMTYNCLAQTLIRREMFPESGPALKWFVRSKVLLHEIKHYNADICCLQEIDDVQYDLFWSEELPKFGYKTIYFHQDSKSHGVMIAWKEELFQLESHMNIEFDKEAPAGIQPRTRTNNVGLLVALAFTDAFRARNNRIRTSRSGVIIGTFHLFWHPFGTYDRTRQCLVIKKKILEFAGTVKGDYCKMFTGDFNSQPNSVPYLVLTQPRAQLNTQQRTSIEASTAYRYSERRNLGKEYSMEEEEEEEEEEEKREYEYDQGTDPWNTPRPDEFDSTEEQRQLVNNLIDRCNDVPLCATSLYSIGYHTVDPTHIADHHEPELSSWSTKWAGLLDYIFYVNQRPSTPATFETANNIAIAGYLQMPTHAQMHNHSQPYTGEYPSDHISMMCALEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN29</accession>
    <name>B4UN29_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger Ogr/Delta-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0J06088g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAR58045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_002999572.1">
        <property type="nucleotide sequence ID" value="XM_002999526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN29"/>
    <dbReference type="FunCoup" id="B4UN29">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:9488023"/>
    <dbReference type="CGD" id="CAL0132880">
        <property type="gene designation" value="CAGL0J06088g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06088g"/>
    <dbReference type="HOGENOM" id="CLU_192397_1_0_1"/>
    <dbReference type="InParanoid" id="B4UN29"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR58045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7681" checksum="88246FF267829301" modified="2008-09-23" version="1">MDARVCPQCGELLHRFMIRMKHAVVMCANDKCMYPFNTPGGIESNLVYVEGSELLEASTKIEKPPSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN45</accession>
    <name>B4UN45_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0L04350g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAR58061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN45"/>
    <dbReference type="FunCoup" id="B4UN45">
        <property type="interactions" value="983"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UN45"/>
    <dbReference type="KEGG" id="cgr:9488039"/>
    <dbReference type="CGD" id="CAL0135634">
        <property type="gene designation" value="CAGL0L04350g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04350g"/>
    <dbReference type="eggNOG" id="KOG1774">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125186_1_0_1"/>
    <dbReference type="InParanoid" id="B4UN45"/>
    <dbReference type="OMA" id="VPPINCI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990935">
        <property type="term" value="F:splicing factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="14"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0135634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAR58061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="94" mass="10479" checksum="B1791122369650A4" modified="2008-09-23" version="1">MSGKSKGKAIVPPINCIFNHLQQQTPVTFWLYEQVGIRIRGTIRGFDEFMNVVIDDAVEVPIEAKSGRELVDQGTKLGRILLKGDNITLITPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-31" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>F2Z663</accession>
    <name>F2Z663_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein DSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0C04169g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F2Z663"/>
    <dbReference type="FunCoup" id="F2Z663">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="284593.F2Z663"/>
    <dbReference type="KEGG" id="cgr:2886837"/>
    <dbReference type="CGD" id="CAL0127470">
        <property type="gene designation" value="CAGL0C04169g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04169g"/>
    <dbReference type="eggNOG" id="ENOG502QW3C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_364101_0_0_1"/>
    <dbReference type="InParanoid" id="F2Z663"/>
    <dbReference type="OMA" id="CLSGTIW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF11">
        <property type="entry name" value="PROTEIN DSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="78247" checksum="E4C4410AC4D51988" modified="2011-05-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIM1</accession>
    <name>Q6FIM1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GND1</name>
        <name evidence="16 17" type="ordered locus">CAGL0M13343g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449923.1">
        <property type="nucleotide sequence ID" value="XM_449923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIM1"/>
    <dbReference type="FunCoup" id="Q6FIM1">
        <property type="interactions" value="1009"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIM1"/>
    <dbReference type="GeneID" id="2891214"/>
    <dbReference type="KEGG" id="cgr:2891214"/>
    <dbReference type="CGD" id="CAL0136761">
        <property type="gene designation" value="GND1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13343g"/>
    <dbReference type="eggNOG" id="KOG2653">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FIM1"/>
    <dbReference type="OMA" id="CVTHVGP"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
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        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="178"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
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        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
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        </ligand>
    </feature>
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        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG62903.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="489" mass="53513" checksum="14D49CAC80E76AFE" modified="2004-07-19" version="1">MSADFGLIGLAVMGQNLILNIADHGYTVVAYNRSVDKVHQFLDNEAKGKSIIGAESIEDLVAKLKRPRKIMMLVKAGAPVDGLIAQLVPHLEKGDIIIDGGNSHFPDSNRRYEELKAKGILFVGSGVSGGEDGARYGPSLMPGGAEEAWPHIKEIFQSISAKSDGEPCCDWVGPAGSGHYVKMVHNGIEYGDMQLICEAYDIMKRIGGFTDKEISEVFGKWDTGVLDSFLVEITTNILKKDDVDGKPLVEKIMDSAGQKGTGKWTAINALDLGMPVSLIGEAVFARCLSALKCERVKASKTLPGPEIPKDLIKDRQQFIDDLEQALYASKIISYAQGFMLIREAAKTYGWKLNNPAIALMWRGGCIIRSVFLGEITKAYRENPDLENLLFHKFFKDAVTKAQGGWRRSLALAATYGIPSPAFATALSFYDGYRSERLPANLLQAQRDYFGAHTFRVLPECASDSLPKDKDIHINWTGHGGNVSSTTYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIP8</accession>
    <name>Q6FIP8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial acidic protein MAM33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M12727g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIP8"/>
    <dbReference type="FunCoup" id="Q6FIP8">
        <property type="interactions" value="604"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIP8"/>
    <dbReference type="KEGG" id="cgr:2891447"/>
    <dbReference type="CGD" id="CAL0137397">
        <property type="gene designation" value="CAGL0M12727g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M12727g"/>
    <dbReference type="eggNOG" id="KOG2536">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072692_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FIP8"/>
    <dbReference type="OMA" id="CEYMMSK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902775">
        <property type="term" value="P:mitochondrial large ribosomal subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0137397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30855" checksum="ABC9F2E1F642C821" modified="2004-07-19" version="1">MFTRTAGLCLRRTALMLSRSGKANGSMVARTVLTKPMNHALIANSLLRAFHAGVTIHNQESKQVRDILNSELNLELESLKDEEAPPLDETFQEYLDKSGFSIVERPGKNEAELKKTTADGETVRVLFDVAQVSNLPYDASLAEAAANEQAINEDDYDALSDNFANVTVVVSKEGRSTLGFELLMNIQEGSFYVDSVTPYQGDNVALSESAEADAQRDAVYHGPPFSNLDEQLQESLEVFLESRGINEDLASFIGTYSEFKENNEYVDWLKKMKEFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIV9</accession>
    <name>Q6FIV9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">SWI/SNF complex subunit SWI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0M11374g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMARCC family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIV9"/>
    <dbReference type="FunCoup" id="Q6FIV9">
        <property type="interactions" value="1153"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIV9"/>
    <dbReference type="KEGG" id="cgr:2891404"/>
    <dbReference type="CGD" id="CAL0136303">
        <property type="gene designation" value="CAGL0M11374g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11374g"/>
    <dbReference type="eggNOG" id="KOG1279">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_302849_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIV9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048858">
        <property type="term" value="P:cell projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031496">
        <property type="term" value="P:positive regulation of mating type switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381:SF1">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15381">
        <property type="entry name" value="CHONDROITIN SULFATE PROTEOGLYCAN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="10">
        <location>
            <begin position="482"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="11">
        <location>
            <begin position="712"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="717"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="645"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="943"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="865"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="117"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="194"/>
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</entry>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
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                <person name="Jauniaux N."/>
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                <person name="Ma L."/>
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                <person name="Nicaud J.M."/>
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                <person name="Ozier-Kalogeropoulos O."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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</entry>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
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                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
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                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
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                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
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                <person name="Fabre E."/>
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                <person name="Nicaud J.M."/>
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                <person name="Ozier-Kalogeropoulos O."/>
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                <person name="Richard G.F."/>
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    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
        <property type="entry name" value="GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="7">
        <location>
            <begin position="47"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="149" mass="16335" checksum="FA4D36B0696B9A8C" modified="2004-07-19" version="1">MFATRLLGKSALLGTTSTRMVFRSQMARYMSTETKKAIEGAIASAPVVLFMKGTPEFPQCGFSRATISMLGQQGVDPEKFAAYNVLEDPELREGIKEFSNWPTIPQLYVNKEFIGGCDVITSMARSGELADVLEEANALVPEEKEEGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJH7</accession>
    <name>Q6FJH7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M06215g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJH7"/>
    <dbReference type="FunCoup" id="Q6FJH7">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJH7"/>
    <dbReference type="KEGG" id="cgr:2891665"/>
    <dbReference type="CGD" id="CAL0137239">
        <property type="gene designation" value="CAGL0M06215g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06215g"/>
    <dbReference type="eggNOG" id="KOG2949">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJH7"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0137239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="317" mass="34884" checksum="838E9913FEC4B60B" modified="2004-07-19" version="1">MMMLNRLKCLGKGPLRFYSVHSDTAGATKTILDLQRKYVERKPLTMCTAYDFITASWVQKADTDILLIGDSMGMTSLGYDSTSSLTLDEFKYHVKSVCRAEGPSFIVSDMPFGSFETSISQGIQTAIDLMRSSSKVKSMKIESGSCHSDHHTYKLIGELCSRGIPVMGHIGLTPQRQHSLGGFKVQANKSVQEIHDLLASAKKLEELGCWGIVLECIPQRVAGFITKALSIPTIGIGAGNQTSGQVLVVSDLLGFLDSTPPKFVKEYDNLGQRAIDSIKAYNSDVTTKAFPETGKHNFKIKEDIWNQFLSEVKVDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJU3</accession>
    <name>Q6FJU3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M03575g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJU3"/>
    <dbReference type="FunCoup" id="Q6FJU3">
        <property type="interactions" value="848"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJU3"/>
    <dbReference type="KEGG" id="cgr:2891511"/>
    <dbReference type="CGD" id="CAL0136885">
        <property type="gene designation" value="CAGL0M03575g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03575g"/>
    <dbReference type="eggNOG" id="KOG0990">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FJU3"/>
    <dbReference type="OMA" id="AEDNLPW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="331" mass="37301" checksum="F7426C570E998972" modified="2004-07-19" version="1">MMTEDRDNLPWVEKYRPQTLDDVYGQREVVGTVKKFVQEGKLPHLLFYGPPGTGKTSTIVALAKDIYGKNYSNMVLELNASDDRGIDVVRNQIKDFASTRQIFSKGFKLIILDEADAMTNAAQNALRRIIEKYTKNTRFCILANYSHKITPALLSRCTRFRFQPLPNDAVEKRMANVLVHEHLRISPAAKEALLELSNGDMRRVLNVLQASKATLESPEDEITDEVIYECCGAPRPQDIQTILKSILEDDWSTAYDTLTRIRSSNGLALIDLIESIVKILEEYKLKKEETRISLLSQLGDIEYAISKGGNDKIQSSAVIGAIKSSFELELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK12</accession>
    <name>Q6FK12_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SET6</name>
        <name evidence="2 3" type="ordered locus">CAGL0M02002g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449432.1">
        <property type="nucleotide sequence ID" value="XM_449432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK12"/>
    <dbReference type="FunCoup" id="Q6FK12">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK12"/>
    <dbReference type="GeneID" id="2891758"/>
    <dbReference type="KEGG" id="cgr:2891758"/>
    <dbReference type="CGD" id="CAL0136573">
        <property type="gene designation" value="SET6"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02002g"/>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038964_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FK12"/>
    <dbReference type="OMA" id="FRKEVCH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF294">
        <property type="entry name" value="POTENTIAL PROTEIN LYSINE METHYLTRANSFERASE SET6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="12"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="374" mass="43949" checksum="861B2A5C8EDF6F79" modified="2004-07-19" version="1">MTVTESYLQISEYFDINETSWGGRACFSKRDLNNGQVVLEVEDCMGTSIDYDFRKEVCHYCYKYNNGKSMKVKISFNDLQDCLYEFPQLATYKAKFKGAGLWFCCDTCRDKYLSIHNITELIESYEILLESFMRMIKNKSLLEEQEQDYNGITITKEYIDNTWEDITTRWIPMVRKTKATKRAKFLPQISEDEYNCCRFVSETLFRIKHLDPGSDTLEAFHNLQSNELSKIQKFPVLLNFQVLVFKTLFVLLPDNLKNSLTVQAFRHILGSEYGNAFGIWQDTEAVDSREYFGYWVFPKASYFNHSCDPNITKTRIDRKMVFTLNRDVACGEELNIDYSGVLDLPVDRRQKFLFENWFFVCGCNRCNSDLKLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKB8</accession>
    <name>Q6FKB8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ADP-ribosylation factor-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0L12826g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKB8"/>
    <dbReference type="FunCoup" id="Q6FKB8">
        <property type="interactions" value="766"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKB8"/>
    <dbReference type="KEGG" id="cgr:2890612"/>
    <dbReference type="CGD" id="CAL0136110">
        <property type="gene designation" value="CAGL0L12826g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12826g"/>
    <dbReference type="eggNOG" id="KOG0076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040729_7_2_1"/>
    <dbReference type="InParanoid" id="Q6FKB8"/>
    <dbReference type="OMA" id="HGFYKYM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04160">
        <property type="entry name" value="Arfrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001317">
        <property type="entry name" value="Putative ADP-ribosylation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0136110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="22970" checksum="59A88B8C8292D5C2" modified="2004-07-19" version="1">MFHLVKGLYNNWNKREQYSILILGLDNAGKTTFLETLKKEYSMHSKPLDKIAPTVGQNVATIPVDNNRSILKFWDVGGQASLRAMWSEYYPQCHGIIFVVDSTDRSRIDECSETLRTIVMDDEIEGIPILMLANKQDKPERMEVQDIKEIFNRIAEHMSARDSRVLPVCALTGEGIKDSIEWMILRLQRNKNDRPPVYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="154" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKG3</accession>
    <name>Q6FKG3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27 28" type="ordered locus">CAGL0L11814g</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FKG3">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKG3"/>
    <dbReference type="KEGG" id="cgr:2890945"/>
    <dbReference type="CGD" id="CAL0135792">
        <property type="gene designation" value="CAGL0L11814g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11814g"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000846_5_3_1"/>
    <dbReference type="InParanoid" id="Q6FKG3"/>
    <dbReference type="OMA" id="FIGTMEW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140345">
        <property type="term" value="F:phosphatidylcholine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090555">
        <property type="term" value="F:phosphatidylethanolamine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="308" mass="35400" checksum="F391AA778F981660" modified="2004-07-19" version="1">MITGNNYVEAPLEFRKQDIHETLQELLDDLKPIEFESYQDYFLINTFKKGISESGKVDIERLRSGGHTVYYQRVKRKRKSKGSSKEDEEISNPSRSSSKARSASDNNGSSSEEEDDYDSDYGNDNNRNKKKSGSNIDPNTNISESGSADSNFFNGNISKSSIIPAPVKGNVRRSSRLSLQQQQQLEKQKQIRKHQKQGSEEDLKKDETGDTNDFEEEKSDICDDSNSKEHIKDLFETLVEKVIEPKRRSDWVLPPRLRYQPEKQMRTKPAFDSVKINEVMANKSIRHILSRFEGGVAGVRKREWPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKR1</accession>
    <name>Q6FKR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol uptake protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SUT2</name>
        <name evidence="2 3" type="ordered locus">CAGL0L09383g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449183.1">
        <property type="nucleotide sequence ID" value="XM_449183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKR1"/>
    <dbReference type="FunCoup" id="Q6FKR1">
        <property type="interactions" value="876"/>
    </dbReference>
    <dbReference type="GeneID" id="2891129"/>
    <dbReference type="KEGG" id="cgr:2891129"/>
    <dbReference type="CGD" id="CAL0135730">
        <property type="gene designation" value="SUT2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09383g"/>
    <dbReference type="eggNOG" id="ENOG502S235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051216_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKR1"/>
    <dbReference type="OMA" id="EDYHEAG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="39869" checksum="4DF83B18532F0A28" modified="2004-07-19" version="1">MATSITVLNRDTSLPPLLLPNLSSSRASFGDSLSSVPSSRSNSSSTTLSRIDSTSSAASSVSSTDLFLSSQHVNLELKKARTDDHYYYNPAFAAATLSPVSSLPKPTQMLDVPTLSTLPSFTSTYTTHSPTTPGEVIGSANIGATLSKFESRAFKVSKSKKAILNLASPKQKLPSPKLGVIQKPISVPPKKSSPFVSAFNTMASNIKSTSDLVANNAGKRQRIGPSCDKCRSKKIKCDAKIDILCQDEAVLHMFGQSLHHELTKHEIETQLGQEVYSQSSTFAYISKDLMSKIESREPDAKIIKHLDKIIYFQPCTSCSRKKNTAVCAFSKGFTRADINIFSKIGSRVAQKPIYEMTYKEYKKAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKV6</accession>
    <name>Q6FKV6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L08316g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKV6"/>
    <dbReference type="FunCoup" id="Q6FKV6">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKV6"/>
    <dbReference type="KEGG" id="cgr:2890565"/>
    <dbReference type="CGD" id="CAL0135070">
        <property type="gene designation" value="CAGL0L08316g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08316g"/>
    <dbReference type="eggNOG" id="ENOG502QZWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1129615_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKV6"/>
    <dbReference type="OMA" id="CFINLIL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0135070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="253" mass="29671" checksum="7C371BCE86C8A8E5" modified="2004-07-19" version="1">MNYFIEKWIRVYLKCFINLILCHRNVYPKSSFTYTTYQGFNLPQYLPITRHHGLNSYIEEFISDLLGKLDHVYHLSLFVISKHNGWAIERYVLDFGQFQHGQPVDKDIVLKEGEVYDEFRSSLNSLITYLEKQTPIRDDTVTFEFVIDTIEMALGRKFGIDMDPKTSKSQVVDFERDTNWIRYHEDQNVPDGKEHSGAYKPKLKVTALIGCDWGPICIQQYNERLIVPNKGLSQVYYDDDQTNNFELTLGSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL29</accession>
    <name>Q6FL29_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L06644g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
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                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
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                <person name="Tekaia F."/>
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                <person name="Zeniou-Meyer M."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="gene designation" value="CAGL0L06644g"/>
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        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
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        <property type="entry name" value="RTT107_BRCT_6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
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        <location>
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            <end position="109"/>
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        <location>
            <begin position="117"/>
            <end position="216"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="CAG62035.1"/>
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        <source>
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    <sequence length="828" mass="92920" checksum="06F5C85103E6CF51" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLL7</accession>
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        <recommendedName>
            <fullName evidence="5">Transcriptional regulator MIT1</fullName>
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        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61847.1"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="68441" checksum="48AAAF92F6BEC181" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLY0</accession>
    <name>Q6FLY0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CBK1 kinase activator protein MOB2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0K12606g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
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                <person name="Nicaud J.M."/>
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                <person name="Ozier-Kalogeropoulos O."/>
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                <person name="Potier S."/>
                <person name="Richard G.F."/>
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                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
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                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Interacts with protein kinase CBK1 to form the RAM CBK1-MOB2 kinase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOB1/phocein family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG61727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="Q6FLY0">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLY0"/>
    <dbReference type="KEGG" id="cgr:2890419"/>
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        <property type="gene designation" value="CAGL0K12606g"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_038321_2_1_1"/>
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        <property type="component" value="Chromosome K"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007118">
        <property type="term" value="P:budding cell apical bud growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062200">
        <property type="term" value="P:RAM/MOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000100">
        <property type="term" value="P:regulation of establishment or maintenance of bipolar cell polarity regulating cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000004">
        <property type="entry name" value="CBK1 kinase activator protein MOB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0133923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG61727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="325" mass="36916" checksum="CD10F116B98F273C" modified="2004-07-19" version="1">MSFFNFKAFGRNSKKNKNGASNLGPSSNAGTPNTSTNASVLGSSHNQIMNSSNTQAQSIYSNQPSSSSKLSLRKNQSPTRTQSPSRLSHNNNNQILQERAQLSHSGTATNDTQSLSQRRSNSPERSSSQQVMFLSEPFVKTALVKGSFKTIVQLPKYVDLGEWIALNVFEFFTNLNHFYGVIAEYVTADAYPTMNAGPHTDYLWLDANNRQVSLPAGQYIDLALTWINNKVNDKSLFPTKNGVPFSPNFFKDVQRIMIQMFRIFGHIYHHHFDKIVHLSLEAHWNSFFAHFISFVKEFKIIDRREMYPLMPLIENFEKQGKIIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM45</accession>
    <name>Q6FM45_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Altered inheritance of mitochondria protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0K11110g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448699.1">
        <property type="nucleotide sequence ID" value="XM_448699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM45"/>
    <dbReference type="FunCoup" id="Q6FM45">
        <property type="interactions" value="135"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890087"/>
    <dbReference type="CGD" id="CAL0133915">
        <property type="gene designation" value="CAGL0K11110g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11110g"/>
    <dbReference type="eggNOG" id="ENOG502QSS3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017547_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM45"/>
    <dbReference type="OMA" id="HRRIFRV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="283"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="669"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="196"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="683"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="88398" checksum="FA0E7FD5CD9D430B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMB3</accession>
    <name>PNO1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PNO1</name>
        <name type="ordered locus">CAGL0K09460g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448631.1">
        <property type="nucleotide sequence ID" value="XM_448631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMB3"/>
    <dbReference type="SMR" id="Q6FMB3"/>
    <dbReference type="FunCoup" id="Q6FMB3">
        <property type="interactions" value="1013"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMB3"/>
    <dbReference type="EnsemblFungi" id="CAGL0K09460g-T">
        <property type="protein sequence ID" value="CAGL0K09460g-T-p1"/>
        <property type="gene ID" value="CAGL0K09460g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890233"/>
    <dbReference type="KEGG" id="cgr:2890233"/>
    <dbReference type="CGD" id="CAL0134609">
        <property type="gene designation" value="CAGL0K09460g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K09460g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09460g"/>
    <dbReference type="eggNOG" id="KOG3273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064992_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FMB3"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000278366" description="Pre-rRNA-processing protein PNO1">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="KH">
        <location>
            <begin position="182"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q99216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="261" mass="28866" checksum="18E1E7E6CF2E70BF" modified="2004-07-19" version="1">MVAPTAVKRQEEATAGPSRILGDGAPTAMIDEDDDEILIDQDMEEEAPKKSKKEAAGVVLDESGKPRFGAAKDQATTKVKLESRKVPVPPHRMTPLRNSWNKIYPPLVDHLKLQVRMNLKTRTVELRTHPKHTTDPGALQKGADFIKAFTLGFDLDDSIALLRLDDLYIETFEVKDVKTLTGDHLSRAIGRIAGKDGKTKFAIENATRTRIVLADSKIHILGGFTHIRMAREAVVSLILGSPPGKVYGNLRTVASRLKERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMC6</accession>
    <name>Q6FMC6_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0K09130g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMC6"/>
    <dbReference type="KEGG" id="cgr:2890249"/>
    <dbReference type="CGD" id="CAL0133863">
        <property type="gene designation" value="CAGL0K09130g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09130g"/>
    <dbReference type="HOGENOM" id="CLU_1026704_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMC6"/>
    <dbReference type="OMA" id="NEYTTTY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273452" evidence="2">
        <location>
            <begin position="23"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="271" mass="27310" checksum="698117C6B405C5E9" modified="2004-07-19" version="1">MQLKQYISALALAISTASAASAYSNSTYQASYQNAPLSSVNPTAAVSSVDANGNAAAAVPSSSSSSTFSATRGDTTTLQPPQSVVAQEVIITHSDETTTYYETSTLYSTVYLTNSKSKSVAAQDAAQQQKENVITVTKTDANGGVVTVVTTVTVGADSRPTGTVISDGSSGTTTSTITSTLFVTVRQSAVSVGPSNAPIGKELAGINSVSSSQSASAQGCVPVTTTVTDTVTDTVVSTVTATPSPSIQYVTVTMASNGTIASNGTINGTHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMJ4</accession>
    <name>Q6FMJ4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphomutase PMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PMU3</name>
        <name evidence="2 3" type="ordered locus">CAGL0K07568g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448550.1">
        <property type="nucleotide sequence ID" value="XM_448550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMJ4"/>
    <dbReference type="FunCoup" id="Q6FMJ4">
        <property type="interactions" value="207"/>
    </dbReference>
    <dbReference type="GeneID" id="2890382"/>
    <dbReference type="KEGG" id="cgr:2890382"/>
    <dbReference type="CGD" id="CAL0134887">
        <property type="gene designation" value="PMU3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07568g"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039184_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMJ4"/>
    <dbReference type="OMA" id="TCDHRRS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004787">
        <property type="term" value="F:thiamine diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000054">
        <property type="entry name" value="Putative phosphomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273354" description="Phosphomutase PMU1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="37429" checksum="6E68842F35B066F8" modified="2004-07-19" version="1">MILHKLLLLLNLDWNPDNTAQDLDFRALPGYFKGYTVQDTPDTKINATIFDFLALDDRFSNWQQMYQAIPNDTETHSYKLVILARHGQGYHNIGYDRYGEKAWYDYWARLDGDQYGNWFDSELTPLGKKQALEAGQTYLTNLTDGLQRLPDKFFVSPLRRCLDTCIREWEPIFAKHKPANSTVHVKVIEYLRETLGIDKSNERVDHSQALAEYQDHKYNTSDVTVHFDYPDDYAEKDQLWQPEHLETYPELDRRIKVGLREVFSSVNATDRVLSLTVHSDVIESILRNIKHPALVGLQTGKVIYTVVETTKKPADDQSILVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMJ7</accession>
    <name>Q6FMJ7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">CAGL0K07502g</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMJ7"/>
    <dbReference type="KEGG" id="cgr:2890379"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07502g"/>
    <dbReference type="HOGENOM" id="CLU_1294229_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMJ7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG61510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="213" mass="23933" checksum="73FF8119F5316471" modified="2004-07-19" version="1">MEVIHSVIAPALYSLLVSLPPLFVQSLPSTPQPHSLRHPFVAPLPSPSRFTANSWSFSPFLLFSFSFSFSPPCPCPSNYRLPRKNSPYKLEGSPPPLTLCLWSLYTVTVAPRTYYVNLDLSRLLALQSLRVLLIQRCGPPTNFTKHSVLHYTLHHIISTCIAISMSSRVLGYNTWLLFPFVLATSNKHVGSELQRMCLPSSLRNYRTMEGEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMQ9</accession>
    <name>Q6FMQ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein RED1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">RED1</name>
        <name evidence="2 3" type="ordered locus">CAGL0K06039g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMQ9"/>
    <dbReference type="FunCoup" id="Q6FMQ9">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMQ9"/>
    <dbReference type="KEGG" id="cgr:2890450"/>
    <dbReference type="CGD" id="CAL0134117">
        <property type="gene designation" value="RED1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06039g"/>
    <dbReference type="eggNOG" id="ENOG502QVW0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_334647_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMQ9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012491">
        <property type="entry name" value="Red1/Rec10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07964">
        <property type="entry name" value="Red1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001747">
        <property type="entry name" value="Rec10_Red1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="798" mass="92047" checksum="CD8861E62057A55A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMR4</accession>
    <name>Q6FMR4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">HAP1B</name>
        <name evidence="10" type="synonym">HAP1</name>
        <name evidence="10 11" type="ordered locus">CAGL0K05841g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448480.1">
        <property type="nucleotide sequence ID" value="XM_448480.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q6FMR4"/>
    <dbReference type="STRING" id="284593.Q6FMR4"/>
    <dbReference type="GeneID" id="2890473"/>
    <dbReference type="KEGG" id="cgr:2890473"/>
    <dbReference type="CGD" id="CAL0134327">
        <property type="gene designation" value="HAP1B"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05841g"/>
    <dbReference type="eggNOG" id="ENOG502QRPQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004380_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMR4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071456">
        <property type="term" value="P:cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000014">
        <property type="entry name" value="HAP1p Zinc finger transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
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        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="63"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="144"/>
            <end position="190"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="668"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1193"/>
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    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="114"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
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            <end position="154"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
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        <location>
            <begin position="1198"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0134327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1372" mass="152780" checksum="48209025875700BF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN49</accession>
    <name>HSE1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HSE1</name>
        <name type="ordered locus">CAGL0K02761g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448345.1">
        <property type="nucleotide sequence ID" value="XM_448345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN49"/>
    <dbReference type="SMR" id="Q6FN49"/>
    <dbReference type="FunCoup" id="Q6FN49">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN49"/>
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        <property type="protein sequence ID" value="CAGL0K02761g-T-p1"/>
        <property type="gene ID" value="CAGL0K02761g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890271"/>
    <dbReference type="KEGG" id="cgr:2890271"/>
    <dbReference type="CGD" id="CAL0134043">
        <property type="gene designation" value="CAGL0K02761g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02761g"/>
    <dbReference type="eggNOG" id="KOG2199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010104_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FN49"/>
    <dbReference type="OMA" id="QVYRDWW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of protein maturation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:protein secretion"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0006623">
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        <property type="project" value="EnsemblFungi"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3 Domains"/>
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        <property type="entry name" value="ENTH_VHS"/>
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        <property type="entry name" value="SH3-like_dom_sf"/>
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        <property type="entry name" value="SH3_domain"/>
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        <property type="entry name" value="STAM"/>
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        <property type="entry name" value="UIM_dom"/>
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        <property type="entry name" value="VHS_dom"/>
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    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
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        <property type="entry name" value="SH3_1"/>
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        <property type="entry name" value="VHS"/>
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        <property type="entry name" value="P67PHOX"/>
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        <property type="entry name" value="SH3DOMAIN"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
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        </location>
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    </feature>
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            <begin position="147"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="394"/>
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    <evidence type="ECO:0000250" key="1"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00213"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="450" mass="50644" checksum="53D1B2BD3B6CF62E" modified="2004-07-19" version="1">MPSLEVKLRKAVLAATDGKLRSDNWQYIIGVCDLVKEDPEDASQIVMEMIEKRLGQNDANVMLRSLALVVALAENCGSRLKQQVSSKHFTGILAQLLESGDVHMTVKKEIAKVVKQLSDSFKSDPSLKTMGDLNTRIRRKWPGLLEEPEKPSKQKVSHQEATDEDQELQRALKMSLEEFEKSKQQSNGSAVQSNSLQDHNQGQQQPQQQTTSGIRRVRALYDLNANEQDELSFRKGDVIVVLEQVYRDWWRGSLHGKIGIFPLNYVTPITEPSPVESQREQQIEEGVLSQAQNVQVLSAKMQMASGKGLSELNQDPEFNDLYSTVTPIRPHVTKLIGKYAKEKDDVIALRQVLLNAESTYNELLDRAAKSYSIPNTQAPPYAPAVTSQPGYVSNNTYQTTNGQYTQHNITPQQQYQVPSQNYQSQPPSMQSNHYIGYQHPGINDQPPPNY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2023-11-08" modified="2025-06-18" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN94</accession>
    <name>RPN4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type transcription factor RPN4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RPN4</name>
        <name type="ordered locus">CAGL0K01727g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2006" name="Mol. Microbiol." volume="61" first="704" last="722">
            <title>Pdr1 regulates multidrug resistance in Candida glabrata: gene disruption and genome-wide expression studies.</title>
            <authorList>
                <person name="Vermitsky J.P."/>
                <person name="Earhart K.D."/>
                <person name="Smith W.L."/>
                <person name="Homayouni R."/>
                <person name="Edlind T.D."/>
                <person name="Rogers P.D."/>
            </authorList>
            <dbReference type="PubMed" id="16803598"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2006.05235.x"/>
        </citation>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="BMC Genomics" volume="9" first="333" last="333">
            <title>Structure and properties of transcriptional networks driving selenite stress response in yeasts.</title>
            <authorList>
                <person name="Salin H."/>
                <person name="Fardeau V."/>
                <person name="Piccini E."/>
                <person name="Lelandais G."/>
                <person name="Tanty V."/>
                <person name="Lemoine S."/>
                <person name="Jacq C."/>
                <person name="Devaux F."/>
            </authorList>
            <dbReference type="PubMed" id="18627600"/>
            <dbReference type="DOI" id="10.1186/1471-2164-9-333"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2019" name="Mol. Biol. (Mosk.)" volume="53" first="274" last="281">
            <title>[Candida glabrata Rpn4-like Protein Complements the RPN4 Deletion in Saccharomyces cerevisiae].</title>
            <authorList>
                <person name="Karpov D.S."/>
                <person name="Grineva E.N."/>
                <person name="Kiseleva S.V."/>
                <person name="Chelarskaya E.S."/>
                <person name="Spasskaya D.S."/>
                <person name="Karpov V.L."/>
            </authorList>
            <dbReference type="PubMed" id="31099777"/>
            <dbReference type="DOI" id="10.1134/s002689841902006x"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2020" name="Antimicrob. Agents Chemother." volume="64" first="0" last="0">
            <title>Candida glabrata Transcription Factor Rpn4 Mediates Fluconazole Resistance through Regulation of Ergosterol Biosynthesis and Plasma Membrane Permeability.</title>
            <authorList>
                <person name="Pais P."/>
                <person name="California R."/>
                <person name="Galocha M."/>
                <person name="Viana R."/>
                <person name="Ola M."/>
                <person name="Cavalheiro M."/>
                <person name="Takahashi-Nakaguchi A."/>
                <person name="Chibana H."/>
                <person name="Butler G."/>
                <person name="Teixeira M.C."/>
            </authorList>
            <dbReference type="PubMed" id="32571817"/>
            <dbReference type="DOI" id="10.1128/aac.00554-20"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DNA-BINDING</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6">Transcription factor that acts as a transcriptional activator of a number of genes encoding proteasomal subunits (PubMed:31099777, PubMed:32571817). Plays a role in ergosterol and plasma membrane homeostasis, and subsequent azole resistance (PubMed:18627600, PubMed:32571817). Regulates the expression of 212 genes, activating 80 genes and repressing, likely in an indirect fashion, 132 genes (PubMed:32571817). Targets comprise several proteasome and ergosterol biosynthesis genes, including ERG1, ERG2, ERG3, and ERG11 (PubMed:32571817). Directly regulates ERG11 expression through the 3'-TTGCAAA-5' binding motif (PubMed:32571817).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
        <text evidence="6">The localization to the nucleus increases upon fluconazole stress.</text>
    </comment>
    <comment type="induction">
        <text evidence="3">Expression is up-regulated in a fluconazole-resistant mutant.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448300.1">
        <property type="nucleotide sequence ID" value="XM_448300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN94"/>
    <dbReference type="FunCoup" id="Q6FN94">
        <property type="interactions" value="4167"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN94"/>
    <dbReference type="EnsemblFungi" id="CAGL0K01727g-T">
        <property type="protein sequence ID" value="CAGL0K01727g-T-p1"/>
        <property type="gene ID" value="CAGL0K01727g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890026"/>
    <dbReference type="KEGG" id="cgr:2890026"/>
    <dbReference type="CGD" id="CAL0134161">
        <property type="gene designation" value="RPN4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01727g"/>
    <dbReference type="eggNOG" id="ENOG502RBAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038620_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN94"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001023">
        <property type="term" value="P:regulation of response to drug"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000459090" description="C2H2-type transcription factor RPN4">
        <location>
            <begin position="1"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C2H2-type" evidence="1">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="16803598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="18627600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="31099777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="32571817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="18627600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="499" mass="55914" checksum="CCD08C30E2CDF6C1" modified="2004-07-19" version="1">MTSIDLGLKRTLTDVLEDELYNMRLREQETAQEQLDLREAGKVRQVQLQQQQMFSQYADPSVTMMSGDVACEGVLSTAPANLLANPDIRQAPAPQAQAQMLQVNPEVLISYANKNSAHMNVSAVDDKLNRGLVDENSYYDDVDYSSMNAKMADWQLDDNVAMLDNNDARLIFDNEFADDDDLSDDENLFDEGLENYHNELVSSNSPIESLDVAEHKESVDDRLRKYHLDNIQNILSKTSTNDKDILQIKLPSDFTTTNLHSTNPSGLIEDPSQLVLGSSKKITEDTHVEEESKNLPDLTELTSATEIEDILLAVDSDDDDLYTKPIAKQTTKKDNSKPVEKTVVEKTSSVTKAGSNHSRSTLARPTAHARKLSSSRKQAPKVYNPKTTTKSTHTHSKNNATHEAFVCELVNSVTNEVCGAQFSRTYDLTRHQNTIHAKKRSIFRCSECIRALGDEGFQKTFSRLDALTRHIKAKHENLSLEERQQVTKYAKSNIGFVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNG2</accession>
    <name>Q6FNG2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EPA15</name>
        <name evidence="5 6" type="ordered locus">CAGL0J11968g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448232.1">
        <property type="nucleotide sequence ID" value="XM_448232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNG2"/>
    <dbReference type="GeneID" id="2889438"/>
    <dbReference type="KEGG" id="cgr:2889438"/>
    <dbReference type="CGD" id="CAL0133122">
        <property type="gene designation" value="EPA15"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11968g"/>
    <dbReference type="eggNOG" id="ENOG502S8JT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_308156_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNG2"/>
    <dbReference type="OMA" id="CCRREET"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273464" description="PA14 domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="940"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="4">
        <location>
            <begin position="87"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="698"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0133122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG61186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="958" mass="104613" checksum="ABB4EF666A891E15" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNN4</accession>
    <name>Q6FNN4_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J10318g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNN4"/>
    <dbReference type="FunCoup" id="Q6FNN4">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNN4"/>
    <dbReference type="KEGG" id="cgr:2889419"/>
    <dbReference type="CGD" id="CAL0129469">
        <property type="gene designation" value="CAGL0J10318g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10318g"/>
    <dbReference type="eggNOG" id="ENOG502SAJ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_715707_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNN4"/>
    <dbReference type="OMA" id="WERYANQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="386" mass="44163" checksum="63A909B75D21BAD7" modified="2004-07-19" version="1">MNTNEGHTTSVENDILNAVSNWEKYKQGQAGLPLTQATNAHRDYGSIKRKASIARHSSIQRKDFTNVQELKKYKDKKKFIFHRGFFKRNSKKNTNFTRIQDSNVKVKLEPHRFRNRAELESVMNYTDLRTLNLSQMYPRATDNAAAVYGIKRKYHYRPRVVPTVERIPSRVYHVDDSTVSRKNSIKRSMPSVRNSKVNQMRHRDPVVSITSQAPSGLSTSSTPTAIRRTIRRSKTSPGGYRNIRYRNLSREHQTIMKLWEQYMRNIIYQRIQLRITLMTTALTTDDSGSESGEVSAEDDAAHSILDEYVFSLPPAIEDDKSLSFRYTPTSGLSIDDPIVIPEEEMHEQLMAQPTALRSRLHVIHPGSSSITTTSSSHNHISTPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNS7</accession>
    <name>Q6FNS7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 5'-monophosphoramidase HNT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Histidine triad nucleotide-binding protein HNT1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0J09372g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP</text>
            <dbReference type="Rhea" id="RHEA:67916"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57890"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:67917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HINT family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNS7"/>
    <dbReference type="FunCoup" id="Q6FNS7">
        <property type="interactions" value="642"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNS7"/>
    <dbReference type="KEGG" id="cgr:2889929"/>
    <dbReference type="CGD" id="CAL0129523">
        <property type="gene designation" value="CAGL0J09372g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09372g"/>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FNS7"/>
    <dbReference type="OMA" id="YRVVMNC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043530">
        <property type="term" value="F:adenosine 5'-monophosphoramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000013">
        <property type="entry name" value="Hit family protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF1">
        <property type="entry name" value="ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="12">
        <location>
            <begin position="12"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="10 11">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="9">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0129523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG61068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="145" mass="16199" checksum="4478FB54863D2AE9" modified="2004-07-19" version="1">MSASVAHDAACIFCKIIKGEIPSFKLIETKHVYSFLDIQPTSQGHALVIPKWHGAKLHDIPDEYLHDVLPTAKKIAKALNLDADGNYNILQNNGRLAHQEVDHVHFHLIPKPDEKTGLIVGWPAKQADMDQLAKFHKELVAKLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNX2</accession>
    <name>Q6FNX2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0J08349g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNX2"/>
    <dbReference type="FunCoup" id="Q6FNX2">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNX2"/>
    <dbReference type="KEGG" id="cgr:2889704"/>
    <dbReference type="CGD" id="CAL0133204">
        <property type="gene designation" value="CAGL0J08349g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08349g"/>
    <dbReference type="eggNOG" id="ENOG502QPV9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006977_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FNX2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058155">
        <property type="entry name" value="Skg3/CAF120-like_PH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25381">
        <property type="entry name" value="PH_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="63"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="595"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1003" mass="110097" checksum="E6FDBA20297B2B3B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP19</accession>
    <name>SQS1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SQS1</name>
        <name type="ordered locus">CAGL0J07326g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SQS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448025.1">
        <property type="nucleotide sequence ID" value="XM_448025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP19"/>
    <dbReference type="FunCoup" id="Q6FP19">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP19"/>
    <dbReference type="EnsemblFungi" id="CAGL0J07326g-T">
        <property type="protein sequence ID" value="CAGL0J07326g-T-p1"/>
        <property type="gene ID" value="CAGL0J07326g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889588"/>
    <dbReference type="KEGG" id="cgr:2889588"/>
    <dbReference type="CGD" id="CAL0133348">
        <property type="gene designation" value="CAGL0J07326g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07326g"/>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021974_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FP19"/>
    <dbReference type="OMA" id="PVFMRID"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000324995" description="Protein SQS1">
        <location>
            <begin position="1"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="R3H">
        <location>
            <begin position="621"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="748"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="485"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="764"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="808" mass="92551" checksum="30A3BCBE9AACC555" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP58</accession>
    <name>Q6FP58_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 14">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="3 14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0J06424g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 14"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP58"/>
    <dbReference type="FunCoup" id="Q6FP58">
        <property type="interactions" value="1266"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP58"/>
    <dbReference type="KEGG" id="cgr:2889537"/>
    <dbReference type="CGD" id="CAL0132796">
        <property type="gene designation" value="CAGL0J06424g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06424g"/>
    <dbReference type="eggNOG" id="KOG0480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FP58"/>
    <dbReference type="OMA" id="RHQQTDK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033679">
        <property type="term" value="F:3'-5' DNA/RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006267">
        <property type="term" value="P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.870:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000009">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000115">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="508"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0132796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG60937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="972" mass="109309" checksum="3F9024CB4B74E94C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPA4</accession>
    <name>Q6FPA4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CP-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0J05412g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Westhof E."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
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                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
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                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
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                <person name="Lesur I."/>
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                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
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                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
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                <person name="Swennene D."/>
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                <person name="Scarpelli C."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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    </reference>
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    </evidence>
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            <dbReference type="EMBL" id="CAG60796.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="Swiss-Prot" created="2010-11-30" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName>Respiratory growth induced protein 1</fullName>
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        <name type="ordered locus">CAGL0J03080g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
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                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
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                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
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                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
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                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.</text>
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    <comment type="subcellular location">
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    <comment type="similarity">
        <text evidence="2">Belongs to the RGI1 family.</text>
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        <property type="protein sequence ID" value="CAG60787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="FunCoup" id="Q6FPK6">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPK6"/>
    <dbReference type="EnsemblFungi" id="CAGL0J03080g-T">
        <property type="protein sequence ID" value="CAGL0J03080g-T-p1"/>
        <property type="gene ID" value="CAGL0J03080g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889725"/>
    <dbReference type="KEGG" id="cgr:2889725"/>
    <dbReference type="CGD" id="CAL0129589">
        <property type="gene designation" value="CAGL0J03080g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J03080g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03080g"/>
    <dbReference type="eggNOG" id="ENOG502RZ9F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118207_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPK6"/>
    <dbReference type="OMA" id="HLKYYPP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006112">
        <property type="term" value="P:energy reserve metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Respiratory growth induced protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022554">
        <property type="entry name" value="RGI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038235">
        <property type="entry name" value="RGI1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10843">
        <property type="entry name" value="RGI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000402282" description="Respiratory growth induced protein 1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="157" mass="18893" checksum="97598EB58349A8B0" modified="2004-07-19" version="1">MAKKDKKPKVNTIVTKDGESLKVFEDLNDFEMFIKNETEDEEFDHIHCKLTYYPPFVLHESHDDPEKIKDTNNSHNKKFVRHLHQHVEKHLLKDIKEALHKPELKFHDKSKDETFEHIVWHYGEETEYHDRKFRIQVTVTCNHDDAMVDVDYKTIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPM2</accession>
    <name>Q6FPM2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0J02706g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPM2"/>
    <dbReference type="KEGG" id="cgr:2889752"/>
    <dbReference type="CGD" id="CAL0133388">
        <property type="gene designation" value="CAGL0J02706g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02706g"/>
    <dbReference type="HOGENOM" id="CLU_061029_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPM2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0133388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="379" mass="44657" checksum="2725DD433D46309D" modified="2004-07-19" version="1">MNLSEADWVICIALVKYKLRTISKQNRVYIPLLTDISSFNEDELQYCDLRRHLPSELSKNDKQEELINIFNLMWARRKNWENSLYCCDILLNNRTLLIHLLEDCTHQRLLLHYYGNYRFLLFYLNQQPCTRPTITTEAATISFRCYELIIISYFGLATNYHVTNKGIPNPIKRHLIDGLIFKFIKQELTALITNCPGYLNKSLIIRVQNNMLFLNVCVTSLQKSFIQTVSTIINTMITTRTTVFITNTNVEALMINLVTLLESFVSLLKCHNTKSKTAYARISSETRECKDKRIYAALYKKNFGKYNHSYKLFLKCVDKTVMFLLCLYKKLRFNKKTDQERMSQSTVAIMQQKRKQILAGLLAARKRELLIKYRKIRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPY6</accession>
    <name>Q6FPY6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MCM1</name>
        <name evidence="9 10" type="ordered locus">CAGL0I10769g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447708.1">
        <property type="nucleotide sequence ID" value="XM_447708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPY6"/>
    <dbReference type="FunCoup" id="Q6FPY6">
        <property type="interactions" value="361"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPY6"/>
    <dbReference type="GeneID" id="2889399"/>
    <dbReference type="KEGG" id="cgr:2889399"/>
    <dbReference type="CGD" id="CAL0132220">
        <property type="gene designation" value="MCM1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I10769g"/>
    <dbReference type="eggNOG" id="KOG0015">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063931_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FPY6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900079">
        <property type="term" value="P:regulation of arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900081">
        <property type="term" value="P:regulation of arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0056">Arginine metabolism</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0132220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="252" mass="28471" checksum="30624A6D3F15C461" modified="2004-07-19" version="1">MSDKEDINGNNMEDKVDDIDDDGSMTGSVSGSNSVLNEMSAEPKSNNGTSFENTSTPKDRRKIEIKFIENKTRRHVTFSKRKHGIMKKAFELSVLTGTQVLLLIVSETGLVYTFSTPKFEPIVTQQEGRNLIQACLNAPDEDGEEDDEEEQDEDHGDTQNGNPDLGSNSQTDLPHHLRQNAVHNQMLDNQQQLQNQNLLQQPQHSNQTLDHQALPQNHNPYPNIAMGDMGQQYMKGQDHQDPTYQQYFQDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ00</accession>
    <name>Q6FQ00_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2-21 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">E2 ubiquitin-conjugating enzyme PEX4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Peroxin-4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PEX4</name>
        <name evidence="16 17" type="ordered locus">CAGL0I10450g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="9">Protein modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447694.1">
        <property type="nucleotide sequence ID" value="XM_447694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ00"/>
    <dbReference type="FunCoup" id="Q6FQ00">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ00"/>
    <dbReference type="GeneID" id="2889243"/>
    <dbReference type="KEGG" id="cgr:2889243"/>
    <dbReference type="CGD" id="CAL0132360">
        <property type="gene designation" value="PEX4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I10450g"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030988_13_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ00"/>
    <dbReference type="OMA" id="WRAVMKG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000096">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-21 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="15">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0132360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG60639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="162" mass="18269" checksum="7F4A0D7EFA3B3A45" modified="2004-07-19" version="1">MARISKELLKIRKALEHGDSEFLVDLAPVDDSDLSRWFAVIKGPAETPYYPYEFKLAIEVPASYPMVPPTIKFVSDAKAGIRVPPHCNVDRRTGEICLDILKPEGWSPIWDILHVVQAIHILLQEPVPDSPLDVDMANILKNNDMSAYNGIIRYFLTEIDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ05</accession>
    <name>Q6FQ05_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PWP5</name>
        <name evidence="4 5" type="ordered locus">CAGL0I10340g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447689.1">
        <property type="nucleotide sequence ID" value="XM_447689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ05"/>
    <dbReference type="STRING" id="284593.Q6FQ05"/>
    <dbReference type="GeneID" id="2889212"/>
    <dbReference type="KEGG" id="cgr:2889212"/>
    <dbReference type="CGD" id="CAL0132062">
        <property type="gene designation" value="PWP5"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I10340g"/>
    <dbReference type="HOGENOM" id="CLU_297534_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ05"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049451">
        <property type="entry name" value="AWP2-like_YTTT_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20646">
        <property type="entry name" value="Hpf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273494" description="PA14 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="56"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="929"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0132062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1012" mass="108867" checksum="A4310315472D20F4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQD5</accession>
    <name>Q6FQD5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0I07117g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQD5"/>
    <dbReference type="FunCoup" id="Q6FQD5">
        <property type="interactions" value="302"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQD5"/>
    <dbReference type="KEGG" id="cgr:2889187"/>
    <dbReference type="CGD" id="CAL0132694">
        <property type="gene designation" value="CAGL0I07117g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07117g"/>
    <dbReference type="eggNOG" id="KOG3153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQD5"/>
    <dbReference type="OMA" id="TDMCKAL"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="229"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0132694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="314" mass="35779" checksum="E0FDB3779ECCD035" modified="2004-07-19" version="1">MAETCIENPDYLVVNGIPSSKYKHEIELENCFEPQHENSALLILNQEIKMPKLFMKLWNRYMIKVCADGAANKLYQFCVNNNVNHNDYLPDYIVGDLDSIDENIAQFYKEKGVYVIKQTTQYSTDFKKSINLITCHFYATNFKDHLQSSNEDSNYGISLEKGIHDIYATIKNVAELPKLNVLALGGIDGRFDQTIHSITQLYTLTNTDPYIRMFFLTENDLIFIIPPDGVLLRYDAEFRKACIGNCGLLPVGLPTEIIETIGLKWDVANWPTSIESGRVSSSNRFSGHDKCYINVKDGMIINVEIKKDVVANYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQN1</accession>
    <name>Q6FQN1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta type-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0I04906g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQN1"/>
    <dbReference type="FunCoup" id="Q6FQN1">
        <property type="interactions" value="1168"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQN1"/>
    <dbReference type="MEROPS" id="T01.P02"/>
    <dbReference type="KEGG" id="cgr:2889252"/>
    <dbReference type="CGD" id="CAL0132688">
        <property type="gene designation" value="CAGL0I04906g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04906g"/>
    <dbReference type="eggNOG" id="KOG0180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_10_0_1"/>
    <dbReference type="InParanoid" id="Q6FQN1"/>
    <dbReference type="OMA" id="CSEQLYG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0132688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22594" checksum="661709A8EF849831" modified="2004-07-19" version="1">MSDPSSINGGIVVAMAGKDCVAIACDLRLGNQSLGVSNNFEKVFNYGHVFFGITGLATDVTTLNELFRYKTNLYKLREDRPIEPETFTQLVSSTLYERRFGPYFVGPVVAGINSKSGKPFIAGFDLIGCIDEAKDFIVSGTASDQLFGMCESLYEPNLEAEDLFETISQALLNAADRDALSGWGAVVYIIKKDKVVKRYLKMRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQP9</accession>
    <name>Q6FQP9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine-rich transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0I04510g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYSTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447445.1">
        <property type="nucleotide sequence ID" value="XM_447445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQP9"/>
    <dbReference type="FunCoup" id="Q6FQP9">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQP9"/>
    <dbReference type="KEGG" id="cgr:2889029"/>
    <dbReference type="CGD" id="CAL0129797">
        <property type="gene designation" value="CAGL0I04510g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04510g"/>
    <dbReference type="eggNOG" id="ENOG502S7AZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162803_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQP9"/>
    <dbReference type="OMA" id="PQHKDDS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033101">
        <property type="term" value="C:cellular bud membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070250">
        <property type="term" value="C:mating projection membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028144">
        <property type="entry name" value="CYSTM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12734">
        <property type="entry name" value="CYSTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich transmembrane" evidence="5">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0129797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="116" mass="12936" checksum="745BC6EF23AE57CE" modified="2004-07-19" version="1">MSAQEYYNGAGDSKQQYSRPTAPPPSQGQGKDSSRGYYQAPPQAPQYQQQPPQGQYYQGGPPPQQQYYQQQGYPQQGQHGQQPIYVQQQPPQRGNDDCMTACLAALCICCTLDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQV9</accession>
    <name>Q6FQV9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I03102g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FQV9">
        <property type="interactions" value="1060"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQV9"/>
    <dbReference type="KEGG" id="cgr:2889165"/>
    <dbReference type="CGD" id="CAL0132708">
        <property type="gene designation" value="CAGL0I03102g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03102g"/>
    <dbReference type="eggNOG" id="KOG0928">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001204_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FQV9"/>
    <dbReference type="OMA" id="ILWTRSP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033363">
        <property type="term" value="P:secretory granule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000007">
        <property type="entry name" value="GDP/GTP exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="586"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1454" mass="165622" checksum="651ABB7CFE98CDF7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR25</accession>
    <name>Q6FR25_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Heat shock protein SSC1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0I01496g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR25"/>
    <dbReference type="STRING" id="284593.Q6FR25"/>
    <dbReference type="KEGG" id="cgr:2888959"/>
    <dbReference type="CGD" id="CAL0130430">
        <property type="gene designation" value="CAGL0I01496g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01496g"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FR25"/>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11734">
        <property type="entry name" value="ASKHA_NBD_HSP70_Ssc1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="600"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="553"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0130430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="69903" checksum="18A88FD197278CDD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR36</accession>
    <name>Q6FR36_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0I01232g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR36"/>
    <dbReference type="FunCoup" id="Q6FR36">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR36"/>
    <dbReference type="KEGG" id="cgr:2889116"/>
    <dbReference type="CGD" id="CAL0132498">
        <property type="gene designation" value="CAGL0I01232g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01232g"/>
    <dbReference type="eggNOG" id="KOG1690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066963_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FR36"/>
    <dbReference type="OMA" id="YYICISC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273510" description="GOLD domain-containing protein" evidence="11">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="12">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0132498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG60245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="210" mass="24085" checksum="13060BFB0BF53E09" modified="2004-07-19" version="1">MRLQYIIFLLGCLLQTSNALHTYVKSGEMKCFYKNLKKGDVLIGDLDTAVKNNGIYEEDPAVKVSVSIAETFDDDHIVLNQKNPYTGDFTFTALDNGEHRICVSPTYPDSNEPIRVYLDLEISNIEALDTKGKQNEAQLRKRVDQLNQRLNNIRMEQDVIRENEASFRNQSEAANSKITFWTLVQIFILAGMCTFQVSYLKNFFVKQKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR49</accession>
    <name>Q6FR49_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Casein kinase II subunit beta</fullName>
            <shortName evidence="3">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CKB2</name>
        <name evidence="4 5" type="ordered locus">CAGL0I00946g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447295.1">
        <property type="nucleotide sequence ID" value="XM_447295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR49"/>
    <dbReference type="FunCoup" id="Q6FR49">
        <property type="interactions" value="1139"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR49"/>
    <dbReference type="GeneID" id="2888914"/>
    <dbReference type="KEGG" id="cgr:2888914"/>
    <dbReference type="CGD" id="CAL0132726">
        <property type="gene designation" value="CKB2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00946g"/>
    <dbReference type="eggNOG" id="KOG3092">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034027_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FR49"/>
    <dbReference type="OMA" id="DADFGRC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030291">
        <property type="term" value="F:protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051873">
        <property type="term" value="P:killing by host of symbiont cells"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000002">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF39">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00045899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0132726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="259" mass="29984" checksum="17636F75EE0D4DFA" modified="2004-07-19" version="1">MTERDIQMADRMSTNTSRVELDDEVMDDATDSSEYAQMWIDLFLGRKGHEYFCDVDPEYITDRFNLINLQKTVSKFSQVVQYIVDELDDSIVENMSKARLEQLENDARKFYGLIHARYIITVKGLQKMLSKYKDADFGRCSRVYCNFQPLLPVGLHDVPGIDSVKLYCPSCEDLYNPKSSRHSSIDGAYFGTSFPGMFLQAFPDMVPKHPTARYVPKIFGFELHKQAQLTRWQELQRLKLVKRLQAKEVDLSKSGGFRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-06-28" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR71</accession>
    <name>HRI1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HRI1</name>
        <name type="ordered locus">CAGL0I00462g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447273.1">
        <property type="nucleotide sequence ID" value="XM_447273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR71"/>
    <dbReference type="SMR" id="Q6FR71"/>
    <dbReference type="FunCoup" id="Q6FR71">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR71"/>
    <dbReference type="EnsemblFungi" id="CAGL0I00462g-T">
        <property type="protein sequence ID" value="CAGL0I00462g-T-p1"/>
        <property type="gene ID" value="CAGL0I00462g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889317"/>
    <dbReference type="KEGG" id="cgr:2889317"/>
    <dbReference type="CGD" id="CAL0129598">
        <property type="gene designation" value="CAGL0I00462g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I00462g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00462g"/>
    <dbReference type="eggNOG" id="ENOG502QTYD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097607_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR71"/>
    <dbReference type="OMA" id="GEVNTTW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11692">
        <property type="entry name" value="HRI1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.310">
        <property type="entry name" value="Protein HRI1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038744">
        <property type="entry name" value="Hri1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000410809" description="Protein HRI1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="249" mass="27917" checksum="F8A70925C97DE9AC" modified="2004-07-19" version="1">MSAVLFKRLVFQVGDSANERTFTLSSVSKNGHFISLRPFTKPTEDEKKFPLEWVFAGTNDRVKVTPTTNADGKPVLQQDFDMGFDTNVYLNVENTHRGVINTFWQNWESGCVEETGKVFPFGNDKEGIPFMELWQPIDPNSKDLVILDAGDGRKIDGPVRSTVLKVVDGQDFEGLMIIVGEWAQGYLADKNKSSVDGLSFVRYHVSNEKLSSGLFEYGSQLSKFPTDFSNVKEGSLLTIDGLKWEVIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRF1</accession>
    <name>Q6FRF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FUR1</name>
        <name evidence="11 12" type="ordered locus">CAGL0H09064g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447193.1">
        <property type="nucleotide sequence ID" value="XM_447193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRF1"/>
    <dbReference type="FunCoup" id="Q6FRF1">
        <property type="interactions" value="777"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRF1"/>
    <dbReference type="GeneID" id="2888801"/>
    <dbReference type="KEGG" id="cgr:2888801"/>
    <dbReference type="CGD" id="CAL0131842">
        <property type="gene designation" value="FUR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09064g"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FRF1"/>
    <dbReference type="OMA" id="KHKIGLM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="13"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0131842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="216" mass="24493" checksum="B163BFE4DFAC0D53" modified="2004-07-19" version="1">MSSEPFKNVYLLPQTNQLLGLYTIIRDKNTTRPDFIFYSDRIIRLLVEEGLNHLPVENKDVDTHTSEVFNGVGFMGKICGVSIVRAGESMEQGLRDCCRSVRIGKILIQRDEETALPKLFYEKLPEDIADRYVFLLDPMLATGGSAMMATDVLIKRGVKPERIYFLNLICSKDGIDRYHAQFPDVKIVTGAIDKGLNEQKYLVPGLGDFGDRYYCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRH9</accession>
    <name>Q6FRH9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAGL0H08415g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRH9"/>
    <dbReference type="FunCoup" id="Q6FRH9">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRH9"/>
    <dbReference type="KEGG" id="cgr:2888886"/>
    <dbReference type="eggNOG" id="KOG2906">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FRH9"/>
    <dbReference type="OMA" id="MEFCDEC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="100" mass="11514" checksum="E130FD4AA5F33F73" modified="2004-07-19" version="1">MLLVATSDNGVYNLSCRSCPYEFPIESIEIYDRKKLPRKEVDDVLGGGWDNVDQTKVQCPNYDTCGGESAYFFQLQIRSADEPMTTFYKCVNCAHRWKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRL7</accession>
    <name>Q6FRL7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HXK2</name>
        <name evidence="15 16" type="ordered locus">CAGL0H07579g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447127.1">
        <property type="nucleotide sequence ID" value="XM_447127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRL7"/>
    <dbReference type="SMR" id="Q6FRL7"/>
    <dbReference type="FunCoup" id="Q6FRL7">
        <property type="interactions" value="583"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRL7"/>
    <dbReference type="GeneID" id="2888498"/>
    <dbReference type="KEGG" id="cgr:2888498"/>
    <dbReference type="CGD" id="CAL0130422">
        <property type="gene designation" value="HXK2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07579g"/>
    <dbReference type="eggNOG" id="KOG1369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014393_5_2_1"/>
    <dbReference type="InParanoid" id="Q6FRL7"/>
    <dbReference type="OMA" id="YHPNCRI"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990539">
        <property type="term" value="P:fructose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1250:FF:000001">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="227"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0130422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG60060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="486" mass="53663" checksum="3D4E93196F3AEECC" modified="2004-07-19" version="1">MVHLGPKKPPARKGSMVDMPKDLLDEIKKFEDMFSVDAATLQKVTKHFISELSKGLSKEGGNIPMIPAWVMENPTGKEKGDFLAIDLGGTNLRVVLVKLGGDRTFDTTQSKYKLPGPMRTTKDPEEIWSFIADSLETFIKEQFPEGCNETLPLGFTFSFPASQDKINQGVLQRWTKGFDIPNIEGHDVIPMLQKQIEKRNLPIDIVALINDTTGTLVASLYTDGETKMGVIFGTGVNGAYYDVVSDIPKLEGKLADDIPSSSLMAINCEYGSFDNEHVVLPRNKYDIAIDEESPRPGQQTFEKMSSGYYLGELLRLALLDLYNQGLIFKGQDVQKLKEAYIMDTSYPSRIEDDPFENLEDTDELFQADLGIQTTVQERKLIRRLCELIGTRSARLSVCGIAAICQKRGYETAHIAADGSVFNKYPGFQQRAAEGLRDIYGWKEDKPQNYPIVIVAAEDGSGAGAAIIAALAQKRIAEGKSLGVIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRM8</accession>
    <name>Q6FRM8_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H07337g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447116.1">
        <property type="nucleotide sequence ID" value="XM_447116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRM8"/>
    <dbReference type="KEGG" id="cgr:2888576"/>
    <dbReference type="CGD" id="CAL0131926">
        <property type="gene designation" value="CAGL0H07337g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07337g"/>
    <dbReference type="HOGENOM" id="CLU_1749392_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRM8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0131926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="149" mass="16971" checksum="1C90D6A719033171" modified="2004-07-19" version="1">MTRVDPVSAMRLAEEIAKRQEVLIYTRYQNNIEYYRELQRQADEMSVSDEVQSQISGVDDYLATTAKLYELSGNCKENKTHTNTNYDSNTQDKIARSPMPNVNCIDGGCAIDKPHSDSKSTFTPSTYVSCPFPLQDPRFKVIDVFLNEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRV5</accession>
    <name>Q6FRV5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alkaline ceramidase YDC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0H05599g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447039.1">
        <property type="nucleotide sequence ID" value="XM_447039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRV5"/>
    <dbReference type="FunCoup" id="Q6FRV5">
        <property type="interactions" value="569"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRV5"/>
    <dbReference type="KEGG" id="cgr:2888496"/>
    <dbReference type="CGD" id="CAL0129926">
        <property type="gene designation" value="CAGL0H05599g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05599g"/>
    <dbReference type="eggNOG" id="KOG2329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063293_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FRV5"/>
    <dbReference type="OMA" id="SIDWCEL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0129926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="36801" checksum="EDD54A490F00E0C8" modified="2004-07-19" version="1">MQFSWPYPDPETIDGYWGKPTALIDWCEENYVVTPYIAEWCNTITNAAFLVVAFYCTYSAYTNKLEKRFIFIGLGFSLVGIGSWLFHMTLQYRFQLLDELPMLYATVIPSWSIFVENQENLIKNVDERKAKSLRIQFIYSALLFGFVSILTWLYIVVRVVEIFQILYGVLTVMVVIASGILTYRDVHDPVAKRNLFTTMCLGIVPFVLGFICWQLDIHLCSLWIHIRRTYLELPLGILLELHGWWHLLTGTGVYIYVVYLQYLRVMTQGRGDDYIFIYRWSFFPELVKKGLTVRTPYSLEFWGPRADVKATKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRW9</accession>
    <name>Q6FRW9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl pyrophosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0H05269g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRW9"/>
    <dbReference type="FunCoup" id="Q6FRW9">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRW9"/>
    <dbReference type="KEGG" id="cgr:2888789"/>
    <dbReference type="CGD" id="CAL0131670">
        <property type="gene designation" value="CAGL0H05269g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05269g"/>
    <dbReference type="eggNOG" id="KOG0777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_6_0_1"/>
    <dbReference type="InParanoid" id="Q6FRW9"/>
    <dbReference type="OMA" id="ANFAYFW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033386">
        <property type="term" value="P:geranylgeranyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="38092" checksum="B4797BA3AD90FE01" modified="2004-07-19" version="1">MTLEKLKTLIESPPAWSQSDENSINQPYNHIASNPGKNFRAKLIHLFNQFYLLDENIIQTLTQIVEILHNSSLIIDDIEDNSQLRRGVVASHMLYGVPMSINTANYMYFVAMDLLRNLSHDAVTSNDLMKIFNEELLYLHRGQGLDIYWRDSLPKVVPTEEMYFNMVMNKTGGLFRLTLKIMERLSEYWQGQKSLVPLGNLLGIIYQVRDDYLNLTDSSMIETKGFADDISEGKLSFPIIHGINYAKIHDPNNTLLLDILCLKTKDENLKKNAIRYLSDCSKSFEYTSSVLKKLTTLLHSNSYFPDVTNDSTNSQTEAIKQVYNIMEKLANV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS09</accession>
    <name>Q6FS09_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">WAR1</name>
        <name evidence="3 4" type="ordered locus">CAGL0H04367g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446985.1">
        <property type="nucleotide sequence ID" value="XM_446985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS09"/>
    <dbReference type="FunCoup" id="Q6FS09">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS09"/>
    <dbReference type="GeneID" id="2888538"/>
    <dbReference type="KEGG" id="cgr:2888538"/>
    <dbReference type="CGD" id="CAL0131876">
        <property type="gene designation" value="WAR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04367g"/>
    <dbReference type="eggNOG" id="ENOG502QRSG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004837_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS09"/>
    <dbReference type="OMA" id="KPCIRCL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071468">
        <property type="term" value="P:cellular response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="61"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="835"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="945" mass="107608" checksum="DA8D6AA6B4C2F2E4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS12</accession>
    <name>Q6FS12_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0H04301g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS12"/>
    <dbReference type="FunCoup" id="Q6FS12">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS12"/>
    <dbReference type="KEGG" id="cgr:2888645"/>
    <dbReference type="CGD" id="CAL0129595">
        <property type="gene designation" value="CAGL0H04301g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04301g"/>
    <dbReference type="eggNOG" id="KOG0865">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FS12"/>
    <dbReference type="OMA" id="FNQDMQM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF327">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="24"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0129595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="183" mass="20196" checksum="DF6829BEC6C5F356" modified="2004-07-19" version="1">MLSRISMQKRFLSSTVAKLGKKVYFEPSVNGSRIGRIEFELYDDVVPKTAENFRALCTGEKGWGYKGVPFHRIIPQFMIQGGDTDLTNGFGGKSIYGNKFADENFTKTHDKPGLLSMANAGPNTNGSQFFITTVPCPWLDGKHVVFGEVTKGMDIVKTIESYGTMSGQPRAKIVVEESGEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS24</accession>
    <name>Q6FS24_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBM21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0H04037g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446970.1">
        <property type="nucleotide sequence ID" value="XM_446970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS24"/>
    <dbReference type="STRING" id="284593.Q6FS24"/>
    <dbReference type="CAZy" id="CBM21">
        <property type="family name" value="Carbohydrate-Binding Module Family 21"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888649"/>
    <dbReference type="CGD" id="CAL0131620">
        <property type="gene designation" value="CAGL0H04037g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04037g"/>
    <dbReference type="eggNOG" id="KOG3986">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014598_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS24"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF51">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT GAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM21" evidence="2">
        <location>
            <begin position="278"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="792"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="915" mass="102519" checksum="362CC63D061A5F7E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS64</accession>
    <name>Q6FS64_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0H03157g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS64"/>
    <dbReference type="FunCoup" id="Q6FS64">
        <property type="interactions" value="1182"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS64"/>
    <dbReference type="KEGG" id="cgr:2888679"/>
    <dbReference type="CGD" id="CAL0131464">
        <property type="gene designation" value="CAGL0H03157g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03157g"/>
    <dbReference type="eggNOG" id="KOG0896">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063065_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FS64"/>
    <dbReference type="OMA" id="GPESCSY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031371">
        <property type="term" value="C:ubiquitin conjugating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010994">
        <property type="term" value="P:free ubiquitin chain polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044395">
        <property type="term" value="P:protein targeting to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="139" mass="15732" checksum="8D51A1C07141C0CB" modified="2004-07-19" version="1">MSKVPRSFRLLEELEKGEKGLGPESCSYGLADADDITMTRWNGTILGPPHSNHENRIYSVSIECGPKYPDEPPTITFISKINLPCVDQSTGEVNKEKFNTLKDWKRLYNMETILLDLRKEMASPANKKLVQPEEGSTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS74</accession>
    <name>Q6FS74_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inactive deaminase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H02893g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446920.1">
        <property type="nucleotide sequence ID" value="XM_446920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS74"/>
    <dbReference type="FunCoup" id="Q6FS74">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS74"/>
    <dbReference type="KEGG" id="cgr:2888894"/>
    <dbReference type="CGD" id="CAL0131496">
        <property type="gene designation" value="CAGL0H02893g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02893g"/>
    <dbReference type="eggNOG" id="KOG1096">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003782_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FS74"/>
    <dbReference type="OMA" id="SYNIRWN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF7">
        <property type="entry name" value="INACTIVE DEAMINASE YBR284W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="101531" checksum="9588B8A79A02B168" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS75</accession>
    <name>NAGS_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Amino-acid acetyltransferase, mitochondrial</fullName>
            <ecNumber>2.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Arginine-requiring protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Glutamate N-acetyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>N-acetylglutamate synthase</fullName>
            <shortName>AGS</shortName>
            <shortName>NAGS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ARG2</name>
        <name type="ordered locus">CAGL0H02871g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">N-acetylglutamate synthase involved in arginine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.1"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446919.1">
        <property type="nucleotide sequence ID" value="XM_446919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS75"/>
    <dbReference type="FunCoup" id="Q6FS75">
        <property type="interactions" value="115"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS75"/>
    <dbReference type="EnsemblFungi" id="CAGL0H02871g-T">
        <property type="protein sequence ID" value="CAGL0H02871g-T-p1"/>
        <property type="gene ID" value="CAGL0H02871g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888569"/>
    <dbReference type="KEGG" id="cgr:2888569"/>
    <dbReference type="CGD" id="CAL0129457">
        <property type="gene designation" value="CAGL0H02871g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02871g"/>
    <dbReference type="eggNOG" id="KOG2436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013088_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS75"/>
    <dbReference type="OMA" id="HAWYELP"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106098">
        <property type="term" value="C:NAGS/NAGK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011190">
        <property type="entry name" value="GlcNAc_Synth_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF4">
        <property type="entry name" value="AMINO-ACID ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007892">
        <property type="entry name" value="NAGS_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000372558" description="Amino-acid acetyltransferase, mitochondrial">
        <location>
            <begin status="unknown"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="391"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="566" mass="64760" checksum="EE42D67B1E168BD1" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSC7</accession>
    <name>ZWINT_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Outer kinetochore KNL1 complex subunit KRE28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Spindle pole body component KRE28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">KRE28</name>
        <name type="ordered locus">CAGL0H01573g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a component of the outer kinetochore KNL1 complex that facilitates microtubule-kinetochore interactions and the spindle assembly checkpoint. Kinetochores, consisting of a centromere-associated inner segment and a microtubule-contacting outer segment, play a crucial role in chromosome segregation by mediating the physical connection between centromeric DNA and spindle microtubules. The outer kinetochore is made up of the ten-subunit KMN network, comprising the MIS12, NDC80 and KNL1 complexes, and auxiliary microtubule-associated components; together they connect the outer kinetochore with the inner kinetochore, bind microtubules, and mediate interactions with mitotic checkpoint proteins that delay anaphase until chromosomes are bioriented on the spindle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the KNL1/SPC105 complex composed of SPC105 and KRE28. Part of the ten-subunit outer kinetochore KMN network that includes the KNL1, MIS12 and NDC80 complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KRE28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446867.1">
        <property type="nucleotide sequence ID" value="XM_446867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSC7"/>
    <dbReference type="SMR" id="Q6FSC7"/>
    <dbReference type="FunCoup" id="Q6FSC7">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSC7"/>
    <dbReference type="EnsemblFungi" id="CAGL0H01573g-T">
        <property type="protein sequence ID" value="CAGL0H01573g-T-p1"/>
        <property type="gene ID" value="CAGL0H01573g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888670"/>
    <dbReference type="KEGG" id="cgr:2888670"/>
    <dbReference type="CGD" id="CAL0130607">
        <property type="gene designation" value="CAGL0H01573g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01573g"/>
    <dbReference type="eggNOG" id="ENOG502S19U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062083_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSC7"/>
    <dbReference type="OMA" id="GNEIDEC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180019">
        <property type="term" value="C:Knl1/Spc105 complex"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031619">
        <property type="term" value="P:homologous chromosome orientation in meiotic metaphase I"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905325">
        <property type="term" value="P:regulation of meiosis I spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031361">
        <property type="entry name" value="Kre28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17097">
        <property type="entry name" value="Kre28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000408561" description="Outer kinetochore KNL1 complex subunit KRE28">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q04431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="359" mass="42323" checksum="CE6007A077C660A5" modified="2004-07-19" version="1">MEAQLHELQEEITRSSDLVLTEQDKRLQGTLREIDQSIRKLIETSDYLKLSGDADSLIDIKQLEVKSRELDSLMDLLRKLYWREESLDLFLKYTINSDAEQVPVFSDTDPKYQSLQDEVSHLRDDVMTVKNQEIDQITGEILQVAHEITEKQDQVNMLYLETTNELDKCWELLDEWQRLQDDQRITKNEDNSNRKDTELNAMEECYEEWKTLEELAVLNDNLQKQIDELEKVDNKAINSTQLAEESIVNTVQLNDLIDMWKRRIIASIHEDISEIVLYPYSRKLQLRVANRYTIIIQLDKHQTHDGKSTIHDIDLFTEQDSRIIPMRELRKQVLQECKGHSNILQALKNIINRVINNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSE6</accession>
    <name>Q6FSE6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAGL0H01111g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSE6"/>
    <dbReference type="SMR" id="Q6FSE6"/>
    <dbReference type="STRING" id="284593.Q6FSE6"/>
    <dbReference type="KEGG" id="cgr:2888601"/>
    <dbReference type="eggNOG" id="ENOG502SC8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125054_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSE6"/>
    <dbReference type="OMA" id="DIYCYDV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052565">
        <property type="entry name" value="Glutaredoxin-like_YDR286C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33558:SF1">
        <property type="entry name" value="GLUTAREDOXIN-LIKE PROTEIN C5ORF63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="114" mass="13204" checksum="43F7E777AA90A9DD" modified="2004-07-19" version="1">MRSCLPRRLIQTATTGVSKGGVKLTLFSKPQCGLCEEAKEIIEDVLESDAIPKHNISMNIVNINQLNNKKWWDLYCFDIPVLHIEKDNDKESLFKMMHRIDEDVLVDKIQTYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSI2</accession>
    <name>Q6FSI2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein FMP27, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0H00330g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FSI2">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSI2"/>
    <dbReference type="KEGG" id="cgr:2888473"/>
    <dbReference type="CGD" id="CAL0131508">
        <property type="gene designation" value="CAGL0H00330g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00330g"/>
    <dbReference type="eggNOG" id="KOG1910">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000740_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSI2"/>
    <dbReference type="OMA" id="PNYFAKP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044233">
        <property type="term" value="C:mitochondria-associated endoplasmic reticulum membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF15">
        <property type="entry name" value="PROTEIN FMP27, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1178"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1299"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1718"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2474"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2482"/>
            <end position="2494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0131508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2635" mass="304478" checksum="C5147DDE7C903BB6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-20" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSP5</accession>
    <name>CSM2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Chromosome segregation in meiosis protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CSM2</name>
        <name type="ordered locus">CAGL0G08888g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chromosome segregation during meiosis. Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446749.1">
        <property type="nucleotide sequence ID" value="XM_446749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSP5"/>
    <dbReference type="SMR" id="Q6FSP5"/>
    <dbReference type="FunCoup" id="Q6FSP5">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSP5"/>
    <dbReference type="EnsemblFungi" id="CAGL0G08888g-T">
        <property type="protein sequence ID" value="CAGL0G08888g-T-p1"/>
        <property type="gene ID" value="CAGL0G08888g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888359"/>
    <dbReference type="KEGG" id="cgr:2888359"/>
    <dbReference type="CGD" id="CAL0130013">
        <property type="gene designation" value="CAGL0G08888g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_G08888g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08888g"/>
    <dbReference type="eggNOG" id="ENOG502S2QF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108124_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSP5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19478">
        <property type="entry name" value="Csm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031783">
        <property type="entry name" value="Csm2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16834">
        <property type="entry name" value="CSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0469">Meiosis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000280683" description="Chromosome segregation in meiosis protein 2">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="214" mass="24814" checksum="209FC512FAE11CCE" modified="2004-07-19" version="1">MPPKRYDDLSLLTLWPVAPDIDLAQYIYQFLTSEVGTQTEKEVYFTDSINSFPIHQLQELVNESNQSIYENIKINTALDLHELSSIIKKNTESLILKKIQNKKTNDLKPFQILSVINGLDVMFRSTLVSFTNEQAHLMLRDVMLRLRQVCNEYDCSPLTFKIILLFNRSDVMELLPKQRHSAAHQQKKMKYNNAMEGNSVGEFVGKYYCDEVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSR8</accession>
    <name>Q6FSR8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium permeable stress-gated cation channel 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0G08338g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="KEGG" id="cgr:2888205"/>
    <dbReference type="CGD" id="CAL0129399">
        <property type="gene designation" value="CAGL0G08338g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08338g"/>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002458_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FSR8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
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    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RSN1_TM"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="635"/>
            <end position="656"/>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="9">
        <location>
            <begin position="35"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="10">
        <location>
            <begin position="234"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="8">
        <location>
            <begin position="450"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0129399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="794" mass="91464" checksum="249346DA2E633E77" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT27</accession>
    <name>Q6FT27_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-directed RNA polymerases I, II, and III subunit RPABC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0G05874g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
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    <dbReference type="InParanoid" id="Q6FT27"/>
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        <property type="component" value="Chromosome G"/>
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    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:termination of RNA polymerase I transcription"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:termination of RNA polymerase III transcription"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0130801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG59544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7785" checksum="A80579CA2AC3E5B7" modified="2004-07-19" version="1">MSREGFQIPSNLDVAAAGTSHSKTATVKYICAECSSKLSLSRTDPVRCKDCGHRILLKARTRRMVQFEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT40</accession>
    <name>Q6FT40_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G05588g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2012" name="Mol. Cell. Biol." volume="32" first="186" last="198">
            <title>Analyses of Candida Cdc13 orthologues revealed a novel OB fold dimer arrangement, dimerization-assisted DNA binding, and substantial structural differences between Cdc13 and RPA70.</title>
            <authorList>
                <person name="Yu E.Y."/>
                <person name="Sun J."/>
                <person name="Lei M."/>
                <person name="Lue N.F."/>
            </authorList>
            <dbReference type="PubMed" id="22025677"/>
            <dbReference type="DOI" id="10.1128/mcb.05875-11"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 607-753</scope>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="PDB" id="3RMH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=607-753"/>
    </dbReference>
    <dbReference type="PDBsum" id="3RMH"/>
    <dbReference type="AlphaFoldDB" id="Q6FT40"/>
    <dbReference type="SMR" id="Q6FT40"/>
    <dbReference type="FunCoup" id="Q6FT40">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT40"/>
    <dbReference type="KEGG" id="cgr:2888025"/>
    <dbReference type="CGD" id="CAL0130659">
        <property type="gene designation" value="CAGL0G05588g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05588g"/>
    <dbReference type="eggNOG" id="ENOG502QU50">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011303_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT40"/>
    <dbReference type="EvolutionaryTrace" id="Q6FT40"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031749">
        <property type="entry name" value="Cdc13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040650">
        <property type="entry name" value="Cdc13_OB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041028">
        <property type="entry name" value="Cdc13_OB4_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16853">
        <property type="entry name" value="CDC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18691">
        <property type="entry name" value="Cdc13_OB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18233">
        <property type="entry name" value="Cdc13_OB4_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="2">
        <location>
            <begin position="417"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0130659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="3RMH"/>
        </source>
    </evidence>
    <sequence length="753" mass="87034" checksum="9243858774FA20C6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT64</accession>
    <name>Q6FT64_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0G05049g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT64"/>
    <dbReference type="FunCoup" id="Q6FT64">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT64"/>
    <dbReference type="KEGG" id="cgr:2887989"/>
    <dbReference type="CGD" id="CAL0130366">
        <property type="gene designation" value="CAGL0G05049g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05049g"/>
    <dbReference type="eggNOG" id="KOG1736">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087056_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT64"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="4">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0130366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="149" mass="16962" checksum="C465F22464B3F02F" modified="2004-07-19" version="1">MSNLYQIDSETKERIRKFRISTSRADTIKALPLKIEPKPSYKIVIEEDELEELDEADGLADYGEALPDNSPRYVLIAYPLTNKDGIKQTPLILIYWIPQTVVSQEWKMLYAGALELIRNECGTSKLVEVTSGLEDDSDVEELIAQIETR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-02-28" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTB1</accession>
    <name>TPO11_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Multidrug transporter TPO1_1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Clotrimazole exporter TPO1_1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Drug:H(+) antiporter TPO1_1</fullName>
            <shortName evidence="8">DHA TPO1_1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TPO1_1</name>
        <name type="ordered locus">CAGL0G03927g</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2016" name="Mol. Cell. Proteomics" volume="15" first="57" last="72">
            <title>Membrane proteome-wide response to the antifungal drug clotrimazole in Candida glabrata: role of the transcription factor CgPdr1 and the drug:H+ antiporters CgTpo1_1 and CgTpo1_2.</title>
            <authorList>
                <person name="Pais P."/>
                <person name="Costa C."/>
                <person name="Pires C."/>
                <person name="Shimizu K."/>
                <person name="Chibana H."/>
                <person name="Teixeira M.C."/>
            </authorList>
            <dbReference type="PubMed" id="26512119"/>
            <dbReference type="DOI" id="10.1074/mcp.M114.045344"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INDUCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="526" last="526">
            <title>Clotrimazole drug resistance in Candida glabrata clinical isolates correlates with increased expression of the drug:H(+) antiporters CgAqr1, CgTpo1_1, CgTpo3, and CgQdr2.</title>
            <authorList>
                <person name="Costa C."/>
                <person name="Ribeiro J."/>
                <person name="Miranda I.M."/>
                <person name="Silva-Dias A."/>
                <person name="Cavalheiro M."/>
                <person name="Costa-de-Oliveira S."/>
                <person name="Rodrigues A.G."/>
                <person name="Teixeira M.C."/>
            </authorList>
            <dbReference type="PubMed" id="27148215"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.00526"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2017" name="Cell. Microbiol." volume="19" first="0" last="0">
            <title>The multidrug resistance transporters CgTpo1_1 and CgTpo1_2 play a role in virulence and biofilm formation in the human pathogen Candida glabrata.</title>
            <authorList>
                <person name="Santos R."/>
                <person name="Costa C."/>
                <person name="Mil-Homens D."/>
                <person name="Romao D."/>
                <person name="de Carvalho C.C."/>
                <person name="Pais P."/>
                <person name="Mira N.P."/>
                <person name="Fialho A.M."/>
                <person name="Teixeira M.C."/>
            </authorList>
            <dbReference type="PubMed" id="27780306"/>
            <dbReference type="DOI" id="10.1111/cmi.12686"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4 5 6">Multidrug resistance transporter involved in resistance to azole antifungal drugs such as the imidazoles miconazole, ketoconazole, and tioconazole; as well as the triazoles itraconazole and fluconazole (PubMed:26512119). Also plays a role in the resistance to other antifungal drug families such as the polyene amphotericin B, the pyrimide analog flucytosine, the fungicide mancozeb, and the polyamine spermine (PubMed:26512119). Decreases the intracellular accumulation of clotrimazole by mediating its extrusion from cells (PubMed:26512119, PubMed:27148215). Involved in virulence by conferring resistance to the human antimicrobial peptide histatin-5 (PubMed:27780306).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="4">Expression is up-regulated by clotrimazole (PubMed:26512119).</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 6">Leads to intracellular accumulation of clotrimazole and increases the susceptibility to clotrimazole but also to other imidazoles such as miconazole, ketoconazole, and tioconazole; as well as triazoles such as itraconazole and fluconazole (PubMed:26512119). Also increases susceptibility to other antifungal drug families such as the polyene amphotericin B, the pyrimide analog flucytosine, the fungicide mancozeb, and the polyamine spermine (PubMed:26512119). Decreases virulence in a Galleria mellonella model of infection (PubMed:27780306).</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTB1"/>
    <dbReference type="FunCoup" id="Q6FTB1">
        <property type="interactions" value="118"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTB1"/>
    <dbReference type="GlyCosmos" id="Q6FTB1">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0G03927g-T">
        <property type="protein sequence ID" value="CAGL0G03927g-T-p1"/>
        <property type="gene ID" value="CAGL0G03927g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888403"/>
    <dbReference type="CGD" id="CAL0137711">
        <property type="gene designation" value="TPO1_1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_G03927g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03927g"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_4_1"/>
    <dbReference type="InParanoid" id="Q6FTB1"/>
    <dbReference type="PHI-base" id="PHI:6625"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033101">
        <property type="term" value="C:cellular bud membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015847">
        <property type="term" value="P:putrescine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF31">
        <property type="entry name" value="POLYAMINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="chain" id="PRO_0000443414" description="Multidrug transporter TPO1_1">
        <location>
            <begin position="1"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="26512119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="27148215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="6">
        <source>
            <dbReference type="PubMed" id="27780306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="7">
        <source>
            <dbReference type="PubMed" id="26512119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="8">
        <source>
            <dbReference type="PubMed" id="27148215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="9"/>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="567" mass="62560" checksum="D2B173C5C7B0F47F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTB5</accession>
    <name>Q6FTB5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Heat shock protein SSA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SSA1</name>
        <name evidence="8 9" type="ordered locus">CAGL0G03795g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FTB5">
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    <dbReference type="STRING" id="284593.Q6FTB5"/>
    <dbReference type="KEGG" id="cgr:2888331"/>
    <dbReference type="CGD" id="CAL0130109">
        <property type="gene designation" value="SSA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03795g"/>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_7_0_1"/>
    <dbReference type="InParanoid" id="Q6FTB5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000016">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="607"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="509"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0130109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="640" mass="69512" checksum="82C43EB25189FFE5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTC9</accession>
    <name>Q6FTC9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0G03487g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTC9"/>
    <dbReference type="FunCoup" id="Q6FTC9">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888183"/>
    <dbReference type="CGD" id="CAL0130282">
        <property type="gene designation" value="CAGL0G03487g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03487g"/>
    <dbReference type="eggNOG" id="KOG1278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010714_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FTC9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0130282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="704" mass="80689" checksum="A60BD836D214519F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTQ9</accession>
    <name>Q6FTQ9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G00462g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446385.1">
        <property type="nucleotide sequence ID" value="XM_446385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTQ9"/>
    <dbReference type="KEGG" id="cgr:2888265"/>
    <dbReference type="CGD" id="CAL0137705">
        <property type="gene designation" value="CAGL0G00462g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G00462g"/>
    <dbReference type="HOGENOM" id="CLU_1495997_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTQ9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018809">
        <property type="entry name" value="DUF2406"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28186:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10295">
        <property type="entry name" value="DUF2406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="180" mass="20880" checksum="CE32CB79D2DE0856" modified="2004-07-19" version="1">MSKEATIYKGNQTQKDQSKRDKKGKKKLRLKVNDSVLGAVQEAQPFEEAADQFKKPGAYYGITKNEVINDVFGCQIQDPDRSNPTRKTDERPLDTIRGFQYSITGDSRILTQLETPIYGFQMRPDFNFNDIATAQKYNQEVHSSEIRKPEIIEYISDEESLESPSKWSWLFLKKPERIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTY8</accession>
    <name>Q6FTY8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0F07777g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTY8"/>
    <dbReference type="FunCoup" id="Q6FTY8">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTY8"/>
    <dbReference type="KEGG" id="cgr:2887829"/>
    <dbReference type="CGD" id="CAL0131152">
        <property type="gene designation" value="CAGL0F07777g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07777g"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FTY8"/>
    <dbReference type="OMA" id="VRHVMIK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0131152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG59230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="504" mass="55973" checksum="464B8276A7A42D11" modified="2004-07-19" version="1">MPEVFEEINIPQIGRSYKQPIGIFIDNEFVPSSNGEKIETINPATEEVITSFYAATEDDVDKAVKSARESYENVWFKISPAEKRDMLLKLADLIEEEKPLLAALETLDAGKPYHTNAMDDIDQIIHLTKYFAGATDKFTQGKTIPIDHEKLVYTLKSPYGVCGMIIPWNYPLAMASWKMQGCLAAGNTLVIKPAENTSLSLLYLAQLFKKAGFPKGVVNVVPGKGSVVGNSLGLHMDVDKISFTGSTKVGSSILELAGKSNMKDVTLECGGKSPAVVFQDADIDNAIEYIANGIFYNSGQNCTANSRVYVQEDIYDDFIKRFTEHTKENWKFGSKCDPFDKDCTVGPVVSEKQFETVNDYIRHGKEEENLQIHQTVEKCDCKGYFISPTIFTDVPQGSKLMKEEIFGPVVVVAKFKDYKEAIKLANDTNYGLASMVFTKNISVANWFARDIKSGTVWINSSNEEDPTVPFGGFKQSGIGRELGETGVESYMQIKTVHLNMSEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU18</accession>
    <name>Q6FU18_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0F07073g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU18"/>
    <dbReference type="FunCoup" id="Q6FU18">
        <property type="interactions" value="945"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU18"/>
    <dbReference type="KEGG" id="cgr:2887640"/>
    <dbReference type="CGD" id="CAL0130872">
        <property type="gene designation" value="CAGL0F07073g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07073g"/>
    <dbReference type="eggNOG" id="KOG0877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FU18"/>
    <dbReference type="OMA" id="PYEEWSD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0130872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="253" mass="27345" checksum="DBBE0546E462F035" modified="2004-07-19" version="1">MSAPEGQQRRGGFGGRNRRGGNRRGGRNTEEKGWVPVTKLGRLVKAGKISSIEEIFLHSLPVKEFQIIDTLLPNLQDEVMNIKPVQKQTRAGQRTRFKAVVVVGDSNGHVGLGIKTAKEVAGAIRAGIIIAKLSVIPIRRGYWGTNLGQPHSLATKTTGKCGSVTVRLIPAPRGSGIVASPAVKKLMQLAGVEDVYTQSNGKTRTLENTLKAAFVAIGNTYAFLTPDLWTEHPLPLSPLDVYSDEASAQKKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU71</accession>
    <name>Q6FU71_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0F05797g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FU71">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU71"/>
    <dbReference type="KEGG" id="cgr:2887644"/>
    <dbReference type="CGD" id="CAL0131354">
        <property type="gene designation" value="CAGL0F05797g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05797g"/>
    <dbReference type="eggNOG" id="KOG1020">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_259053_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU71"/>
    <dbReference type="OMA" id="FNSRHVL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005729">
        <property type="term" value="C:2-micrometer circle DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090694">
        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061775">
        <property type="term" value="F:cohesin loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071169">
        <property type="term" value="P:establishment of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071168">
        <property type="term" value="P:protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070550">
        <property type="term" value="P:rDNA chromatin condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070058">
        <property type="term" value="P:tRNA gene clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="7">
        <location>
            <begin position="1183"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0131354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1470" mass="169836" checksum="EA4C45EA8CC60D61" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUE0</accession>
    <name>Q6FUE0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0F04213g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUE0"/>
    <dbReference type="FunCoup" id="Q6FUE0">
        <property type="interactions" value="1090"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUE0"/>
    <dbReference type="KEGG" id="cgr:2887686"/>
    <dbReference type="CGD" id="CAL0131198">
        <property type="gene designation" value="CAGL0F04213g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04213g"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_12_0_1"/>
    <dbReference type="InParanoid" id="Q6FUE0"/>
    <dbReference type="OMA" id="CWATIYK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015886">
        <property type="term" value="P:heme transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="113"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="213"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0131198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG59078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="306" mass="33300" checksum="326B44D387ABAFE7" modified="2004-07-19" version="1">MSETKKPQSNFAIDFLMGGVSAAVAKTAASPIERVKLLIQNQDEMIKQGSLDHRYKGIVDCFQRTARQEGIISFWRGNTANVIRYFPTQALNFAFKDQIKAMFGFKKEEGYAKWFAGNLASGGIAGGLSLMFVYSLDYARTRLAADAKSSKKGGERQFNGLVDVYKKTIASDGVAGLYRGFLPSVIGIVVYRGLYFGLYDSCKPLLLTGSLEGSFIASFLLGWVVTTGASTASYPLDTVRRRMMMTSGQAVKYKGAMDCLQKIVAAEGVSSLFKGCGANILRGVAGAGVISLYDQLQMILFGKKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUL5</accession>
    <name>Q6FUL5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0F02519g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446079.1">
        <property type="nucleotide sequence ID" value="XM_446079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUL5"/>
    <dbReference type="FunCoup" id="Q6FUL5">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUL5"/>
    <dbReference type="KEGG" id="cgr:2887967"/>
    <dbReference type="CGD" id="CAL0129621">
        <property type="gene designation" value="CAGL0F02519g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F02519g"/>
    <dbReference type="eggNOG" id="ENOG502QSY2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010084_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FUL5"/>
    <dbReference type="OMA" id="AHWRIAY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0129621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="832" mass="94826" checksum="706C3B10686CF164" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUQ2</accession>
    <name>Q6FUQ2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Late endosome and vacuole interface protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0F01617g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUQ2"/>
    <dbReference type="FunCoup" id="Q6FUQ2">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUQ2"/>
    <dbReference type="KEGG" id="cgr:2887956"/>
    <dbReference type="CGD" id="CAL0130924">
        <property type="gene designation" value="CAGL0F01617g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01617g"/>
    <dbReference type="eggNOG" id="KOG3269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094308_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FUQ2"/>
    <dbReference type="OMA" id="GRPKYDA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0130924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19772" checksum="2A82E4638D74DE9A" modified="2004-07-19" version="1">MAGKATKKQAASNSNTLNTLHKVAGPVLVLAFLRTVLGSNNTYIKFVMFNLPMCACLYILEKTGRPQYDSKGKVVREGMDLSQAGGMTEYMFDLIYLSIIANVGRIIFNTNKWWYLLLLCPIYVGYKLYSLKQQYFGSTPGPVIPDKMPEETKSKRQMKREKRGDDKVKYKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUW0</accession>
    <name>Q6FUW0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0F00231g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUW0"/>
    <dbReference type="FunCoup" id="Q6FUW0">
        <property type="interactions" value="816"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUW0"/>
    <dbReference type="KEGG" id="cgr:2887716"/>
    <dbReference type="CGD" id="CAL0129539">
        <property type="gene designation" value="CAGL0F00231g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00231g"/>
    <dbReference type="eggNOG" id="KOG0767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039456_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FUW0"/>
    <dbReference type="OMA" id="KMYIEEG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="110"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0129539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="32513" checksum="399B2541C2490369" modified="2004-07-19" version="1">MSNQLPQYSYSDYAKFALAGAIGCGSTHSSMVPIDVVKTRIQLEPTVYNKGMVGSFRKIIAEEGAGALLTGFGPTLLGYSIQGAFKFGGYEVFKKFFIDTLGYDTAARYKNSVYIGSAAAAEFLADIALCPLEATRIRLVSQPTFANGLVGGFSRILKEEGVGSFYSGFTPILFKQIPYNIAKFLVFERASELYFSLAPPKDTLSQTSLTAINLLSGLTAGLAAAIVSQPADTLLSKVNKTSKAPGQSTVGLLFQLAKQLGFVGSFAGLPTRLVMVGTLTSLQFGIYGQLKKSLGCAPTIEIAGGGH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVD3</accession>
    <name>HIR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein HIR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HIR1</name>
        <name type="ordered locus">CAGL0E02805g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445811.1">
        <property type="nucleotide sequence ID" value="XM_445811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVD3"/>
    <dbReference type="SMR" id="Q6FVD3"/>
    <dbReference type="FunCoup" id="Q6FVD3">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVD3"/>
    <dbReference type="EnsemblFungi" id="CAGL0E02805g-T">
        <property type="protein sequence ID" value="CAGL0E02805g-T-p1"/>
        <property type="gene ID" value="CAGL0E02805g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887422"/>
    <dbReference type="KEGG" id="cgr:2887422"/>
    <dbReference type="CGD" id="CAL0129108">
        <property type="gene designation" value="CAGL0E02805g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02805g"/>
    <dbReference type="eggNOG" id="KOG0973">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004372_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FVD3"/>
    <dbReference type="OMA" id="KRFDVHQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905268">
        <property type="term" value="P:negative regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000290">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001073">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0156">Chromatin regulator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000286406" description="Protein HIR1">
        <location>
            <begin position="1"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="129"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="171"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="224"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="292"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="840" mass="94224" checksum="6BE1898D760BA273" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVF1</accession>
    <name>Q6FVF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0E02387g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVF1"/>
    <dbReference type="FunCoup" id="Q6FVF1">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVF1"/>
    <dbReference type="KEGG" id="cgr:2887544"/>
    <dbReference type="CGD" id="CAL0128744">
        <property type="gene designation" value="CAGL0E02387g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02387g"/>
    <dbReference type="eggNOG" id="KOG3177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079653_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FVF1"/>
    <dbReference type="OMA" id="IDGPFKY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140104">
        <property type="term" value="F:molecular carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="46"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0128744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG58712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="195" mass="22475" checksum="518DE063793990D2" modified="2004-07-19" version="1">MSYVGVRCLNRSLLRPFGTRGFFDQLNPFHEIKTQKYVLPKIIQGTPSQVYDVVSEVSKYHEFIPYCEDSFVNERDDSNKPKVAGLRVGFKQYDERFVCDVDCKSKVSGKEVYVVRAESLSHNLFDILSSQWTISTHPTRKDASTVELLLKFKFKSRLYNSISSIFAKSVTELVMDAFARRVYHLKKAAVLENPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVG8</accession>
    <name>Q6FVG8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S16a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0E01991g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. eS19 is required for proper maturation of the small (40S) ribosomal subunit. Binds to 40S pre-ribosomal particles, probably required after association of NOC4 but before association of ENP1, TSR1 and RIO2 with 20/21S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVG8"/>
    <dbReference type="FunCoup" id="Q6FVG8">
        <property type="interactions" value="889"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVG8"/>
    <dbReference type="KEGG" id="cgr:2887407"/>
    <dbReference type="CGD" id="CAL0128652">
        <property type="gene designation" value="CAGL0E01991g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01991g"/>
    <dbReference type="eggNOG" id="KOG3411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108559_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FVG8"/>
    <dbReference type="OMA" id="WAPFVKT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018277">
        <property type="entry name" value="Ribosomal_eS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00628">
        <property type="entry name" value="RIBOSOMAL_S19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00055140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0128652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG58695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="144" mass="15848" checksum="C16396E1689F6356" modified="2004-07-19" version="1">MPGVSVRDVAAQDFINAYASFLQRQGKLEVPGYVDIVKTSAGNEMPPQDSEGWFYKRAASVARHIYLRKEVGVGKLNKLYGNAKSRGARPSHHADASGSINRRVLQALEKIGVVELSPKGGRRISENGQRDLDRIAAQTLEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVN5</accession>
    <name>Q6FVN5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0E00495g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445709.1">
        <property type="nucleotide sequence ID" value="XM_445709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVN5"/>
    <dbReference type="FunCoup" id="Q6FVN5">
        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887528"/>
    <dbReference type="CGD" id="CAL0128686">
        <property type="gene designation" value="CAGL0E00495g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00495g"/>
    <dbReference type="eggNOG" id="KOG1296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114688_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVN5"/>
    <dbReference type="OMA" id="TAHFVWR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0128686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="183" mass="20713" checksum="34B593E177DEAEEE" modified="2004-07-19" version="1">MLYLSMSGTLSENIVRVYPRDTEQSIAEYSFDITCTHCREAHGSPVFINAYEKHEMAGSRGETSFTMKCKFCGNEMSINLSHFEEALWNSEAESYDSGSITTSRKKHGIKNVSGNAGLLLQLDCRGCDISKFNPQNITFVVELQQGKMECIIEEGEDEWYDYDDNQGEEVSITEIKFDIIKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVT9</accession>
    <name>Q6FVT9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0D05654g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445655.1">
        <property type="nucleotide sequence ID" value="XM_445655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVT9"/>
    <dbReference type="KEGG" id="cgr:2887189"/>
    <dbReference type="CGD" id="CAL0128295">
        <property type="gene designation" value="CAGL0D05654g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05654g"/>
    <dbReference type="HOGENOM" id="CLU_871519_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVT9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274237" evidence="2">
        <location>
            <begin position="20"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="319" mass="37367" checksum="8296CF5DA62E76DA" modified="2004-07-19" version="1">MRMVRSTLLCCLWFTTVICSLLQPLKLEIIQPVTYHKLERLFYRIEQIGIDGETFRIWTLSGYHNIANEQSNFKYLTTKFVDSFERVLALRGLATRNISLNSLKIQACIIDKIKTQELINTAVELDYLAVTNDIKINNTKYVIKVIFDNIAKNYLGYYLWRLEWLTQRNSQVTEQELYYIYTRVETMVSLVKDKLNQLYSLPLTKFMESVLIPMDGLNCNMSQVVDCLKKRRKKEECRDSKDHKCLESLFHLTFVTLIIPIPLVVLYRVCSVSAGYVCVEGIGVLGLLITKSLTSQFFYLLFTRVKHDCLKWLFEVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW14</accession>
    <name>Q6FW14_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAGL0D03784g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW14"/>
    <dbReference type="FunCoup" id="Q6FW14">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW14"/>
    <dbReference type="KEGG" id="cgr:2887014"/>
    <dbReference type="eggNOG" id="ENOG502S50X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089394_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW14"/>
    <dbReference type="OMA" id="RANYHNK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="162" mass="18225" checksum="1B41AB1729DFA4BE" modified="2004-07-19" version="1">MIQLLQLLADYDALLEQLSKSMHDGFNNISRANYHNKDALRGKYGKDYWDDGYVGQVMAEVMVSGKVDIVAKPKPVNVPAEKVKDKEAEQLRNRKQTKKIADAEITEETNRTRDYDPILMFGGGLSTPQTLRNAQSNFKGTLPIIVKLLNCKNSINAIINEN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW70</accession>
    <name>PFA3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Palmitoyltransferase PFA3</fullName>
            <ecNumber>2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Protein fatty acyltransferase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PFA3</name>
        <name type="ordered locus">CAGL0D02508g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Autopalmitoylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW70"/>
    <dbReference type="SMR" id="Q6FW70"/>
    <dbReference type="FunCoup" id="Q6FW70">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW70"/>
    <dbReference type="DNASU" id="2886970"/>
    <dbReference type="GeneID" id="2886970"/>
    <dbReference type="KEGG" id="cgr:2886970"/>
    <dbReference type="eggNOG" id="KOG1315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027721_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW70"/>
    <dbReference type="OMA" id="YTYFKVI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000212952" description="Palmitoyltransferase PFA3">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="59"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="210"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="DHHC" evidence="3">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="332" mass="38432" checksum="929FA622615E2318" modified="2004-07-19" version="1">MNLVNNFSKLFPRCLTTGLYLWSLYAIVVCIHVIRARVVLPLVFTIAMVALYTYAKLIYVGPGTTKEYSILRVYDLNAAESGFELPPEMLVKRSYTQKRNGRFRVCKSCSSWKPDRCHHCSTCNVCVLKMDHHCPWFAGCVGYRNQKFFIQFLIYCTVYSILVLILSSMEIYTWFKGEFFEVELINFTLLSLWLLALVVSISITIFTVFSISQVCQNQTTIELYSLRRYNEEVAFLNEFSNEPIKGTINIFDLGKKLINWEEVMGYSLIEWALPISRRPSSLDLEGSHSHGLFFNVNKNVSKTMNESVDLQDRLLRRLTPRSSLDVDRSNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW93</accession>
    <name>Q6FW93_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[RNA-polymerase]-subunit kinase</fullName>
            <ecNumber evidence="2">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0D02002g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="2"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW93"/>
    <dbReference type="FunCoup" id="Q6FW93">
        <property type="interactions" value="874"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW93"/>
    <dbReference type="KEGG" id="cgr:2887063"/>
    <dbReference type="CGD" id="CAL0127983">
        <property type="gene designation" value="CAGL0D02002g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D02002g"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_181_1_1"/>
    <dbReference type="InParanoid" id="Q6FW93"/>
    <dbReference type="OMA" id="WHELESR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000415">
        <property type="entry name" value="CMGC/CDK/CRK7 protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000588">
        <property type="entry name" value="CTD kinase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="221"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0127983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="553" mass="63695" checksum="C7533E263F6FDF08" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWE8</accession>
    <name>COX9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">COX9</name>
        <name type="ordered locus">CAGL0D00748g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445446.1">
        <property type="nucleotide sequence ID" value="XM_445446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWE8"/>
    <dbReference type="SMR" id="Q6FWE8"/>
    <dbReference type="FunCoup" id="Q6FWE8">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWE8"/>
    <dbReference type="EnsemblFungi" id="CAGL0D00748g-T">
        <property type="protein sequence ID" value="CAGL0D00748g-T-p1"/>
        <property type="gene ID" value="CAGL0D00748g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887216"/>
    <dbReference type="KEGG" id="cgr:2887216"/>
    <dbReference type="CGD" id="CAL0128513">
        <property type="gene designation" value="CAGL0D00748g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_D00748g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00748g"/>
    <dbReference type="eggNOG" id="ENOG502SBM8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196969_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWE8"/>
    <dbReference type="OMA" id="ASYWWWG"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000041765" description="Cytochrome c oxidase subunit 9, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_0000041766" description="Removed in mature form" evidence="1">
        <location>
            <begin position="58"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P07255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="60" mass="6816" checksum="BDB2685372A513AA" modified="2007-01-23" version="3" precursor="true">MSALAPITGTLKKRIITDIVIGFSLGGVMASYWWWGFHKNVIDRREAFYADLAEKKKAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWM6</accession>
    <name>Q6FWM6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sister chromatid cohesion protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0C04433g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWM6"/>
    <dbReference type="FunCoup" id="Q6FWM6">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWM6"/>
    <dbReference type="KEGG" id="cgr:2886772"/>
    <dbReference type="CGD" id="CAL0127580">
        <property type="gene designation" value="CAGL0C04433g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04433g"/>
    <dbReference type="eggNOG" id="KOG1213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_462364_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWM6"/>
    <dbReference type="OMA" id="IWLASNM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21791">
        <property type="entry name" value="Rad21_Rec8_M_ScScc1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="537"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="322"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0127580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="64571" checksum="4358441E68549350" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWP8</accession>
    <name>Q6FWP8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-1,3-mannosyltransferase MNT3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0C03916g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445346.1">
        <property type="nucleotide sequence ID" value="XM_445346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWP8"/>
    <dbReference type="FunCoup" id="Q6FWP8">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="CAZy" id="GT71">
        <property type="family name" value="Glycosyltransferase Family 71"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886911"/>
    <dbReference type="CGD" id="CAL0127222">
        <property type="gene designation" value="CAGL0C03916g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03916g"/>
    <dbReference type="eggNOG" id="ENOG502RZ48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015387_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FWP8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0127222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="72958" checksum="949FB48E89003620" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWZ6</accession>
    <name>Q6FWZ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">ISWI chromatin-remodeling complex ATPase ISW1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ISW1</name>
        <name evidence="17 18" type="ordered locus">CAGL0C01683g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445248.1">
        <property type="nucleotide sequence ID" value="XM_445248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWZ6"/>
    <dbReference type="FunCoup" id="Q6FWZ6">
        <property type="interactions" value="1224"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWZ6"/>
    <dbReference type="GeneID" id="2886964"/>
    <dbReference type="KEGG" id="cgr:2886964"/>
    <dbReference type="CGD" id="CAL0127538">
        <property type="gene designation" value="ISW1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C01683g"/>
    <dbReference type="eggNOG" id="KOG0385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000315_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FWZ6"/>
    <dbReference type="OMA" id="EFQFRES"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036436">
        <property type="term" value="C:Isw1a complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036437">
        <property type="term" value="C:Isw1b complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030874">
        <property type="term" value="C:nucleolar chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140750">
        <property type="term" value="F:nucleosome array spacer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903895">
        <property type="term" value="P:negative regulation of IRE1-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046832">
        <property type="term" value="P:negative regulation of RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001178">
        <property type="term" value="P:regulation of transcriptional start site selection at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000002">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000234">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="187"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="485"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="16">
        <location>
            <begin position="859"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1041"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="914"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1042"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1105"/>
            <end position="1115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0127538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG58154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1115" mass="130223" checksum="8C99FD5FEAAF010B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX02</accession>
    <name>Q6FX02_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0C01551g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX02"/>
    <dbReference type="STRING" id="284593.Q6FX02"/>
    <dbReference type="KEGG" id="cgr:2886956"/>
    <dbReference type="CGD" id="CAL0127650">
        <property type="gene designation" value="CAGL0C01551g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C01551g"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1250504_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX02"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000879">
        <property type="term" value="P:negative regulation of dipeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="73"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="75"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0127650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="221" mass="24863" checksum="A79A09BB98FB1590" modified="2004-07-19" version="1">MGENVRLPSIRSLLNDDAPYPRSNAMDISNITSGNTNTSTTTTNTTGTSASSISTTSTTSTTSTTTTPPINMMKKSKRRSNLPKDTIQILNQWLLDHIHNPYPTQQEKRDLLIKTGLTKIQLSNWFINVRRRKIFNDYYALTSNLPPELLQSMSSQNTPPTPTTTTHTPPVQDDGNPPVTIMSEDEFSKRFVQAPLTRRKKLIDRLEELKKLTNMANNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX58</accession>
    <name>Q6FX58_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0B00594g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444996.1">
        <property type="nucleotide sequence ID" value="XM_444996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX58"/>
    <dbReference type="FunCoup" id="Q6FX58">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886543"/>
    <dbReference type="CGD" id="CAL0127790">
        <property type="gene designation" value="CAGL0B00594g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B00594g"/>
    <dbReference type="eggNOG" id="ENOG502SB24">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149546_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FX58"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274275" evidence="2">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG57896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="65" mass="6300" checksum="458A99F7D6093784" modified="2004-07-19" version="1">MQFKNIVAAAIALGVASAANASNMSNKSNHSNVTTTKISTGAANSNALSAGVFGAAVAAGVAFLF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXA5</accession>
    <name>TYW4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>tRNA wybutosine-synthesizing protein 4</fullName>
            <shortName>tRNA-yW synthesizing protein 4</shortName>
            <ecNumber>2.1.1.290</ecNumber>
            <ecNumber>2.3.1.231</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Leucine carboxyl methyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">PPM2</name>
        <name type="synonym">TYW4</name>
        <name type="ordered locus">CAGL0B01485g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36903"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.1.1.290"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine + CO2 = wybutosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37119"/>
            <dbReference type="Rhea" id="RHEA-COMP:11844"/>
            <dbReference type="Rhea" id="RHEA-COMP:11847"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73544"/>
            <dbReference type="ChEBI" id="CHEBI:74275"/>
            <dbReference type="EC" id="2.3.1.231"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.290"/>
    <dbReference type="EC" id="2.3.1.231"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445034.1">
        <property type="nucleotide sequence ID" value="XM_445034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXA5"/>
    <dbReference type="SMR" id="Q6FXA5"/>
    <dbReference type="FunCoup" id="Q6FXA5">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXA5"/>
    <dbReference type="EnsemblFungi" id="CAGL0B01485g-T">
        <property type="protein sequence ID" value="CAGL0B01485g-T-p1"/>
        <property type="gene ID" value="CAGL0B01485g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886671"/>
    <dbReference type="KEGG" id="cgr:2886671"/>
    <dbReference type="CGD" id="CAL0127682">
        <property type="gene designation" value="CAGL0B01485g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B01485g"/>
    <dbReference type="eggNOG" id="KOG2918">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002761_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXA5"/>
    <dbReference type="OMA" id="FCILEQF"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46529:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13418">
        <property type="entry name" value="Beta-prop_TYW4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000226140" description="tRNA wybutosine-synthesizing protein 4">
        <location>
            <begin position="1"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="674" mass="76295" checksum="D00A86FA06C5369A" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXI7</accession>
    <name>Q6FXI7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="11">PAGM</shortName>
            <ecNumber evidence="4 11">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0B03597g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 11"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXI7"/>
    <dbReference type="FunCoup" id="Q6FXI7">
        <property type="interactions" value="664"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXI7"/>
    <dbReference type="KEGG" id="cgr:2886511"/>
    <dbReference type="CGD" id="CAL0127932">
        <property type="gene designation" value="CAGL0B03597g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03597g"/>
    <dbReference type="eggNOG" id="KOG2537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022890_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FXI7"/>
    <dbReference type="OMA" id="WEAYATK"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
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    </dbReference>
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        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
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    </dbReference>
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        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF02878">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
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    </dbReference>
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        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="34"/>
            <end position="84"/>
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            <begin position="104"/>
            <end position="169"/>
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            <begin position="170"/>
            <end position="289"/>
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            <begin position="303"/>
            <end position="442"/>
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    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="15">
        <location>
            <begin position="480"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="12">
        <location>
            <position position="61"/>
        </location>
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    <feature type="binding site" description="via phosphate group" evidence="14">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        <location>
            <position position="284"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="286"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="379"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <begin position="503"/>
            <end position="507"/>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="512"/>
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        <ligand>
            <name>substrate</name>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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            <dbReference type="PIRSR" id="PIRSR016408-3"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02878"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
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    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
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    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0127932"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG58028.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="540" mass="59852" checksum="A03B05F42A9BCD68" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXY3</accession>
    <name>Q6FXY3_CANGA</name>
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        <recommendedName>
            <fullName evidence="7">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0A00605g</name>
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    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
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    <dbReference type="InParanoid" id="Q6FXY3"/>
    <dbReference type="OMA" id="THEQEIC"/>
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        <property type="component" value="Chromosome A"/>
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    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="F:anaphase-promoting complex binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:1902426">
        <property type="term" value="P:deactivation of mitotic spindle assembly checkpoint"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:negative regulation of mitotic spindle pole body separation"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring contraction"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="Cdc20/Fizzy"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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        <property type="entry name" value="WD40_CDC20-Fz"/>
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        <property type="entry name" value="WD40_repeat_CS"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
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            <begin position="329"/>
            <end position="616"/>
        </location>
    </feature>
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        <location>
            <begin position="455"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="497"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="585"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="93"/>
            <end position="108"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0126837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG57690.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="640" mass="71006" checksum="79112DD5C66B4A25" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY20</accession>
    <name>Q6FY20_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0A01716g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY20"/>
    <dbReference type="FunCoup" id="Q6FY20">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY20"/>
    <dbReference type="KEGG" id="cgr:2886357"/>
    <dbReference type="CGD" id="CAL0126679">
        <property type="gene designation" value="CAGL0A01716g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01716g"/>
    <dbReference type="eggNOG" id="KOG4003">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_0_1"/>
    <dbReference type="InParanoid" id="Q6FY20"/>
    <dbReference type="OMA" id="DFVDSWP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904524">
        <property type="term" value="P:negative regulation of DNA amplification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019358">
        <property type="term" value="P:nicotinate nucleotide salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
        <property type="entry name" value="nicotinamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="3"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0126679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG57733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="211" mass="24422" checksum="06025B8FC4C59556" modified="2004-07-19" version="1">MKTLLVIDVQNDFITPDHSMYVPQGEEVVSPIVELMKDPQWHRVVVSRDWHPQNHISFAKNHGVEDYTETTYKSPRPGDDSTQPATLWPVHCVQNTRGAQLAPDILELVNSKHIKIVDKGYLSNCEYYSAFNDTWEWHKTELDEYLKKHHTTEVYVVGLALDFCVKNTAISAAKLGYDTTILKDYTKPIYTDEDHQQQLEKDLKEHNVKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY33</accession>
    <name>Q6FY33_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PAL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0A02409g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY33"/>
    <dbReference type="FunCoup" id="Q6FY33">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY33"/>
    <dbReference type="KEGG" id="cgr:2886294"/>
    <dbReference type="CGD" id="CAL0126575">
        <property type="gene designation" value="CAGL0A02409g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02409g"/>
    <dbReference type="eggNOG" id="ENOG502QPHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041195_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FY33"/>
    <dbReference type="OMA" id="FPIDGPN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0126575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG57762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49102" checksum="1B8C95DE3BE37517" modified="2004-07-19" version="1">MTGRPFSVNNPFRSAGMETRYQHDQQYQEWVRGNTSPSRGGSVSPPLGMAEKPVPVRQNTNPFLDDGDMHDSGHMGAPVQPVQPVHSPPQGYGKALSAEEEKEQLRQKYQRDREREERPSHRRDLPPSYEEVAGGRGKGYPREKESYSGNVHREHSRSSGHREEYSRSAERAPHRHHSHRRHQDNSSPAKKEKRKNKVATPKNVDTIDKLDVTGLFGGSFHHDGPFDAVTPHRNKNTKAAPVLAFPADGPNSTIGGVTSKKSAMNEVFGVEEDDDDNDLYRISGQVAGSTTSVNTKDAIKPNVGDIKQMDIKSKTEKIHGPTTVGLGSTTFLDGAPASAAAIRQDIKQHSHTNRSGVQRHKSLSQRLGIGSDSSRPSRSDSYKGAGLSRTRSGPTEERPHQARHNSSHADDDEEDVYLGLPTSSLKKSSGSKFMKRVRSLKVGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="144" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY46</accession>
    <name>Q6FY46_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Mitochondrial chaperone BCS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0A02992g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY46"/>
    <dbReference type="FunCoup" id="Q6FY46">
        <property type="interactions" value="1187"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY46"/>
    <dbReference type="KEGG" id="cgr:2886299"/>
    <dbReference type="CGD" id="CAL0126529">
        <property type="gene designation" value="CAGL0A02992g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02992g"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010189_6_2_1"/>
    <dbReference type="InParanoid" id="Q6FY46"/>
    <dbReference type="OMA" id="WMTLYQR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="15">
        <location>
            <begin position="59"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="259"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0126529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG57789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="50913" checksum="0770F6994AB412FD" modified="2004-07-19" version="1">MNSGNGQSTLPPDAPTTGADTIGNELTSTLASGEKGTIRSLIDSAMQNNPYFAAGGGLMLLGTGLALAKSGMVKASRLAYKQMIVDLEIQSRDKSYSWFLSWMSKHPQRISKHLSVRTSYIQHDNGSVSTKFSLVPGPGNHWIRYKGAFIRIKRERSAKMVDISNGTPFETVTLTTLYRDRHLFQDILNEAKDIALKTTAGKTVIYTSFGPEWRKFGQPKAKRLLPSVVLDKGIKEDIIEDVHDFMKNGKWYSDRGIPYRRGYLLYGPPGSGKTSFIQALAGELDYNICILNLSENNLTDDRLNHLMNNMPERSILLLEDIDAAFNKREQTGEQGFHSAVTFSGLLNALDGVTSSEETITFMTTNHPEKLDKAIMRPGRIDYKVFIGNATSYQIEKMFLKFYPGEVNNCKKFVEAVESLGSSVSTAQLQGLFVMNKDDPESAIKMVHTMKTNEEFVV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1997-11-01" modified="2025-06-18" version="163" xmlns="https://uniprot.org/uniprot">
    <accession>Q00372</accession>
    <accession>Q6FJ61</accession>
    <name>SNF1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Carbon catabolite-derepressing protein kinase</fullName>
            <ecNumber>2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SNF1</name>
        <name type="ordered locus">CAGL0M08910g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1996" name="Infect. Immun." volume="64" first="5269" last="5273">
            <title>Disruption of the SNF1 gene abolishes trehalose utilization in the pathogenic yeast Candida glabrata.</title>
            <authorList>
                <person name="Petter R."/>
                <person name="Kwon-Chung K.J."/>
            </authorList>
            <dbReference type="PubMed" id="8945576"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 90030 / DSM 11226 / NCCLS 84</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential for release from glucose repression. It interacts and has functional relationship to the regulatory protein SNF4. Could phosphorylate CAT8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1"/>
    <dbReference type="EMBL" id="L78130">
        <property type="protein sequence ID" value="AAB48642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449733.1">
        <property type="nucleotide sequence ID" value="XM_449733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q00372"/>
    <dbReference type="SMR" id="Q00372"/>
    <dbReference type="FunCoup" id="Q00372">
        <property type="interactions" value="1165"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q00372"/>
    <dbReference type="EnsemblFungi" id="CAGL0M08910g-T">
        <property type="protein sequence ID" value="CAGL0M08910g-T-p1"/>
        <property type="gene ID" value="CAGL0M08910g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891294"/>
    <dbReference type="KEGG" id="cgr:2891294"/>
    <dbReference type="CGD" id="CAL0136473">
        <property type="gene designation" value="SNF1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M08910g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08910g"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_59_3_1"/>
    <dbReference type="InParanoid" id="Q00372"/>
    <dbReference type="OMA" id="SKTKWHF"/>
    <dbReference type="BRENDA" id="2.7.11.1">
        <property type="organism ID" value="1113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000144">
        <property type="term" value="C:cellular bud neck septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005641">
        <property type="term" value="C:nuclear envelope lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004679">
        <property type="term" value="F:AMP-activated protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061762">
        <property type="term" value="P:CAMKK-AMPK signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071940">
        <property type="term" value="P:fungal-type cell wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010920">
        <property type="term" value="P:negative regulation of inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900436">
        <property type="term" value="P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000222">
        <property type="term" value="P:positive regulation of pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000217">
        <property type="term" value="P:regulation of invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090606">
        <property type="term" value="P:single-species surface biofilm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000544">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000017">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000086667" description="Carbon catabolite-derepressing protein kinase">
        <location>
            <begin position="1"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="388"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="45"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB48642." evidence="5" ref="1">
        <original>I</original>
        <variation>S</variation>
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB48642." evidence="5" ref="1">
        <original>E</original>
        <variation>D</variation>
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB48642." evidence="5" ref="1">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB48642." evidence="5" ref="1">
        <original>E</original>
        <variation>H</variation>
        <location>
            <position position="497"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAB48642." evidence="5" ref="1">
        <original>K</original>
        <variation>N</variation>
        <location>
            <position position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="612" mass="70209" checksum="4532C99E39709238" modified="2004-08-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIK0</accession>
    <name>Q6FIK0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Family 17 glucosidase SCW4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MP65</name>
        <name evidence="16 17" type="ordered locus">CAGL0M13805g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIK0"/>
    <dbReference type="SMR" id="Q6FIK0"/>
    <dbReference type="STRING" id="284593.Q6FIK0"/>
    <dbReference type="CAZy" id="GH17">
        <property type="family name" value="Glycoside Hydrolase Family 17"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891235"/>
    <dbReference type="CGD" id="CAL0137403">
        <property type="gene designation" value="MP65"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13805g"/>
    <dbReference type="eggNOG" id="ENOG502QTKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027285_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FIK0"/>
    <dbReference type="OMA" id="KRTMITE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000111">
        <property type="entry name" value="Soluble cell wall protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF14">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273998" description="Family 17 glucosidase SCW4" evidence="15">
        <location>
            <begin position="19"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="68"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0137403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG62924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="38715" checksum="F6FD44E171772C62" modified="2004-07-19" version="1">MQFSKIITALSIAGAVIAAPANVHHEHKNKRDVVTKTVHNQVTVTAGAPPAVNTGLLKEDAVLGSSNEASAPVASSQAPAQQAAAPQSEAASPAPASSSQAAASSSAPKSSGSSSSFSGSAKGITYSPYNADGSCRSASDVASDLAKLSSYSMIRLYGVDCNQVENVFKAKAAGQKLFLGIFFVDQIQAGVDTMKAAVESYGSWDDVYTVSIGNELVNGGQATPDQVGQYVATGRSALKAAGYSGPVVSVDTFIAVINNPALCQYSDYMAVNAHAYFDQNTVAEDAGTWLVQQIQRVWTACDGKKDVLITESGWPSQGETLGVAVASKQNQEAAIASIEKACGDDTILFTAFNDYWKADGPYNCEKYWGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIL5</accession>
    <name>Q6FIL5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0M13475g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIL5"/>
    <dbReference type="FunCoup" id="Q6FIL5">
        <property type="interactions" value="1092"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIL5"/>
    <dbReference type="KEGG" id="cgr:2891220"/>
    <dbReference type="CGD" id="CAL0136571">
        <property type="gene designation" value="CAGL0M13475g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13475g"/>
    <dbReference type="eggNOG" id="KOG0213">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002242_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FIL5"/>
    <dbReference type="OMA" id="LVMNYVW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140727">
        <property type="term" value="P:siRNA-mediated pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="8">
        <location>
            <begin position="705"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="920" mass="103413" checksum="228A6E50C14EA736" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ74</accession>
    <name>Q6FJ74_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">CAGL0M08624g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ74"/>
    <dbReference type="FunCoup" id="Q6FJ74">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ74"/>
    <dbReference type="KEGG" id="cgr:2891281"/>
    <dbReference type="eggNOG" id="KOG2713">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_1_3_1"/>
    <dbReference type="InParanoid" id="Q6FJ74"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG62696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="337" mass="38180" checksum="031F8C034D4B97B6" modified="2004-07-19" version="1">MVQPTGKFHLGNYLGATRVWKDLCDIKQPGQRLIFGVADLHAITIPKPDAAQFKQLRREAIASILAVGVDPARASIMYQSAIPAHSQLYWLLSTVAPMGYLNRMTQWKSKSNLREDKDATAKELGEVKLGLFGYPVLQAADILLYKATHVPVGDDQVQHLELTRTLAENFNKLYKKQVFPLPRTLLAPTKKILSLTHDTKKMSKSDPNQDGVIYVNDPPETIIRKIKKARTDSITDKFYYDPVHRPGLSNLINIVSGITKQPVHAVEQELQKFDNYRDLKAHVSEVIIEELRVPREKFHQYMEDPQFLDDTVQQGTQRASEIAASTMKETMQTMGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ80</accession>
    <name>Q6FJ80_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell wall mannoprotein PIR1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PIR3</name>
        <name evidence="10 11" type="ordered locus">CAGL0M08492g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PIR protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449714.1">
        <property type="nucleotide sequence ID" value="XM_449714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ80"/>
    <dbReference type="FunCoup" id="Q6FJ80">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ80"/>
    <dbReference type="GeneID" id="2891274"/>
    <dbReference type="KEGG" id="cgr:2891274"/>
    <dbReference type="CGD" id="CAL0136553">
        <property type="gene designation" value="PIR3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08492g"/>
    <dbReference type="eggNOG" id="ENOG502QQD8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039662_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ80"/>
    <dbReference type="OMA" id="IQHQTAK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051153">
        <property type="entry name" value="Yeast_CWMannoprotein_PIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000420">
        <property type="entry name" value="Yeast_PIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47254:SF1">
        <property type="entry name" value="CELL WALL MANNOPROTEIN CIS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00399">
        <property type="entry name" value="PIR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00929">
        <property type="entry name" value="PIR_REPEAT_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50256">
        <property type="entry name" value="PIR_REPEAT_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273294" description="Cell wall mannoprotein PIR1-like C-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="9">
        <location>
            <begin position="251"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0136553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="335" mass="34076" checksum="E695C0F65BD089B9" modified="2004-07-19" version="1">MQYKKSLAATALLASSGLAAYVPGNPWSTLTPSGTYKGGLTDYSSTFGIAVQPIATSSSVAKRAVSQIGDGQVQAATKTQAAPVSQIGDGQIQATTKTQAAPVSQIGDGQIQAATKTQAAPVSQIGDGQIQAATKTQAAPVSQIGDGQIQAATKTQAAPVSQIGDGQIQATTKTQAAPVSQIGDGQIQATTKTTQAASQIGDGQVQAATKTASAASQIADGQVQQNKDPKDPVGAVSCKVDGTLQMNLKGGILTDEKGRIGSIVANRQFQFDGPPPQAGAIYAAGWSLTPQGNLALGDSDVFYQCLSGNFYNLYDQSIGAQCHPVHLSAIDLVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJG3</accession>
    <name>Q6FJG3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L21-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0M06523g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJG3"/>
    <dbReference type="FunCoup" id="Q6FJG3">
        <property type="interactions" value="855"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJG3"/>
    <dbReference type="KEGG" id="cgr:2891679"/>
    <dbReference type="CGD" id="CAL0136879">
        <property type="gene designation" value="CAGL0M06523g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06523g"/>
    <dbReference type="eggNOG" id="KOG1732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103610_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJG3"/>
    <dbReference type="OMA" id="INYGDYV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00064933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0136879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18137" checksum="EF0F59334EA194C9" modified="2004-07-19" version="1">MGKSHGYRSRTRYMFQRDFRKHGAIALSTYLKVYKVGDIVDIKANGSIQKGMPHKFYQGKTGVVYNVTKSSVGVIVNKMVGNRYLEKRLNLRVEHVKHSKCRQEFLDRVKSNAAKRAEAKAQGKAVQLKRQPAQPREARVVSTEGNVPQTLAPVAYETFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJH2</accession>
    <name>Q6FJH2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M06325g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJH2"/>
    <dbReference type="STRING" id="284593.Q6FJH2"/>
    <dbReference type="KEGG" id="cgr:2891670"/>
    <dbReference type="CGD" id="CAL0137409">
        <property type="gene designation" value="CAGL0M06325g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06325g"/>
    <dbReference type="eggNOG" id="KOG0014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_416169_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJH2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="462"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="590"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="590"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="659" mass="71818" checksum="69BEB965C579FAB9" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJK6</accession>
    <name>EXO5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Exonuclease V, mitochondrial</fullName>
            <shortName>Exo V</shortName>
            <ecNumber>3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Defects in morphology protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">EXO5</name>
        <name type="synonym">DEM1</name>
        <name type="ordered locus">CAGL0M05577g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449588.1">
        <property type="nucleotide sequence ID" value="XM_449588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJK6"/>
    <dbReference type="FunCoup" id="Q6FJK6">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0M05577g-T">
        <property type="protein sequence ID" value="CAGL0M05577g-T-p1"/>
        <property type="gene ID" value="CAGL0M05577g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891636"/>
    <dbReference type="KEGG" id="cgr:2891636"/>
    <dbReference type="CGD" id="CAL0137347">
        <property type="gene designation" value="CAGL0M05577g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05577g"/>
    <dbReference type="eggNOG" id="ENOG502QR0P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019985_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJK6"/>
    <dbReference type="OMA" id="LQVMYYR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016610">
        <property type="entry name" value="Exo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013220">
        <property type="entry name" value="UCP013220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end status="unknown"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000285322" description="Exonuclease V, mitochondrial">
        <location>
            <begin status="unknown"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="503" mass="58260" checksum="67736AE7F9C37DDB" modified="2004-07-19" version="1" precursor="true">MTLRDVEKLRLWRLKIFRNQQPILRAKPPHASRKTQYLFQKIDNVKSQFGTDGKGDLLWQRDGMNPYHDLYDPGDLKTHRLSVTKLLTKSWCELRFAYDLYSRLPLFREAHLAAGERTHQKLENSEHTPVIRPQDIPQFSETVEIVEDDLHVLAASWAETITRLIHLFSSGDAREILCHGYLNKETNQLYDPMETEVWDPSQHILISGIIDHLTLTSKNGNLPLNNHHRSIDDSIAKLKNTRNEFAKNGLTIQISDVKTRTRKFIPPQESVQNATKLQLMYYRHFLLSLGTDSDNTYEMLLYNARIRGVDVDQPLNPANCLLIMIQMDGFVGDFVKLQNGDGFQFPKFDNAPISHSFTLADAKHHQFLQNINSHELAGQLLNGTFAKPITLRYFAMRLAQMYSMLTPLISEKLKVEYYHNNECFQEVEFVNDKKSLGESCRSASSFWFGKRAIEPVEATTFNYNQYCKHCDYRDHCAWIKDSLAKSTKLGDELTQIARRIHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJP3</accession>
    <name>Q6FJP3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M04675g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJP3"/>
    <dbReference type="FunCoup" id="Q6FJP3">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJP3"/>
    <dbReference type="KEGG" id="cgr:2891560"/>
    <dbReference type="CGD" id="CAL0136673">
        <property type="gene designation" value="CAGL0M04675g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04675g"/>
    <dbReference type="eggNOG" id="KOG1530">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FJP3"/>
    <dbReference type="OMA" id="FFCQMGR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01519">
        <property type="entry name" value="RHOD_HSP67B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="36"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="138" mass="15268" checksum="40C1D80269D4DB2A" modified="2004-07-19" version="1">MWKRIVDAWNGNATSPSTPGVNTYDFEGMKKVAMQHDPSTVLVDVREPSEFSVVHIPGSINVPYRSHPEGFSLDPVTFKQTFGYEKPPVSNHLIFYCASGRRGSMAREVAAKNGYTNLSEYPGSMNDWVAKGGDRLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJX8</accession>
    <name>Q6FJX8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">YEATS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ANC1</name>
        <name evidence="8 9" type="ordered locus">CAGL0M02739g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJX8"/>
    <dbReference type="FunCoup" id="Q6FJX8">
        <property type="interactions" value="560"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJX8"/>
    <dbReference type="KEGG" id="cgr:2891474"/>
    <dbReference type="CGD" id="CAL0137505">
        <property type="gene designation" value="ANC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02739g"/>
    <dbReference type="eggNOG" id="KOG3149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078004_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJX8"/>
    <dbReference type="OMA" id="GEFDMTI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990468">
        <property type="term" value="C:NuA3b histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1970:FF:000006">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016665">
        <property type="entry name" value="Sas5/TAF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016551">
        <property type="entry name" value="SAS5/TFIID_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0137505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="241" mass="27071" checksum="48F97E3515E857FF" modified="2004-07-19" version="1">MVASTKRTIRIKTEQHILPDVPPVENFPVRQWSIEIALLDEEGKEMPATIFDKVVYHLHPTFANPNRTFNEPPFKIVEQGWGGFPLDISLYFLEKGGERKISHDLNFLQESYEVDHVIQVPLNKPTLTAELAKSGFTEDTSSGSKRKMTGSNTGAESKTKKAKTTTASTIKGNVDLEKLAFGLTKLNEDDLVGVVQMVTDNKTPEMNVTNNVEEGEFIIDLYSLPEGLLKSLWEYVKKNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJY2</accession>
    <name>Q6FJY2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0M02651g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJY2"/>
    <dbReference type="FunCoup" id="Q6FJY2">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJY2"/>
    <dbReference type="KEGG" id="cgr:2891470"/>
    <dbReference type="CGD" id="CAL0137313">
        <property type="gene designation" value="CAGL0M02651g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02651g"/>
    <dbReference type="eggNOG" id="ENOG502QQGC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010748_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJY2"/>
    <dbReference type="OMA" id="TRCVKRN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="192"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0137313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG62438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="462" mass="52280" checksum="9195A1BCE41626B0" modified="2004-07-19" version="1">MEEPAAKKQKKLYKSCIFCRRSHVNCDHQRPCSRCIKREIGHLCVADENVSNIQSQYQYKNSMSPIGSTEIPNAEINIGDETRAIQGSNSSVYGTETPISSSNNNLLLPPQPNFVSENVGSEFSSLNEFLMMLENPIPGESENTSQSNKEQERTAHSNMEDSIENTQEQTDNNEGIIGSVSVNQEISQDINEASSKANGTKTVNDGQGQEQDQEHNRQKLNKQESSNSKAQSDKYDDTPTSKEQFFLTAADPSTEMNPVDRLKLVINAKLEAGLLKPYDYAKGYARLQEYMDKYMNDTNKQRILKPLMSIRPAFRTIAKSLKDVDLVLVEESFERMLLSYDRVFTSMSMPACLWRRTGEIYRANKEFASLVDCTVDDLRDGKLAIYELMTEESAVNFWEKYGSIAFDKGQKAVLTSCSLRTKDGLKKRPCCFSFTIRRDRYNIPICIVGNFIPLSPTRDHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJZ0</accession>
    <name>Q6FJZ0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L37</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">RP47</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">YL37</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M02497g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJZ0"/>
    <dbReference type="FunCoup" id="Q6FJZ0">
        <property type="interactions" value="918"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJZ0"/>
    <dbReference type="KEGG" id="cgr:2891463"/>
    <dbReference type="CGD" id="CAL0137465">
        <property type="gene designation" value="CAGL0M02497g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02497g"/>
    <dbReference type="eggNOG" id="KOG0887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100745_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FJZ0"/>
    <dbReference type="OMA" id="YRTNKHH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0137465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="107" mass="12139" checksum="6DD705D48E76C672" modified="2004-07-19" version="1">MAESHRLYVKGKHLSYQRSKSVNNPNVSLLQIEGVANPQEAQFYLGKRVAYVYRASKEVRGSKIRVMWGKITRTHGNSGVVRAKFRNNLPAKTFGASVRIFLYPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK78</accession>
    <name>Q6FK78_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0M00484g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK78"/>
    <dbReference type="FunCoup" id="Q6FK78">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK78"/>
    <dbReference type="KEGG" id="cgr:2891589"/>
    <dbReference type="CGD" id="CAL0136563">
        <property type="gene designation" value="CAGL0M00484g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00484g"/>
    <dbReference type="eggNOG" id="ENOG502QRN9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092544_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK78"/>
    <dbReference type="OMA" id="TYNDVHN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000310">
        <property type="term" value="F:xanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032265">
        <property type="term" value="P:XMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000033">
        <property type="entry name" value="Xanthine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363">
        <property type="entry name" value="HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43363:SF4">
        <property type="entry name" value="XANTHINE PHOSPHORIBOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0136563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="208" mass="23845" checksum="B7B8BB5CA57564AC" modified="2004-07-19" version="1">MSEEKIYISYNNIHKLCQKIAKQILEREERPDVIIAITGGGMIPARIIRSFLKVQGQKNIPIQAIGLSLYEDLGLGNTADVIGKEVIRTQWLDFGALDQHFDSLIGKKVLIVDEVDDTRTTLHYAVTELQKEVEEQQKRLNRLNEDTIFSIFVLHNKDKKKRAQLPAEMMDSGRYLAALTVPDKWLCYPWEAQDIEEHTILAKQQGND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2025-06-18" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK87</accession>
    <name>HIR3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HIR3</name>
        <name type="ordered locus">CAGL0M00286g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449357.1">
        <property type="nucleotide sequence ID" value="XM_449357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK87"/>
    <dbReference type="SMR" id="Q6FK87"/>
    <dbReference type="FunCoup" id="Q6FK87">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK87"/>
    <dbReference type="EnsemblFungi" id="CAGL0M00286g-T">
        <property type="protein sequence ID" value="CAGL0M00286g-T-p1"/>
        <property type="gene ID" value="CAGL0M00286g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891145"/>
    <dbReference type="KEGG" id="cgr:2891145"/>
    <dbReference type="CGD" id="CAL0136481">
        <property type="gene designation" value="HIR3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00286g"/>
    <dbReference type="eggNOG" id="ENOG502QQX4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001316_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK87"/>
    <dbReference type="OMA" id="WETWYRL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905268">
        <property type="term" value="P:negative regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000256197" description="Histone transcription regulator 3 homolog">
        <location>
            <begin position="1"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="1615" mass="188141" checksum="FBD58D912B9C978E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKJ3</accession>
    <name>Q6FKJ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CNA1</name>
        <name evidence="16 17" type="ordered locus">CAGL0L11110g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKJ3"/>
    <dbReference type="SMR" id="Q6FKJ3"/>
    <dbReference type="FunCoup" id="Q6FKJ3">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKJ3"/>
    <dbReference type="KEGG" id="cgr:2891026"/>
    <dbReference type="CGD" id="CAL0136126">
        <property type="gene designation" value="CNA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11110g"/>
    <dbReference type="eggNOG" id="KOG0375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_6_2_1"/>
    <dbReference type="InParanoid" id="Q6FKJ3"/>
    <dbReference type="OMA" id="YPAACNF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="186"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="436"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0136126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG62225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="575" mass="65143" checksum="548AF447C319ECE5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKJ8</accession>
    <name>Q6FKJ8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L11000g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKJ8"/>
    <dbReference type="FunCoup" id="Q6FKJ8">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKJ8"/>
    <dbReference type="KEGG" id="cgr:2891021"/>
    <dbReference type="CGD" id="CAL0135344">
        <property type="gene designation" value="CAGL0L11000g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11000g"/>
    <dbReference type="eggNOG" id="KOG4132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051874_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FKJ8"/>
    <dbReference type="OMA" id="IHGADTG"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="278" mass="31406" checksum="3E06FE81763F067A" modified="2004-07-19" version="1">MIFTKPMGHDSRLHRVLLLKNMVDGGNDPYTKKIQEHQDSFEEPIFLPLITHTNVPQNIISRFADRADNLQDDYDFLIITSQRSIECLNLPELKHIRNKLIDKPTYTVGPATSNFLSSLGFTDIRGGIHAGNGMKLASIIDNDYPAGGKALFLVGEIRKDIIPKYLRPRNFTVDEIIMYKTAELSDSIVWFKSYLDKCDWIVVFSPQGMSDILQYMKQYSKGARPFKIACIGPTTCEFLNSNGIEPDLVSPKPDANSLIAAIKEYEVISRLSHSNGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKK2</accession>
    <name>Q6FKK2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polyamine transporter 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TPO4</name>
        <name evidence="7 8" type="ordered locus">CAGL0L10912g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449242.1">
        <property type="nucleotide sequence ID" value="XM_449242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKK2"/>
    <dbReference type="FunCoup" id="Q6FKK2">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKK2"/>
    <dbReference type="GeneID" id="2891017"/>
    <dbReference type="KEGG" id="cgr:2891017"/>
    <dbReference type="CGD" id="CAL0135500">
        <property type="gene designation" value="TPO4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10912g"/>
    <dbReference type="eggNOG" id="KOG0255">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008455_11_3_1"/>
    <dbReference type="InParanoid" id="Q6FKK2"/>
    <dbReference type="OMA" id="LMPETHK"/>
    <dbReference type="PHI-base" id="PHI:11183"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="72667" checksum="232B2C6AF5E4E7B2" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKK5</accession>
    <name>Q6FKK5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">18S rRNA (Guanine(1575)-N(7))-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0L10846g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKK5"/>
    <dbReference type="SMR" id="Q6FKK5"/>
    <dbReference type="FunCoup" id="Q6FKK5">
        <property type="interactions" value="1032"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKK5"/>
    <dbReference type="KEGG" id="cgr:2891050"/>
    <dbReference type="CGD" id="CAL0135124">
        <property type="gene designation" value="CAGL0L10846g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10846g"/>
    <dbReference type="eggNOG" id="KOG1541">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055194_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FKK5"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="52"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="206"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0135124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG62213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30618" checksum="216DEF39E610CB57" modified="2004-07-19" version="1">MSRPEELAPPEIFYNDSESKKYTASTRVQHIQAKMTLRSLELLNIEPNSFILDIGCGSGLSGEILTEEGHVWCGLDISPSMLATGLTRELEGDLMLQDMGQGIPFRPGTFDAAISISAIQWLCNADTSYNDPKRRLMRFFNGLFAALKKGGKFVAQFYPKNDDQVDQILQAAKVAGFSGGLVIDDPESKKNKKYYLVLSSGSPSNEEKQVNLEGVTMDATDVDSKEPRHKQSKTLLGESKKNFIMRKKELMRRRGRQVAHDSKFTGRKRRTKF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-04-05" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKN4</accession>
    <name>ETT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Enhancer of translation termination 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ETT1</name>
        <name type="ordered locus">CAGL0L10164g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for correct translation termination and probably involved in regulation of hypoxic gene expression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ETT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449210.1">
        <property type="nucleotide sequence ID" value="XM_449210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKN4"/>
    <dbReference type="SMR" id="Q6FKN4"/>
    <dbReference type="FunCoup" id="Q6FKN4">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKN4"/>
    <dbReference type="EnsemblFungi" id="CAGL0L10164g-T">
        <property type="protein sequence ID" value="CAGL0L10164g-T-p1"/>
        <property type="gene ID" value="CAGL0L10164g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891060"/>
    <dbReference type="KEGG" id="cgr:2891060"/>
    <dbReference type="CGD" id="CAL0135444">
        <property type="gene designation" value="CAGL0L10164g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L10164g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10164g"/>
    <dbReference type="eggNOG" id="ENOG502QPHX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050427_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKN4"/>
    <dbReference type="OMA" id="GIVHECD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000640">
        <property type="term" value="P:positive regulation of SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024318">
        <property type="entry name" value="Nro1/ETT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28290">
        <property type="entry name" value="ENHANCER OF TRANSLATION TERMINATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28290:SF1">
        <property type="entry name" value="ENHANCER OF TRANSLATION TERMINATION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12753">
        <property type="entry name" value="Nro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000406613" description="Enhancer of translation termination 1">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="404" mass="45683" checksum="5E50F96757ACD6AA" modified="2004-07-19" version="1">MAKRPLGLGKQKQNKKTKVESSSGEVSRESTPVASQIEVELADDVDADDELVQLKGLWQTYFDSDRDSEYVLNGIVHECDRLLREADKEGKIKELSDVFHAIYALALSELTIFKAGEEEDEKKKKEEIAQFFDNALERCSLGESDCGKSDLLDLVKAKVIIQRVPLEHMSALTVSSKSGLNLNTLVEDAKKHFKVSTKDLSLVYEVLEMFDDLLDITENFGHEEQIAEGLDSDDEEDLEPIQLDKKHPVYEMQQNLASNYKWLKEQLIALLGQLNKKDHAKLYHLTAKKIGELYLKDAEEPTNVYLSLAYDDDESKQSSKDCKESQASALKLVQNAIDYLDKAQIEDEPETWAQVAEAYIDLGNLHDNESSEQEKAYQTAETLLTKANTATHGKYDDILENLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL19</accession>
    <name>Q6FL19_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SIP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAGL0L06864g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIP5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL19"/>
    <dbReference type="STRING" id="284593.Q6FL19"/>
    <dbReference type="KEGG" id="cgr:2890820"/>
    <dbReference type="eggNOG" id="KOG2789">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_549800_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL19"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039301">
        <property type="entry name" value="Sip5/DA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31315:SF1">
        <property type="entry name" value="PROTEIN SIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="56965" checksum="1F3650AB9C7EB61E" modified="2004-07-19" version="1">MRLPARLDDRNGLDDNLFNSSDNEDEDEDDDDYLFVAQDANGQDHIQGAGSGISIGSRYVSGIKNSLVSTFAFRKESTAWKSVSELEKKKEHEMFYLLSRYNESVDGGYLAPFHYLPVNKYDYSVHTVRSLIIGRKLAPFYVPLDEFQENWSREQLLSAVTRLPLHERMSSLPKDHPVLKELEETSNLPVEDLGRDTIMNHIDKSLPFKKQKKLRQKIFHARNIRLRIKLQEEETEIIAGIPKKGSKVESIKEKYYPNDDLKIDIYSNVEECPICFFNMPAPLNKTKCCKQNLCTECFILMKRQRPQLNRISRTLTTTDNTEIDIARGIFSYTELDNNEGSRYRITIKVNSTPAKCPYCTQEDFAVTYNPPSSRRTGIGGVPPATYDPNVKPFINSNRKSHIISELDRITCVKSDDIRPYWQLASKQTRVLYRTHLNQRDLLARLANHEDQNNHSVSQSMSGYESTGLRHVEDSAAHIFSNTIPIIAQESNMSRPN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL63</accession>
    <name>CWC26_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor CWC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CWC26</name>
        <name type="ordered locus">CAGL0L05896g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CWC26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL63"/>
    <dbReference type="SMR" id="Q6FL63"/>
    <dbReference type="FunCoup" id="Q6FL63">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL63"/>
    <dbReference type="EnsemblFungi" id="CAGL0L05896g-T">
        <property type="protein sequence ID" value="CAGL0L05896g-T-p1"/>
        <property type="gene ID" value="CAGL0L05896g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890811"/>
    <dbReference type="CGD" id="CAL0136018">
        <property type="gene designation" value="CAGL0L05896g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05896g"/>
    <dbReference type="eggNOG" id="KOG2654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086127_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL63"/>
    <dbReference type="OMA" id="THEHHGS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051237">
        <property type="term" value="P:maintenance of RNA location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000079600" description="Pre-mRNA-splicing factor CWC26">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="235" mass="26405" checksum="D53E44F09636E8C9" modified="2004-07-19" version="1">MSLHDYLLKEYGPSDRKKKSKKVDSKSTAQKPNNEDVNSNANNPLRDNSEKSLWLSHGVNNIPGAPLSDNLTNKQKNGINIEPPSRTVLEPKTHNIETVFRNAQGHKIDVEAKTLDSDSGKRNSQEERIRILNMGEIQLAGLDGVSTISSKYTAEIRDNDPATEFDHNKGVNHQKISPLGRKLYAGTATENRFGILPGNKWDGVDRSNGYEKKWFKRQGELAESKIQEFTNSEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLC1</accession>
    <name>Q6FLC1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">sphingosine kinase</fullName>
            <ecNumber evidence="10">2.7.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0L04554g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(4R)-hydroxysphinganine + ATP = (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:64124"/>
            <dbReference type="ChEBI" id="CHEBI:64795"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.91"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51496"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:76941"/>
            <dbReference type="ChEBI" id="CHEBI:84410"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.91"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>sphinganine + ATP = sphinganine 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:57939"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.91"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15466"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.91" evidence="10"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLC1"/>
    <dbReference type="STRING" id="284593.Q6FLC1"/>
    <dbReference type="KEGG" id="cgr:2890643"/>
    <dbReference type="CGD" id="CAL0135838">
        <property type="gene designation" value="CAGL0L04554g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04554g"/>
    <dbReference type="eggNOG" id="KOG1116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013399_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FLC1"/>
    <dbReference type="OMA" id="QAWSRRI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008481">
        <property type="term" value="F:sphingosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000005">
        <property type="entry name" value="Sphingosine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="13">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0135838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG61943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="560" mass="62470" checksum="21009CF9430A214D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM56</accession>
    <name>Q6FM56_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Catalase</fullName>
            <ecNumber evidence="12">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CTA1</name>
        <name evidence="16 17" type="ordered locus">CAGL0K10868g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 13">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="12"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448688.1">
        <property type="nucleotide sequence ID" value="XM_448688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM56"/>
    <dbReference type="FunCoup" id="Q6FM56">
        <property type="interactions" value="1072"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM56"/>
    <dbReference type="PeroxiBase" id="5259">
        <property type="entry name" value="CglKat01"/>
    </dbReference>
    <dbReference type="GeneID" id="2890076"/>
    <dbReference type="KEGG" id="cgr:2890076"/>
    <dbReference type="CGD" id="CAL0134111">
        <property type="gene designation" value="CTA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10868g"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010645_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FM56"/>
    <dbReference type="OMA" id="KFRWNVF"/>
    <dbReference type="PHI-base" id="PHI:9713"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0349">Heme</keyword>
    <keyword evidence="8 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="18"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0134111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG61651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="507" mass="57760" checksum="48B767D79BA76D04" modified="2004-07-19" version="1">MSANPTNTSDVRGDRVVTNSTGYPYNDPFATQRVGQHGPLLMQDANLIDSLAHFNRERIPERNPHAHGSGAFGYFEVTDDITDICGSAMFSEIGKRTRFLTRFSTVGGEKGSADTARDPRGFATKFYTEEGNLDWVYNNTPIFFIRDPSKFPHFIHTQKRNPQTNLKDPNMFWDYLTTPENQVAVHQLMILFSDRGTPASYRHMNGYSGHTYKWSNKKGEWHYVQVHILTDQGIKNLTNDEAVEIAGKNPDYCQQDLYENIAKGNYPSWTVYIQTMTEEQAKKLPFSVFDLTKVWPHKDFPLRRVGKMVMNENPLNYFASIEQAAFSPANTVPYQEPSADPVLQSRLFAYADAHRYRLGANFHQIPVNCPYASKFFNPVIRDGPMNVDGNFGNEPNYYASNKQYQIPNQDRPIQQHQEVWNGPAQPFHWATSPGDIDFVQARDLYKVLGKQKDQQEHLAYNIGTHVAGADPEIQQRVIDMFSRVDEGLGANIRKEIEKNASAPTAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM79</accession>
    <name>Q6FM79_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase 2</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Deubiquitinating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin thioesterase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-specific-processing protease 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0K10252g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM79"/>
    <dbReference type="FunCoup" id="Q6FM79">
        <property type="interactions" value="96"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM79"/>
    <dbReference type="MEROPS" id="C19.003"/>
    <dbReference type="KEGG" id="cgr:2890115"/>
    <dbReference type="CGD" id="CAL0134789">
        <property type="gene designation" value="CAGL0K10252g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10252g"/>
    <dbReference type="eggNOG" id="KOG1863">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003155_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FM79"/>
    <dbReference type="OMA" id="MDIGDAY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010636">
        <property type="term" value="P:positive regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02666">
        <property type="entry name" value="Peptidase_C19J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000176">
        <property type="entry name" value="Ubiquitin-specific protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025305">
        <property type="entry name" value="UCH_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF6">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13446">
        <property type="entry name" value="RPT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="14">
        <location>
            <begin position="722"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="835"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1083"/>
            <end position="1110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0134789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG61628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1267" mass="146136" checksum="3AEE8C5655916E6E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="149" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMD6</accession>
    <name>Q6FMD6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0K08910g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMD6"/>
    <dbReference type="FunCoup" id="Q6FMD6">
        <property type="interactions" value="1263"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMD6"/>
    <dbReference type="KEGG" id="cgr:2890290"/>
    <dbReference type="CGD" id="CAL0134039">
        <property type="gene designation" value="CAGL0K08910g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08910g"/>
    <dbReference type="eggNOG" id="KOG0651">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FMD6"/>
    <dbReference type="OMA" id="DHEPCVI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000168">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="213"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="436" mass="48722" checksum="70CD2EC2B8F597E4" modified="2004-07-19" version="1">MSEEQDPLLAALNESNNNGGSGDNAAVSGEASAEPLEAAPEPEPVDPEKEAYEKALRHFKKKLMEHRRYDDQLKQRRQTIRDLEKIYDKTENDIKALQSIGQLIGEVMKELSEEKYIVKASSGPRYIVGVRNSVDRSKLKKGVRVTLDITTLTIMRILPRETDPLVYNMTSFEQGEISFEGIGGLTDQIRELREVIELPLKNPEIFQRVGIKPPKGVLLYGPPGTGKTLLAKAVAATIGANFIFSPASGIVDKYIGESARIIREMFAYAKEHEPCIIFMDEVDAIGGRRFSEGTSADREIQRTLMELLTQMDGFDNLGQTKIIMATNRPDTLDPALLRPGRLDRKIEIPLPNEAGRLEIFKIHTSKVKKSGEFDFDAAVKMSDGFNGADIRNCATEAGFFAIRDDRDHIIPEDLMKAVRKVAEVKKLEGTLEYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMM1</accession>
    <name>Q6FMM1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K06897g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448523.1">
        <property type="nucleotide sequence ID" value="XM_448523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMM1"/>
    <dbReference type="FunCoup" id="Q6FMM1">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMM1"/>
    <dbReference type="KEGG" id="cgr:2890411"/>
    <dbReference type="CGD" id="CAL0134299">
        <property type="gene designation" value="CAGL0K06897g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06897g"/>
    <dbReference type="eggNOG" id="ENOG502QRP4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011913_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMM1"/>
    <dbReference type="OMA" id="HIHPTKH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="856" mass="96770" checksum="4CDD01B2B7F1EE66" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMS0</accession>
    <name>Q6FMS0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0K05709g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMS0"/>
    <dbReference type="FunCoup" id="Q6FMS0">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMS0"/>
    <dbReference type="KEGG" id="cgr:2890467"/>
    <dbReference type="CGD" id="CAL0134959">
        <property type="gene designation" value="CAGL0K05709g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05709g"/>
    <dbReference type="eggNOG" id="KOG0588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005276_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FMS0"/>
    <dbReference type="OMA" id="DWEYMDK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990317">
        <property type="term" value="C:Gin4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:budding cell bud growth"/>
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    </dbReference>
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        <property type="term" value="P:mitotic morphogenesis checkpoint signaling"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:regulation of protein localization to cell division site"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:septin ring assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="Kcc4p_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serine/threonine-protein kinase HSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal kinase associated-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031850">
        <property type="entry name" value="Fungal_KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043024">
        <property type="entry name" value="KA1_sf_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16797">
        <property type="entry name" value="Fungal_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="369"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="432"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="819"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="884"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="377"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="834"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="888"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="908"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="951"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00047899"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0134959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG61435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1103" mass="124656" checksum="D4CBB0B05C2B7A24" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMY3</accession>
    <name>Q6FMY3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SCM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SCM4</name>
        <name evidence="7 8" type="ordered locus">CAGL0K04279g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448411.1">
        <property type="nucleotide sequence ID" value="XM_448411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMY3"/>
    <dbReference type="FunCoup" id="Q6FMY3">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMY3"/>
    <dbReference type="GeneID" id="2889990"/>
    <dbReference type="KEGG" id="cgr:2889990"/>
    <dbReference type="CGD" id="CAL0134775">
        <property type="gene designation" value="SCM4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04279g"/>
    <dbReference type="eggNOG" id="ENOG502S9YE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1467957_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMY3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051668">
        <property type="entry name" value="ATG33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37278:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="19085" checksum="1A4C45B70C053711" modified="2004-07-19" version="1">MTNPELITTTKCIGVTSLGLYAGLLTSTSLITSATPLDVLTGSLKNLLCKIGCWATAFGSVSTISLAVSYFLSEKPQRSNTRLAGALIAPITGLYLYASSLANHGCCPSKAKESGLPEGHPQVGADAPVCPFSKTTDGSNGSFHKGSIKSDKCYNALLCHLTVVTLTTCGVFAKSVFDGFQGLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-01" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN70</accession>
    <name>DSE1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein DSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Daughter-specific expression protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">DSE1</name>
        <name type="ordered locus">CAGL0K02277g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in cell wall metabolism and required for the separation of the mother and daughter cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448324.1">
        <property type="nucleotide sequence ID" value="XM_448324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN70"/>
    <dbReference type="SMR" id="Q6FN70"/>
    <dbReference type="FunCoup" id="Q6FN70">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN70"/>
    <dbReference type="EnsemblFungi" id="CAGL0K02277g-T">
        <property type="protein sequence ID" value="CAGL0K02277g-T-p1"/>
        <property type="gene ID" value="CAGL0K02277g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890301"/>
    <dbReference type="KEGG" id="cgr:2890301"/>
    <dbReference type="CGD" id="CAL0134215">
        <property type="gene designation" value="CAGL0K02277g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02277g"/>
    <dbReference type="eggNOG" id="ENOG502QTST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033098_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN70"/>
    <dbReference type="OMA" id="VKRFNHR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010969">
        <property type="term" value="P:regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000285346" description="Protein DSE1">
        <location>
            <begin position="1"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="68"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="346"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="398"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="567" mass="63856" checksum="0B2A531E939C42D1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNB6</accession>
    <name>Q6FNB6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K01243g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNB6"/>
    <dbReference type="FunCoup" id="Q6FNB6">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNB6"/>
    <dbReference type="KEGG" id="cgr:2890163"/>
    <dbReference type="CGD" id="CAL0134315">
        <property type="gene designation" value="CAGL0K01243g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01243g"/>
    <dbReference type="eggNOG" id="ENOG502RZ2K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076154_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FNB6"/>
    <dbReference type="OMA" id="KGHKHEL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="1">
        <location>
            <begin position="13"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="154" mass="18214" checksum="94581AEA10C76397" modified="2004-07-19" version="1">MSSKQYFEQLPKKLKDFFYKYPPSVKYAVKPTSTHAMDANPFLANKHPVTGKYHGAKYSARRMSDIYKLAYRYGVQDLLPQTNKQFFEEKYNNKKFMRGILTPKGHKHELNMEERMKRKAEGIANAEKILAEVKGSKYKRRMEKVQEKKRVGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FND5</accession>
    <name>Q6FND5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TRX2</name>
        <name evidence="12 13" type="ordered locus">CAGL0K00803g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448259.1">
        <property type="nucleotide sequence ID" value="XM_448259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FND5"/>
    <dbReference type="FunCoup" id="Q6FND5">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FND5"/>
    <dbReference type="GeneID" id="2890194"/>
    <dbReference type="KEGG" id="cgr:2890194"/>
    <dbReference type="CGD" id="CAL0134177">
        <property type="gene designation" value="TRX2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K00803g"/>
    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_14_0_1"/>
    <dbReference type="InParanoid" id="Q6FND5"/>
    <dbReference type="OMA" id="HIHYVTD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000104">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="9">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="9">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="9">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0134177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="103" mass="11171" checksum="D1AA6EBA8B487712" modified="2004-07-19" version="1">MVKQITSVSEFDSAIAVDKLVVVDFFATWCGPCKMIAPMIEKFAAEYSTADFYKLDVDELPEVAQKNEVSAMPTLVLFKNGKEVAKVVGANPAAIKQAIANNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNH6</accession>
    <name>Q6FNH6_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0J11616g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448218.1">
        <property type="nucleotide sequence ID" value="XM_448218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNH6"/>
    <dbReference type="KEGG" id="cgr:2889458"/>
    <dbReference type="CGD" id="CAL0129947">
        <property type="gene designation" value="CAGL0J11616g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11616g"/>
    <dbReference type="HOGENOM" id="CLU_2072840_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNH6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0129947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="118" mass="14284" checksum="EA7E01F4197EBEE0" modified="2004-07-19" version="1">MISIFSYSSANNLRDHQKCVDSYIPITVVMMPLDYYFSPSYAYFRKIFEGQLLHRLVVQLENKTVFLLLPEKCILIWPSYLKLQLFRGNDMKIIEGRIKIKIKIMIIKYNYWYRNEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNH7</accession>
    <name>Q6FNH7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J11594g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448217.1">
        <property type="nucleotide sequence ID" value="XM_448217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNH7"/>
    <dbReference type="STRING" id="284593.Q6FNH7"/>
    <dbReference type="KEGG" id="cgr:2889457"/>
    <dbReference type="CGD" id="CAL0132882">
        <property type="gene designation" value="CAGL0J11594g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11594g"/>
    <dbReference type="eggNOG" id="KOG4204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_312825_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNH7"/>
    <dbReference type="OMA" id="CDINIMS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF64">
        <property type="entry name" value="PAIRED AMPHIPATHIC HELIX PROTEIN PST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="3">
        <location>
            <begin position="288"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0132882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="937" mass="108981" checksum="A25CC206E2DE72BC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNK6</accession>
    <name>Q6FNK6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SUM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SUM1</name>
        <name evidence="2 3" type="ordered locus">CAGL0J10956g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
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                <person name="Neuveglise C."/>
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                <person name="Frangeul L."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
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                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
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                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448060.1">
        <property type="nucleotide sequence ID" value="XM_448060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNY4"/>
    <dbReference type="FunCoup" id="Q6FNY4">
        <property type="interactions" value="1151"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNY4"/>
    <dbReference type="GeneID" id="2889917"/>
    <dbReference type="KEGG" id="cgr:2889917"/>
    <dbReference type="CGD" id="CAL0133014">
        <property type="gene designation" value="UFD1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J08096g"/>
    <dbReference type="eggNOG" id="KOG1816">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037790_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FNY4"/>
    <dbReference type="OMA" id="VCMIETD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000837">
        <property type="term" value="C:Doa10p ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000839">
        <property type="term" value="C:Hrd1p ubiquitin ligase ERAD-L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030894">
        <property type="term" value="C:replisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072671">
        <property type="term" value="P:mitochondria-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.50:FF:000001">
        <property type="entry name" value="Ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000002">
        <property type="entry name" value="ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="5">
        <location>
            <begin position="19"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="120"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00074895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0133014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="332" mass="37093" checksum="1DA1164EDA73487D" modified="2004-07-19" version="1">MFSGFGFGNTGSVPIPQEFEDFFRCYPIAMMNDRIRKDDANFGGKIFLPPSALNRLSMLNIRYPMLFRLTSNESGKVTHGGVLEFIAEEGRVYLPQWMMETLNAQPGSLMKINSTDVPLGQFVKIEPQSTDFLDITDPKAVLENVLRNFSTLTIDDIIEISYNNKTYRIKVLEVKPESAAKSICVIETDLVTDFAPPVGYVEPDYKALKAEQDAKRKSAAIDPVKHSQGSMATRINYSNILNSTDSETIRFAGEGQKISGKPNKTSKGKQDISEIKISLDSEPARLDLPEGQLFFGFPLVLPKDENADEEENDKKVFIGEGQSLRKSKKSKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP38</accession>
    <name>DBP1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>ATP-dependent RNA helicase DBP1</fullName>
            <ecNumber>3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DBP1</name>
        <name type="ordered locus">CAGL0J06908g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes. Redundant to DED1, may be required in conditions in which DED1 expression is decreased.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448006.1">
        <property type="nucleotide sequence ID" value="XM_448006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP38"/>
    <dbReference type="SMR" id="Q6FP38"/>
    <dbReference type="STRING" id="284593.Q6FP38"/>
    <dbReference type="EnsemblFungi" id="CAGL0J06908g-T">
        <property type="protein sequence ID" value="CAGL0J06908g-T-p1"/>
        <property type="gene ID" value="CAGL0J06908g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889622"/>
    <dbReference type="KEGG" id="cgr:2889622"/>
    <dbReference type="CGD" id="CAL0133642">
        <property type="gene designation" value="CAGL0J06908g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06908g"/>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_16_3_1"/>
    <dbReference type="InParanoid" id="Q6FP38"/>
    <dbReference type="OMA" id="SYAGMQP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901195">
        <property type="term" value="P:positive regulation of formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000255988" description="ATP-dependent RNA helicase DBP1">
        <location>
            <begin position="1"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="169"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="386"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="535"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DEAD box">
        <location>
            <begin position="302"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="182"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="604" mass="66715" checksum="B7DF84C2855B3288" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP54</accession>
    <name>Q6FP54_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0J06534g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FP54">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP54"/>
    <dbReference type="KEGG" id="cgr:2889542"/>
    <dbReference type="CGD" id="CAL0133284">
        <property type="gene designation" value="CAGL0J06534g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06534g"/>
    <dbReference type="eggNOG" id="ENOG502QQFV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001029_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FP54"/>
    <dbReference type="OMA" id="HSWKFFA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031990">
        <property type="term" value="P:mRNA export from nucleus in response to heat stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041634">
        <property type="entry name" value="Nup188_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18378">
        <property type="entry name" value="Nup188_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="10">
        <location>
            <begin position="84"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="12">
        <location>
            <begin position="567"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore protein Nup188 C-terminal" evidence="11">
        <location>
            <begin position="1297"/>
            <end position="1665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0133284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG60941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1670" mass="188959" checksum="0CDA6A8DB0EF2FD5" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP91</accession>
    <name>Q6FP91_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J05698g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP91"/>
    <dbReference type="FunCoup" id="Q6FP91">
        <property type="interactions" value="95"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP91"/>
    <dbReference type="KEGG" id="cgr:2889802"/>
    <dbReference type="CGD" id="CAL0132874">
        <property type="gene designation" value="CAGL0J05698g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05698g"/>
    <dbReference type="eggNOG" id="ENOG502RZ0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072641_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FP91"/>
    <dbReference type="OMA" id="ADPYENT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0132874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="234" mass="26038" checksum="0973F9EC5A891ABC" modified="2004-07-19" version="1">MSGRRGAGSGGGARSLPFGLGYQDIGPNNIAEFPSLSLPVNGNVSSRDRSIALKYINFNAALRESPFFTGTLEAAEEGDNKNKKKGKRELVNNEGPSDGIARYSDKYLKKRKLGVSIDEHPFHLELFPKDLYAVMGINKKKLMTLSKFNNEDDIFTGSEQDEALGLSMLEKYKELAEEVDEEDENKKEEDGTEEPVDDEFDDEDDDDDYNAEKYFSGGDDDDIGEDDYGDEPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPV8</accession>
    <name>Q6FPV8_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J00561g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPV8"/>
    <dbReference type="FunCoup" id="Q6FPV8">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPV8"/>
    <dbReference type="KEGG" id="cgr:2889878"/>
    <dbReference type="CGD" id="CAL0129639">
        <property type="gene designation" value="CAGL0J00561g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J00561g"/>
    <dbReference type="eggNOG" id="KOG3033">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048756_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPV8"/>
    <dbReference type="OMA" id="AHWTNLS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR016184-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="293" mass="32307" checksum="6EAD709CE11C35E7" modified="2004-07-19" version="1">MLQVPFKQVNVFSGEPFKGNPVAVINCLDLDESNYLTDEEMQSIANWTNLSETTFIYKSQNPQADYKVRIFTPVSELPFAGHPTVGTCKAYLDIVGKPISGNYIVHQECAAGLVPIEIKDGIVSFSAPRVAPTELSDEVIAEYTKIVGHPYTHRPQMIDSGPQWVVYLVEDADTCYNINPNFQNLKLLNLDNDHSGVIIAGPRSDNEWEMRAFVPVLSVPEDPVCGSGAAAFIGHLQQRFQYKETTNVKITQGGRLNRNGLIVGQINLDNEKPVYKIGGVPVTVVDGTITVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ61</accession>
    <name>Q6FQ61_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">37S ribosomal protein S35, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0I08877g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ61"/>
    <dbReference type="FunCoup" id="Q6FQ61">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ61"/>
    <dbReference type="KEGG" id="cgr:2889012"/>
    <dbReference type="CGD" id="CAL0132634">
        <property type="gene designation" value="CAGL0I08877g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08877g"/>
    <dbReference type="eggNOG" id="ENOG502QVMS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_842157_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ61"/>
    <dbReference type="OMA" id="KYAMRQF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021036">
        <property type="entry name" value="Ribosomal_mS45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S35, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28158:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12298">
        <property type="entry name" value="Bot1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="39662" checksum="6081060B692E3089" modified="2004-07-19" version="1">MFRPAASGKSSSLLQGNICCYQQVRNLSRRRLAYPFYPFKRLGRQHPKKHDTNLKYAMRQFLGPKNYKGEYVMNTYFAVPNNHVPNYIKPDIERGQALRDPNTGKRLTERYDGALVDAPHNKRLEDVSERRQLQPFPSNPHCKTNYMVSEELKAQIYNDIETNGLSTQQVSHNYGLKIPRVEAIVKLMKVEKKWEKLNRISPDLKVMSETLYKMFPLFVPEVPANRENLSEIPVPQKALSSRFLTIAESQPFGPVDAAKVLELEPAVKTLEKLSTIGEHSEGHIEKKEHKKKVVYGELKEGERSVLKFTHAKVGEVGHRYGRVLRDNKKDRKIGFNELGQMVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQG9</accession>
    <name>Q6FQG9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0I06314g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQG9"/>
    <dbReference type="FunCoup" id="Q6FQG9">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889157"/>
    <dbReference type="CGD" id="CAL0132140">
        <property type="gene designation" value="CAGL0I06314g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06314g"/>
    <dbReference type="eggNOG" id="ENOG502R3QS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_429070_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQG9"/>
    <dbReference type="OMA" id="MHLKFND"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="623" mass="71451" checksum="74A0A0FC2130B5BF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQJ6</accession>
    <name>Q6FQJ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0I05720g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQJ6"/>
    <dbReference type="FunCoup" id="Q6FQJ6">
        <property type="interactions" value="857"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQJ6"/>
    <dbReference type="KEGG" id="cgr:2889343"/>
    <dbReference type="CGD" id="CAL0130496">
        <property type="gene designation" value="CAGL0I05720g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05720g"/>
    <dbReference type="eggNOG" id="KOG3296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042174_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQJ6"/>
    <dbReference type="OMA" id="TRFNYRW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0130496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="382" mass="41753" checksum="DD63FCE9DC0F2DB0" modified="2004-07-19" version="1">MSAPEVSKITAIPPISLNEDREKSSFWSANPLSSFVIDTYRQLHAHRQSLSLVNPGTVENLNKEVSRDVFLSQYFFTGLRADLNKAFTLNPAFQTSHTFSIGSTSLPNYAFSALFANDNLFMQGNIDNDFSLSGRMNYGWNKNNISKINLQIANGQPTMCQLEQDYQASDSSLNFKSLNPSISSNGTLTGVYVGSLLQSISPQLAVGLEVLYSRADAKTPADSGVSYLTRYVSPKQDWIFSGQLQANGALVASFWRKVAPNVEAGIETTLQAGMIPITDPVMGTPIGIQPTIEGSTTIGAKYEYRQSVYRGSVDSNGKIGCFLERKILPTLSVLFCGEIDQFKQESKIGCGLQFETAGNQELLMMQQGLDADGNPLQALPEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQN4</accession>
    <name>Q6FQN4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CHS3B</name>
        <name evidence="12 13" type="ordered locus">CAGL0I04840g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447460.1">
        <property type="nucleotide sequence ID" value="XM_447460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQN4"/>
    <dbReference type="STRING" id="284593.Q6FQN4"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="GeneID" id="2889367"/>
    <dbReference type="KEGG" id="cgr:2889367"/>
    <dbReference type="CGD" id="CAL0130418">
        <property type="gene designation" value="CHS3B"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04840g"/>
    <dbReference type="eggNOG" id="KOG2571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002572_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQN4"/>
    <dbReference type="OMA" id="NWADPAP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="930"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="958"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="11">
        <location>
            <begin position="276"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0130418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1064" mass="121330" checksum="08831EFBE6E4FE6B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQP0</accession>
    <name>Q6FQP0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">PNP/PMP oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PDX3</name>
        <name evidence="17 18" type="ordered locus">CAGL0I04708g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine 5'-phosphate + O2 + H2O = pyridoxal 5'-phosphate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447454.1">
        <property type="nucleotide sequence ID" value="XM_447454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQP0"/>
    <dbReference type="FunCoup" id="Q6FQP0">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQP0"/>
    <dbReference type="GeneID" id="2889361"/>
    <dbReference type="KEGG" id="cgr:2889361"/>
    <dbReference type="CGD" id="CAL0132580">
        <property type="gene designation" value="PDX3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04708g"/>
    <dbReference type="eggNOG" id="KOG2586">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032263_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FQP0"/>
    <dbReference type="OMA" id="AYFRTRP"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000010">
        <property type="entry name" value="Pyridoxine phosphate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="15">
        <location>
            <begin position="55"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="16">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0132580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG60391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="227" mass="26798" checksum="70C22D6AA590F27A" modified="2004-07-19" version="1">MSEKETTQQPIIFAPETYQYDKYSLNEGQLKDDPIDQFVEWFDDAKNDPRETLPEAITFSSAELPSGRVSSRVLLFKELDHRGFTIYSNWKTSGKAHDIATNPNVAINFFWRDLQRQIRIEGFSEHVNRETSERYFQTRPRGSKIGAWSSPQSTVLKDRNELEHIVQENENRFKGVEDVPCPDYWGGLRVVPLRIEFWQGRPSRLHDRFVYERKTEHDPWELHRIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQP8</accession>
    <name>Q6FQP8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-1,2-mannosyltransferase MNN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MNN2</name>
        <name evidence="12 13" type="ordered locus">CAGL0I04532g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MNN1/MNT family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447446.1">
        <property type="nucleotide sequence ID" value="XM_447446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQP8"/>
    <dbReference type="FunCoup" id="Q6FQP8">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQP8"/>
    <dbReference type="CAZy" id="GT71">
        <property type="family name" value="Glycosyltransferase Family 71"/>
    </dbReference>
    <dbReference type="GeneID" id="2889032"/>
    <dbReference type="KEGG" id="cgr:2889032"/>
    <dbReference type="CGD" id="CAL0130340">
        <property type="gene designation" value="MNN2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04532g"/>
    <dbReference type="eggNOG" id="ENOG502QQ16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013298_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FQP8"/>
    <dbReference type="OMA" id="KGYQYKA"/>
    <dbReference type="PHI-base" id="PHI:3794"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046354">
        <property type="term" value="P:mannan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000177">
        <property type="entry name" value="MNN5p Alpha-1,2-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31646:SF1">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE MNN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0130340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="70118" checksum="7BFB50B7ECB8A2F9" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQS4</accession>
    <name>Q6FQS4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PPH21</name>
        <name evidence="12 13" type="ordered locus">CAGL0I03938g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Exact function not known, phosphatase 2A performs an essential cellular function.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447420.1">
        <property type="nucleotide sequence ID" value="XM_447420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQS4"/>
    <dbReference type="FunCoup" id="Q6FQS4">
        <property type="interactions" value="1191"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQS4"/>
    <dbReference type="GeneID" id="2889092"/>
    <dbReference type="KEGG" id="cgr:2889092"/>
    <dbReference type="CGD" id="CAL0132122">
        <property type="gene designation" value="PPH21"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03938g"/>
    <dbReference type="eggNOG" id="KOG0371">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_8_1_1"/>
    <dbReference type="InParanoid" id="Q6FQS4"/>
    <dbReference type="OMA" id="CMKVRYP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990813">
        <property type="term" value="P:meiotic centromeric cohesion protection in anaphase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010515">
        <property type="term" value="P:negative regulation of induction of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="173"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0132122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG60357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="368" mass="41567" checksum="58258573869C545E" modified="2004-07-19" version="1">MDMDMDVPMHDAVDQLTPTEGNAEAANDSIGDEVDEAFKDAHPSQGAVLDSGKGGNKGFELNSSNINQLDQWIEHLGKCEILSEDDVSKLCKMAVEVLQFEENVQPINVPVTICGDVHGQFHDLIELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETVDQVRELNRIQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGFTFGQDISEQFNHTNDLSLVARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSVRPGEPTVSRKTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQT6</accession>
    <name>Q6FQT6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0I03674g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit p55 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQT6"/>
    <dbReference type="FunCoup" id="Q6FQT6">
        <property type="interactions" value="1275"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQT6"/>
    <dbReference type="KEGG" id="cgr:2889147"/>
    <dbReference type="CGD" id="CAL0132272">
        <property type="gene designation" value="CAGL0I03674g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03674g"/>
    <dbReference type="eggNOG" id="KOG1498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033860_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FQT6"/>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000070">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040896">
        <property type="entry name" value="RPN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18098">
        <property type="entry name" value="RPN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="233"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0132272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="445" mass="51935" checksum="46ACCC515BE81B8E" modified="2004-07-19" version="1">MSRDAPIKAEKDYTSVLKEEFPIIDKLAKSDANAALDKLLVLEKKTRQAADLTSSKDVLAKIVDVLVEKDNWDELDEQLTLLSKKHGQLKLSIQYMVQKIMQALDENKKIPLKTRIKTIETIRTVTENKIFVEVERARVTRELTNIRKEEGDIAKAADILCELQVETYGSMDMFEKIQFILEQMELSILKGDYSQATVFSRKILKKTFKNEKYESLKLQYYELLIKIGLHKNDYLEVAQYFQEIYETKSVKEDEEKWKPALSRMVYFLILAPYGNLQNDLIHKIQLDNNLKKLEQQESLVRLFTTKEFMKWPVVKKTYEPVLIQDTVAFGGKDNKHHWDELKDRVVEHNLRVISEYYTRITLARLNELLDLTESETETFISNLVNQGVIYAKVNRPAKIVNFEKPLNSCELLNEWSDNVNQLLENIETIGHLITKEEIMHGLKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQU3</accession>
    <name>Q6FQU3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I03520g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQU3"/>
    <dbReference type="FunCoup" id="Q6FQU3">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889180"/>
    <dbReference type="CGD" id="CAL0129618">
        <property type="gene designation" value="CAGL0I03520g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03520g"/>
    <dbReference type="eggNOG" id="ENOG502S2HK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148825_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQU3"/>
    <dbReference type="OMA" id="EGWLWNK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053092">
        <property type="entry name" value="Mitochondrial_unc_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048:SF1">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12261" checksum="6CE73D8DE7DF3958" modified="2004-07-19" version="1">MSNILSVFNPPPSRELDEEETRDCVPCQVMSTVFGIGFGSYLVSGRAFKYSEAEKKKGISLEEFNKRNPMWWRRSLKGLGSIFIIMGLARGTEGWLWNKEKEYKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQV8</accession>
    <name>Q6FQV8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I03168g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_447386.1"/>
    </dbReference>
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        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQV8"/>
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        <property type="gene designation" value="CAGL0I03168g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I03168g"/>
    <dbReference type="eggNOG" id="ENOG502QPR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005049_0_3_1"/>
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        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="20"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="622" mass="71590" checksum="2047BFE1E6D0835D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQW7</accession>
    <name>Q6FQW7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I02904g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQW7"/>
    <dbReference type="KEGG" id="cgr:2889139"/>
    <dbReference type="CGD" id="CAL0132256">
        <property type="gene designation" value="CAGL0I02904g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02904g"/>
    <dbReference type="eggNOG" id="ENOG502RYP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042838_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQW7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor TFIIIC subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014623">
        <property type="entry name" value="Tfc7/tau55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036802">
        <property type="entry name" value="Tau55_TFC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="279"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="430" mass="48874" checksum="8B81EA603E7E4573" modified="2004-07-19" version="1">MVVRTVYIARHGYRANWIIGAEVPPPPTGIAGDVQLAQHGIKQAHELGRFLLTLDDQPEMIFSSPFYRCLETSTPIAELLEVPVYIERGFSEWYRPDRPVIPVPADNELLSKYFHDTVRLEWHSQPAPSEKGETEEELYKRCHDALNNFIKQVEKKFPSVETIMIVTHGATKIALGLNLLQKPDCRCTIDDTHEYLRCGSCSLDKFELPSNAKETSNPEEDIDVLEETEPLKRNWMCTLNGHTEFLSRGEEMNWGFHLNVEAGSDADVKSRITTETAGKESVYVSVDIPSGNYKGKNVLDKKATLQYSGLEEHEPLVLINNKLYVGKWEKLVGTELAFPSTATVNKKNLRGGEDDESSSKGLNHILDEDIIADEFDNIKKEEDDKLAEDSDDSSIEKQKIPEERNELENKVTEKIYRIKDRLVLEEVEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQX0</accession>
    <name>Q6FQX0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAGL0I02838g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQX0"/>
    <dbReference type="FunCoup" id="Q6FQX0">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQX0"/>
    <dbReference type="KEGG" id="cgr:2889028"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02838g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_418554_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQX0"/>
    <dbReference type="Proteomes" id="UP000002428">
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
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            <begin position="614"/>
            <end position="641"/>
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    <sequence length="655" mass="70724" checksum="D5D20204919CB65E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQX4</accession>
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        <recommendedName>
            <fullName evidence="5">Protein BZZ1</fullName>
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        <name evidence="11 12" type="ordered locus">CAGL0I02750g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <text evidence="3">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
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        <text evidence="4">Belongs to the BZZ1 family.</text>
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        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
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            <end position="269"/>
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            <begin position="481"/>
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            <begin position="563"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="424"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="542"/>
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    </feature>
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            <begin position="172"/>
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            <begin position="470"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00074946"/>
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    </evidence>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50002"/>
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            <dbReference type="PROSITE" id="PS51741"/>
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    </evidence>
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            <dbReference type="EMBL" id="CAG60307.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
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    </evidence>
    <sequence length="619" mass="69246" checksum="BDD9968C015CA673" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR68</accession>
    <name>Q6FR68_CANGA</name>
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        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0I00528g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR68"/>
    <dbReference type="FunCoup" id="Q6FR68">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR68"/>
    <dbReference type="KEGG" id="cgr:2889083"/>
    <dbReference type="CGD" id="CAL0132094">
        <property type="gene designation" value="CAGL0I00528g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00528g"/>
    <dbReference type="eggNOG" id="KOG3454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104749_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR68"/>
    <dbReference type="OMA" id="HSYLTHD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0132094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="223" mass="26679" checksum="F19561806D54F1C9" modified="2004-07-19" version="1">MARYYCEYCHSYLTHDTLSVRKFHLMGKNHLRVRADYYRSQAIKEQELDRRRCLHGKRAKVYKTKKSEQGSINHNEKLSIKLLSRKEKKKKLRVDRVYKKELNNSKINDLSKVYLGSPGYNRVFIDPNRYDIGDTVKASRLPQRANKLQEQNKYKDRNELYQGYDKQLPHLEVPKMLNIWNTSQKLTNIYYDPSTFPKSSDEIRRMPKSRNATHYKSRQLQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRC2</accession>
    <name>Q6FRC2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Golgi apyrase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0H09746g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG60155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRC2"/>
    <dbReference type="FunCoup" id="Q6FRC2">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRC2"/>
    <dbReference type="KEGG" id="cgr:2888747"/>
    <dbReference type="CGD" id="CAL0131854">
        <property type="gene designation" value="CAGL0H09746g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09746g"/>
    <dbReference type="eggNOG" id="KOG1386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010246_3_3_1"/>
    <dbReference type="InParanoid" id="Q6FRC2"/>
    <dbReference type="OMA" id="TAYEVCF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043262">
        <property type="term" value="F:ADP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036384">
        <property type="term" value="F:CDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046036">
        <property type="term" value="P:CTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24039">
        <property type="entry name" value="ASKHA_NBD_YND1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF121">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATASE MIG-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="573"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="599"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="182"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0131854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="71834" checksum="2C83F4CCC3F76C4F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRE0</accession>
    <name>Q6FRE0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Complex III subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0H09328g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRE0"/>
    <dbReference type="FunCoup" id="Q6FRE0">
        <property type="interactions" value="356"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRE0"/>
    <dbReference type="KEGG" id="cgr:2888725"/>
    <dbReference type="CGD" id="CAL0129718">
        <property type="gene designation" value="CAGL0H09328g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09328g"/>
    <dbReference type="eggNOG" id="KOG3494">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171977_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FRE0"/>
    <dbReference type="OMA" id="ANAGMQW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.260:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12980">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX, SUBUNIT X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0129718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG60137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="69" mass="7668" checksum="7193931C2E9C2340" modified="2004-07-19" version="1">MSFSSLYKVLFKRNSIFVGTILASAFVFQGAFDTAVTSWYENHNKGKLWKDVKAQIGAAGGDEEDDDDE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRE5</accession>
    <accession>Q96X08</accession>
    <name>GMT_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>GDP-mannose transporter</fullName>
            <shortName>GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">VRG4</name>
        <name type="ordered locus">CAGL0H09196g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Yeast" volume="19" first="691" last="698">
            <title>Identification of a Candida glabrata homologue of the S. cerevisiae VRG4 gene, encoding the Golgi GDP-mannose transporter.</title>
            <authorList>
                <person name="Nishikawa A."/>
                <person name="Mendez B."/>
                <person name="Jigami Y."/>
                <person name="Dean N."/>
            </authorList>
            <dbReference type="PubMed" id="12185838"/>
            <dbReference type="DOI" id="10.1002/yea.854"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>FUNCTION</scope>
        <source>
            <strain>BG2</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF360395">
        <property type="protein sequence ID" value="AAK51897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447199.1">
        <property type="nucleotide sequence ID" value="XM_447199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRE5"/>
    <dbReference type="SMR" id="Q6FRE5"/>
    <dbReference type="FunCoup" id="Q6FRE5">
        <property type="interactions" value="580"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRE5"/>
    <dbReference type="GlyCosmos" id="Q6FRE5">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0H09196g-T">
        <property type="protein sequence ID" value="CAGL0H09196g-T-p1"/>
        <property type="gene ID" value="CAGL0H09196g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888653"/>
    <dbReference type="KEGG" id="cgr:2888653"/>
    <dbReference type="CGD" id="CAL0129728">
        <property type="gene designation" value="VRG4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09196g"/>
    <dbReference type="eggNOG" id="KOG1444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025360_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FRE5"/>
    <dbReference type="OMA" id="VWMLINC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005338">
        <property type="term" value="F:nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0762">Sugar transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000333516" description="GDP-mannose transporter">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="265"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="292"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="317"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAK51897." evidence="4" ref="1">
        <original>S</original>
        <variation>L</variation>
        <location>
            <position position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12185838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="324" mass="35761" checksum="98112C674B320566" modified="2004-07-19" version="1">MSELKSRIGNSGSIANSGPVSILCYCASSILMTVTNKFVVNTDGFNMFFVMLFAQSLVCTMCLMVLKMFGYAKYRPLNLIDVKNWLPISFLLVFMIFTSAKALKYMPVPIYTIFKNLTIILIAYGEVLFFGGSVTPMELSSFILMVLSSVVASLGDQQAAKIAQPLANNSILSPEYYWMFLNCICSASFVLIMRKRIKLTNFKDYDTMFYNNALALPILLGFSFLSEDWSSENLAQNFSGESLSAMIISGMTSVGISYCSGWCVRATSSTTYSMVGALNKLPIALAGLIFFDAPRNFLSIMSIFIGFASGLSYAVAKQKKVQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRP7</accession>
    <name>Q6FRP7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Endoplasmic oxidoreductin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21 22" type="ordered locus">CAGL0H06919g</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRP7"/>
    <dbReference type="FunCoup" id="Q6FRP7">
        <property type="interactions" value="848"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRP7"/>
    <dbReference type="KEGG" id="cgr:2888767"/>
    <dbReference type="CGD" id="CAL0130361">
        <property type="gene designation" value="CAGL0H06919g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H06919g"/>
    <dbReference type="eggNOG" id="KOG2608">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023061_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FRP7"/>
    <dbReference type="OMA" id="DLPRNLW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273498" description="Endoplasmic oxidoreductin-1" evidence="20">
        <location>
            <begin position="19"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="92"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="141"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0130361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG60030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="71940" checksum="E1632647CEA3E876" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRU1</accession>
    <name>Q6FRU1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0H05907g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRU1"/>
    <dbReference type="FunCoup" id="Q6FRU1">
        <property type="interactions" value="674"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRU1"/>
    <dbReference type="KEGG" id="cgr:2888785"/>
    <dbReference type="CGD" id="CAL0130350">
        <property type="gene designation" value="CAGL0H05907g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05907g"/>
    <dbReference type="eggNOG" id="KOG2411">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FRU1"/>
    <dbReference type="OMA" id="LCGWVDR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070146">
        <property type="term" value="P:mitochondrial aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04321">
        <property type="entry name" value="ScAspRS_mt_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001750">
        <property type="entry name" value="PRK00476.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="169"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0130350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="659" mass="76194" checksum="CE88B81C27C062DD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2018-02-28" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRZ8</accession>
    <name>AP1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">bZip transcription factor GAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">AP1</name>
        <name type="ordered locus">CAGL0H04631g</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2007" name="Gene" volume="386" first="63" last="72">
            <title>The bZip transcription factor Cgap1p is involved in multidrug resistance and required for activation of multidrug transporter gene CgFLR1 in Candida glabrata.</title>
            <authorList>
                <person name="Chen K.H."/>
                <person name="Miyazaki T."/>
                <person name="Tsai H.F."/>
                <person name="Bennett J.E."/>
            </authorList>
            <dbReference type="PubMed" id="17046176"/>
            <dbReference type="DOI" id="10.1016/j.gene.2006.08.010"/>
        </citation>
        <scope>DISRUPTION PHENOTYPE</scope>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that plays a critical role in response to various stresses and reduces the stress through transcriptional activation of its target genes including multidrug transporter FLR1 (PubMed:17046176).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains two cysteine rich domains (CRD), referred to as the N- and C-terminal CRD's, n-CRD and c-CRD, respectively (By similarity). A nuclear export signal is embedded in the c-CRD, with which the nuclear export protein CRM1/exportin 1 interacts only in the absence of disulfide bonds (or otherwise oxidized cysteines) within the c-CRD or between the c-CRD and the n-CRD.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Leads to decreased resistance to hydrogen peroxide, 4-nitroquinoline-N-oxide (4-NQO), benomyl, and cadmium chloride (PubMed:17046176).</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRZ8"/>
    <dbReference type="SMR" id="Q6FRZ8"/>
    <dbReference type="FunCoup" id="Q6FRZ8">
        <property type="interactions" value="4239"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRZ8"/>
    <dbReference type="EnsemblFungi" id="CAGL0H04631g-T">
        <property type="protein sequence ID" value="CAGL0H04631g-T-p1"/>
        <property type="gene ID" value="CAGL0H04631g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888604"/>
    <dbReference type="CGD" id="CAL0130344">
        <property type="gene designation" value="AP1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_H04631g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04631g"/>
    <dbReference type="eggNOG" id="ENOG502RPD7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032750_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRZ8"/>
    <dbReference type="OMA" id="VSTFCAK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900101">
        <property type="term" value="P:regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000304">
        <property type="term" value="P:response to singlet oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.100:FF:000002">
        <property type="entry name" value="AP-1-like transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000067">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013910">
        <property type="entry name" value="TF_PAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08601">
        <property type="entry name" value="PAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000443418" description="bZip transcription factor GAP1">
        <location>
            <begin position="1"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="bZIP" evidence="2">
        <location>
            <begin position="25"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Basic motif" evidence="2">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine-zipper" evidence="2">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="164"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Transcription activation 1" evidence="1">
        <location>
            <begin position="189"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="n-CRD" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Transcription activation 2" evidence="1">
        <location>
            <begin position="376"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="c-CRD" evidence="1">
        <location>
            <begin position="536"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear export signal" evidence="1">
        <location>
            <begin position="552"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P19880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17046176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="17046176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="588" mass="64609" checksum="A3907213D0FF57B4" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS52</accession>
    <name>MPS2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Monopolar spindle protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MPS2</name>
        <name type="ordered locus">CAGL0H03421g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MPS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446942.1">
        <property type="nucleotide sequence ID" value="XM_446942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS52"/>
    <dbReference type="SMR" id="Q6FS52"/>
    <dbReference type="FunCoup" id="Q6FS52">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS52"/>
    <dbReference type="EnsemblFungi" id="CAGL0H03421g-T">
        <property type="protein sequence ID" value="CAGL0H03421g-T-p1"/>
        <property type="gene ID" value="CAGL0H03421g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888827"/>
    <dbReference type="KEGG" id="cgr:2888827"/>
    <dbReference type="CGD" id="CAL0131886">
        <property type="gene designation" value="CAGL0H03421g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03421g"/>
    <dbReference type="eggNOG" id="ENOG502RYE7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069890_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS52"/>
    <dbReference type="OMA" id="FIYAKDF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071988">
        <property type="term" value="P:protein localization to spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031433">
        <property type="entry name" value="Mps2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17060">
        <property type="entry name" value="MPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000409156" description="Monopolar spindle protein 2">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="165"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="356" mass="41680" checksum="2D3619F8FA37EFB6" modified="2004-07-19" version="1">MSEVDVPELLFERVWLQVDRDRDGFIYAKQMPSFITQCEQVIKDTVNTNKTDFHMTRFKNRLKLPLLPKLHMDLIDAFAKETPYYKIYKESFSDMLNKLTGNNFSTVINKIFEDCDGFPASFISALEVKADVKSSPRSKADSLGSPIKVDLLRNLKPQEEPETPRRINRKYKSLELQLESMKRELEDKEKTIMNNERNLTELRSTISKLKEKYDLLSEEYEQRHIHGGNNGTAIKHDVVIGELKSRLQEQNRLIRILQEQIQFDPQLKRETRVHDNKSKNNTFNGAIAYVIPFLLFIFVIRSLITKEDIGDATMALPWWERNNLASRLAWYFRDVFSNDSAKFLESDAYDKVFGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS59</accession>
    <name>Q6FS59_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">CAGL0H03267g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS59"/>
    <dbReference type="FunCoup" id="Q6FS59">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS59"/>
    <dbReference type="KEGG" id="cgr:2888823"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016358_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS59"/>
    <dbReference type="OMA" id="NKITEMH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051186">
        <property type="entry name" value="RRM_HNRPC/RALY_subfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13968:SF26">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="330"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="402"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="631"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="707"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="731"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG59868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="775" mass="86969" checksum="EB7BDDA25894EE89" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSD0</accession>
    <name>Q6FSD0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0H01507g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSD0"/>
    <dbReference type="FunCoup" id="Q6FSD0">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888489"/>
    <dbReference type="CGD" id="CAL0130024">
        <property type="gene designation" value="CAGL0H01507g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01507g"/>
    <dbReference type="eggNOG" id="ENOG502QWTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017671_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSD0"/>
    <dbReference type="OMA" id="NYCWRHL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033262">
        <property type="term" value="P:regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF21">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX PROTEIN RSC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0130024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="794" mass="92082" checksum="AEE0044E420A52F8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSE7</accession>
    <name>Q6FSE7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="10">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0H01089g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="10"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSE7"/>
    <dbReference type="FunCoup" id="Q6FSE7">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSE7"/>
    <dbReference type="KEGG" id="cgr:2888626"/>
    <dbReference type="CGD" id="CAL0131694">
        <property type="gene designation" value="CAGL0H01089g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01089g"/>
    <dbReference type="eggNOG" id="KOG2951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FSE7"/>
    <dbReference type="OMA" id="GEAPVWI"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071545">
        <property type="term" value="P:inositol phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000013">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000012">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0452">Lithium</keyword>
    <keyword evidence="8 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0131694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="295" mass="32903" checksum="1E1F276A74341397" modified="2004-07-19" version="1">MAKKLTGEELRKIEQHLIEFLKTDIGPILKNASGTKFDSYDEKVNDVDLVTVVDKKVETLIRKFAEENYPEIKFIGEESLSKDERFDLEDPTFIVDPIDGTTNFIHGFPFSCTSIGVAQGGKPVIGCVYNPHLNQLFHASLGNGAYLNDEPINIEKRTLSLKKSIIGLEGGSEREDGKGTNFTKKFDTYRKLLSDRGAFIHGFRSLGSAAMNICYVSIGYMDAYWEGGCWAWDVCAGWCILNEAGGKIVGGNPGQWNIPINNRSYLAVRGGLVDDDEQEKFIQDFWGFVEGALKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSG2</accession>
    <name>Q6FSG2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0H00759g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446832.1">
        <property type="nucleotide sequence ID" value="XM_446832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSG2"/>
    <dbReference type="STRING" id="284593.Q6FSG2"/>
    <dbReference type="KEGG" id="cgr:2888558"/>
    <dbReference type="CGD" id="CAL0131612">
        <property type="gene designation" value="CAGL0H00759g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H00759g"/>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001103_12_5_1"/>
    <dbReference type="InParanoid" id="Q6FSG2"/>
    <dbReference type="OMA" id="HHDIPKS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001975">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="109"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="308"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="693"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0131612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG59763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="718" mass="81875" checksum="A33FA1F260E0FA29" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSR2</accession>
    <name>Q6FSR2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA topoisomerase</fullName>
            <ecNumber evidence="6">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0G08470g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSR2"/>
    <dbReference type="FunCoup" id="Q6FSR2">
        <property type="interactions" value="997"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSR2"/>
    <dbReference type="KEGG" id="cgr:2888121"/>
    <dbReference type="CGD" id="CAL0130432">
        <property type="gene designation" value="CAGL0G08470g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G08470g"/>
    <dbReference type="eggNOG" id="KOG1956">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FSR2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140226">
        <property type="term" value="F:RNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000018">
        <property type="term" value="P:regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="7">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="8">
        <location>
            <begin position="171"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0130432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="650" mass="74510" checksum="0A9B12C1162D4BF1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSU0</accession>
    <name>MED18_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SRB5</name>
        <name type="synonym">MED18</name>
        <name type="ordered locus">CAGL0G07865g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446704.1">
        <property type="nucleotide sequence ID" value="XM_446704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSU0"/>
    <dbReference type="SMR" id="Q6FSU0"/>
    <dbReference type="FunCoup" id="Q6FSU0">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSU0"/>
    <dbReference type="EnsemblFungi" id="CAGL0G07865g-T">
        <property type="protein sequence ID" value="CAGL0G07865g-T-p1"/>
        <property type="gene ID" value="CAGL0G07865g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888381"/>
    <dbReference type="KEGG" id="cgr:2888381"/>
    <dbReference type="CGD" id="CAL0130037">
        <property type="gene designation" value="CAGL0G07865g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G07865g"/>
    <dbReference type="eggNOG" id="ENOG502RXWG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058255_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FSU0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001113">
        <property type="term" value="P:transcription open complex formation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000304758" description="Mediator of RNA polymerase II transcription subunit 18">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="266" mass="29887" checksum="40DD899F9F150899" modified="2004-07-19" version="1">MVQRLSLMATIADDDFPLFKTSINILTGSPAVVYANLMVVWKPNPNYEVDNLNSKNELVEPTRMTTATSIPLELILNDPVSKNNGVDSDEILNTMKEQEFPIKQEQLFDMINNPSNNTINWTLTTADIPAAGSNRKVSMQAIQEATIVHQAGNNPTLANVMAELGYSFDYMYVTVGVRFVHKRDVIIHCHKVWDIAEDNIIQVTKGGYVVHTFVTVNRATDIERLNLAEANLLSLQRDLSGYLDFKVPDRKSMDSRTNLTQKDITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSY2</accession>
    <name>Q6FSY2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BUB1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G06930g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSY2"/>
    <dbReference type="FunCoup" id="Q6FSY2">
        <property type="interactions" value="785"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSY2"/>
    <dbReference type="KEGG" id="cgr:2888430"/>
    <dbReference type="CGD" id="CAL0130655">
        <property type="gene designation" value="CAGL0G06930g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G06930g"/>
    <dbReference type="eggNOG" id="KOG1166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041820_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSY2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032837">
        <property type="term" value="P:distributive segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902499">
        <property type="term" value="P:positive regulation of protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="2">
        <location>
            <begin position="49"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0130655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="380" mass="44621" checksum="3F403390CA12DD7B" modified="2004-07-19" version="1">MPAQKVTRFEDIEVEKENIAPLRHGRSAHRLVSALSQNDDEIKRIRASFESSLLVKIEDHDDPLVLYLDYIDWINHAFPQGGSSRSSGMLDVIERCITYFKDSERYRDDERYVKIWLWYMELFSDKYKSDCKDLFIFMLRNRIGSKVPLMYEELSSLLYELKEYKYAISVINLGLKECKYGNKSLVDKRQLLLEKLGDDAKVIDDSVEMLDGAERVILGKKQSELREKAKSNKTSDRETKMSSSIYTDSQDPEVHDEPLSCLRNWDIFEILHSRNKENRILAEPLILNELDRTFSGDQLKGGKKMILFQDNLGRSEPVYKLIKNNSGKLEKIDYNTNLLIYEGREICLEEILTMMKSNTQNNKRRREYDDSKNLHIKKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT80</accession>
    <name>Q6FT80_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G04697g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT80"/>
    <dbReference type="FunCoup" id="Q6FT80">
        <property type="interactions" value="86"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT80"/>
    <dbReference type="KEGG" id="cgr:2887995"/>
    <dbReference type="CGD" id="CAL0129640">
        <property type="gene designation" value="CAGL0G04697g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04697g"/>
    <dbReference type="eggNOG" id="KOG2063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005205_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FT80"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF28">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="2">
        <location>
            <begin position="76"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="950" mass="111252" checksum="9D4EFC30C2492ED6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTF9</accession>
    <name>Q6FTF9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF2 kinase activator protein MOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G02805g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTF9"/>
    <dbReference type="FunCoup" id="Q6FTF9">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTF9"/>
    <dbReference type="KEGG" id="cgr:2888285"/>
    <dbReference type="CGD" id="CAL0130556">
        <property type="gene designation" value="CAGL0G02805g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02805g"/>
    <dbReference type="eggNOG" id="KOG0440">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038321_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FTF9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071958">
        <property type="term" value="C:new mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071957">
        <property type="term" value="C:old mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034973">
        <property type="term" value="C:Sid2-Mob1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903473">
        <property type="term" value="P:positive regulation of mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031031">
        <property type="term" value="P:positive regulation of septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0130556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33578" checksum="128AEBAE94AC3F59" modified="2004-07-19" version="1">MSFLQNFHLSPGQTIRSTRGFKWNSGSNQNGMADSQDTSSGVKSDRMLFNNSPLNPSNDNIQILSTPKKQQQTAPVVTDFNYTPSHQKPFIQPQAGTTVTSHQDIKEIVEMTLGSEGVLNQAVKLPRGENENEWMAVHCVDFYNQINMLYGTITEFCSPQTCPRMIATNEYEYLWAFQRGQPPVSVPAPKYVEALMKWCQDQFDNESIFPAKTSGQFPDKFIERHVIPILRRLFRVYAHIYCHHFNEILELNLQTVLNTSFRHFCLFTQEFQLLKASDFGPLLELVTELRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTL6</accession>
    <name>Q6FTL6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NCE103</name>
        <name evidence="9 10" type="ordered locus">CAGL0G01540g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446428.1">
        <property type="nucleotide sequence ID" value="XM_446428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTL6"/>
    <dbReference type="FunCoup" id="Q6FTL6">
        <property type="interactions" value="123"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTL6"/>
    <dbReference type="BindingDB" id="Q6FTL6"/>
    <dbReference type="ChEMBL" id="CHEMBL6185"/>
    <dbReference type="DrugCentral" id="Q6FTL6"/>
    <dbReference type="GeneID" id="2888184"/>
    <dbReference type="KEGG" id="cgr:2888184"/>
    <dbReference type="CGD" id="CAL0130741">
        <property type="gene designation" value="NCE103"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01540g"/>
    <dbReference type="eggNOG" id="KOG1578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FTL6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00883">
        <property type="entry name" value="beta_CA_cladeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1050.10:FF:000010">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00705">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0130741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="219" mass="24716" checksum="3EC935B3CFD99C30" modified="2004-07-19" version="1">MTKDTIFTLTGKCALDNILDANRQWAQAMHRSQPQLFPTNGQGQDPHTLFIGCSDSRYNEDCLGVLPGEIFTLKTVANICHTDDHSLLATLEFAILNLKVNRIILCGHTDCGGIKTCLLGRESIKESCPHLYEHLDDIEDLVESHESELNQLDNICSKSKLMSHRNVERQLQRLLQIPVVQDALRNSNQDHEFNIFGLVYNVDSGLVDVVREVYGNQQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTM0</accession>
    <name>LKHA4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Leucine aminopeptidase 2</fullName>
            <ecNumber>3.4.11.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Epoxide hydrolase</fullName>
            <ecNumber>3.3.2.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName>Leukotriene A-4 hydrolase homolog</fullName>
            <shortName>LTA-4 hydrolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">CAGL0G01430g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-"/>
    <dbReference type="EC" id="3.3.2.10"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTM0"/>
    <dbReference type="SMR" id="Q6FTM0"/>
    <dbReference type="FunCoup" id="Q6FTM0">
        <property type="interactions" value="1102"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTM0"/>
    <dbReference type="MEROPS" id="M01.034"/>
    <dbReference type="EnsemblFungi" id="CAGL0G01430g-T">
        <property type="protein sequence ID" value="CAGL0G01430g-T-p1"/>
        <property type="gene ID" value="CAGL0G01430g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888012"/>
    <dbReference type="CGD" id="CAL0129700">
        <property type="gene designation" value="CAGL0G01430g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01430g"/>
    <dbReference type="eggNOG" id="KOG1047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014505_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FTM0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061957">
        <property type="term" value="C:NVT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120113">
        <property type="term" value="P:cytoplasm to vacuole targeting by the NVT pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00142">
        <property type="entry name" value="ZINC_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000324925" description="Leucine aminopeptidase 2">
        <location>
            <begin position="1"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="293"/>
            <end position="298"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P09960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q10740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="652" mass="74823" checksum="4AD4BB847DEF880B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTN0</accession>
    <name>Q6FTN0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NIT3</name>
        <name evidence="3 4" type="ordered locus">CAGL0G01210g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446414.1">
        <property type="nucleotide sequence ID" value="XM_446414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTN0"/>
    <dbReference type="FunCoup" id="Q6FTN0">
        <property type="interactions" value="697"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTN0"/>
    <dbReference type="GeneID" id="2888114"/>
    <dbReference type="KEGG" id="cgr:2888114"/>
    <dbReference type="CGD" id="CAL0129550">
        <property type="gene designation" value="NIT3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G01210g"/>
    <dbReference type="eggNOG" id="KOG0806">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FTN0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="288" mass="31853" checksum="DE59AA4394F783D9" modified="2004-07-19" version="1">MSYILKSKVKVALIQLVGSTPDKLANLKHAKALIDNAMQREPETKIVVLPECFNSPYDVTQFAKYSEVIEDPEAPSVNILKEIAKTHAITLIGGSIPERDPANDNIYNTCLIINEEGSIIAKHRKLHLFDIDIPNKITFKESITLTGGDKVTMVDTKYGKIGVGICYDLRFPEMAMIAARKGAFAMIYPGAFNTVTGPLHWQLLARARSVDNQIYTLLCSPARVPGSPYQAWGHSLCSDPSGKILCEADINEETLFIDLDPEVIETTRGGIPITTQRRFDVYPDVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTT3</accession>
    <name>Q6FTT3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0F09053g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTT3"/>
    <dbReference type="FunCoup" id="Q6FTT3">
        <property type="interactions" value="545"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTT3"/>
    <dbReference type="KEGG" id="cgr:2887848"/>
    <dbReference type="CGD" id="CAL0131196">
        <property type="gene designation" value="CAGL0F09053g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F09053g"/>
    <dbReference type="eggNOG" id="KOG2429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_5_3_1"/>
    <dbReference type="InParanoid" id="Q6FTT3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106055">
        <property type="term" value="C:mannosyl-oligosaccharide 1,2-alpha-mannosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900103">
        <property type="term" value="P:positive regulation of endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097466">
        <property type="term" value="P:ubiquitin-dependent glycoprotein ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273580" description="alpha-1,2-Mannosidase" evidence="9">
        <location>
            <begin position="17"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="521"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0131196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="809" mass="94129" checksum="BF86EFD8E426E548" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTX8</accession>
    <name>Q6FTX8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kelch repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0F07997g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTX8"/>
    <dbReference type="STRING" id="284593.Q6FTX8"/>
    <dbReference type="KEGG" id="cgr:2887843"/>
    <dbReference type="CGD" id="CAL0131398">
        <property type="gene designation" value="CAGL0F07997g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07997g"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005472_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTX8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="553"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="820"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="678"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="572"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="830"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0131398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="936" mass="106010" checksum="D4B7F3DB8D8B7429" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU04</accession>
    <name>Q6FU04_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0F07425g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU04"/>
    <dbReference type="FunCoup" id="Q6FU04">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU04"/>
    <dbReference type="KEGG" id="cgr:2887976"/>
    <dbReference type="CGD" id="CAL0131168">
        <property type="gene designation" value="CAGL0F07425g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07425g"/>
    <dbReference type="eggNOG" id="ENOG502RV3A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030292_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU04"/>
    <dbReference type="OMA" id="EGWARMI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14373">
        <property type="entry name" value="CUE_Cue3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041808">
        <property type="entry name" value="Cue3_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="311"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="614" mass="71993" checksum="05CD95D32DC5493D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUA7</accession>
    <name>Q6FUA7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="12">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SMD2</name>
        <name evidence="14 15" type="ordered locus">CAGL0F04961g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446187.1">
        <property type="nucleotide sequence ID" value="XM_446187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUA7"/>
    <dbReference type="FunCoup" id="Q6FUA7">
        <property type="interactions" value="1295"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUA7"/>
    <dbReference type="GeneID" id="2887871"/>
    <dbReference type="KEGG" id="cgr:2887871"/>
    <dbReference type="CGD" id="CAL0131160">
        <property type="gene designation" value="SMD2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F04961g"/>
    <dbReference type="eggNOG" id="KOG3459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FUA7"/>
    <dbReference type="OMA" id="DVKEMWT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036261">
        <property type="term" value="P:7-methylguanosine cap hypermethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000018">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="31"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0131160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG59111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="110" mass="12868" checksum="51113ECC45BF0A42" modified="2004-07-19" version="1">MSEAIISRPKSELSKEELEQLEEFEFKHGPMSLINDAMITRNPVIISLRNNHKLIARVKAFDRHCNLVLENVKELWTEKKNKQTINRERFISKLFLRGDSVIVILKAPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUH6</accession>
    <name>Q6FUH6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0F03421g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUH6"/>
    <dbReference type="FunCoup" id="Q6FUH6">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUH6"/>
    <dbReference type="KEGG" id="cgr:2887875"/>
    <dbReference type="CGD" id="CAL0129238">
        <property type="gene designation" value="CAGL0F03421g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03421g"/>
    <dbReference type="eggNOG" id="ENOG502RC08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011999_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUH6"/>
    <dbReference type="OMA" id="INNTMTW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="756"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="817" mass="93207" checksum="C6B3C4047A9220DD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUI2</accession>
    <name>Q6FUI2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0F03267g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446112.1">
        <property type="nucleotide sequence ID" value="XM_446112.1"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887625"/>
    <dbReference type="CGD" id="CAL0129268">
        <property type="gene designation" value="CAGL0F03267g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03267g"/>
    <dbReference type="eggNOG" id="KOG1032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002908_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUI2"/>
    <dbReference type="OMA" id="QETHAGD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1191"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="9">
        <location>
            <begin position="749"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="9">
        <location>
            <begin position="962"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="666"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="323"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="696"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1158"/>
            <end position="1169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0129268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG59036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1330" mass="146903" checksum="81EB337A4C733116" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-06-21" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV07</accession>
    <name>AURK_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Aurora kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Spindle assembly checkpoint kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">IPL1</name>
        <name type="ordered locus">CAGL0E05720g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. Has a role in error-correction of aberrent kinetochore-microtubule attachments to ensure that sister kinetochores become bioriented and connect to opposite poles by promoting spindle assembly checkpoint signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
        <text evidence="1">Associates with the mitotic spindle and on elongated and disassembling spindles. Also associated with the kinetochore (By similarity).</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445937.1">
        <property type="nucleotide sequence ID" value="XM_445937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV07"/>
    <dbReference type="SMR" id="Q6FV07"/>
    <dbReference type="FunCoup" id="Q6FV07">
        <property type="interactions" value="1180"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV07"/>
    <dbReference type="EnsemblFungi" id="CAGL0E05720g-T">
        <property type="protein sequence ID" value="CAGL0E05720g-T-p1"/>
        <property type="gene ID" value="CAGL0E05720g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887534"/>
    <dbReference type="KEGG" id="cgr:2887534"/>
    <dbReference type="CGD" id="CAL0128618">
        <property type="gene designation" value="CAGL0E05720g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05720g"/>
    <dbReference type="eggNOG" id="KOG0580">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_6_1"/>
    <dbReference type="InParanoid" id="Q6FV07"/>
    <dbReference type="OMA" id="ESRFPEW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045143">
        <property type="term" value="P:homologous chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044779">
        <property type="term" value="P:meiotic spindle checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044774">
        <property type="term" value="P:mitotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901925">
        <property type="term" value="P:negative regulation of protein import into nucleus during spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0137">Centromere</keyword>
    <keyword id="KW-0158">Chromosome</keyword>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0995">Kinetochore</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000086026" description="Aurora kinase">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="100"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 5">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="106"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="D6W3G1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P38991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="358" mass="40992" checksum="251500844A6CF5C6" modified="2004-07-19" version="1">MENKATLARNIGEKRVSPRSKVNGTGKSWRISYSPQRMDGVSSGRNVSKIPSPVRERLFLKNQERKPLGVSPLSNLSPNSLGRNSLEKSTYNNKLSLKDFEVGRKLGKGKFGKVYCVRHKKSGFICALKAIEKNEILQFNLLKQLKREVDIQLGMDHPNIIKLYAHFHDEKRVYLLMEHSINGELYKSLKNNGPFNDVLASHYIYQIADALHYMHKKRIIHRDVKPENVLIGFDNVVKLADFGWSILNPEGSKRKTLCGTIDYLSPEMITPREYDEQVDVWALGVLAYELVVGVPPFEENSKELTYKRILKCDLNFPESISKDAKDLISKLLVTDTTQRLSLTGVKTHPWILKNKPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV77</accession>
    <name>Q6FV77_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">N-alpha-acetyltransferase, 35 NatC auxiliary subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0E04136g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV77"/>
    <dbReference type="FunCoup" id="Q6FV77">
        <property type="interactions" value="657"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV77"/>
    <dbReference type="KEGG" id="cgr:2887313"/>
    <dbReference type="CGD" id="CAL0128970">
        <property type="gene designation" value="CAGL0E04136g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04136g"/>
    <dbReference type="eggNOG" id="KOG2343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022669_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FV77"/>
    <dbReference type="OMA" id="QMEWIVQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="39"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="332"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0128970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="776" mass="88757" checksum="DE0E4AC4BA35714F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVF0</accession>
    <name>Q6FVF0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chitin synthase 3 complex protein CSI2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0E02409g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVF0"/>
    <dbReference type="FunCoup" id="Q6FVF0">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887538"/>
    <dbReference type="CGD" id="CAL0128888">
        <property type="gene designation" value="CAGL0E02409g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02409g"/>
    <dbReference type="eggNOG" id="ENOG502RZE8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066467_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVF0"/>
    <dbReference type="OMA" id="QSARSEY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274890" description="Chitin synthase 3 complex protein CSI2" evidence="3">
        <location>
            <begin position="24"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0128888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38495" checksum="F6BAC629F9E2A32F" modified="2004-07-19" version="1">MKSSQVTQIFLLIASFLVSSVDAVVVATQPSHHLHMRGLPKLVTTSETPTPTSTEEPSTSSTSDNSESSETEGSSTEITSTSESSIYSESVTASSTTSDTDSETSSTTSYTSYTPSTTSVSVGPIYIPSAQNNKYVYHATHPSGTVFTAFGSCLAFIALVLVLVWIALTLRSWKNARKEYQIRERENKYQLDPYYFQNGDKDDYSSSDSDVASDISEKILKKKASRMSLYSLGGGSAFNLLSSEKLDTKPPAPPSNNPRLSMFISPTEILKNEGNTWSTDSSAFNSLTSTPREQSVANIIVPQNGLNKLGDPPFTGKNLSNMDISSTPGVAIPKPNGNQKRGRPPSAHLDDLLDGIQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVF9</accession>
    <name>ERFD_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">ERF4</name>
        <name type="ordered locus">CAGL0E02189g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58704.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVF9"/>
    <dbReference type="SMR" id="Q6FVF9"/>
    <dbReference type="FunCoup" id="Q6FVF9">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVF9"/>
    <dbReference type="KEGG" id="cgr:2887281"/>
    <dbReference type="eggNOG" id="ENOG502S30T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087349_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVF9"/>
    <dbReference type="OMA" id="CITHFPN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000213983" description="Ras modification protein ERF4">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P41912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="265" mass="30455" checksum="3E1C3F20DBF03C8E" modified="2009-02-10" version="2">MYTDLEDNENRFYTNSDVILEEGTLGSSLGRSSRRTHEKGEDVQDPVFFNVHEVTESYFADITNPTVFRDHDEDHSLCVTHFMNVYASQDSRLFEETRVVRIPRRFDMGNRWYPMFSDLLPGSEPGAILHDTDGLQFVPRGITQDGNVYGYSSVSPLSLYLTQQHFQEIVTTINDILLATYSTYGFYNILNIILEVFTLGLWSYVCKRINYALSIDPMKRLDVYVRELNASPAFVEAQIKLINPRDSGFLSLDFQIPKPKSISTQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVL4</accession>
    <name>TRM82_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Transfer RNA methyltransferase 82</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">TRM82</name>
        <name type="ordered locus">CAGL0E00979g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with the catalytic subunit TRM8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445730.1">
        <property type="nucleotide sequence ID" value="XM_445730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVL4"/>
    <dbReference type="SMR" id="Q6FVL4"/>
    <dbReference type="FunCoup" id="Q6FVL4">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVL4"/>
    <dbReference type="EnsemblFungi" id="CAGL0E00979g-T">
        <property type="protein sequence ID" value="CAGL0E00979g-T-p1"/>
        <property type="gene ID" value="CAGL0E00979g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887360"/>
    <dbReference type="KEGG" id="cgr:2887360"/>
    <dbReference type="CGD" id="CAL0128862">
        <property type="gene designation" value="CAGL0E00979g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00979g"/>
    <dbReference type="eggNOG" id="KOG3914">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022082_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVL4"/>
    <dbReference type="OMA" id="VKHWLFG"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000370517" description="tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="216"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <sequence length="421" mass="47568" checksum="892A54E5EB1E9E77" modified="2004-07-19" version="1">MFVHPLNVAISDSQNKYQYVVCKHTISVFAGEKLVGYWVDTDQRDSHNSYKKLKSNAGDAKPKGSQGIGAPAVYSYIRNLRLTSDEGKLIACVDSDKSVVIFKIDTSAEDPEKFLQVMKRQQFPKRPNALALADEDTTIIVADKFGDVYKLKIDEEPIRKIDDQSEPILGHVSMLTDVAVAKDANNKSYIITTDRDEHIKISHYPQTFIVDKWLFGHKEFVSSVDLPKWQTKFLFSAGGDKEIFAWNWQSGELLSQYSFEDAVKPFINDQHLAPARFQNEENNVIEYAVASIKSCGQQPYVAFFVEATPVLFILHCNTETGELSLAQQVEFKHNVVSISSNGKSEYLVTFDNRDENAEQLIAFLTYSGDSNKPFSVDENLNKLNSSWISTFKQKDELLADADSVYPLYNIASLKKHGEHFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-20" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVQ3</accession>
    <name>COX19_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Cytochrome c oxidase assembly protein COX19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">COX19</name>
        <name type="ordered locus">CAGL0D06578g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Assembly factor for cytochrome c oxidase (respiratory chain complex IV, CIV). Acts as a COX11 chaperone that supports COX11 copper coordination. Cannot compensate for the absence of COX11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445691.1">
        <property type="nucleotide sequence ID" value="XM_445691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVQ3"/>
    <dbReference type="SMR" id="Q6FVQ3"/>
    <dbReference type="FunCoup" id="Q6FVQ3">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVQ3"/>
    <dbReference type="EnsemblFungi" id="CAGL0D06578g-T">
        <property type="protein sequence ID" value="CAGL0D06578g-T-p1"/>
        <property type="gene ID" value="CAGL0D06578g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887132"/>
    <dbReference type="KEGG" id="cgr:2887132"/>
    <dbReference type="CGD" id="CAL0128057">
        <property type="gene designation" value="CAGL0D06578g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_D06578g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D06578g"/>
    <dbReference type="eggNOG" id="KOG3477">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141947_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FVQ3"/>
    <dbReference type="OMA" id="GTNDEAC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000122286" description="Cytochrome c oxidase assembly protein COX19">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="CHCH" evidence="2">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx9C motif 1" evidence="2">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx9C motif 2" evidence="2">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q3E731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="86" mass="9734" checksum="173B43D579F4B0BF" modified="2004-07-19" version="1">MSSGNPGGALRALSPTPPERGSFPLDHDGECAEYMQKYLQCMRLAANENAHNCRLLAKDYLKCRMDHQLMDKDEWKNLGLPPDDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVV9</accession>
    <name>Q6FVV9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0D05192g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVV9"/>
    <dbReference type="STRING" id="284593.Q6FVV9"/>
    <dbReference type="KEGG" id="cgr:2887044"/>
    <dbReference type="CGD" id="CAL0128153">
        <property type="gene designation" value="CAGL0D05192g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05192g"/>
    <dbReference type="eggNOG" id="KOG4763">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115913_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FVV9"/>
    <dbReference type="OMA" id="NTCNDRV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="52"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0128153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG58546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="123" mass="14495" checksum="5A6BA62A27574477" modified="2004-07-19" version="1">MISSITDLLEELKETIVPVVAEAAEEDPVEDEEEEDEDEDEDEDEDEEEGVDQLDALREECKNTEEGKHLVHHYMECVERVTKQQEDPEYENLDYKEDCVEEFFHLQHYLDSCAAPRLFDKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWB7</accession>
    <name>Q6FWB7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone deacetylase</fullName>
            <ecNumber evidence="3">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0D01430g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWB7"/>
    <dbReference type="FunCoup" id="Q6FWB7">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWB7"/>
    <dbReference type="KEGG" id="cgr:2887160"/>
    <dbReference type="CGD" id="CAL0128381">
        <property type="gene designation" value="CAGL0D01430g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01430g"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_7_8_1"/>
    <dbReference type="InParanoid" id="Q6FWB7"/>
    <dbReference type="OMA" id="MSRFYTY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF14">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0128381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="445" mass="50739" checksum="E9220B01226B0513" modified="2004-07-19" version="1">MVQLVISASQFQSQVVDLLPCNKRQKSQLIYSMLESYGLLECFDHIIDVPSCQRKDLEKFHSKDYLNVILDEQLNWNPQIDGNEDQLMELRKAWNDITTSNEASKPDFKTYSELLHYYRDHIEVSEHNKKRTALEAELSDVESGDEVTRRSTLAKFNLLDDCPIFPYLPLYCYVSTGATLSLAQYILEGSERTIAINWDGGRHHSMKTKASGFCYINDIALLIMTLRRGGVDRISYVDFDLHHGDGVEKAFKYSKQVQTISLHMYETGFFPCSGSLEDNSSGKSIVNIPLLHGLDDSTLQDIAKRIIVPSISKHQPNVIVIQCGGDGLKGDKYSEWQLSIKGLTSTITSLIEQFNCHIVLLGGGGYNNLLMSRFYTYLTWSICHQYASEYSTPIDDLIQDHCYSDLYSPEQFKFWYYDQETSGGSLKNYNTTAYIEDLIKNIPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWG1</accession>
    <name>Q6FWG1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0D00462g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWG1"/>
    <dbReference type="FunCoup" id="Q6FWG1">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWG1"/>
    <dbReference type="KEGG" id="cgr:2887043"/>
    <dbReference type="CGD" id="CAL0127951">
        <property type="gene designation" value="CAGL0D00462g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00462g"/>
    <dbReference type="eggNOG" id="ENOG502QX5C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_387791_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWG1"/>
    <dbReference type="OMA" id="SDSPCWR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005933">
        <property type="term" value="C:cellular bud"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031495">
        <property type="term" value="P:negative regulation of mating type switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900461">
        <property type="term" value="P:positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="3">
        <location>
            <begin position="623"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="311"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0127951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="712" mass="78317" checksum="2A7B0BAA599D41F7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWV4</accession>
    <name>Q6FWV4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0C02607g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWV4"/>
    <dbReference type="FunCoup" id="Q6FWV4">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWV4"/>
    <dbReference type="KEGG" id="cgr:2886733"/>
    <dbReference type="CGD" id="CAL0127546">
        <property type="gene designation" value="CAGL0C02607g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02607g"/>
    <dbReference type="eggNOG" id="KOG1302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398604_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWV4"/>
    <dbReference type="OMA" id="AYCGVVP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033263">
        <property type="term" value="C:CORVET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035542">
        <property type="term" value="P:regulation of SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051469">
        <property type="term" value="P:vesicle fusion with vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099022">
        <property type="term" value="P:vesicle tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
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        <property type="entry name" value="Sec1-like"/>
    </dbReference>
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        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
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        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="77642" checksum="F7E1B3CD9E3FFC3C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWW2</accession>
    <name>Q6FWW2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Factor interacting with REF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0C02431g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWW2"/>
    <dbReference type="FunCoup" id="Q6FWW2">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886745"/>
    <dbReference type="CGD" id="CAL0127262">
        <property type="gene designation" value="CAGL0C02431g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02431g"/>
    <dbReference type="eggNOG" id="ENOG502RI27">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007020_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWW2"/>
    <dbReference type="OMA" id="EDIWKFH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="929" mass="103945" checksum="A1846EB9E6E12C50" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FX46</accession>
    <name>Q6FX46_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ISWI one complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0C00385g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FX46"/>
    <dbReference type="FunCoup" id="Q6FX46">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FX46"/>
    <dbReference type="KEGG" id="cgr:2886904"/>
    <dbReference type="CGD" id="CAL0127376">
        <property type="gene designation" value="CAGL0C00385g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C00385g"/>
    <dbReference type="eggNOG" id="ENOG502QPXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016629_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FX46"/>
    <dbReference type="OMA" id="WQHWECQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036437">
        <property type="term" value="C:Isw1b complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="853" mass="99529" checksum="F49D8FCC54961B12" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXC1</accession>
    <name>HSV2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>SVP1-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">HSV2</name>
        <name type="ordered locus">CAGL0B02101g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Vesicular and vacuolar.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">May contain a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445061.1">
        <property type="nucleotide sequence ID" value="XM_445061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXC1"/>
    <dbReference type="SMR" id="Q6FXC1"/>
    <dbReference type="FunCoup" id="Q6FXC1">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXC1"/>
    <dbReference type="EnsemblFungi" id="CAGL0B02101g-T">
        <property type="protein sequence ID" value="CAGL0B02101g-T-p1"/>
        <property type="gene ID" value="CAGL0B02101g"/>
    </dbReference>
    <dbReference type="GeneID" id="2886497"/>
    <dbReference type="KEGG" id="cgr:2886497"/>
    <dbReference type="CGD" id="CAL0127752">
        <property type="gene designation" value="CAGL0B02101g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B02101g"/>
    <dbReference type="eggNOG" id="KOG2111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025895_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FXC1"/>
    <dbReference type="OMA" id="GGPQCMC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000051026" description="SVP1-like protein 2">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="218"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="263"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="445" mass="50429" checksum="F11710D94A8256C6" modified="2004-07-19" version="1">MDVREAIQQEAGAETGFASVTFNQDESCFSCANEQGFLVYNTFPLSLKLTKEFKQTPERGAGIGYSQMLYRTNYIALVGGGQRPRYSLNRVVIWDDLQQKESFSLKFMSIVRKVVLSRVHLVVALENELFIYSFHSTPKLLCPPIKTAPFGPFDFKVVTIEGKATDQAKVTSLLAYPSAKLTGQLHVADLSKLRSNQNNNQDMALTSESFLPTTIIKAHKAPIRNVRINNQGTMVATASRKGTLIRIFSTHNGILLKEFRRGLDRAEIYDMCFSPLGTRLAVVSDKQTLHVFQIAPMAEGTLNPANPEDHQSSGSNGHIKANTNQVHSLRNIVPTSWKPKYLDSVWSMCKVHLRNPKLRNNVNDLAFNEDRCTIAWCRQNRSHTFKNGNHFNENEENKLVLVWKNSRIWEKYVILEKEAPNSNDGIKGPSPLTEWELVRESWREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXG5</accession>
    <name>Q6FXG5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Transaldolase</fullName>
            <ecNumber evidence="4 10">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TAL1</name>
        <name evidence="11 12" type="ordered locus">CAGL0B03069g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445106.1">
        <property type="nucleotide sequence ID" value="XM_445106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXG5"/>
    <dbReference type="FunCoup" id="Q6FXG5">
        <property type="interactions" value="734"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXG5"/>
    <dbReference type="GeneID" id="2886600"/>
    <dbReference type="KEGG" id="cgr:2886600"/>
    <dbReference type="CGD" id="CAL0127864">
        <property type="gene designation" value="TAL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03069g"/>
    <dbReference type="eggNOG" id="KOG2772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047470_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FXG5"/>
    <dbReference type="OMA" id="FATIKKY"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00492">
        <property type="entry name" value="Transaldolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009001">
        <property type="entry name" value="PRK12346.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0127864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="334" mass="36720" checksum="F7D44B4480FCD398" modified="2004-07-19" version="1">MSEPVQKKQKTNSSLDQLKASGTVVVADTGDFESIAKFQPQDSTTNPSLILAAAKQPAYAKLIDVAVEYGKKHGKTVEEQTEAAVDRLLVEFGKEILKIVPGRVSTEVDARLSFDKEATIAKALQIIKLYEEQGISKSRVLIKIASTWEGIQAARELESKHGIHCNLTLLFNFAQAVACAEANITLISPFVGRIMDYYKAKTGETYTGETDPGVKSVRAIYNYYKKYGYKTIVMGASFRNIDEIKALAGVDYLTISPNLLDQLLNSNDPVPKILDPATAKDEAGEKVTFVDNESAFRFALNDDAMATDKLSDGIRKFSADIITLFDMIEKKVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXK3</accession>
    <name>Q6FXK3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocon Sec61/SecY plug domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0B03245g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXK3"/>
    <dbReference type="FunCoup" id="Q6FXK3">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXK3"/>
    <dbReference type="KEGG" id="cgr:2886676"/>
    <dbReference type="CGD" id="CAL0127690">
        <property type="gene designation" value="CAGL0B03245g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03245g"/>
    <dbReference type="eggNOG" id="KOG1373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FXK3"/>
    <dbReference type="OMA" id="QAYCHIK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071261">
        <property type="term" value="C:Ssh1 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="3">
        <location>
            <begin position="40"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0127690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="491" mass="53487" checksum="0FE9AD5D1CD1EE4B" modified="2004-07-19" version="1">MAIKLIDLARTFLPLLPEVEVPFEKITFDDKVVYTIFSALIYLFAQFPLVGLPKETAPGTQVNDPLYFLRGVFAAEPKTLLEFGIFPNVASALILQLLAGLKVIKVNFKNQKDRELFQTLIKLFALFQYFILANIFIYSGYYGQNLSIVQVGLINLQLCGAGLVTTLISEVVDKGFGFSSGMMVINTVSIATNLVSDTLGISQISVDEDNNTEPQGSLINLIQSFRAKHRSLLEGIISAFNRDYLPNLTTTVIVLGIAAVICYLQSVRMELAIRSTRARGMSNIYPIRLLYVGCLSVLFSYVILFYIHIGAFTLIQLIAKNNIENPICKVLGHYDMVNNLLAVPSFPLSLLTPPRSLLSSITEQPLTLITYTIFMVATGVYFADKWQEISGSSARDVAAEFKEQGITLNGRREQSVAKELNKVIPVAAKTGAAILAAITVCGELLGLKGKAAGIVVGVAGGFSLLELITLDYQQSGGQSALTQVLGAPMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXM8</accession>
    <name>Q6FXM8_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RAS1</name>
        <name evidence="13 14" type="ordered locus">CAGL0B04521g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The S.cerevisiae Ras proteins modulate the activity of the adenylate cyclase catalytic subunit and therefore affect the biosynthesis of cyclic-AMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445167.1">
        <property type="nucleotide sequence ID" value="XM_445167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXM8"/>
    <dbReference type="FunCoup" id="Q6FXM8">
        <property type="interactions" value="636"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXM8"/>
    <dbReference type="GeneID" id="2886566"/>
    <dbReference type="KEGG" id="cgr:2886566"/>
    <dbReference type="CGD" id="CAL0126998">
        <property type="gene designation" value="RAS1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04521g"/>
    <dbReference type="eggNOG" id="KOG0395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_9_0_1"/>
    <dbReference type="InParanoid" id="Q6FXM8"/>
    <dbReference type="OMA" id="APITECQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="181"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="274"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0126998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG58067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="339" mass="37053" checksum="2E28E2909EA6A935" modified="2004-07-19" version="1">MNKPSIREYKLVVVGGGGVGKSALTIQLVHSHFVDEYDPTIEDSYRKQVVIDDKVTILDILDTAGQEEYSAMREQYMRTGEGFLLVYSVTSRTSFEELITYYQQIQRVKDVEYIPVVVVGNKSDLETERQVSFEEGASLAKQLNAPFLETSAKQAINVEDAFYTLVRLVRDDGGKYNKYLEKTQDGNTGAGAKDHSTSNMATSANNYNSQMNNAQSAGMGGEYKGSSNSMNNNSMRNSNGHMEGANNAMDSYNKGTAGNDMYGQDTNMDSSRMNQQSTSAANNMNSSSGANRANNQQNRSSGNTGNDGRQARAQQSSQSENKITENKTKESGGGCCVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY03</accession>
    <name>Q6FY03_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">CAGL0A02134g</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY03"/>
    <dbReference type="FunCoup" id="Q6FY03">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY03"/>
    <dbReference type="KEGG" id="cgr:2886455"/>
    <dbReference type="eggNOG" id="ENOG502QUU7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1035145_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY03"/>
    <dbReference type="OMA" id="IFDAGYW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013952">
        <property type="entry name" value="DUF1776_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08643">
        <property type="entry name" value="DUF1776"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAG57750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="289" mass="33409" checksum="E09FEF2A901BA16A" modified="2004-07-19" version="1">MAIPAVSIALYWGSTQLKVRPILSTTENQCILVFGDMRDPIIRGQVMDLYRRGFTLFVCLENAGTYKTHNDEDDFLNYIDPKSTSDWAKFSEFFRKFPTNTLSAILLIPKLSYHPTGQVTLEQLENELHSNVLIYYSTLVAISPHLPQNSNSNRIPTLIYNPSLSVNMKNVEHPVEWLISGLMTTIFEELKHSHIFDPYMINVGLFQLGGQLSNYKYLNVKGSNIYNDLYWPIYCFIKMKGGNTFQKLHVAICSLFGLKRTFYLGKFSYLFTLPFTSKLYKLLNEWYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY32</accession>
    <name>Q6FY32_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">YPS7</name>
        <name evidence="4 5" type="ordered locus">CAGL0A02431g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444870.1">
        <property type="nucleotide sequence ID" value="XM_444870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY32"/>
    <dbReference type="SMR" id="Q6FY32"/>
    <dbReference type="FunCoup" id="Q6FY32">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY32"/>
    <dbReference type="MEROPS" id="A01.097"/>
    <dbReference type="GeneID" id="2886415"/>
    <dbReference type="KEGG" id="cgr:2886415"/>
    <dbReference type="CGD" id="CAL0126641">
        <property type="gene designation" value="YPS7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02431g"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023427_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY32"/>
    <dbReference type="OMA" id="KNIYMAM"/>
    <dbReference type="PHI-base" id="PHI:7931"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF65">
        <property type="entry name" value="ASPARTIC-TYPE ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273532" description="Peptidase A1 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="49"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0126641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG57763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="587" mass="63401" checksum="D86ABAABA17EF6D3" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY39</accession>
    <name>Q6FY39_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Candida glabrata strain CBS138 chromosome A complete sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4" type="ordered locus">CAGL0A02255g</name>
        <name evidence="3 5" type="ordered locus">CAGL0A02277g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65</strain>
            <strain evidence="5">CBS 138</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2008-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Sherman D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444862.1">
        <property type="nucleotide sequence ID" value="XM_444862.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444863.1">
        <property type="nucleotide sequence ID" value="XM_444863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY39"/>
    <dbReference type="FunCoup" id="Q6FY39">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY39"/>
    <dbReference type="KEGG" id="cgr:2886318"/>
    <dbReference type="KEGG" id="cgr:2886474"/>
    <dbReference type="CGD" id="CAL0126531">
        <property type="gene designation" value="CAGL0A02255g"/>
    </dbReference>
    <dbReference type="CGD" id="CAL0126737">
        <property type="gene designation" value="CAGL0A02277g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02255g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02277g"/>
    <dbReference type="eggNOG" id="ENOG502S1C8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070145_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY39"/>
    <dbReference type="OMA" id="WETASGC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007708199" evidence="1">
        <location>
            <begin position="25"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0126531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0126737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG57755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG57756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="272" mass="29989" checksum="3D3D96E9450FC633" modified="2004-07-19" version="1">MKFGGFSTLTQAAAALALFNAVDAFDASSPGRTDLNTTEIDTGAFLGDLDVVKVPESANLSEYILTYAGSDKALLDEKTGYVLLNITQNYAGNDTMAKRDVKVYGYDGWYQTWHQMQTVNKGEWWSPWYPISQCVSNGLNDAEASISVNFAYTYTWSLEWGLNAGPDVVGASIGYSISDSVGWGGQFQCNIAPHTRGQIWYQQRVAWADIQKQDCRRENNGKVTCSPWSAFNRVNAPLKGADNVHLGCSSGEDNIQCDAHFDSRLGQIFRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FYA2</accession>
    <name>Q6FYA2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0A03828g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FYA2"/>
    <dbReference type="FunCoup" id="Q6FYA2">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FYA2"/>
    <dbReference type="KEGG" id="cgr:2886327"/>
    <dbReference type="CGD" id="CAL0126867">
        <property type="gene designation" value="CAGL0A03828g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A03828g"/>
    <dbReference type="eggNOG" id="ENOG502QRI8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029881_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FYA2"/>
    <dbReference type="OMA" id="WAPIREP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005621">
        <property type="term" value="C:cellular bud scar"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007120">
        <property type="term" value="P:axial cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007121">
        <property type="term" value="P:bipolar cellular bud site selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="185"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0126867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG57826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="476" mass="55332" checksum="57101397960128C6" modified="2004-07-19" version="1">MPSTAIDFDQIQHQRLPTLYEVFILKTEPPVDLWSFYTYLSQFPYAINYLDFWIDLMAHIRLCKDYVSTVRQSVVQGSALEEFRNLDERSNVNRHMNNDEDASVTTSILMNTLLSEGYLDFENPEKVSQFLQGNTHTSPMVTRMIQDWKLHNERNSVAATSHLQSTQAGIDISRKESMQSVSAIVDEFLKRQSQLGEKGNITTKQLYNNAQQICNTYLMSQQHSPRYLANIPDDLKNQVIHNFKANRRHDPEVFRELKEVTYQFLETDCFPKFLKEVALHNIHDELSDWRFHPSNKNPHRTSSPSGSKENLNGHKQLMQNHISWSPFSTYTSLSRVLFGCMWMGIGFWIGYVLIFLHYSRAIRVTTVVPFGLGCYYIVCGIYQVDIIYSWFGLTQRLMYSHKKGNIEEGRQVYGATYNDDVPLIFTLLGGKSRLIHIEHPFIKKILYKRGLWCLTLVVIFTAIFTVIFCCVPGRRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q8NJR5</accession>
    <accession>Q6FP16</accession>
    <name>URE2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein URE2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">URE2</name>
        <name type="ordered locus">CAGL0J07392g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2002" name="Proc. Natl. Acad. Sci. U.S.A." volume="99" first="16384" last="16391">
            <title>Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein.</title>
            <authorList>
                <person name="Edskes H.K."/>
                <person name="Wickner R.B."/>
            </authorList>
            <dbReference type="PubMed" id="12177423"/>
            <dbReference type="DOI" id="10.1073/pnas.162349599"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>37A</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AF525167">
        <property type="protein sequence ID" value="AAM91940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448028.1">
        <property type="nucleotide sequence ID" value="XM_448028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q8NJR5"/>
    <dbReference type="SMR" id="Q8NJR5"/>
    <dbReference type="FunCoup" id="Q8NJR5">
        <property type="interactions" value="781"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q8NJR5"/>
    <dbReference type="EnsemblFungi" id="CAGL0J07392g-T">
        <property type="protein sequence ID" value="CAGL0J07392g-T-p1"/>
        <property type="gene ID" value="CAGL0J07392g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889591"/>
    <dbReference type="KEGG" id="cgr:2889591"/>
    <dbReference type="CGD" id="CAL0129812">
        <property type="gene designation" value="URE2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07392g"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011226_14_1_1"/>
    <dbReference type="InParanoid" id="Q8NJR5"/>
    <dbReference type="OMA" id="YEPHRID"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10293">
        <property type="entry name" value="GST_C_Ure2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000034">
        <property type="entry name" value="Transcriptional regulator URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017298">
        <property type="entry name" value="Ure2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037861">
        <property type="entry name" value="Prion_URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0534">Nitrate assimilation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000186005" description="Protein URE2">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="GST N-terminal">
        <location>
            <begin position="113"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal">
        <location>
            <begin position="206"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAM91940." evidence="2" ref="1">
        <original>N</original>
        <variation>S</variation>
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="355" mass="40397" checksum="5CD40F1D37AC12AA" modified="2004-10-11" version="2">MGDSRNTGTISNLSSALRQVNIGSGQDQKNINYEFSNGLNNNVNDNGNHNLVNTNEDNVNKDGSINTNMMSRQVPIQHTHGSQLLQQERMNEQQFNPMEYSRISKFFQNQPMEGYTLFSHRSAPNGFKVSIVLSELGLQYNTIFLDFNLGEHRAPEFVSVNPNARVPALIDHGLENLAIWESGAILLHLVNKFYKETGNPLLWSDDLADQAQINAWLFFQTSGHAPMIGQALHFRYFHTQKIESAVERYTEEVRRVYGVIEMALAERREALIMELDTDNAAAYSAGTTPLSQSRFFDYPVWLVGDKLTIADLSFVPWNNVVDRIGINIKVEFPEVYKWTKHMMRRPAVIKALRGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2025-06-18" version="158" xmlns="https://uniprot.org/uniprot">
    <accession>O74197</accession>
    <accession>Q6FM75</accession>
    <name>PUR6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="3">4.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>AIR carboxylase</fullName>
            <shortName>AIRC</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ADE2</name>
        <name type="ordered locus">CAGL0K10340g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Gene" volume="211" first="395" last="400">
            <title>A high-copy-number ADE2-bearing plasmid for transformation of Candida glabrata.</title>
            <authorList>
                <person name="Hanic-Joyce P.J."/>
                <person name="Joyce P.B.M."/>
            </authorList>
            <dbReference type="PubMed" id="9602176"/>
            <dbReference type="DOI" id="10.1016/S0378-1119(98)00157-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="AF030388">
        <property type="protein sequence ID" value="AAC27548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448669.1">
        <property type="nucleotide sequence ID" value="XM_448669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O74197"/>
    <dbReference type="SMR" id="O74197"/>
    <dbReference type="FunCoup" id="O74197">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="284593.O74197"/>
    <dbReference type="EnsemblFungi" id="CAGL0K10340g-T">
        <property type="protein sequence ID" value="CAGL0K10340g-T-p1"/>
        <property type="gene ID" value="CAGL0K10340g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890129"/>
    <dbReference type="KEGG" id="cgr:2890129"/>
    <dbReference type="CGD" id="CAL0134467">
        <property type="gene designation" value="ADE2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K10340g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10340g"/>
    <dbReference type="eggNOG" id="KOG2835">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_2_1_1"/>
    <dbReference type="InParanoid" id="O74197"/>
    <dbReference type="OMA" id="ITFDHEH"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000030">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000075022" description="Phosphoribosylaminoimidazole carboxylase">
        <location>
            <begin position="1"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="1">
        <location>
            <begin position="110"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="137"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC27548." evidence="2" ref="1">
        <original>MT</original>
        <variation>IA</variation>
        <location>
            <begin position="477"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAC27548." evidence="2" ref="1">
        <original>T</original>
        <variation>F</variation>
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0000305" key="3">
        <source>
            <dbReference type="PubMed" id="9602176"/>
        </source>
    </evidence>
    <sequence length="570" mass="62712" checksum="481BA9042F0C532A" modified="2004-08-16" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2026-01-28" version="157" xmlns="https://uniprot.org/uniprot">
    <accession>O74208</accession>
    <accession>Q6FUK6</accession>
    <name>PDH1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Pleiotropic ABC efflux transporter of multiple drugs PDH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">P leiomorphic drug resistance homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Pleiotropic drug resistance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">PDH1</name>
        <name evidence="28" type="synonym">CDR2</name>
        <name type="synonym">CGR1</name>
        <name type="ordered locus">CAGL0F02717g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Antimicrob. Agents Chemother." volume="42" first="1695" last="1701">
            <title>Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata.</title>
            <authorList>
                <person name="Miyazaki H."/>
                <person name="Miyazaki Y."/>
                <person name="Geber A."/>
                <person name="Parkinson T."/>
                <person name="Hitchcock C."/>
                <person name="Falconer D.J."/>
                <person name="Ward D.J."/>
                <person name="Marsden K."/>
                <person name="Bennett J.E."/>
            </authorList>
            <dbReference type="PubMed" id="9661006"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC 90030 / DSM 11226 / NCCLS 84</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="submission" date="2002-11" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Izumikawa K."/>
                <person name="Miyazaki Y."/>
                <person name="Miyazaki H."/>
                <person name="Bennett J.E."/>
            </authorList>
        </citation>
        <scope>SEQUENCE REVISION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2001" name="Antimicrob. Agents Chemother." volume="45" first="1174" last="1183">
            <title>Role of ATP-binding-cassette transporter genes in high-frequency acquisition of resistance to azole antifungals in Candida glabrata.</title>
            <authorList>
                <person name="Sanglard D."/>
                <person name="Ischer F."/>
                <person name="Bille J."/>
            </authorList>
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    <comment type="function">
        <text evidence="4 5 6 7 8 9 10 11 15 19 20 22 23 24">Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including caspofungin or azoles such as fluconazole, itraconazole, posaconazole, voriconazole, and isavuconazole (PubMed:11257032, PubMed:12244114, PubMed:12557277, PubMed:15105134, PubMed:15388433, PubMed:16803598, PubMed:17581937, PubMed:20038613, PubMed:24273749, PubMed:24838041, PubMed:26482310, PubMed:27486188, PubMed:29371812). Does not play a role in the azole resistance in mature biofilms (PubMed:18651314).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="8 9 10 11 12 13 14 15 16 17 18 21 23 24 25 26 27">Azole exposure induced expression via regulation by the transcription factor PDR1 that stimulates gene expression via binding to elements called pleiotropic drug response elements (PDREs) (PubMed:15388433, PubMed:19148266, PubMed:25199772, PubMed:29464833). Expression is up-regulated in azole-resistant isolates and in presence of fluconazole (PubMed:16803598, PubMed:17581937, PubMed:18782778, PubMed:19196495, PubMed:20038613, PubMed:27486188, PubMed:29371812, PubMed:9661006). Loss of mitochondrial functions leads to increased expression (PubMed:21321146). Expression is temporary increased during the intermediate phase of biofilm development (PubMed:18651314). Expression is down-regulated by the transcription factor STB5 (PubMed:23229483). Expression is negatively regulated by the transcription factor JJJ1 via inactivation of the PDR1 transcriptional pathway (PubMed:29507891). Expression is also decreased by amphotericin B in voriconazole-resistant strains (PubMed:21282443).</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylated by PKA. Dephosphorylated on glucose depletion and independently rephosphorylated during glucose exposure or under stress.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4 6 20">Increases the susceptibility to rhodamine 6G, cycloheximide and chloramphenicol, and also increases rhodamine 6G accumulation (PubMed:12557277). Suppresses the development of high-frequency azole resistance (HFAR) in a medium containing fluconazole (PubMed:11257032). Impairs the blockage of the efflux of fluconazole by milbemycin A4 oxime when CDR1 is also deleted (PubMed:24838041).</text>
    </comment>
    <comment type="similarity">
        <text evidence="30">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
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        <property type="entry name" value="ABC2_membrane"/>
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        <property type="entry name" value="ABC2_membrane_7"/>
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        <property type="entry name" value="ABC_tran"/>
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        <property type="entry name" value="ABC_trans_N"/>
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        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="AAA"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000093439" description="Pleiotropic ABC efflux transporter of multiple drugs PDH1">
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            <begin position="1"/>
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        <location>
            <begin position="1"/>
            <end position="517"/>
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        <location>
            <begin position="518"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="603"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="634"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="773"/>
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            <begin position="793"/>
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            <begin position="1221"/>
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            <begin position="1256"/>
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            <end position="1128"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="24"/>
            <end position="33"/>
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            <begin position="35"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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        </ligand>
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    <feature type="sequence conflict" description="In Ref. 1; AAC31800." evidence="30" ref="1">
        <original>K</original>
        <variation>Q</variation>
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            <position position="438"/>
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        <original>E</original>
        <variation>D</variation>
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        <source>
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        <source>
            <dbReference type="PubMed" id="20038613"/>
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        <source>
            <dbReference type="PubMed" id="21282443"/>
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        <source>
            <dbReference type="PubMed" id="24273749"/>
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        <source>
            <dbReference type="PubMed" id="24838041"/>
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        <source>
            <dbReference type="PubMed" id="25199772"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="26482310"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PubMed" id="27486188"/>
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    </evidence>
    <evidence type="ECO:0000269" key="24">
        <source>
            <dbReference type="PubMed" id="29371812"/>
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    <evidence type="ECO:0000269" key="25">
        <source>
            <dbReference type="PubMed" id="29464833"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="29507891"/>
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    </evidence>
    <evidence type="ECO:0000269" key="27">
        <source>
            <dbReference type="PubMed" id="9661006"/>
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    </evidence>
    <evidence type="ECO:0000303" key="28">
        <source>
            <dbReference type="PubMed" id="11257032"/>
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    </evidence>
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        <source>
            <dbReference type="PubMed" id="9661006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="30"/>
    <sequence length="1542" mass="175026" checksum="2EE22149FD09F669" modified="2004-08-16" version="3"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-10" modified="2026-01-28" version="164" xmlns="https://uniprot.org/uniprot">
    <accession>O93794</accession>
    <accession>Q6FP95</accession>
    <name>TOP2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>DNA topoisomerase 2</fullName>
            <ecNumber evidence="3">5.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>DNA topoisomerase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TOP2</name>
        <name type="ordered locus">CAGL0J05610g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Microbiology" volume="144" first="2407" last="2415">
            <title>A controllable gene-expression system for the pathogenic fungus Candida glabrata.</title>
            <authorList>
                <person name="Nakayama H."/>
                <person name="Izuta M."/>
                <person name="Nagahashi S."/>
                <person name="Sihta E.Y."/>
                <person name="Sato Y."/>
                <person name="Yamazaki T."/>
                <person name="Arisawa M."/>
                <person name="Kitada K."/>
            </authorList>
            <dbReference type="PubMed" id="9782488"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="3">Binds two Mg(2+) per subunit. The magnesium ions form salt bridges with both the protein and the DNA. Can also accept other divalent metal cations, such as Mn(2+) or Ca(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="3"/>
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        <property type="protein sequence ID" value="BAA33955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CAG60900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="CAGL0J05610g-T-p1"/>
        <property type="gene ID" value="CAGL0J05610g"/>
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        <property type="gene designation" value="TOP2"/>
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    <dbReference type="eggNOG" id="KOG0355">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001935_1_0_1"/>
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        <property type="component" value="Chromosome J"/>
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        <property type="term" value="C:DNA replication termination region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
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            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="3">
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            <position position="447"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <note>catalytic</note>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="524"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="524"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <position position="526"/>
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        <ligand>
            <name>Mg(2+)</name>
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        <location>
            <position position="475"/>
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    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="478"/>
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    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
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            <position position="648"/>
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    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
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    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="698"/>
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    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="732"/>
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    </feature>
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        <location>
            <position position="779"/>
        </location>
    </feature>
    <feature type="site" description="Important for DNA bending; intercalates between base pairs of target DNA" evidence="1">
        <location>
            <position position="831"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="906"/>
        </location>
    </feature>
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        <original>G</original>
        <variation>V</variation>
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            <position position="190"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA33955." evidence="6" ref="1">
        <original>R</original>
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            <position position="688"/>
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    </feature>
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        <source>
            <dbReference type="UniProtKB" id="P06786"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00995"/>
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    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1406" mass="161046" checksum="DFAEE38F2598E28B" modified="2004-08-16" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2002-05-10" modified="2026-01-28" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>O93796</accession>
    <accession>Q6FXJ2</accession>
    <name>EF3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 3</fullName>
            <shortName evidence="1">EF-3</shortName>
            <ecNumber evidence="1">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Eukaryotic elongation factor 3</fullName>
            <shortName evidence="1">eEF3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">TEF3</name>
        <name type="ordered locus">CAGL0B03487g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="1998" name="Microbiology" volume="144" first="2407" last="2415">
            <title>A controllable gene-expression system for the pathogenic fungus Candida glabrata.</title>
            <authorList>
                <person name="Nakayama H."/>
                <person name="Izuta M."/>
                <person name="Nagahashi S."/>
                <person name="Sihta E.Y."/>
                <person name="Sato Y."/>
                <person name="Yamazaki T."/>
                <person name="Arisawa M."/>
                <person name="Kitada K."/>
            </authorList>
            <dbReference type="PubMed" id="9782488"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2024" name="Front. Microbiol." volume="15" first="1438900" last="1438900">
            <title>The gene YEF3 function encoding translation elongation factor eEF3 is partially conserved across fungi.</title>
            <authorList>
                <person name="Maldonado G."/>
                <person name="Garcia A."/>
                <person name="Herrero S."/>
                <person name="Castano I."/>
                <person name="Altmann M."/>
                <person name="Fischer R."/>
                <person name="Hernandez G."/>
            </authorList>
            <dbReference type="PubMed" id="39247690"/>
            <dbReference type="DOI" id="10.3389/fmicb.2024.1438900"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="1 4">Ribosome-dependent ATPase that functions in cytoplasmic translation elongation (PubMed:39247690). Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (By similarity). Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (By similarity). Assists translation termination by stimulating the release of nascent protein from the ribosome by release factors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="4">Inviable.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="1"/>
    <dbReference type="EMBL" id="AB012141">
        <property type="protein sequence ID" value="BAA33959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="O93796"/>
    <dbReference type="SMR" id="O93796"/>
    <dbReference type="FunCoup" id="O93796">
        <property type="interactions" value="732"/>
    </dbReference>
    <dbReference type="STRING" id="284593.O93796"/>
    <dbReference type="EnsemblFungi" id="CAGL0B03487g-T">
        <property type="protein sequence ID" value="CAGL0B03487g-T-p1"/>
        <property type="gene ID" value="CAGL0B03487g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886522"/>
    <dbReference type="CGD" id="CAL0127772">
        <property type="gene designation" value="TEF3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_B03487g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B03487g"/>
    <dbReference type="eggNOG" id="KOG0062">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1242">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002848_0_0_1"/>
    <dbReference type="InParanoid" id="O93796"/>
    <dbReference type="OMA" id="VLSEAMW"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1390.20:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000001">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040533">
        <property type="entry name" value="EF3_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047036">
        <property type="entry name" value="EF3_4HB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF5">
        <property type="entry name" value="ELONGATION FACTOR 3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17947">
        <property type="entry name" value="4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000093455" description="Elongation factor 3">
        <location>
            <begin position="1"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 1">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 2">
        <location>
            <begin position="43"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 3">
        <location>
            <begin position="86"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 4">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 5">
        <location>
            <begin position="166"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 6">
        <location>
            <begin position="205"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT 7">
        <location>
            <begin position="242"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 1" evidence="2">
        <location>
            <begin position="426"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter 2" evidence="2">
        <location>
            <begin position="667"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="974"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="922"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="925"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="951"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA33959." evidence="5" ref="1">
        <original>A</original>
        <variation>T</variation>
        <location>
            <position position="854"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA33959." evidence="5" ref="1">
        <original>K</original>
        <variation>R</variation>
        <location>
            <position position="873"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA33959." evidence="5" ref="1">
        <original>E</original>
        <variation>K</variation>
        <location>
            <position position="887"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA33959." evidence="5" ref="1">
        <original>V</original>
        <variation>F</variation>
        <location>
            <position position="963"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA33959." evidence="5" ref="1">
        <original>M</original>
        <variation>I</variation>
        <location>
            <position position="971"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; BAA33959." evidence="5" ref="1">
        <original>K</original>
        <variation>R</variation>
        <location>
            <position position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P16521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="39247690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="1045" mass="115896" checksum="12E91A1A0DDCE9EE" modified="2004-08-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ03</accession>
    <name>Q6FJ03_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LAC1</name>
        <name evidence="12 13" type="ordered locus">CAGL0M10219g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ03"/>
    <dbReference type="STRING" id="284593.Q6FJ03"/>
    <dbReference type="KEGG" id="cgr:2891355"/>
    <dbReference type="CGD" id="CAL0137027">
        <property type="gene designation" value="LAC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M10219g"/>
    <dbReference type="eggNOG" id="KOG1607">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028277_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ03"/>
    <dbReference type="OMA" id="THAAEFK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF11">
        <property type="entry name" value="CERAMIDE SYNTHASE LAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005225">
        <property type="entry name" value="LAG1_LAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="185"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="230"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="260"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="311"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="366"/>
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    </feature>
    <feature type="domain" description="TLC" evidence="11">
        <location>
            <begin position="158"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50922"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0137027"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG62769.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
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    </evidence>
    <sequence length="397" mass="47215" checksum="6149F1C9ED093EA2" modified="2004-07-19" version="1">MLKVETKQRPRRASSVGNIDLGDTVPGFATMHESKASKVAAKRRHERLATQRNLKMTTKLYLKARDYNYHHMWFLPLCILILTYAAYFGISNKRVKGFLHMFVAISYEQESNPQYYGKGIKDLAFVFFHMIFFTFLREFLMDVIIRRITQWLNITSKYKIKRMMEQMFSIFYYGFSSPFGVYVMYHSDLWYFRTNTMYNTYPDILIPKLFKAFYLIQAAFWAQQAFVLVLQLEKPRKDHKELCFHHVVTLLLIWSSYVFHFHKMGLAVYITMDVSDFFLALSKTLNYIDSPLTEVVFGMFVLVWIYLRHVINGKILWSVLTEFRTEGPYILNFATQQYKCWISLPIVFVLIFALQVLNIYWLFLIFKVLYKIVWQGVTEDVRSDEETDSGSDELKKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ81</accession>
    <name>MCD4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber>2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MCD4</name>
        <name type="ordered locus">CAGL0M08448g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text>Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449713.1">
        <property type="nucleotide sequence ID" value="XM_449713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ81"/>
    <dbReference type="SMR" id="Q6FJ81"/>
    <dbReference type="FunCoup" id="Q6FJ81">
        <property type="interactions" value="514"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ81"/>
    <dbReference type="GlyCosmos" id="Q6FJ81">
        <property type="glycosylation" value="6 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0M08448g-T">
        <property type="protein sequence ID" value="CAGL0M08448g-T-p1"/>
        <property type="gene ID" value="CAGL0M08448g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891272"/>
    <dbReference type="KEGG" id="cgr:2891272"/>
    <dbReference type="CGD" id="CAL0136323">
        <property type="gene designation" value="CAGL0M08448g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08448g"/>
    <dbReference type="eggNOG" id="KOG2124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007676_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ81"/>
    <dbReference type="OMA" id="QSYFHRE"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015867">
        <property type="term" value="P:ATP transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000015">
        <property type="entry name" value="GPI ethanolamine phosphate transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017852">
        <property type="entry name" value="GPI_EtnP_transferase_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04987">
        <property type="entry name" value="PigN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000246204" description="GPI ethanolamine phosphate transferase 1">
        <location>
            <begin position="1"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="30"/>
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    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="871"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="879"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="900"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="909"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="921" mass="104729" checksum="C4C6C79B953798FE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJB8</accession>
    <name>Q6FJB8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TrmE-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M07546g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJB8"/>
    <dbReference type="FunCoup" id="Q6FJB8">
        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJB8"/>
    <dbReference type="KEGG" id="cgr:2891726"/>
    <dbReference type="CGD" id="CAL0136635">
        <property type="gene designation" value="CAGL0M07546g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07546g"/>
    <dbReference type="eggNOG" id="KOG1191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FJB8"/>
    <dbReference type="OMA" id="EFHCHGG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070899">
        <property type="term" value="P:mitochondrial tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000007">
        <property type="entry name" value="tRNA modification GTPase GTPBP3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003661">
        <property type="entry name" value="PRK05291.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="7">
        <location>
            <begin position="238"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="487" mass="53700" checksum="74E252CC08289B5F" modified="2004-07-19" version="1">MVGIRFLSHTRQRLPTIYSMVTPRAKSAVSVIRVSGDKAQYVYRKLTRRDDVPRSRQACLRGLYNGDNELIDRALVLYFKSPGSFTGEDVVEFQVHGGRAVSESVLSAIGSLNNRDQDVEIRMADRGEFSRRSFLNGKADLTGLEGINTLINADTEAQRRAAMGSFTGKNKALFNRWRDIAIQNSAQLTAIIDFSEDSDFADEYTAVMAEVRQELMGLRTEIGNFIARVTKASIVENGINMTLLGAPNVGKSSLLNQIASDDISIVSDIPGTTRDIVSSIVNINGYKVNLFDTAGIRVDTTDPIEKMGIEKAFKRIGSSDICICVIDGTQPLPLNVLDLLKSSDLSGSEIIFVVNKIDIVDDSCKLSKIQQYIGNNLTGCKICFVSCLKSTGIDELVTVLTGKFKTLTQNEENEDPIIVSDRVKEILEKDVLYGIDQFLQIQDDMHDIVIATEHLRYVIDGIGKITGEVIGLEEVLDVVFSKFCVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJM1</accession>
    <name>Q6FJM1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein RIM2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0M05225g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-methyl-UTP(out) + UTP(in) = 5-methyl-UTP(in) + UTP(out)</text>
            <dbReference type="Rhea" id="RHEA:73523"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:63527"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJM1"/>
    <dbReference type="FunCoup" id="Q6FJM1">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJM1"/>
    <dbReference type="KEGG" id="cgr:2891585"/>
    <dbReference type="CGD" id="CAL0136415">
        <property type="gene designation" value="CAGL0M05225g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05225g"/>
    <dbReference type="eggNOG" id="KOG0757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_6_0_1"/>
    <dbReference type="InParanoid" id="Q6FJM1"/>
    <dbReference type="OMA" id="WVMYEQM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000079">
        <property type="entry name" value="Mitochondrial carrier protein RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000088">
        <property type="entry name" value="Mitochondrial carrier protein RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="54"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="177"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="288"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0136415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG62549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42803" checksum="7DF6C04EAB679D18" modified="2004-07-19" version="1">MPKRTLEEWEEDAMESVPYLASDEKGSNYREATQPVILEDSKIVQPKLEVHKTVKPWVHFLAGGIGGMAGAVVTCPFDLVKTRLQSDIYQNMYKSQAEALMMNTTRPRIVNLTLQAATHFKETVSIIGNVYRQEGFRSLFKGLGPNLVGVIPARSINFFTYGTTKDIYSKAFNNGQEAPWIHLMAAATAGWATATATNPIWMVKTRVQLDKAGKTRTYKNSYDCLKSILRNEGIYGLYRGLSASYLGSVEGILQWLLYEQLKHLIKKRSIEKFGAHDESTMTTTDKIKQWCQRSGGAGLAKFMASIVTYPHEVVRTRLRQSPLENGKVKYTGLVQSFRVIIKEEGLASMYSGLTPHLMRTVPNSIIMFGTWEVVIKLLSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJQ3</accession>
    <name>Q6FJQ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sigma-like sequence protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0M04455g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJQ3"/>
    <dbReference type="FunCoup" id="Q6FJQ3">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJQ3"/>
    <dbReference type="KEGG" id="cgr:2891550"/>
    <dbReference type="CGD" id="CAL0137217">
        <property type="gene designation" value="CAGL0M04455g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04455g"/>
    <dbReference type="eggNOG" id="ENOG502QUD1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_390400_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJQ3"/>
    <dbReference type="OMA" id="LWFELDE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032741">
        <property type="entry name" value="Sls1_KH-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048748">
        <property type="entry name" value="SLS1_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048400">
        <property type="entry name" value="SLS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14611">
        <property type="entry name" value="KH_SLS1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20777">
        <property type="entry name" value="KH_SLS1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20776">
        <property type="entry name" value="SLS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLS1 N-terminal" evidence="2">
        <location>
            <begin position="137"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 first KH" evidence="1">
        <location>
            <begin position="221"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 second KH" evidence="3">
        <location>
            <begin position="300"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="SLS1 C-terminal" evidence="4">
        <location>
            <begin position="394"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0137217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="82130" checksum="54ACEC7151D5E593" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJV5</accession>
    <name>Q6FJV5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0M03267g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJV5"/>
    <dbReference type="FunCoup" id="Q6FJV5">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJV5"/>
    <dbReference type="KEGG" id="cgr:2891497"/>
    <dbReference type="CGD" id="CAL0136821">
        <property type="gene designation" value="CAGL0M03267g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M03267g"/>
    <dbReference type="eggNOG" id="KOG2979">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088986_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJV5"/>
    <dbReference type="OMA" id="IELICPI"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030291">
        <property type="term" value="F:protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054753">
        <property type="entry name" value="MMS21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22326">
        <property type="entry name" value="MMS21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="12">
        <location>
            <begin position="172"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="36"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0136821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG62465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="266" mass="30800" checksum="FEE314591D19CFFD" modified="2004-07-19" version="1">MDSVALPEALPIHKDQRDNFHDLRECYISSELSTIEKQYEKTINQLTTYIDLLEEDQILQCVNKLTESYKDTLAQKEQADQLDNQLESLKQDYLRISDHSPATDIDSFREYTNGTVGIDSFQKYFTEGIVDQKPTIPRNNVRRKPNTYEKLLKALPYIIRDPTCVIPDEDQEEDDIQIEGGKIELNCPITCKPFENPMISKACNHVFDKVGIQMYFDTPDKKKCPQGACGHELTARDFIPDNIMMLRCKINNRKKNDQARNMLDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKA0</accession>
    <name>Q6FKA0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SIC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L13222g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKA0"/>
    <dbReference type="FunCoup" id="Q6FKA0">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKA0"/>
    <dbReference type="KEGG" id="cgr:2890594"/>
    <dbReference type="CGD" id="CAL0135604">
        <property type="gene designation" value="CAGL0L13222g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L13222g"/>
    <dbReference type="eggNOG" id="ENOG502S3ZS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086083_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKA0"/>
    <dbReference type="OMA" id="KNWNNNS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905761">
        <property type="term" value="F:SCF ubiquitin ligase complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31551" checksum="02DD9D853D08C709" modified="2004-07-19" version="1">MTPSTPPRSRQRRHDSGSLEMHGYGDSVMGTPQRSQLLAPVTPSTVQKFKSVPALQPQKTTFNGLKSPERSPFPLQGRRGSVKRTFGDDAGAGCDSGCDSLLGDASGKYKSITKTLFAEETEPLFPPETSTSPSRSSSPLQLPKLQLSHIRDAENDEQIRKMAKQVPGTPSDKVITFEMAQDWNNVSSKDGTTNSDTEDDLLVTKKPLKNPFASDDVIDETERRRRHNQLLKENPELESTISYVNKNGEVVKQRHLSLEDQIRYKPRALFTKEIEELKRDKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2025-06-18" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKA5</accession>
    <name>MED14_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RGR1</name>
        <name type="synonym">MED14</name>
        <name type="ordered locus">CAGL0L13112g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449339.1">
        <property type="nucleotide sequence ID" value="XM_449339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKA5"/>
    <dbReference type="SMR" id="Q6FKA5"/>
    <dbReference type="FunCoup" id="Q6FKA5">
        <property type="interactions" value="310"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKA5"/>
    <dbReference type="EnsemblFungi" id="CAGL0L13112g-T">
        <property type="protein sequence ID" value="CAGL0L13112g-T-p1"/>
        <property type="gene ID" value="CAGL0L13112g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890589"/>
    <dbReference type="KEGG" id="cgr:2890589"/>
    <dbReference type="CGD" id="CAL0135684">
        <property type="gene designation" value="RGR1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L13112g"/>
    <dbReference type="eggNOG" id="KOG1875">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_286680_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKA5"/>
    <dbReference type="OMA" id="MIDLLNW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001093">
        <property type="term" value="F:TFIIB-class transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000304598" description="Mediator of RNA polymerase II transcription subunit 14">
        <location>
            <begin position="1"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="1037" mass="119213" checksum="D974201B7CDDCC6F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-06-28" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKB4</accession>
    <name>EIS1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Eisosome protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EIS1</name>
        <name type="ordered locus">CAGL0L12914g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for normal formation of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on plasma membrane and mark the site of endocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="1">Localizes at the eisosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EIS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449330.1">
        <property type="nucleotide sequence ID" value="XM_449330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKB4"/>
    <dbReference type="SMR" id="Q6FKB4"/>
    <dbReference type="FunCoup" id="Q6FKB4">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKB4"/>
    <dbReference type="EnsemblFungi" id="CAGL0L12914g-T">
        <property type="protein sequence ID" value="CAGL0L12914g-T-p1"/>
        <property type="gene ID" value="CAGL0L12914g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890580"/>
    <dbReference type="CGD" id="CAL0135934">
        <property type="gene designation" value="CAGL0L12914g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12914g"/>
    <dbReference type="eggNOG" id="ENOG502S8WV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013228_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKB4"/>
    <dbReference type="OMA" id="EHTFSGF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024527">
        <property type="entry name" value="Eisosome1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298:SF1">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12757">
        <property type="entry name" value="Eisosome1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000410799" description="Eisosome protein 1">
        <location>
            <begin position="1"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="726"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="873"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="885" mass="97546" checksum="325C778DBE025364" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKC9</accession>
    <name>Q6FKC9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L12584g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449315.1">
        <property type="nucleotide sequence ID" value="XM_449315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKC9"/>
    <dbReference type="FunCoup" id="Q6FKC9">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890601"/>
    <dbReference type="CGD" id="CAL0135878">
        <property type="gene designation" value="CAGL0L12584g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12584g"/>
    <dbReference type="eggNOG" id="ENOG502RZVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089385_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKC9"/>
    <dbReference type="OMA" id="TNTHEDF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="294" mass="33649" checksum="4D5EDA4F4A076A56" modified="2004-07-19" version="1">MVKSLFGEKSLRNGARSQLELNKFLIHKFLKSVLAKYSLLLQPSPPGNDLASLCRIFEGILIRVRGNRAQFKKVCCIIIKFLECCHNEYNYMQFLKHDLKRLLVTAFVLSVPNNGTDEAERSIIRDKIYTCYSNVTGLKEEEIINCCSITRPILIRRSREQYKAIRYKQMKDARRERDPRIIQLTNDMNEDTATMSDLALHNFLEPFDITSTFTFTKRNNIGTSAPASLGASMMLNMSRTDPTDPWNGSTGAPPSSEYYNNTDGSVSNEYVLGTEIQRFNEITKKLIQSNFNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKZ3</accession>
    <name>Q6FKZ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PHO2</name>
        <name evidence="9 10" type="ordered locus">CAGL0L07436g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449101.1">
        <property type="nucleotide sequence ID" value="XM_449101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKZ3"/>
    <dbReference type="FunCoup" id="Q6FKZ3">
        <property type="interactions" value="1001"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKZ3"/>
    <dbReference type="GeneID" id="2890989"/>
    <dbReference type="KEGG" id="cgr:2890989"/>
    <dbReference type="CGD" id="CAL0135048">
        <property type="gene designation" value="PHO2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07436g"/>
    <dbReference type="eggNOG" id="KOG0486">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028430_2_0_1"/>
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        <location>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50071"/>
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            <dbReference type="CGD" id="CAL0135048"/>
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        <source>
            <dbReference type="EMBL" id="CAG62071.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
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    <sequence length="515" mass="56232" checksum="5F250D3243014CEB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL42</accession>
    <name>Q6FL42_CANGA</name>
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        <recommendedName>
            <fullName evidence="10">Membrane protein TMS1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7 8" type="ordered locus">CAGL0L06358g</name>
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    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
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    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the TDE1 family.</text>
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    <dbReference type="eggNOG" id="KOG2592">
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        <property type="component" value="Chromosome L"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:fungal-type vacuole membrane"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
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        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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            <end position="28"/>
        </location>
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            <end position="104"/>
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        <location>
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            <end position="146"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="215"/>
        </location>
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            <end position="244"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0135836"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="CAG62022.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="53121" checksum="E32890730E1416B5" modified="2004-07-19" version="1">MGAIISLPISAASTFTFSMLSGCCFNLLSNIASKVGSSSLGVRLLYAIWLLMNSLLSWITLSANKSLLFPGKSCTSTGECGFFTVHRLNFALGMLHLILAGALIKVKSTKDARATIQNSWWSLKFLTYILLIVASFLIPNEFYIFFSKWVSVPSGVIFILVGLILLVDFAHEWAETCIFHVEQEDENSNFWKNFLVAGTASMYTGAIAMTIAMYIVFCRDNCNMNKVAVNMNLVLILITLIIAIHPRVQQSNPKSGLAQSSMVAFYCTYLTMSAMASEPDDKMCNPLVRSNGTRKASVILGSLFTFVAIAYTTTRAAANSAFQGSAAEGPIYLPDDIEYEGLGGQSRNQLRYEAIKQAVEEGSLPESALYDHSWMGASPSLNNRNETELDINDDEVNGTQYNYSLFHVIFFLATQWIAILLTINVTHDDVGNFVPVGRTYFYSWVKIVSAWICYGLYSWTVLAPVFMPYRFDYEDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL43</accession>
    <name>Q6FL43_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0L06336g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL43"/>
    <dbReference type="FunCoup" id="Q6FL43">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="IntAct" id="Q6FL43">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL43"/>
    <dbReference type="KEGG" id="cgr:2890759"/>
    <dbReference type="CGD" id="CAL0135082">
        <property type="gene designation" value="CAGL0L06336g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06336g"/>
    <dbReference type="eggNOG" id="ENOG502QQID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013813_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL43"/>
    <dbReference type="OMA" id="SHQECLI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11070">
        <property type="entry name" value="Protein Ste5, Fus3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038382">
        <property type="entry name" value="Ste5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021106">
        <property type="entry name" value="Ste5_Fus3-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12194">
        <property type="entry name" value="Ste5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0135082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG62021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="600" mass="69720" checksum="F594FB8783E55167" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL85</accession>
    <name>Q6FL85_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L05390g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL85"/>
    <dbReference type="FunCoup" id="Q6FL85">
        <property type="interactions" value="762"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL85"/>
    <dbReference type="KEGG" id="cgr:2890788"/>
    <dbReference type="CGD" id="CAL0135896">
        <property type="gene designation" value="CAGL0L05390g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05390g"/>
    <dbReference type="eggNOG" id="KOG1876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084855_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FL85"/>
    <dbReference type="OMA" id="EAYLGEF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="171" mass="19949" checksum="AFF234F620FBA18C" modified="2004-07-19" version="1">MSQSLRPYLNAVRYSLQAALTLSDFSSLEVERHNRPEVEVPNTSAELLLQPMHISRNEHEQVLIEPSVNSVRVSLKVKQADEIEQILVHKFTRFLEQRAEAFYILRRVPIPGYSISFLITNKHTESMKTNKLVDFIVEFMEEVDKEISEMKLFLNARARFVAEAYLSEFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLC6</accession>
    <name>Q6FLC6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Golgi to ER traffic protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L04444g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLC6"/>
    <dbReference type="FunCoup" id="Q6FLC6">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLC6"/>
    <dbReference type="KEGG" id="cgr:2890638"/>
    <dbReference type="CGD" id="CAL0136186">
        <property type="gene designation" value="CAGL0L04444g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04444g"/>
    <dbReference type="eggNOG" id="KOG3024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046061_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FLC6"/>
    <dbReference type="OMA" id="LMDMMGM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000615">
        <property type="entry name" value="Golgi to ER traffic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34854" checksum="10BFD98A661464ED" modified="2004-07-19" version="1">MDSAVGAKLAKTLQRFESRIAAGDYYEAHQTLRTIANRYVRSKSYDHAIELINQGALSFLKAKQGGSASDLIFYLLEVYDVADIKVSETSVGRLAQLLVLVDDQEPNLKDIVTGMNNWSIKHSEFKFGDPTLHNVIGNKLVAGGLVYEAERYYMLGTHESVGKYVDLLWSWFTQANDNSSVADYFSRLVMNYLFIQNIAYAYEAKELFLKKFIDHVSPKVQTVDKNSFKLNYFNDYSDLNFLQLLLLTCQTGNKDLFQNLKEHYSESASKYKNELSYLGQEYFGITAPKQSNFLQDMMSGFLGGPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLW9</accession>
    <name>Q6FLW9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SEC53</name>
        <name evidence="14 15" type="ordered locus">CAGL0K12848g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448775.1">
        <property type="nucleotide sequence ID" value="XM_448775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLW9"/>
    <dbReference type="FunCoup" id="Q6FLW9">
        <property type="interactions" value="777"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLW9"/>
    <dbReference type="GeneID" id="2890430"/>
    <dbReference type="KEGG" id="cgr:2890430"/>
    <dbReference type="CGD" id="CAL0134763">
        <property type="gene designation" value="SEC53"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12848g"/>
    <dbReference type="eggNOG" id="KOG3189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065642_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FLW9"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005002">
        <property type="entry name" value="PMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043169">
        <property type="entry name" value="PMM_cap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10466:SF0">
        <property type="entry name" value="PHOSPHOMANNOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03332">
        <property type="entry name" value="PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00445">
        <property type="entry name" value="alpha-phosphomannomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01143">
        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605002-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0134763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG61738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="255" mass="29150" checksum="FFBFE76A19A6A3B9" modified="2004-07-19" version="1">MSTPQEFAYKERPDVLVLFDVDGTLTPARLTVSDKVRDTLVKLRKKVCIGFVGGSDLSKQLEQLGPNVLNEFDYAFSENGLTAYRMGKQLASQSFINWIGEEKYNKLAKFILGYLANIDLPKRRGTFLEFRNGMINVSPIGRNASTEERNEFERYDKEHNIRAKFVEALKKEFPDYGLTYSIGGQISFDVFPTGWDKTYCLQHVEKDGFKEIHFFGDKTQVGGNDYEIFVDPRTIGHSVQTPDDTVKILNEIFNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-09-13" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLZ2</accession>
    <name>ALG1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.142</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Asparagine-linked glycosylation protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Beta-1,4-mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>GDP-mannose-dolichol diphosphochitobiose mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ALG1</name>
        <name type="ordered locus">CAGL0K12342g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N,N'-diacetylchitobiosyl-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13865"/>
            <dbReference type="Rhea" id="RHEA-COMP:19510"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57269"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="EC" id="2.4.1.142"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13866"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="1"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448752.1">
        <property type="nucleotide sequence ID" value="XM_448752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLZ2"/>
    <dbReference type="SMR" id="Q6FLZ2"/>
    <dbReference type="FunCoup" id="Q6FLZ2">
        <property type="interactions" value="962"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLZ2"/>
    <dbReference type="CAZy" id="GT33">
        <property type="family name" value="Glycosyltransferase Family 33"/>
    </dbReference>
    <dbReference type="GlyCosmos" id="Q6FLZ2">
        <property type="glycosylation" value="3 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0K12342g-T">
        <property type="protein sequence ID" value="CAGL0K12342g-T-p1"/>
        <property type="gene ID" value="CAGL0K12342g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889981"/>
    <dbReference type="KEGG" id="cgr:2889981"/>
    <dbReference type="CGD" id="CAL0134263">
        <property type="gene designation" value="CAGL0K12342g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12342g"/>
    <dbReference type="eggNOG" id="KOG2941">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012079_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLZ2"/>
    <dbReference type="OMA" id="CKLIIDW"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000216">
        <property type="entry name" value="Chitobiosyldiphosphodolichol beta-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0735">Signal-anchor</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000080254" description="Chitobiosyldiphosphodolichol beta-mannosyltransferase">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="35"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="128"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P16661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="450" mass="51945" checksum="23D405BAF7FB7724" modified="2004-07-19" version="1">MSWIQIPWSWVVTLIVTYLSLPLIIYYLVPYIFYGNKSSKKRIIIYVLGDIGHSPRMCYHARSFSEKGWQVELCGYVEEQVPGFIAEDPNIIVHALPTLTLQGNKRSIIFLVKKVLFQVSAIIAQLWELRGSNYMLIQNPPSIPILPIAVFYRLSGCKLIIDWHNLAYSIMQLKFNGNFYHPVVLASYVIEYIFGKFATYNLTVTEAMKEYLVNSFGLNPKRCVVLYDRPATQFKPLTESESRTKLLDSEFIRDMIPEGFNVEKGDKIIVTSTSFTPDEDISILIGALKIYDNSYENLDKSLPKILCFVTGKGPMKERYVKDVEEHDWQHVYVKFVWLKSEDYPRLLQLCDYGVSLHKSSSGLDLPMKILDMYGSGIPVIAYNYPVLGELVKYNENGLKFLDRRELHESLIFAMKDPELYKKLKQGALKESQIRWNSSWQSAMQELKLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLZ6</accession>
    <name>Q6FLZ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar import and degradation protein 24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0K12254g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLZ6"/>
    <dbReference type="FunCoup" id="Q6FLZ6">
        <property type="interactions" value="342"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLZ6"/>
    <dbReference type="KEGG" id="cgr:2889977"/>
    <dbReference type="CGD" id="CAL0134891">
        <property type="gene designation" value="CAGL0K12254g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12254g"/>
    <dbReference type="eggNOG" id="KOG4635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028759_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FLZ6"/>
    <dbReference type="OMA" id="NILGFYY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0134891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="39021" checksum="F468B5DAA98067F8" modified="2004-07-19" version="1">MIEQDVTLKKKHSLRKNVLQYNSYTRDGSVSPIERPLEGLYKCHSKDSLPSLQHLIDRSSSESLPLKKKKKYIMNDRSSYTTVSVPRYVTPTHKNTTQTNFLRPRLEFSGYQLSGYKRYQVNVSLKTVDLPTVESGNTTTTPHITGYLTIKGLTSQHPEITTFFEAYAVEHNELGFLSSQWPEENNYEPYKSDDQTDLEHWLNFPAFRELFIAQHANLVKEDEEATPDFKKKRQSINTLAELFMENQAQNEGRNYLNDRYIFMRWKEKFLVPDAFVENVDGASYDGFYYVVHDQLTGCMQGFYYHQDAERFQQLELVPCKKAQDLCNSSCTFELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM12</accession>
    <name>Q6FM12_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein MRH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K11880g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM12"/>
    <dbReference type="KEGG" id="cgr:2889959"/>
    <dbReference type="CGD" id="CAL0134125">
        <property type="gene designation" value="CAGL0K11880g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11880g"/>
    <dbReference type="eggNOG" id="ENOG502QQVQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054785_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FM12"/>
    <dbReference type="OMA" id="GHWNIDP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35107" checksum="2992E6A7C5E304DD" modified="2004-07-19" version="1">MSYVDLYKRGGNEAVKINPPTGADFHITSRGSDWAWAVFCVMFFCAIVMVLLMFRKTANDRLAYYTAIAPCVFMGIAYFTIASNLGWIPVRAKYNHVRTSTQQQHPGVRQIFYARYVGWFMALPWPVIQASLMGKTPIWQIAFNIAMTEVFTVCFLIAACVHSTYKWGYMTIGCGGAIVAMISVMTTTRHLVRAKKDGELWKGFNIYFGLVMFFWAIYPICFGITDGGNVLQPDSALIFYGILDIILYAFLPCLWVPIASYIGISNMGYNFSDAEAGMTTSNTMATVASPAMSPTPKTPKTPKTPATGKKAKKSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMC9</accession>
    <name>Q6FMC9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0K09064g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMC9"/>
    <dbReference type="FunCoup" id="Q6FMC9">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMC9"/>
    <dbReference type="KEGG" id="cgr:2890246"/>
    <dbReference type="CGD" id="CAL0133833">
        <property type="gene designation" value="CAGL0K09064g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K09064g"/>
    <dbReference type="eggNOG" id="KOG1529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031618_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FMC9"/>
    <dbReference type="OMA" id="NNNWFAS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000069">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000070">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="3">
        <location>
            <begin position="175"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0133833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="302" mass="34359" checksum="6A1AB5156F2807CE" modified="2004-07-19" version="1">MSLFKLITPCAFVELTKASKKVVPVDSTWYLPNLKRDGKQEFMDVERIPGAVYFDIDDIRDSASEFPHMAPDLATFNEGMSQLGVNKEDILVVYDRIGNFSAPRCAWTLVMLGHPEVYLLNNFNAYKKEGYPLDTTKWTKLTQYPKSNYKSETNLCPENVITYEQMLELVKSGELKKKYNVYDARALNRFEGKAPEPRPDISSGHVAGVQPLPFTEILDQPDLTFPQEQVDMEKKVQEAFKKLNNTYDPSKPTIVMCGTGVSACIIRTALEHSGVKDIKLYDGSWVEWVLRSDPKLIAKDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FME5</accession>
    <name>Q6FME5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0K08690g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448599.1">
        <property type="nucleotide sequence ID" value="XM_448599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FME5"/>
    <dbReference type="KEGG" id="cgr:2890280"/>
    <dbReference type="CGD" id="CAL0134253">
        <property type="gene designation" value="CAGL0K08690g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K08690g"/>
    <dbReference type="eggNOG" id="ENOG502S0J5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_497813_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FME5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0134253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="547" mass="60333" checksum="209BEC39BAF693F1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMP6</accession>
    <name>Q6FMP6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inner nuclear membrane protein SRC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0K06325g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMP6"/>
    <dbReference type="STRING" id="284593.Q6FMP6"/>
    <dbReference type="KEGG" id="cgr:2890463"/>
    <dbReference type="CGD" id="CAL0134565">
        <property type="gene designation" value="CAGL0K06325g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06325g"/>
    <dbReference type="eggNOG" id="ENOG502QVG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_448321_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMP6"/>
    <dbReference type="OMA" id="YILSEPW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="HeH/LEM" evidence="10">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="9">
        <location>
            <begin position="277"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0134565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="69832" checksum="B8AE05F7A17488EE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMR0</accession>
    <name>Q6FMR0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GTP-binding protein YPT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K06017g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Lipid-anchor</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMR0"/>
    <dbReference type="FunCoup" id="Q6FMR0">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMR0"/>
    <dbReference type="KEGG" id="cgr:2890449"/>
    <dbReference type="CGD" id="CAL0134801">
        <property type="gene designation" value="CAGL0K06017g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06017g"/>
    <dbReference type="eggNOG" id="KOG0094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041217_10_2_1"/>
    <dbReference type="InParanoid" id="Q6FMR0"/>
    <dbReference type="OMA" id="PVSNDGC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000301">
        <property type="term" value="P:retrograde transport, vesicle recycling within Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000970">
        <property type="entry name" value="Ras-related protein Rab-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24641" checksum="2C6C279FB5151545" modified="2004-07-19" version="1">MSGRQDKLLTKYKIVFLGEQGVGKTSLITRFMYDTFDDNYQATIGIDFLSKTMYLDDKTIRLQLWDTAGQERFRSLIPSYIRDSRVAIVVYDITKRKSFEFIDKWIEDVKNERGAENVILCVVGNKSDLADERQVTAEEGEKKAQDLGAKIFMQTSTKVGYNVKNLFKKIAKSLPEFQDSDANPLENTGGAAGNRNSNKAGVIDISTTDEDQSQSGCQC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN16</accession>
    <name>MED11_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mediator of RNA polymerase II transcription subunit 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Mediator complex subunit 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MED11</name>
        <name type="ordered locus">CAGL0K03531g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mediator complex subunit 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448378.1">
        <property type="nucleotide sequence ID" value="XM_448378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN16"/>
    <dbReference type="SMR" id="Q6FN16"/>
    <dbReference type="FunCoup" id="Q6FN16">
        <property type="interactions" value="140"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN16"/>
    <dbReference type="EnsemblFungi" id="CAGL0K03531g-T">
        <property type="protein sequence ID" value="CAGL0K03531g-T-p1"/>
        <property type="gene ID" value="CAGL0K03531g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890179"/>
    <dbReference type="KEGG" id="cgr:2890179"/>
    <dbReference type="CGD" id="CAL0134019">
        <property type="gene designation" value="CAGL0K03531g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K03531g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03531g"/>
    <dbReference type="eggNOG" id="ENOG502S3YW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121031_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FN16"/>
    <dbReference type="OMA" id="IMDDNIG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019404">
        <property type="entry name" value="Mediator_Med11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10280">
        <property type="entry name" value="Med11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000304319" description="Mediator of RNA polymerase II transcription subunit 11">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q99278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="125" mass="14234" checksum="B3BF3BF8DA05AC38" modified="2004-07-19" version="1">MSKSTLEQPEYVKERLESLAEVDRQLCSMLQEASQVAFTYGEVLRGNAMMKPQFQEHVSAFYSTLDNASGKLKKEIELLDENVGNRLLPINVNKKALGQDDDKLKEQMETLKEFLKTDNEETSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNK2</accession>
    <name>Q6FNK2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J11044g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNK2"/>
    <dbReference type="FunCoup" id="Q6FNK2">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="CAZy" id="GT39">
        <property type="family name" value="Glycosyltransferase Family 39"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889521"/>
    <dbReference type="CGD" id="CAL0132964">
        <property type="gene designation" value="CAGL0J11044g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11044g"/>
    <dbReference type="eggNOG" id="KOG3359">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008438_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FNK2"/>
    <dbReference type="OMA" id="SEVYHAD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23286">
        <property type="entry name" value="beta-trefoil_MIR_PMT7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="696"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="3">
        <location>
            <begin position="380"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0132964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="736" mass="85036" checksum="BE4703EE936E75D1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNL5</accession>
    <name>Q6FNL5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="8">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0J10758g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>deamido-NAD(+) + L-glutamine + ATP + H2O = L-glutamate + AMP + diphosphate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="8"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNL5"/>
    <dbReference type="FunCoup" id="Q6FNL5">
        <property type="interactions" value="770"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNL5"/>
    <dbReference type="KEGG" id="cgr:2889617"/>
    <dbReference type="CGD" id="CAL0133676">
        <property type="gene designation" value="CAGL0J10758g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10758g"/>
    <dbReference type="eggNOG" id="KOG2303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011884_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FNL5"/>
    <dbReference type="OMA" id="TSQEVCN"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000003">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="5"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0133676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="713" mass="80702" checksum="45AF44CAE0630FED" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP21</accession>
    <name>Q6FP21_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Guanine nucleotide-binding protein subunit beta 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J07282g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP21"/>
    <dbReference type="FunCoup" id="Q6FP21">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP21"/>
    <dbReference type="KEGG" id="cgr:2889586"/>
    <dbReference type="CGD" id="CAL0133526">
        <property type="gene designation" value="CAGL0J07282g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07282g"/>
    <dbReference type="eggNOG" id="ENOG502QV98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015198_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP21"/>
    <dbReference type="OMA" id="IPYMSNY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001403">
        <property type="term" value="P:invasive growth in response to glucose limitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007124">
        <property type="term" value="P:pseudohyphal growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF471">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="957" mass="108624" checksum="8FFCF50A2FAC6A91" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP43</accession>
    <name>SPC29_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Spindle pole component 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SPC29</name>
        <name type="ordered locus">CAGL0J06798g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Links the central plaque component SPC42 to the inner plaque component SPC110.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPC29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448001.1">
        <property type="nucleotide sequence ID" value="XM_448001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP43"/>
    <dbReference type="SMR" id="Q6FP43"/>
    <dbReference type="FunCoup" id="Q6FP43">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0J06798g-T">
        <property type="protein sequence ID" value="CAGL0J06798g-T-p1"/>
        <property type="gene ID" value="CAGL0J06798g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889553"/>
    <dbReference type="KEGG" id="cgr:2889553"/>
    <dbReference type="CGD" id="CAL0133364">
        <property type="gene designation" value="CAGL0J06798g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06798g"/>
    <dbReference type="HOGENOM" id="CLU_1277817_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP43"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005823">
        <property type="term" value="C:central plaque of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031392">
        <property type="entry name" value="Spc29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17082">
        <property type="entry name" value="Spc29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000409186" description="Spindle pole component 29">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="234" mass="28043" checksum="46445D9C9E987B3D" modified="2004-07-19" version="1">MVVGPISNLRDDALKDDTLNHIRKEYLESKKQISNLLSQETNTNEFSRKPYPNSSPIRKFDHFANERPTTIDAKLREQLRTGASDVAIEQSLRTNSDESRNQMIYDDMKVMKRIIDGQQESIRELRRALEQERYMNSELQRKYNEMERRFDRLEWFINSHDKFQAYQDIRSNTTKKDFSDPIFNNGLKRRWDEYPIRSFEPDTNINRNNRIFSNYDDSTTRLMQITDPHYRSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPA7</accession>
    <name>Q6FPA7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0J05346g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPA7"/>
    <dbReference type="SMR" id="Q6FPA7"/>
    <dbReference type="FunCoup" id="Q6FPA7">
        <property type="interactions" value="1033"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPA7"/>
    <dbReference type="KEGG" id="cgr:2889510"/>
    <dbReference type="CGD" id="CAL0133120">
        <property type="gene designation" value="CAGL0J05346g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05346g"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005210_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FPA7"/>
    <dbReference type="OMA" id="IFVWGTG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006997">
        <property type="term" value="P:nucleus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00625">
        <property type="entry name" value="RCC1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="39"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="95"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="174"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="230"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="283"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="341"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="422"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0133120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="477" mass="52543" checksum="1D98E7C912D7C77E" modified="2004-07-19" version="1">MVKRSASDEAPTAKRVSTKKVLNQLDDYTHRYISVRPLDVFVWGTGSMCELGLGPLAKNKEVKRPRLNPFLPQDKVGIVSIAVGGMHTLALDKDNNIWSWGCNDYGALGRDTSGAKEKLKDANDSSDDEDGDLNELESTPTKLPFKFEGTSEKDAKIVQLVATDNLSSVLLSDGTIYAWGTFRCNEGILGFYQDEIEVQREPWVVPKFAKGKIVQMAGGKDHILFLDEAGIVYAWGNGQQYQLGRKILDRFRLKTLYPLPFGLKKVKYIASGENHCFALTETGKVVSWGLNQFGQCGIGESIEDGGIVAVPSQVMNLPLDNDSIRTISAGEHHSLFLMESGALYTCGRIDMNEIGLLKKELPTYAYKDEHERVRAVPLPTKVVKTLEELDPEDDEDDREYKEMKFKNIAAGSHHSIAISQDGKLYTWGFGETYAVGQGPAGDDIEVPVKITNTATKEVDMVLAGSGGQFSVSAGYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPI1</accession>
    <name>Q6FPI1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0J03652g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPI1"/>
    <dbReference type="FunCoup" id="Q6FPI1">
        <property type="interactions" value="1269"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPI1"/>
    <dbReference type="KEGG" id="cgr:2889683"/>
    <dbReference type="CGD" id="CAL0133488">
        <property type="gene designation" value="CAGL0J03652g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03652g"/>
    <dbReference type="eggNOG" id="KOG0437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004174_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FPI1"/>
    <dbReference type="OMA" id="KFIEWQF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903432">
        <property type="term" value="P:regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008957">
        <property type="entry name" value="PRK12300.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="54"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="204"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="812"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="13">
        <location>
            <begin position="955"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0133488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1093" mass="124513" checksum="E06FA05E1E0D3274" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPJ9</accession>
    <name>Q6FPJ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0J03234g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPJ9"/>
    <dbReference type="FunCoup" id="Q6FPJ9">
        <property type="interactions" value="1260"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPJ9"/>
    <dbReference type="KEGG" id="cgr:2889732"/>
    <dbReference type="CGD" id="CAL0132956">
        <property type="gene designation" value="CAGL0J03234g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03234g"/>
    <dbReference type="eggNOG" id="KOG3424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107248_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FPJ9"/>
    <dbReference type="OMA" id="IRVKKYM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
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        <property type="term" value="C:fungal biofilm matrix"/>
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        <property type="term" value="C:ribonucleoprotein complex"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:ribosome"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="term" value="P:translation"/>
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        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="eRP_eS24_sf"/>
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        <property type="entry name" value="Ribosomal_eS24"/>
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        <property type="entry name" value="Ribosomal_eS24_CS"/>
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        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
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        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal_S24e"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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            <begin position="105"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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        <source>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0132956"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60794.1"/>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
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    <sequence length="135" mass="15347" checksum="37C8932ED35722EB" modified="2004-07-19" version="1">MSDSVTIRTRKVITNPLLARKQFVVDVLHPNRANVSKDELREKLAEAYKAEKDAVSVFGFRTQFGGGKSTGFGLVYNSVADAKKFEPTYRLVRYGLAEKVEKASRQQRKQKKNRDKKIFGTGRRLAKKVARRNAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2025-06-18" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPQ7</accession>
    <name>PAN1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PAN1</name>
        <name type="ordered locus">CAGL0J01892g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Actin patch</location>
        </subcellularLocation>
        <text evidence="1">Cytoplasmic and cortical actin patches.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PAN1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447787.1">
        <property type="nucleotide sequence ID" value="XM_447787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPQ7"/>
    <dbReference type="SMR" id="Q6FPQ7"/>
    <dbReference type="FunCoup" id="Q6FPQ7">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPQ7"/>
    <dbReference type="EnsemblFungi" id="CAGL0J01892g-T">
        <property type="protein sequence ID" value="CAGL0J01892g-T-p1"/>
        <property type="gene ID" value="CAGL0J01892g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889812"/>
    <dbReference type="KEGG" id="cgr:2889812"/>
    <dbReference type="CGD" id="CAL0133524">
        <property type="gene designation" value="PAN1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01892g"/>
    <dbReference type="eggNOG" id="KOG0998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006042_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPQ7"/>
    <dbReference type="OMA" id="GMPGQWG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990964">
        <property type="term" value="C:actin cytoskeleton-regulatory complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
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    </dbReference>
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        <property type="term" value="P:axial cellular bud site selection"/>
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        <property type="term" value="P:bipolar cellular bud site selection"/>
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    </dbReference>
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        <property type="term" value="P:cell wall organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:reticulophagy"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DUF1720"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF173">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0009">Actin-binding</keyword>
    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0254">Endocytosis</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
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        <location>
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        </location>
    </feature>
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    </feature>
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            <begin position="706"/>
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        <location>
            <begin position="1050"/>
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        <location>
            <begin position="1"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1257"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1299"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1365"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="618"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <sequence length="1374" mass="150836" checksum="659FE29FB5089AF6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPR3</accession>
    <name>Q6FPR3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0J01661g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPR3"/>
    <dbReference type="FunCoup" id="Q6FPR3">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPR3"/>
    <dbReference type="KEGG" id="cgr:2889824"/>
    <dbReference type="CGD" id="CAL0129887">
        <property type="gene designation" value="CAGL0J01661g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01661g"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_1_1"/>
    <dbReference type="InParanoid" id="Q6FPR3"/>
    <dbReference type="OMA" id="YKMSVPK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902557">
        <property type="term" value="F:5'-adenylyl sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="21"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="121"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="232"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0129887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36328" checksum="8E565F15FE135B4A" modified="2004-07-19" version="1">MSEVILPAIEEENQLKNFLKQDTNVAFLAGGIAGAISRTVVSPFERVKILLQVQSSTTAYNKGLFDAIGQVYKEENIKGLFRGNGLNCIRVFPYSAVQFVVFEGCKKHIFHVDTKGKGEQLNNWQRLFSGALCGGCSVVATYPLDLVRTRLSVQTANLSKLSKSRASDIAKPPGVWKLLSKAYAEEGGIMGLYRGVWPTSLGIVPYVALNFAVYEQLKEFMPSDENGNSSMRDSLYKLSMGAISGGVAQTITYPFDLLRRRFQVLAMGGNELGFHYNSVWDALVTIGKTEGFKGYYKGLTANLFKVVPSTAVSWLVYELTWDYMKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPU7</accession>
    <name>Q6FPU7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MAP-homologous protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0J00803g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FPU7">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889868"/>
    <dbReference type="CGD" id="CAL0129791">
        <property type="gene designation" value="CAGL0J00803g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J00803g"/>
    <dbReference type="eggNOG" id="ENOG502QYHN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004492_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FPU7"/>
    <dbReference type="OMA" id="TNTYFND"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052410">
        <property type="entry name" value="DRC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107:SF2">
        <property type="entry name" value="NLR FAMILY CARD DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24107">
        <property type="entry name" value="YNEIN REGULATORY COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="119"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="237"/>
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        </location>
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            <end position="1276"/>
        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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        </source>
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</entry>
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    <accession>Q6FPY1</accession>
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        </recommendedName>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
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                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
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                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
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                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Zeniou-Meyer M."/>
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                <person name="Thierry A."/>
                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPY1"/>
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    </feature>
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        </location>
    </feature>
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    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
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        </recommendedName>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
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                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
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                <person name="Barbe V."/>
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                <person name="Beyne E."/>
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                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
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                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
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            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the SDHAF4 family.</text>
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    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S6UN">
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="CGD" id="CAL0132420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
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    </evidence>
    <sequence length="133" mass="15216" checksum="A22B41A56E5CA437" modified="2004-07-19" version="1">MLRHNRHLFSAVARSSVLISRPVAIRCINTERIPSPPKLPREEQEEFERLQRIAHSQEAIDEYNRKIKGDHTKESLNNEMLTKNDIGSFSPEFSKTIPEFEGDVNPKTGEIGGPKQDPLKHGDYSFNGRVTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQF7</accession>
    <name>Q6FQF7_CANGA</name>
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            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
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        </recommendedName>
    </protein>
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        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
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    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
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                <person name="Durrens P."/>
                <person name="Casaregola S."/>
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                <person name="Aigle M."/>
                <person name="Anthouard V."/>
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                <person name="Barbe V."/>
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                <person name="Beckerich J.M."/>
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                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
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                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447537.1">
        <property type="nucleotide sequence ID" value="XM_447537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQF7"/>
    <dbReference type="FunCoup" id="Q6FQF7">
        <property type="interactions" value="883"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQF7"/>
    <dbReference type="MEROPS" id="C19.004"/>
    <dbReference type="GeneID" id="2889078"/>
    <dbReference type="KEGG" id="cgr:2889078"/>
    <dbReference type="CGD" id="CAL0132468">
        <property type="gene designation" value="UBP3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06600g"/>
    <dbReference type="eggNOG" id="KOG1871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015192_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQF7"/>
    <dbReference type="OMA" id="LDPFQTI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047484">
        <property type="term" value="P:regulation of response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="374"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="439"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0132468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG60474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="816" mass="90995" checksum="6366D546D7147756" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQG2</accession>
    <name>JIP5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>WD repeat-containing protein JIP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">JIP5</name>
        <name type="ordered locus">CAGL0I06490g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447532.1">
        <property type="nucleotide sequence ID" value="XM_447532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQG2"/>
    <dbReference type="SMR" id="Q6FQG2"/>
    <dbReference type="FunCoup" id="Q6FQG2">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQG2"/>
    <dbReference type="EnsemblFungi" id="CAGL0I06490g-T">
        <property type="protein sequence ID" value="CAGL0I06490g-T-p1"/>
        <property type="gene ID" value="CAGL0I06490g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889131"/>
    <dbReference type="KEGG" id="cgr:2889131"/>
    <dbReference type="CGD" id="CAL0132614">
        <property type="gene designation" value="CAGL0I06490g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I06490g"/>
    <dbReference type="eggNOG" id="KOG2444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035623_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQG2"/>
    <dbReference type="OMA" id="DDNCIWC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF31">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN JIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000333553" description="WD repeat-containing protein JIP5">
        <location>
            <begin position="1"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="149"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="193"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="345"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="431"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="508" mass="56378" checksum="B6914C82F9890254" modified="2004-07-19" version="1">MGKKKTSVVQSDELPVIEFRYAEPLFQFVCHPEEPMVVSALATGHVLCHRYDAELLTEKLREARKVQEAVKVEEKKQTLWTVVDVDAADKHPVLPSGVTLLWRTKRHKGSVRALAIDHDGKHVYTIGADNVLKKADTHSGKVVKKVTLDGGSKVTKLVKSATHDFLVMGDEVGTIVVLDSNDLTTKNTLTKIHGGDAINDIFQFCKRSVYKYISLGQTTLAYWDTREPKMKQPKKNSGNQTEEELSNIMCSDDQEDEILCGAFVDPIEGDTLVCGMGEGTLTVWKPKKNDLEDQLTRVKIAKGESIDTVISTLQDDNCVWCGCSNGLLYKVDTKRGKIVEIRKHSGLDEVGMLDLDFEYRLVSGGMDKLKIWEVPKEENSDSDSDSDINDDSEAGLSSSEDSDSDSELGSGSESEVESDASSKSDSDLEECTGSDLPGDIEGSEGENNSNDDDNHDDREELWKELDQPTSDEEEPPKKRSLKVKDKKNKKFKKNENNLSHGITKFDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR69</accession>
    <name>Q6FR69_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione hydrolase</fullName>
            <ecNumber evidence="8">2.3.2.2</ecNumber>
            <ecNumber evidence="8">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0I00506g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="8"/>
    <dbReference type="EC" id="3.4.19.13" evidence="8"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR69"/>
    <dbReference type="FunCoup" id="Q6FR69">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR69"/>
    <dbReference type="MEROPS" id="T03.012"/>
    <dbReference type="KEGG" id="cgr:2889319"/>
    <dbReference type="CGD" id="CAL0132680">
        <property type="gene designation" value="CAGL0I00506g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00506g"/>
    <dbReference type="eggNOG" id="KOG2410">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014813_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FR69"/>
    <dbReference type="OMA" id="ICGMGPP"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF9">
        <property type="entry name" value="RE13973P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273425" description="Glutathione hydrolase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="449"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="501"/>
            <end position="502"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0132680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG60212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="621" mass="68857" checksum="E744385EE345AB95" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRD2</accession>
    <name>Q6FRD2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 13">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0H09504g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 13"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRD2"/>
    <dbReference type="FunCoup" id="Q6FRD2">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRD2"/>
    <dbReference type="KEGG" id="cgr:2888612"/>
    <dbReference type="CGD" id="CAL0131622">
        <property type="gene designation" value="CAGL0H09504g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09504g"/>
    <dbReference type="eggNOG" id="KOG1276">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009629_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FRD2"/>
    <dbReference type="OMA" id="EHNQAVQ"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000276">
        <property type="entry name" value="Protoporphyrinogen oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0274">FAD</keyword>
    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 13" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10 13" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0131622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="538" mass="59620" checksum="9E6093C4DEE20F10" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRD8</accession>
    <name>Q6FRD8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0H09372g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRD8"/>
    <dbReference type="FunCoup" id="Q6FRD8">
        <property type="interactions" value="850"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRD8"/>
    <dbReference type="KEGG" id="cgr:2888727"/>
    <dbReference type="CGD" id="CAL0131502">
        <property type="gene designation" value="CAGL0H09372g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09372g"/>
    <dbReference type="eggNOG" id="KOG2144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035267_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FRD8"/>
    <dbReference type="OMA" id="RKIHMLA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990825">
        <property type="term" value="F:sequence-specific mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="345"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0131502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="392" mass="43975" checksum="AC9D3D9BDCE44EA7" modified="2004-07-19" version="1">MDAEEQYEWITKNLQEVLNPQIIKDVLKEGRPLKLYWGTAPTGRPHCGYFVAMTKLAHFLKAGVEVTVLLADLHAFLDNMKAPLEVVNYRTKYYEYTVKAILKSINVPIEKLKFVVGSSYQLGGDYTLDLFKLSNMVSQNDAKRAGADVVKQVANPLLSGLIYPLMQALDEQFLDVDVQFGGVDQRKIFVLAEENLPRIGYKKRAHLMNPMVPGLTQGGKMSASDPNSKIDLLEEPKKVGKKINSAYCSPGDIENNGLLSFVEYVIEPIQELKKGTGKFEFFINRPEKFGGPVTYTSFKDLQTAFKEQQLMPVDLKIGVTDAINELLAPIREEFANSKEYQEAEAKGYPQVVPEKTKKVKKPKNKGTRYPGATKTEEPKVEAVTEELKEASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRG4</accession>
    <name>Q6FRG4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0H08778g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRG4"/>
    <dbReference type="STRING" id="284593.Q6FRG4"/>
    <dbReference type="KEGG" id="cgr:2888724"/>
    <dbReference type="CGD" id="CAL0132042">
        <property type="gene designation" value="CAGL0H08778g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08778g"/>
    <dbReference type="eggNOG" id="KOG4574">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009728_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRG4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052645">
        <property type="entry name" value="Pumilio_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47093:SF1">
        <property type="entry name" value="PROTEIN JSN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="356"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="PUM-HD" evidence="6">
        <location>
            <begin position="554"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="619"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0132042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG60113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118277" checksum="4888EDEE757E4B28" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRI4</accession>
    <name>Q6FRI4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Broad-range acid phosphatase DET1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H08305g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRI4"/>
    <dbReference type="FunCoup" id="Q6FRI4">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRI4"/>
    <dbReference type="KEGG" id="cgr:2888856"/>
    <dbReference type="CGD" id="CAL0131688">
        <property type="gene designation" value="CAGL0H08305g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H08305g"/>
    <dbReference type="eggNOG" id="ENOG502QQ8J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_3_3_1"/>
    <dbReference type="InParanoid" id="Q6FRI4"/>
    <dbReference type="OMA" id="MRLFCMR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052765">
        <property type="entry name" value="PGM-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46192">
        <property type="entry name" value="BROAD-RANGE ACID PHOSPHATASE DET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="37438" checksum="C5D82ABAA71EEECE" modified="2004-07-19" version="1">MVDSYNRPRLIVLIRHGESESNKDKKINEVTPNHLIPLTPYGKKQAHNAGLKLLRLLNMADASVIEKLGEEYALPATSTNTLELRGYKPNGKHMDDNIIFYTSPYKRTRETLKGVLEVIDRYNELKSGINMCAEQTYNPYGKQKHAIWPHDLENSGIYENDESTHCGPEREGTYIRYRIIDEPRLREQDFGNYQEVSSMQDVMEKRKTYGHFFFRFPEGESAADVYDRVASFQDTLYRHFQFRQHTKGRDVVVLVTHGIYSRVFLMKWFRWTFEEFESFTNVPNGSLMVMELDEKLNKYVLRTVLPKWSDLEAEKDLIT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-11-02" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRU5</accession>
    <name>INA17_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Inner membrane assembly complex subunit 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">INA17</name>
        <name type="ordered locus">CAGL0H05819g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the INA complex (INAC) that promotes the biogenesis of mitochondrial F(1)F(0)-ATP synthase. INAC facilitates the assembly of the peripheral stalk and promotes the assembly of the catalytic F(1)-domain with the membrane-embedded F(0)-domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the inner membrane assembly (INA) complex, composed of INA17 and INA22. Interacts with a subset of F(1)F(0)-ATP synthase subunits of the F(1)-domain and the peripheral stalk.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INA17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447049.1">
        <property type="nucleotide sequence ID" value="XM_447049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRU5"/>
    <dbReference type="FunCoup" id="Q6FRU5">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0H05819g-T">
        <property type="protein sequence ID" value="CAGL0H05819g-T-p1"/>
        <property type="gene ID" value="CAGL0H05819g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888642"/>
    <dbReference type="KEGG" id="cgr:2888642"/>
    <dbReference type="CGD" id="CAL0131788">
        <property type="gene designation" value="CAGL0H05819g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05819g"/>
    <dbReference type="eggNOG" id="ENOG502S3U1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127263_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FRU5"/>
    <dbReference type="OMA" id="HYVWWKL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990524">
        <property type="term" value="C:INA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990677">
        <property type="term" value="C:mitochondrial inner membrane assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000399878" description="Inner membrane assembly complex subunit 17" evidence="2">
        <location>
            <begin position="29"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="1">
        <location>
            <begin position="29"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="1">
        <location>
            <begin position="119"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="Q02888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="164" mass="19359" checksum="F60CE52B7C4ADE85" modified="2004-07-19" version="1" precursor="true">MIKTAKISTLRLAITRNARNLSFTTLVRSPEVDNSKIKTLEDLTRLETLEGVDPELIKRLINEKTQEFNTQDELKLLKSMQMEQDRLNEVPLKRFTRPLWIFILMASTFYLGAHLVWWKLAYEKKEVELKHKVDSLETTLKDVMKEKATGPTPCNNKKSWYKFW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRX4</accession>
    <name>TIM50_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TIM50</name>
        <name type="ordered locus">CAGL0H05159g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts with preproteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447020.1">
        <property type="nucleotide sequence ID" value="XM_447020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRX4"/>
    <dbReference type="SMR" id="Q6FRX4"/>
    <dbReference type="FunCoup" id="Q6FRX4">
        <property type="interactions" value="508"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRX4"/>
    <dbReference type="EnsemblFungi" id="CAGL0H05159g-T">
        <property type="protein sequence ID" value="CAGL0H05159g-T-p1"/>
        <property type="gene ID" value="CAGL0H05159g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888680"/>
    <dbReference type="KEGG" id="cgr:2888680"/>
    <dbReference type="CGD" id="CAL0130595">
        <property type="gene designation" value="CAGL0H05159g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05159g"/>
    <dbReference type="eggNOG" id="KOG2832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023309_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FRX4"/>
    <dbReference type="OMA" id="NLRQPYT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046902">
        <property type="term" value="P:regulation of mitochondrial membrane permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000043128" description="Mitochondrial import inner membrane translocase subunit TIM50">
        <location>
            <begin position="36"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial matrix" evidence="2">
        <location>
            <begin position="36"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="topological domain" description="Mitochondrial intermembrane" evidence="2">
        <location>
            <begin position="138"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="193"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="485" mass="57154" checksum="1788E9590739B623" modified="2004-07-19" version="1" precursor="true">MLSLFRCAVTRAPHIASKGISVQISRNLANSLIVQNKRRLNTKSYFLQEQKKDDKKAQSILTDDLLFKAGIDVEEGKKEGQQKQHETEEGNEEQQSENSSNKKRKRRMTSADKKKERYANYFYIFTFSSLAGLGLYMCRDWEENEDDEMKKDIDNGYTPDLMYKRFRARFNSVFTYFQEPPFPDLLPPPPPAPYQRPLTLVITLEDFLVHSEWDQKHGWRTAKRPGADYFLGYLSQYYEIVLFSSNYMMYAEKIAEKMDPIHAFISYNLFKEHCVYKDGVHIKDLSKLNRDLKKVMIIDTDENSYKLQPENAIPMDPWDGKADDKLLRLIPFLEYMATQQVEDVRPILKSYHNKRELPAEFEQRVQKLKNKFEQDQKKKNDSNWLLKLLGLAPVINGIGGGNKFPLDMIREEGEKNYVRFMKLIEEEKEKMRIQQEQMSGQTFTLKDYVEGNIPTPEEQMKMQLEKQKEIDALFEQKKKEQQANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS21</accession>
    <name>Q6FS21_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0H04103g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS21"/>
    <dbReference type="FunCoup" id="Q6FS21">
        <property type="interactions" value="112"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS21"/>
    <dbReference type="KEGG" id="cgr:2888830"/>
    <dbReference type="CGD" id="CAL0131560">
        <property type="gene designation" value="CAGL0H04103g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H04103g"/>
    <dbReference type="eggNOG" id="KOG0274">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_425266_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS21"/>
    <dbReference type="OMA" id="CTTPQGC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071406">
        <property type="term" value="P:cellular response to methylmercury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052301">
        <property type="entry name" value="SCF_F-box/WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381">
        <property type="entry name" value="DACTYLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14381:SF1">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="667" mass="76466" checksum="0CF425A4A49E0D09" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-09-27" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS31</accession>
    <name>RM02_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>54S ribosomal protein L2, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">MRPL2</name>
        <name type="ordered locus">CAGL0H03883g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the large subunit of mitochondrial ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS31"/>
    <dbReference type="SMR" id="Q6FS31"/>
    <dbReference type="FunCoup" id="Q6FS31">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS31"/>
    <dbReference type="EnsemblFungi" id="CAGL0H03883g-T">
        <property type="protein sequence ID" value="CAGL0H03883g-T-p1"/>
        <property type="gene ID" value="CAGL0H03883g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888661"/>
    <dbReference type="CGD" id="CAL0130078">
        <property type="gene designation" value="CAGL0H03883g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03883g"/>
    <dbReference type="eggNOG" id="KOG4600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063752_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS31"/>
    <dbReference type="OMA" id="YLDPFHP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041244">
        <property type="entry name" value="Ribosomal_bL27m_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18471">
        <property type="entry name" value="Ribosomal_L27_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0809">Transit peptide</keyword>
    <feature type="transit peptide" description="Mitochondrion" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000030498" description="Large ribosomal subunit protein bL27m">
        <location>
            <begin position="21"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="368" mass="43147" checksum="87DF9DC9DCED086C" modified="2004-07-19" version="1" precursor="true">MFSGLHTSKYACQVVVQIRTATKRAAGSRTSMKDSAGRRLGPKKYEGQDVKPGEIIMRQRGTKFYPGENVKIGRDHTIYAVEPGVVRYYLDPFHPYRKFIGVALSRDMKLPKPHFEPNVRRFGRIELDNPKAIAKEENALSRKEYLSRDTLLKDLTEREAKRHEMMDNYWNFISSELKLNIIPERKEMASNYLLRYRTGLKNGFDLQEAQFNAKYYLQQMLKLKAKRKEWNEEKLSEQLHNLDETTALLNKSVSFSNKWVIIPYISEEEKLTRKDELIKKLTELGTAIKSKSDKKAVLELFKDASHFLTQAQEVRLRRQFMKPVQPEIMNVNVAEKADKKTTVIRRFNYEKSKIDIIPRTKTAFFKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS40</accession>
    <name>Q6FS40_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0H03685g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS40"/>
    <dbReference type="FunCoup" id="Q6FS40">
        <property type="interactions" value="1712"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS40"/>
    <dbReference type="KEGG" id="cgr:2888607"/>
    <dbReference type="CGD" id="CAL0131870">
        <property type="gene designation" value="CAGL0H03685g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03685g"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_3_2_1"/>
    <dbReference type="InParanoid" id="Q6FS40"/>
    <dbReference type="OMA" id="KYGRTNE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="10">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="9">
        <location>
            <begin position="266"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0131870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG59887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="474" mass="53853" checksum="58F375DE084993E9" modified="2004-07-19" version="1">MSEEHIIKPETTSPSTNASEWPLLLKDYDKLLVRSGHYTPIPAGSSPLKRDLKSYISSGVINLDKPSNPSSHEVVAWIKRILRCEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCIVRLHDALKDEKDLGRSLENLTGALFQRPPLISAVKRQLRVRTIYDSNLIEFDNKRNLGVFWASCEAGTYMRTLCVHLGMLLGVGGHMQELRRVRSGALSENDNMVTLHDVLDAQWVFDNTRDESYLRKIIQPLETLLVGYKRIVVKDSAVNAVCYGAKLMIPGLLRYEEGIELYDEVVLMTTKGEAIAVAIAQMSTVDLATCDHGVVATVKRCIMERDLYPRRWGLGPIAQKKKQLKADGKLDKYGRVNESTPEDWKKSYVPLDKSEASESSSDAKKVEEQVKEEVEEPKKEEKEDEKEDEEPKKEKKEKKEKKEKKEKKEKKEKKEKKEKKRKAEDEGEEKKKKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS49</accession>
    <name>Q6FS49_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AFT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AFT1</name>
        <name evidence="1 2" type="ordered locus">CAGL0H03487g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446945.1">
        <property type="nucleotide sequence ID" value="XM_446945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS49"/>
    <dbReference type="SMR" id="Q6FS49"/>
    <dbReference type="FunCoup" id="Q6FS49">
        <property type="interactions" value="1208"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS49"/>
    <dbReference type="GeneID" id="2888849"/>
    <dbReference type="KEGG" id="cgr:2888849"/>
    <dbReference type="CGD" id="CAL0129667">
        <property type="gene designation" value="AFT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03487g"/>
    <dbReference type="eggNOG" id="KOG4818">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508972_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS49"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032048">
        <property type="term" value="P:cardiolipin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034087">
        <property type="term" value="P:establishment of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034758">
        <property type="term" value="P:positive regulation of iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014842">
        <property type="entry name" value="AFT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08731">
        <property type="entry name" value="AFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0129667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60642" checksum="9598B8A63D726B29" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSA8</accession>
    <name>Q6FSA8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0H02101g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSA8"/>
    <dbReference type="FunCoup" id="Q6FSA8">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSA8"/>
    <dbReference type="KEGG" id="cgr:2888701"/>
    <dbReference type="CGD" id="CAL0131668">
        <property type="gene designation" value="CAGL0H02101g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02101g"/>
    <dbReference type="eggNOG" id="ENOG502S9SB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137480_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FSA8"/>
    <dbReference type="OMA" id="HYKGKDD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="129" mass="14214" checksum="CAF10A9F481CDC0A" modified="2004-07-19" version="1">MSLNELFHGNQHDDTKKKPRRNSSTEVLQYFYKGKETDLVIYVTSQAAADDYLASPSPSKLANVVEVFKVFTNLDGKGATGTFGEASKAQLENEFGKGKKVEEVIGLILKEGVPNGKTNRVKTEGNFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSB6</accession>
    <name>Q6FSB6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">CAGL0H01815g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSB6"/>
    <dbReference type="STRING" id="284593.Q6FSB6"/>
    <dbReference type="KEGG" id="cgr:2888870"/>
    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_619624_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSB6"/>
    <dbReference type="OMA" id="HEENMES"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="280"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="442" mass="51508" checksum="DD1D30EFCBC8DAA5" modified="2004-07-19" version="1">MERSNRSRKSRRQEVSEDILERELKQYVNSSERMHESDAVERSPKRRKGSHREVDIETTVHTTVHYDEKEEVNGSDLNDDEQRRAIEGAASEDETHAVEGEHEDEDERENHVNDHDDNRDPNVDDELHRADADHQEHDEEDRDEDQHQHQHQEQEQEQEQGHEPEHEQEQEAEHEQEPEQEQGQEPEEEHGHEHDHEENMESIREIANDSGDAAAAVSTIRIHYQDLSGNSRGDTTINVGPENPELYASLSSRSDVKTENKKKRGKQTKGDESIQDWRKIRKESHKEVERRRRETINLAIDNLRKLLPKPEYSKAGILNSAAALIQKLKESESSQMNKWAIQRIVTEQTKTAHQKSNEKLAAALDDAYQELTRLKSILKENNIKYEDKFVIPEDTLREAKELESELNRAQEEIDQIDPRASAEPEEEEEERDEEAGEDESKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSE0</accession>
    <name>Q6FSE0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SSD1</name>
        <name evidence="5 6" type="ordered locus">CAGL0H01287g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446854.1">
        <property type="nucleotide sequence ID" value="XM_446854.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q6FSE0"/>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="10">Transcription factor IIIA</fullName>
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        <name evidence="14 15" type="ordered locus">CAGL0G10021g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0129918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG59723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="394" mass="45716" checksum="130E6160E5FCF799" modified="2004-07-19" version="1">MEANDVFDSQVPLSRSSSVGSMSSVASGSSVRSKTYLCEYDNCDKAFTRPSLLTEHQNTVHLGRKPWKCNQCESSFTKKIHLERHLYTHTDERPFYCSFCGKGLITRQQLKRHEVTHTKSFNCEYEGCNESFYKHPQLRAHILAVHLQSLKCHECNKSFQRPYRLKNHIAKHHNPDVVNAYQCTFSVCSKSFKTWSALRLHVKNDHPKLKCPICSKPCVGEDGLNMHMKIHDENLVSRNWKCHICNDQSFAKKLELLDHYSNSHSEEIPAYLLEQKVVPYVETNVTGKTECEKSPTKKYVKATDMLAIRTETNLNRFFDGGKDAMTLLLNTVGRKFRCPYSKCYRSFKTEEKYNIHIEKHRIHEQKLKELETSGQLQMADIEPDRQSTALEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT73</accession>
    <name>Q6FT73_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SUR4</name>
        <name evidence="12 13" type="ordered locus">CAGL0G04851g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT73"/>
    <dbReference type="FunCoup" id="Q6FT73">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT73"/>
    <dbReference type="KEGG" id="cgr:2888002"/>
    <dbReference type="CGD" id="CAL0129908">
        <property type="gene designation" value="SUR4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04851g"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_6_1_1"/>
    <dbReference type="InParanoid" id="Q6FT73"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF157">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0129908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="366" mass="41202" checksum="29E7E159FF08BB76" modified="2004-07-19" version="1">MDQPVSQVTSAVASGAASAATAASSAAATAASVAVDQLEVLFQGAPSWIKVHTPSIDHPFGLELWPLFSAVFEKIAGYPAEDFRFIYNETFLANGYQAIGIIIFYYIVIFGGQAILRAINASPMHFHFLFQLHNLFLTSISFILMVLLIEQLVPMIYHHGLFWAICSPQAFAPKLVVLYYLNYLTKFVELFDTVFLIFKRKKLLFLHTYHHGATALLCYTQLVGETSVEWVPIVLNLGVHVVMYWYYFLSSCGIRVWWKQWVTRFQIIQFLIDLVFVYFATYTFYANKYFDGILPNKGTCYGTQDAAAYGYLILTSYLVLFISFYINSYKKGSKKKAEKEAEKAAAASATSSAVKTKSSKPSSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT83</accession>
    <name>Q6FT83_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADIPOR-like receptor IZH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0G04631g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT83"/>
    <dbReference type="FunCoup" id="Q6FT83">
        <property type="interactions" value="280"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT83"/>
    <dbReference type="KEGG" id="cgr:2888024"/>
    <dbReference type="CGD" id="CAL0130225">
        <property type="gene designation" value="CAGL0G04631g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04631g"/>
    <dbReference type="eggNOG" id="KOG0748">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023075_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FT83"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF95">
        <property type="entry name" value="ADIPOR-LIKE RECEPTOR IZH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0130225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35730" checksum="BC3BF6325205E656" modified="2004-07-19" version="1">MSATTTLRKRASKSVGESGGRNDGSIHAHGEEKSEKLLWHFNELPEWQKDNDKILRGYVRETNSFKRCLQSLLYLNNESVNIYTHLIPAVFYISLSLYLANVFLIPVYPSTSSVDYVIINVFFLGAFFCLLCSSCFHCMKQHSESQCNVWSKLDYLGIICLISCSTVPMIYYGYFDHISEFTIFTGITLLLAIGCSVFVLTDKFNTTEYRPIRASFFTLFGFSGIIPLGAGFLKFGAEGVLQRISLPFIGLEALFYISGAIIYGFRFPETIAPGKFDFFGSSHQIFHIMVVLGSICHLFAMVESYHLIHSNFLRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTD6</accession>
    <name>Q6FTD6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of Ty1 transposition protein 105</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G03333g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTD6"/>
    <dbReference type="FunCoup" id="Q6FTD6">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888005"/>
    <dbReference type="CGD" id="CAL0137609">
        <property type="gene designation" value="CAGL0G03333g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G03333g"/>
    <dbReference type="eggNOG" id="ENOG502S9AV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1454195_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTD6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21280" checksum="33B19521D24FFA13" modified="2004-07-19" version="1">MSESIDQESDLSFHTAIEEPFTSLTSTPHKSSNGWVSYPTNEGKDSTNSSSPNLGNESIVNDIISRRRNASSGPANNLSQSARRDTENKKLKELRRLKRLQKTIKNRGGLDNMRDFVLNSEIDAEYARLAKEAEQFALPIDELERIEKQTEEDLDDDEILEFIEQRDKYQYELDQILNENIAKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTF7</accession>
    <name>Q6FTF7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ULP1-interacting protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0G02849g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTF7"/>
    <dbReference type="FunCoup" id="Q6FTF7">
        <property type="interactions" value="67"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTF7"/>
    <dbReference type="KEGG" id="cgr:2888355"/>
    <dbReference type="CGD" id="CAL0130115">
        <property type="gene designation" value="CAGL0G02849g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G02849g"/>
    <dbReference type="eggNOG" id="ENOG502SASQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079707_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTF7"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0130115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25958" checksum="18A21C2D6EFC6A5F" modified="2004-07-19" version="1">MVAIIYRHKAKEFNELKIAGGFNNWEIVPMQWSPAKEQWEYELDLEKIPAAVTKIHFKFIDDQGNWFTDSNYAKEIDEHNNENNVKLLPGHQETATASDDKDVSYQDEQLEKGPITPAPSLVAEKTSEKHTTTEDPKPVPEALPEVTETIVEEPAKALTDEEDTANSSEEQTRVEEEEPEQIEEVTDTNETKNTVIKGSDADMYKTLLQKIIEFFVSWFAWIRGDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTM4</accession>
    <name>Q6FTM4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar segregation protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0G01342g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
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    <sequence length="770" mass="86667" checksum="AB62B5CC6A22E10B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTY0</accession>
    <name>Q6FTY0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0F07953g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTY0"/>
    <dbReference type="FunCoup" id="Q6FTY0">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887609"/>
    <dbReference type="CGD" id="CAL0129357">
        <property type="gene designation" value="CAGL0F07953g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07953g"/>
    <dbReference type="eggNOG" id="ENOG502SCND">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183906_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FTY0"/>
    <dbReference type="OMA" id="ENIAHKP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0129357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="96" mass="11132" checksum="C68AAD5ED9F25C23" modified="2004-07-19" version="1">MQINPRIYSEAQKVAKQPQFKYLVAAMLCAAMVPTAYRRGVTLPHYSQSVLEEVNENIAHKPIEKEKNPSMWGMLKDANKYDLNEEYTYELFSSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTY6</accession>
    <name>Q6FTY6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0F07821g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTY6"/>
    <dbReference type="FunCoup" id="Q6FTY6">
        <property type="interactions" value="461"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTY6"/>
    <dbReference type="KEGG" id="cgr:2887921"/>
    <dbReference type="CGD" id="CAL0129344">
        <property type="gene designation" value="CAGL0F07821g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07821g"/>
    <dbReference type="eggNOG" id="KOG0942">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002173_2_3_1"/>
    <dbReference type="InParanoid" id="Q6FTY6"/>
    <dbReference type="OMA" id="IIAPHWM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071629">
        <property type="term" value="P:cytoplasm protein quality control by the ubiquitin-proteasome system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010994">
        <property type="term" value="P:free ubiquitin chain polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000011">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="584"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0129344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="921" mass="106632" checksum="613A62E60264DCD8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU19</accession>
    <name>MON1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Vacuolar fusion protein MON1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MON1</name>
        <name type="ordered locus">CAGL0F07051g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
            <location evidence="1">Multivesicular body membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MON1/SAND family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446275.1">
        <property type="nucleotide sequence ID" value="XM_446275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU19"/>
    <dbReference type="SMR" id="Q6FU19"/>
    <dbReference type="FunCoup" id="Q6FU19">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU19"/>
    <dbReference type="EnsemblFungi" id="CAGL0F07051g-T">
        <property type="protein sequence ID" value="CAGL0F07051g-T-p1"/>
        <property type="gene ID" value="CAGL0F07051g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887661"/>
    <dbReference type="KEGG" id="cgr:2887661"/>
    <dbReference type="CGD" id="CAL0129189">
        <property type="gene designation" value="CAGL0F07051g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F07051g"/>
    <dbReference type="eggNOG" id="KOG0997">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014574_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU19"/>
    <dbReference type="OMA" id="YTHIRNN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990624">
        <property type="term" value="F:guanyl nucleotide exchange factor inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010314">
        <property type="term" value="F:phosphatidylinositol-5-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044395">
        <property type="term" value="P:protein targeting to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043970">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19038">
        <property type="entry name" value="Fuz_longin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000278857" description="Vacuolar fusion protein MON1">
        <location>
            <begin position="1"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P53129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="597" mass="68276" checksum="E22263AC3DD4FF6F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU30</accession>
    <name>Q6FU30_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0F06809g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU30"/>
    <dbReference type="FunCoup" id="Q6FU30">
        <property type="interactions" value="797"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU30"/>
    <dbReference type="KEGG" id="cgr:2887933"/>
    <dbReference type="CGD" id="CAL0131296">
        <property type="gene designation" value="CAGL0F06809g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F06809g"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023312_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FU30"/>
    <dbReference type="OMA" id="FAWQGMQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000116">
        <property type="entry name" value="YVH1p Protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="86"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0131296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG59188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="361" mass="41409" checksum="DBB7872DFAE69A87" modified="2004-07-19" version="1">MEVTRVLGGIYMGGFTPLANHTPLKAEYNITHILSVIKLDTIPEYLVRKGYTLKSIPIDDDDTTDILQYFNESNKFLDHCLYPYEQEYDPALVDFRKKKQDPQNAVYVHCQAGISRSTSFVVAYLMYRFGLRLKDALHAVRRKRPQVEPNPNFMEQLQVYAEMGANRVDPDNQLYKTWKLAQSIKVDPTGRDILSKDDTYKDSSNEDQELDKLTKEELSQTTVIRCKNCRKRLALSTSFIKHDPPSKQSSEGHFIRRAAGSRRIIDIQESSTTCSHFFVEPLNWMKQELQGKQELEGKFSCPGCSYKVGGYNWKGSRCSCGKWVIPAIHLQSSKVDHFPLAERTLPNMVNFKPSNVPLPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUF4</accession>
    <name>Q6FUF4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SKY1</name>
        <name evidence="12 13" type="ordered locus">CAGL0F03905g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446140.1">
        <property type="nucleotide sequence ID" value="XM_446140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUF4"/>
    <dbReference type="FunCoup" id="Q6FUF4">
        <property type="interactions" value="599"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUF4"/>
    <dbReference type="GeneID" id="2887770"/>
    <dbReference type="KEGG" id="cgr:2887770"/>
    <dbReference type="CGD" id="CAL0129366">
        <property type="gene designation" value="SKY1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03905g"/>
    <dbReference type="eggNOG" id="KOG1290">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_81_12_1"/>
    <dbReference type="InParanoid" id="Q6FUF4"/>
    <dbReference type="OMA" id="NHKGPNG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042307">
        <property type="term" value="P:positive regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035617">
        <property type="term" value="P:stress granule disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000591">
        <property type="entry name" value="Serine protein kinase Sky1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="163"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0129366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="708" mass="78825" checksum="58E22744522CD348" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUQ8</accession>
    <name>Q6FUQ8_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TIR2</name>
        <name evidence="3 4" type="ordered locus">CAGL0F01485g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446036.1">
        <property type="nucleotide sequence ID" value="XM_446036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUQ8"/>
    <dbReference type="STRING" id="284593.Q6FUQ8"/>
    <dbReference type="GeneID" id="2887690"/>
    <dbReference type="KEGG" id="cgr:2887690"/>
    <dbReference type="CGD" id="CAL0130970">
        <property type="gene designation" value="TIR2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01485g"/>
    <dbReference type="HOGENOM" id="CLU_071083_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUQ8"/>
    <dbReference type="OMA" id="DEECHKS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000992">
        <property type="entry name" value="SRP1_TIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050788">
        <property type="entry name" value="Yeast_SRP1/TIP1_CWP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002:SF34">
        <property type="entry name" value="CELL WALL PROTEIN CWP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31002">
        <property type="entry name" value="SERIPAUPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00660">
        <property type="entry name" value="SRP1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00724">
        <property type="entry name" value="SRP1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274880" evidence="2">
        <location>
            <begin position="19"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0130970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="337" mass="33975" checksum="3B1E926D699DBE8C" modified="2004-07-19" version="1">MKFSTVAPLAFAAAVAHASNPTPMQLAELNAVMEDLKTNLQDYMNLAMDPNSGFSLADMPSGLIQLGMAVGTATDDSYTSMYSDVDFAGVDKMVTMVPWYSSRLKPLIDSLYAAENPAPSTSSASQATPAPAASSSAAPAAGSSTPAPAPVSSAAPSSYAPAPMVNSTMPMANGTTTQTTTHLSTKTSTICDEECHKSMSTATAFKNVTDTQTTTYCPESSLFKNGTSTVTNMHTTTSTVCETCISKPATSSAKPATSAKPASSAKPAVSSAKPAVTSAKSSAGKTTVTTSTIKVSLTSSKAAAPSSVVIQHQTVNGAAKVAAGMGAGVLAAAALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUR2</accession>
    <name>Q6FUR2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0F01397g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUR2"/>
    <dbReference type="FunCoup" id="Q6FUR2">
        <property type="interactions" value="751"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUR2"/>
    <dbReference type="KEGG" id="cgr:2887953"/>
    <dbReference type="CGD" id="CAL0131390">
        <property type="gene designation" value="CAGL0F01397g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F01397g"/>
    <dbReference type="eggNOG" id="KOG2085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012437_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FUR2"/>
    <dbReference type="OMA" id="MYAHVVN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032186">
        <property type="term" value="P:cellular bud neck septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070199">
        <property type="term" value="P:establishment of protein localization to chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031107">
        <property type="term" value="P:septin ring disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031134">
        <property type="term" value="P:sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="679"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="679"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0131390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="729" mass="82384" checksum="0DDFB3567DE3754F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUU6</accession>
    <name>Q6FUU6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0F00561g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG58922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUU6"/>
    <dbReference type="FunCoup" id="Q6FUU6">
        <property type="interactions" value="741"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUU6"/>
    <dbReference type="KEGG" id="cgr:2887783"/>
    <dbReference type="CGD" id="CAL0131128">
        <property type="gene designation" value="CAGL0F00561g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F00561g"/>
    <dbReference type="eggNOG" id="KOG2907">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093932_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FUU6"/>
    <dbReference type="OMA" id="EMQYHTL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="85"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0131128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG58922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="128" mass="14444" checksum="08FD43FD622A9D22" modified="2004-07-19" version="1">MSAVGSLIFCDDCGNLLDNPEDKINNSNVIECSQCQAEYAKSQFTNLKVVTSTSEDAFPSSLRLKRSVVKTHLKRDELKDDGATIKEKCPKCGHDEMRYQTLQLRSADEGATVFYTCIKCNYKYRTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUZ4</accession>
    <name>Q6FUZ4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0E06006g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial metal transporter involved in mitochondrial iron accumulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUZ4"/>
    <dbReference type="STRING" id="284593.Q6FUZ4"/>
    <dbReference type="KEGG" id="cgr:2887415"/>
    <dbReference type="CGD" id="CAL0128720">
        <property type="gene designation" value="CAGL0E06006g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06006g"/>
    <dbReference type="eggNOG" id="KOG1485">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_12_2_1"/>
    <dbReference type="InParanoid" id="Q6FUZ4"/>
    <dbReference type="OMA" id="YFLNIYW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0409">Iron storage</keyword>
    <keyword evidence="5" id="KW-0410">Iron transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="12">
        <location>
            <begin position="99"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0128720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG58869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="411" mass="44874" checksum="4E2B1C656ABB3BAB" modified="2004-07-19" version="1">MSMIRARLTLNKRLNATLICQPYKRLLHSSRAIAHQHKDQEQIPDHEHNHDPTIEEHGLKSMLSHSHSHGHSHSHSGENAFLTLSKDNVLTNPGVRITWIGLGSNVLMAVGKFFGGIAFHSQALLADSVHAMSDLVSDFLTLFSVSLSSKKSNDMYPYGYGKVETVGSLAVSTILAGAGVSIGWSSLCAIVGPIVPHTIIESLHNIFGSMIDFSGSHSHSHTSATDVNAAWIAGGSIIMKEWIFQATKRVAIKTNSNVLMANAWHHRIDSLTSLVALVAISSSYFFGIQSLDSLGGLLVSVLIIKAGGEGMVSSVKELTDQSLSKKDERYLEIESILKKQIPLLDRGNLELDRLVVMPSGPKMRAITTLSVPQDSNISVHDMDNVTAELRKSMLDGVKNLSFFDVRYTSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FV42</accession>
    <name>Q6FV42_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0E04928g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FV42"/>
    <dbReference type="FunCoup" id="Q6FV42">
        <property type="interactions" value="751"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FV42"/>
    <dbReference type="KEGG" id="cgr:2887343"/>
    <dbReference type="CGD" id="CAL0128718">
        <property type="gene designation" value="CAGL0E04928g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E04928g"/>
    <dbReference type="eggNOG" id="KOG2726">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_4_1"/>
    <dbReference type="InParanoid" id="Q6FV42"/>
    <dbReference type="OMA" id="DHRVGFK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0128718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="405" mass="46106" checksum="B70475537883A7B3" modified="2004-07-19" version="1">MWIARNNLKVLSRARIPVWRAYRFASTAASEADEEALEFQELNPLLLKRVSGVSKELAELEKQISNGYDEDVQRKYNSLMSLQDVYDRYKEQLGNYRELKEMIDVDKSLAEEAAAELHELVPNLKKTTQDLLHRLIPPHPFAEKACMLELRPGVGGSEAMIFAKDLLNMYIGYAHNKKWKHHIVSIRENEAGSGIMDAVLAIDEPGTYNILKYEAGVHRVQRIPATESKGRTHTSTAAVVVLPQLGDEGKDLDAFERSFKPEEIRIDVKRASGKGGQHVNTTESAVRLTHIPTGIMIHMQDERSQHRNKAKAFSILRSKLAELEQQQKAEKERQVRKEQVTTMDRSDKIRTYNFSQNRITDHRCGLNLYDLEGVISGERLDDVINAVRSFDDNIQAESIIETNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVI7</accession>
    <name>Q6FVI7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0E01573g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVI7"/>
    <dbReference type="FunCoup" id="Q6FVI7">
        <property type="interactions" value="1281"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVI7"/>
    <dbReference type="KEGG" id="cgr:2887514"/>
    <dbReference type="CGD" id="CAL0128876">
        <property type="gene designation" value="CAGL0E01573g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E01573g"/>
    <dbReference type="eggNOG" id="KOG1128">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004905_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FVI7"/>
    <dbReference type="OMA" id="NNRYARA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="633"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="667"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0128876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="904" mass="103165" checksum="59F18538717B5BF1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVP0</accession>
    <name>Q6FVP0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent permease MDL1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MDL1</name>
        <name evidence="11 12" type="ordered locus">CAGL0E00385g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445704.1">
        <property type="nucleotide sequence ID" value="XM_445704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVP0"/>
    <dbReference type="FunCoup" id="Q6FVP0">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVP0"/>
    <dbReference type="GeneID" id="2887523"/>
    <dbReference type="KEGG" id="cgr:2887523"/>
    <dbReference type="CGD" id="CAL0128982">
        <property type="gene designation" value="MDL1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E00385g"/>
    <dbReference type="eggNOG" id="KOG0058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_1"/>
    <dbReference type="InParanoid" id="Q6FVP0"/>
    <dbReference type="OMA" id="MTWLGER"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="49"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="366"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0128982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="66280" checksum="C962449D36B5C2ED" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVQ7</accession>
    <name>Q6FVQ7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">chitin deacetylase</fullName>
            <ecNumber evidence="6">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0D06490g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="6"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445687.1">
        <property type="nucleotide sequence ID" value="XM_445687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVQ7"/>
    <dbReference type="FunCoup" id="Q6FVQ7">
        <property type="interactions" value="43"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVQ7"/>
    <dbReference type="KEGG" id="cgr:2886993"/>
    <dbReference type="CGD" id="CAL0127993">
        <property type="gene designation" value="CAGL0D06490g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D06490g"/>
    <dbReference type="eggNOG" id="ENOG502QRIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030200_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FVQ7"/>
    <dbReference type="OMA" id="QWSIWAM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030476">
        <property type="term" value="P:ascospore wall assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF133">
        <property type="entry name" value="CHITIN DEACETYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0170">Cobalt</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="161"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0127993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="354" mass="40549" checksum="BBF9C06A5BE23259" modified="2004-07-19" version="1">MCAKNMLCSYLLCNFSFGFHLCLRHAAYTSTVVFHVKIKLYSFHAMLINKMRELLVYKLLVLTTISNLTKIVTAYSVLNKMNTELEQQFSKAPFPEWLAQFTQLQDWPGMDPPYIPLDFIDFSKIPEATHYNQLQCETVPRDICSFDCHKCVATDDILSCDSLTQTFDDGPTPATTDLLGNLNHKATFFTLGINIINYPQIYKAIIQRGHDVASHTWSHAHLPSLSNEKIIAQLQWSIWAMNATGNHIPRYFRPPFGGMDNRVRAIARQFGLQAVLWDRDSFDWQLLTPNPKTEEDILKDVCLWKKHDGRGIILEHDTTKQTTDLAIKIERIIGLSQKTVAQCVGGSNYIRQFQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVS6</accession>
    <name>CBP4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Assembly factor CBP4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Cytochrome b mRNA-processing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">CBP4</name>
        <name type="ordered locus">CAGL0D05962g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CBP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445668.1">
        <property type="nucleotide sequence ID" value="XM_445668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVS6"/>
    <dbReference type="SMR" id="Q6FVS6"/>
    <dbReference type="FunCoup" id="Q6FVS6">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVS6"/>
    <dbReference type="EnsemblFungi" id="CAGL0D05962g-T">
        <property type="protein sequence ID" value="CAGL0D05962g-T-p1"/>
        <property type="gene ID" value="CAGL0D05962g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887002"/>
    <dbReference type="KEGG" id="cgr:2887002"/>
    <dbReference type="CGD" id="CAL0127943">
        <property type="gene designation" value="CAGL0D05962g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05962g"/>
    <dbReference type="eggNOG" id="ENOG502S2G8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147520_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVS6"/>
    <dbReference type="OMA" id="KDPIWKT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000330124" description="Assembly factor CBP4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="152" mass="18199" checksum="99B6925CD68364C3" modified="2004-07-19" version="1">MDTPVWRRWLKIYIYGGSIILGGVLLFKYTTPTDEKLIASLSPELRLQYEKERKLRQEEQRELMRIVQETAKSNEPIWKTGPIDSPWEKKKGGEVVKNENFFDKIQKTRAEEAQKDELQRIREELDSLRAQSMKKTSDIVNERKSKDWWKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVT1</accession>
    <name>Q6FVT1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0D05852g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445663.1">
        <property type="nucleotide sequence ID" value="XM_445663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVT1"/>
    <dbReference type="FunCoup" id="Q6FVT1">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVT1"/>
    <dbReference type="KEGG" id="cgr:2887055"/>
    <dbReference type="CGD" id="CAL0127935">
        <property type="gene designation" value="CAGL0D05852g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05852g"/>
    <dbReference type="eggNOG" id="KOG1437">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008441_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVT1"/>
    <dbReference type="OMA" id="FCSSNKR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273619" description="FAS1 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="753"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="31"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="455"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="4">
        <location>
            <begin position="601"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="820"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0127935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG58574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="864" mass="97333" checksum="23B9A3AB5673835F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW08</accession>
    <name>Q6FW08_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein interacting with Hsp90 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0D03916g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW08"/>
    <dbReference type="FunCoup" id="Q6FW08">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW08"/>
    <dbReference type="KEGG" id="cgr:2887147"/>
    <dbReference type="CGD" id="CAL0127953">
        <property type="gene designation" value="CAGL0D03916g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03916g"/>
    <dbReference type="eggNOG" id="KOG4356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072113_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FW08"/>
    <dbReference type="OMA" id="EWCLESC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097255">
        <property type="term" value="C:R2TP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050734">
        <property type="entry name" value="PIH1/Kintoun_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041441">
        <property type="entry name" value="Pih1_CS_Ascomycota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012981">
        <property type="entry name" value="PIH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22997:SF0">
        <property type="entry name" value="PIH1 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08190">
        <property type="entry name" value="PIH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18482">
        <property type="entry name" value="Pih1_fungal_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1 N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Pih1 Ascomycota CS" evidence="3">
        <location>
            <begin position="254"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0127953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="39261" checksum="D5A40004084A8747" modified="2004-07-19" version="1">MDFLLRPIASGDDNQVTVLHPEPLFVIKSKIVNIDNRPKKLLKLEAGSKIFVNLCHDPQAPKPEIPFDPNIVYPLIINNKWEIPIVASSIRTDTDKKGQVCYVIDCCVASDCVKWFVEDYQLKEIVVEWCLEAAELREVIEISRDKISFPKMRKKGDSIPDLEIFSNELDGSDIKEATQNDKGNDPSSLLQIRRDLLSQEEDLSLSNDSDITAHGLPPLFPKANETKGRSLIQEIDDLTLKEKPKNAAKKVQKNIEYNVVMKKIENHKYKLRLDIQIDSITGKSDLNIFYDPTNNDIVLRNLNTDLYDQKDFKIPLPNIFEGKDIMNSSEIFYVNKTGTLTIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW36</accession>
    <name>Q6FW36_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0D03256g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW36"/>
    <dbReference type="FunCoup" id="Q6FW36">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW36"/>
    <dbReference type="ESTHER" id="canga-q6fw36">
        <property type="family name" value="Acidic_Lipase"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887239"/>
    <dbReference type="CGD" id="CAL0128203">
        <property type="gene designation" value="CAGL0D03256g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03256g"/>
    <dbReference type="eggNOG" id="KOG2624">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024238_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FW36"/>
    <dbReference type="OMA" id="TIGANIW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="146"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0128203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="541" mass="63113" checksum="C6F95AB817104A16" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWF7</accession>
    <name>Q6FWF7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ribose-phosphate pyrophosphokinase 1</fullName>
            <ecNumber evidence="5">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Phosphoribosyl pyrophosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0D00550g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="5"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWF7"/>
    <dbReference type="FunCoup" id="Q6FWF7">
        <property type="interactions" value="422"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWF7"/>
    <dbReference type="KEGG" id="cgr:2887109"/>
    <dbReference type="CGD" id="CAL0128461">
        <property type="gene designation" value="CAGL0D00550g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D00550g"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FWF7"/>
    <dbReference type="OMA" id="CKMKKHR"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000017">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000043">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000051">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="18">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0128461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG58348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="429" mass="47414" checksum="6BD8EC8B48EF188C" modified="2004-07-19" version="1">MRKCKVFVGNSHPELGNLVCQRLGIEPAPCTLKKFANGETSVQIGVSVRDEDVYVIQSGSPNINDHIMELLILVSACRGGSAKKITAVIPQFPYSKQCKMKKHRGAITARMLANLLVMAGADHVVSMDLHASQMQGFFTKPVDNLYGGPSLANWIRENVENYEEAVVVSKNPGGTKRVTALADVLKINFAMIHTDRRRAKDLYSQHRDMKQLRQRKQSLLRKNKPIIRQGDDPDEEENIILTNGIQTARIRNGHVIGDDEEDFIPESADEVAMESDAEDASVTDTYGLGGTYDAVDSEDEEEVSEAVKEKLITLVGNVNNRSAIILDDMIDRPGSLISAAEHLVKNCGAKKVYVVATHGLFTGNCLEELEESEVIDKIVVTNTYPISNDRIEKSEKLVVIDVSAIFAECIRRDHYGESISVLFDSLSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWH6</accession>
    <name>Q6FWH6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rho-GTPase-activating protein LRG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0C05599g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWH6"/>
    <dbReference type="FunCoup" id="Q6FWH6">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWH6"/>
    <dbReference type="KEGG" id="cgr:2886878"/>
    <dbReference type="CGD" id="CAL0127560">
        <property type="gene designation" value="CAGL0C05599g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05599g"/>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001321_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FWH6"/>
    <dbReference type="OMA" id="WQMQSSV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000755">
        <property type="term" value="P:cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035024">
        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090334">
        <property type="term" value="P:regulation of cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09393">
        <property type="entry name" value="LIM3_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF7">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="5">
        <location>
            <begin position="425"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="6">
        <location>
            <begin position="740"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0127560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1034" mass="119169" checksum="E15F27D53D214F94" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWJ3</accession>
    <name>Q6FWJ3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein CRT10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0C05225g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWJ3"/>
    <dbReference type="FunCoup" id="Q6FWJ3">
        <property type="interactions" value="98"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWJ3"/>
    <dbReference type="KEGG" id="cgr:2886780"/>
    <dbReference type="CGD" id="CAL0127284">
        <property type="gene designation" value="CAGL0C05225g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05225g"/>
    <dbReference type="eggNOG" id="ENOG502RAS5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013329_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWJ3"/>
    <dbReference type="OMA" id="YSFRQEY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0127284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="877" mass="99982" checksum="0AE6B37955A1B65D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWK3</accession>
    <name>Q6FWK3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0C05005g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWK3"/>
    <dbReference type="FunCoup" id="Q6FWK3">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWK3"/>
    <dbReference type="KEGG" id="cgr:2886923"/>
    <dbReference type="CGD" id="CAL0127414">
        <property type="gene designation" value="CAGL0C05005g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C05005g"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006413_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWK3"/>
    <dbReference type="OMA" id="KYHGFIQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051229">
        <property type="term" value="P:meiotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904750">
        <property type="term" value="P:negative regulation of protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903024">
        <property type="term" value="P:positive regulation of ascospore-type prospore membrane formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0283821-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="342"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="652"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0127414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1076" mass="122682" checksum="B3F1FE037A16B126" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWQ7</accession>
    <name>Q6FWQ7_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0C03674g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWQ7"/>
    <dbReference type="FunCoup" id="Q6FWQ7">
        <property type="interactions" value="12"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886769"/>
    <dbReference type="CGD" id="CAL0127508">
        <property type="gene designation" value="CAGL0C03674g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03674g"/>
    <dbReference type="eggNOG" id="ENOG502RZCP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081665_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWQ7"/>
    <dbReference type="OMA" id="RFYIVNR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0127508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG58243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="288" mass="32306" checksum="2B8263E140FA9E20" modified="2004-07-19" version="1">MAKVSFSKLIASLVSKGRPEVIYSYKTSPLVKYGSKGLSLVFFLYGVSFTDFTVSSSTKILNSASEEQKSDAWFMFKTVGPIGLCVLPFALSAASLYVTSRVVNKVIYIPKHNATPSCQLIRKSMFLGREIKLTRSLKYINRPKKPRVFTGKGIQGIDDNGSFVFYLTDNHPDVRTRLQKFYLLPRSGHVWGSDGRIIDAMFGGESIKELDLLDFENSDKEGNTSGDLSKQRNIELEKDSSILDELIRVNAEKVKFHSDDIKMSSSKIIDIVNSKNTHKNNHKITKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWU9</accession>
    <name>Q6FWU9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sporulation-specific protein SPO7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0C02717g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWU9"/>
    <dbReference type="FunCoup" id="Q6FWU9">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWU9"/>
    <dbReference type="KEGG" id="cgr:2886758"/>
    <dbReference type="CGD" id="CAL0127196">
        <property type="gene designation" value="CAGL0C02717g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02717g"/>
    <dbReference type="eggNOG" id="ENOG502QTI4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065195_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWU9"/>
    <dbReference type="OMA" id="EYKRTIV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071072">
        <property type="term" value="P:negative regulation of phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="33175" checksum="249E2F57FEAF52C8" modified="2004-07-19" version="1">MSVEIPVVKLDEDATVFEETPTKTGRDELPRTPWLEPKQDEAHSRRGSSSNDAGTGGLRKRSGSRTSSGRRSRNSSSISPASMVFRNLLILEDDLRSQSRRLRVLRLQFTAFLSTLAGIAAFSFYLLYFSDEPAQGVYRFILQFSLLFIMITVVLFHLSGQYKRTIIIPRRFFMSTNKGIRPFNLKLVKVHSTIDEKFTDLVRFITRKIAYLNQWFLQKILMLGETNAVVQFWVGVAIRSQPRIGAVDVKLILNPRAFNAEIREGWEIYRDEFWAREGARRRKSNNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWZ9</accession>
    <name>Q6FWZ9_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0C01617g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445245.1">
        <property type="nucleotide sequence ID" value="XM_445245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWZ9"/>
    <dbReference type="KEGG" id="cgr:2886895"/>
    <dbReference type="CGD" id="CAL0127594">
        <property type="gene designation" value="CAGL0C01617g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C01617g"/>
    <dbReference type="HOGENOM" id="CLU_1165693_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWZ9"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273586" evidence="2">
        <location>
            <begin position="20"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="238" mass="26841" checksum="7F04B43EC8D3C482" modified="2004-07-19" version="1">MHFRNILIVLVYLASFISAITNEPKNKAIGIIIDRLEKNTETLKLNGSDSSKITTFYEDIYEINELFSTLYSSFQYPQNELATKAIATLFRLRLTEKDEVTIDYMEDRLFRIKNTLKYALDTKDRMPMHTIAEMQGILTRNRDWLIATSSQIFNKNQDVVKAMADDFPECPPPLAVESSAPKLIALLTDGMIVLALLNSTVDTCMGGFEPLCVFALSAAGTVAGVWLMNVVKYFVLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXC3</accession>
    <name>Q6FXC3_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0B02057g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXC3"/>
    <dbReference type="FunCoup" id="Q6FXC3">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXC3"/>
    <dbReference type="KEGG" id="cgr:2886557"/>
    <dbReference type="CGD" id="CAL0127814">
        <property type="gene designation" value="CAGL0B02057g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B02057g"/>
    <dbReference type="HOGENOM" id="CLU_1042059_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXC3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035260">
        <property type="entry name" value="Fin1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17300">
        <property type="entry name" value="FIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0127814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG57959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="267" mass="30165" checksum="60E65F6988DA7984" modified="2004-07-19" version="1">MDRPLSDIGNVVQGRDTRNVFDRLSISPQKRSSNKRDSVVWKPASRISPKKSNNAPLTTAIHETPKRLQSPSFLKDRSFTQSLDRPQFDPKDIVSATPVNKVKPGIPRSVGNPTTSTFMIPISPTKITFSNEKRTGGDGSSSRILSRMRNIRASPVRSVPSTATTIKKRNLTERLRQEEEGENKNNEKRVRFQVPSQPRPGSSQSSSRTPSRDSNESMTNANKHISRERKAPMPVKTSPDARIDQLENTVRLLEERVKYLEKLLRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXE1</accession>
    <name>Q6FXE1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0B02651g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445086.1">
        <property type="nucleotide sequence ID" value="XM_445086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXE1"/>
    <dbReference type="KEGG" id="cgr:2886697"/>
    <dbReference type="CGD" id="CAL0127684">
        <property type="gene designation" value="CAGL0B02651g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B02651g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040688_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FXE1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="149"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0127684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG57986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="189" mass="21766" checksum="3429D5E69AAD94A0" modified="2004-07-19" version="1">MVRNKLPSVDEDEAFYRLAADAINYVRSPSFQPNAGNTPSLIVHELTLRLTNMNKEVAVPHIKPHLIPMSLDDHVEQIIPSITAQVRREKSGIKTASIEPPNYLYDNGKHTRRRSNQKIYPCNICGISYDKLTDLRKHERASHEPKQENVCMNCGKKFARKDALKRHFDTVLCHVDKRNNQISPRERSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXL3</accession>
    <name>Q6FXL3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0B04873g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXL3"/>
    <dbReference type="FunCoup" id="Q6FXL3">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXL3"/>
    <dbReference type="KEGG" id="cgr:2886599"/>
    <dbReference type="CGD" id="CAL0126972">
        <property type="gene designation" value="CAGL0B04873g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04873g"/>
    <dbReference type="eggNOG" id="KOG0798">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034504_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXL3"/>
    <dbReference type="OMA" id="DSESWPF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035753">
        <property type="term" value="P:maintenance of DNA trinucleotide repeats"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0126972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="42346" checksum="AF619E3FA31C4070" modified="2004-07-19" version="1">MVMKLYSKLQHDTSYKVVQLDDTILAAVKNGEPLQFKSMDETQSEVVLCSSNATWRLKQKNHSNCVMVMKRDTSSNLEDESEFCSLNDTTYEYELTKVPGSLNYHLIPLYDGEELSFKTTFKELLANSQCSNEEAMCEWHDIGGCILESGNICKLSDKFITRALDITLVSIMADSLDMSHLDLDEVLKSVRKDSETVKDNPFTKPVIETILNKFGTQEKDHKWHIDKKRITYWYGLETLKKFAMGISKEQQYPLNQEEFLIKWKSQMPPYFPNSDLDIRELRGHYYLDRHTDEIHYIDKKSLPGDIKQRLVYLFKLQSQWNPDEMAPLMQDLNQKNTKFESFIIKYARIKRLSSKQKVVIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXN8</accession>
    <name>Q6FXN8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein kinase YPK3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0B04301g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXN8"/>
    <dbReference type="FunCoup" id="Q6FXN8">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXN8"/>
    <dbReference type="KEGG" id="cgr:2886569"/>
    <dbReference type="CGD" id="CAL0127920">
        <property type="gene designation" value="CAGL0B04301g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04301g"/>
    <dbReference type="eggNOG" id="KOG0598">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_63_5_1"/>
    <dbReference type="InParanoid" id="Q6FXN8"/>
    <dbReference type="OMA" id="IFRKIDW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000913">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="145"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="467"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0127920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG58057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="60731" checksum="50406CFA1FD087D1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXP9</accession>
    <name>Q6FXP9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0B04037g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG58046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXP9"/>
    <dbReference type="FunCoup" id="Q6FXP9">
        <property type="interactions" value="1041"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXP9"/>
    <dbReference type="KEGG" id="cgr:2886689"/>
    <dbReference type="CGD" id="CAL0127078">
        <property type="gene designation" value="CAGL0B04037g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04037g"/>
    <dbReference type="eggNOG" id="KOG3259">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090028_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FXP9"/>
    <dbReference type="OMA" id="DEVQCLH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of rDNA heterochromatin formation"/>
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        <property type="term" value="P:termination of RNA polymerase II transcription"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
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    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00456">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="7">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="57"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0127078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="173" mass="20108" checksum="F5904D4DFF6DDFA0" modified="2004-07-19" version="1">MSETQEVSTGLPAPWTVRYSKSKKREYFFDPETKKSQWEEPEGTDHEQFISYLKDHPLRVRCLHILIKHKDSRRPASHRQEKITITKEEAIKELKEIQARLEEDQEQKKKHSFEAIAKERSDCSSFKRGGDLGYFGRGEMQPSFEKAAFALKIDEVSDIVESDSGVHLIKRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXR5</accession>
    <name>Q6FXR5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0A04741g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9 10">Cytoplasmic vesicle</location>
            <location evidence="9 10">COPI-coated vesicle membrane</location>
            <topology evidence="9 10">Peripheral membrane protein</topology>
            <orientation evidence="9 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9 10">Golgi apparatus membrane</location>
            <topology evidence="9 10">Peripheral membrane protein</topology>
            <orientation evidence="9 10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXR5"/>
    <dbReference type="FunCoup" id="Q6FXR5">
        <property type="interactions" value="1231"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXR5"/>
    <dbReference type="KEGG" id="cgr:2886396"/>
    <dbReference type="CGD" id="CAL0126745">
        <property type="gene designation" value="CAGL0A04741g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A04741g"/>
    <dbReference type="eggNOG" id="KOG2635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019988_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FXR5"/>
    <dbReference type="OMA" id="VQFRTHP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090167">
        <property type="term" value="P:Golgi distribution to daughter cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000020">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4 9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="284"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="137"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0126745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG57867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="536" mass="59812" checksum="127643CD3D544D81" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXU8</accession>
    <name>Q6FXU8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="15 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ERG4</name>
        <name evidence="19 20" type="ordered locus">CAGL0A00429g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="17">Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="15 18"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444791.1">
        <property type="nucleotide sequence ID" value="XM_444791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXU8"/>
    <dbReference type="SMR" id="Q6FXU8"/>
    <dbReference type="FunCoup" id="Q6FXU8">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXU8"/>
    <dbReference type="GeneID" id="2886295"/>
    <dbReference type="KEGG" id="cgr:2886295"/>
    <dbReference type="CGD" id="CAL0126621">
        <property type="gene designation" value="ERG4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A00429g"/>
    <dbReference type="eggNOG" id="KOG1435">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015631_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FXU8"/>
    <dbReference type="OMA" id="QLPYFCN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0126621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG57682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="464" mass="54897" checksum="489427497190B77A" modified="2004-07-19" version="1">MSGSKEEKKTQSTGFLPQGKYLKPEEIEYEFGGTAGVLGMLIGFPLLMYYMWICAEFYGGRIALPAQNETWAQFIGKLYHIFCDNAIPEKYDLVIFFTFWAFQIFFYYTLPGVWTKGQPLTHLKNKQLPYYCNAMWTLYTSTALVVLLHVTGVFKLYTIIDRFGRIMTCAIASGFAFSIGLYIWTLFVTHDYHRMTGNHLYDFFMGAPLNPRWGILDLKMFFEVRLPWFTLYFITLGACFKQYETYGYVTPQLGVVMLAHWLYANACAKGEELIVPTWDMAYEKFGFMLIFWNIAGVPYTYCHCTLYLYYHNPSEYNWSWQYNLSLYVVLLTAYYFFDTTNGQKNSFRKQMSGDKTVRKTFPFLPYQVLKDPKYMVTSNGSYLLIDGWYRYARKIHYTADWTQSLIWAMSCGFNSFFPWFFPIFFFVVLIHRALRDQAKCEKKYGKDWVEYCKHCPYLFIPYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXV2</accession>
    <name>Q6FXV2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0A00341g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXV2"/>
    <dbReference type="FunCoup" id="Q6FXV2">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886489"/>
    <dbReference type="CGD" id="CAL0126869">
        <property type="gene designation" value="CAGL0A00341g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A00341g"/>
    <dbReference type="eggNOG" id="KOG3292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081702_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FXV2"/>
    <dbReference type="OMA" id="IQFIGHY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102672">
        <property type="term" value="F:fatty acid alpha-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0126869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG57678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21108" checksum="019BAED7A9E21FA3" modified="2004-07-19" version="1">MVTSAAATVTGTNTEVGGLRKELGFYKFYHHNTVNVLIHSVCVPTILFTTICILHRVSLPFQIMGVYLTLGHLLALRFATTYCRLHIPVGICATAILVCTLYALDAGLVGLTLKQESEIFVAAWIMQFIGHGVFEKKKPALLDSLEQSLVLAPYFILFEFLFLLGFFPKLRAELESDVTKLKLQEKRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXV3</accession>
    <name>Q6FXV3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0A00319g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXV3"/>
    <dbReference type="FunCoup" id="Q6FXV3">
        <property type="interactions" value="667"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXV3"/>
    <dbReference type="KEGG" id="cgr:2886383"/>
    <dbReference type="CGD" id="CAL0126655">
        <property type="gene designation" value="CAGL0A00319g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A00319g"/>
    <dbReference type="eggNOG" id="KOG1193">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020349_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FXV3"/>
    <dbReference type="OMA" id="RNCCRLY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="5">
        <location>
            <begin position="17"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="6">
        <location>
            <begin position="167"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0126655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG57677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="509" mass="58880" checksum="5CD5B420F7FA07F0" modified="2004-07-19" version="1">MENKLIIHRPLYFSDKSDCGYCHGKKAKGSDFYSLESWYERIKENADSEVEELPVRSCTVGFQCENMTVAMYDQMCNMGFRRSGLFVYKMDALRSCCRLYTIRTRPDWFKLTKDMRKCINRFRKHVLGEPVANAKTQGYVEDIVDIEGQSDSINFYTRFGPAVYTDEKYELFSIYQERVHQDFDHSKKGFKRFLCDAPFTQGVIMGTEEEWEQLNNWKSMKPGERLLRTGPVHESYYYKGKLIALAVTDFLPSGISSVYFIWHPDYHKWSLGKLSALRELSLVSKTNLKYYYLGYYIDDCKKMNYKANYGGELLDSCTERYFKLSQVKDMIRGGKLFMVGTQGHDISREVALSDAIRDCIYQTDAFDIASDDNVAEKVYGTSSNIYRPQYLKEVISFLKTSGLEYDFPIYNDGVFNQYAKRIAKDGEDPDFTIPSICPGLIPLWELKDLLMSGKLQKELTGRTLVFDTSFGFIRKLEPWEDEDSTTKTAICDVVRLLGLEMASNSIVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY07</accession>
    <name>Q6FY07_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cullin-associated NEDD8-dissociated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0A02024g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY07"/>
    <dbReference type="FunCoup" id="Q6FY07">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886468"/>
    <dbReference type="CGD" id="CAL0126899">
        <property type="gene designation" value="CAGL0A02024g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02024g"/>
    <dbReference type="eggNOG" id="ENOG502S2GH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026649_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FY07"/>
    <dbReference type="OMA" id="ICERRIR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0126899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG57746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="690" mass="79341" checksum="CF996A284D8C2B85" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY16</accession>
    <name>Q6FY16_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HXT1</name>
        <name evidence="12 13" type="ordered locus">CAGL0A01804g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444844.1">
        <property type="nucleotide sequence ID" value="XM_444844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY16"/>
    <dbReference type="FunCoup" id="Q6FY16">
        <property type="interactions" value="1354"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY16"/>
    <dbReference type="GeneID" id="2886473"/>
    <dbReference type="KEGG" id="cgr:2886473"/>
    <dbReference type="CGD" id="CAL0126735">
        <property type="gene designation" value="HXT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01804g"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="Q6FY16"/>
    <dbReference type="OMA" id="EMFQAPR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="61"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0126735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG57737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="563" mass="62315" checksum="38344C237521A13E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-03-01" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q874P0</accession>
    <accession>Q6FX74</accession>
    <accession>Q6FXB5</accession>
    <accession>Q86Z70</accession>
    <accession>Q870I5</accession>
    <name>MTAL1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mating-type-like protein ALPHA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">MTL1ALPHA1</name>
        <name type="synonym">ALPHA1</name>
        <name type="ordered locus">CAGL0B01243g</name>
    </gene>
    <gene>
        <name type="primary">MTL3ALPHA1</name>
        <name type="ordered locus">CAGL0B00242g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Genome Biol." volume="4" first="R10.1" last="R10.9">
            <title>Evidence from comparative genomics for a complete sexual cycle in the 'asexual' pathogenic yeast Candida glabrata.</title>
            <authorList>
                <person name="Wong S."/>
                <person name="Fares M.A."/>
                <person name="Zimmermann W."/>
                <person name="Butler G."/>
                <person name="Wolfe K.H."/>
            </authorList>
            <dbReference type="PubMed" id="12620120"/>
            <dbReference type="DOI" id="10.1186/gb-2003-4-2-r10"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="Eukaryot. Cell" volume="2" first="328" last="340">
            <title>Three mating type-like loci in Candida glabrata.</title>
            <authorList>
                <person name="Srikantha T."/>
                <person name="Lachke S.A."/>
                <person name="Soll D.R."/>
            </authorList>
            <dbReference type="PubMed" id="12684382"/>
            <dbReference type="DOI" id="10.1128/EC.2.2.328-340.2003"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>VARIANT SER-152</scope>
        <source>
            <strain>1480.47</strain>
            <strain>7549</strain>
            <strain>PB921</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="Infect. Immun." volume="71" first="7109" last="7118">
            <title>Phenotypic switching and mating type switching of Candida glabrata at sites of colonization.</title>
            <authorList>
                <person name="Brockert P.J."/>
                <person name="Lachke S.A."/>
                <person name="Srikantha T."/>
                <person name="Pujol C."/>
                <person name="Galask R."/>
                <person name="Soll D.R."/>
            </authorList>
            <dbReference type="PubMed" id="14638801"/>
            <dbReference type="DOI" id="10.1128/IAI.71.12.7109-7118.2003"/>
        </citation>
        <scope>DEVELOPMENTAL STAGE</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional activator that induces the transcription of alpha-specific genes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="developmental stage">
        <text evidence="4">Only present in alpha-cells (classes II and III).</text>
    </comment>
    <comment type="miscellaneous">
        <text>There are three genetic loci for mating type genes in C.glabrata. MTL1 seems to be the expression locus that determines the mating type of the cell, whereas MTL2 (containing MTL2A1) and MTL3 (containing MTL3ALPHA1 and MTL3ALPHA2) appear to represent silenced repositories of mating type information.</text>
    </comment>
    <comment type="miscellaneous">
        <text>Haploid C.glabrata strains can switch mating type, however, neither mating nor diploid forms of C.glabrata have been observed so far.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MATALPHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">It is uncertain whether Met-1 or Met-8 is the initiator.</text>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAP06781" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAP06783" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="AAP06785" version="1"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAG57879" version="2"/>
        </conflict>
    </comment>
    <comment type="sequence caution" evidence="5">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="CAG57924" version="2"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AY181247">
        <property type="protein sequence ID" value="AAO25591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY191463">
        <property type="protein sequence ID" value="AAP06781.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY191464">
        <property type="protein sequence ID" value="AAP06783.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY207368">
        <property type="protein sequence ID" value="AAP06785.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57879.2"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380948">
        <property type="protein sequence ID" value="CAG57924.2"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q874P0"/>
    <dbReference type="STRING" id="284593.Q874P0"/>
    <dbReference type="KEGG" id="cgr:2886617"/>
    <dbReference type="KEGG" id="cgr:2886684"/>
    <dbReference type="eggNOG" id="ENOG502S4ZK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118234_1_0_1"/>
    <dbReference type="InParanoid" id="Q874P0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045895">
        <property type="term" value="P:positive regulation of mating-type specific transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016325">
        <property type="entry name" value="ALPHA1_Saccharomycetales"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006856">
        <property type="entry name" value="MATalpha_HMGbox"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04769">
        <property type="entry name" value="MATalpha_HMGbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001863">
        <property type="entry name" value="Transcrpt_activ_MAT_Alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51325">
        <property type="entry name" value="ALPHA_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0010">Activator</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000206008" description="Mating-type-like protein ALPHA1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Alpha box" evidence="2">
        <location>
            <begin position="118"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="sequence variant" description="In strain: 7549." evidence="3">
        <original>A</original>
        <variation>S</variation>
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="12684382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="14638801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="191" mass="21894" checksum="DD2C4436484BC495" modified="2003-06-01" version="1">MLTETLTMKYTATKFRVRTNKRLRSQKYPEKHSDFLGCSSTKSSFGLNMLLTKPNKFQIPPPHPVLLKRIREERMKLTSSFESGINIIDIETSWEIDKFISHHFNTSIGNVLKSKSSSKKRPMNAFMAFRTYYAQLGTGLKQNTLSVILSEAWNAPETDQNIWDIFAQQFNFASPRCGFVNYIMAHASSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B4UMY3</accession>
    <name>B4UMY3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome c oxidase subunit 8, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Cytochrome c oxidase polypeptide VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0C02623g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase VIIc family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAR58007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UMY3"/>
    <dbReference type="FunCoup" id="B4UMY3">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UMY3"/>
    <dbReference type="KEGG" id="cgr:9487972"/>
    <dbReference type="CGD" id="CAL0127640">
        <property type="gene designation" value="CAGL0C02623g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C02623g"/>
    <dbReference type="eggNOG" id="KOG4527">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169812_0_0_1"/>
    <dbReference type="InParanoid" id="B4UMY3"/>
    <dbReference type="OMA" id="IHNRKIP"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00929">
        <property type="entry name" value="Cyt_c_Oxidase_VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.49.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.49.10">
        <property type="entry name" value="Cytochrome c oxidase subunit VIIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004202">
        <property type="entry name" value="COX7C/Cox8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036636">
        <property type="entry name" value="COX7C/Cox8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7C, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13313">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT VIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02935">
        <property type="entry name" value="COX7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81427">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIIc (aka VIIIa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0127640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAR58007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="73" mass="8299" checksum="74D712DB225A1BA4" modified="2008-09-23" version="1">MFSQQVMRLSTRRAFSASSIARVHFKEGVYSNLPFKIHNRKIPFALVHFGFFGVGFAVPFIACYVQMKKAGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIJ4</accession>
    <name>Q6FIJ4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein GLC8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M13937g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIJ4"/>
    <dbReference type="FunCoup" id="Q6FIJ4">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2891612"/>
    <dbReference type="CGD" id="CAL0136695">
        <property type="gene designation" value="CAGL0M13937g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13937g"/>
    <dbReference type="eggNOG" id="ENOG502S2VH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070379_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FIJ4"/>
    <dbReference type="OMA" id="QQFQDIH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27955" checksum="1213A21F924E0578" modified="2004-07-19" version="1">MGGILKNAVRKEEGDGAQEAQSLSDFRKQVYKNTQLNAQLTSRKRDTPIDTLHLNENGEEEDVTLSPSRRRGPPKDTLLMKREHDALEKQKEEMKNMTEEERLQWNQKNLDENEITKQQFQDIHVDEPKTPYQGAVDPEGEYYKVDDDEEDDDDDGKKKQGHLDDLDDFSLGEPEYKVSATADNGIIDAEDDESDAEPEELTPEEKHRRFEEMRKKHYNVKEVFRNKQALEDLDDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIJ7</accession>
    <name>Q6FIJ7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PSE1</name>
        <name evidence="9 10" type="ordered locus">CAGL0M13871g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="GeneID" id="2891609"/>
    <dbReference type="KEGG" id="cgr:2891609"/>
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        <property type="gene designation" value="PSE1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13871g"/>
    <dbReference type="eggNOG" id="KOG2171">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003794_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FIJ7"/>
    <dbReference type="OMA" id="PKRFVQE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007088">
        <property type="term" value="P:regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060188">
        <property type="term" value="P:regulation of protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040928">
        <property type="entry name" value="Importin_rep_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041389">
        <property type="entry name" value="Importin_rep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18816">
        <property type="entry name" value="Importin_rep_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18829">
        <property type="entry name" value="Importin_rep_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="350"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0136855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG62927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1091" mass="120985" checksum="419017F79B3E34EC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIQ5</accession>
    <name>Q6FIQ5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M12573g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIQ5"/>
    <dbReference type="FunCoup" id="Q6FIQ5">
        <property type="interactions" value="483"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIQ5"/>
    <dbReference type="KEGG" id="cgr:2891440"/>
    <dbReference type="CGD" id="CAL0136899">
        <property type="gene designation" value="CAGL0M12573g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M12573g"/>
    <dbReference type="eggNOG" id="KOG0113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045151_4_1_1"/>
    <dbReference type="InParanoid" id="Q6FIQ5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21615">
        <property type="entry name" value="RRM_SNP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952:SF5">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="115"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="299" mass="34623" checksum="4062EFD3B16E1C44" modified="2004-07-19" version="1">MKIKAASAMSLGSQRTTSRKQDMSLFKARPSLPFKRQNQRVARDARIEPLSQVSPEILTANYLMQFPRETATLRHLERMDAVAKRVRDNQREVEQQLLQWDPLSDNHMRDTDPYKTVFVGRLPYDTDEVQLQKVFAKYGEIVRVRVVRDKQNKSRGYAFVLFKETDSARVCTRDIGVHRGIQINGRRCIVDIERGRTIKFFKPRRLGGGLGGRGYQSLHSEHTQPHVNPPAQHVPQRYGERRPEYQPRGRYQGARQGARQGAYQPQQTLPASNPQAPAEPEPRTSYRSRTARQREEIDY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIV0</accession>
    <name>LCL2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">LCL2</name>
        <name type="ordered locus">CAGL0M11572g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449844.1">
        <property type="nucleotide sequence ID" value="XM_449844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIV0"/>
    <dbReference type="FunCoup" id="Q6FIV0">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIV0"/>
    <dbReference type="EnsemblFungi" id="CAGL0M11572g-T">
        <property type="protein sequence ID" value="CAGL0M11572g-T-p1"/>
        <property type="gene ID" value="CAGL0M11572g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891238"/>
    <dbReference type="KEGG" id="cgr:2891238"/>
    <dbReference type="CGD" id="CAL0137141">
        <property type="gene designation" value="CAGL0M11572g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M11572g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11572g"/>
    <dbReference type="eggNOG" id="ENOG502S416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142363_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FIV0"/>
    <dbReference type="OMA" id="KPATHDE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23996">
        <property type="entry name" value="LCL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000408601" description="Long chronological lifespan protein 2">
        <location>
            <begin position="15"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="119" mass="13477" checksum="98A24AC112C3B154" modified="2004-07-19" version="1" precursor="true">MNLLMVLFVAQAHAFFFGQQQQQQQQQASYEDRVLDSGCAKYLCSDTLECVDSWKDCPCPFPKSQLKCMLPKGSNRPYVCISKPATHDEKLNLIYDDPVQGPKAAIKGMRDCGWVQQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIV5</accession>
    <name>Q6FIV5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M11462g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIV5"/>
    <dbReference type="FunCoup" id="Q6FIV5">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIV5"/>
    <dbReference type="ESTHER" id="canga-q6fiv5">
        <property type="family name" value="CGI-58_ABHD5_ABHD4"/>
    </dbReference>
    <dbReference type="MEROPS" id="S33.A42"/>
    <dbReference type="KEGG" id="cgr:2891408"/>
    <dbReference type="CGD" id="CAL0136795">
        <property type="gene designation" value="CAGL0M11462g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11462g"/>
    <dbReference type="eggNOG" id="KOG4409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017361_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FIV5"/>
    <dbReference type="OMA" id="ARDPIMD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF23">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE ICT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="48"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0136795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="386" mass="44553" checksum="1F58363365217E51" modified="2004-07-19" version="1">MWCKGDDLETLQYKVMEEVPVEGQRAVLRCGVNQWYFRGGDRVVTPTLLVHGYGASSMAYHRCFAPLSRHIRDLYAIDLPANGLSEAPPLVAEGEAPKAKFKIEENKFTVVQGARRAAEPVTDAQVDQELMLRTHREKRRYLQQYEDYYVESIEQWRKENNLDKFNLVGHSFGGYLSYKYALKYPESVNKLCLLSPLGMERNIHSINNTFEENVVYELQESDPSSYLYTRKRKAPKFLFENQFSVLRWMGPIGDKLCLSFINSSYAKVPSQAYKDYLFESFLGKKHFAKQNVHALKHLFTRSLLARDPIMDTIDKLKVPDVSVFYGDHDWMNSYAGYLMVERLKKFRVASTSGGSASYLEVPDAGHNLFLDNPDYFSKKLVQFLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIW1</accession>
    <name>Q6FIW1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M11330g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449833.1">
        <property type="nucleotide sequence ID" value="XM_449833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIW1"/>
    <dbReference type="FunCoup" id="Q6FIW1">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIW1"/>
    <dbReference type="KEGG" id="cgr:2891402"/>
    <dbReference type="CGD" id="CAL0137199">
        <property type="gene designation" value="CAGL0M11330g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M11330g"/>
    <dbReference type="eggNOG" id="KOG1944">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049109_8_0_1"/>
    <dbReference type="InParanoid" id="Q6FIW1"/>
    <dbReference type="OMA" id="FYRWICF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF50">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YOR292C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0137199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="35088" checksum="F465A6334F2F2225" modified="2004-07-19" version="1">MTIALPGVDGSTAYNYAVRQRNVFRTVFTANVFHISLTHWFLMFCWLNLMWRYYFNHYKDLYKYNRLIASQLSNCMLFGLSDILAQCITCYFSREMDPVPRIIDETVQNLIPYNVMPLPGGIFEANEELLDSDNDDNLSVFNDYGEYDNSNDEIEYNHTEKVATFHFRRWLGFMGWGGFISFFQVPWYIILNTIYTEDPTVVQVLERVLTDQLLYSPVSLYFFFMYSNYVIEQGDRYTFSMKIRRLYVTTLGCNYMIWPMMQFINFLVIPKHYQVPFSSSVGVVWNCFLSMRNAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ41</accession>
    <name>Q6FJ41_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RTG3</name>
        <name evidence="8 9" type="ordered locus">CAGL0M09405g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449753.1">
        <property type="nucleotide sequence ID" value="XM_449753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ41"/>
    <dbReference type="FunCoup" id="Q6FJ41">
        <property type="interactions" value="948"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ41"/>
    <dbReference type="GeneID" id="2891317"/>
    <dbReference type="KEGG" id="cgr:2891317"/>
    <dbReference type="CGD" id="CAL0136259">
        <property type="gene designation" value="RTG3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M09405g"/>
    <dbReference type="eggNOG" id="KOG1318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043302_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ41"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071400">
        <property type="term" value="P:cellular response to oleic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000105">
        <property type="entry name" value="Rtg3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF2">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="261"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="451" mass="50139" checksum="8F0A7BB74D965611" modified="2004-07-19" version="1">MEINNEDHELLAEIMGHGGDGSELFGNDADVFLRNGSGSGETQAGNADGLALYPQATPAHRHEQMAMMNHGNSEMHSFLDDMFTNSSLGHGQPVTESNLTKNMMGNHYEQNLESDIASSLYNSRHPSVSMEHGTAGHPEMLFHQNDNSISSFSESFYGSSLDSSISEVSSINSFMSGNSFPAPLPHQIDENSILVNNNMSPSGFRDSIRPGSFLSTSLRAPSSMSRQMRNPSYNDSGIPMTVGSVPKNATSHMTPDEKLKRKREFHNAVERRRRELIKQKIKELSKLVPPSLLNYDADGNQIKSNRGTILDKSVEYLEYLLYVIDIQKRKREALQEKIAQLSSLSSRTTDDLGMGPRKMTNLPQRISSQATLKANTFNEEKIIDTRGIPDTRGISASQAHTDNPLEDFNHNHVDFNATHTDFNNNINDDLQQFLSGDLMEAEDNAKLMFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJ86</accession>
    <name>Q6FJ86_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M08338g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJ86"/>
    <dbReference type="FunCoup" id="Q6FJ86">
        <property type="interactions" value="455"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJ86"/>
    <dbReference type="KEGG" id="cgr:2891267"/>
    <dbReference type="CGD" id="CAL0136611">
        <property type="gene designation" value="CAGL0M08338g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08338g"/>
    <dbReference type="eggNOG" id="KOG0901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FJ86"/>
    <dbReference type="OMA" id="IVCVVQK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="138" mass="14903" checksum="473FEDC76A9C1B0C" modified="2004-07-19" version="1">MIYLKSIIKVIDNSGAQLAECIKVIGKGSPKSPGRVGDRIVCVIQKARPLTQNITGTATTNRVKKGDICHAIVVRTKQTNEYRRDGSMISFGDNACVLINKNTGEPLGTRIMANDGVVDRTLKDKGFNKICSLASKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJA0</accession>
    <name>Q6FJA0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0M08008g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FJA0">
        <property type="interactions" value="93"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJA0"/>
    <dbReference type="KEGG" id="cgr:2891746"/>
    <dbReference type="CGD" id="CAL0136409">
        <property type="gene designation" value="CAGL0M08008g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M08008g"/>
    <dbReference type="eggNOG" id="KOG1064">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000310_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJA0"/>
    <dbReference type="OMA" id="NSHLTLW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043254">
        <property type="term" value="P:regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="572"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1317"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1349"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1321"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0136409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1388" mass="159274" checksum="030A68903813439D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-01-04" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJA3</accession>
    <accession>Q8J134</accession>
    <name>PDC1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pyruvate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PDC1</name>
        <name type="synonym">PDC</name>
        <name type="ordered locus">CAGL0M07920g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="J. Biochem." volume="136" first="447" last="455">
            <title>Purification, characterization, cloning and expression of pyruvate decarboxylase from Torulopsis glabrata IFO005.</title>
            <authorList>
                <person name="Wang Q."/>
                <person name="He P."/>
                <person name="Lu D."/>
                <person name="Shen A."/>
                <person name="Jiang N."/>
            </authorList>
            <dbReference type="PubMed" id="15625313"/>
            <dbReference type="DOI" id="10.1093/jb/mvh141"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <source>
            <strain>JCM 3699 / NBRC 0005</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>pyruvate + H(+) = acetaldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:45484"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="2">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="AF545432">
        <property type="protein sequence ID" value="AAN77243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449691.1">
        <property type="nucleotide sequence ID" value="XM_449691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJA3"/>
    <dbReference type="SMR" id="Q6FJA3"/>
    <dbReference type="FunCoup" id="Q6FJA3">
        <property type="interactions" value="1067"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJA3"/>
    <dbReference type="EnsemblFungi" id="CAGL0M07920g-T">
        <property type="protein sequence ID" value="CAGL0M07920g-T-p1"/>
        <property type="gene ID" value="CAGL0M07920g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891742"/>
    <dbReference type="KEGG" id="cgr:2891742"/>
    <dbReference type="CGD" id="CAL0137069">
        <property type="gene designation" value="PDC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M07920g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07920g"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FJA3"/>
    <dbReference type="OMA" id="IHGPEQR"/>
    <dbReference type="BRENDA" id="4.1.1.1">
        <property type="organism ID" value="1113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000018">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="chain" id="PRO_0000090762" description="Pyruvate decarboxylase">
        <location>
            <begin position="1"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="413"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="445"/>
            <end position="446"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="471"/>
            <end position="476"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAN77243." evidence="4" ref="1">
        <original>I</original>
        <variation>T</variation>
        <location>
            <position position="559"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 1; AAN77243." evidence="4" ref="1">
        <location>
            <position position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P06169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="15625313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="564" mass="61906" checksum="A0F08DE36A96D2AA" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJJ6</accession>
    <name>Q6FJJ6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pseudouridine synthase I TruA alpha/beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">CAGL0M05797g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a uridine in tRNA = a pseudouridine in tRNA</text>
            <dbReference type="Rhea" id="RHEA:54572"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13934"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJJ6"/>
    <dbReference type="STRING" id="284593.Q6FJJ6"/>
    <dbReference type="KEGG" id="cgr:2891646"/>
    <dbReference type="eggNOG" id="KOG2553">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021971_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FJJ6"/>
    <dbReference type="OMA" id="CDARTYT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="7">
        <location>
            <begin position="146"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00036943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="317" mass="36069" checksum="81714185D5E2D0BC" modified="2004-07-19" version="1">MALVLGYLGTGYQGIQYNPPAHTIDNELFKALVATNCISQSNSDDFSKSSFSRATRTDKGVHALTNLVALKMQRYEVPQQVKAELNEILPDDIRIWDVVPVKKKFNARVMAGTRHYRYVIPTFLLQCGPHSDLSTSQLARFKNIWNMFLGTHNYYNFTPRRKDTNADSPQNMRHMYSIQVSDPFTIAGSTQWLSIAIHGQSFLLHQIRKMVHYALSEYHRSSSDTKSMELLETVDPDLTSATALDTPTEQYIPLAPAAGLYLHHPTFEGYNNQPAARRLQVLDLSGYPACATFEDRIHTEIARSEHVFHEYMAVIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJL5</accession>
    <name>Q6FJL5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bud emergence protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M05357g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJL5"/>
    <dbReference type="FunCoup" id="Q6FJL5">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJL5"/>
    <dbReference type="KEGG" id="cgr:2891626"/>
    <dbReference type="CGD" id="CAL0136427">
        <property type="gene designation" value="CAGL0M05357g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05357g"/>
    <dbReference type="eggNOG" id="KOG4773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014957_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJL5"/>
    <dbReference type="OMA" id="FICAHHN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120157">
        <property type="term" value="C:PAR polarity complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000753">
        <property type="term" value="P:cell morphogenesis involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045185">
        <property type="term" value="P:maintenance of protein location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061191">
        <property type="term" value="P:positive regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11879">
        <property type="entry name" value="SH3_Bem1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000093">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035549">
        <property type="entry name" value="Bem1/Scd2_SH3_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="62"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="287"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="484"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="62965" checksum="986C0A919953A771" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJS0</accession>
    <name>PFS2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">PFS2</name>
        <name type="ordered locus">CAGL0M04081g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449524.1">
        <property type="nucleotide sequence ID" value="XM_449524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJS0"/>
    <dbReference type="SMR" id="Q6FJS0"/>
    <dbReference type="FunCoup" id="Q6FJS0">
        <property type="interactions" value="256"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJS0"/>
    <dbReference type="EnsemblFungi" id="CAGL0M04081g-T">
        <property type="protein sequence ID" value="CAGL0M04081g-T-p1"/>
        <property type="gene ID" value="CAGL0M04081g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891533"/>
    <dbReference type="KEGG" id="cgr:2891533"/>
    <dbReference type="CGD" id="CAL0136357">
        <property type="gene designation" value="CAGL0M04081g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M04081g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04081g"/>
    <dbReference type="eggNOG" id="KOG0284">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_77_0_1"/>
    <dbReference type="InParanoid" id="Q6FJS0"/>
    <dbReference type="OMA" id="HHWDVKS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0853">WD repeat</keyword>
    <feature type="chain" id="PRO_0000238499" description="Polyadenylation factor subunit 2">
        <location>
            <begin position="1"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 1">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 2">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 3">
        <location>
            <begin position="164"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 4">
        <location>
            <begin position="206"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 5">
        <location>
            <begin position="248"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 6">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD 7">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="455" mass="51570" checksum="58AE916549E3C8E2" modified="2004-07-19" version="1">MDQSAAVEGVPQKKYLTLRRSVDVSSSYNRLYYLKKHGLSLPPIEPETSFTANIMPPDAYKRNDRIVNLPTKFTHLSSNKVKHVIPAIQWSPEGRRLIVATFSGEFSLWNGSSFTFETIMQAHDTSVTTMKYSHAGDWMISGDADGTIKIWQPNFNMVKELDRIHTEGIRDVAFSNNDSKFVTCSDDNILKIWNFSNGQQERVLSGHHWDVRSCDWHPELGLIVSGSKDNLVKLWDPRSGQCVSTLLKFKHTVLKTRFQPTKGNLLAAISKDKSCRVFDLRASMNELMCVRDEVDFMELEWSTINESMFTVGCYDGSLKHFDLGQDTEKPIHIIPFAHEKCISAIAYNPVGHILATAAKDRTIRFWTRARPVDPNAFDDPTYNNKKMTGWFFGINNDINAVREKSEYGAAPPPASTAFPQQTQYNNNISRVPEIKEPTPTTDKEQRTSILPGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK43</accession>
    <name>Q6FK43_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI-anchor transamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0M01298g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK43"/>
    <dbReference type="FunCoup" id="Q6FK43">
        <property type="interactions" value="702"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK43"/>
    <dbReference type="MEROPS" id="C13.005"/>
    <dbReference type="KEGG" id="cgr:2891170"/>
    <dbReference type="CGD" id="CAL0136869">
        <property type="gene designation" value="CAGL0M01298g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01298g"/>
    <dbReference type="eggNOG" id="KOG1349">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044656_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FK43"/>
    <dbReference type="OMA" id="VMESQFP"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000003">
        <property type="entry name" value="GPI-anchor transamidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5028332333" description="GPI-anchor transamidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0136869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG62377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44441" checksum="DCF29F59B5D13A50" modified="2004-07-19" version="1">MRIVLPCLLWLVTLACGVVNAEHTNNWAVLVSTSRFWFNYRHMANVLSMYRTVRRLGIPDSQIILMLSDDVACNSRNLFPGSVFNNKDHAIDLYGESVEVDYRGYEVTVENFIRLLTDRWTEDQPKSKRLQTDENSNIFIYLTGHGGDDFLKFQDAEEIASEDIADAFAQMYEKKRYNEIFFMIDTCQANTMYSKFYSPNVLAVGSSELDESSYSHHSDVEIGVAVIDRFTYYSLEFLEQIDKTSNLTLKDLFDSYTFEKVHSHVGVRSDLFKRNVSDVLITDFFANVQNVIPDDNSGKTSGNNEDIIDLAIQKSQLASKKDKSSQTPKPKEPASSIYFRTASSLNKNITDAKNNSNEGLMTVLLIILVMLGLYTTFKRTSKKETAKFSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKB6</accession>
    <name>TCTP_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Translationally-controlled tumor protein homolog</fullName>
            <shortName>TCTP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAGL0L12870g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein synthesis. Involved in microtubule stabilization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKB6"/>
    <dbReference type="SMR" id="Q6FKB6"/>
    <dbReference type="FunCoup" id="Q6FKB6">
        <property type="interactions" value="932"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKB6"/>
    <dbReference type="EnsemblFungi" id="CAGL0L12870g-T">
        <property type="protein sequence ID" value="CAGL0L12870g-T-p1"/>
        <property type="gene ID" value="CAGL0L12870g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890578"/>
    <dbReference type="CGD" id="CAL0136162">
        <property type="gene designation" value="CAGL0L12870g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L12870g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12870g"/>
    <dbReference type="eggNOG" id="KOG1727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095877_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKB6"/>
    <dbReference type="OMA" id="CAMITEG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.10:FF:000002">
        <property type="entry name" value="Translationally-controlled tumor protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01003">
        <property type="entry name" value="TCTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000252320" description="Translationally-controlled tumor protein homolog">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TCTP" evidence="2">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <sequence length="167" mass="18681" checksum="B7B12E69487FE580" modified="2004-07-19" version="1">MIIYKDIFSGDELLSDAYDINEVDGVIYEADCAMVKVGGDNIDIGANPSTEDGEDDVEDGTEVVNNVVHSFRLQPTGFDKKSFLTYIKGYMKAVKAKLQEKNPDAIPTFEKGAQVYVKKVIGSFKDWEFFTGESMDPDAMVVMLNYREDGTTPFVAIWKHGIDEEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKG2</accession>
    <name>Q6FKG2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein BCK2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L11836g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKG2"/>
    <dbReference type="FunCoup" id="Q6FKG2">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKG2"/>
    <dbReference type="KEGG" id="cgr:2890946"/>
    <dbReference type="CGD" id="CAL0135216">
        <property type="gene designation" value="CAGL0L11836g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11836g"/>
    <dbReference type="eggNOG" id="ENOG502RH5A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016939_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKG2"/>
    <dbReference type="OMA" id="GHRKKQE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="847" mass="92882" checksum="DE6E44CF96A9C6DB" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKH1</accession>
    <name>RTC5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Restriction of telomere capping protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">RTC5</name>
        <name type="ordered locus">CAGL0L11616g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RTC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449273.1">
        <property type="nucleotide sequence ID" value="XM_449273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKH1"/>
    <dbReference type="SMR" id="Q6FKH1"/>
    <dbReference type="FunCoup" id="Q6FKH1">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKH1"/>
    <dbReference type="EnsemblFungi" id="CAGL0L11616g-T">
        <property type="protein sequence ID" value="CAGL0L11616g-T-p1"/>
        <property type="gene ID" value="CAGL0L11616g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890973"/>
    <dbReference type="KEGG" id="cgr:2890973"/>
    <dbReference type="CGD" id="CAL0135142">
        <property type="gene designation" value="CAGL0L11616g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11616g"/>
    <dbReference type="eggNOG" id="ENOG502QV3R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011918_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKH1"/>
    <dbReference type="OMA" id="TIMELTP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032984">
        <property type="term" value="P:protein-containing complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000408819" description="Restriction of telomere capping protein 5">
        <location>
            <begin position="1"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="TLDc" evidence="2">
        <location>
            <begin position="280"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="555" mass="62104" checksum="76D887EBCF844D79" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-18" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKH7</accession>
    <name>FKBP3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>FK506-binding protein 3</fullName>
            <ecNumber>5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName>PPIase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">FPR3</name>
        <name type="ordered locus">CAGL0L11484g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Inhibited by both FK506 and rapamycin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449267.1">
        <property type="nucleotide sequence ID" value="XM_449267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKH7"/>
    <dbReference type="SMR" id="Q6FKH7"/>
    <dbReference type="FunCoup" id="Q6FKH7">
        <property type="interactions" value="614"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKH7"/>
    <dbReference type="EnsemblFungi" id="CAGL0L11484g-T">
        <property type="protein sequence ID" value="CAGL0L11484g-T-p1"/>
        <property type="gene ID" value="CAGL0L11484g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890967"/>
    <dbReference type="KEGG" id="cgr:2890967"/>
    <dbReference type="CGD" id="CAL0135700">
        <property type="gene designation" value="FPR3"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L11484g"/>
    <dbReference type="eggNOG" id="KOG0552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022297_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FKH7"/>
    <dbReference type="OMA" id="CPPHMAY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000233077" description="FK506-binding protein 3">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="2">
        <location>
            <begin position="351"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="437" mass="49671" checksum="DEAA67DE23626C91" modified="2004-07-19" version="1">MSDMLPLATYSLNVLPYIPTPAIDIEMPVTVRITMAALDPEALDDQKQPSTLRIVKRNPNFDDEEYDDLLNGDYDEDEMASDDEEEEEEEEEEEKPAKKSKKSKGKKKDESEDEEEEEESDSDLDEEDDDDEFEEYVLATLSPKTQYQQTLDLTIAPEEEIQFIVTGSYAISLVGNYIKHPFDTPMGDMDDSEDEDGSDYDDELSDSYYNDQYSDDDAEDSDEHDLTPDEDELAPAGSVEEIEASEEEESEEEEKKSKHKKHDHHHHHDHDHDHDHEHKSKNKKRKQEEEEPKKEHKDKKVKFKKDLEEGPTKKEKAESKKADKTPKRRTLEGGVVIEDRTVGDGPAAKKGDRVGMRYIGKLKNGKVFDKNTSGKPFVFKLGRGEVIKGWDVGVAGMSVGSERRIIIPAPYAYGKQALPGIPANSELTFDVKLVSIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-02-20" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKM3</accession>
    <name>ALG8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.265</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Asparagine-linked glycosylation protein 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ALG8</name>
        <name type="ordered locus">CAGL0L10450g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.265" evidence="1"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449221.1">
        <property type="nucleotide sequence ID" value="XM_449221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKM3"/>
    <dbReference type="SMR" id="Q6FKM3"/>
    <dbReference type="FunCoup" id="Q6FKM3">
        <property type="interactions" value="835"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKM3"/>
    <dbReference type="CAZy" id="GT57">
        <property type="family name" value="Glycosyltransferase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0L10450g-T">
        <property type="protein sequence ID" value="CAGL0L10450g-T-p1"/>
        <property type="gene ID" value="CAGL0L10450g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891072"/>
    <dbReference type="KEGG" id="cgr:2891072"/>
    <dbReference type="CGD" id="CAL0135006">
        <property type="gene designation" value="ALG8"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10450g"/>
    <dbReference type="eggNOG" id="KOG2576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022045_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FKM3"/>
    <dbReference type="OMA" id="YHSTDFD"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000278329" description="Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase">
        <location>
            <begin position="1"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="211"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="299"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
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        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="414"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="439"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="462"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P40351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="550" mass="64425" checksum="19A8CF44E995D93D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKN0</accession>
    <name>Q6FKN0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase spindle elongation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L10252g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKN0"/>
    <dbReference type="FunCoup" id="Q6FKN0">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKN0"/>
    <dbReference type="KEGG" id="cgr:2891064"/>
    <dbReference type="CGD" id="CAL0135352">
        <property type="gene designation" value="CAGL0L10252g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10252g"/>
    <dbReference type="eggNOG" id="KOG4302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_333226_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKN0"/>
    <dbReference type="OMA" id="KRITRHF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051256">
        <property type="term" value="P:mitotic spindle midzone assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000920">
        <property type="term" value="P:septum digestion after cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="433"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0135352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="845" mass="97334" checksum="4710DBBE3E729D22" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKR5</accession>
    <name>Q6FKR5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L09273g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKR5"/>
    <dbReference type="FunCoup" id="Q6FKR5">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKR5"/>
    <dbReference type="KEGG" id="cgr:2891124"/>
    <dbReference type="CGD" id="CAL0135030">
        <property type="gene designation" value="CAGL0L09273g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09273g"/>
    <dbReference type="eggNOG" id="KOG1260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019214_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FKR5"/>
    <dbReference type="OMA" id="TVPHADF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF13">
        <property type="entry name" value="MITOCHONDRIAL 2-METHYLISOCITRATE LYASE ICL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="455"/>
            <end position="459"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="571" mass="65107" checksum="A117CEE232B9ABAD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKS9</accession>
    <name>Q6FKS9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L08954g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKS9"/>
    <dbReference type="FunCoup" id="Q6FKS9">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKS9"/>
    <dbReference type="KEGG" id="cgr:2891096"/>
    <dbReference type="CGD" id="CAL0135136">
        <property type="gene designation" value="CAGL0L08954g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08954g"/>
    <dbReference type="eggNOG" id="KOG2016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019618_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FKS9"/>
    <dbReference type="OMA" id="KLITHQY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="52333" checksum="692396262956167D" modified="2004-07-19" version="1">MSQIFDRYDRQLRLWGHDGQHLLENSHITIVIDNDANKTVDLLEETLKNVILVGVKNITLNNLCDCKLDNVIRNVLPLNDGVHIDQTTDPLSLMNASPQTDLFLLLNLDNKAEALFTNNPFKIKSIATHVNGMLGHIRMYYPSPHFISNTHSDRNIPDLRLKDPWPEYKSFLNSFDDDLKNDVAAATVPYPVILYKVIDGVTNPSTKAIKQRLEEVYLTRYKKDAFYDLNYEQAKKYAYLINANDNIYDTKFVPVFEFVKELITSPRECSKYLSKYDKKLLNLILTTEQFISKYGRIPFRGILPDLESSSENYARLKKIFIEKFSSDCKDFSTLYDMQFCDEKLNSNEIQEFLKNLDDIAVVEPNMPQTITTTNTKYSEESNSYLKLVNGETNIDNIDNSLRTSLQLESYSVTTMLGSIASQEIFKLITHQFVPIKNIFIYNATNQTTELIEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKV3</accession>
    <name>Q6FKV3_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L08382g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKV3"/>
    <dbReference type="FunCoup" id="Q6FKV3">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKV3"/>
    <dbReference type="KEGG" id="cgr:2890616"/>
    <dbReference type="CGD" id="CAL0135602">
        <property type="gene designation" value="CAGL0L08382g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08382g"/>
    <dbReference type="eggNOG" id="ENOG502S0YM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071343_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FKV3"/>
    <dbReference type="OMA" id="FPMQGGL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071464">
        <property type="term" value="P:cellular response to hydrostatic pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="140" mass="15887" checksum="EE29DA65AD4E3087" modified="2004-07-19" version="1">MKSFITSTDVPIGYKTPSFPSLYWPINDRRYDTAFLYFIEDIWKFTLYWTFIFNGAFYGGAGLYASLTHWKRGGGLWIFGIYMLYAGVQGMIIGTVMGFLIGAIYRSGLFSMSTWVPMCCAVVQILLDVTMSYSMVGSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKW2</accession>
    <name>Q6FKW2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FEN1</name>
        <name evidence="13 14" type="ordered locus">CAGL0L08184g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKW2"/>
    <dbReference type="SMR" id="Q6FKW2"/>
    <dbReference type="FunCoup" id="Q6FKW2">
        <property type="interactions" value="674"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKW2"/>
    <dbReference type="KEGG" id="cgr:2890559"/>
    <dbReference type="CGD" id="CAL0135906">
        <property type="gene designation" value="FEN1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08184g"/>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048483_6_1_1"/>
    <dbReference type="InParanoid" id="Q6FKW2"/>
    <dbReference type="OMA" id="PISWVPI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0135906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG62102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="351" mass="40441" checksum="D67CF0C78AB05CDE" modified="2004-07-19" version="1">MTTIIPLLKQYSAPVFERYPVLHNYVPTVEKPFFNINLWENFDHFVTLATNGKFIPSEFQFVAGELPLSELQPVLIAIATYYIVIFGGKFVLSYSKPFKLNGLFQLHNLFLTTISLTLLVLMVEQLTPMIYHHGLFYAICNEGAWTQPMVTLYYMNYIVKFIEFIDTLFLVLKHKKLTFLHTYHHGATALLCYTQLVGTTSISWVPISLNLGVHVVMYWYYFLAARGIRVWWKEWVTRFQIIQFILDIGFIYFAVYQKATHLYFPTLPHCGECVGSTTATFAGCAIISSYLVLFISFYINVYKRKGSKASRVVKRVHGGVAAKVNEYVNVDLQNVSTPSPSPVAKDRRRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKX0</accession>
    <name>Q6FKX0_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0L08008g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62094.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKX0"/>
    <dbReference type="FunCoup" id="Q6FKX0">
        <property type="interactions" value="114"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890550"/>
    <dbReference type="CGD" id="CAL0135720">
        <property type="gene designation" value="CAGL0L08008g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08008g"/>
    <dbReference type="eggNOG" id="ENOG502SFZ7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_219858_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKX0"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012589">
        <property type="entry name" value="Pmp1/Pmp2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08114">
        <property type="entry name" value="PMP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0135720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62094.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="39" mass="4429" checksum="A43A23764F462CD2" modified="2008-09-23" version="2">MLPGGVILVFILVGLAACAIVAVIIYRKWQERQRSLQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKX6</accession>
    <name>Q6FKX6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L07832g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKX6"/>
    <dbReference type="FunCoup" id="Q6FKX6">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKX6"/>
    <dbReference type="KEGG" id="cgr:2891007"/>
    <dbReference type="CGD" id="CAL0135770">
        <property type="gene designation" value="CAGL0L07832g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07832g"/>
    <dbReference type="eggNOG" id="KOG4829">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086740_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKX6"/>
    <dbReference type="OMA" id="ISKWNTQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="89"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0135770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG62088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="275" mass="33048" checksum="DA0D0663CF3BEBD2" modified="2004-07-19" version="1">MDHVPAWKRFAIKNKNEGKREIEDDPLNVTTHLATGSLTKKQKKSILNGTDNDLPKKVKNKDKKQKKAKLPREERLEKKQRVLKDQLRYLIEFYLKDSDELPDKLYQLESIRSNYDENDIKSKKDESAVVDVWKFSKQKQNWLLKHFHNFDEIPAEYDELLLNYFKDMKGRSKYELIKLCNEKLETWNKYIAEQEEKMQKIINGEENEDNKNVEQNEENKEDEEQKHKVEELPMPNKAVICRSYKLLSLWEKNKNEDEQDFEVVILQKFPEEDLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-11-22" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKZ2</accession>
    <name>SLT11_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SLT11</name>
        <name type="ordered locus">CAGL0L07458g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKZ2"/>
    <dbReference type="SMR" id="Q6FKZ2"/>
    <dbReference type="FunCoup" id="Q6FKZ2">
        <property type="interactions" value="180"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKZ2"/>
    <dbReference type="EnsemblFungi" id="CAGL0L07458g-T">
        <property type="protein sequence ID" value="CAGL0L07458g-T-p1"/>
        <property type="gene ID" value="CAGL0L07458g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890990"/>
    <dbReference type="CGD" id="CAL0136050">
        <property type="gene designation" value="CAGL0L07458g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07458g"/>
    <dbReference type="eggNOG" id="KOG0153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027112_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FKZ2"/>
    <dbReference type="OMA" id="RNVCQCC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0508">mRNA splicing</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0747">Spliceosome</keyword>
    <feature type="chain" id="PRO_0000212424" description="Pre-mRNA-splicing factor SLT11">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="364" mass="41454" checksum="EF619789BD2A4662" modified="2004-07-19" version="1">MNKLILGSEEVPQICEKCLGTSNTNENIRMNEVPNGAACKICTLPYTLYHFKKSHRSADIIKTLICKKCAIQRNVCQCCMLDMKLHISIQLRDKLMSIVSGKETITEEAKNIMMKKFIAMKGGSLGSADLTRNVDSIEDILLNLREKLEGKPLNDENEPISALQNKELGDNPHLKSVDIQPYWDKFPLQETFPNAIQIPKGNDSFKSFFIYNIDSSVPEWKISDKITELLGSDSWKTKESIPIIINHKAMCGAFRIGNNELSEKFLQTINNSDNMIRINRSNGLRRGILKVDHFQLFIIPWKQGFSVESFGRTPNESKKIAFALREIIVEEMGGFKDKNDRCKAKEKPKKITKKSKKRVKSIKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL09</accession>
    <name>NUR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Nuclear rim protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NUR1</name>
        <name type="ordered locus">CAGL0L07084g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NUR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449085.1">
        <property type="nucleotide sequence ID" value="XM_449085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL09"/>
    <dbReference type="FunCoup" id="Q6FL09">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL09"/>
    <dbReference type="EnsemblFungi" id="CAGL0L07084g-T">
        <property type="protein sequence ID" value="CAGL0L07084g-T-p1"/>
        <property type="gene ID" value="CAGL0L07084g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890830"/>
    <dbReference type="KEGG" id="cgr:2890830"/>
    <dbReference type="CGD" id="CAL0136192">
        <property type="gene designation" value="CAGL0L07084g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L07084g"/>
    <dbReference type="eggNOG" id="ENOG502S7S0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625555_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL09"/>
    <dbReference type="OMA" id="LENTHWS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000409028" description="Nuclear rim protein 1">
        <location>
            <begin position="1"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="438" mass="51561" checksum="8FDA3BB3FA7A6B7D" modified="2004-07-19" version="1">MFSWLIPDIPELFLTISVWFRLQGWEDNTKLGFIIGNTLTTIFYILRLAQDTLLAGVSRKLIRDYELFDLSKSETLLSDPAFSSYHDVLFNKHHSTANASSYNKRVRKVTSTVYWSTYFLLLLSCYTCYRLFNTYKVYRIYYLKDLNLDKHPSLKKIEPDYEVDEKLLKTSLKSKLLSRFIRLLQLQDEVETELPKVTEHYTLNKWDPSKLIISLSTSFSPTIIICLMYTNVTFLTVIPIIIHQGIFYFMIWNRYEERFKDDALLMRENYLQYDTKYVKPLKQIMYQDVMTDTATISDGGFTKFFPVSKSTLFKHHEMSGDVIIERYNKKSREFENVTDIIKPHHHINNTVKILPPTIRKDHKTNRYDHRQQSILKDRKFNIDSNEPQIINALTTAIPSRSFFNNNPSGSNDDNCSGIKVRSSPTRETFFPATPLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL48</accession>
    <name>Q6FL48_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L06226g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449046.1">
        <property type="nucleotide sequence ID" value="XM_449046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL48"/>
    <dbReference type="STRING" id="284593.Q6FL48"/>
    <dbReference type="KEGG" id="cgr:2890754"/>
    <dbReference type="CGD" id="CAL0135702">
        <property type="gene designation" value="CAGL0L06226g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L06226g"/>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567395_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FL48"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="147"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="381"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="439"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="481" mass="54855" checksum="841E19055FD885AE" modified="2004-07-19" version="1">MDLESQVRLRCLYSKEEFYALKIIYPDWRNRINNIPKFDNRSRTAKPNSIQTAKRNHEVPNGNSVVKKKFASAVTVKNTKEDEYLRDYVITLTGSINDVSLGLLNLLIMVNNPKVTRIIDSVEKPFLKRLLIRADPTFFNNVNDIKKLSFIRMLVSNTNLSKVLGSEGHRIADLRDKYDLRMKASKYKLSQSTDRVFEIEGLAQNIIEALVEINNIILREKTTNSEQVSQVEYEPTPIKPNKKKKRSKKKTKKPNGDSIQGKSSTQEGVDRSESNLSEKKRDNSNQNKNDTGSDSASMSKTIISPKEAHDQNNTPELQTSNHSKRAVSNEQTQEHNTLQKVSSQRSLNSNHSRKTSDSSTASKTLLLHTSGTDTIISSDQQMFVDIILIPEGYVGRLVGKGGSRLANLRKFTRTKILIDERGSKDESKYRKFTITSSDEKNVQRAKALLQANLVEEQRRDREKLENKIKKHLLNENNEEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL75</accession>
    <name>Q6FL75_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0L05610g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL75"/>
    <dbReference type="FunCoup" id="Q6FL75">
        <property type="interactions" value="1452"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890798"/>
    <dbReference type="CGD" id="CAL0136116">
        <property type="gene designation" value="CAGL0L05610g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05610g"/>
    <dbReference type="eggNOG" id="ENOG502QRFX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_42_4_1"/>
    <dbReference type="InParanoid" id="Q6FL75"/>
    <dbReference type="OMA" id="ETGKYPL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0136116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="531" mass="60327" checksum="FB86FFC51391EB70" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLQ5</accession>
    <name>AIM32_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM32</name>
        <name type="ordered locus">CAGL0L01529g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448839.1">
        <property type="nucleotide sequence ID" value="XM_448839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLQ5"/>
    <dbReference type="SMR" id="Q6FLQ5"/>
    <dbReference type="FunCoup" id="Q6FLQ5">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLQ5"/>
    <dbReference type="EnsemblFungi" id="CAGL0L01529g-T">
        <property type="protein sequence ID" value="CAGL0L01529g-T-p1"/>
        <property type="gene ID" value="CAGL0L01529g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890881"/>
    <dbReference type="KEGG" id="cgr:2890881"/>
    <dbReference type="CGD" id="CAL0135706">
        <property type="gene designation" value="CAGL0L01529g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01529g"/>
    <dbReference type="eggNOG" id="ENOG502QS3W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044499_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FLQ5"/>
    <dbReference type="OMA" id="IPEMKIY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF7">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000399694" description="Altered inheritance of mitochondria protein 32">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="313" mass="35477" checksum="BFCD55629E3CB9C2" modified="2004-07-19" version="1">MVIGNRVLLPLTKRYYNARYRKVLHPELREEIIAHNCYCEEVNSKLHFDDEKIDPGISLKTAVPSYDKHVMLISDINRGMAKKPGVWKNIWESRIENNTTHPYDIISKLNFGPGVLFNAISITSSLESFAPTSLEFYDFLVMPDMRYYRVKKPDIEKFSQYINSGHAVAPKLSFSDYLSGKAAATTVSNNNQITLSLDDSIYYRELKNDAWLFVCGHEKRDMRCGIMGPEILHSVNTANSKPLVNNTGIISHIGGHKFAGNILIYKPIENQNGRKKVDSLWFGKVTPFNVSEIVQSVNEGVIIENNFRGGLSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-05-18" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLR5</accession>
    <name>ENOPH_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase-phosphatase E1</fullName>
            <ecNumber evidence="1">3.1.3.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">UTR4</name>
        <name type="ordered locus">CAGL0L01287g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.77" evidence="1"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448829.1">
        <property type="nucleotide sequence ID" value="XM_448829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLR5"/>
    <dbReference type="SMR" id="Q6FLR5"/>
    <dbReference type="FunCoup" id="Q6FLR5">
        <property type="interactions" value="680"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLR5"/>
    <dbReference type="EnsemblFungi" id="CAGL0L01287g-T">
        <property type="protein sequence ID" value="CAGL0L01287g-T-p1"/>
        <property type="gene ID" value="CAGL0L01287g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890920"/>
    <dbReference type="KEGG" id="cgr:2890920"/>
    <dbReference type="CGD" id="CAL0135438">
        <property type="gene designation" value="UTR4"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_L01287g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L01287g"/>
    <dbReference type="eggNOG" id="KOG2630">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023273_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FLR5"/>
    <dbReference type="OMA" id="LQGMVWE"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00876"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00877"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03117">
        <property type="entry name" value="Salvage_MtnC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027511">
        <property type="entry name" value="ENOPH1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000393995" description="Enolase-phosphatase E1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03117"/>
        </source>
    </evidence>
    <sequence length="251" mass="28315" checksum="A06173CEE4374B21" modified="2004-07-19" version="1">MSPDPKYSAYLLDIEGTLCPLSFVKDTLYPFFVLHVQRIVYENFNEEHPKDEFIAEQLAKYDIKEEGQAGKNKLVEHLLDLVANDTKDSTLKALQGHVWEVGYNSGELEVPLYPDVIDFLVRNDGRGDDKVPVYIYSSGSIHAQKLLFGHVKNSGNSHAKIAGNWDLNRFIDGYFDINTAGKKTESNSYKKILDEIKMTDKPHDVLFLSDNAKELDAAKECGISVGLAMRAGNVTVPNAIDYKQYFQFTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLU1</accession>
    <name>Q6FLU1_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FCY21</name>
        <name evidence="11 12" type="ordered locus">CAGL0L00671g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448803.1">
        <property type="nucleotide sequence ID" value="XM_448803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLU1"/>
    <dbReference type="FunCoup" id="Q6FLU1">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLU1"/>
    <dbReference type="GeneID" id="2890925"/>
    <dbReference type="KEGG" id="cgr:2890925"/>
    <dbReference type="CGD" id="CAL0135760">
        <property type="gene designation" value="FCY21"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L00671g"/>
    <dbReference type="eggNOG" id="ENOG502QQ8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026016_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FLU1"/>
    <dbReference type="OMA" id="LWLSANM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015856">
        <property type="term" value="P:cytosine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11484">
        <property type="entry name" value="SLC-NCS1sbd_CobB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0135760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="543" mass="59681" checksum="8138B2A4B5837F04" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLV8</accession>
    <name>Q6FLV8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0L00297g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FLV8">
        <property type="interactions" value="710"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLV8"/>
    <dbReference type="KEGG" id="cgr:2890922"/>
    <dbReference type="CGD" id="CAL0136154">
        <property type="gene designation" value="CAGL0L00297g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L00297g"/>
    <dbReference type="eggNOG" id="KOG1932">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002317_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FLV8"/>
    <dbReference type="OMA" id="TDLFMKK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 Ig-like" evidence="9">
        <location>
            <begin position="627"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 2 TPR repeats" evidence="10">
        <location>
            <begin position="814"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0136154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1385" mass="159276" checksum="7566C1DD2278A5AC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLW8</accession>
    <name>Q6FLW8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein FMP32, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0K12870g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLW8"/>
    <dbReference type="FunCoup" id="Q6FLW8">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890120"/>
    <dbReference type="CGD" id="CAL0133961">
        <property type="gene designation" value="CAGL0K12870g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12870g"/>
    <dbReference type="eggNOG" id="KOG3156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063283_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FLW8"/>
    <dbReference type="OMA" id="MAYMRFR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000214">
        <property type="term" value="P:regulation of L-proline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0133961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23877" checksum="32EF0CA16093AFBF" modified="2004-07-19" version="1">MNRYIGLGVRRHFHTLSPLFNSFKPIHVSNTHKYKQILTDKNAFTEAQASMIVELMVDAVRDGVEHVSKDLAMREKLTQLAYQQRVDFAKLRDQLLSADRSEFHNLQNEYEGVRNDLEKLRNKLREEITKANAGFKLDLSLEKGRIREENSHYELQIKEIDTRIDQEVNNIKMQIDSVKTQVMQWLIGVCTGTFALILAYVRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM24</accession>
    <name>Q6FM24_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar ATPase assembly integral membrane protein VPH2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">VPH2</name>
        <name evidence="7 8" type="ordered locus">CAGL0K11594g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448720.1">
        <property type="nucleotide sequence ID" value="XM_448720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM24"/>
    <dbReference type="FunCoup" id="Q6FM24">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="GeneID" id="2890523"/>
    <dbReference type="KEGG" id="cgr:2890523"/>
    <dbReference type="CGD" id="CAL0134825">
        <property type="gene designation" value="VPH2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K11594g"/>
    <dbReference type="eggNOG" id="ENOG502RZXR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091774_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM24"/>
    <dbReference type="OMA" id="WYWTGSS"/>
    <dbReference type="PHI-base" id="PHI:8796"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23377" checksum="E69029EC87EF515B" modified="2004-07-19" version="1">MFEVAVGSALRRALESAVEAAVAAGDGDAKVRLLELIERGSVPCGELAELCRAWGSEVSVSEALSGLEFKFKDRETRKPSPEFQAQLARLRALQQEQEYQQIVKNRDLAITTESEATPAQINREIKEQVTTVFNIIISVISVVVAIWYWSRTSAGLAIHHRIFLCMFFGILVLVAEVVVYSSYLSKIEEAKASEKSKKEHKKLVQKYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM82</accession>
    <name>Q6FM82_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0K10186g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM82"/>
    <dbReference type="FunCoup" id="Q6FM82">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM82"/>
    <dbReference type="KEGG" id="cgr:2890112"/>
    <dbReference type="CGD" id="CAL0134817">
        <property type="gene designation" value="CAGL0K10186g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10186g"/>
    <dbReference type="eggNOG" id="ENOG502RTRR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053754_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM82"/>
    <dbReference type="OMA" id="TIHELKC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042275">
        <property type="term" value="P:error-free postreplication DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030491">
        <property type="term" value="P:heteroduplex formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903112">
        <property type="term" value="P:positive regulation of single-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="14"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="337" mass="38310" checksum="E90E7E9E527FF0D1" modified="2004-07-19" version="1">MSFGVPLSQLIVNAPKPISTGLTALDNELDGGFRYKSSYEIYGIPGIGKTWLASETVKTYLQENDDGKVLWITTSGVAPQMLLRSEAEVKERIEYIRITKFTELLYFYQKQVMSEPDSISQSQSPAESAMPSTGTEAITNDTNSNDSYRLVIIDGLSRLLNLQLHSLSKKNCTTLHDTKCRYLIILMTLITKYNNKNNACHVILNDSMNTTYVPENNGGAEDELEMVEDGFNFFVKSHNYLYENNKRRRVYAPNVIRSALVANNALGNRDSRWEIFIKRRIGIFWEWEDKVTRNLDTECSKKATGNGRCRVALVHKDRQKSSQSLNFSVVPFDIDLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-06-28" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM84</accession>
    <name>SHU2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Suppressor of hydroxyurea sensitivity protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SHU2</name>
        <name type="ordered locus">CAGL0K10142g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase. Required for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHU2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448660.1">
        <property type="nucleotide sequence ID" value="XM_448660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM84"/>
    <dbReference type="SMR" id="Q6FM84"/>
    <dbReference type="FunCoup" id="Q6FM84">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM84"/>
    <dbReference type="EnsemblFungi" id="CAGL0K10142g-T">
        <property type="protein sequence ID" value="CAGL0K10142g-T-p1"/>
        <property type="gene ID" value="CAGL0K10142g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890110"/>
    <dbReference type="KEGG" id="cgr:2890110"/>
    <dbReference type="CGD" id="CAL0134723">
        <property type="gene designation" value="CAGL0K10142g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10142g"/>
    <dbReference type="eggNOG" id="ENOG502S0XB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1115918_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM84"/>
    <dbReference type="OMA" id="WLKLHLN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000409732" description="Suppressor of hydroxyurea sensitivity protein 2">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="255" mass="29130" checksum="F3E1B6578733D6DB" modified="2004-07-19" version="1">MNEDASVINYSEIFSTLVKDDGVDDMVASFLYYMFPRELFIRGLSLLESSDMFIYVFDAMKGESSESEVNTDVDTSVNLSSKENIATSTTATQINAKDNSVDVTKNYLNKLYEDDDLLQYRLIVKSSSSDGIETPVYVDLHNWLCSCEEYTEIMRECLLADKDLVQEFVQLIDDFSCFRDDTFGQIEAHSLSLQKYVNTKKLLCPHLLAYSIILLSSPKVLRHYTVEKPGVIVIPITSIDEWLKLHINVLYSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMN5</accession>
    <name>Q6FMN5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0K06567g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMN5"/>
    <dbReference type="FunCoup" id="Q6FMN5">
        <property type="interactions" value="1259"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMN5"/>
    <dbReference type="KEGG" id="cgr:2890441"/>
    <dbReference type="CGD" id="CAL0134711">
        <property type="gene designation" value="CAGL0K06567g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06567g"/>
    <dbReference type="eggNOG" id="KOG3418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067359_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FMN5"/>
    <dbReference type="OMA" id="NQWFFTK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="8"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0134711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="136" mass="15560" checksum="28684BD6DAEC2B7C" modified="2004-07-19" version="1">MAKFLKAGKVAVVVRGRYAGKKVVIVKPHDEGSKAHPFAHALVAGIERYPLKVTKKHGAKKVAKRTKIKPFIKAINYNHLLPTRYTLDVESFKSVVSTETFEEPTQREEAKKVIKKAFEERHQAGKNQWFFSKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMW8</accession>
    <name>Q6FMW8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vitamin H transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VHT1</name>
        <name evidence="9 10" type="ordered locus">CAGL0K04609g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448426.1">
        <property type="nucleotide sequence ID" value="XM_448426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMW8"/>
    <dbReference type="FunCoup" id="Q6FMW8">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMW8"/>
    <dbReference type="KEGG" id="cgr:2890005"/>
    <dbReference type="CGD" id="CAL0134681">
        <property type="gene designation" value="VHT1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04609g"/>
    <dbReference type="eggNOG" id="KOG2533">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_4_2_1"/>
    <dbReference type="InParanoid" id="Q6FMW8"/>
    <dbReference type="OMA" id="CAILIKW"/>
    <dbReference type="PHI-base" id="PHI:11471"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006768">
        <property type="term" value="P:biotin metabolic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF31">
        <property type="entry name" value="VITAMIN H TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="542"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="70527" checksum="CA838DB3F38AA0ED" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN72</accession>
    <name>NSA2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Ribosome biogenesis protein NSA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NSA2</name>
        <name type="ordered locus">CAGL0K02233g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the pre-66S ribosomal particle. Interacts with NOP7 and RRP1. Interacts with RSA4 (via WD repeats).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448322.1">
        <property type="nucleotide sequence ID" value="XM_448322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN72"/>
    <dbReference type="SMR" id="Q6FN72"/>
    <dbReference type="FunCoup" id="Q6FN72">
        <property type="interactions" value="1312"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN72"/>
    <dbReference type="EnsemblFungi" id="CAGL0K02233g-T">
        <property type="protein sequence ID" value="CAGL0K02233g-T-p1"/>
        <property type="gene ID" value="CAGL0K02233g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890299"/>
    <dbReference type="KEGG" id="cgr:2890299"/>
    <dbReference type="CGD" id="CAL0134657">
        <property type="gene designation" value="CAGL0K02233g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K02233g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02233g"/>
    <dbReference type="eggNOG" id="KOG3163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1070048_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN72"/>
    <dbReference type="OMA" id="TNTPEND"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <feature type="chain" id="PRO_0000320413" description="Ribosome biogenesis protein NSA2">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal 1" evidence="3">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal 2" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P40078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="261" mass="29645" checksum="D89709755A30FA4B" modified="2004-07-19" version="1">MPQNDYIERHIKQHGRRLDYEERKRKREAREVHKVAEKAQKLTGWKGKQFAKKRYAEKVAMRKKIKAHEQSKAKGSSKPLADNGEALPTYLLDREQTNTAKAISSSIKQKRLEKADKFSVPLPKVRGISEEEMFKVVKTGKSKSKSWKRMITKHTFVGEGFTRRPVKMERIIRPSALRQKKANVTHPELGVTVFLPILGVKKNPQSPMYTQLGVLTKGTIIEVNVSELGMVTSGGKVVWGKYAQITNEPDRDGCVNAILLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNA1</accession>
    <name>Q6FNA1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0K01573g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNA1"/>
    <dbReference type="FunCoup" id="Q6FNA1">
        <property type="interactions" value="1342"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNA1"/>
    <dbReference type="KEGG" id="cgr:2890019"/>
    <dbReference type="CGD" id="CAL0134659">
        <property type="gene designation" value="CAGL0K01573g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01573g"/>
    <dbReference type="eggNOG" id="KOG2636">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027160_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FNA1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031590">
        <property type="entry name" value="PRP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16958">
        <property type="entry name" value="PRP9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="516" mass="60811" checksum="1C2B23241D14626E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNP2</accession>
    <name>Q6FNP2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">YL15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RPL16A</name>
        <name evidence="11 12" type="ordered locus">CAGL0J10164g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNP2"/>
    <dbReference type="FunCoup" id="Q6FNP2">
        <property type="interactions" value="1138"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNP2"/>
    <dbReference type="KEGG" id="cgr:2889412"/>
    <dbReference type="CGD" id="CAL0133306">
        <property type="gene designation" value="RPL16A"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10164g"/>
    <dbReference type="eggNOG" id="KOG3204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076922_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNP2"/>
    <dbReference type="OMA" id="TRFNKTH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4280:FF:000001">
        <property type="entry name" value="60S ribosomal protein L16-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0133306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG61103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="200" mass="22496" checksum="A768FBEB4169F098" modified="2004-07-19" version="1">MSTFEKVVVIDAKGHLVGRLASIVAKQLLNGQKIVVVRAEALNISGEFFRNKLKYHDFLRKATAFNKTRGPFHFRAPSRIFYKAVRGMISHKTARGKAALERLKVFEGVPPPYDKKKRVVVPEALRVLRLKPGRKYTTLAKLSTSVGWKYEDVVAKLEEKRKVRSAEYYAKKRAFNKKVTAATASAAETDAAKKLATLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP09</accession>
    <name>Q6FP09_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">P/Homo B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">KEX2</name>
        <name evidence="20 21" type="ordered locus">CAGL0J07546g</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S8 family. Furin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448035.1">
        <property type="nucleotide sequence ID" value="XM_448035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP09"/>
    <dbReference type="FunCoup" id="Q6FP09">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP09"/>
    <dbReference type="MEROPS" id="S08.070"/>
    <dbReference type="GeneID" id="2889598"/>
    <dbReference type="KEGG" id="cgr:2889598"/>
    <dbReference type="CGD" id="CAL0133116">
        <property type="gene designation" value="KEX2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J07546g"/>
    <dbReference type="eggNOG" id="KOG3525">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002976_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FP09"/>
    <dbReference type="OMA" id="AYEFDII"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071852">
        <property type="term" value="P:fungal-type cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007323">
        <property type="term" value="P:peptide pheromone maturation"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04059">
        <property type="entry name" value="Peptidases_S8_Protein_convertases_Kexins_Furin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000026">
        <property type="entry name" value="proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000005">
        <property type="entry name" value="Proprotein convertase subtilisin/kexin type 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034182">
        <property type="entry name" value="Kexin/furin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002884">
        <property type="entry name" value="P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884:SF14">
        <property type="entry name" value="NEUROENDOCRINE CONVERTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42884">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01483">
        <property type="entry name" value="P_proprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51829">
        <property type="entry name" value="P_HOMO_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 15" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273471" description="P/Homo B domain-containing protein" evidence="18">
        <location>
            <begin position="24"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="P/Homo B" evidence="19">
        <location>
            <begin position="467"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="606"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="764"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="627"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="14 15">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="14 15">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="14 15">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0133116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG60986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="789" mass="87773" checksum="879F435D11D93FDF" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP56</accession>
    <name>Q6FP56_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0J06490g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP56"/>
    <dbReference type="STRING" id="284593.Q6FP56"/>
    <dbReference type="KEGG" id="cgr:2889540"/>
    <dbReference type="CGD" id="CAL0133664">
        <property type="gene designation" value="CAGL0J06490g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06490g"/>
    <dbReference type="eggNOG" id="ENOG502SDIE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1703984_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP56"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14424">
        <property type="entry name" value="CUE_Cue1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274125" description="CUE domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0133664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="154" mass="17698" checksum="081C2B99FDC00B3F" modified="2004-07-19" version="1">MDLSTKVFLGLLVAFILVVKRYLNQPTHKNINKTVDISNDGEEIDKDVLVSGKDQKTVKRRRKRRVTEGMIEIVSTLAPHLDVEQIKYDLEKTGSVELTVERLLKGEEFEFPPKEDESSTANNSKSNEEPQNEEDYYEDYHTETDSSDSEDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPG3</accession>
    <name>Q6FPG3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0J04048g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPG3"/>
    <dbReference type="FunCoup" id="Q6FPG3">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPG3"/>
    <dbReference type="KEGG" id="cgr:2889643"/>
    <dbReference type="CGD" id="CAL0132910">
        <property type="gene designation" value="CAGL0J04048g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04048g"/>
    <dbReference type="eggNOG" id="KOG3361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FPG3"/>
    <dbReference type="OMA" id="YMTERVR"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000005">
        <property type="entry name" value="Iron-sulfur cluster assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0132910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="145" mass="16025" checksum="519727B449868DA6" modified="2004-07-19" version="1">MFLRSTRLMRPFTRMYHPKVIEHYTNPRNVGSMDKTLRNVGTGVVGAPACGDVIKLQIQVNDNTGVIEEAKFKTFGCGSAIASSSYLTELVQGITIEDAEKIKNIEIAKELSLPPVKLHCSMLAEDAIKAAVRDYKTKRSSTTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPM3</accession>
    <name>Q6FPM3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ergosterol biosynthetic protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ERG28</name>
        <name evidence="14 15" type="ordered locus">CAGL0J02684g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPM3"/>
    <dbReference type="FunCoup" id="Q6FPM3">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPM3"/>
    <dbReference type="KEGG" id="cgr:2889532"/>
    <dbReference type="CGD" id="CAL0133236">
        <property type="gene designation" value="ERG28"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J02684g"/>
    <dbReference type="eggNOG" id="KOG3455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114589_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPM3"/>
    <dbReference type="OMA" id="NIAIWTY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0133236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG60770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16861" checksum="6141385B9D5530E7" modified="2004-07-19" version="1">MLSLQQLTGGVHSAVTNMAPGYLPKWLLFISIVSVFNSVQTYISGLELTRRVYENKPSETTSLSARTFGTWTFVSCVIRFYGALYITEPHIYQLTFISYIIALFHFGSELLIFRTCKLGKGFMGPLIVASTSLIWMYNQKEYYTGLPW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-08-16" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPT9</accession>
    <name>SNX4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">SNX4</name>
        <name type="synonym">ATG24</name>
        <name type="ordered locus">CAGL0J01001g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), and autophagy of large cargos including mitophagy, pexophagy and glycophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Endosome and other perivacuolar punctate structures. Associates to phosphatidylinositol 3-phosphate, necessary for peripheral membrane localization to the perivacuolar punctate structures.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447755.1">
        <property type="nucleotide sequence ID" value="XM_447755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPT9"/>
    <dbReference type="SMR" id="Q6FPT9"/>
    <dbReference type="FunCoup" id="Q6FPT9">
        <property type="interactions" value="578"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPT9"/>
    <dbReference type="EnsemblFungi" id="CAGL0J01001g-T">
        <property type="protein sequence ID" value="CAGL0J01001g-T-p1"/>
        <property type="gene ID" value="CAGL0J01001g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889847"/>
    <dbReference type="KEGG" id="cgr:2889847"/>
    <dbReference type="CGD" id="CAL0133242">
        <property type="gene designation" value="CAGL0J01001g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J01001g"/>
    <dbReference type="eggNOG" id="KOG2273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027221_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPT9"/>
    <dbReference type="OMA" id="WSLHRFI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010009">
        <property type="term" value="C:cytoplasmic side of endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036010">
        <property type="term" value="P:protein localization to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-0175">Coiled coil</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0967">Endosome</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000213809" description="Sorting nexin-4">
        <location>
            <begin position="1"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="33"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="351"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)</name>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P47057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q3UR97"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="Q6P4T1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q96L94"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="5"/>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="8"/>
    <sequence length="430" mass="49222" checksum="7525E131263CAA6C" modified="2004-07-19" version="1">MDSASADASVTGSGNAKGSSAERVNGGGKFYKLEILVSDPQKRAGEAGLGPYVSYQISTRTDNPSYHGNQKASFDDIIVVHRRYNDVVLLHDILQNDHPTCIIPPLPDKKVLQYIAGDRFGRRFTQRRCHSLQNFLRRVSQHPILSTSKVLEIFLVGNEWDTYRKNIAGTLQNAQKEDVTDAVMNAFKKVHNQNEEFTEIRDRSDKLDNSVNRINKVFHRVVKKNEAIIEDYSKLGLTLQELQELVSSDNDKLADSLKVFIEGVTQFSYGLQDLNMFIDYEYLIDLKDLSHYIGSMKQTMRLKDQKQIDYEELSDYLTKSIKEKNNLISGYGGGNFLTSKLEELAGYNQEASRRDKINKLESTISSLTTELETAKKVADTFEQETLKEVKKFEEIKNDELKISLNNLADENIKFYERMLETWEKVDQSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPW9</accession>
    <name>Q6FPW9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="10">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0J00319g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="10"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPW9"/>
    <dbReference type="FunCoup" id="Q6FPW9">
        <property type="interactions" value="458"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPW9"/>
    <dbReference type="KEGG" id="cgr:2889912"/>
    <dbReference type="CGD" id="CAL0133326">
        <property type="gene designation" value="CAGL0J00319g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J00319g"/>
    <dbReference type="eggNOG" id="KOG2951">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FPW9"/>
    <dbReference type="OMA" id="FNVMKPD"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071545">
        <property type="term" value="P:inositol phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000013">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000012">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0452">Lithium</keyword>
    <keyword evidence="8 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0133326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG60672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="294" mass="32618" checksum="21D9D5A7F0DB7F16" modified="2004-07-19" version="1">MDLLSIEKFLCDLSVNQVGPIIKKKSGTQHVYDLKTGERAVDIVTAIDKQVEKLIWDSLKEQYPDFKFVGEESYVKGVTTITDDPTFIVDPIDGTTNFVHDFPFSCTSLGLTINKEPVVGVIYNPHLDLLISASKGNGIRINREPFDHKAKLESMGPLYLNKSVVALQPGSAREGNNFKTKMKTYESLLSCDEGFVHGFRNLGSTAMTLAYIATGNLDSYWDGGCYSWDVCAGWCILKEAGGIIVGANPGEWDIPIDNRSYLAVRGTTEEGGKELQKKYVDDFWKCVKGKLSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ25</accession>
    <name>Q6FQ25_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0I09702g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447669.1">
        <property type="nucleotide sequence ID" value="XM_447669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ25"/>
    <dbReference type="FunCoup" id="Q6FQ25">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888942"/>
    <dbReference type="CGD" id="CAL0132528">
        <property type="gene designation" value="CAGL0I09702g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09702g"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ25"/>
    <dbReference type="OMA" id="CHVASMM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032218">
        <property type="term" value="P:riboflavin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="107"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0132528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="521" mass="57828" checksum="3157630C490F1879" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ93</accession>
    <name>SDHF2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="1">SDH assembly factor 2</shortName>
            <shortName evidence="1">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAGL0I08085g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This protein may be expected to contain an N-terminal transit peptide but none has been predicted.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ93"/>
    <dbReference type="SMR" id="Q6FQ93"/>
    <dbReference type="FunCoup" id="Q6FQ93">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ93"/>
    <dbReference type="EnsemblFungi" id="CAGL0I08085g-T">
        <property type="protein sequence ID" value="CAGL0I08085g-T-p1"/>
        <property type="gene ID" value="CAGL0I08085g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889290"/>
    <dbReference type="CGD" id="CAL0130464">
        <property type="gene designation" value="CAGL0I08085g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I08085g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08085g"/>
    <dbReference type="eggNOG" id="KOG3326">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103054_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FQ93"/>
    <dbReference type="OMA" id="YGKPQNP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018293">
        <property type="term" value="P:protein-FAD linkage"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383190" description="Succinate dehydrogenase assembly factor 2, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <sequence length="153" mass="18203" checksum="7596EC3367897F54" modified="2004-07-19" version="1">MLRITYKLPIALRQQAFVARKLVPTIKANYSTNSDDDVVSRIKVHPIKRINESIDKKRARLIYQSRKRGILETDLLLSGFAAKHLRSMTNEELDEYDALLNELDWDIYYWVTKNYKTSPVPERWKNSEILKKLQDFSENKEKKILRMPDLENY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-12-06" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQB2</accession>
    <name>TRM10_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA(m1G9)-methyltransferase</fullName>
            <shortName evidence="2">tRNA(m1G9)MTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TRM10</name>
        <name type="ordered locus">CAGL0I07667g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="2"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447582.1">
        <property type="nucleotide sequence ID" value="XM_447582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQB2"/>
    <dbReference type="SMR" id="Q6FQB2"/>
    <dbReference type="FunCoup" id="Q6FQB2">
        <property type="interactions" value="819"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQB2"/>
    <dbReference type="EnsemblFungi" id="CAGL0I07667g-T">
        <property type="protein sequence ID" value="CAGL0I07667g-T-p1"/>
        <property type="gene ID" value="CAGL0I07667g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889002"/>
    <dbReference type="KEGG" id="cgr:2889002"/>
    <dbReference type="CGD" id="CAL0132340">
        <property type="gene designation" value="CAGL0I07667g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_I07667g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07667g"/>
    <dbReference type="eggNOG" id="KOG2967">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034384_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FQB2"/>
    <dbReference type="OMA" id="FKKNDGW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016653">
        <property type="entry name" value="TRM10/TRM10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016323">
        <property type="entry name" value="tRNA_m1G_mtfrase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000060512" description="tRNA (guanine(9)-N1)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="3">
        <location>
            <begin position="79"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="203"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="O14214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q12400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="287" mass="33876" checksum="5D9C32BFB5AB7D41" modified="2004-07-19" version="1">MSDTSDLVDGKWQRLPPVPEGMSKSQWKKQWRRQMYEAKKEEYAEVRKEKRKRAKENRRKKIQEYIDRGEEVPAELKREPRVNRDQVASGINIILDCAFDDLMNDKEIVSTSNQITRAYSANRRASQYANITVTSFNKRLKERFDKALDDCNYPQWQNFKFVSDEKLITEGDKSKMVYLTADTEEQLDTLEPGMTYIVGGIVDKNRHKLLCYNKAKELGIPTRRLPIGEYIKIEGRKVLTTTHVIQLMLKYCESRDWKESFESVIPSRKLDPVKEKEQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQC6</accession>
    <name>Q6FQC6_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0I07315g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447568.1">
        <property type="nucleotide sequence ID" value="XM_447568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQC6"/>
    <dbReference type="FunCoup" id="Q6FQC6">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQC6"/>
    <dbReference type="KEGG" id="cgr:2889215"/>
    <dbReference type="CGD" id="CAL0132198">
        <property type="gene designation" value="CAGL0I07315g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07315g"/>
    <dbReference type="eggNOG" id="ENOG502QR7R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_11_1_1"/>
    <dbReference type="InParanoid" id="Q6FQC6"/>
    <dbReference type="OMA" id="QTYMFKE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033883">
        <property type="term" value="F:pyridoxal phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="217" mass="24581" checksum="2B7A481F17D0BAEA" modified="2004-07-19" version="1">MVTTKLRTFSKLPKVAAVIFDMDGTLCLPQPWMFPAMREAIGLKDASQDILDFISMMDDPVQQKIAEEGLAKVEEKAMLEMIPQPGLVETMKYLTQQGIAKNICTRNVGTPVHYFIDKFIPKDYAKFDHIIMRDFRPTKPYPDPLLHIAKQIDSNPQHIIMVGDSYDDMKSGRLAGCLTVLLKNKINAKLVEEQSSLIDVTISELNELIEIIEEINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQD0</accession>
    <name>Q6FQD0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">IDH2</name>
        <name evidence="16 17" type="ordered locus">CAGL0I07227g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447564.1">
        <property type="nucleotide sequence ID" value="XM_447564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQD0"/>
    <dbReference type="SMR" id="Q6FQD0"/>
    <dbReference type="FunCoup" id="Q6FQD0">
        <property type="interactions" value="977"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQD0"/>
    <dbReference type="GeneID" id="2889192"/>
    <dbReference type="KEGG" id="cgr:2889192"/>
    <dbReference type="CGD" id="CAL0129777">
        <property type="gene designation" value="IDH2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07227g"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FQD0"/>
    <dbReference type="OMA" id="VRPCRYY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045242">
        <property type="term" value="C:isocitrate dehydrogenase complex (NAD+)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="37"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0129777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG60501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="368" mass="39513" checksum="8562261B997DF442" modified="2004-07-19" version="1">MLGIRSFRLNARRFLATAQPSIGRFTGKPNPSTGKFTVSFIEGDGIGPEISSSVKRIFQAADVPVEWETCDVTPIFVNGLTTIPDPAVQSINKNLVALKGPLATPIGKGHRSLNLTLRKTFNLFANVRPAKSIEGFKTTYENVDLVLIRENTEGEYSGIEHLVSPGVVQSIKLITRDASERVIRYAYEYARAIGRPRLIVVHKSTIQRLADGLFVNVAKELAAEYPDIQLETELIDNTCLNVVSNPSSYTDAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHKVSIFEAVHGSAPDIAGQNKANPTALLLSSVMMLNHMGMTEHADRIEKAVLGTIAGGSEYRTGDLGGSASTTSFTDAIIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQD1</accession>
    <name>Q6FQD1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0I07205g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQD1"/>
    <dbReference type="FunCoup" id="Q6FQD1">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQD1"/>
    <dbReference type="KEGG" id="cgr:2889191"/>
    <dbReference type="CGD" id="CAL0132082">
        <property type="gene designation" value="CAGL0I07205g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I07205g"/>
    <dbReference type="eggNOG" id="ENOG502S0Z0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028632_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQD1"/>
    <dbReference type="OMA" id="PLEFYPQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902499">
        <property type="term" value="P:positive regulation of protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14307">
        <property type="entry name" value="UBA_RUP1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041970">
        <property type="entry name" value="Rup1_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0132082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="603" mass="68860" checksum="13012A4695A99128" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQL8</accession>
    <name>Q6FQL8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Casein kinase II subunit alpha</fullName>
            <shortName evidence="11">CK II alpha</shortName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CKA1</name>
        <name evidence="13 14" type="ordered locus">CAGL0I05192g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Phosphorylates YTA7 during S-phase to promote transcription of histones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447476.1">
        <property type="nucleotide sequence ID" value="XM_447476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQL8"/>
    <dbReference type="FunCoup" id="Q6FQL8">
        <property type="interactions" value="1214"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQL8"/>
    <dbReference type="GeneID" id="2889198"/>
    <dbReference type="KEGG" id="cgr:2889198"/>
    <dbReference type="CGD" id="CAL0132506">
        <property type="gene designation" value="CKA1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I05192g"/>
    <dbReference type="eggNOG" id="KOG0668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000288_70_4_1"/>
    <dbReference type="InParanoid" id="Q6FQL8"/>
    <dbReference type="OMA" id="ECHMIEW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007535">
        <property type="term" value="P:donor selection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060962">
        <property type="term" value="P:regulation of ribosomal protein gene transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006356">
        <property type="term" value="P:regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000459">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="40"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0132506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG60413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="373" mass="45106" checksum="A4C8C96C91A61E75" modified="2004-07-19" version="1">MRCRVWSEARVYSKVNNEKNEDYWNYEDAAVTWSNNVKDYEIEMKVGRGKYSEVFQGVQLASRKHIVIKMLKPVKKKKIRREIKILTNLSNEKNPPTAQEFNRDLYFSNRDENILKQIRPYIYELPHHGHENIIQLFDVIRDPISRTPALVFEHVNNMDFRVLYPKLSDIDIRYYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKQRKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFQKEPFFHGTSNTDQLVKIVRVLGSDDFEKYLIKYQITLPREFHDMDQYIRRPWYRFVNDQNRHLSDNEDVIDLLDNLLRYDHQERLTAKEAMGHPWFEPIRRAETKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQP2</accession>
    <name>Q6FQP2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Factor-induced gene 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I04664g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQP2"/>
    <dbReference type="FunCoup" id="Q6FQP2">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQP2"/>
    <dbReference type="KEGG" id="cgr:2889359"/>
    <dbReference type="CGD" id="CAL0132558">
        <property type="gene designation" value="CAGL0I04664g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04664g"/>
    <dbReference type="eggNOG" id="ENOG502QUDU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075335_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQP2"/>
    <dbReference type="OMA" id="YFGICVN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000753">
        <property type="term" value="P:cell morphogenesis involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000755">
        <property type="term" value="P:cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016509">
        <property type="entry name" value="Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007138">
        <property type="entry name" value="FIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33219" checksum="2A4B28036A589F0B" modified="2004-07-19" version="1">MITLSALFFIAKRMPRMIVLLLTFINIFLLVFLLVGCYSPSHINTYLSRFTFASDSTLYPMIKQSFTHNAKTTGFENVVVKVGYLRTCIDKVPRVYNMDNNSIATKCYSGKTIENESIYSDITLQLFNVPKSSQSSNTTTSTPVTLNLLELAQITAAKVVHPHLLIATVAFTVLEFIGMTYYLIPLLPFKNWINIYNIVLASLLLLLWTIGVMWEHVATRATAKLIPPASLGIIKSHRGRKAASMAWLIFSFQLINTILLWFLYIRDRKSEVSDLDLDLNYNFSTNSSMTEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQP7</accession>
    <name>Q6FQP7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAGL0I04554g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447447.2">
        <property type="nucleotide sequence ID" value="XM_447447.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQP7"/>
    <dbReference type="SMR" id="Q6FQP7"/>
    <dbReference type="FunCoup" id="Q6FQP7">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQP7"/>
    <dbReference type="KEGG" id="cgr:2889033"/>
    <dbReference type="eggNOG" id="KOG1752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FQP7"/>
    <dbReference type="OMA" id="CCLIRTV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004274796" description="Glutaredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="129"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="226" mass="24373" checksum="1DBA9CB1961A656A" modified="2004-07-19" version="1">MLTGVLFTILYFLSHFSGPSSADSAFRQVGPGSRNSKGGGNLGPPIMEAEMNGNTNNIEKAEAGNKAMDTTSNSGTSNENAQLPGSKDQTDSNSNSLSNKEGQEDAEEAADAEYSPAKEFQKLVKSAPIVIFSKSYCPFSKNLKKLLDKNYRLDPAYVAVEVDQHPNGDKLYSYIKKLTGRNTVPNLIANGDSKGGFDDMLALHNSNELESKLIEWGVGELQVSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQQ9</accession>
    <name>Q6FQQ9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="14">TC-AMP synthase</shortName>
            <ecNumber evidence="3 14">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 14">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0I04290g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 14"/>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQQ9"/>
    <dbReference type="FunCoup" id="Q6FQQ9">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQQ9"/>
    <dbReference type="KEGG" id="cgr:2889077"/>
    <dbReference type="CGD" id="CAL0132552">
        <property type="gene designation" value="CAGL0I04290g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04290g"/>
    <dbReference type="eggNOG" id="KOG3051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQQ9"/>
    <dbReference type="OMA" id="RTQRWKS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="50"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0132552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG60372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="422" mass="45981" checksum="F9904B1F0A60C2F4" modified="2004-07-19" version="1">MTLLHKLSTFCKMSQPLRTEVLKVDALSIVFPENAHIDGKLPEVNDAPSRDALLKAAHIIRDTEETVAFPTETVYGLGGSSLNDNSVRNIYKAKNRPSDNPLITHVSSIDQLNRKIYNDYEDGDILRNIPKIYHPLIEKLWPGPLTILLPIPPERNVSLSKLTTGDQPTFAVRIPANSIARALIALADTPIAAPSANASTRPSPTLASHVYHDLKGRIPLIIDGGACNVGVESTVVDGLCLPPALLRPGGFTYEDILHLGGESWRNCKVENKKTLSEGEKVRTPGMKYKHYAPSAKVIVLLPNDSDTQMQLIDKMKVFLSSHQPDIIDKKVAIMTTLKLTPILNEISLFASSNYKGTKTEFLVSELGASGEAIQANLFAALRKADETDNVDTIIVEGISETSEGLAVMNRLRKASGGNIVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR21</accession>
    <name>Q6FR21_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0I01606g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR21"/>
    <dbReference type="FunCoup" id="Q6FR21">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR21"/>
    <dbReference type="KEGG" id="cgr:2889322"/>
    <dbReference type="CGD" id="CAL0132502">
        <property type="gene designation" value="CAGL0I01606g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01606g"/>
    <dbReference type="eggNOG" id="ENOG502QTEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008472_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR21"/>
    <dbReference type="OMA" id="CHVNARE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="1">
        <location>
            <begin position="946"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0132502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1157" mass="134320" checksum="856BEB581A5AA179" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR43</accession>
    <name>Q6FR43_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PFY1</name>
        <name evidence="8 9" type="ordered locus">CAGL0I01078g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447301.1">
        <property type="nucleotide sequence ID" value="XM_447301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR43"/>
    <dbReference type="FunCoup" id="Q6FR43">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR43"/>
    <dbReference type="GeneID" id="2889332"/>
    <dbReference type="KEGG" id="cgr:2889332"/>
    <dbReference type="CGD" id="CAL0132372">
        <property type="gene designation" value="PFY1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I01078g"/>
    <dbReference type="eggNOG" id="KOG1755">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120772_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FR43"/>
    <dbReference type="OMA" id="QGQKFML"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070064">
        <property type="term" value="F:proline-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090338">
        <property type="term" value="P:positive regulation of formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000001">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF0">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01640">
        <property type="entry name" value="PROFILINPLNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0132372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="126" mass="13728" checksum="F54FC0AC26DEF21D" modified="2004-07-19" version="1">MSWQAYTDNLLATGKVDKAVIYSKAGDAVWATSGGLSLQANEISEIVQGFDNPTGLQSNGLHIQGQKFMLLRADDRSIYGRHDAEGVVCVRTKQTVLIAHYPPTVQAGEATKIVEQLADYLISVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR74</accession>
    <name>Q6FR74_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0I00396g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447270.1">
        <property type="nucleotide sequence ID" value="XM_447270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR74"/>
    <dbReference type="KEGG" id="cgr:2889315"/>
    <dbReference type="CGD" id="CAL0132324">
        <property type="gene designation" value="CAGL0I00396g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I00396g"/>
    <dbReference type="HOGENOM" id="CLU_2108716_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR74"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="115" mass="13436" checksum="62DCC2F5149C32EA" modified="2004-07-19" version="1">MILRSGLLRPDQVVPGYDSHRTLKKKRVERATIYLLLRTSISTNRSSEPRKVNKYNRWQRRSALQNSLGHFSEAMRFLFLEHSHKHSLYVRETLSLLSLLALVCHPPPEMRPKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR94</accession>
    <name>Q6FR94_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA/rRNA methyltransferase SpoU type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0H10406g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FR94">
        <property type="interactions" value="178"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FR94"/>
    <dbReference type="KEGG" id="cgr:2888520"/>
    <dbReference type="CGD" id="CAL0130134">
        <property type="gene designation" value="CAGL0H10406g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10406g"/>
    <dbReference type="eggNOG" id="KOG0839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005519_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FR94"/>
    <dbReference type="OMA" id="VTADRWM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000022">
        <property type="entry name" value="Trm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="3">
        <location>
            <begin position="1270"/>
            <end position="1412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0130134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG60183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1420" mass="162224" checksum="25122D9C493EB9F7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FR97</accession>
    <name>Q6FR97_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0H10340g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447247.1">
        <property type="nucleotide sequence ID" value="XM_447247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FR97"/>
    <dbReference type="ESTHER" id="canga-q6fr97">
        <property type="family name" value="Duf_676"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888783"/>
    <dbReference type="CGD" id="CAL0130410">
        <property type="gene designation" value="CAGL0H10340g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H10340g"/>
    <dbReference type="eggNOG" id="KOG4372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007367_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FR97"/>
    <dbReference type="OMA" id="ARFWHED"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="171"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0130410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="592" mass="67860" checksum="D72D66225FAC2328" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="142" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRE6</accession>
    <name>Q6FRE6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PEX1</name>
        <name evidence="15 16" type="ordered locus">CAGL0H09174g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447198.1">
        <property type="nucleotide sequence ID" value="XM_447198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRE6"/>
    <dbReference type="FunCoup" id="Q6FRE6">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRE6"/>
    <dbReference type="GeneID" id="2888733"/>
    <dbReference type="KEGG" id="cgr:2888733"/>
    <dbReference type="CGD" id="CAL0132046">
        <property type="gene designation" value="PEX1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H09174g"/>
    <dbReference type="eggNOG" id="KOG0735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FRE6"/>
    <dbReference type="OMA" id="LCYNAYL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904949">
        <property type="term" value="C:ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140318">
        <property type="term" value="F:protein transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0000266"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="418"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="711"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1010"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0132046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG60131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1031" mass="114253" checksum="6AAF1B87C2D3C842" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRL0</accession>
    <name>Q6FRL0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H07733g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRL0"/>
    <dbReference type="FunCoup" id="Q6FRL0">
        <property type="interactions" value="273"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRL0"/>
    <dbReference type="KEGG" id="cgr:2888459"/>
    <dbReference type="CGD" id="CAL0131996">
        <property type="gene designation" value="CAGL0H07733g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07733g"/>
    <dbReference type="eggNOG" id="KOG2777">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005382_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FRL0"/>
    <dbReference type="OMA" id="KILHDCH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0131996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="385" mass="44232" checksum="93ECD55745B986A2" modified="2004-07-19" version="1">MSFRDDYGTKITELVLSEYEKLSAKGRPVTRSNGAKEGTIVAAVIASDTRTDKHSILTITTGVKSTPNDELARSKGKILHDCHAEILALRGFNRLLLEHIKRSMEGIESNLIHNTPNGFEWNNELELTLFISKLPCGELSMSLLEEMKCEDENSLTFEEDDNQQYITPEIKTILRGRCNFNKRNYVRTKPGRIDSKATYSKSCSDKLYIRHKTSVLNSLTSYMMPTPLYISNYVIPNINSHQIEEMNLYFNRPMDLHSSARRLYIHTSHYKFGDDLSPETPPSSMSALKILFNDNDIQEEQILNGVKNGYYTKASKPLRKNCESKVSRYSLWSLFITMHREFKDLTYLEFKRRYCAERAELIRSIKSSLSSDGWLSTAEDDCQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRM4</accession>
    <name>Q6FRM4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0H07425g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRM4"/>
    <dbReference type="FunCoup" id="Q6FRM4">
        <property type="interactions" value="1333"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRM4"/>
    <dbReference type="KEGG" id="cgr:2888766"/>
    <dbReference type="CGD" id="CAL0130603">
        <property type="gene designation" value="CAGL0H07425g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H07425g"/>
    <dbReference type="eggNOG" id="KOG0551">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040446_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FRM4"/>
    <dbReference type="OMA" id="WRAAQCA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21381">
        <property type="entry name" value="CTWD_TTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="255"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0130603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="380" mass="43834" checksum="0A40489294DB7C0C" modified="2004-07-19" version="1">MSSTKKEYKKPQKYVPGINDPILPPQLAEFQDKSTDEVLTELNRMPFFMTKLDNSDGDGGENVELEALKALAYEGEPHEIAENFKKQGNDLYKVKRFRDARELYSKGIDVKCQVNTINESLYANRAACELEIKNYRRCINDCKQALQLNPKNIKCYYRIAKAFTALERLDEALESIEFGEKIDNTNKSLKTLKLHIETKQLEIEARRLKLENEKKERENYQFILNSAIELRNITNIKTSKPAELLREASIKLENPLELESQLIIPAVVLFPLSDEFDFIAEVGELSTVQDVIDILMERPPEWFERPEHKGYSSKSLLAFMETEGGGLVKAGKKLTFHDILRKEKPNVPLFDSALKVFLVPKDQSDDWLSKWDKEKALARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRW6</accession>
    <name>Q6FRW6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0H05335g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRW6"/>
    <dbReference type="FunCoup" id="Q6FRW6">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRW6"/>
    <dbReference type="KEGG" id="cgr:2888532"/>
    <dbReference type="CGD" id="CAL0131650">
        <property type="gene designation" value="CAGL0H05335g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05335g"/>
    <dbReference type="eggNOG" id="ENOG502QSIQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023181_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRW6"/>
    <dbReference type="OMA" id="ICQIRAI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="72"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0131650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="483" mass="55084" checksum="3B3C6D60632278D8" modified="2004-07-19" version="1">MLLVPILQTNKDLFKTIIDQLFYGFRRSNSFKAGVGLIGLLVSYIVYPSVKNILFSKNINGSLASRPDKYTTGLVNKGNYCYANSVIQALSSIDYFSDYINKFVIGIDENEISSAGLEKTDTEALLLHRALADLLRKLQMVIFEPTNADIKHLVSVLEWKVSGRLSRAQNDAHEFLQVLLEQLHVELSNSHKTSSCKFPFAGTIIESYKCLQCQHETAPKKSTFNIFEAPLPQKYEIDLNDVLMRNSNEIIDDYKCMVCLIRSVITLERAHGFSGTAESIKGKLLALEKKLPDITINEEFDIELQNYLDTYCKYGFKNNVARRSILKQCKFVNAPDIFVIHLSRSTYNGMTFTRNGCKVHFGETLDAFETVACSTSSNEFTKRVRYRLKSIVIHTGSHYSGHYQVLRRKPIIMKSKVSGDIVNTGTTIGEKKPTVMDSNFRRMKSTTIYPFWLISDTNVKEKRISDIVNEQKSVYMLFYERIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRX1</accession>
    <name>Q6FRX1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H05225g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRX1"/>
    <dbReference type="FunCoup" id="Q6FRX1">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888652"/>
    <dbReference type="CGD" id="CAL0130555">
        <property type="gene designation" value="CAGL0H05225g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05225g"/>
    <dbReference type="eggNOG" id="ENOG502S263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075862_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FRX1"/>
    <dbReference type="OMA" id="YHDWEDL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF2">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0130555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23588" checksum="5D216BCBBCD8ED48" modified="2004-07-19" version="1">MALQPMNWASIKQNIESGELQNLKRSPIETEKYHEHKRILAEKNIEIGDYILNKLGWTLNELASVNDISEEEKLSLSFSRKDLYKLSVNDFPYNFEPQVSHLLIWSKINLPLYNKNESSTDMNPEMKTKIETFIHNNLSKYLDLDMKDDYCWFINYRNLQSIKGIAHVHLLIRCVDENGPQGNRCQRIKNEILNEGFEPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS43</accession>
    <name>Q6FS43_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0H03619g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446951.1">
        <property type="nucleotide sequence ID" value="XM_446951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS43"/>
    <dbReference type="FunCoup" id="Q6FS43">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS43"/>
    <dbReference type="KEGG" id="cgr:2888621"/>
    <dbReference type="CGD" id="CAL0129842">
        <property type="gene designation" value="CAGL0H03619g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03619g"/>
    <dbReference type="eggNOG" id="ENOG502QUXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019029_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FS43"/>
    <dbReference type="OMA" id="RITRIWY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0129842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG59884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="480" mass="53806" checksum="91B94BA092C64F7B" modified="2004-07-19" version="1">MKVVVFSGGTATNSLTPCFNELSINQGEDLTYVLPISDNGGSTSEILRVLGGPAVGDIRSRIVRLIEDPALTKLFGYRLPQDTQAAKDEWNKIVEGTHIIWKNIPVESRDMARPFLINVQSELLKKSKNSNPFHFGKASIGNFFLTGVRLFLGSVDASIELMMRIGRANTHLNVIPCINTNHTHHISALLTNGEVITGQSQISHPSKPQEPQDKVEAKKNNENISEETLSSNRGSSVSITKDKFVQLLENNDESSSLNQDTTDSVEESGNTWTDINDTEEEEFANPIYILPALKESQINFDKMDDCTLPAPIKRILYINPYGEEIRPVGNPRAVAEIKQADMLVYSIGSLMTSLLPIIILGNIADVISETKSMKKVLLINNKYDRETFFLSGISYIKMVVDSMRRAIEVYRTSKDPSKTERKSIHINWNDLITDVVYLSEGEIKFNEDQLNMKGIRCHEVKGKQMENEILTNILQKIHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS88</accession>
    <name>Q6FS88_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H02541g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS88"/>
    <dbReference type="FunCoup" id="Q6FS88">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888504"/>
    <dbReference type="CGD" id="CAL0131820">
        <property type="gene designation" value="CAGL0H02541g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02541g"/>
    <dbReference type="eggNOG" id="ENOG502S76G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159429_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FS88"/>
    <dbReference type="OMA" id="GRFGHES"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0131820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="107" mass="12785" checksum="6E5486F23121FA9C" modified="2004-07-19" version="1">MMYKVGVRSINSVRQLSRFRRWHELDLAEQHKFIHKFAENYRKRYPGSKTNLSFRGLMKDIDTYKDSPSVFGIFYNSICDNIDHGRDNGRFAHDSFRKLVLHRNDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS92</accession>
    <name>Q6FS92_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-SCF-type F-box protein ROY1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0H02453g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS92"/>
    <dbReference type="FunCoup" id="Q6FS92">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS92"/>
    <dbReference type="KEGG" id="cgr:2888572"/>
    <dbReference type="CGD" id="CAL0129500">
        <property type="gene designation" value="CAGL0H02453g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02453g"/>
    <dbReference type="eggNOG" id="ENOG502R4NW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446963_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FS92"/>
    <dbReference type="OMA" id="LWNGCEC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005095">
        <property type="term" value="F:GTPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0129500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="64545" checksum="0529A566EA3E5EB6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS94</accession>
    <name>Q6FS94_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 1A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0H02409g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 9">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS94"/>
    <dbReference type="FunCoup" id="Q6FS94">
        <property type="interactions" value="815"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FS94"/>
    <dbReference type="KEGG" id="cgr:2888488"/>
    <dbReference type="CGD" id="CAL0131818">
        <property type="gene designation" value="CAGL0H02409g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H02409g"/>
    <dbReference type="eggNOG" id="KOG3403">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109098_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FS94"/>
    <dbReference type="OMA" id="RRVMMHA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001677">
        <property type="term" value="P:formation of translation initiation ternary complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="11">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0131818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="153" mass="17441" checksum="9D6CBAB23EE6B452" modified="2004-07-19" version="1">MGKKNTKGGKKGRRGKNDSAGPKRELIYKEEGQEYAQITKMLGNGRVEASCFDGIKRMAHIRGKLRKKVWMGQGDIILVSLRDFQDDQCDVVHKYNLDEARTLKSQGELPENAKINETDNFGFESDEDANFEFGNADEDDEEEEDEEFDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSE4</accession>
    <name>Q6FSE4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">eIF-2-alpha kinase GCN2</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">GCN2</name>
        <name evidence="26 27" type="ordered locus">CAGL0H01199g</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FSE4">
        <property type="interactions" value="941"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FSE4"/>
    <dbReference type="KEGG" id="cgr:2888699"/>
    <dbReference type="CGD" id="CAL0131690">
        <property type="gene designation" value="GCN2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01199g"/>
    <dbReference type="eggNOG" id="KOG1035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001222_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FSE4"/>
    <dbReference type="OMA" id="FEDIAWD"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071232">
        <property type="term" value="P:cellular response to histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990625">
        <property type="term" value="P:negative regulation of cytoplasmic translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071264">
        <property type="term" value="P:positive regulation of translational initiation in response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14012">
        <property type="entry name" value="PK_eIF2AK_GCN2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000856">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001061">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000379">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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</entry>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
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            <dbReference type="DOI" id="10.1038/nature02579"/>
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            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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</entry>
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        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L44</fullName>
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        <name evidence="5 6" type="ordered locus">CAGL0G05940g</name>
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        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
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        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59547.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT24"/>
    <dbReference type="FunCoup" id="Q6FT24">
        <property type="interactions" value="747"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT24"/>
    <dbReference type="KEGG" id="cgr:2888402"/>
    <dbReference type="CGD" id="CAL0129156">
        <property type="gene designation" value="CAGL0G05940g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G05940g"/>
    <dbReference type="eggNOG" id="KOG3464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FT24"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0129156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG59547.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12139" checksum="680CADCBB1A6B2F0" modified="2008-09-23" version="2">MVNVPKTRKTYCKGKACRKHTQHKVTQYKAGKASLFAQGKRRYDRKQSGFGGQTKPVFHKKAKTTKKVVLRLECVNCKTKAQLTLKRCKHFELGGEKKQKGQALQF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FT85</accession>
    <name>SLD5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">SLD5</name>
        <name type="ordered locus">CAGL0G04587g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380953">
        <property type="protein sequence ID" value="CAG59486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446559.1">
        <property type="nucleotide sequence ID" value="XM_446559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FT85"/>
    <dbReference type="SMR" id="Q6FT85"/>
    <dbReference type="FunCoup" id="Q6FT85">
        <property type="interactions" value="681"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FT85"/>
    <dbReference type="EnsemblFungi" id="CAGL0G04587g-T">
        <property type="protein sequence ID" value="CAGL0G04587g-T-p1"/>
        <property type="gene ID" value="CAGL0G04587g"/>
    </dbReference>
    <dbReference type="GeneID" id="2888425"/>
    <dbReference type="KEGG" id="cgr:2888425"/>
    <dbReference type="CGD" id="CAL0137781">
        <property type="gene designation" value="CAGL0G04587g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_G04587g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0G04587g"/>
    <dbReference type="eggNOG" id="KOG3176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071893_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FT85"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome G"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21692">
        <property type="entry name" value="GINS_B_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000009">
        <property type="entry name" value="DNA replication complex GINS protein SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0159">Chromosome partition</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000255429" description="DNA replication complex GINS protein SLD5">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="309" mass="35585" checksum="92DF3DCDA35462FD" modified="2004-07-19" version="1">MDIDIDDILAELDRDTTAVASSSGQHGFLDANSSMQHVTQTTAFDSSLPHANNLQKDYSPVTPEQDYLQLLKHWRNERCAPELLPLPKLLVSRMLKRIQDQMEHIENISMGFLEHEILEKDGEEAIGQNEYQNNALNNGKLPLLCMEAELERVKFVMRSYLRCRLNKIDKYSLYLRQLGDQGINLISLDELMSEQELKYHAKHSVILLKLLNNSILRHMPPELQAINDTEGSVSMIEEPNWKKFVFIYVNGPANVADDPQLQQSEDGKYYYNITIPEFDEIVELTTGSIYVMRYDIVKDLLRDGKVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FTW3</accession>
    <name>Q6FTW3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">DNA repair protein RAD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0F08327g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FTW3"/>
    <dbReference type="FunCoup" id="Q6FTW3">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FTW3"/>
    <dbReference type="KEGG" id="cgr:2887604"/>
    <dbReference type="CGD" id="CAL0130940">
        <property type="gene designation" value="CAGL0F08327g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F08327g"/>
    <dbReference type="eggNOG" id="KOG2520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003018_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FTW3"/>
    <dbReference type="OMA" id="PNSMDFS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000057">
        <property type="entry name" value="RAD2p Single-stranded DNA endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="13">
        <location>
            <begin position="741"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="638"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0130940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG59255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="992" mass="113325" checksum="8780A55C151AD325" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU63</accession>
    <name>Q6FU63_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0F05973g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU63"/>
    <dbReference type="FunCoup" id="Q6FU63">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU63"/>
    <dbReference type="KEGG" id="cgr:2887743"/>
    <dbReference type="CGD" id="CAL0131020">
        <property type="gene designation" value="CAGL0F05973g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05973g"/>
    <dbReference type="eggNOG" id="KOG3772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036651_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FU63"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="266"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="423"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="492"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="492"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0131020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG59155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="533" mass="61046" checksum="9A6661BF6B74169B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FU94</accession>
    <name>Q6FU94_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin patches distal protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0F05247g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FU94"/>
    <dbReference type="FunCoup" id="Q6FU94">
        <property type="interactions" value="54"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FU94"/>
    <dbReference type="KEGG" id="cgr:2887795"/>
    <dbReference type="CGD" id="CAL0131400">
        <property type="gene designation" value="CAGL0F05247g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F05247g"/>
    <dbReference type="eggNOG" id="ENOG502QT0V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033921_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FU94"/>
    <dbReference type="OMA" id="CTIKYPA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0131400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG59124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="34499" checksum="FBEBBAA20A643C1D" modified="2004-07-19" version="1">MTLLSDNAKQEIAKNIELIDDSCLNCDCQNEEGLDEIQSGEKVFDKLVIDHETELFNSSKIPKVHFIVPTSQMDWQFDACMEKPNSVQYKISTWCSENTERLSAITGCGGVSMNCNVTSMPLNILDIEAMRGTKNNVLVLPFGIWIQDLRSDNVEAILDELVPAILDPKTDIKQLIASKEYLYESHKKAFIFICSHKTRDKRCGITAPILKKIFDRELQNHGLFRDNSDLRGDGVNVSYINHVGGHKFAANVQIYLKDQHTLVWFGRITPKDIPHIVNHLIVPDHGKLPFPEKIRCVKKYDSW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-09" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUG0</accession>
    <name>EFR3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EFR3</name>
        <name type="ordered locus">CAGL0F03773g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_446134.1">
        <property type="nucleotide sequence ID" value="XM_446134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUG0"/>
    <dbReference type="SMR" id="Q6FUG0"/>
    <dbReference type="FunCoup" id="Q6FUG0">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUG0"/>
    <dbReference type="EnsemblFungi" id="CAGL0F03773g-T">
        <property type="protein sequence ID" value="CAGL0F03773g-T-p1"/>
        <property type="gene ID" value="CAGL0F03773g"/>
    </dbReference>
    <dbReference type="GeneID" id="2887797"/>
    <dbReference type="KEGG" id="cgr:2887797"/>
    <dbReference type="CGD" id="CAL0130914">
        <property type="gene designation" value="CAGL0F03773g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03773g"/>
    <dbReference type="eggNOG" id="KOG1877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_371806_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUG0"/>
    <dbReference type="OMA" id="LYYVNSR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000270773" description="Protein EFR3">
        <location>
            <begin position="1"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="749" mass="84960" checksum="0053F78244CF1DD1" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUI6</accession>
    <name>Q6FUI6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GPI transamidase component GPI17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 13" type="ordered locus">CAGL0F03179g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380952">
        <property type="protein sequence ID" value="CAG59032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUI6"/>
    <dbReference type="FunCoup" id="Q6FUI6">
        <property type="interactions" value="815"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUI6"/>
    <dbReference type="KEGG" id="cgr:2887608"/>
    <dbReference type="CGD" id="CAL0129899">
        <property type="gene designation" value="CAGL0F03179g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0F03179g"/>
    <dbReference type="eggNOG" id="KOG2459">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010026_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FUI6"/>
    <dbReference type="OMA" id="AEHKYAV"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome F"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="498"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0129899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG59032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="60607" checksum="728B526CAF120783" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUX3</accession>
    <name>Q6FUX3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0E06468g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUX3"/>
    <dbReference type="FunCoup" id="Q6FUX3">
        <property type="interactions" value="596"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FUX3"/>
    <dbReference type="KEGG" id="cgr:2887297"/>
    <dbReference type="CGD" id="CAL0128978">
        <property type="gene designation" value="CAGL0E06468g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E06468g"/>
    <dbReference type="eggNOG" id="KOG1304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009646_3_1_1"/>
    <dbReference type="InParanoid" id="Q6FUX3"/>
    <dbReference type="OMA" id="DTHRHIY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015188">
        <property type="term" value="F:L-isoleucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015824">
        <property type="term" value="P:proline transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF530">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="620"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="288"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0128978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG58890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="681" mass="75918" checksum="0097A14E667BCE07" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FUZ5</accession>
    <name>Q6FUZ5_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0E05984g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FUZ5"/>
    <dbReference type="KEGG" id="cgr:2887436"/>
    <dbReference type="CGD" id="CAL0128656">
        <property type="gene designation" value="CAGL0E05984g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E05984g"/>
    <dbReference type="HOGENOM" id="CLU_1815541_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FUZ5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0128656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG58868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="142" mass="15867" checksum="FCE4E8FFD3D3F7CD" modified="2004-07-19" version="1">MSNLLNKISDKLHGNDDKEESNSSMSYNTSSNKNLDRDDYESGQSYGFNDSNNYDTNARSHEGYGQGGSNTMPSKHGDTYYNPNERTNDFSETRGMSGTTNLDTDDWGEDVEADVIDSKRYNKGSGAFPSYNSGNMNQNDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVB7</accession>
    <name>Q6FVB7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein PTI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0E03179g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVB7"/>
    <dbReference type="FunCoup" id="Q6FVB7">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVB7"/>
    <dbReference type="KEGG" id="cgr:2887301"/>
    <dbReference type="CGD" id="CAL0128614">
        <property type="gene designation" value="CAGL0E03179g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E03179g"/>
    <dbReference type="eggNOG" id="KOG0108">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040439_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVB7"/>
    <dbReference type="OMA" id="EMGFINY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031126">
        <property type="term" value="P:sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030847">
        <property type="term" value="P:termination of RNA polymerase II transcription, exosome-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF11">
        <property type="entry name" value="PROTEIN PTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cleavage stimulation factor subunit 2 hinge" evidence="5">
        <location>
            <begin position="181"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription termination and cleavage factor C-terminal" evidence="4">
        <location>
            <begin position="385"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0128614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG58746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="46674" checksum="A0F1426170C7C41D" modified="2004-07-19" version="1">MSDPRKRNTRHQLTPDNLSTSILVTNIPSDWNQDVVSSVVAGSGPIIDISSRKDPRTGKVNGLVYDYREPQDCRRAYDLLQRVEKLPFELERIIPSNYKNRTESVKDKPEIQLDRENFPWNAQLSLPFDMISEVPLPKKAPTATATSSNTTKNNDNNIVNSIGSNGVVVFPEILIKSSQNLPKLEKEALESSDPISANLSKIPPAQMIEVISNLKMLANQHNTKRSQLETFLKSNNDILMTMSQAMLEMGFIDYEVVTQVMKDVTKESKSGKSTNSNSNSNSNSNSATPIMPQFNTMATPPMAMGGMVPPVNNMNMGGMVPMQGFMPAAPQFNYSPPPPVPAPMQVPMSGPVSTPTQAPPVPMPAPVQMNEPEINVIKLQQLPENQREMVKQVLKLTDSQIAALPEQQRAMVTNLRKEYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVG1</accession>
    <name>Q6FVG1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0E02145g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CR380951">
        <property type="protein sequence ID" value="CAG58702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445783.1">
        <property type="nucleotide sequence ID" value="XM_445783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVG1"/>
    <dbReference type="STRING" id="284593.Q6FVG1"/>
    <dbReference type="KEGG" id="cgr:2887397"/>
    <dbReference type="CGD" id="CAL0128928">
        <property type="gene designation" value="CAGL0E02145g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0E02145g"/>
    <dbReference type="eggNOG" id="KOG0578">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_874349_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FVG1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome E"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000356">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="8">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0128928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG58702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="318" mass="36009" checksum="75ECAC084DF68659" modified="2004-07-19" version="1">MMKAKPGQPLVVRRQGWVSYKDDGFLSLLWQKRYMILNDCYIDLYKGNKRTDSAIVSIPLTNIVCVSLHKAKPFCLEIVKVNSRPSMSVNGGGVASDSINKNNTKSIYVALKTEQELYGWVDTIFAKCPLLSGVSSPTNFIHSVHVGFEADTGNFIGLPSDWERMLAYNRSNTPVDKPNIIKSSNSIRRKFSLPKRSSSMSRARSVLKPVKQSLSINRKSSLRNDTTNMGKQACKITSHRNGARSPERGSQLWTYQNRNLGGRDSTVLSTRYDRHGHDQNRDDDDYIINTNTAFVNSIQTNSNDENSILHYYEQFLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="146" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVW4</accession>
    <name>Q6FVW4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="16">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0D05060g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="16"/>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVW4"/>
    <dbReference type="FunCoup" id="Q6FVW4">
        <property type="interactions" value="1279"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVW4"/>
    <dbReference type="KEGG" id="cgr:2886980"/>
    <dbReference type="CGD" id="CAL0128199">
        <property type="gene designation" value="CAGL0D05060g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D05060g"/>
    <dbReference type="eggNOG" id="KOG0376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_5_2_1"/>
    <dbReference type="InParanoid" id="Q6FVW4"/>
    <dbReference type="OMA" id="IHKKYAF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000036">
        <property type="entry name" value="Serine/threonine protein phosphatase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 15" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="17">
        <location>
            <begin position="304"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="CGD" id="CAL0128199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG58541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="510" mass="57342" checksum="8B725C92865001EF" modified="2004-07-19" version="1">MGATDADKALEYKNEGNACVKVQDYAKAIEKYDKAIELDDTQSVYFSNRALCHLKLDNFQCASQDCDKALALDPKNVKAYHRRGLACVGLLEFKKARADLTVVLKAKPSDAAAKRALDICEKVIREERFRKAIGGGDSDSKPKLCSTLNLSSFDANSDLAKYDGPSLEFEQLKNEKNEYAGVKITNMSQDFITKLVNDVFLQGKNIPKKYAAAIISHADRLFRDEANLLELSNKESPDHKISVCGDTHGQFYDVLNIFKKYGKVSENHTYLFNGDFVDRGSWSCEVALLFYSLKILFPKNFFLNRGNHETDNMNKIYGFEDECKYKYSQRIFDMFSQSFESLPLATLINKDYLVMHGGLPSDKTSTLEDINKLDRFSQPPREGLYMELLWSDPQQADGLGPSQRGLGFAFGPDITADYLKRNNLKKVFRSHEVRMKGVLFEHNNKLATVFSAPNYCDSQGNMGGIIHIVPGKGKLIQNGNDDEDLLVETFEAVKHPDIKPMAYSNGGLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FVX4</accession>
    <name>Q6FVX4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0D04796g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FVX4"/>
    <dbReference type="FunCoup" id="Q6FVX4">
        <property type="interactions" value="817"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FVX4"/>
    <dbReference type="KEGG" id="cgr:2887093"/>
    <dbReference type="CGD" id="CAL0128433">
        <property type="gene designation" value="CAGL0D04796g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D04796g"/>
    <dbReference type="eggNOG" id="KOG3234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_7_1_1"/>
    <dbReference type="InParanoid" id="Q6FVX4"/>
    <dbReference type="OMA" id="EQHPSMR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000065">
        <property type="entry name" value="N-terminal acetyltransferase complex ARD1 subunit homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0128433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG58531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="192" mass="22256" checksum="11FA36746DA386C4" modified="2004-07-19" version="1">MTSIDPFEPSDLFQLNNVNLDTLTENFPLEFYLEYLILWPELFFKSNETASNNALYSGYMMAKTEGKGPEWHSHITAVTVAPEFRRISLASRLCNTLEAITDADPHEVNFIDLFVKCNNDLAIKLYEKLGYSVFRRVVGYYNSQKDGYPSSLKKVNDDKDAFDMRKSMPRDKGKSTRKDGRKHKCYPHDVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW09</accession>
    <name>Q6FW09_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aspartate/glutamate/uridylate kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PRO1</name>
        <name evidence="12 13" type="ordered locus">CAGL0D03894g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445585.1">
        <property type="nucleotide sequence ID" value="XM_445585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW09"/>
    <dbReference type="STRING" id="284593.Q6FW09"/>
    <dbReference type="GeneID" id="2887220"/>
    <dbReference type="KEGG" id="cgr:2887220"/>
    <dbReference type="CGD" id="CAL0128281">
        <property type="gene designation" value="PRO1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03894g"/>
    <dbReference type="eggNOG" id="KOG1154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FW09"/>
    <dbReference type="OMA" id="ELACEGW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000008">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000020">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0128281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG58496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="485" mass="53269" checksum="61869E7DAC2D89B2" modified="2004-07-19" version="1">MSQTIVIKLGTSSLVDEKTREPKLSIMTQVVETVIQLKRQGHKVVIVSSGGIAVGLNAMEMDKKPTDLAEIQAIAAIGQGRLIGRWSMLFQQYGEKIAQILITRNDILGWTQYKNAQNTILQLLEMGVVPIVNENDTLSISEIKFGDNDTLSAITAALVSADHLFLLTDVDCLYTENPRTNPDAKPIVIVPNMDQGVPGVDTSNADAGSSVGTGGMRTKLIAADLATNAGVNTIIMKSDAPSNVKHIVDYLVKYPKKVLYDDNKSSREQSSEPLSLDQLKNHPYGKGGVISPPKSEEDLLSLQDAELKEIKERNVPLHTVFLAKDIDHHLKNREFWILHGLVTKGVLIIDEDAYNTLTNESGDEEHVSEAYVSEVEDDEMSEVDQDHGLLPKDVIEVKGSFHELECVDIKVGKRLPNGKLDPDAPLEYVGRARCNFTSVELNRIKGLPVDRVQDVLGYDVSEYVAHKDNLAFPPSASSVSLQLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FW29</accession>
    <name>Q6FW29_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0D03432g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FW29"/>
    <dbReference type="FunCoup" id="Q6FW29">
        <property type="interactions" value="1455"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FW29"/>
    <dbReference type="KEGG" id="cgr:2887051"/>
    <dbReference type="CGD" id="CAL0128015">
        <property type="gene designation" value="CAGL0D03432g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D03432g"/>
    <dbReference type="eggNOG" id="KOG1567">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035339_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FW29"/>
    <dbReference type="OMA" id="SNPFPWM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="19"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0128015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG58476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="400" mass="45853" checksum="A695DE636B2478DF" modified="2004-07-19" version="1">MTKETPSKVAASALSDLELKDSQSNLKKQLEVLREENREQIEALKAKLSTAAVEHKEYLKSHKVHRHELKELEKDEPLLNDDPDRLTLFPIKYHEIWQAYKRAEASFWTAEEIDLSKDLHDWNNRLNENERFFISRVLAFFAASDGIVNENLVENFSTEAVIPEAKAFYGFQIMIENIHSETYSLLIDTYIKDPKESEFLFNAIHTIPEIGEKAEWALRWIANSEALFAERLVAFAAIEGVFFSGSFASIFWLKKRGLMPGLTFSNELICRDEGLHTDFACLLFAHLNHKPDPEVVERIVTEAVEIEQRYFLDALPVALLGMNAQLMNQYVEFVADRLLVAFGNKKVYNVENPFDFMENISLAGKTNFFEKRVSDYQKAGVMSKAQNTEGGGAFSLDEDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-10-05" modified="2025-04-09" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWB5</accession>
    <name>AIM3A_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Altered inheritance of mitochondria protein 3-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">AIM3-1</name>
        <name type="ordered locus">CAGL0D01474g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane raft</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Localizes within detergent-insoluble glycolipid-enriched membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAG58390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445479.1">
        <property type="nucleotide sequence ID" value="XM_445479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWB5"/>
    <dbReference type="EnsemblFungi" id="CAGL0D01474g-T">
        <property type="protein sequence ID" value="CAGL0D01474g-T-p1"/>
        <property type="gene ID" value="CAGL0D01474g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2887115"/>
    <dbReference type="CGD" id="CAL0128437">
        <property type="gene designation" value="CAGL0D01474g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0D01474g"/>
    <dbReference type="eggNOG" id="ENOG502S02E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415040_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWB5"/>
    <dbReference type="OMA" id="IGPKSQH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031370">
        <property type="entry name" value="Aim3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17096">
        <property type="entry name" value="AIM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000399598" description="Altered inheritance of mitochondria protein 3-1">
        <location>
            <begin position="1"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="487"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="263"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="661" mass="72433" checksum="6D62A95CC033F4F7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWN0</accession>
    <name>Q6FWN0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Trehalase</fullName>
            <ecNumber evidence="5">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NTH2</name>
        <name evidence="7 8" type="ordered locus">CAGL0C04323g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="5"/>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445364.1">
        <property type="nucleotide sequence ID" value="XM_445364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWN0"/>
    <dbReference type="STRING" id="284593.Q6FWN0"/>
    <dbReference type="CAZy" id="GH37">
        <property type="family name" value="Glycoside Hydrolase Family 37"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886818"/>
    <dbReference type="CGD" id="CAL0127228">
        <property type="gene designation" value="NTH2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C04323g"/>
    <dbReference type="eggNOG" id="KOG0602">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006451_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FWN0"/>
    <dbReference type="OMA" id="ESATAYW"/>
    <dbReference type="PHI-base" id="PHI:11139"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000026">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011120">
        <property type="entry name" value="Trehalase_Ca-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF6">
        <property type="entry name" value="CYTOSOLIC NEUTRAL TREHALASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07492">
        <property type="entry name" value="Trehalase_Ca-bi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Neutral trehalase Ca2+ binding" evidence="6">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0127228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG58270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="750" mass="86457" checksum="7784316F47CDEF0B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FWT6</accession>
    <name>Q6FWT6_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0C03003g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380949">
        <property type="protein sequence ID" value="CAG58214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_445308.1">
        <property type="nucleotide sequence ID" value="XM_445308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FWT6"/>
    <dbReference type="FunCoup" id="Q6FWT6">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FWT6"/>
    <dbReference type="KEGG" id="cgr:2886726"/>
    <dbReference type="CGD" id="CAL0127268">
        <property type="gene designation" value="CAGL0C03003g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0C03003g"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078327_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FWT6"/>
    <dbReference type="OMA" id="TPLHHCE"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome C"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0127268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG58214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="206" mass="23422" checksum="BBCC6F33CEF90FBF" modified="2004-07-19" version="1">MNIWIAASDGRGDIVEKFLADGLSANSKDPNGYTPVHAAAAYGHLDLLRKLCQEHGGDINVRDSDGDTPLHHCEDVRVAQLIVEELGGDYTLTNDEGKTALQVFEEDAEFPELIQYMRVKSGLNKDEDSLGIDQDQLAQFKDSVRYTLEQEPDELTDPESIERRKRLEKIVMGENPEQELEAYIREMVRSQMMNQDQDQEPSKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXB3</accession>
    <name>Q6FXB3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bud site selection protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BUD5</name>
        <name evidence="9 10" type="ordered locus">CAGL0B01287g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="148"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="680"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
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            <end position="1246"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
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    </feature>
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            <begin position="116"/>
            <end position="125"/>
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        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="1247" mass="142771" checksum="CE9FCBC2006CB7BC" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXL9</accession>
    <name>Q6FXL9_CANGA</name>
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        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PGS1</name>
        <name evidence="20 21" type="ordered locus">CAGL0B04741g</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Essential for the viability of mitochondrial petite mutant. Catalyzes the committed step to the synthesis of the acidic phospholipids.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="5 18"/>
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        <property type="protein sequence ID" value="CAG58076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="cgr:2886693"/>
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        <property type="gene designation" value="PGS1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAGL0B04741g"/>
    <dbReference type="eggNOG" id="KOG3964">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_030471_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FXL9"/>
    <dbReference type="OMA" id="HKCLAQC"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome B"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0000316"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="CDD" id="cd09135">
        <property type="entry name" value="PLDc_PGS1_euk_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000046">
        <property type="entry name" value="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000850">
        <property type="entry name" value="Phospholipase_D_PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="19">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="CGD" id="CAL0127096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="CAG58076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="506" mass="58286" checksum="609B0C3B257DEB9D" modified="2004-07-19" version="1">MLPTSIAPNHCRVYSHQLRKFMTQPSNYYESVQSSLSYLKTKFLFKRGEIEVIESPSEFYDTLKKKITTAKKRVFIASLYLGSSEDELIKCVSDAMKNNKDLKVSFLIDGLRGTRETPAKCSASLLATLVRDYGNRVDTRLYRTPAYVGWKRLLIPKRYNEGIGLQHMKIYGFDDEVLLSGANLSNDYFTNRQDRYYLFKRKEFTDYYYSLHKTISALSYKVEYSNNNQKYKMFWPSDNLANEPIHGRRQFLKKSSLVISEFLNRPRKPNIPIDDLGKYPTTVYPVSQFTPLFNRGYDESTERPAVLKLINSMCSPLNEWFFTAGYFNMLPDIKKALFSCRAKAGTVITASPYANGFFESKGMSGSIPDAYLYLSKKFLKDVRKSGKSDTITLREWQRGVVNKPNGWSYHAKGIWITDSTDDSDKGYPVGTIIGSSNYTRRAYSLDLESNAIIVTKDEQLRENMQHELDNILKYTKPVNLEDFNNEAHRQVNTKVKVATAMLGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXW7</accession>
    <name>Q6FXW7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="16">2.7.7.1</ecNumber>
            <ecNumber evidence="16">2.7.7.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 20" type="ordered locus">CAGL0A01023g</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate to form deamido-NAD(+) (NaAD). Key enzyme in both de novo and salvage pathways for NAD(+) biosynthesis. Predominantly acts in the salvage pathways via NMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>beta-nicotinamide D-ribonucleotide + ATP + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the eukaryotic NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="16"/>
    <dbReference type="EC" id="2.7.7.18" evidence="16"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXW7"/>
    <dbReference type="FunCoup" id="Q6FXW7">
        <property type="interactions" value="552"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FXW7"/>
    <dbReference type="KEGG" id="cgr:2886457"/>
    <dbReference type="CGD" id="CAL0126619">
        <property type="gene designation" value="CAGL0A01023g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A01023g"/>
    <dbReference type="eggNOG" id="KOG3199">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033366_5_0_1"/>
    <dbReference type="InParanoid" id="Q6FXW7"/>
    <dbReference type="OMA" id="VPHGIQR"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09286">
        <property type="entry name" value="NMNAT_Eukarya"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000074">
        <property type="entry name" value="Nicotinamide-nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051182">
        <property type="entry name" value="Euk_NMN_adenylyltrnsfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045094">
        <property type="entry name" value="NMNAT_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00482">
        <property type="entry name" value="nicotinate (nicotinamide) nucleotide adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039">
        <property type="entry name" value="NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12039:SF0">
        <property type="entry name" value="NICOTINAMIDE-NUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 16" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="18">
        <location>
            <begin position="166"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="51"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="CGD" id="CAL0126619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="CAG57706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="411" mass="46729" checksum="1D59CC3EB3CD106C" modified="2004-07-19" version="1">MDPTRDPDFKPRDPDAKLLPPPDPTSKIPKSGPITPYVLADYNASIDAPLQMKKNTTHLPHSQGNHQRIPLNKSEFQPLSTTGSSEEDFELDDENMDSDSGSKRESLGQLSGHGIGIGVHKNQIADLEEVPHGIVRQARFLEDYEFPTHRLANRLQDPNKMPLVIVACGSFSPITYLHLRMFEMALDAISEMTRFEVVGGYYSPVSDNYKKQGLAPSYHRVRMCELACERTSSWLMVDAWESLQPSYTRTAKVLDHFNHEINVKRGGITVHEKKRNADNSGYHMEEHKRGVKIMLLAGGDLIESMGEPGVWADEDLHHILGNYGCLIVERTGSDVRSFLLSHDIMYEHRRNVLVIKQLIYNDISSTKVRLFIRRNMSVQYLLPNSVIRYIQEHKLYINQSEPVKQVLSGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FXX9</accession>
    <name>Q6FXX9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 12" type="ordered locus">CAGL0A00737g</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_444803.1">
        <property type="nucleotide sequence ID" value="XM_444803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FXX9"/>
    <dbReference type="FunCoup" id="Q6FXX9">
        <property type="interactions" value="1487"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886423"/>
    <dbReference type="CGD" id="CAL0126917">
        <property type="gene designation" value="CAGL0A00737g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A00737g"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_30_1_1"/>
    <dbReference type="InParanoid" id="Q6FXX9"/>
    <dbReference type="OMA" id="INNMACP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000044">
        <property type="entry name" value="Hexose transporter Hxt3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF75">
        <property type="entry name" value="GALACTOSE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="50"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="CGD" id="CAL0126917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="CAG57694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="549" mass="61556" checksum="1AD45A422BBA5CDE" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="145" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FY57</accession>
    <name>Q6FY57_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0A02750g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FY57"/>
    <dbReference type="FunCoup" id="Q6FY57">
        <property type="interactions" value="1068"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FY57"/>
    <dbReference type="KEGG" id="cgr:2886364"/>
    <dbReference type="CGD" id="CAL0126743">
        <property type="gene designation" value="CAGL0A02750g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A02750g"/>
    <dbReference type="eggNOG" id="KOG0652">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_4_1"/>
    <dbReference type="InParanoid" id="Q6FY57"/>
    <dbReference type="OMA" id="NKISHEH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045899">
        <property type="term" value="P:positive regulation of RNA polymerase II transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="209"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0126743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG57778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="429" mass="47636" checksum="925945D26E0E0FED" modified="2004-07-19" version="1">MSTLEELDVEDGLDQEILGLSAQELQTRSKLLDNEIRIFRSELQRLSHENNVMLEKIKDNKEKIKNNRKLPYLVANIVEVMDMDEIEDKENSESATQGGNVNLDNTANGKAAVIKTSSRQTVFLPMVGLVDPDKLKPNDLVGVNKDSYLILDTLPSEFDSRVKAMEVDEKPTETYSDVGGLDKQIEELVEAIVLPMKRADKFKELGIRAPKGALMYGPPGTGKTLLARACAAQTNATFLKLAAPQLVQMFIGEGAKLVRDAFALAKEKAPAIIFIDELDAIGTKRFDSEKSGDREVQRTMLELLNQLDGFSSDDRVKVLAATNRVDVLDPALLRSGRLDRKIEFPLPTEDSRAQILQIHSRKMTTDDDINWQELARSTDEFNGAQLKAVTVEAGMLALRNGQSSVKHEDFVEAIGEVQARKSKSVSFYA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-31" modified="2025-06-18" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FYA7</accession>
    <name>EF2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Elongation factor 2</fullName>
            <shortName>EF-2</shortName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">EFT1</name>
        <name type="ordered locus">CAGL0A03234g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CR380947">
        <property type="protein sequence ID" value="CAG57801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FYA7"/>
    <dbReference type="SMR" id="Q6FYA7"/>
    <dbReference type="FunCoup" id="Q6FYA7">
        <property type="interactions" value="1361"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FYA7"/>
    <dbReference type="EnsemblFungi" id="CAGL0A03234g-T">
        <property type="protein sequence ID" value="CAGL0A03234g-T-p1"/>
        <property type="gene ID" value="CAGL0A03234g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2886326"/>
    <dbReference type="CGD" id="CAL0126687">
        <property type="gene designation" value="EFT2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_A03234g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0A03234g"/>
    <dbReference type="eggNOG" id="KOG0469">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_2_1"/>
    <dbReference type="InParanoid" id="Q6FYA7"/>
    <dbReference type="OMA" id="ASWNTEN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome A"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000091016" description="Elongation factor 2">
        <location>
            <begin position="1"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G" evidence="2">
        <location>
            <begin position="17"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="158"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Diphthamide" evidence="1">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P32324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01059"/>
        </source>
    </evidence>
    <sequence length="842" mass="93329" checksum="B7A4D4771E9CE6B8" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>B4UMZ2</accession>
    <name>B4UMZ2_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">CAGL0D06154g</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380950">
        <property type="protein sequence ID" value="CAR58016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UMZ2"/>
    <dbReference type="KEGG" id="cgr:9487982"/>
    <dbReference type="eggNOG" id="ENOG502S3YH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2442109_0_0_1"/>
    <dbReference type="InParanoid" id="B4UMZ2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome D"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="CAR58016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="91" mass="10306" checksum="7F53AFAE2A6BFCDB" modified="2008-09-23" version="1">MDQIHANPAVMEKLEKVSKIMIEKNLINSDNHDANGQRSFKPMQMIKILMDKDLRLAMNEFKSSLDKAGIQLGPDQLAPLMTVLGIEKEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN06</accession>
    <name>B4UN06_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">CAGL0H01611g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAR57986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN06"/>
    <dbReference type="HOGENOM" id="CLU_3032164_0_0_1"/>
    <dbReference type="InParanoid" id="B4UN06"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAR57986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="55" mass="6054" checksum="5A563FEC47F87FA9" modified="2008-09-23" version="1">MNNTRLMSMSFEQNPRLRPTATGGRNTATNTRNQSLACICTVLLCYIGSQSFAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-09-23" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>B4UN56</accession>
    <name>B4UN56_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M00874g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAR58072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B4UN56"/>
    <dbReference type="FunCoup" id="B4UN56">
        <property type="interactions" value="635"/>
    </dbReference>
    <dbReference type="STRING" id="284593.B4UN56"/>
    <dbReference type="KEGG" id="cgr:9488055"/>
    <dbReference type="CGD" id="CAL0137089">
        <property type="gene designation" value="CAGL0M00874g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00874g"/>
    <dbReference type="eggNOG" id="KOG3460">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_5_1_1"/>
    <dbReference type="InParanoid" id="B4UN56"/>
    <dbReference type="OMA" id="FDSHCNI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140445">
        <property type="term" value="C:chromosome, telomeric repeat region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008266">
        <property type="term" value="F:poly(U) RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="1">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAR58072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="85" mass="9460" checksum="1A4474F44921594B" modified="2008-09-23" version="1">MSLSTPLDLLKLNLDERVYVKLRGARAMEGVLQAFDSHCNIVLSDAVETIYELVDGELKSQERASEMIFVRGDSVTLITAVSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-31" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>F2Z684</accession>
    <name>F2Z684_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">IPC1</name>
        <name evidence="8 9" type="ordered locus">CAGL0K02805g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448347.1">
        <property type="nucleotide sequence ID" value="XM_448347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="F2Z684"/>
    <dbReference type="STRING" id="284593.F2Z684"/>
    <dbReference type="GeneID" id="2890128"/>
    <dbReference type="KEGG" id="cgr:2890128"/>
    <dbReference type="CGD" id="CAL0134961">
        <property type="gene designation" value="IPC1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02805g"/>
    <dbReference type="eggNOG" id="ENOG502QPQM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030747_2_0_1"/>
    <dbReference type="InParanoid" id="F2Z684"/>
    <dbReference type="OMA" id="WSIYDAQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045140">
        <property type="term" value="F:inositol phosphoceramide synthase activity"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006673">
        <property type="term" value="P:inositol phosphoceramide metabolic process"/>
        <property type="evidence" value="ECO:0000247"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="178"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0134961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG61308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="416" mass="47433" checksum="1D358E841B975A72" modified="2011-05-31" version="1">MRLGRWFAILSSKLCSDTDVTKLERSLDVRVTLRRLRSYRPTIGDTVHYSFLSMILLYSYFANPLPFIVKTLIAMILMTLFVVPMTSQFFFNALPILTWLILYFTSSHIPNSHRPSISVEVLPAIETILYGDNLSEILAAWQNTILDILAWIPYGLFHFGAPFVVAIVLFIFGPPTVLQGYAFAFGYVNLFGVLFQNIFPAAAPWYKIHYGLQVANYSIKGMPGGLSRIDDLLGVNLYSSGFKNSAVVFGAFPSLHSACATMEALFFSYCFPSLTPLFIFYVWWLWWSTMYLTHHYFVDLTAGSVLAYFIFQYTKYTHLPIVDPNLLFRWSYDSIEFYDVKNNDPLSITNNDIESIPLNTIELDTEEVFNIEREKSRTPELSHAVSSSSLANGRSQTYPNTGNTFKSKTRLSKLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-05-31" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>F2Z6H6</accession>
    <name>F2Z6H6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0H03069g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="F2Z6H6">
        <property type="interactions" value="835"/>
    </dbReference>
    <dbReference type="STRING" id="284593.F2Z6H6"/>
    <dbReference type="MEROPS" id="S59.002"/>
    <dbReference type="KEGG" id="cgr:2888637"/>
    <dbReference type="CGD" id="CAL0129636">
        <property type="gene designation" value="CAGL0H03069g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03069g"/>
    <dbReference type="eggNOG" id="KOG0845">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005908_0_0_1"/>
    <dbReference type="InParanoid" id="F2Z6H6"/>
    <dbReference type="OMA" id="PMGKGLN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051664">
        <property type="term" value="P:nuclear pore localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046822">
        <property type="term" value="P:regulation of nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="15">
        <location>
            <begin position="456"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="256"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="395"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="699"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="72"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="272"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0129636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG59859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1283" mass="142299" checksum="7822CEE7836C84BE" modified="2011-05-31" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-26" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIK5</accession>
    <name>DYN3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Cytoplasmic dynein intermediate light chain DYN3</fullName>
            <shortName>Dynein protein 3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">DYN3</name>
        <name type="ordered locus">CAGL0M13695g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytoplasmic dynein which acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The cytoplasmic dynein is composed of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein light intermediate chain DYN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449939.1">
        <property type="nucleotide sequence ID" value="XM_449939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FIK5"/>
    <dbReference type="SMR" id="Q6FIK5"/>
    <dbReference type="FunCoup" id="Q6FIK5">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FIK5"/>
    <dbReference type="EnsemblFungi" id="CAGL0M13695g-T">
        <property type="protein sequence ID" value="CAGL0M13695g-T-p1"/>
        <property type="gene ID" value="CAGL0M13695g"/>
    </dbReference>
    <dbReference type="GeneID" id="2891230"/>
    <dbReference type="KEGG" id="cgr:2891230"/>
    <dbReference type="CGD" id="CAL0137025">
        <property type="gene designation" value="CAGL0M13695g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M13695g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M13695g"/>
    <dbReference type="eggNOG" id="ENOG502S4QG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064762_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FIK5"/>
    <dbReference type="OMA" id="QIRWIFL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0206">Cytoskeleton</keyword>
    <keyword id="KW-0243">Dynein</keyword>
    <keyword id="KW-0493">Microtubule</keyword>
    <keyword id="KW-0505">Motor protein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000292444" description="Cytoplasmic dynein intermediate light chain DYN3">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="315" mass="37152" checksum="328BF479FB3E677F" modified="2004-07-19" version="1">MLRRALEEKYALKIGEIRTTTAVICSISTDTILDFEKQCLKPHCTFSKPIINLGYTYYDIPSEYKEELNESIAVNHRIDAYALITTFDETPIESIEPLISNDKSEIKWTFLLDWTELHQGTWLRFLSKQFESLESKGYDLKNENISVWCMNSDYMFELQKNDILWESFHFEYLQQSLRSVLFYRNGSLIYVDKKRNQLPLFEIFVKLCLHNRNDKYKSLNQFTEMSETSQVFIPFNSDSEDLIKTIDEEFQPEEVLKPDFMPTFEKVIPYSKPKDEPHLPPIGELPHFDMNKELEEAAIILKQASKKEAYAKQNI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-13" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIR8</accession>
    <name>GEM1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Mitochondrial Rho GTPase 1</fullName>
            <ecNumber>3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>GTPase EF-hand protein of mitochondria 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">GEM1</name>
        <name type="ordered locus">CAGL0M12276g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_449876.1"/>
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        <property type="gene ID" value="CAGL0M12276g"/>
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    <dbReference type="GeneID" id="2891426"/>
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        <property type="gene designation" value="GEM1"/>
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    <dbReference type="VEuPathDB" id="FungiDB:B1J91_M12276g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M12276g"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_014255_3_0_1"/>
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        <property type="component" value="Chromosome M"/>
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        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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        <property type="entry name" value="Mitochondrial Rho GTPase"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    <keyword id="KW-0106">Calcium</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
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            <begin position="1"/>
            <end position="649"/>
        </location>
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            <begin position="1"/>
            <end position="623"/>
        </location>
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    <feature type="transmembrane region" description="Helical; Anchor for type IV membrane protein" evidence="2">
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            <begin position="624"/>
            <end position="644"/>
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    </feature>
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            <begin position="3"/>
            <end position="176"/>
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    </feature>
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        <location>
            <begin position="192"/>
            <end position="227"/>
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    </feature>
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        <location>
            <begin position="320"/>
            <end position="355"/>
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            <begin position="436"/>
            <end position="601"/>
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    <feature type="binding site" evidence="2">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
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            <name>GTP</name>
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            <name>GTP</name>
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            <name>GTP</name>
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        <source>
            <dbReference type="UniProtKB" id="P39722"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00448"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="649" mass="73601" checksum="9B15B2EF03BAFC9F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FIS5</accession>
    <name>Q6FIS5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosome-interacting GTPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0M12122g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in ribosomal function.</text>
    </comment>
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        <property type="term" value="P:cytoplasmic translation"/>
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        <property type="project" value="EnsemblFungi"/>
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    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
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        <property type="entry name" value="DRG"/>
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        <property type="entry name" value="TGS_DRG1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="66"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="292"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0136391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="40806" checksum="FB54B085CE80DF7E" modified="2004-07-19" version="1">MSTTVEKIKAIEDEMARTQKNKATSFHLGQLKAKLAKLRRELLTSASSSSGGGGGVGFDVARTGVASVGFVGFPSVGKSTLLSKLTGTESEAAEYEFTTLVTVPGVIRYKGAKIQMLDLPGIIDGAKDGRGRGKQVIAVARTCNLLFIVLDVNKPLHHKQIIEKELEGVGIRLNKEPPNIVIKKKEKGGISITNTVPLTHLGNDEIRAVMSEYRINSAEIAFRCDATVDDLIDVLEAPTRRYMPAIYVLNKIDALSLEELELLYRIPNAVPISSGKEWNLDELLQVMWDRLNLVRIYTKPKGRIPDFNDPVVLRSDRCSVKDFCNQIHKSLVDEFRNALVYGSSVKHQPQYVGLNHILEDEDVVTILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJB4</accession>
    <name>Q6FJB4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EFG1</name>
        <name evidence="6 7" type="ordered locus">CAGL0M07634g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJB4"/>
    <dbReference type="STRING" id="284593.Q6FJB4"/>
    <dbReference type="KEGG" id="cgr:2891730"/>
    <dbReference type="CGD" id="CAL0137219">
        <property type="gene designation" value="EFG1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M07634g"/>
    <dbReference type="eggNOG" id="ENOG502QW2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1081811_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJB4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044406">
        <property type="term" value="P:adhesion of symbiont to host"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900231">
        <property type="term" value="P:regulation of single-species biofilm formation on inanimate substrate"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="5">
        <location>
            <begin position="121"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0137219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG62656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="257" mass="27827" checksum="642AAF617E722051" modified="2004-07-19" version="1">MSERELPGYTYLPPPRLSYQPSIALVPGVMQVRPPASPASPVGTGAGTPGAAGTTGITGISSTTGTTGTGGTALGTVPTSALTNNNNNNNSSSSGNAYMTSALASWNQYQYPWLQHPLLSRVITTYWEDEHTICHGVNHNGVTVVRRADNDMVNGTKLLNVTGMTRGRRDGILKNEPVRDVVKGGPMTLKGVWIPIDRARAIARQEGIEQWLYPLFIDDLHQAITLLRQQVQPQVQMPAPQLPVQSQQLIPQIHHHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJG6</accession>
    <name>Q6FJG6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0M06457g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJG6"/>
    <dbReference type="FunCoup" id="Q6FJG6">
        <property type="interactions" value="725"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJG6"/>
    <dbReference type="KEGG" id="cgr:2891676"/>
    <dbReference type="CGD" id="CAL0136753">
        <property type="gene designation" value="CAGL0M06457g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M06457g"/>
    <dbReference type="eggNOG" id="KOG2881">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040186_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJG6"/>
    <dbReference type="OMA" id="ILGHAIC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010486">
        <property type="term" value="F:manganese:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017495760" description="GDT1 family protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0136753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="267" mass="28825" checksum="2D8B926AA6BEC80F" modified="2004-07-19" version="1">MTTIIAALALLPYVSATTTTTTNTTNDIPASHFGSFAMAVAMIGLSEIGDKTFLIAALMAMRHARLLVFTAAAISLTIMTVLSGFLGHTFVSLIPESYTTFLAGILFLVFAYKLLIEGLEMSKDAGVEEEMTEVEEEIAISTMNEKMDDIEGGSGKGKYTDAASGPVNQVKQLFSKVFSPIWVSIFLMVFLGELGDRSQISIIAMATDNDYWYVIAGGVMGHCICTGIAVLGGKLLATKISMRTITLSSAVLFLIFGIMYIYHAFHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJL3</accession>
    <name>Q6FJL3_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M05401g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449581.1">
        <property type="nucleotide sequence ID" value="XM_449581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJL3"/>
    <dbReference type="KEGG" id="cgr:2891628"/>
    <dbReference type="CGD" id="CAL0136803">
        <property type="gene designation" value="CAGL0M05401g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M05401g"/>
    <dbReference type="HOGENOM" id="CLU_2757542_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJL3"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0136803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="70" mass="7871" checksum="6524C9EC2241C9E9" modified="2004-07-19" version="1">MSLLKFSANQKLQTALQFTYLGLCLVGPFMMPAKQANTGFLALSKSLLSEDHMNSHSLVKGKRHPRAYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJQ4</accession>
    <name>Q6FJQ4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Na(+)/H(+) antiporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CNH1</name>
        <name evidence="15 16" type="ordered locus">CAGL0M04433g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJQ4"/>
    <dbReference type="FunCoup" id="Q6FJQ4">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJQ4"/>
    <dbReference type="KEGG" id="cgr:2891549"/>
    <dbReference type="CGD" id="CAL0136289">
        <property type="gene designation" value="CNH1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M04433g"/>
    <dbReference type="eggNOG" id="KOG4505">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008635_0_1_1"/>
    <dbReference type="InParanoid" id="Q6FJQ4"/>
    <dbReference type="OMA" id="WPITCFF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046583">
        <property type="term" value="F:monoatomic cation efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097623">
        <property type="term" value="P:potassium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0000315"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013928">
        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
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            <begin position="296"/>
            <end position="315"/>
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    <feature type="transmembrane region" description="Helical" evidence="12">
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            <begin position="327"/>
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            <begin position="361"/>
            <end position="382"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="414"/>
            <end position="440"/>
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    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="26"/>
            <end position="437"/>
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    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="465"/>
            <end position="800"/>
        </location>
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        <location>
            <begin position="803"/>
            <end position="919"/>
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            <begin position="510"/>
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            <begin position="584"/>
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            <begin position="675"/>
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        <location>
            <begin position="818"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="527"/>
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        <source>
            <dbReference type="EMBL" id="CAG62516.1"/>
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="945" mass="105726" checksum="E141C828E99DDD01" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJU5</accession>
    <name>Q6FJU5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18 19" type="ordered locus">CAGL0M03531g</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG62475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene designation" value="CAGL0M03531g"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="HOGENOM" id="CLU_010353_2_0_1"/>
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        <property type="component" value="Chromosome M"/>
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        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
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    <keyword evidence="6" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="20"/>
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        <source>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="CAG62475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="932" mass="103694" checksum="8AEB960FB2319E1D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FJZ1</accession>
    <name>Q6FJZ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome chaperone 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0M02453g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FJZ1"/>
    <dbReference type="FunCoup" id="Q6FJZ1">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FJZ1"/>
    <dbReference type="KEGG" id="cgr:2891461"/>
    <dbReference type="CGD" id="CAL0137149">
        <property type="gene designation" value="CAGL0M02453g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M02453g"/>
    <dbReference type="HOGENOM" id="CLU_2049391_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FJZ1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018854">
        <property type="entry name" value="Psome_chaperone_3/4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10448">
        <property type="entry name" value="POC3_POC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0137149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG62429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13290" checksum="E932FD5D037C193D" modified="2004-07-19" version="1">MSQIVVDGLSVRVDCDVEDGVKSPISLNLCLSGDEELKSSRLECYYYTIMGRKDDVLGIPLRDTSSDWIRDLARLCATMITKKYNKPCYVTISTVGENNFQASTIPLLAAVKEHVATLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK34</accession>
    <name>Q6FK34_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0M01496g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK34"/>
    <dbReference type="FunCoup" id="Q6FK34">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK34"/>
    <dbReference type="KEGG" id="cgr:2891179"/>
    <dbReference type="CGD" id="CAL0136399">
        <property type="gene designation" value="CAGL0M01496g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M01496g"/>
    <dbReference type="eggNOG" id="KOG1991">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004196_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK34"/>
    <dbReference type="OMA" id="MVMSMNK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF28">
        <property type="entry name" value="IMPORTIN BETA SMX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="4">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0136399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="951" mass="109081" checksum="EE79CD0512BA6191" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK58</accession>
    <name>Q6FK58_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein ECM30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0M00924g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q6FK58">
        <property type="interactions" value="59"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK58"/>
    <dbReference type="KEGG" id="cgr:2891155"/>
    <dbReference type="CGD" id="CAL0137083">
        <property type="gene designation" value="CAGL0M00924g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00924g"/>
    <dbReference type="eggNOG" id="KOG2226">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003989_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FK58"/>
    <dbReference type="OMA" id="WENGINT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="854"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="863"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0137083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG62362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1303" mass="147967" checksum="19F96895F8C114D7" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FK76</accession>
    <name>Q6FK76_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="13">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0M00528g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="13"/>
    <dbReference type="EMBL" id="CR380959">
        <property type="protein sequence ID" value="CAG62344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FK76"/>
    <dbReference type="FunCoup" id="Q6FK76">
        <property type="interactions" value="913"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FK76"/>
    <dbReference type="KEGG" id="cgr:2891591"/>
    <dbReference type="CGD" id="CAL0137443">
        <property type="gene designation" value="CAGL0M00528g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0M00528g"/>
    <dbReference type="eggNOG" id="KOG2431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003818_3_0_1"/>
    <dbReference type="InParanoid" id="Q6FK76"/>
    <dbReference type="OMA" id="AAFKHSW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome M"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF55">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273306" description="alpha-1,2-Mannosidase" evidence="14">
        <location>
            <begin position="26"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="337"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0137443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG62344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="547" mass="62921" checksum="4F8CE004720DF2CD" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKF3</accession>
    <name>Q6FKF3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent RNA helicase ECM32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0L12034g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="KEGG" id="cgr:2890955"/>
    <dbReference type="CGD" id="CAL0135336">
        <property type="gene designation" value="CAGL0L12034g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L12034g"/>
    <dbReference type="eggNOG" id="KOG1802">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010015_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKF3"/>
    <dbReference type="OMA" id="HPLGKIC"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF317">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE ECM32-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="652"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="776"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="866"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="159"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0135336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG62265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1125" mass="127138" checksum="63C0428123F3CC8C" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKM0</accession>
    <name>Q6FKM0_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L10516g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="CAG62198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKM0"/>
    <dbReference type="FunCoup" id="Q6FKM0">
        <property type="interactions" value="1101"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKM0"/>
    <dbReference type="KEGG" id="cgr:2891035"/>
    <dbReference type="CGD" id="CAL0135622">
        <property type="gene designation" value="CAGL0L10516g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L10516g"/>
    <dbReference type="eggNOG" id="KOG3031">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049783_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKM0"/>
    <dbReference type="OMA" id="VGLKPMF"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="349" mass="40325" checksum="A714628515429E37" modified="2004-07-19" version="1">MIRTVKPKNARAKRALEKRESKLVENTKQALFVPGQTSNKLLHDVMVDLSALKKPDIKRFNKKNDIHPFEDPEPLEFFSEKNDASLLVLSTSSKKRKNNLTFVRTFGYKIYDMIELLIAENYKLLNDFRKRTFTVGLKPMFSFQGSAFETHPVYKQIKSLFLDFFRGQTTDLQDVAGLQHVISISIQGDFQEGEPLPNVLFRVYKLRTYKSEQGGKTLPRVELDEVGPRLDFKIGRVRTPSPEMEKEAHKRAKQLDVKTKKNVEIDTMGDKLGRIHMGKQDLNKLQTRKMKGLKSKFDQVDDDEEDYLNDSEEDLQGSMSEHEDTFGEDFVTADEIDENQPASKKQRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKR8</accession>
    <name>Q6FKR8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0L09207g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_449176.1">
        <property type="nucleotide sequence ID" value="XM_449176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKR8"/>
    <dbReference type="FunCoup" id="Q6FKR8">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKR8"/>
    <dbReference type="KEGG" id="cgr:2891121"/>
    <dbReference type="CGD" id="CAL0135492">
        <property type="gene designation" value="CAGL0L09207g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L09207g"/>
    <dbReference type="eggNOG" id="KOG0236">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003182_10_1_1"/>
    <dbReference type="InParanoid" id="Q6FKR8"/>
    <dbReference type="OMA" id="TGPMSVT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="543"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0135492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG62146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="725" mass="80582" checksum="ECCEC009322D0D57" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKT6</accession>
    <name>Q6FKT6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0L08800g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG62128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FKT6"/>
    <dbReference type="FunCoup" id="Q6FKT6">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FKT6"/>
    <dbReference type="KEGG" id="cgr:2891089"/>
    <dbReference type="CGD" id="CAL0135072">
        <property type="gene designation" value="CAGL0L08800g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L08800g"/>
    <dbReference type="eggNOG" id="KOG3343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086803_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FKT6"/>
    <dbReference type="OMA" id="NELMLHS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000013">
        <property type="entry name" value="Coatomer subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0135072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG62128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="184" mass="20723" checksum="87AA73C168D12DE6" modified="2004-07-19" version="1">MLSLYSVQAVLILDGQGERVFSKYYVAPHGGVEDNVFDVKKQRKFEKELFAKTHKQDSEILLFDDHLVLYKEYIDVTLCLVASLEENEIVLQQVFSAFKGSLDLILNSGIDKKNIQENYDMVVLAIDEMIDNGVVLETDPSTIAARVSKPPKNDTQLTLDLDKGLLGAWGFAKSKLQERLQQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FKV7</accession>
    <name>Q6FKV7_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0L08294g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
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                <person name="Fabre E."/>
                <person name="Fairhead C."/>
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                <person name="Jauniaux N."/>
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                <person name="Kerrest A."/>
                <person name="Koszul R."/>
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                <person name="Nicaud J.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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        <property type="entry name" value="Cadherin-like_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="He_PIG"/>
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    <proteinExistence type="predicted"/>
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        <location>
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            <end position="19"/>
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    <feature type="chain" id="PRO_5004274639" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="3">
        <location>
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            <end position="833"/>
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            <end position="128"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
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</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL73</accession>
    <name>Q6FL73_CANGA</name>
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        <recommendedName>
            <fullName evidence="15">Potassium transport protein</fullName>
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        <name evidence="12" type="primary">TRK1</name>
        <name evidence="12 13" type="ordered locus">CAGL0L05654g</name>
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    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
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                <person name="Zivanovic I."/>
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                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
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            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
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    </reference>
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        <subcellularLocation>
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        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
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        <property type="entry name" value="2a38euk"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
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    </feature>
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    </feature>
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    </feature>
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    </feature>
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    </feature>
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            <begin position="1150"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="CGD" id="CAL0135736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1352" mass="154950" checksum="CE3C24D3E6A3D741" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FL86</accession>
    <name>Q6FL86_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-processing protein PRP40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0L05368g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FL86"/>
    <dbReference type="FunCoup" id="Q6FL86">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FL86"/>
    <dbReference type="KEGG" id="cgr:2890787"/>
    <dbReference type="CGD" id="CAL0135940">
        <property type="gene designation" value="CAGL0L05368g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L05368g"/>
    <dbReference type="eggNOG" id="KOG0152">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005825_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FL86"/>
    <dbReference type="OMA" id="NEPIYKH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039726">
        <property type="entry name" value="Prp40-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864">
        <property type="entry name" value="PRE-MRNA-PROCESSING PROTEIN PRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11864:SF0">
        <property type="entry name" value="PRP40 PRE-MRNA PROCESSING FACTOR 40 HOMOLOG A (YEAST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51676">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="FF" evidence="3">
        <location>
            <begin position="361"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0135940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="68547" checksum="19460A63B303D72D" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-08-16" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLC3</accession>
    <name>RS28_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein eS28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>40S ribosomal protein S28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">RPS28A</name>
        <name type="ordered locus">CAGL0K06061g</name>
    </gene>
    <gene>
        <name type="primary">RPS28B</name>
        <name type="ordered locus">CAGL0L04510g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448486.1">
        <property type="nucleotide sequence ID" value="XM_448486.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448971.1">
        <property type="nucleotide sequence ID" value="XM_448971.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLC3"/>
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        <property type="gene ID" value="CAGL0K06061g"/>
    </dbReference>
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        <property type="gene ID" value="CAGL0L04510g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890451"/>
    <dbReference type="GeneID" id="2890641"/>
    <dbReference type="KEGG" id="cgr:2890451"/>
    <dbReference type="KEGG" id="cgr:2890641"/>
    <dbReference type="CGD" id="CAL0133871">
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    </dbReference>
    <dbReference type="CGD" id="CAL0135818">
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    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_K06061g"/>
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    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06061g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L04510g"/>
    <dbReference type="eggNOG" id="KOG3502">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178987_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FLC3"/>
    <dbReference type="OMA" id="NTGMHGE"/>
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        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000136837" description="Small ribosomal subunit protein eS28">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="67" mass="7620" checksum="A30D583DC7E8A641" modified="2004-07-19" version="1">MDNKTPVTLARVIKVLGRTGSRGGVTQVRVEFLEDTSRTIVRNVKGPVRENDILVLMESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLE8</accession>
    <name>Q6FLE8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Checkpoint forkhead associated with RING domains-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 22" type="ordered locus">CAGL0L03960g</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the DMA1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLE8"/>
    <dbReference type="FunCoup" id="Q6FLE8">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLE8"/>
    <dbReference type="KEGG" id="cgr:2890760"/>
    <dbReference type="CGD" id="CAL0135892">
        <property type="gene designation" value="CAGL0L03960g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L03960g"/>
    <dbReference type="eggNOG" id="KOG3872">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017542_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FLE8"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032186">
        <property type="term" value="P:cellular bud neck septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097271">
        <property type="term" value="P:protein localization to bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090337">
        <property type="term" value="P:regulation of formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16458">
        <property type="entry name" value="RING-H2_Dmap-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000426">
        <property type="entry name" value="DMA1p Ubiquitin-protein ligase (E3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000030">
        <property type="entry name" value="FHA domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042823">
        <property type="entry name" value="Dma1/Dma2_RING-H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="19">
        <location>
            <begin position="377"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="515"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="59"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="196"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="CGD" id="CAL0135892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="CAG61916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="603" mass="66728" checksum="98A079502971552F" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLK4</accession>
    <name>Q6FLK4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">YEATS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="ordered locus">CAGL0L02739g</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380958">
        <property type="protein sequence ID" value="CAG61860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLK4"/>
    <dbReference type="FunCoup" id="Q6FLK4">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FLK4"/>
    <dbReference type="KEGG" id="cgr:2890865"/>
    <dbReference type="CGD" id="CAL0135610">
        <property type="gene designation" value="CAGL0L02739g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0L02739g"/>
    <dbReference type="eggNOG" id="KOG3149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078004_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLK4"/>
    <dbReference type="OMA" id="DAYIVEY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome L"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016665">
        <property type="entry name" value="Sas5/TAF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016551">
        <property type="entry name" value="SAS5/TFIID_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="3">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="CGD" id="CAL0135610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="CAG61860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="229" mass="26429" checksum="4D71CB8DB25A21EC" modified="2004-07-19" version="1">MAFCTKSMGDNTIAITLRVKTQQSVLLDQQLEEGELPLRQWRVEVSMLDRNKDEVKADILSSVTYHLHPTFVKPRRKMKTPPFSLEEIGWGEFSMTLMCKFRHNGGVVKIQHELEFSEDAYIIDYSVNVPYLSEGPFYSLLARHFNVIPQNSVPVDNNIKQLPKWVKTLQLQDEDTINELLQRILSNAAVKNFVNKIPRHEEVVFCLGELPDELMNSLTEYMESTGDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FLW2</accession>
    <name>Q6FLW2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">AED2</name>
        <name evidence="2 3" type="ordered locus">CAGL0K13002g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448782.1">
        <property type="nucleotide sequence ID" value="XM_448782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FLW2"/>
    <dbReference type="STRING" id="284593.Q6FLW2"/>
    <dbReference type="GeneID" id="2890126"/>
    <dbReference type="KEGG" id="cgr:2890126"/>
    <dbReference type="CGD" id="CAL0133995">
        <property type="gene designation" value="AED2"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K13002g"/>
    <dbReference type="HOGENOM" id="CLU_312826_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FLW2"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="918"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG61745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="937" mass="104230" checksum="64E9A3204D2D8D50" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM03</accession>
    <name>Q6FM03_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0K12100g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM03"/>
    <dbReference type="FunCoup" id="Q6FM03">
        <property type="interactions" value="611"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FM03"/>
    <dbReference type="KEGG" id="cgr:2889969"/>
    <dbReference type="CGD" id="CAL0133797">
        <property type="gene designation" value="CAGL0K12100g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K12100g"/>
    <dbReference type="eggNOG" id="KOG1518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026169_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM03"/>
    <dbReference type="OMA" id="VHANWRY"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1500.10:FF:000006">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018375">
        <property type="entry name" value="Coprogen_oxidase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01021">
        <property type="entry name" value="COPROGEN_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0133797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="327" mass="37515" checksum="8EDC69D076AE58A7" modified="2004-07-19" version="1">MTAPQDPKHLPIRQQMEALIRRKQKEITEGLESIDTVKFTADTWERGNDGGGGTSMVIQNGSTFEKGGVNVSVVYGELTPGAVLAMKQEHKDLKLPESANGLPNSEGVKFFACGLSMVIHPVNPLAPTTHLNYRYFETWNPDGTPQTWWFGGGADLTPFYLFEEDAEHFHKLHKAALDKHDTALYPRFKKWCDEYFYIAHRGETRGIGGIFFDDYNEKDPQEILKICEDCFDAFLPSYLTIMKRRKDLPYNEKQKNWQLIRRGRYAEFNLIYDRGTQFGLRTPGSRVESILMSLPLHASWVYNHHPEPGSEEAKLLEVTTKPREWVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FM85</accession>
    <name>Q6FM85_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein PET100, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0K10120g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FM85"/>
    <dbReference type="FunCoup" id="Q6FM85">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2890109"/>
    <dbReference type="CGD" id="CAL0134557">
        <property type="gene designation" value="CAGL0K10120g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K10120g"/>
    <dbReference type="eggNOG" id="ENOG502S1QV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156745_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FM85"/>
    <dbReference type="OMA" id="MKLPFRY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0134557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12899" checksum="E51790214B6BB98A" modified="2004-07-19" version="1">MKLPFRYTRAQLEIFRFSFCLLAPVAVMYYIGTDTDKKLNVPGFWPDPESLNQIPKEPYEIKAELARMKKERLEKRLKLEKRLKEEFGLDVEAEKAKMREELGLTSKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="136" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMH6</accession>
    <name>Q6FMH6_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0K07986g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes. SRP54 interacts with the scR1 RNA and mediates the association of the resulting SRP-RNC complex with the signal recognition particle receptor (SR) via its alpha subunit SRP101. Both, SRP54 and SRP101, are locked in their GTP bound forms in the SRP-RNC-SR complex, which dissociates upon transferring the signal sequence to the protein-conducting channel (translocon). After signal sequence transfer, SRP54 and SRP101 act as reciprocal GTPase-activating proteins (GAPs), thereby resolving their association.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: srp72, srp68, srp54, sec65, srp21 and srp14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA and the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit srp101. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMH6"/>
    <dbReference type="FunCoup" id="Q6FMH6">
        <property type="interactions" value="1072"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMH6"/>
    <dbReference type="KEGG" id="cgr:2890370"/>
    <dbReference type="CGD" id="CAL0133963">
        <property type="gene designation" value="CAGL0K07986g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K07986g"/>
    <dbReference type="eggNOG" id="KOG0780">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_1_1"/>
    <dbReference type="InParanoid" id="Q6FMH6"/>
    <dbReference type="OMA" id="GMTGQDA"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0133963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG61531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="532" mass="58334" checksum="8C86F9ACE82C388B" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2005-04-26" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMM7</accession>
    <name>ATG12_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Autophagy-related protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">ATG12</name>
        <name type="ordered locus">CAGL0K06765g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ATG12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448517.1">
        <property type="nucleotide sequence ID" value="XM_448517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMM7"/>
    <dbReference type="SMR" id="Q6FMM7"/>
    <dbReference type="FunCoup" id="Q6FMM7">
        <property type="interactions" value="184"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMM7"/>
    <dbReference type="EnsemblFungi" id="CAGL0K06765g-T">
        <property type="protein sequence ID" value="CAGL0K06765g-T-p1"/>
        <property type="gene ID" value="CAGL0K06765g"/>
    </dbReference>
    <dbReference type="GeneID" id="2890405"/>
    <dbReference type="KEGG" id="cgr:2890405"/>
    <dbReference type="CGD" id="CAL0134023">
        <property type="gene designation" value="CAGL0K06765g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06765g"/>
    <dbReference type="eggNOG" id="KOG3439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106795_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMM7"/>
    <dbReference type="OMA" id="NIGELWM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031386">
        <property type="term" value="F:protein tag activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032258">
        <property type="term" value="P:cytoplasm to vacuole targeting by the Cvt pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0072">Autophagy</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="chain" id="PRO_0000212476" description="Ubiquitin-like protein ATG12">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Gly-Lys) (interchain with K-144 in ATG5)" evidence="1">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="181" mass="20017" checksum="8767518ABBA26397" modified="2004-07-19" version="1">MSRLLESEQESESGSENLVSSGSIALSKHEEQKRELGVENRLEQYSRRLSQLALVDTNESSDSSEKEEVFVQGSLRSQQSLKASIQSSSHGHTGAPQKVMIKFQSIGSITSITPSVCQISTNKPFSVIISFLQRKLKMENIHCYINNSFAPVPSQNVGDLWNQFKVNDELIVSYCGSVAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMP3</accession>
    <name>Q6FMP3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0K06391g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMP3"/>
    <dbReference type="FunCoup" id="Q6FMP3">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMP3"/>
    <dbReference type="KEGG" id="cgr:2890433"/>
    <dbReference type="CGD" id="CAL0134075">
        <property type="gene designation" value="CAGL0K06391g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K06391g"/>
    <dbReference type="eggNOG" id="KOG4778">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126124_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMP3"/>
    <dbReference type="OMA" id="DYAYKAP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3440:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019192">
        <property type="entry name" value="Ribosomal_mL40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09812">
        <property type="entry name" value="MRP-L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0134075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG61462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="146" mass="16919" checksum="8E8638993FE92FAB" modified="2004-07-19" version="1">MLRNTVGKSKTSIEQLMAKSQIVRYKRTKSQGGLSPLTQRVVTQLSVLSAARKQPKLLKLSKEDLVKHQTIERSWKLYQQQKTTRQLAQLKQQYLAMEEAMETLKSVSPELYEEANISEEGKQFPLDIKITTDAPPNKIWHYNFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMR1</accession>
    <name>Q6FMR1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">sphingosine kinase</fullName>
            <ecNumber evidence="10">2.7.1.91</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15 16" type="ordered locus">CAGL0K05995g</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(4R)-hydroxysphinganine + ATP = (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:64124"/>
            <dbReference type="ChEBI" id="CHEBI:64795"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.91"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33564"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51496"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:76941"/>
            <dbReference type="ChEBI" id="CHEBI:84410"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.91"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>sphinganine + ATP = sphinganine 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:57939"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.91"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15466"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.1.91" evidence="10"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMR1"/>
    <dbReference type="FunCoup" id="Q6FMR1">
        <property type="interactions" value="600"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMR1"/>
    <dbReference type="KEGG" id="cgr:2890448"/>
    <dbReference type="CGD" id="CAL0134535">
        <property type="gene designation" value="CAGL0K05995g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05995g"/>
    <dbReference type="eggNOG" id="KOG1116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013399_0_2_1"/>
    <dbReference type="InParanoid" id="Q6FMR1"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008481">
        <property type="term" value="F:sphingosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000005">
        <property type="entry name" value="Sphingosine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="14">
        <location>
            <begin position="398"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="214"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="CGD" id="CAL0134535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="CAG61444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="794" mass="88323" checksum="4E6893AA644AAD59" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMT9</accession>
    <name>Q6FMT9_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lethal giant larvae (Lgl)-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SRO7</name>
        <name evidence="3 4" type="ordered locus">CAGL0K05291g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448455.1">
        <property type="nucleotide sequence ID" value="XM_448455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMT9"/>
    <dbReference type="FunCoup" id="Q6FMT9">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FMT9"/>
    <dbReference type="GeneID" id="2890479"/>
    <dbReference type="KEGG" id="cgr:2890479"/>
    <dbReference type="CGD" id="CAL0133805">
        <property type="gene designation" value="SRO7"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K05291g"/>
    <dbReference type="eggNOG" id="KOG1983">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006030_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FMT9"/>
    <dbReference type="OMA" id="QIYVFGQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="2">
        <location>
            <begin position="549"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1048" mass="117240" checksum="21910AA95BB4F666" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FMW4</accession>
    <name>Q6FMW4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="ordered locus">CAGL0K04697g</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448430.1">
        <property type="nucleotide sequence ID" value="XM_448430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FMW4"/>
    <dbReference type="STRING" id="284593.Q6FMW4"/>
    <dbReference type="KEGG" id="cgr:2890009"/>
    <dbReference type="CGD" id="CAL0134631">
        <property type="gene designation" value="CAGL0K04697g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K04697g"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035625_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FMW4"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408:SF58">
        <property type="entry name" value="TRANSCRIPTION FACTOR (TFIIIA), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24408">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="CGD" id="CAL0134631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="CAG61391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="515" mass="57922" checksum="4CFF01AB6CCDB9A6" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN19</accession>
    <name>Q6FN19_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0K03465g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN19"/>
    <dbReference type="FunCoup" id="Q6FN19">
        <property type="interactions" value="660"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN19"/>
    <dbReference type="KEGG" id="cgr:2890176"/>
    <dbReference type="CGD" id="CAL0134243">
        <property type="gene designation" value="CAGL0K03465g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K03465g"/>
    <dbReference type="eggNOG" id="KOG4166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FN19"/>
    <dbReference type="OMA" id="QETDMIG"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901705">
        <property type="term" value="P:L-isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="83"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="279"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="486"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0134243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG61336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="677" mass="73346" checksum="E42A36B6EAFA2998" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN43</accession>
    <name>Q6FN43_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial carrier protein LEU5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">CAGL0K02915g</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN43"/>
    <dbReference type="FunCoup" id="Q6FN43">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN43"/>
    <dbReference type="KEGG" id="cgr:2890277"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_10_0_1"/>
    <dbReference type="InParanoid" id="Q6FN43"/>
    <dbReference type="OMA" id="VYERMKW"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000151">
        <property type="entry name" value="LEU5p Mitochondrial carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002167">
        <property type="entry name" value="GDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00928">
        <property type="entry name" value="GRAVESDC"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="115"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="247"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="CAG61312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38944" checksum="EB980A919CC37647" modified="2004-07-19" version="1">MTKTNNRQAVDKNSLDYVVRSGLAGGVSGSCAKTLIAPLDRIKILFQTSNPHYSKYAGSLVGLYEAAKHIWINDGIRGFFQGHSVTLLRIFPYAAVKFVAYEQIRSILIPSREYESHWRRLASGSLAGLCSVFITYPLDLTRVRLAYVTEHKRVKLRDIVKTIYHEPASEGLTSHLLVPKWFAHWCNFYRGYVPTVLGMIPYAGVSFFAHDLIHDIMKSSLMAPYAVKQLSSQEELERKKLRQKTPLRTWAELVAGGLSGILSQTAAYPLEIIRRRLQVSTLSPRKMYDHKFQSISSIARIIYQEKGWRGFFVGLSIGYIKVTPMVACSFFVYERMKWHLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN52</accession>
    <name>Q6FN52_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0K02695g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN52"/>
    <dbReference type="STRING" id="284593.Q6FN52"/>
    <dbReference type="KEGG" id="cgr:2890269"/>
    <dbReference type="CGD" id="CAL0134769">
        <property type="gene designation" value="CAGL0K02695g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02695g"/>
    <dbReference type="eggNOG" id="ENOG502S9M3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1627036_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FN52"/>
    <dbReference type="OMA" id="FRIKRKH"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0134769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG61303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="155" mass="18365" checksum="76C0C83FA3055E89" modified="2004-07-19" version="1">MVLEVVRNLLDEDINCASRRKSLIIVLGYDARSKLESLKNYKDEPLTVNSILRSRRDVHVLFLNSLQYIFMYLIKLEVQPDSHTHLVIYGLDSLINEMCQEDSLDLNQVRAANLIFQTAYRVSRQNQLQEVLFIAYDQKKWDKLEPLRKYWQEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN58</accession>
    <name>Q6FN58_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 14" type="ordered locus">CAGL0K02541g</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN58"/>
    <dbReference type="FunCoup" id="Q6FN58">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FN58"/>
    <dbReference type="KEGG" id="cgr:2890262"/>
    <dbReference type="CGD" id="CAL0134247">
        <property type="gene designation" value="CAGL0K02541g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K02541g"/>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FN58"/>
    <dbReference type="OMA" id="MANNSIK"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008361">
        <property type="term" value="P:regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002320">
        <property type="entry name" value="PRK01259.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF48">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="12">
        <location>
            <begin position="6"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="CGD" id="CAL0134247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="CAG61297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="321" mass="35162" checksum="267B293EFE2E5E1D" modified="2004-07-19" version="1">MPTNSIKLLAPDVHRGLAKLVAKRLGIELTDCKLKRDPSNEVSFSIGESVRDQDIFIITQIGSGTVNDRVLELLIMINASKTASARRITAIIPNFPYARQDRKDKSRAPITAKLMADMLTTAGCDHVITMDLHASQIQGFFDIPVDNLYAEPSVVRYIKENVKYEDAIIISPDAGGAKRAATLADRLDLNFALIHKERARANEVSRMVLVGDVTDKICIIVDDMADTCGTLAKAAEVLLDNGHAKSVIAIVTHGVLSGNAIANINNSRLDRVVCTNTVPFEDKMPQCPKLDVIDISSVLAEAIRRLHNGESISYLFKNYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FN92</accession>
    <name>Q6FN92_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Choline/carnitine acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0K01771g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380957">
        <property type="protein sequence ID" value="CAG61263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448302.1">
        <property type="nucleotide sequence ID" value="XM_448302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FN92"/>
    <dbReference type="STRING" id="284593.Q6FN92"/>
    <dbReference type="KEGG" id="cgr:2890028"/>
    <dbReference type="CGD" id="CAL0134359">
        <property type="gene designation" value="CAGL0K01771g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0K01771g"/>
    <dbReference type="eggNOG" id="KOG3719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013513_4_0_1"/>
    <dbReference type="InParanoid" id="Q6FN92"/>
    <dbReference type="OMA" id="NRWWDKS"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome K"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0134359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG61263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="662" mass="76711" checksum="100336AD0A95E30E" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNI3</accession>
    <name>Q6FNI3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="ordered locus">CAGL0J11462g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448211.1">
        <property type="nucleotide sequence ID" value="XM_448211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNI3"/>
    <dbReference type="STRING" id="284593.Q6FNI3"/>
    <dbReference type="KEGG" id="cgr:2889527"/>
    <dbReference type="CGD" id="CAL0133146">
        <property type="gene designation" value="CAGL0J11462g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J11462g"/>
    <dbReference type="eggNOG" id="ENOG502RZ9P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098355_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNI3"/>
    <dbReference type="OMA" id="WGRFDHT"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042631">
        <property type="term" value="P:cellular response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273459" description="Hydrophilin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="CGD" id="CAL0133146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG61162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22988" checksum="2FD913B77607560C" modified="2004-07-19" version="1">MKFSAVTVAAMAISSVLAKDRQYTTEITYTSDGATKTYTSTHKTHKYGKFNNTHHEGSKKPKSTGTHKYGKFNNTHHEGSKKPKSTGTHKYGKFNNTHHEGSKKPKSTGTHKYGKFNNTHHEGSKKPKSTGTHKYGKFNNTHHEGSKKPKSTGTHKYGKFNNTHHEKPTTEVEIKVPENDASGNRMNSMKLFGLTTGTAVVAGALMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNN8</accession>
    <name>Q6FNN8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 8">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="1 8">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="ordered locus">CAGL0J10230g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="1 8"/>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNN8"/>
    <dbReference type="FunCoup" id="Q6FNN8">
        <property type="interactions" value="107"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNN8"/>
    <dbReference type="KEGG" id="cgr:2889415"/>
    <dbReference type="CGD" id="CAL0133138">
        <property type="gene designation" value="CAGL0J10230g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10230g"/>
    <dbReference type="eggNOG" id="KOG1885">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_1"/>
    <dbReference type="InParanoid" id="Q6FNN8"/>
    <dbReference type="OMA" id="MKWGMPP"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="202"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0133138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="543" mass="61921" checksum="DCAF49AB08635B17" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-31" modified="2025-06-18" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNP6</accession>
    <name>YNF8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Vacuolar membrane protein CAGL0J10076g</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">CAGL0J10076g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PRM5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448148.1">
        <property type="nucleotide sequence ID" value="XM_448148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNP6"/>
    <dbReference type="FunCoup" id="Q6FNP6">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0J10076g-T">
        <property type="protein sequence ID" value="CAGL0J10076g-T-p1"/>
        <property type="gene ID" value="CAGL0J10076g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889408"/>
    <dbReference type="CGD" id="CAL0133738">
        <property type="gene designation" value="CAGL0J10076g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J10076g"/>
    <dbReference type="eggNOG" id="ENOG502S625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061224_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FNP6"/>
    <dbReference type="OMA" id="MEGYHKR"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0926">Vacuole</keyword>
    <feature type="chain" id="PRO_0000409316" description="Vacuolar membrane protein CAGL0J10076g">
        <location>
            <begin position="1"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="378" mass="41953" checksum="F9735320FFE2A383" modified="2004-07-19" version="1">MLRRKRAFTDESLMLMERGLPRLVTTSTTPTPTTEPTTEPTTTKDETSQTSATDASTATTSTAATSTAATSSTSTDITATSLTITSSSLSTDVANIVPPSAENNPYIFRTSALSGTVFIAVGSIAGAILMLIFLWWSITKYLNYKRTKKDYLESMATQYPYGSRGGHAHHSSIFSTASSDVYSYGGDDEKLSLGHSRSQSVDKKTHEKVKKSKIGLFGGSTNDIFKTPTRNDSWESLSDAITNYGDGSVHRFNPIQDDIQYNNRRSLFISPTVEVMNLPRQEVPDIFATPKKQQTSIYNDYDTPLIPDLSKPEDVALSPQRSHRKTPSNDKYHRRNRSSANLSPSRSPTRTPIRTRNMARDHRKTPSMYLEDLLDDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FNQ1</accession>
    <name>Q6FNQ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial protein import protein MAS5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">YDJ1</name>
        <name evidence="10 11" type="ordered locus">CAGL0J09966g</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG61094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_448143.1">
        <property type="nucleotide sequence ID" value="XM_448143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FNQ1"/>
    <dbReference type="FunCoup" id="Q6FNQ1">
        <property type="interactions" value="1372"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FNQ1"/>
    <dbReference type="GeneID" id="2889428"/>
    <dbReference type="KEGG" id="cgr:2889428"/>
    <dbReference type="CGD" id="CAL0133394">
        <property type="gene designation" value="YDJ1"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J09966g"/>
    <dbReference type="eggNOG" id="KOG0712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_10_0_1"/>
    <dbReference type="InParanoid" id="Q6FNQ1"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140602">
        <property type="term" value="C:nucleolar peripheral inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140453">
        <property type="term" value="C:protein aggregate center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140455">
        <property type="term" value="P:cytoplasm protein quality control"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140454">
        <property type="term" value="P:protein aggregate center assembly"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035719">
        <property type="term" value="P:tRNA import into nucleus"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000036">
        <property type="entry name" value="Type I HSP40 co-chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="128"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="CGD" id="CAL0133394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="CAG61094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44375" checksum="A5AFCEF7BCBF2011" modified="2004-07-19" version="1">MVKDTKLYDTLGVSPGASDAEIKKAYRKSALKYHPDKNPSEEAAEKFKEVSSAYEILSDSQKREVYDQFGEEGLSGNGGAGFPGGFGFGEDIFSQFFGGATGGRPRGPQRGRDIKHEMAASLEELYKGRTAKLALNKQILCKSCEGRGGKEGAVKKCSSCNGQGIKFVTRQMGPMIQRFQTECDVCHGTGDIIDAKDRCKSCNGKKVDNERKILEVRIEPGMKDGQKIVFKGEADQAPDVIPGDVVFVISEKPHKHFQRAGDDLIYEAEIDLLTALAGGQFALEHVSGDWLKVDIVPGEVIAPGARKIVEGKGMPIQKYGGYGNLLIKFNIKFPENHFTSEENLKKLEEILPPRRQINIPAKAQVDDCVLSEFDPSKFGQSNGRSGANYDSDDEDAHGGEGVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP65</accession>
    <name>Q6FP65_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0J06270g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP65"/>
    <dbReference type="FunCoup" id="Q6FP65">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP65"/>
    <dbReference type="KEGG" id="cgr:2889583"/>
    <dbReference type="CGD" id="CAL0133136">
        <property type="gene designation" value="CAGL0J06270g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J06270g"/>
    <dbReference type="eggNOG" id="ENOG502QR5V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025347_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP65"/>
    <dbReference type="OMA" id="YIDEPLM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="CGD" id="CAL0133136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG60930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="725" mass="83232" checksum="E7A913591690A455" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP81</accession>
    <name>Q6FP81_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein NSG2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="ordered locus">CAGL0J05918g</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP81"/>
    <dbReference type="FunCoup" id="Q6FP81">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP81"/>
    <dbReference type="KEGG" id="cgr:2889772"/>
    <dbReference type="CGD" id="CAL0133746">
        <property type="gene designation" value="CAGL0J05918g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05918g"/>
    <dbReference type="eggNOG" id="ENOG502QX4Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088332_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FP81"/>
    <dbReference type="OMA" id="PMISECL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="CGD" id="CAL0133746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="CAG60914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36166" checksum="E4358560D7A5BC2A" modified="2004-07-19" version="1">MVKGRKKKAVKTVESSESISSLTTPQLYSIYDQDIVKSEDAEIYEELKRSRSKSSSLDTPLYAIDEIIHLKKDNDKVNESPLIDVSEGSHIRPLSQHKKLINETLLTPSMSAGGNLGLDATMANTMSFHVTPFQRFTNFVFAIVVLSISGVAYHQLSRNLHDNHLLHEDFASRPLLWGVTIQQKLSCGILPDWFGYALEGIIFGSIIPLMDHITKVKLRPTSYSLSSVIRSINAMLGVTFGIRKIQWASSGQAAGAWGLLNVILWLFFDGTLSMFSNCSVLGLLCCASCFHEITDVSQFLYFMDFYFLGSLMFGKIGRYLYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FP99</accession>
    <name>Q6FP99_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 17" type="ordered locus">CAGL0J05522g</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FP99"/>
    <dbReference type="FunCoup" id="Q6FP99">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FP99"/>
    <dbReference type="KEGG" id="cgr:2889484"/>
    <dbReference type="CGD" id="CAL0133740">
        <property type="gene designation" value="CAGL0J05522g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J05522g"/>
    <dbReference type="eggNOG" id="KOG0036">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015166_2_2_1"/>
    <dbReference type="InParanoid" id="Q6FP99"/>
    <dbReference type="OMA" id="SGQWWKQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="198"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="318"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="425"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="CGD" id="CAL0133740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="CAG60896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="519" mass="58492" checksum="90133B881B4A5E65" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-05-03" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPF1</accession>
    <name>VPS10_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Carboxypeptidase Y receptor</fullName>
            <shortName>CPY receptor</shortName>
        </alternativeName>
        <alternativeName>
            <fullName>Sortilin VPS10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Vacuolar carboxypeptidase sorting receptor VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">VPS10</name>
        <name type="ordered locus">CAGL0J04312g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="1">Cycles between the Golgi apparatus and the prevacuolar compartment.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the VPS10-related sortilin family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPF1"/>
    <dbReference type="SMR" id="Q6FPF1"/>
    <dbReference type="FunCoup" id="Q6FPF1">
        <property type="interactions" value="248"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPF1"/>
    <dbReference type="GlyCosmos" id="Q6FPF1">
        <property type="glycosylation" value="6 sites, No reported glycans"/>
    </dbReference>
    <dbReference type="EnsemblFungi" id="CAGL0J04312g-T">
        <property type="protein sequence ID" value="CAGL0J04312g-T-p1"/>
        <property type="gene ID" value="CAGL0J04312g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889655"/>
    <dbReference type="CGD" id="CAL0133276">
        <property type="gene designation" value="CAGL0J04312g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J04312g"/>
    <dbReference type="eggNOG" id="KOG3511">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000700_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPF1"/>
    <dbReference type="OMA" id="ECDYNYY"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000998">
        <property type="entry name" value="VPS10 homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52072">
        <property type="entry name" value="VPS10P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-0675">Receptor</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000407511" description="Vacuolar protein sorting/targeting protein 10">
        <location>
            <begin position="20"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1352"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="2">
        <location>
            <begin position="1373"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="domain" description="Vps10p 1" evidence="3">
        <location>
            <begin position="21"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 2">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 3">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 4">
        <location>
            <begin position="423"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 5">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Vps10p 2" evidence="3">
        <location>
            <begin position="681"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 6">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 7">
        <location>
            <begin position="814"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 8">
        <location>
            <begin position="1099"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="repeat" description="BNR 9">
        <location>
            <begin position="1141"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-bladed beta-propeller 1" evidence="3">
        <location>
            <begin position="21"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="10CCa cysteine-knot 1" evidence="3">
        <location>
            <begin position="540"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="10CCb cysteine-knot 1" evidence="3">
        <location>
            <begin position="591"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="651"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-bladed beta-propeller 2" evidence="3">
        <location>
            <begin position="681"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="10CCa cysteine-knot 2" evidence="3">
        <location>
            <begin position="1204"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="10CCb cysteine-knot 2" evidence="3">
        <location>
            <begin position="1263"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1480"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1480"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1505"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="746"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="966"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="1260"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="383"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="540"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="555"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="591"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="598"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="623"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1046"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1204"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1228"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1263"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1270"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="1297"/>
            <end position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="1514" mass="170452" checksum="8A684BBF502DC919" modified="2004-07-19" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPG6</accession>
    <name>Q6FPG6_CANGA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0J03982g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447878.1">
        <property type="nucleotide sequence ID" value="XM_447878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPG6"/>
    <dbReference type="KEGG" id="cgr:2889665"/>
    <dbReference type="CGD" id="CAL0133040">
        <property type="gene designation" value="CAGL0J03982g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03982g"/>
    <dbReference type="HOGENOM" id="CLU_2108717_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPG6"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0133040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="115" mass="13160" checksum="0B6894FCDE0B9F6B" modified="2004-07-19" version="1">MFYAAYRANISQPGPVQWNKYCRKWYKNGVWSLMVVVNSWTDRNTSTFEGYSIQRLPEGIIAGYSSLEEGVGTSRAIVYEPHIQYSYKQLVGTISNSIYPPKFGITCLSFDTRLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-06-28" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPK1</accession>
    <name>TDA2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Topoisomerase I damage affected protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">TDA2</name>
        <name type="ordered locus">CAGL0J03190g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <text evidence="1">Concentrates at cytoplasmic punctate structures and localizes at the mating projection tip.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447843.1">
        <property type="nucleotide sequence ID" value="XM_447843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPK1"/>
    <dbReference type="SMR" id="Q6FPK1"/>
    <dbReference type="FunCoup" id="Q6FPK1">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPK1"/>
    <dbReference type="EnsemblFungi" id="CAGL0J03190g-T">
        <property type="protein sequence ID" value="CAGL0J03190g-T-p1"/>
        <property type="gene ID" value="CAGL0J03190g"/>
    </dbReference>
    <dbReference type="GeneID" id="2889730"/>
    <dbReference type="KEGG" id="cgr:2889730"/>
    <dbReference type="CGD" id="CAL0133432">
        <property type="gene designation" value="CAGL0J03190g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J03190g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03190g"/>
    <dbReference type="eggNOG" id="ENOG502S7YH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137494_1_0_1"/>
    <dbReference type="InParanoid" id="Q6FPK1"/>
    <dbReference type="OMA" id="TIIWISK"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110131">
        <property type="term" value="C:Aim21-Tda2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000813">
        <property type="term" value="P:negative regulation of barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd21457">
        <property type="entry name" value="DLC-like_TDA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0966">Cell projection</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000410729" description="Topoisomerase I damage affected protein 2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P40045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="112" mass="12416" checksum="F5A67D898326D97B" modified="2004-07-19" version="1">MVIEKIDDKSSNSPLTAPRLIDLIESQFSESQVSADTLIQHILESLNKHSSQYKYIVSVTSIDIPTESSSSCEIDNKFGASWNAKKDGFLTHVLEDKHAGKNHVVSVAWLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="139" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPK5</accession>
    <name>Q6FPK5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">General negative regulator of transcription subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0J03102g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CR380956">
        <property type="protein sequence ID" value="CAG60788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPK5"/>
    <dbReference type="FunCoup" id="Q6FPK5">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FPK5"/>
    <dbReference type="KEGG" id="cgr:2889726"/>
    <dbReference type="CGD" id="CAL0133292">
        <property type="gene designation" value="CAGL0J03102g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J03102g"/>
    <dbReference type="eggNOG" id="KOG2068">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028046_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPK5"/>
    <dbReference type="OMA" id="DGTYMDG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000257">
        <property type="entry name" value="CCR4-NOT core complex subunit Not4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000006">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
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        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
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        <property type="entry name" value="zf-RING_4"/>
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        <property type="entry name" value="RING/U-box"/>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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        <property type="entry name" value="ZF_C3H1"/>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="137"/>
            <end position="231"/>
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    <feature type="domain" description="C3H1-type" evidence="16">
        <location>
            <begin position="228"/>
            <end position="255"/>
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    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="228"/>
            <end position="255"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="102"/>
            <end position="124"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
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    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="352"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
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            <begin position="270"/>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
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        <source>
            <dbReference type="CGD" id="CAL0133292"/>
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        <source>
            <dbReference type="EMBL" id="CAG60788.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
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    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="620" mass="68240" checksum="0A1F567926A67018" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2004-10-11" modified="2025-04-09" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPW3</accession>
    <name>G3P1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName>Glyceraldehyde-3-phosphate dehydrogenase 1</fullName>
            <shortName>GAPDH 1</shortName>
            <ecNumber>1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">GPD1</name>
        <name type="ordered locus">CAGL0J00451g</name>
    </gene>
    <organism>
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12"/>
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        <property type="protein sequence ID" value="CAG60678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_447731.1">
        <property type="nucleotide sequence ID" value="XM_447731.1"/>
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    <dbReference type="STRING" id="284593.Q6FPW3"/>
    <dbReference type="EnsemblFungi" id="CAGL0J00451g-T">
        <property type="protein sequence ID" value="CAGL0J00451g-T-p1"/>
        <property type="gene ID" value="CAGL0J00451g"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889895"/>
    <dbReference type="CGD" id="CAL0133056">
        <property type="gene designation" value="CAGL0J00451g"/>
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    <dbReference type="VEuPathDB" id="FungiDB:B1J91_J00451g"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0J00451g"/>
    <dbReference type="eggNOG" id="KOG0657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_3_1"/>
    <dbReference type="InParanoid" id="Q6FPW3"/>
    <dbReference type="OMA" id="TCQMIRL"/>
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        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome J"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
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    <dbReference type="GO" id="GO:0062040">
        <property type="term" value="C:fungal biofilm matrix"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CGD"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000145542" description="Glyceraldehyde-3-phosphate dehydrogenase 1">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
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        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="3"/>
    <sequence length="332" mass="35919" checksum="E301E384BDDBDAB0" modified="2004-07-19" version="1">MVRVAINGFGRIGRIVLRIAMKRDGIDVVAINDPFITNDYAAYMFKYDSTHGRYDGEVTHDDKDLIIDGKAIKCYQERDPADLPWGDNDIDIVIEATGVFTAKDLAEKHITAGAKKVVITGPSATAPMFVKGVNDDKYTSDVTVISNASCTTNCLAPLAKVLQDNFGIEEALMSTVHSQTATQKTVDGPSKKDWRGGRTASANIIPSSTGAAKAVTKVLPELEGKLTGMAFRVPTVDVSVVDLTVRFAKDVTYDEIKAAIKKASEGEMKGILAYTEDAVVSTDFLGDTHSSIFDASAGIQLSPRFVKLVSWYDNEYGFSARVVDMVELVSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FPY4</accession>
    <name>Q6FPY4_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme suppressor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="ordered locus">CAGL0I10813g</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FPY4"/>
    <dbReference type="FunCoup" id="Q6FPY4">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2889349"/>
    <dbReference type="CGD" id="CAL0132662">
        <property type="gene designation" value="CAGL0I10813g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I10813g"/>
    <dbReference type="eggNOG" id="ENOG502S1UD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085772_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FPY4"/>
    <dbReference type="OMA" id="RAWNRIM"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="CGD" id="CAL0132662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="CAG60655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27661" checksum="8DE50C622804A8AF" modified="2004-07-19" version="1">MRIATRRLLREWKHYNRTVRQDEALFYMKPHDSNMFVWHVVLRDFKQTGHELYILLYLHQPENDNSIIVMKCLTPNNKLPINRNVSLTHLQNLLLLEHGFVKLIDHIWGMFFRTTDTLMNNNTQINSRLCYSWNRIVCKDFVRVFPELCGLLQEGDYDLVRSYRHKLNAIQSQNSSNCSTTKPMDDSFYFGFNKGIPPSNGLTHNFLACDSRPSHKHGGEIIEEMQSSLKRRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ04</accession>
    <name>Q6FQ04_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">CAGL0I10362g</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60635.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ04"/>
    <dbReference type="KEGG" id="cgr:2889213"/>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I10362g"/>
    <dbReference type="eggNOG" id="ENOG502QPQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_238795_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQ04"/>
    <dbReference type="OMA" id="EVTHYEV"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1560">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049451">
        <property type="entry name" value="AWP2-like_YTTT_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018871">
        <property type="entry name" value="GLEYA_adhesin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10528">
        <property type="entry name" value="GLEYA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20646">
        <property type="entry name" value="Hpf1_C"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004273402" description="PA14 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="69"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="3">
        <location>
            <begin position="681"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1608"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1622"/>
            <end position="1640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="CAG60635.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1772" mass="190597" checksum="8CD39E67336F1CE3" modified="2008-09-23" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ52</accession>
    <name>Q6FQ52_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter ESBP6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0I09108g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447642.1">
        <property type="nucleotide sequence ID" value="XM_447642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQ52"/>
    <dbReference type="FunCoup" id="Q6FQ52">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888965"/>
    <dbReference type="CGD" id="CAL0132404">
        <property type="gene designation" value="CAGL0I09108g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I09108g"/>
    <dbReference type="eggNOG" id="KOG2504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_1_2_1"/>
    <dbReference type="InParanoid" id="Q6FQ52"/>
    <dbReference type="OMA" id="AVNVICI"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0132404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="631" mass="69697" checksum="818F1689ECA89A57" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQ77</accession>
    <name>Q6FQ77_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">37S ribosomal protein MRP2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0I08481g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q6FQ77">
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    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQ77"/>
    <dbReference type="KEGG" id="cgr:2888921"/>
    <dbReference type="CGD" id="CAL0132326">
        <property type="gene designation" value="CAGL0I08481g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I08481g"/>
    <dbReference type="eggNOG" id="KOG1741">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_2_1_1"/>
    <dbReference type="InParanoid" id="Q6FQ77"/>
    <dbReference type="OMA" id="FGLCRNQ"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00076896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0132326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="114" mass="13289" checksum="B96DD88F75F11386" modified="2004-07-19" version="1">MTFRFPVKTKLPPGFLNARVIRDNFKRQQFAEHEITAKALKYIARNTTLPPRARLEAQLQLSSMPNYTRLTQVKNRCIESGHARAVLSDFRLCRYQFRERALKGELPGVKKGVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQQ1</accession>
    <name>Q6FQQ1_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="ordered locus">CAGL0I04466g</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQQ1"/>
    <dbReference type="FunCoup" id="Q6FQQ1">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQQ1"/>
    <dbReference type="KEGG" id="cgr:2889052"/>
    <dbReference type="CGD" id="CAL0130388">
        <property type="gene designation" value="CAGL0I04466g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I04466g"/>
    <dbReference type="eggNOG" id="ENOG502R17J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024078_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FQQ1"/>
    <dbReference type="OMA" id="NCWKNEN"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990615">
        <property type="term" value="C:Kelch-containing formin regulatory complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030950">
        <property type="term" value="P:establishment or maintenance of actin cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905047">
        <property type="term" value="P:mitotic spindle pole body organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001100">
        <property type="term" value="P:negative regulation of exit from mitosis"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
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        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090337">
        <property type="term" value="P:regulation of formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060627">
        <property type="term" value="P:regulation of vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053039">
        <property type="entry name" value="Polarity_Bud-Selection_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47775:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="267"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="85"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="464"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="713"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="CGD" id="CAL0130388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="CAG60380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="762" mass="84803" checksum="E3BB5DFFB1263D09" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FQY5</accession>
    <name>Q6FQY5_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 7" type="ordered locus">CAGL0I02464g</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="CR380955">
        <property type="protein sequence ID" value="CAG60296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FQY5"/>
    <dbReference type="FunCoup" id="Q6FQY5">
        <property type="interactions" value="762"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FQY5"/>
    <dbReference type="KEGG" id="cgr:2889383"/>
    <dbReference type="CGD" id="CAL0132060">
        <property type="gene designation" value="CAGL0I02464g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0I02464g"/>
    <dbReference type="eggNOG" id="KOG2001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007738_2_0_1"/>
    <dbReference type="InParanoid" id="Q6FQY5"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome I"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008275">
        <property type="term" value="C:gamma-tubulin small complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005822">
        <property type="term" value="C:inner plaque of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005824">
        <property type="term" value="C:outer plaque of spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2 4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="5">
        <location>
            <begin position="68"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="CGD" id="CAL0132060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="CAG60296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="816" mass="95227" checksum="F43F55886E72CD73" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="138" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRR3</accession>
    <name>Q6FRR3_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SLN1</name>
        <name evidence="20 21" type="ordered locus">CAGL0H06567g</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG60014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_447081.1">
        <property type="nucleotide sequence ID" value="XM_447081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRR3"/>
    <dbReference type="FunCoup" id="Q6FRR3">
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        <property type="component" value="Chromosome H"/>
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        <location>
            <begin position="20"/>
            <end position="50"/>
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    <sequence length="1169" mass="130653" checksum="17FF75F5E34C6D46" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRT9</accession>
    <name>Q6FRT9_CANGA</name>
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        <recommendedName>
            <fullName evidence="1">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="ordered locus">CAGL0H05951g</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="CAG59988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene designation" value="CAGL0H05951g"/>
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    <dbReference type="eggNOG" id="KOG4690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome H"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
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        <property type="entry name" value="OXLD1"/>
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        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="1">
        <location>
            <begin position="70"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
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            <dbReference type="CGD" id="CAL0131796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="CAG59988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="228" mass="26236" checksum="583E554BAB4527D0" modified="2004-07-19" version="1">MMITMRATMRANMTMRRFSSCRKISMTFEGNTRGIAATPEERMQRIFGGRLKGEPPKSTSRILTGGSKLIAGVEVPEKPGQPDNCCMSGCVNCVWELYNDDVRYWKQKRNEAALKIRDSTEVWPSNWDPPLDKLEMKNLPPTLHGKKMKLEEDLAKQHQTVANLFPKRTNPLPKSVQQAKQRNLAKKIHTPVEENDGWDDIPVYIKAFAEFERQRKLKKNKIQPQTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FRX8</accession>
    <name>Q6FRX8_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rad50/SbcC-type AAA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14 15" type="ordered locus">CAGL0H05071g</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FRX8"/>
    <dbReference type="FunCoup" id="Q6FRX8">
        <property type="interactions" value="904"/>
    </dbReference>
    <dbReference type="STRING" id="284593.Q6FRX8"/>
    <dbReference type="KEGG" id="cgr:2888697"/>
    <dbReference type="CGD" id="CAL0131790">
        <property type="gene designation" value="CAGL0H05071g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H05071g"/>
    <dbReference type="eggNOG" id="KOG0250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009063_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FRX8"/>
    <dbReference type="OMA" id="FMCHRSL"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071139">
        <property type="term" value="P:resolution of DNA recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblFungi"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="13">
        <location>
            <begin position="82"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="270"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="372"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="815"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="898"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="CGD" id="CAL0131790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="CAG59949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="1110" mass="127663" checksum="32DD9AE0B6E7C627" modified="2004-07-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="134" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FS41</accession>
    <name>Q6FS41_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 18" type="ordered locus">CAGL0H03663g</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FS41"/>
    <dbReference type="STRING" id="284593.Q6FS41"/>
    <dbReference type="KEGG" id="cgr:2888820"/>
    <dbReference type="CGD" id="CAL0131960">
        <property type="gene designation" value="CAGL0H03663g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H03663g"/>
    <dbReference type="eggNOG" id="KOG1526">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_1"/>
    <dbReference type="InParanoid" id="Q6FS41"/>
    <dbReference type="OMA" id="HNTFRYG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF41">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="10"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="76"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="95"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="311"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="CGD" id="CAL0131960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="CAG59886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000002428"/>
        </source>
    </evidence>
    <sequence length="418" mass="47368" checksum="CC7A3D05F41824BE" modified="2004-07-19" version="1">MAGKIKVKNPIVEMDGDEMTRVIWGMVKDKLIYPYLDVDLKYYDLSIQHRDETEDRVTVDAAEATLKHGVAIKCATITPDEARMKEFHLKKMWKSPNGTIRNILGGTVFREPIIIPRIPRIVPTWNKPIIIGRHAFGDQYKASDAVIKEPGKLELVFTPASGQGNPKTIKVYDYKSPGVALAMYNTDESITGFARASFELAIKRKLPLFFTTKNTILKKYDGRFKDIFQKMYDEDYKGKFKELGISYEHRLIDDMVAQMIKSKGGFIIAMKNYDGDVQSDIVAQGFGSLGLMTSTLLTPDGKIFESEAAHGTVTRHYRQYQKGKETSTNSIATIFAWSQGIIHRGKVDQTPDVRLFGEILERSTIDTVQIDGIMTKDLALILGKTERKDYASTEEFIDAVARRLKREFNSHFNKPSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-19" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q6FSC2</accession>
    <name>Q6FSC2_CANGA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="ordered locus">CAGL0H01683g</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138)</name>
        <name type="common">Yeast</name>
        <name type="synonym">Nakaseomyces glabratus</name>
        <dbReference type="NCBI Taxonomy" id="284593"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Saccharomycotina</taxon>
            <taxon>Saccharomycetes</taxon>
            <taxon>Saccharomycetales</taxon>
            <taxon>Saccharomycetaceae</taxon>
            <taxon>Nakaseomyces</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Nature" volume="430" first="35" last="44">
            <title>Genome evolution in yeasts.</title>
            <authorList>
                <consortium name="Genolevures"/>
                <person name="Dujon B."/>
                <person name="Sherman D."/>
                <person name="Fischer G."/>
                <person name="Durrens P."/>
                <person name="Casaregola S."/>
                <person name="Lafontaine I."/>
                <person name="de Montigny J."/>
                <person name="Marck C."/>
                <person name="Neuveglise C."/>
                <person name="Talla E."/>
                <person name="Goffard N."/>
                <person name="Frangeul L."/>
                <person name="Aigle M."/>
                <person name="Anthouard V."/>
                <person name="Babour A."/>
                <person name="Barbe V."/>
                <person name="Barnay S."/>
                <person name="Blanchin S."/>
                <person name="Beckerich J.M."/>
                <person name="Beyne E."/>
                <person name="Bleykasten C."/>
                <person name="Boisrame A."/>
                <person name="Boyer J."/>
                <person name="Cattolico L."/>
                <person name="Confanioleri F."/>
                <person name="de Daruvar A."/>
                <person name="Despons L."/>
                <person name="Fabre E."/>
                <person name="Fairhead C."/>
                <person name="Ferry-Dumazet H."/>
                <person name="Groppi A."/>
                <person name="Hantraye F."/>
                <person name="Hennequin C."/>
                <person name="Jauniaux N."/>
                <person name="Joyet P."/>
                <person name="Kachouri R."/>
                <person name="Kerrest A."/>
                <person name="Koszul R."/>
                <person name="Lemaire M."/>
                <person name="Lesur I."/>
                <person name="Ma L."/>
                <person name="Muller H."/>
                <person name="Nicaud J.M."/>
                <person name="Nikolski M."/>
                <person name="Oztas S."/>
                <person name="Ozier-Kalogeropoulos O."/>
                <person name="Pellenz S."/>
                <person name="Potier S."/>
                <person name="Richard G.F."/>
                <person name="Straub M.L."/>
                <person name="Suleau A."/>
                <person name="Swennene D."/>
                <person name="Tekaia F."/>
                <person name="Wesolowski-Louvel M."/>
                <person name="Westhof E."/>
                <person name="Wirth B."/>
                <person name="Zeniou-Meyer M."/>
                <person name="Zivanovic I."/>
                <person name="Bolotin-Fukuhara M."/>
                <person name="Thierry A."/>
                <person name="Bouchier C."/>
                <person name="Caudron B."/>
                <person name="Scarpelli C."/>
                <person name="Gaillardin C."/>
                <person name="Weissenbach J."/>
                <person name="Wincker P."/>
                <person name="Souciet J.L."/>
            </authorList>
            <dbReference type="PubMed" id="15229592"/>
            <dbReference type="DOI" id="10.1038/nature02579"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS 138</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CR380954">
        <property type="protein sequence ID" value="CAG59805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q6FSC2"/>
    <dbReference type="FunCoup" id="Q6FSC2">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="KEGG" id="cgr:2888869"/>
    <dbReference type="CGD" id="CAL0130468">
        <property type="gene designation" value="CAGL0H01683g"/>
    </dbReference>
    <dbReference type="VEuPathDB" id="FungiDB:CAGL0H01683g"/>
    <dbReference type="eggNOG" id="ENOG502QU5T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020222_0_0_1"/>
    <dbReference type="InParanoid" id="Q6FSC2"/>
    <dbReference type="OMA" id="HFWIIPG"/>
    <dbReference type="Proteomes" id="UP000002428">
        <property type="component" value="Chromosome H"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF9">
        <property type="entry name" value="URACIL CATABOLISM PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="51"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="617"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="CGD" id="CAL0130468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="CAG59805.1"/>
        </source>
